Document 1QovrKvMy3nY4bK0weXaXRoYj

....... ^ MINUTES AROCLOR - WILDLIFE; REVIEW OF BIO-TEST STUDIES MONSANTO .GENERAL OFFICES MEDICAL DEPARTMENT ST. LOUIS, MISSOURI September 19, 1969 TO: Those Present M. W. Farrar W. H. Hunt R. E. Keller R. E. Kelly Tucker Wheeler Not Present W. R. Richard The above attendees reviewed with 0. E. Fancher, Director, Industrial Bio-Test Laboratories, the biological results . to date of their feeding studies and., the, consolidation of tissue samples for residue analysis by the Analytical Group of the Applied Sciences Section. DSW 552543 STLCOPCB4090960 2- - A. detailed analysis of the currently planned analytical support work for the Aroclor - Wildlife project was prepared for this meeting. Table I. The analysis includes a listing of studies, manpower requirements and a dollar cost for the analytical support of each study. In brief, it was ascertained that there were at least five separate Bio-Test feeding studies in progress or planned which would require 105 man weeks to analyze the estimated 1340 samples being generated, at a cost of $63,000. An additional $18,000 of work not involving Bio-Test is also outlined in the Table. Meeting Objectives ' I. Review Bio-Test feeding studies with special regard to the scheduling and reduction of the number of samples to be analyzed. . II. Status review of the biological results, to date, of Aroclor - Wildlife Bio-Test feeding studies. With these facts in mind, each Bio-Test study listed in Table I was critically reviewed to determine if the number of samples requiring residue analysis could be decreased without appreciably effecting the results. . --4 1. Rat Tissue Study - Actions: - Delete residue analysis of rats fed chlorinated naphthalenes and pesticides. Pool male and female animals. 2. Chicken Toxicity, Reproduction, and Meat and Egg Residue . Study -. Actions: -- Pool larger numbers of eggs. -- Analyze only fat,- muscle-,- and. liver tissues. ' . . - Restrict analysis to one-, no effect . level for each Aroclor. . 3. Mallard Duck Study Action: - Equivalent to Study No. 2. 4. Two Year Chronic Toxicity in Rats Actions: - Delete 9 month sacrifice. . DSW 552544 STLCOPCB4090961 '^y . -3- ' ' . - `. Actions: - Pool all male and female animals. (Cont'd) . - Restrict analysis to one, no effect level . for each Aroclor. 5. Fish Toxicity Study . Actions: - None; study design requires this number of samples. - 6. Rat Reproduction Study '. Actions: - Addition of 2nd litter, 1st generation, rat pups to be analyzed. 7. Two Year Chronic Toxicity Study in Dogs ; Actions: - Addition of selected tissues for residue analysis. TABLE II AROCLOR - WILDLIFE ANALYTICAL SUPPORT REVISED (Bio-Test Section Only) ` No. Samples I. Residue Determinations A. /. 'a / .3 Biological Residues (Bio-Test) ) . -'y( i. Rat Tissue Study 40 2. Chicken Toxicity, Reproduction, and Meat and Egg Residue Study -96 3. Mallard' Duck' Study 96 4. Two Year Chronic Toxicity- in Rats 160 5. Fish Toxicity Study 60 6. Rat Reproduction Study 10 7. Two Year Chronic Toxicity Study in Dogs 40 502 Man Weeks $ Cost 3 1,800 S 8 4,800 - 8* 4,800 12 7,200 ' 9 5,400 1 600 3C-- 3 1,800 35-.-. 44 26,400 DSVJ 552545 STLCOPCB4090962 w 4- It is important to note that neither Table I nor the revision take into account work done by the Spectroscopy Group (GC/Mass) duplicate analysis of samples, nor any additional method . development required. .. The results, to date, of the biological studies were issued in progress reports distributed by Dr. Fancher. Additionally, arrangements were made to have Bio-Test store tissue samples in Chicago until they can be analyzed. db Attachment E. S. Tucker oS'H STLCOPCB4090963 ~ I. Residue Determinations J ' . Charges ' Samples A. Biological Residues (Bio-Test) 1. Rat Tissue Study 2. Chicken Toxicity/ Reproduction and Meat and Egg Residue Study 3. Mallard Duck Study 4. Two Year Chronic Toxicity in Rats 5. Fish Toxicity Study Reg. Reg. Reg. Reg. Reg. . 160 360 360 400 60+ 1,340 B. Environmental Residues 1. Outside a. Lake Michigan WARF Study b. Detergents & Components Reg. 12+MD Inorg. 20+MD i'iUll Weeks 12 27 27 30 9 10 5 2 3 2. Monsanto a. Anniston - Water/ Sediment/Fish b. WGK - Water/Sediment . c. Pensacola - Water/ Sediment/Fish d. Ruabon - Sediment e. Florida - Soil Poison Test Samples (Soil) Mfg. Mfg. Reg. Reg. Reg. II. Special Studies A. Ultraviolet Degradation of PCBs, et al B. Water Extractability of PCBs from Painted Surface C. Characterization of Competitive PCB Products D. Analysis of Auto Exhausts for PCBs E. Analysis of Pesticides forPCBs F. Determination of the Quarter Phenyl Content of Aroclor 5460 Reg. Reg. Reg. Rag,.. Reg-. Reg>. 14 in hand 13 in hand 12 in hand 4 in hand 45 X 2 165 1 1 1 1 5 14 MD MD MD MD MIT MD, ". 4 3 1 L. T 4 16 Cost ($) 7,200 16,200* 16,200 18,000 5,400 63,000 1,200 1,800 600 600 600 600 3,000 8,400 2,400 1,800 600 600 1,800 2,400 9,600 TOTALS: 1505 135 81,000 . Assumption - 3 hr. /sample $15/hr. = $600/wk. MD - Method Development 0S\N 552547 STLCOPCB4090964