Document 1gJkYg8YaJMqX94K6vq6eVnR5

-4lli^S^SiiiiiiifefTfc mwwi I > fiij-jf -iswHariffifi MJfcrf-atifjKn- *.reiiii 1 ri. - % ; ar sutomrrrxx at sumrxiuAxcx or roruiAnon l ias urns or t h e l e a s u a ik x c c mo r o ia t io k a l carm f o r a h roumos ocmot Kavra Hsettn*: October 12, 1967, Dr. Tapper's office, Kettering Laboratory, Unlserelty of Cincinnati. Tiae: 1:00 AiOO p.S. ' Prreent: V. J. Castrop a. J. Mnkt D. 0. foaler C. L. Imw Imb K. K. Hesselberg 0. J. Stoppa !*. J. M. Horton, Cbalraaa L. i. Topper E. Landau (for I. T. Blcaqulat) ItMl: J. I. Ludvig 1. Tt-e futile Health Service bad no additional questions an th protocol for u* U city study. . Kr. rovier had several questions related to the artahollc study. r Terror evplsiaed M ldca fer thts In nor* detail. A special eSll.rd ocean vlll talk with selected arabers of scae of tbs bouse* wife croups xfeo furnish the blood saaples. This will be done after tbs blood saaples, etc., have bees obtained. There Is considerable question that the proposed tuabers will be adequate. In addition to judging the required mater by sequential sampling as the work pro-eede, it >w requested that the Kettertnc statisticians txaalne tie 'lata fras Dr. Kehoe's aetabollc studies for laforaailoe which v -v mIi enhance prediction of the Madders required. j. rurt^r discussion of the use of atonic absorption lead analysis sad it* caparison with the dlthltooe asthod Indicated that the c carperIson pla/w were Inadequate. hellanea should not be placed only on coaparlsc-ns already done at Ketterlnf and elsewhere. Duplicate snslysla by w*b aethods should be carried out on sons (peclarne (l) fro* the r*r(.p of the air filters of the three city study, (2) froa the new air niters froa these c'tles, and ()) fresi the blood speclaena shea tn* are obtained. b. rcciiabllahsant of the old air saapltnf sites and sstabllahasnt of nrv Euipllnc sites will require detailed proj-.-sals by Dr. Tapper to in* :.Mt>craa*|itee. Approval by the Oubctsaaltlee will require future lu-Eil t*, and probably alia visits by all or part of tha aesAer* or f'it r-presenlatlves. Blrv* the selection of appropriate populalloa Is closely related to the aeristetrlc locallor.s this should be M/ iirl in s slatlar aanner, and st the sane llest, If possible. "JW LMlHW-l- p mm msmm WiiMWJiliPU^ ... , X.JiWWii Mp.il> LIA12387 ) n m adiMi--as--Exit--lasiln-- --waaaiii-- ^ . - ;. - -' -...... . - .,fcy.,' .itiiii. ^m^;***^^-****^. - .......................................................... .2 - .... .................. 5. The plana for lnveatl^tlag * low-air-lead city fro* among those la the MSI Bust be developed gradually through exploration, reca--endatloe of tba next tap* to the Bubca--lttee, approval, aad carrying out. The flrat atapa will ba to obtain aad analyse all tha locally avallabla lafor--tlon, especially fraa MSI. Tba following atapa will probably ba visits to one or aora of tba clllaa for further infor--tlon. 6. Dr. Stoppa and Dr. Tapper have both --alned ax lating notarial avallabla to thaa for ralatlooahlp batweea blood load and baaatocrlt. Boos waa found by correlation technique. If this bolds up an further analysis, this ltea will be dropped froa tha protocol. 7> Dr. Stoppa Indicated that they will ba able to rxaalne aaaaonal influence on blood lead lava la aad are prepared to do so. Be will be able to report on this soon. 0. Sow that the Bufrrn--ittae will ba tupernslng tha conduct of a study Instead of planning one, Ita roapoeltlao will require so-- changes aa will Its node of ac* loo and frequency of aeetlngs. In regard to canpo* sit ton, final decisions could no*, ba asde, In all eaaaa. Dr. Bortoa will continue as a Basher aad as chains--, Mr. Caetrop will continue aa a b --*r. Due to reorganisation API repreaentat Ion Is uncertain at this tins. Mr. fowler will continue aa L1A representative) they will have two Other neafeers Nr. Beaaalbarg and Dr. Fahnhe. Dre. Ludwig aad Bloaqulat will ba consulted to see whether or not they wish to continue aa nesfcer* or be replaced. *< 9. The protocol for this study mist to part have gradual develop-- at of Its details. Par this reason, the ca--ittee Bust beve flexll U --thods of 4 being Infer--d of progress, receiving rec rs-- n 1st lone for action, --stag i aad ccamunlcatleg decisions, etc. Dr. Horton sod Dr. Tapper will coor dinate the s'udy. Dr. Tapper will prepare nocthly reports which will cantata Infomattco on progress aad on expectations. The letterlag staff will produce detailed proposals for tha develop--nt of those portions of the protocol Milch are not established in advance. These will be sub* anted by Dr. Tapper to Dr. Horton either la a aenthly report or separately. Dr. Bortoa will suhnlt all proposals to tha --ere of the aubcaaalttee by the Boat expeditious aeons practical, and vl 11 obtata approval as quickly aa poasibla. Tba slaplast appropriate --asures *111 be takes to arrive at decisions, but It Is appareot that Beatings, visits, etc., will s o bs * 11-- be required. 10. A nev cusp leta protocol for tha study aa far as Is now agreed upon should ba obstructed for various rew m, particularly for Basing the for--1 contracts Dre. kortcxi and 7pper will attest to produce s satisfactory doc--ant for approval. 11. Tbs A-- rlcsn retro'.*'-- Institute, Tba lead Industries Association and tha Public Health Service will each contribute #70,000,00 to tha support of this contract. Tha actual contracting arrange--at* will ba instituted and c<*plated as soon as poet lb la. wye 'I*'