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TL 3M General Offices Su oon rad mpgs genq- 0704- 15607 3M Certified Mail AL - 80S July 6, 2004 Document Processing Center OEUfPSfAitceEraoasftP-olRlouodomn6P4r2e8veAntttin:onSaencdtiToonx8i(cs) W1a2s0h0iPnegninosnylDvCani2a04A6v0e-n0u0e01NW RE: TprSoCtAci8v5e)maSteUrBiaSlTANTIAL RISK NOTICE ON: Dear Sirs: ItnauchreJdu,neM28,d2s0c0u4s,esdubsmoimsesisounpgplaermdeintnagltihnefosrmuatbion.testEnsucblsotsaendcepl(epsleesnedsee CD containing the supplemental report "Augmented acute (4-hour) inhalation toxicity study with T-7875 in rats." The enclosed study report does not contain confidential information. Sincerely, (Ae eal CRheegruilaKteodrryoSwpsekciialist ---- CONTA , wo C8 TI en LTT s So - IM Gener Offices I1StM.7FCae,mMtsiNn53148-1000 3M Certified Mail DEoPcAumEeasntt~PRroocoesmsi6n4g28CeAntttenr: Section 8c) OUfSfiEcPeoAfPollution Prevention and Toxics W1a2s0h0iPnegninosnylDvCani2a04A6v0e-n0u0e01NW RE: TprSotCeActi8v(eE)maSteUrBiaSlTANTIAL RISK NOTICE ON: SANITIZED Dear Sirs: ca3toMtnadchuhacesdt.erdecweiitvhedapprreoltiemcitinvaerymarteesruilatls. foTrhaefcooumr-phoosuirtiaocnutfeorinthhaislatteisotnssutbusdtyanicnerafsts eATinhgiehmtsatfluesdmyawleweraersastcscohnwededurucelteeedxdptobobsyeeTdoNtbOosetNrhuevtetrdeisttfioosrnufbaosnutrdatneFceoenovddaapyRoser.seaatr5c.h4. mEgi/gLhtfomralfeouarnhdours. meSxohpodorestrularyteea,ftsaellrlugeagxnipisomhsanulerssews,,earplielaooenbrisemecatrlivsoends,hatoonwdheadbvleselplihagahbrtoorbserpdeaasbtmrh.eiantghWiiantbghroiarnnmdoalnbieotdidcyasy,weosilfgighhtt loorss. Within four daysof exposure, two male and two female rats had did. EWTuhhrieocpthee.sftomrTamrtsaeirlniaeardlgeoisp(ea4rn0a-ti2on0rd0ussmtairpicparlloyn(stn)hoe,np-nrocono-dnrusecustmpeiurrs)aibnplgrelododrwuo-cpptlrecetossmscmureoermcpsiaparrlaelydye1aq0vuatiihplemaebnlet,in eparxeorpodosusocultriezwehadsespnearsutssimecedlneasts(wd1hi-ir2cechmtieicdnr.doincsa)teussmeidniinmathle-tsou-bnjeocrtesstpuirdayb.le3eMxphoassurceontdoutchtiesd an ; psTruwebvsoitocauansrclleyiwrcisottnhuddluilcetsceoadmreapnornealecenuvttaesntientxhocaeElpaPttAit'ohnse saatncuatdliyyvseoiisnnogarfsetodhlieevsneetn)treacstounl5tt.rs5.olmgF(i/trLsh.te, te3IsMnt thhiasd setxupdoys,urtew,obmualteheasnedeftfweoctfsewmearlee rnaotslsonhgoewreodbssleirgvhetdbrsehoartthliyngafatbenroerxmpaolsituirees during (Sceocnotnadi,ni3ngM1h.a2d%parcetviivoeusilngyrceodniednutc)teatd2a0n.7acmugt/eL.inhOalnaetoiofntshteudeiygohtn aanriemlaaltsedepxrpoodsuecdt "DocOPufafmgieceenoftPoPlrloucieossninPgreCveennttieorn and Tosics : 62872004 s(ncefchorueordopusflyee.dacfShoeuvsreetxne)e,onfs-dctahhyeedroubelsmeeadrivnfaoitrnigsoanecirpgiehfrtiicoaedn,iimmamanelddsit(hafetoeuflriynoaflafaatnecrihmeaxslpeoxws)aursdeis,eaddcridieufdriicbneegsfodtrhueee to ectoxsupmlodosrunrioebtuadnsedftihcneointfdioivrtemiluoynlb.aetTiahotintsrwisbatusutdendyevhtoeardthcneoomatcmbteierveceniairlneigprzoeerddti,eednatne,adrWltiheeer rhbeaesvcuelatuissneocfltuhtdeheredesiwttua2dssy no (sdu-phpoluerm)enitnhaallaitnifoonrmtaotxiicointyinstthuidsyswuibtmhitTta-l7.8E7ncinlorsaetd."please find "Augmented acute A final report will be forwarded to EPA when received, 5On5un1mc4be4,eardpoocsktealt cnaurmdbteorChhaesribeKeendraoswssikgin,ed3fMorCtehnistesrubBmlidtgt.al2,2p0l-e2aEs.e0s2e,nSdt.thPeaudlo,ckMeNt qPuleesatsieocnosnotraicftwReogcearnPperrkoivnisd,e Pahd.dDi.tioDnaAlBiTnfo(r6m5a1t-i7o3n3.-3222) if you have any CTohnefisdpeenctiifailcicthyecmliaciaml: identityof `confidential business information ounnetilinagrpeadtieennttaopfpltihceattiesotn siusbfslteadnce is held to be Sincerely, Larry StaffVice RZobel, MD President MPH and Medical Dircetor OPDfoafcgiuecmoenftPoPlrlocieosnsiPngeCveennteorn and Toxics aad Protective Material Test Substance Composition Aromas) [ChemicalName Tag Lemon Fragrance (ART11968 from CPL None Concentration MEtehytlhoAxcyemteattheyTefhoxyprapanol FS-Cladsalkanes [7 [364--5To9To7-a 968|| [Copolymer of palekyrlfluaocrroyallaktyelmsoudliffoineadmidfaotyalkayclidacdriymlamteerasnd J oNoonsemsra 7785] "DocuOfmfiecenoftPoPlrloucteisosniPnrgeCveennttieorn Pages. and Toxics : 6232004 bee: 8(e) Committee. Dale LTaormry DBaicPoansq-uEanl~veirOofnfmiecneotaflGLenaebr-al2-C3oEu-n0s9el Johnson -- CT&RS -- 220-2E-02 ~ 220-1 1-02 KCaartohlyLReeyed~ -OcEcuHp&atSiOon-al4M2e-d2ic2i6ne - 220-3W-05 Mike Santoro -- SMD EHSR - 236-18-10 C8h(ee)riCoKoerddrionwastokris- CT&RS - 2202-02 Melinda Mitchell - CT&RS - 220-2E-02 Other MLaarrrlyenZeobMeclG-raMtehdi~c3alMDCepatn.ad~a22--0L-3oWn-d0o5n. RDioegterricPheSrkiinnnsa~eCv--Te&3RMSB-el2g2i0u-m26-02 TDearnesHaakBoersz-ciPkro--tePcrtoitveectCihveemCihcealmsic~a2l3-s6-23168-110B-10 File Information `TTSoxCiAco8l(og)y fniulembneurm:beTr-:797153.1 MBuSsDinSesDsoucn.itNom.a:te1ri8a-l98n5u6m-b8er: 18988, PM-3862