Document 1gV4vEe8DMdbmZJGK8yEmV3po

March 11# 1940 Dr* L. Y* D y r en for t h St* Lu ke's H ospital A ssociation Jack so n v ille # F lo r id a Dear Doctor D yren forth : Th an ks v e r y much fo r you r l e t t e r o f March 5 t h an d f o r you r fu r t h e r r e sp o n se t o my q u e st io n s* I s h a l l b e -very p le a se d t o h ave b r a in t issu e s fo r fu r t h e r exam in ation n ot on ly becau se I sh a ll be glad to check our i n i t i a l r e su lt s, bu t a lso b ecau se fr or i tim e t o time# as op p or tu n ity a ffo r d s i t s e l f , we h ave mad st u d i e s on t h e d i s t r i b u t i o n o f le a d in d iffe r e n t p ar t s of th e b r ain su bstan ce* : I s h a l l be gla d t o sen d you a d e t a i l e d r e p o r t o f our o b se r v a t io n s when co m p le t ed . For th e p r e se n t I m igh t b e st giv e you m erely t h e r e s u l t s o f ou r a n a ly se s on th e t i s s u e s o f H r* The l i v e r , kidn ey# b r a in and lu n g co n t ain e d th e m n Sw ln g r e sp e c t iv e c o n ce n t r at io n s o f le a d in m illigr am s p er 100 gram s o f fi x e d t i s s u e s 2 *0 0 , 0 *6 4 , 1 ,0 8 an d 0 .4 5 , t h e se v a lu e s co r r e sp o n d in g in g e n e r a l t o t h o se w h ich we h ave fou n d in correspon din g t issu e s in acu te fa t a l p oison in g exp erim en tally in duced in an im als, and a lso in acu te f a t a l p o iso n in gs in human b e in g s* In se v e r a l in st a n c e s among ou r r e c o r d e d c a se s th e con cen tration s o f le ad in th ese r e sp e c t iv e t issu e s have b een h igh e r t h an t h e se * On th e o t h e r h an d we h ave h ad oth er c a se s in which th e co n ce n t r at io n s have been o f t h is order o f m agn itude. T h is, th erefore# f i t s in qu ite c le a r ly w ith the t o k ico lo gic p ictu r e o f acu te fa t a l lead p oison in g. . Th ese fi g u r e s a l s o c o in c id e w ith th e c lin ic a l p ictu r e o f t h is m an 's illn e ss. In t h is con n ection you m igh t be in t e r e st e d in th e c l i n i c a l d e sc r ip t io n o f t e t r a e t h y l le a d p o iso n in g# and you m igh t a l so b e I n t e r e st e d in th e b eh avior o f t e t r a e t h y l le a d in th an im al organ ism and in th e d ist r ib u t io n o f su ch le a d in th e t i s s u e s . Accord in g ly I am e n d in g you a few r e p r i n t s wh ich may bo o f i n t e r e s t in t h is con n ection * ; KE" 0021120 - 2- I sh a ll b e v er y h appy to see you when you can e t h r ou gh C in c in n a t i t h e f i r s t o f A p r il. To make c e r t a in t h a t you w i l l n o t m iss me, l e t me warn you t h at I w ill r o t he foun d a t th e h o sp it a l but a t our lab o r at o r y ^ wh ich i s a t th e C o lle ge o f M ed icin e, Eden Avenue, qu ite n ear th e C in cin n ati Gen eral H o sp it al. Very t r u ly y o u r s, R A Kjis Robert; A. Keh oe, M.D. H E 00 21 1?!