Document 1QdvrVn34Y4EEdb2Y7Ve6qM5d

CONFIDENTIAL World Register of Cases of ANGIOSARCOMA OF THE LIVER (ASL) due to VCM REVIEW DATE 1st JANUARY 1990 ^^^^^^^^^ Collated by: Dr Brian Bennett Occupational Health TCI Chemicals and Polymers Ltd Hi 11house Site PO Box 4 Thorn ton-Cleveleys (Telephone Blackpool FY5 400 (Telex England (Fax 0253 861632 } 674B3ICIPLHG) 0253 861861 ) GENC 008254 LIVER ANGIOSARCOMA CASES CIRCULATION OF REGISTER CONFIDENTIAL FEBRUARY 1990 BAGSHAW Dr I M M BAND Dr P R BARRAT Dr G BAXTER Dr P BAYLAC Dr BELLEC Dr BENECH Dr M BENNETT Dr B BERTAZZI Dr P BERTUZZI M BEYNON D W S BISHOP Dr C BORRELLI F E BRAUN Dr C L J BROGDEN M E BROWN Dr M G BYREN Dr David CAMPION Dr Catherine CARTER Dr J T CATANZARITI A CELLA C CHANCE M CLARKE Dr E A CLAYTON H CONTASSOT Dr J C DAVIES J G DELORME Dr F DEPLAN Dr F DIETZ Dr H W DOLL Prof Sir Richard DOMBROWSKI S L S DOORNBOS Dr N DRUMWRIGHT Dr J R DUPONT G EMMINGER H ERNST Dr W EVANS Dr A E J FALK Dr H FARMERY Dr K FAVRE Dr FIELDING Miss C Hydro Polymers Ltd, Newton Aycliffe, UK Cancer Control Agency of British Columbia, Vacouver, Canada AECRP, Commentry, France University of Cambridge UK Atochem, Chauny, France Rhone Poulenc, Aubervillers, France Naphtachimie, Lavera, France ICI Hillhouse, UK Inst of Occupational Health, Milan University, Italy EVC, Brussels, Belgium ICI Runcorn, UK EMAS, Cardiff, UK Georgia Gulf, Delaware City, USA Akzo, Arnhem, The Netherlands ICI Runcorn, UK Shell, An Den Haag, The Netherlands Nobel Industrier, Sundsvall, Sweden Health & Safety Executive, Bootle, UK EMAS, London, UK EVC, Brussels, Belgium EVC, Brussels, Belgium ICI Runcorn, UK Ontario Cancer Foundation, Toronto, Canada Norsk Hydro, Newton Aycliffe, UK Atochem, Saint-Fons, France EVC, Brussels, Belgium Quebec, Canada Atochem, Jarrie, France B F Goodrich, Akron, Ohio, USA Imperial Cancer Research Fund, Oxford University, UK Dow Chemical, Midland, Michigan, USA DSM, Beek, The Netherlands Vista Chemical, Houston, Texas, USA APME, Brussels, Belgium VKE, Frankfurt, Germany Berufsgenossenschaft der Chemischen Industries, Nurnberg, Germany Lever Bros, Warrington, UK Centers for Disease Control, Atlanta, Georgia, USA ICI Hillhouse, UK Atochem, Montluel, France ICI Millbank, London, UK GENC 008255 FILLINGER J FINCHAM Ms Shirley FOA Prof V FORMAN Dr D FRASE R W FREIESLEBEN Dr W FRIEDEL Dr H P GAFFEY Dr W GIUDICE Dr S GOTTESMAN Dr R T GROISMAN D HILLMAN Dr D W HOWARD Dr J K HOWE Dr W HUMPHRY Dr N F JOHNSON Dr C A JOHNSON Roy N KAIPERT Dr J H KALNAS Dr J KLEIN Dr H LAGAST Dr H LANHAM Dr John LANOUZIERE Dr Claudine LAWRENCE-JONES Sir C LEE Dr F I LEESER Dr Jenny LELBACH Prof Dr WK LEVEQUE Dr G LEVISON Prof Dr D A LEWIS Dr P LIGO Dr R N LO MARTIRE Prof N LUSS R D LUSSATO Dr Josette MALTONI Prof C MATTIUSSI Dr R MELTON B MIDDLETON D MOKKA Mr MONTESANO Dr R MOTTI Dr A A MUNOZ MOUTON Dr M MacSWEEN Prof RNM NAKAMURA Dr S OSMAN Dr J PADDLE Dr G M 2 Solvay, Brussels, Belgium Alberta Cancer Board, Edmonton, Canada Inst Industrial Medicine, Milan, Italy Imperial Cancer Research Fund, Oxford University, UK DiversiTech General, Akron, Ohio, USA ECVM, Brussels, Belgium Berufsgenossenschaft der Chemischen Industries, Heidelberg, Germany Monsanto Co, St Louis, Missouri, USA Montedipe, Venice, Italy The Vinyl Institute, Wayne, NJ, USA Electrochemical Industries, Acre, Israel Diamond Shamrock Corp, Dallas, Texas, USA University of Otago School of Medicine, Wellington, New Zealand ICI Runcorn, UK ICI Australia, Melbourne, Australia Goodyear Tire and Rubber, Akron, Ohio, USA GenCorp, Fairlawn, Ohio, USA Dow Chemical Europe, Horgen, Switzerland Imperial Oil, Sarnia, Ontario, Canada Dynamit Nobel, Troisdorf, Germany Solvay, Brussels, Belgium Dow Chemical, Midland, Michigan, USA Solvay, Tavaux, France Chief Medical Officer, ICI, London, UK Victoria Hospital, Blackpool, Lancs, UK ICI Runcorn, UK University of Bonn, West Germany CDF Chimie, AZF, Bully-les-Mines, France Guy's Hospital, London, UK Chemical Industries Association, London, UK Dupont, Wilmington, Delaware, USA EniChem, Milan, Italy Occidental Chemical, Pottstown, Pennsylvania, USA Atochem, Port de Bouc, France Institute di Oncologia, Bologna, Italy Montedison, fifilan, Italy Formosa Plastics, Delaware City, USA Hydro Polymers Ltd, Newton Aycliffe, UK Neste Oy, Espoo, Finland IARC, Lyon, France ICI Duperial, Buenos Aires, Argentina Rio Rodano, Madrid, Spain Western Infirmary, Glasgow, Scotland Japanese PVC Association, Tokyo, Japan Health & Safety Executive, Bootle, UK ICI Central Medical Group, Alderley Park, UK GENC 008256 3 PAQUET Dr Christiane PATERSON Dr J C PIRASTU Dr Roberta POSSBERG Dr J PUECH Dr A M PURDHAM Dr J RAMBAUD Dr J RICHARD Dr A ROBSON Mrs D ROSA Dr HS RUTY Dr J SALG Dr Joyce A SCHIPPER Dr H SCHUCKMANN Dr F SERONNE Dr D SHAH Dr Has SIGRIST Dr J SMITH Prof Allan H SMITH Dr P M SPIRTAS Dr R STAFFORD Dr J STAHNECKER Dr E SULAIMAN Dr TACHECI Dr H TAMBURRO Prof CH TENKHOFF Dr N TEPPER Dr L B TERWIESCH Dr B THERIAULT Dr Gilles THIIS-EVENSEN Dr E THOMSON Dr D H TOMATIS Dr L TONER H P VAN DER MERWE Dr H J WALTEMATE H WEJDLING S 0 WILLIAMS Dr DMJ WILSON Prof R YORK J ZOBER Dr M A Atochem, Serquigny, France ICI Runcorn, UK Istituto Superiore di Sanita, Rome, Italy Wacker-Chemie, Munich, Germany Atochem, Brignoud, France University of Toronto, Ontario, Canada RP Recherches, Antony, France Rhone Poulenc, Roussillon, France Saskatchewan Cancer Foundation, Regina, Canada Petroquimica, Salvador, Brazil Atochem, St Auban, France NIOSH, Cincinnati, Ohio, USA University of Manitoba, Winnipeg, Canada Hoechst, Frankfurt, Germany Diamond Shamrock, Dallas, USA CMA, Washington DC, USA Shell Chimie, Berre L'Etang, France University of California, Berkeley, USA Llandough Hospital, Penarth, UK NCI/NIH, Bethesda, Maryland, USA Somerset, UK BASF, Ludwigshafen, Germany Arabian Petrochemical Co, Saudi Arabia Hoechst AG, Frankfurt, Germany University of Louisville, Kentucky, USA Huls AG, Marl, Germany Air Products, Allentown, Pennsylvania, USA Huls AG, Marl, Germany McGill University, Montreal, Canada Norsk Hydro, Porsgrunn, Norway Cancer Treatment & Research Foundation, Halifax, NS, Canada IARC, Lyon, France Society of the Plastics Industry, Washington DC, USA AECI, Sasolburg, South Africa BF Goodrich, Cleveland, Ohio, USA Norsk Hydro, Stenungsund, Sweden BP Chemicals International, Barry, UK Harvard University, Cambridge, Massachusetts, USA EVC, Brussels, Belgium BASF, Ludwigshafen, Germany From: Dr B Bennett, Occupational Health, ICI Chemicals & Polymers, Hillhouse Site, PO Box 4, Thornton-Cleveleys, Blackpool, FY5 4QD England GENC 008257 REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVER DUE TO EXPOSURE TO VINYL CHLORIDE - REVIEW DATE 1 JANUARY 1990 PREFACE : ACKNOWLEDGEMENTS, SIGNIFICANT CHANGES, COMMENTS AND REQUESTS 1 The 14 new cases in this Register are: France 26, 27, 28; Germany 33, 34, 35, 36, 37, 38, 39; Spain 01; UK17, US 42,43. The Spanish case is the first notified from that country. 2 The following 2 cases have been deleted from the Register: Germany 26 (Alcoholic Cirrhosis), US24 (Cholangiosarcoma). 3 There are amendments from the previous Register against cases: France 22, 23, 24; Germany 31, 32; US33, 34. 4 I thank the following'for information about new cases: Drs Lagast, Contassot, Friedel, Tenkhoff, Lee, Hamill and Mr Roy N Johnson. For information about other cases I thank Drs Dietz, Fendel, Smith and Williams. 5 So far as I know the following are still alive: France 15 and 28; US33 and 36. I am grateful for information on this subject in the past year, and urgently need to be kept up-to-date, please. 6 In Table 3 I have now treated a 'cluster' as 3 cases instead of 2, due to the passage of time and the increased number of cases in the world. 7 Tables 4E to 4H have been amended, as the number of cases per factory has altered. 8 A new Table 16 has been introduced showing the number of PVC factories in the world so far as known to me. Please keep me informed of any alterations in ownership, openings, re-openings or closures (see Tables 8 to 15). 9 The initials of case UK05 have been amended to RK (not JK). It will be seen that certain cases have no initials against them. Can anyone please help with this? Some of the countries concerned are Belgium, Czechoslovakia, France, Sweden, the US and Yugoslavia. 10 CHOLANGIOSARCOMA As stated above I have deleted US24 which was a Cholangiosarcoma, not an Angiosarcoma. I "have heard of another case of Cholangiosarcoma but the significance of these cases is not apparent in connection with VCM. I should be grateful if anyone who knows of any other case where the patient does develop Cholangiosarcoma with VCM exposure, would inform me about it. 11 RESEARCH Please keep me informed of all relevant research and if possible send me copies of Reports. Would recipients of the Register please pass on this request. 12 Please also notify me of all changes relevant to the Register and especially new cases, for which a blank sheet is provided at the back of the Register. FROM: Dr Brian Bennett, Occupational Health, ICI Chemicals and Polymers Limited, Hillhouse Site, PO Box 4, Thornton-Cleveleys, Blackpool, FY5 4QD, England February 1990 BB/BGS GENC 008258 INDEX Tahl c Sequence BeIgium Canada Czechoslovakia France Germany Italy Japan Norway Spain Sweden UK USA Yugoslavia Incidence of Cases per annum (Table i) Distribution of Cases by Country (Table 2) Pattern of Cases by Factory (Table 3) Latency Periods (Table 4A) Distribution of Latency Periods (Tables 4B-4H} Annual Geographical Incidence (Tab Le 5) b I VEH ANCi 1 OSAKCOMA CASKS (REVIEW DATE - JANUARY 1990} 1 1 I'.iilb 1 | 1 i ASI. Case Numbers by year of Death [ 2-3 1 (Table 6) 1 ASL Case Numbers by year of first exposure 4I 1 (Table 7) 5-10 1 Western Europe PVC Producers - Start-up Dates vs ASL Cases 11-18 1 1 (Table 8} 1 USA PVC Producers - Start-up Dates vs ASL Cases 19-20 1 1 (Table 9) 21 1 Canadian PVC Producers - Start-up Dates vs ASL Cases 1 22 1 (Table 10) 1 East Furopean PVC Producers - Start-up Dates vs ASL Cases 23 1 1 (Table 11) 24 1 Japanese PVC Producers - Start-up Dates vs ASL Cases 25-29 1 1 (Table 12) i South & Central American PVC Producers - Start-up Dates 30-38 1 (Table 13) 39 1 Australasian PVC Producers - Start-up Dates i 40 1 (Table 14) 1 Middle Eastern PVC Producers - Start-up Dates ! 41 ! (Table 15) 1 Number of PVC Factories in the World 1 42 1 (Table 16) 1 1 Blank form for notifying new cases 43 1 44-50 1 1 1 1 51 1 1 Pago 52. 53 54-55 56-57 58 59 60 61 62 63 64 Page /. CANADA Sheet 1 LEVKJ? Amjiosrn rtTM Cases - (Re^ew Dale: I l,in 199(1) day - month - ukr AH rliitcji use UK systc ! -j------------------ 1---------------------- 1------------------- r 1 |7 1J1 -i 1 s 1 f, J 1 COUNTRY AND f JI______________ ____________ L 11 I} MAKE OR 1 DATE 01 f | J FIRST VC REFERENCE j INITIALS | BrfiTH | CHRPAMY | FACTORY | EXPOSURE WO CANADA l j 1 l 11 J1 J___________________________ ____________ L II 11 1 [ SHAWimGAJi I 1 JJ ii Ot 1 1 [lb.[2.1.1 | 11 | | 1944 !J -l-----------------1 If 02 1 |06.03.14 | 1 Ii 11 || ii 1943 1 II II j-----------------1 Jj______________ ____________ L ll II 03 1 126.08.19 | | j 1941 1 11 II ! il l1 j------------------ J___________________________ _____________L 1 II II 04 1 (05-04.19 1 | | 1945 1 1! II i II II 1 j 1 05 1 I ff 11 J____________ _______________ ____________ i_ II It f07 - 05.1] 1 II ii ii 1944 1 j 1 00 1 1 1 1 07 1 1 11 II |15-12.19 | ii ii i11i |Q9.11-19 | ll 11 II || ii i^,i if 1 i || ll 1947 1946 f j 1 03 1 1 Jr 09 i i El ll ll Il3.05.20 | iI 1 t1 |19-07.21 | ll i1 ii II || ii iIiI |j ii 1961 1946 ! i iI Ii j____________J----------------- 1______________ [____________L. ! 11H 1 1 DATE 0E l AGE AT 1 19 | 1 1 YEARS OF 1 111 1 10 --------- r 1 n------------------------- i------------------------------ 12 1 13 J 14 1 15 1 ! |1 --1 1 r i ---------------------------r--------------------- f 1---------------------- i1------------------------- 1 t f YEARS OF | DATE OF j HISTOLOGICAL j ESTIMATED | f OTHER | GTHEfl DIAGNOSIS 1 DIAGNOSIS | EXPOSURE TO i EXPOSURE | DEATH | CONFIRMATION | EXPOSURE | OCCUPATION j CAREER [ COWENTS 1 1 1 l 1955 l 41 J DIAGNOSIS 1 1I | i 11 ( 1 1r 1 f 11 I i 1f l 11 i 11 j02.09.55 j Yes 1 LEVEL l | HIGHLIGHTS 1 j r r i---------------------- ir------------------------- il------------------------------ 11 1 f1 I 1 | Reactor {Operator | Smoker 11 1 |1 1957 1 43 f 14 1 1i i r1 rr i 14 l2L.12.67 | Yes 1 l r 1 [cleaner (polymerisation! -jl---------------------1------------------------- 1------------------------------ (Maintenance ,(Operator [Worked ll i 11 1 [mi llwright. [overtime 1f 1962 1 42 I 21 1f i 11------------------1-r i 20 |23.03.62 | Yes [ 1 r 1 (pipefitter -fI---------------------- (Operator, [Smoker H------------------------------ |Worked 11 i II 1 (foreman [overtime 1967 1 l 48 f 22 ll I --r|------------------i 1_ 1 --r i 72 121.01.68 | Yes 1 ii |Non-smoker I n---------------------- 1i--------------------------Ht------------------------------ JReactor (Operator, [Worked l1 i II 1 |cleaner [foreman. (overtime 1l i ii 1i (rater cooling [Smoker I960 1 lI 1 | 1l 1 1 T 1-------------------r --r 57 1 24 1 05 105.07.68 | Yes 1 I (unit l H-----------------------1----------------------------1----------------------------- (Reactor [Hater cooling |HorJced I[ 1 11 1971 1 1i 1 X --ji----------------- jf- 51 1 24 1 23 f10.04.71 | Yes 1 1 r 1 [cleaner (unit i r 1----------------------- [Reactor [Maintenance, [overtime jSmoker i----------------------------- | Worked * l1 1 lI 1 |cleaner (millwright [overtime 1972 1 --f|- 53 1 26 1 1I -r --1------------------ r 1 25 |24.12.72 | 1 1 --r Yes 1 i I1 [Reactor | Machine shop |Smoker l 1------------------------------ [Worked l1 1 11 1 (cleaner (operator and j overt ime 1973 | T ! 53 1 (r l 12 1 11 | + --[----------------- h 1 05 Il2.06.73 | 1 1 --r Yes 1 1 [poly unit I 1----------------------- |Reactor | Maintenance (Smoker 1 1------------------------------ j Ln plant i( 1 ll 1 ii i f ------l1------------------I 1_ -r 1 --r 1974 i 53 i 28 1 26 j04.09.74 | Yes 1 [cleaner (machine shop [2S yrsl Smoker i----------------------[Furnace op. H-----------------------------[Worked ii 1 ll ( (pipef Ltter (overtime i1 i 1 ll I I1 1 [maintenance j I (Smoker t * Paper by Dr F DELORKE in Annales d'Ariatomio pathologique Paris, 1978 Vol 23 No 2 ppl05- 114 claims this case had both a hepalcma and ASL simultaneously. GEHC 008261 Prjge --Sheet l -- 1 ] ---2 -- 1---3 --1 CDtHTTRY AND NAME OR DATE OF | REFERENCE INITIALS BIRTH NO ! CANADA -- ------------------1 1 1 10 16.05.IS 1 l -- ----- --i 1 4 COMPANY 11 LG 13.10.2S Gulf l I i ------------------- 1 1 1 12 BC 14.09.20 Gulf I i I i i i I 1 | I 1 i 13 SS 10,06.26 BFG i i i DAY - HONTi 8 - YEAR A I I dates use (JK system ,S I I YFR ftmj I'jsan' (Review Dale: 1 Jan 1990) ------- ,----- l------------------ 1 ---------------------- 1 -- -- 67a fJ | 10 11 ____ ____12 13 M 1 15 16 FACTORY FIRST VC EXPOSURE 1 Shavinigan 1953 DATE OF DIAGNOSIS 1976 AGE AT DIAGNOSIS 61 YEARS OF j YEARS OF EXPOSURE TO | EXPOSURE DIAGNOSIS | | l ! i DATE OF DEATH 23 | 14 00*04.77 HISTOLOGICAL CONFIRMATION Yes ESTIMATED | EXPOSURE OCCUPATION ____LEVEL OTHER CAREER HIGHLIGHTS Reactor Furnace op. OTHER CQttGXTS Ex-smoker i-------------------I l cleaner maintenance, ____ ____ _____1 packaging 11 1 1 Shawinigao 1943 Nov 65 60 42 [ 5 05.04.66 Yes High 1943-47 Retired 1972 Letters free l | Operator & {Age 47) Dr Fernand l JSupervisor Delorme, ! 1 VC Plant Pathologist & Shawinigan 1945 Mar 62 61 1 t 11 37 [ 27 31.03.82 Yes 1 High 1945-55 H Bi-beau, BFG Retired 1972 Letters free ! Autoclave (Age 52) Dr Fernand 1 Operator, Delorme, 1 PVC Resins Pathologist & 1 H Bii>eau, BFG f Low 1955-65 1 VC 1 Manufacture Niagara Welland 1957 1967 60 1 i i i I i 30 | 23 26,1.07 ! 1 1 ] Nediin 11965-72 \Autoclave |Operator, _____|PVC Resins ______________ 11________________1 Yes 1957-70 (Poll Cleaner Retired I960 Information High 6 Operator (Age 54) free Dr H W Dietz, 1970-00 Supervisor BFG, 1968 Eiow li i l 1 l I i i ! _____________ i____________ ____________1_____________ 1 ______________ i 1 1 1 1 1 1 1 i . ____l i__________________L CZECHOSLOVAKIA LIVER Angji ^sarcoma Cases - (Review Date I .Jam 90) country and REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY U> 13 16 FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER \ CAREER J HIGHLIGHTS | OTHER COMMENTS CZECHOSLO VAKIA 01 2S.06.28 State Co Novaky 01.07.57 24.12*73 24.12.73 Autoclave Cleaner |lARC letter of (l-4-82 giving [details from jprof A David |of Centre Ind |Hygiene and jOcc 06.07.27 Novaky 01.11.50 27.11.64 26.11.64 Yes Autoclave Cleaner I jlARC letter of 11-4-82 gave i somewhat Jaltered dates (for this case. |I have [accepted the [changes since [the dates come |from Prof ]A David of the |Centre of [industrial [Hygiene and [Occupational (Diseases. My | dates cane |originally | frcm NIOSH. GENC 00826 FRANCE Sheet. 1 Ir iI 4 I LIVER Angiosarcoma Cases - (Review Date: 1 Jan 90) U 15 COUNTRY AND J NAME Oft REFERENCE | INITIALS HO I DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT j YEARS OF DIAGNOSIS [ EXPOSURE TO I DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OTHER CAREER HIGHLIGHTS OTHER COWENTS 01 I* 15.04.24 Rouss illon 00.01.46 18.02.67 19 19.02.67 Yes High Autoclave worker aod cleaner 19 jrs ( ) j | Ref. Ravier et al Arch. Hal. Prof. 1 30 n~ 3 Nov 75 p 171-177 02 SIM 03.06,11 PCUK Britpoud 06.07.59 15.01.75 16 12 24.01.75 Yes High 2 yrs on jItalian Ref. (HIOSH no |origin G Boonetoo et cement) 10 jrs on lal "Houvelle polymer isation reedicale" 5 Nov 1977 p 735 03 NAV 06.01,20 St Fons 00.00,46 15.01.75 55 29 29 29.06.75 High Polyworker: }VCM production Ref, Retj et 10 jrs as f16 yrs. al Arch. Mai. autoclave |ltalian PCH. Prof. 1 37 o' cleaner, (Shepherd, 6 June 7? Confounding |Sawyer, Mason ip 551-555 3 jrs | 27.01.27 Brignoud 19.10,49 16.01.76 49 26 26 04.01.76 High Honcner production worker 0 jrs. Jpitc filtration 18 yrs 05 29.01.38 Brignoud 18.01.65 13.05.76 38 13.05.76 High Polyworker II jrs 11 }Tboracotaoy [Ref. P Coodere 19th Peb 1976 |et al "Semaine (costal jdes hospitaux | angiosarcoma J10 Septeahre J 2) Sc intigraphjf1976 |found ASL |Previouslj had |3)Kaeoorrbage Jbooe [fraa ASL |4)Righl langiosarcons'1 [Also |Hepatectonj fpilichowski et 1 [al ,rLa Nouvelle 1 jpresse Medicate' f7th JuJj 1979 'Page 2485. Page (> FRANCK UVKH Ang inj^it c-or&j Cujn's - (Review Dale* l .lin tlJ9G) Sheet 2 1-- 1 1 !\ 1 2 |3 4 15 6 COUNTRY AMD 1 l NAME OR | DATE OF J 1 1 FIRST VC REFERENCE INITIALS I BIRTH COMPANY | FACTORY EXPOSURE NO I 1 06 Pa i____________ 1 |14.04.34 PCUX f1 jBrignoud 01.03.58 li 7 DATE OF DIAGNOSIS 12.08.76 -- 1 9 9 AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS 42 18 10 1 H \ ~i--------------------12 i 13 i H i --------------------J1----------J-------- 1 i YEARS OP | DATE OF HISTOLOGICAL ESTIMATED | | EXPOSURE j DEATH CONFIRMATION EXPOSURE | OCCUPATION | 1 LEVEL 1 | 11 i1--------------------- 13 |ll.09.76 j(NIOSH Yes Moderate 1(1958-1960) |2 its i5 OTHER ~i----------------------------1 16 1 n----------------------------- | OTHER CAREER j C0(*fENTS HIGHLIGHTS 1 1 ----------------------------- [This man bad |AOL prior to Ii [says jfiltratioo (AS. Ann. de li II (12.09.76) i j10-11 yrs |polyworker jHal. Prof. jJuly '77 ii Ii i |and works |p 645 6 6. i jlab? |AOL was found li i 1 jin 1971 five 1i [ 1 |yrs before i1 1 1 Jasl i J| 1i _|i------------------ i1---------------------- l n----------------------------- 07 GIR |26.04.27 RP | St Auban 01.07.50 After 40 26 22 |02.07.76 Yes High |Plant fore- 11972-6 attain [Died of !l death I (NIOSH no |man in |section in (septicaemia 1I NJGSH i conment} (polymer- j St Auban |Small liver 1i says i jisat Lon [lesion found 11 00.07.76 1 l [after autopsy 1 J1 1 ! n------------------ 1 H------------------------ 1-------------------------n----------------------------- 08 B (01.04.34 Solvay |lavaux 23.05.57 03.12.75 42 19 19 |30.01.77 Yes Moderate |6 yrs packer| |llad been lI I |& autoclave |tunnel worker Ii I |clnr [previously I[ i |14 yrs I Ii l [autoclave I f1 l | worker t 09 RFX f \ |08.1G.14 RP 1 ! JSt Poos 10.01.48 26.04.76 63 28 I T 28 |25.12.77 ---------------------- 1---------------------- 11 Yes Very High | Polymer- j10 yrs in (Operated 4.76 Il 1 1948-1966 (isation (sulphuric |for removal of lI 1 Lesser (operator. |acid factory. | tumour from (i 1 Exposure |autocleaner (storekeeper |liver and tI 1 1966-1976 | autoclave | general |died after lj 1 | maintenance |services [second li 1 i |surgical lI ; [ (operation for Ii i i |Wlio Ii i i (bronchial Ii i i |fistula ii i [ (Paper by II i i fDr Retj et al 1i i i jin Archives de Ii i [ |Haiades li i i [Professionals II i i flfol 40 Ho 6 lI i i f1979 pages i j l i iI 1 -i |741-3. _________ FRANCE - Sheet 3 [3 LIVER ArKfio^rcfma Cases - (Review Dele. 1 Jan 1 990) ii r oj / n 14 COUNTRY AND REFERENCE HO NAME OR INITIALS DATE OF BIRTH 10 24.05.19 FIRST VC EXPOSURE 00.12.56 DATE OF DIAGNOSIS AGE AT DIAGNOSIS 53 YEARS OF j YEARS OF EXPOSURE TO | EXPOSURE DIAGNOSIS j f I DATE OF DEATH 10.01.78 HISTOLOGICAL CONFIRMATION ESTIMATED | EXPOSURE f OCCUPATION LEVEL j OTHER CAREER HIGHLIGHTS High [Autoclave I cleaner 10 yrs in mechanical engineering industry 1946-1956 OTHER COWtENTS Died of pulmonary eaboliso) 5 days after surgery 15.02.12 12.08.78 I High [1941-1.946 |polymerjisation |general [purpose |worker, j1946-1972 JVCN [synthesis | < HC1 & | Acetylene) | Foreman |(agent [de fiaitrise) 11972 Iretired Srignoud 30 j 27 23.06.79 | Yes II I High jMonomer [production [and polymer isation operator 13 19.01.31 Solvay 23.09.63 26.06.79 I 05-04-24 | Chloe | [ Chi due | f tFormerly I i SP) II II O0.07.B1 22.08.79 | 11 1I 11 11 1! [1 1! 11 [1 1I j |29.07.81 | 11 l1 JJ Yes J Autocleaner |2 yrs as cycle [Cigarette ! |2 rrs. [mechanic. | sacker until [ |Auto- [10 yrs as J1974. Ill all J [operator [enameller in jof 1977 due to i |9 Yrs, [sanitary ware [Oesophageal | | Copolymers [manufacture [varices. 1 H rrs i [Surgical 11 I [intervention 1 .[ i |25.05.79 11 i 1(right 1----[ 1 | Very High |t943-]9?5 t |1975-1979 Jbepatoclcny) 1 Yes [ 1943-1975 [Ail types of[maintenance i | artd |jobs on [work i f Inlermi t t-[manufacture 1 I J entiy Js maintenance f 1975-1979 ftn VCM Poly | J f Prtx'ess f J____________I_____________ u P.Aje 8 FRANCE Shout 4 l.rVKR Angiosarcoma Cases - (Review Date; 1 Jan 1 >i 11 COUNTRY AND | REFERENCE | 1T 2 [^ 1 i| \ NAME OR | DATE OF INITIALS [ BIRTH 1 * COMPANY iiT 1 5 16 1 7 J !l 1 1 | FIRST VC DATE OF 0 AGE AT 1 11 1 9 1 id 1 U f 1 _L _J ni 1 YEARS OF |YEARS 0F| DATE OF | FACTORY | EXPOSURE 1 DIAGNOSIS l DIAGNOSIS [EXPOSURE TO 1 EXPOSURE| DEATO J1 1 12 | 13 | 14 1 1| 1t HISTOLOGICAL | ESTIMATED | f CONFIRMATION j EXPOSURE j OCCUPATION j js OTHER CAREER 1 1 16 11 | OTHER | C0WIENTS NO 1 1 11 1------------------ 1 15 | DEP [03.01.37 Chloe l 1 1 |St Fons 1 f _L 1 [ 07.07.55 |28.09.82 1 DIAGNOSIS 1 1 f 11 l 11 45 1 27 1 27 |Alive j LEVEL | [ HIGHLIGHTS ! ff 1t 1 Yes j High-20 yr [Autoclave [Left Hepatectonry l ! 1 Chime [ I l i l lI [Moderate [cleaner (1983. l I 1 (formerly | [ I l l l i [7 yrs |1955-1962 I l l i RP) i I I I li [ [autoclave |j C Contassot l 1 11 16 \gxk 1[ [ l \ [l3.07.22 Chloe 1 i 11 Jst Eons tI [ |t | 17.10.41 05.01.03 l 61 I 41 li 1 11 38 |03.04.83 | [operator j [1962-1982 (1 fi Yes [High-33 yrsjpolyaerisat [Letters of 5 10 83 land 29 7 88. 11 |Retired 1 i 1 Chime | i j I i ]I |rtoderate- [ion Process [Jan 1979. 1 i 1 (Formerly | I I i i 1 I |Low - 5 yrs|fen |j C Contassot 1 i 1 RP) i i i i Ii ii [Letters of 1 i1 1i i i i ii | [Maintenance |5 10 1983 and 1 i1 1[ I I i Ii 1f 1 1 | 1 i1 1i i i i Ii [ [Worker j1 [ |Health S |25 7 84. 1 i 1 11 17 HAR 1 r 1T [22.02.23 Chloe 11 j1 _|1 [st Fons | 17.06.48 T 03.04,83 60 1 j |Safety Agent] j r 111 J________________________ i 11 1 34 28 [03.04.03 Yes [High - |Autoclave [other sectors |Retired l I i Chime | I I i i lI |23 yrs |cieaner |of St Fotls [01.01.79 l i i (Formerly | i ] i ! I i | |1940-1971 | Factory 1971- |j C Contassot I ! i RP) 1 i I i 1 II ll [1978 flatter of i 1i II 1 i 1 li 11 (5 10 1983 1 1i 1! l i 1 1l 11 1 1 1i 11 I t 1 iI !1 1 1 1i 1^- i I i 1 I! I1 1 l 11 18 |r 1i 11 I T T1i i -------------------- 1----------------1i------------------- i [14.07.42 1 Solvay |Tavaux | 09.09.63 21.03.04 ] i 1 42 1 I 21 11 i i1 21 |27.12.84 11 11 i1 21.03.84 [High-12 yrs|Autoclave l J________________________ 1 [09.03.84 i I1 !] i i 1 II [Lov - 9 yrs|Cleaner [Right i i1 11 i i 1 Ii ii [HepaUcccny i l1 1l i ! 1 II ii [05.05.B4- i !! ]I i i 1 lI Ii l | 24.09. S4 i 11 1' I [ i 1 Ii i 11 1I i 1 1 ii II ii [chemotherapy [for lung- i 1I 1I t 1 1 ti it [metastasis : i 11 iI i 1 ! lI ii |partial i 11 1I i 1 ! I[ i ii [remission. i t1 1t i 1 1 Ii it [08.84 - liver i t1 1I i ! 1 li ii [recurrence. i 11 1i i 1 1 Ii ii |10.84 - lung: i 11 1i i 1 1 li ii |evolut tori of i! j____________ j 1 1! i 1 1 j _L _L . It j j___________ [i jt | ( he cl i snase Page 9 FRANCE Sheet S E.IVKR Anqiosarccjnu Cases - (Review Date: I Ian 1990} t Ii ______1 12 1i1 _____________ 11 ii COUNTRY MID | NAME OR | DATE OF REFERENCE INITIALS | BIRTH NO l i l i i I 4 COMPANY FRANCE 19 MAZ 15.12. .12 Atocbem Bfi20 02.03.23 Atocbem i-------------------- -- -- ! i T------------------ -- -- I 1 iI I I f l [I I1 1 [5|6 |7 i6 1 ^ ! io 1 11 1 12 1 13 j 14 i t5 ! 1! 1 1 It 1i ______ _________ _______ ii 1 i 11 1i i ii 11 | | FIRSTVC| DATE OF | AGE AT | YEARS OF | YEARS OF | DATE OF | HISTOLOGICAL | ESTIMATED | | TO| FACTORY [ EXPOSURE 1 DIAGNOSIS | DIAGNOSIS | EXPOSURE | EXPOSURE | DEATH CONFIRMATION | EXPOSURE | OCCUPATION | LEVEL1 1 | DIAGNOSIS 1 t |1 | OTHER CAREER HIGHLIGHTS OTHER cowrorrs i1 1 f 1 1 11 11 1i {t 11 | 1 1--------------------------- 1 1i 11 l1 11 Myocardial 11 1[ t Autoclave Jinfarction 1 1I flrignnud 07.04.99 20.10.84 ! `>J 75 75 06.11.85 Yes High operator and| cleaner 1980.Coronary bypass 198L l [1 Letter from [ Dr Contassot 1 1 [ 5.4.86 11 1 ! Portal jBrignoud 1951 27.12.35 63 34 22 26.12.85 | Yes High Autoclave !Jn other parts|fibrosis from I operator and[of factory 26.04.74. The I cleaner since 1946 illness was I . diagnosed as I ' presumably I work related l on 20.04.74. l Letter frcm i Dr Contassot 1 05.04.86 21 Pa 01*10.40 RP SEP 1959 03.06.36 45 jflontluconj ,I I I I i 1 27 4 28.06.86 Yes High Autocleaner Maintenance 4 years worker Hepatic test .May 84 normal [Hepatic test [May 86 showed |abnormalities. Letter from Dr Barrat 18,07.86. |22 AL lj.oa.28 Atochem St Allban 01.09.58 l I I I ______ ______1_______ 1 f j 194423 DO 07.02.27 Atochem St Foais I i I I . J -- . ... . ______ [__ 05.11.37 1988 59 29 26 08.09.88 Yes High 12 years letters from 1958-70 Autoclave [worker. Dr Contassot, j Atochen |2.12.S7. IbOv 114 years in |29 7 88, | 1970-84 Control Room 1 24.U1.89 4463 28 21.09.89 Yes High Autoclave aParti 1 &|cieaner iHepatectcmy, Apr Mu pvc |88, Chemotherapy i [ ion fran[production Informat l | )<jh* Jllr J C I'onl ljswoI ________ il 1 J _________ _______ _______ i AI.kJmh, _________L 1'IHH/H') GENC 008268 T r*Kjwj fO I'lattce Sheet 6 LIVER Angina mind tos - (Review IMvi [ Jjimu.it y I'W) ---------------------- n-- ------------------ 1-- i -I ------------------------- 1 ---------------- 1------------------ ---------------------- 1 l1 5 COUNTRY AND NAME OB | DATE OF 1 REFERENCE imnusl BIRTH COMPANY | FACTORY NO 1 1 6 FIRST VC EXPOSURE 7 8 9 ID YEARS OF DATE OF AGE AT EXPOSURE YEARS OF DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS 11 DATE OF DEATH 12 13 14 HISTOLOGICAL ESTIMATED CONFIRMATION EXPOSURE OCCUPATION LEVEL 15 OTHER CAREER HIGHLIGHTS 16 OTHER COtENTS 24 HA 08.12.26 Atoehen Brignotid 1943 1968 62 45 35 01.12.88 Yes High PVC Product on Liver transplant (by 1988. ' - 2 years Information from Dr J C Contassot, HCV Detectit>0 - 3 years Atochen, 19B8/89 PVC Product on maintenance - 30 years ____________ _______ 1 -- 25 BB 02.03.30 Solway Tavaux 1962 1988 58 26 23 07.05.88 Yes 11 years} Polycleaner Pr inary Liver Tuaour Metastases High) - 5 years lung, brain, bone, spleen, Polyflooc kidney. - 6 years 12 years Control Root Information fren Dr H Lagast, Lew i - 12 years Solvay, November 1988 26 hg 29.11.40 Solway Tavaux 16.04.63 25.10.88 48 25 15 02.11.88 Yes High Autoclave 12 years Cleaner Low for 15 3 years years Died by haeaorragic rupture of the tinour. No surgery. Letter from Dr H Lagast, Solvay, 28.4.89. 27 RC 1929 Atochen St Pods 1954 1988 59 34 30 00.01.89 Yes 1954-74 Autoclave High Cleaner and ' 1974-84 all PVC Low production jobs Notified by Dr Contassot, Atocben, December 1989 28 j JG 1926 Atocbem St Foes 1942 11 1 11 11 i : 1989 63 47 20 Alive Yes 20 years IQ years High monomer analysis (labs) 10 years production PVC Notified by Dr Contassot, Atocben, Deceober 1989 1 _____ 1 ; Page 1 f GERMANY Sheet 1 COUNTRY AND REFERENCE NO HAKE OR INITIALS DATE OF BIRTH GERMANY 01 02 00.00.30 04 00.00.30 LIVER Angiosarcoma Cases - (Review Date: l Jan 1990) 13 FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL I ft OTHER CAREER J j HIGHLIGHTS | OTHER COftENTS 01.10.56 14.10.57 25.09.70 12 12 25-01.69 Yes (NIOSH) n u 14.12.71 Yes (NIOSH) Polyworker Polyworker 09.06.52 00.03.73 43 16.04.57 26.11.74 44 10.10.73 Yes (NIOSH) 25.11.74 Yes (NIOSH) FillLog pesticide aerosol cans with VC [Reported under [non poljaer|isation [workers in 1NIOSH list of j 31.3.77. 200-500 ppo Polymarker & 1956 was mt high tetqnrarr autocleaner during 1 yr autocleaner :or 1 yr autocleaner |This of course (is strictly [correct. [however I [wonder [whether this |oan had high [exposure to jVCH in his |can filling [operation? H------------------ l [Clinical [details in [paper by |Coke1 et ai [Virchows Arch [A Path 1976 j 372 p 195-203 I Page 'I'' GERMANY Sheet 2 3,1 VER Angiosarcoma Cases - (Review Date: 1 Jan 1990) 1 i 2 i3i _________ L 1 1L 11 COUNTRY AND | NAME OR | DATE OF | jREFERENCE INITIALS \ BIRTH f NO | 11 GERMANY L 1 1 1L 11 11 1 I1 05 f I (NIOSH gives| |00.00.36 1 it 11 as Case 06) | 11 l 11 I 11 1 11 I 11 ! 11 1 11 1 11 1 11 1 11 1 11 1 11 1 1! 1 11 1 -------------- 1_ 1 06 | 11 jt L1 |[00.00.32 I I[ (NIOSH gives) ]as Case 05) L 07 | Ii 1 l 1i|L |00.00.26 I 1 II I Il 1 Ii 1 li 1 lI 1 II 1 lI 1 II 1 1l -------------- 11 ---------- 1i--------- 11- 06 | |[00.00.17 I lI I II I1 l l r 4 _ t L 5 1 1 l 16 i ? 1 1 e 1i 1 [ \ | FIRST VC DATE OF | AGE AT COMPANY 1 FACTORY | EXPOSURE DIAGNOSIS | DIAGNOSIS 1[ _L i l1 [1 1 J 1 [ j1 1 n11 1 | 02.04.60 10.12.73 1 M 1l 1 9 YEARS OF f1 [ 10 1 11 r1 11 YEARS OF | DATE OF EXPOSURE TO EXPOSURE | DEATH DIAGNOSIS f i i 13 t----------------------- r 12 1 14 1 11 i i-----------------------r HISTOLOGICAL ESTIMATED | [ 15 OTHER ! 1 16 l n----------------------------] OTHER CONFIRMATION EXPOSURE | OCCUPATION | CAREER f C0MENTS LEVEL 1 1 HIGHLIGHTS 1 1 1 _|---------------- n------------------------r 11 [Confirmed 13 05 jl6.12.74 Yes (NIOSH) 1 |BG Chenle Jsajs E [ J 1 ]Reported under jnon-polymer- [l 1 f"chemistry J |isatioo 1I 1 jlaboratorian| |workers in 1I 1I Il 1 1 1 |in the |Techno|logical | | | [NIOSH list of j31.3.77 and j1.78. I donrt 1l 1 [Research | jthink this is 1l 1 [Departnert" | |a correct 11 1 [(NIOSH says | jclassification il [ [assistant [ |by NIOSH. The 1l 1 [factory | |nan may have 11 1 | chemist | [been involved 1l 1 |which maj be| | in VC71 11 1 | wrong [ jpolymerisation 1I 1 |translation}] jin pilot plant 1l ! [i 1I 11 11 [ r1 -- Ti II --i1------------- Ir |7 1 7 16.12.62 00.00.75 1 *3 13 12 J09.01.75 Yes - ||PVC Manu- 1l i I jfacture | YI i |Shift Leader! 11 1 11 11 \1------------ 1 a a | '1 15.04.S4 12.11.75 49 21 Tt---------- T 21 jl3.ll.75 Yes II -- i1------------- Ir- | |PVC Manu- 1I (NIOSH | |facture and 1I says 12} |all work | 1I ||incl auto- 1i 1I 1I [ [[cleaning 112 KS j |1(1954-66) 1I | |Foreman Tech 1I j1_ 1 i 1i 1 |A 4 19.07.54 06.04.75 58 20 11 11 11 1 J 1 ________ _________ 1 r |20 25.12.75 8 ||Dev yrs 1(1967-1975) j --t1------------- 1h| ?Yes > iPoljnorker ' 1( 1t 11 1 I 1 1 ________ 11 1J_______________ ___ |or in main |plant. H---------------- 1 1 1 1 -\1---------------- 1 1 i 1 1 1 1 1 -tj1---------------- 1 J 1 1 j_ _ _ _ _ _ _ _ _ _ 1 GERMANY Sheet 3 COUNTRY AND REFERENCE NO HAKE OR INITIALS DATE OF BIRTH GERMANY 09 00.00.34 10 {NIQSH gives as Case 11) 00.00.36 11 (NIQSH gives as Case 10) 00,00.29 00.00.38 LIVER Angiosarcoma Cases - (Review Date: I .Jan 1990) FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YFJRS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED FJtPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMOTS 20.02.61 16.06.76 01.01.61 00.01.77 40 10.10.55 20.06.77 00.00.61 00.10,77 24,03.78 10 22 28.06.77 High peaks 12 yrs poly worker incl 17* auto clave cleaning Control roco 1 jr High peaks 10 yrs polyworker incl 17* auto clave cleaning High 3 yrs auto clave cleaner 19 yrs filter operator PVC Manu facture Autoclave worker for 6 yrs 10/78 Coafirned Average exposure first 9 its 150 ppm, occ 1000 pip. Next 3 yrs av, 75 ppn. Last. yr av 35 ppnt Average exposure first 9 yrs 150 ppm, occ 1000 ppra. Last yr av 75 ppm. CWH letter of 21.04.7B Frige 1 ^ GERMAN? LIVER Angiosarcoma Cases - (Review Dale: I Jan ITO) Sheet 4 1 COUNTRY AND 1 2 31 -------------------- 1 ------------------ l r NAME OR DATE OF | REFERENCE INITIALS BDtTH | NO 4 COMPANY i5 t T------------------ | FACTORY 6 FIRST VC EXPOSURE -- ---------------------- 1 78 9 DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS 13 00.00.14 [ 7 1 7 00.00.60 08.04.78 63 18 --[ 1 -- (14) ( 1 1^ 15 (NIOSH gives this as Case 13) 00.1X1.29 j a 1 a 19.10.53 09.10.78 49 25 ! Iu 10 j1____________ | YEARS OF ( DATE OF EXPOSURE j DEATH 12 HISTOLOGICAL CONFIRMATION 14 (19.05.78 Yes Not an Angiosarcoma In his letter of 21 12 81, Mr Frledel said this was a "Plattenepithelkarzinon Der Speiserohre" l {(a carcinoma of the oesophagus) not attributable to VCH & not recognised as an iodustrial disease 25 [23.10.78 Yes I 1---------------------- i 13 1 14 n 15 16 J---------------------11 ESTIMATED 1 j OTHER j-- OTHER EXPOSURE | OCCUPATION i CAREER COMMENTS LEVEL 1 i HIGHLIGHTS j----------------------j_ 11 li j F W Best 1i letter of 1i |30th June 1980 !i !i (enclosing data from 1i |Kr H P Frledel 1i j1 41_ 1 11 i1 11 11 11 11 11 11 I1 [of BG Cheaie J---------------------- F V Best letter of 30th June I960 enclosing data from K P Friedel of | BG Cbeaiie [withdrawing J this case 1( !1 11 11 11 11 11 11 j[ 4_ I 7 |Autoclave 1 |cleaner and 1 j [Angiosarcoma (confirmed [worker. l |09/79. Some [Drier 1 detail of this [operator. i [Later shift 1 |& also cases |9, 13, 15, 16 |leader I i 1 & 17 given in NRW Report for 1978 GENC 008273 k'.jifi1 | i <,i,mmany GU'et 6 f. L y! H Afii11 nsar rr*na CdM^s - (Review halt*: S Jan 3 OK)) 1 ]1 ---------------------- 11 _ fi i1 i 11 COUNTRY AN1C f NAME OR | DATE OK | i i 1 , 1 (, 1 | t |1- 1 T 1 f | f KJkMT vr | mate ok fl Afik AT 19 | YEARS OK i ifi 1----------------1 E1 1 1 | YEARS OK 1 iA'E'K OK 12 IN STOI.OG 1 CM, --1 n1 KS'NMATKE 14 RfTkRKNCE | INITIAL | HIBTH [ aw*NV [ KAiTOKY i HtE'i til JR K | DIAGNOSIS 1 DIAGNOSES | kXPOMJRE TO | hXNOSIJRE NJ-.A'm CONFIRMATION KXKOSIJHL | OCCUPATION H(J | ---------------------- h1 16 | l l l l 11 !1 1 1 11 E 1---------------- 1--------------------1- | T i I lw.00.23 [ 4 J 4 1 io.m.55 | 07,08,73 1[ 1i |(Leibach 1 11 1i |susfMfcted 1 11 Ii | ASL at 1 11 !i |Feb 1976 1 86 j DIAGNOSIS E r \ i1 I t ! [ 30 LEVEL 07.0fl.7B Yes ASL and Hepatocellular Carcinoma High JAutoclave |worker tit] ]1964. |Leader and | roaster l 11 ii |laparotomy)| I l 11 !i l 1 1 l 11 [i l 1 i l f! fi l 1 ! l [i 1i l ] [ 1 1I li l 1 [ l 1[ [i 1 1 1 ! 1t l! l 1 i 1 11 I1 l 1 1 1 11 i1 l 1 1 | 11 1| I 1 I 1 | 17 | (KIOSH gives] as Case 1$) [ 1----------------i--------------------r |00.00.37 l 4 | 4 E 1 (H .11.61 | 14.08.78 41 i i& II i[ 1 [ l1 ii 1 1 1 1n i i 28.08.79 Yes High |Autoclave |worker I i 1! i i1 1[ 1[ 1 1 1 I i i i I i ] I i i I i i I ! 1 1 1 j 18 | 1 1 1 19 j i t 1 ______________ L 11 11 11 11 i1 11 11 I1 11 11 11 11 11 11 1[ 1! (ffluM.n | 1 1 I 1 1 1 1 1 1 1 1 1 1 I 1 1 | IJ 11 1 1 (oo.oo.76 j E 11 4| ii i 1! 1 E1 i J________ 1__________ L i1 1! ! I 1I i 11 1 t[ 1 11 1 11 ! i1 1 11 ! 11 1 ii 1 11 1 11 1 i1 1 11 1 11 1 jj | 6 00.00.55 1 25.12.79 66 1 1 1 lb. to.vt | (MMia.79 1 1 1 54 11 [ 11 [ f J__________ j 1M i i i i i i i i i i i i i i i j 1 j i 1 76 1 i 1 E i i ! J_______________ _L 71 ia 25.12.79 Yes 22.07.80 Yus letdstdsincj ASL L________ L L j |Autoclave (Worker J High |Anloclavo (Worker j 16 either "1------------------------f io _J________________ 1 | (/jwr CAREER ] OJMIENTS HIGHLIGHTS ! 1 1 jAngiosarcoma | confirmed,, lull details |of illness (since March |1973 given in |KRW Mod Insp |Rep for 1978. |pifferert |details given | in "VC (Associated (Disease1' by jLelbach and |Marsteller (198U p7!. 1 Ho J Angiosarccna (confirmed. |Annual report |of tire North (Rhine [Westphalia [Medical |Inspectorate (for 1978 |pages 347-377 (gives full (details. Vinyl [chloride [disease (diagnosed |07-02-73. jOesophageal ]varices. | Radioing ir:al ly |confirmed aero (osteolysis. | 1 /f J Ur ftesclw [letter of |n-(M-82 tt, JlJr W 6 K Adrims J l'^' I GERMANY I.WEK Ajiijiusrin t.t.s'nj: ( Review iJcile: j fan 199U) Sheet 6 2 1 1 I1 11 ------------------ 1 4 1 (' J 1 1 -1 j1-------------------- 1 OjUNTRY and REFERENCE NAME OR INITIALS DATE OF | MRST vr 1 OATH Of BIRTH |COMPANY FACTORY EXPOSURE 1 DIAGNOSIS NO | 1| 20 | 1 ------------------ 1j 00.00.IS I 4 11 Il 1 14.07.6) | 00-04.8U Il 1 ll l I[ 1 1 1 ! 21 j 1 1 ) 0U.0Q.13 | 4 i i1 4 01.01.62 | 00.09.19 1 1 1 1 1 1 22 ( i 1 l 1 1 1 00.CIO.21 I 4 [pronounced (clinical [liver (symptoms) t { 4 15.10.61 | 28.0B.80 il 1 i I 11 8 10 1 31 12 15 | 14 15 | L. I 1 l| IllS'PU 1 AGE AT YEARS Of DIAGNOSIS | EXPOSURE TO YEARS OK EXPOSURE DATE Of DEATH EOKJCAI. F.STI HATED | CONFIRM- EXPOSURE | OCCUPATION OTHER CAREER DIAGNOSIS ATI0N LEVEL | !| HIGHLIGHTS 66 19 n 19*10.80 (Yes High |Autoctave |Maemangio |Worker Endothelioma | of liver with | jhetdstases | 1____ ______111 66 (8 13 19.06.80 Yes Hiyh |Autoclave (Baemangio (Worker and | Ended belicnia {worked in (of liver with (drying shop | 69 19 , 11 06.12.0! Metastases _1___ ------------------ 1 Yes -_ High | 11 ------------------------- |Autoclave Cbargehand, Hetastasing [Worker subsequently ASL Foreman l 16 CT1ILR CCWiEHTS Dr Besche letter of 13-04-82 In Dr W V F Adams Dr Besche letter of 13-04-82 to Dr W G F Adams Or Besche letter of 13-04-82 to PrWGF Adams 0 2123 00. DO. 27 ( a 1955 | 26.03.79 5? 24 29.09.81 Yes High (Chemistry [(>300 ppm} |Worker UO.OO.28 [ ------------ 1------------ l%9 l U. 10,82 I I 12 l28.05.8J j yes j High (Autoclave j | |(>300 ppm) [Cleaner Primary hepalocetlar [carcinoma; tprol tferaUon of the jsimJsiodaj cells with {sinusoidal ectasia. (Friedel letter 23*12.86. jprof F.der (Munich) (letter 22.CS8.83, {Friedel letter 19.04.85. 25 (26) [00.00.23 I + 1(10.00.28 I 4 | 19B5 j IB.01.S3 13 14.01.83 | Yes High Jpolyclave (Worker and (Autoclave +I |Cleaner [Deleted on advice of Ur Tenkhcff December 1989: |Alcoholic Cirrhosis, not VCH associated. + IB {02.03.84 j Yes | (Sigh |Autoclave ] j| |rleaner till 1 II I(0(2 _____ I________I_______ I________ I__________ |Prof Selmair (Munich) | letter 22.08.83. (Friedel letter 19.04.86 {L* t bach. {Friedel letter jl9.U4.85 J___________________ GENC 008275 Page* GERMANY Sheet 7 1 ---- 34 I COUNTRY AND | NAME OR RFFERFJTCE | INITIALS MO I DATE OF FIRST VC BIRTH COHPAHYj FACTORY EXPOSURE 21.11.23 7 7 01.10.60 29 30 3> I 32 | 00.00.22 2 2 1962 00.00.1/ 00.00.23 4 4 1951 -------------- j a 8 1953 r" 00,00.30 8 "(55 LIVER cent) Ouses { Rpvipv iJate: 1 Jon 199(1) 7 DATE OF DIAGNOSIS ii. os.as 15.02.83 07.01.80 30.06.85 00.04.85 a AGE AT 1 9 YEARS OF 1T------------------- Im 11 [ U 1 17 MSTO -- 1n 1______________ 11____M____ 1 | YEARS OF DATE OF LOGICAL | ESTTHATED DIAGNOSIS 61 EXPOSURE TO EXPOSURE DIAGNOSIS 25 1 11 1 25 DEATH 25.08.85 CONFIRM- l EXPOSURE OCCUPATTON AXIOM Yes | LEVEL 1J______________ | Nigh Process l worker l 1974-84 11 l i 01.10.60 - 31.03.84 I PVC l production. I agitator I area l j .l 2161 t13 15.02.84 Yes High Chemistry 11 11 J1 worker 62 29 1 25 25.05.83 Yes High Polyvorker 1 Shift leader 1 1____________ 1 2061 32 31.01.86 j Yes | High Autoclave cleaner ____________ OTHER CAREER HIGHLIGHTS OTHER COMMENTS jAnnuaI YCH screening |24.04.SS: no complaint, [no abnormality detected. |1970 two-thirds jgastrectomy for ulcers. |1971 Coronary thrombosis ]l9S3 Femoral | incantation |1984 Pulmonary embolism land pleuropneumonia. |landers letters 18.09.85 land 04.02.87. Haemangiosarkcraa. Friedel letter 23.12.86. | Haenang iosarkena. iFriedel letter 23.12.86. |Baemangiosarkoma. (Friedel letters 23.12.86, 115.11.89 & Fendel 16.2.89, 55 30 21 15.07.86 | Yes High Polyworker Autoclave cleaner Haemangiosarkoma. Also Developed Cholanqiosarcoma. Friedel letters 23.12,86, 15.11.89 and Fendel 36.2.89. 2100.00.17 B a 1953 19.08.83 67 30 25.03.85 Ves High Autoclave Cleaner, Chemistry Worker Letter from Dr Friedel 15.11.89 00.00.34 4 4 1956 13.05-85 51 29 16 17.09.85 Yes High Shift Leader 1%800.00.24 4 4 18.2.73 49 5 4 16,10.84 Yes High Autoclave Cleaner Letter frera Dr Friedel 15.11.89 1975 disease of liver parenchyma; at last l-etter from Dr Friedel 15.11.89 GNC 008276 GERHAKY Sheet 8 UVKH Amjujj.nr < -- 2 1 4 > f' ' -------------------- [ ! ii ll i i COUNTRY AND REFERENCE HO name or | date of INITIALS | BIRTH 1 | | first ur | nm of amml factory! exposure 1 diagnosis 11 1 B AGE AT DIAGNOSIS Oases ( Hovivv ! Ian 1990) ------ 10 ___n___ ______ _______ M ________ IS -- YEARS of EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF UFATit iilii'm !.i*;h:ai CONFIRM ATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER H [(II (LIGHTS 16 tflUKR C0HHF.NTS 36 00*00.13 4 4 1953 19.01.76 b7 23 ?3 34.02.86 Yes High Autoclave Worker Letter from l)r Friede! 15.ll.B9 and information from Dr Tenkhoff Dec 89 3/ 00.00.2S 4 4 1969 09.08.3b 59 16 6 0b.09.36 Yes Laboratory Letter from Dr Friede! Assistant Lb. 11,89 33 00.00.22 4 4 1964 I6.0b.8fl 66 34 S9 16,09.86 Yes High Shift leader Letter from Dr Fnedel at the t5.ll.89 autoclaves^ later on at t.he tumbler 39 00.00.42 4 4 1%8 00.10.96 44 13 5 03.]1.86 Yes High Autoclave Cleaner Pension from 1974-84 80% later on 100%. Letter frcm Dr Friede! IS.11.89 and information from Dr Tenkboff l)ec 89 GNC 009277 Page 19 ITALY Sheet 1 i 234 1-------------------- ------------------ 1---------------------COIHTR? AH) | JUKE OR DATE OF | 5 REFERENCE NO INITIALS BIRTH CCKPAKY l 1 FACTORY 01 (On N1QSK supplemen tar? list) LG 15.06.34 PANSAG 1 1 1 1 1 1 1 Kira Venice 02 SE 13.11.29 Montedison Porto I Nargbera 1 03 VG 14.03.20 Sclvay I I Ferrara 6 FIRST VC EXPOSURE 00.00.65 00.00.57 00.01.53 LIVER Angiosarcoma Coses - (Review Hate: 3 Jan 1990) 7 DATE OF DIAGNOSIS 19-04.71 13-12.72 10.07.75 B AGE AT DIAGNOSIS 36 43 55 9 YEARS OF EXPOSURE TO DIAGNOSIS 06 15 22 i 10 n| 12 13 14 i -- 15 16 YEARS OF EXPOSURE DATE OF HISTOLOGICAL ESTIMATED DEATH CONFIRMATION EIPOSURE f OCCUPATION 1 11 LEVEL OTHER CAREER HIGHLIGHTS OTHER COMMENTS 03 16.04.71 ?Yes l l I I l ! i 06 27.12.72 Yes 1 i1 PVC Bag extruder Polyworker Primary ttnour may have been pericardium. Not homogeneous with other cases. A A*** * *4 21 10.07.75 Yes l I High Autocleaoer 1972-5 did 9 yrs {1953- a variety of f 61) Autoclave jobs operator including 12 yrs (1961 - PVC packing. 72) ** 04 FB 20.07.37 ANIC l Ravenna 00.04.59 00.01.81 f I l l l I ! 1 1 l 1 1 l 1 -------------------- 1 05 G Danesin 15.03.37 PANSAC Kira 00.00.67 07.03.83 i Venice I 1 1 1 43 46 21 21 30.03.91 Yes 12 jrs - 1 rr - Never cleaned I Very High Hooomer autoclaves. l (operator See paper by A* I 5 ITS - CHIAPPINO et Kon-aooker. I Medium j 20 yrs - al Med lavoro Coasumed I Autoclave Vol 6 (1992) little * l 4 Yrs - operator & pp 555-563 alcohol. No I Lou other duties AOL. I |in suspens- l ion polymer- i |Isatioa. 1 11 l (Area Foreman i |io sane Dept 1 |since 1975. 11______________ 1________________1 1r 16 8 06.04.83 Yes jNedlm-? |Bag extruder | |High |1967-1975 S Paglialunga telex of 1 |Ca*rciaI 2 Aug 1983 1 joept 1976- 1 . i1 |1983 1 * See Kaltoni Bed di Lavoro 65 p445, 1974. Further details in letter from Dr Montesano of IARC on April 1st 1992. ** Also see Kaltoni and Anndtnella in Acta Oncolotjica Vol 1 39BQ p.xjes 15 - 49, GENC 008278 Page 20 ITALY Sheet 2 LTVKK Angiosarcoma Cases - (Review Date: 1 Jan 1990) 1 COUNTRY JLHD REFERENCE NO 06 07 2 3l 4 i 1 5 |6 j i I |7| 8 11 11 1 ~T~ 9 i 10 1 11 1 ( YEARS OF 1 12 13 [ H 1 l 1 1 15 1 E 1 16 HAKE OR INITIALS DATE OF | |FIRST VC BTRTH COMPANY FACTORY |EXPOSURE i1 i__________________________ 1 1 1 DATE OF |AGE AT EXPOSURE YEARS OF DATE OF [HISTOLOGICAL ESTIMATEDj |OTHER DIAGNOSIS!DIAGNOSIS TO EXPOSURE DEATH CONTI RHiTI OH EXPOSURE j OCCUPATION jCAREER 1 DIAGNOSIS 1 ___ . ... t 1 1 LEVEL | Ji1 1 [highlights] I i OTHER CdflENTS GZ 21.06.36 Montedison Porto |01.10.60 06.12.as 1 49 25 25 13.02.86 Yes High PVC 1 Letters from Dr Chiozzini, Venice, I harghera,| i I 1960-71 manufacture! 22.09.87 and 11.01.88 ] Venice | I I Medim 11 years as| I iI i 1971-74 Autoclave | ! iI t Lew cleaner | 1 iI l 1975-85 1960-71. | 1 iI [ 14 jears in| 1 ii ! Control | _______ 1 1 1 iI 1 i 1I 1, ! i l_______________ i l Room 1971-85 I t | | j 1 1 AP 09,02.25 Moplefan Tern! | 1950 21.01.86 | 60 28 22 05.04.86 | Yes 1950-74 Maintained | Information from La nedicina del I I1 i High VC Machinery lavoro, Italy, Vol 79 No.l i i1 i {not | Jan-Feb 88, and Dr Benetta, I I1 i operating [ EnlChen. I i1 [ or cleaning! i i1 i autoclaves)| i i1 i 1974-80 VC levels ! i [i i Neditn reduced frcn l ! 1973/74 [ 1f II GENC 008279 Page 2. I JAPAN LIVER Angiosarcoma Cases - (Review Date: 1 Jan 1990) 15 COUNTRY AMD REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FIRST VC EXPOSURE CATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS Of EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED j EXPOSURE j OCCUPATION LEVEL l -f OTHER CAREER HIGHLIGHTS OTHER CCWENTS 01 Taaoji 01-08.22 Mitsui Nagoya 00,04.53 24-10.75 53 72 13 24.10.75 Mori Toatsu PVC Assoc |13 yrs auto- says not {clave known. Jcleaner Japan Times \ 1964 * |assigned to indicated {different on 25.10.75|work since exposures (had ill 'often at {health 3000 pfn up] to 1974 | ---------------------- 1----------------------- Japan Times 25.10.75 & Japanese PVC Assoc letters of 31.03.78 & 30.11-87 02 02.08.39 Kanegafuchi 00.11.58 10.08.76 Chemical 13 10.08.76 Not known |In polymerjisatioo work (including {autoclave |cleaning Japanese PVC Association letters of 31.03.78 S 30.11.87 03 01.09.30 Mitsui Nagoya 00.07,65 26.06.85 54 20 Toatsu 14.09.85 High i |5 years |Autoclave ]cleaner I Letter from Dr Nakamura, Japanese PVC Association 30.11.87 _1_ NORWAY LIVER Angiosarcoma Cases - (Review Dale: 1 .Ian 1990) COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST YC EXPOSURE DATE Of DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS 01 AH 23.12.15 Norsk Hydro Heroya 00.03.50 21.12.71 22 04.01.72 Yes High Foreman & | |Confirmed by Autoclave ( |Dr Thiis- supervisor \ jEvenseo of NR. I (At APME Ntg of [ |9 June 1978 i [Hr P Rangoes I |stated that AH I |had been a I |member of a I |start-up team. I |VCH & PVC were l [made in same I jbuilding. The I |VQt was made i |frora acetylene Page ."_3 SPAIN LIVER Angiosarcoma Cases - (Review Dale: 1 Jan 1990) COUNTRY AND REFERENCE NO NAHE OR INITIALS DATE OF BIRTH COMPANY -- ---- -- 8 . till | FIRST VC | DATE OF | AGE AT | YEARS OF FACTORY j EXPOSURE j DIAGNOSIS | DIAGNOSIS | EXPOSURE TO DIAGWOSIS 10 ii 12 u H 15 ------ --------_________________ _______________ I _______________________ -- -- 1 YEARS OF | HATE OR HISTOLOGICAL ESTIMATED OTHER EXPOSURE DEATH tMfflRHATIOH EXPOSURE OCCUPATION CAREER LEVEL HIGHLIGHTS 16 OTHER COMMENTS 26.03.40 Hispavic Torrelavega 01.02.64 10.11.89 49 25 13 09.11.69 Yes High Autoclave From 1.1.78 Cause of death: 12 years Operator production of multiple 12 years. hydrogen cerebral peroxide haemorrhages. Medina Latex No metastasis. 1 year 1 year Letter from Dr Lagast, Solvay, 04.01.90. GENC 008282 :h LIVER Angiosarcoma Cases - (Review Date: 1 Jan 1990) I 13 IS COUNTRY AND REFERENCE NO KANE OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS ( j OTHER COMMENTS 01 23.06.27 Kemanord Sundsvall 14.08.51 20.10.70 43 02 77.11.11 Keraanord Sundsvall 00.01.45 00.00.72* 27 20.10.70 16.08.72 10.06.10 Keoanord Sundsvall 00.05.47 10.03.76 29 04 116.11.14 Kemaoord |Sundsvall| 00,00.46 | 12.05.77 62 19.03.76 12.05.77 05 12.03.19 I Kemanord ISundsvallI H.05.64 I 22.11.80 16 16 22.11.80 High Palyvorker jvof | production High |Polyworfcer High j1946-1958 j |polymer- J (isatlon j |worker (12 | jjrs) S 19S8-I (1977 foreman| 1(19 yrs) 1 1i 11 11 11 1i l1 High 6 Years Low 10 Years 1 |1964-1970 |centrifuge (operator 11970-1980 |drier (operator 1 j \ | | + (Mr Sjoelin's ] letter of 128 March 1978 (confirms BL (was a monomer |worker who was (heavily (exposed, (probably even |more so than ja normal |reactor |cleaner + I jin first 12 |yrs of | employment had [been heavily |exposed. In |l974, liver |abnormality [and necrosis |diagnosed. [Data confirmed [in Dr D Byren (letter 18.8.77 |to CEF1C __________ 1_________________ 1 [Letter of [2nd Nov 1981 [from fOr David byrun * In his letter of 1st April 1982,, Dr Nonlesana of iARC says Sweden's National board ol OS Health gives 20-02-/0 as dale of diagnosis for Case 01 and 15-05-72 for Case 02. GENC 003283 Pug< 11 COUJTTRY AND [ UK - Sheet ? ? TT"I NAME OR 1 DATE OC | lotarctrca Cases - (N 1 Dale: t ,(<m E r3*J0) 4 1 ' r i 7~ a1 9 | 10 ii 1 | FIRST VC DATF. OF AGE AT YEARS OF | YEARS OF DATE OF REFERENCE \ INITIALS mj 1 1 us |rk BIRTH | COW ANY 1 ! r .50.03. M | HP j FACTORY J EXPOSURE i f |liarry I f 1 | 08.01.51 DIAGNOSIS 00 1U./9 DIAGNOSIS 6S FXPOSURE TO j EXPOSURE DIAGNOSIS 28 1 t 1 21 DEATH 19.11.79 i l ij ! i il 1 l il 1 ! i[ [ 1 il 1 1 i1 1 1 i1 1 1 i1 1 1 il 1 i il 1 1 iI 1 1 I1 i 1 [1 1 1 1 06 |GP 1931 1 1 1 | BP 1 1 n |Barry 1 1 1 | 1962 09,01,80 48/9 18 1 12 09.01.80 l I il 1 I II l I [! l [ i1 1 1 1 07 | RGB 1 1 1 26.01.20 | BP I i n jBarry 1 i 1 | 1963 00.00.80 60 17 j 8.2 13.06.80 1 i iI 1 [ ii 1 i !i j L j______ i j 08.05.24 BP | Barry 19.D9.50 27.ll.Bl 25.12.81 12 1 13 i H1STOLOG1CAI j ESTIMATED 1 M CONFIRMATION | EXPOSURE | (XWATIOII | I.KVKI. 1 11 t1 Yes J |1951-52 1 (Polycleaner l [IW.-5S 1 | Latex 1 11955-60 1 IPolyfioor 1 ll%0-64 1 | Poly l jchargehand 1 jl9M-70 1 |Charging 1 [operator t |1970-72 1 l |Drier 1 1 1 Yes 1 |operator 1 1 |7 yrs 1 [poJy Floor 1 1 |[>perator [ |rj yrs l jGreaser on 1 1 1 Yes 1 |Poly Floor 1 1 [Polycleaner l [1963-5 l JRecovery f |l%5-1971 j 15 OTHER 1 | CAREER | 111 GUI, [OUTS [ _l1 16 OTHER cowents (Further finformation |1969 from |Dr P M Smith |and Dr D fl J [Will lams 1 l l 1 l l 1 l 1 1 1 |Further |information 11989 frccn |Dr P fl Smith |and Dr D N J |Ui 11 tarns I 1 |Further inform(ation 1989 frcn |Dr P H Smith & |0r D N J William 1950-1958 500 ppn 1968-1974 200 ppm 1950-51 Autoclave |1938-1948 further [Motor Mechanic information operator [1948-1950 1989 from 1951-1957 [operator on Dr P fl Saith Cbargeman |Aoetylene and Dr 0 H J [autoclave [production WiIlians |building [Plant 1957-1974 1 (Shift l (supervisor l [autoclave ! |buiIdtng - 1 Never 1 cleaned 1 (autoclaves 1 [but i supervisor s[ | }ob entailed| entering 1 autoclave?; I [ 1 3 inspect 1 r him 1 1 GENC 008285 LIVER Angiosammw Cdses - (Revirw Hate: ] .Inn IWJ n I 14 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE j OCCUPATION LEVEL | OTHER CAREER HIGHLIGHTS f j J OTHER CCWIENTS 07.OS.25 BP Barr? 15.02,50 02.0J.83 58 33 24.02.83 Median | Polyworker 2 years on j Acrylonitrile f Resin Plant, j Also prior to | 1950. 4 years[ RAF j maintenance. f 3 years motor J car paintshop.| 2 fears in j Graving Dock. --1----------- --1-------------- H--------------H-------------- H------------------ 1----------------- 4- -4- -4----------------j-------------- +- l-------------------H------------------------ 1--------------------- 4--------------------------- 10 |gjt [04.04.47 j BP [Barry j 27.CH.66 | 01 06 84 [ 37 l ]8 i 4.7 llf,.as.81 Yes | High - 11 [Polycleaner |Heavy goods | Infonnat ion 1 ]I l1 1 I l I1 [months (5CK)| 1966-67. [vehicle driver [given in 1 1l l[ i I 1 l! |ppm). Low -|Spray-drier |until final | letter 1 l! [1 1 [ l I1 j18 months [bagger 1967-1 Hines. Jl8.06.84 from [ I1 l1 [ I [ t1 ! I1 1 l ! !1 11 1(50 ppm). |68. IdediLn - |Blow-down | | |Dr 0 N J [Williams 1 l1 [1 1 I 1 11 |2i months [stripper | I t1 i ! l1 l[ 11 [{TOO ppai) [operator j 1 1 !1 I1 ! Ii 11 1 f19*0-70. | [ 1 11 --1----------- --11--------------- -1 1 11 |glp l08.OS.28 J BP l1 1 [1 1 11 \ i 1 i (Barry ( 19.12.65 ( 02.06.85 1 57 19 1 i n f 16 1 1-- |C2.06.85 1i 1 l ------1------------------ -j--------------------- -----------------------H--------------------------- Yes (High |Polycleaner J [Letter of i il iI I l 1 1I J1965 -69 j1965-68. | J 04.06.85 i i[ ii I I 1 1i |Hed 69-79 (Service [ |Dr Paul Smith i tl ii I1 i fl i1 ! l 1 1I 1I (Low 79-02 (operator I |68-69. ( j [and letter of [04.06.85 i Il i1 1 l 1 [[ l [Pol? | [Dr D H D Evans i il i[ 1 I i i iI i1 1 I 1 1i 1i [ (Operator | l j 69-79. j |Oesophageal (haemorrhage i iI [1 1 I 1 1I i (Leading Band| (due to i [I ii I I I 1I I 179-82. | |oesophageal i II I1 ( I I 1i l1 1 [varices due to i il i1 1 I 1 1i I1 1 (Angiosarcoma i i[ --i----i-------------- j 12 jjT 11 (24.01.37 | ICI 11 1 1 l 1 J1 . j 11 1------------------ i-- 11 (Hillhouse| 16.09.57 | 03.06.85 1 48 1 28 11 r l1--------------- 1 2S |l)6.12.85 ![ 1 |of liver 4i --i--------------------1-----------------------1---------------------- --------------------------- Yes |Low 1957-59[Spare man, [ |letter 1 il I1 1 i i 11 (High 59-74 (bagging ( [26.06.85 1 I1 i1 1 i 1 1 1I (Low /4-85 [floor J [Dr F I Lee 1 i1 i1 f i 1 I1 [ 11957-59. j i l iI i1 1 i 1 l Il i1 1 i 1 11 11 i [Autoclave | i [operator i I 1 _j________ l t i j I1 1 i ji i j___ 1 r 1[ i1 | [' [1459-85 l l i i GENC 008286 PriCfO ' UK * Shofttl COUNTRY AND REFERENCE NO NAKE OR INITIALS DATE OF BIRTH 02.Q3.48 BP lb-06.4 BP 23-08.2 BP 25-05.2 14.01.31 LIVER Angiosarconn CrJ.sns - (Review ffcsle: ] January 1990) -----!--------- [------ FACTORY FIRST VC EXPOSURE YEARS OF DATE OF AGE AT EXPOSURE YEARS OF DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE OF DEATH 4- KISTO- || LOGICAL |ESTIMATED| CONFIRM-]EXPOSURE[ OCCUPATION ATI ON | LEVELj | (OTHER |CAREER j HIGHLIGhTTS OTHER COWENTS Barry i%a Jan 86 ferry 07.07.66 27.08.87 45 ferry 1956 66 32 Hillhouse 1963 1988 66 25 02.06.86 01.05.88 1 High fPolyeleaner |Hoved to Remained well, working i |1968-69 [Acrylonitrile actively, until Jan 1986 i (Central (Plant until [ [Depot |left BP 1983, 1 |1969-70 j High (Polyfloor |Hanager of IC S Jss Ltd aL I [1970-1971 ff |10 mcmths|po]ycJeaner |Cardiff Airport [1983-86 1 fetters from Dr PHD Evans, [High (1966-67 I Pathologist, Penarth, Wales |10 years [Polyfloor [ and Dr DHJ Williams, BP, Barry (constant J worker at t Dies I |Median | between 1 [but on ji%e-i9!i2 I (inter- J f Inittent | Ijobs j ] j H----------- I-------------------- |9 years (Poly cleaner & ) Information from | High i{5 years J Medium |2 years |Operator ) i_, ,, .Exposure [Blow Recovery) J Operator periods |Utility intermittent ) )rOM J Williams, BP, and Dr Paul Smith, Pathologist 1988. f Low + j Operator 12.J1.88 Yes Jt year ) (Packer j Low ) | |9 years) | | High ) [Autoclave j2 years) (Operator Low } Hepatic fibrosis 1974 Oesophageal varices Porta-caval shunt 1975 nfonnation from Dr B Bennett, CJ, and Dr F I fee, Blackpool ictoria Huspilal 1986. Ki1)house 08.04.63 26 17.09.89 1963-63 Packer Low 2 months 1963-74 ) High ) Autoclave (II years)) Operator 1974-88 j) 25 years Low |) (14 years)) __________ 1_____________ Information from Dr 8 Bennett ICI, and Dr F I Lee, Blackpool Victoria Hospital, 1989. GENC 008287 USA Sheet 1 UYER Angiosararoa Cases - (Review Date: ] ,lar 1990) UK system of dates DAY - MONTH - YEAR 1 1 n-------------- n------------------ i------------------ 1 1 12 13 1 1 |5 j6 | ; 1 8 j Xi 9 ] in i 11 l 12 n 1 14 f 15 -- _i J J 1 11 COUNTRY AND | HAKE OR [ DATE OK 1 _i j| T[ 1 1 1 1 I f1 1 | FIRST VC | DATE OF ! AGE AT j YEARS OF 1 YEARS OF | DATE OP | HISTOLOGICAL ESTIMATED j1------------------------! OTHER OTHER REFERENCE | INITIALS | BIRTH | CCHPANY | FACTORY j EXPOSURE | DIAGNOSIS t DIAGNOSIS | EXPOSURE TO 1 EXPOSURE | DEATH [ CONFIRMATION EXPOSORE [ OCCUPATION [ CAREER COtttENTS NO 1 I1 [I 1 1 | DIAGNOSIS i iI J J _| 1 11 j J| 11f l 1 i ii ii 1 1i I11 [ 1 ii LEVEL | HIGHLIGHTS 1 History given Rolling Stone I Ii 1l 1 i i !1 in Annals NY Art 01 [Earl | E/.10.23 | Eire [ixiuis- [ 09.12,43 [ 03.03.73 i 49 [ 24 i 21 [03,03.73 j Yes 1 Pol Cleaner ACAD SCIENCES (Ref 1 NY Scad |Parks i i | ville 1 I [ ( l1 ((Block Jana |Vol 329 (J979)|of Sc Sjnp [ [i Il l i i Il | 1974) p 53 jpage 190 in 1974 I 1i If 1 i i (I Paper by Also Block l ii I1 i i i ll B R. Coltine of Jana 1.7.74 f J 1 02 i 1 1. J I 1 (19.08.3J | BEG 1 i jLouis- 11 J1 11 | 15,11.55 | 00.05.70 37 1 M 11 1t \\ 13 j27.09.71 | 7es OSHA [Pot Cleaner P 53 Ref 1 i 1l | ville l l i i [(NIGSH | |(Cf Block) Also Block i 1l Il l i i [says | JAKA 1.7.74 ! 11 r 11 l \1 03 jEdward [25.05.15 | bre 11 i i |28.09.71)| fi i ll I [Louis- 1 1 i" | 28.11.45 | 19.12.73 58 j 28 T i---------------- r 28 [19.12.73 | Yes |pot Cleaner Louisville P 53 Ref 1 [Dinwiddle I i J ville I I i i (l |(Cf Block) Courier Also Block i Ii il ( i i II Journal 1 1 04 J [1 |I 11 [15.01.24 | BFG 11 1 11 i] 11 1 1 i tt T i-----------------r jLouis- [ 06.07.52 | 19.08,67 43 1 15 15 J07.01.68 I Yes ( 02-09-80 [Pot Cleaner Ref 1 1 1 1 OS 1 1f 11 11 |25.0K12 | BFG j ville 1 1 11 1 1\ t \ X X 11 1-----------------r [Louis- 1 19.06.44 | 09.04.64 1 52 f 20 1 20 [09.04.64 ( Yes j(Cf Block) (pet Cleaner Also Block Ref 1 1 J \ 06 |Ray 1I |f 11 [23.11.28 j BEG j ville 1 1 1 I1 1 nr [Louis- | 17.01.62 | 00.02.74 45 1 12 11 11 i---------------- r 12 [24.07.75 | Yes |(Cf Block) jus Air Force Also Block Ref 1 ^ |Austin I I J ville I i i [ II Louisville |Jones? i I I ! 1 ii I[ i I i i 1 iI 1 [i [Pot Cleaner j(Cf Block) Times 23.7./5 Retired April I l1 I1 ! i 1 II 11974 I l1 4J jj 11 07 [Charles |03.05.22 | ucc 1il |ii 1i i 1 [S Charle | 27.08.44 | 00.00.68 i 45 j 24 Il j 1 i1----------------1 -r 1 17 [23.03.68 | Yes |A!so Block ------------------------- if--------------------------- (Ref 1 |T Smart I 1 | ston 1 t i Jt jJ 1 ii 1i i f i oa I (06.OS. 20 | Goodyear |Niagara | 07.10.46 | 00.08.61 i 41 1 15 11 1 1 l1 1! 1 16 (29.08.61 ( Yes ------------------------- 1--------------------------(Ref 1 I [I I1 1 i 1 11 ( I II t 1I -i i1 i1 i1 i 1 I i i 11 1I X. 1 1 i 1 J 1 1 send 008288 Page USA - Sheet 2 LIVER Angiosarccna Cases - (Review Date; 1 Jan 1990} UK system of dates DAY - MONTH - YEAR T~--------------T 11 11 ! t COUNTRY AND [ 2 |3 l NAME OR j DATE OF \ 11 1 4 15 1 1 6 1 FIRST VC REFERENCE | INITIALS j BIRTH COMPANY | FACTORY EXPOSURE HO 1 1 1 09 [Raymond joa.11.31 BFG 1 1 1 [Louis- 23.05.45 | Get tie- ] ville [Finger? I I1 Ii II II ll 11 11 11 10 1 116.03.13 Goodyear | Niagara 12.06.51 1J 1! 1 j n1 |27.05.09 Goodyear |Niagara 14.10.46 i f i-----------------r 12 [Francis A jl7.ll.10 Firestone [Pottstownj 13.07.49 |Bachman [ Pa i Il i -j ii i] iI l1 1 1 i-- 1-----------------1 EE f T 13 | Richard jOt.12.21 UCC |S CharJe 1 11.12.42 |Edward i | ston |ciendenin 1 ]1 i1 i1 1 J i i (14) ! i 1 I1 1i 1i 1i 1 1 1 JI (15) 1 I1 t1 1 1 1 T 11 1 1 1j i i1 l1 I1 F 7 DATE OF 3 AGE AT 1 19 1 1 | YEARS OF TT i1 i ~t--------------------i------------------------ i il i 1n 12 1 13 1H ! J_________ ___________ J _i_____________ I t1 i[ | YEARS OF | DATE OF HISTOLOGICAL | ESTIMATED | j 15 OTHER 1 1 1 | 16 OTHER DIAGNOSIS DIAGNOSIS | EXPOSURE TO | EXPOSURE | DEATH CONFIRMATION | EXPOSURE | OCCUPATION j CAREER ! COMMENTS 01.03.74 j DIAGNOSIS 1 1 1 i1 1 \1 43 j 29 \ 24 ] 11.03.75 | LEVEL 1 j1 11 Yes [ 2000 ppm 1 | HIGHLIGHTS 1 1 1 |Ref 1 has I I1 | wrong figures I II [re first i ii |exposure. I i1 | Louisville i [1 | Times 1l I1 |29.10.74, lI Ii |12.3.75, 00.05.66 00.03.70 02.05.69 55 17 1 \ 61 1 23 50 20 1 1 1 1 n 110.05.68 1 1 j 23 |16.03.70 l 1 1 19 |02.05.69 i1 i1 11 [10.3.76 f l Yes 1 1 j Ref 1 r1 11 1 1 Yes 1 |Ref 1 -J 1\ 1 1 Yes |High 10 yrs|10 yrs as |Utility & |Ref 1 + letter l |reactor op. | Service op. |of 26 April t [(not cleaner|Bagger 11973 from i [- separate |Dryer op. !Russell A Park i |crew cleaned!Stripping P* to J T Seawell i |autoclaves) [3 yrs prior of NCA 11 00.05.74 52 32 i 1 11 1 1 26 [07,04.74 li i I 1 I Yes j 2000 ppm f i jservice in jtyre plant 1 I ! l 1 1 | Charleston [Daily Hail I1 t1 ii I i [21.7.75 1l tl I i I Never diag- I l nosed as ang- i ll iusarccna of i I liver. Inform-- [ i ation given in l l letter 22 May 1 1 1981 frtn 1 1 l --n1 r l 1 ! i J A Salg. 1 1 iI Accountant; 1 [ ASL - No evi- 1 l ________ _____ 1 _JL l i t f dence of V01 jexposure. GENC 008289 Page S'*. USA Sheet 3 T 1 ------ 1------ j------- ,----- ---LIVR Angiosarcoma Cases - (Review Date: l Jan 1990) \ l?K System of ilatns DAY - MONTH - YEAR COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH 16 James Howard 17 Peerenboca 06,05.31 18 Charlie 22,04.28 BFG Arthur FIRST VC EXPOSURE DATE OF [ AGE AT DIAGNOSIS [ DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF | HISTOLOGICAL DEATH | CONFIRMATION ESTIMATED EXPOSURE LEVEL OTHER CAREER HIGHLIGHTS OTHER COfflENTS Louis ville 00,00.69 I 41 19 04 27.03.69 1951-4 VCH Fran 1954 Table 4 in polymer onwards in Wagoner isation Amy and other Testimony to service. US Senate 46-50 Army Confirmed in ft N Johnson I ltr 07.08.78 Louis ville 23.06.55 11.10.74 43 16.10.80 Yes } on 11.10.74 but no post-mortem 16.10.80 l Dr ft N Johnson letter of 24.2.81 con firmed death 6 years after diagnosis Avon Lake 15.09.54 13 |02.11.75 I Yes 13 yrs Navy autocleaner 8 yrs on Estol Tyre Store plasticiser & Carboset operation Confirmed in ft H Johnson ltr 07.08.78 Also Rolling [Stone mag. (15.01.76 Virgil 00.00.15 Christian S Charle-I 00.00.43 ston 19.06.75 32 32 06.04.76 Yes 2000 ppm Chester Hinkle Goodyear Niagara S Charle ston 30.01.76 58 Early 77 67 30 22 02.01.77 Yes J___________ L |Williamsport |Sun Gazette j 21 June 1975 |Charleston |Daily Hail |21.7.75 [NOISH letter jof 25.10.79 I [28 yrs with |ucc at SC |Retired [Hews release [23.2.77 rjGENC 008290 USA - Sheet 4 LIVER Angiosarcci&a Cases * {Review Date: 1 Jan 1990) UX system of dates DAY - MONTH - YEAR 1 1 12 i 34s -- 1 1 67 a COUNTRY AMD NAME OR DATE OF REFERENCE INITIALS BIRTH CCKPANY HO l 1 ------------------ 1---------------- 22 [02.10.23 BFG I I i I I l I 1 i i I i l ! 1 [ | | 1 ------------------ 11---------------- 1 73 |00.00-23 Great l American [ Chemical Ca^any FACTORY FIRST VC EXPOSURE ---------------- 1 Louisville 11.07*47 r" Fitchburg 0a.09.5fl Kass. DATE OF DIAGNOSIS AGE AT DIAGNOSIS 00.01.76 52 1 06.04.73 50 1 ------------------------- 1-- 1 9 10 11 12 13 H 15 ___________ 1 _________ -- . i 16 YEARS OF EXPOSURE TO YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTMATED | EXPOSURE OCCUPATION OTHER CAREER OTHER CCfKENTS DIAGNOSIS | | 111 29 28 04.12.76 Ii lI ll Yes | LEVEL | 111 1 l 1I il iI HIGHLIGHTS Louisville Times 26.1.76 said he was the 10th AS ti jI It li lI II [I ll Il lI il 1I l1 !1 1i 11 11_J 15 14 06.04.73 II l[ II II l1 iI ii i( ii ii ii iI Ii iI ll ii 1 Yes i victim at Bells Lane of when 8 had died by 26.1.76 In his letter Oi 16.09.31 Dr H N Johnson confirms this is the case described bj Dannaher Tamburro & Yam in Feb 1980 Am J Medicine [Vol 70 p2B0 1-------------------------------------------------- [! li i1 1 1 (24) | Dele .ed 1990 bi . Bennett: Hot angiojsarccna, but confirmed C jolang iosarcces3 (25) si tl iI 1 Removal frco register confirmed in R Kaminski letter of 5 November 1980 j II 1 _______i ___________ ____________ 1 1 t l i | i 1 1 ll [i 11 1l ll 11 11 R N Wheeler letter of [20/2/79 and Rose Kaminski |letters of |26/2/79 and j 5/11/00 GENC 008291 LIVER ArHjjosaruumu Cases - (Review Date: J Jan 19'JO) UK system of dales - UAY - MONTH- YEA* USA - Sheet 5 l 2 3 4 56 7 8 I 9 10 11 12 1J 14 15 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF j j BIRTH [ COMPANY | FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS 16 OTHER CCffENTS 26 John Berry 07.07.23 BFG Louisviile 03.10.47 00.00.77 (up to 2 years after death) 52 (death) 23 (death) 18 11.02.75 Yea Exposed in Various jobs some degree in PYC to 22 plants firm chemicals cold room to but main paste exposure recovery to was to VCM, PVC charging probably operator to high paste charging. Ill August 1965. Terminated employment Jan 1966 R Kaminski letter of 26/2/79 and Prof, Tamburro letter of 9/1/79 27 J L 11.05.16 OCC Forrest S Charle 01.07.41 ston 30.11.78 62 37 20 25.11.78 Yes (NIOSH says 27 and C Daily Mail 25) High Operator to Exposure in R N Wheeler 10.10.76 bulk and Itr of 4 Jan dispersion PVC 1979 and manufacture Charleston Daily Hail 30.11.78 and R Kaminski 26/2/79 28 11.04.17 DCC S Charle 00.08.44 03.11.73 61 34 33 03.11.78 Yes ston R Kaminski letter of 6/4/79 29 12.10.07 ticc S Charle 00.05.42 00.03.80 72 38 16 01.03.80 Yes ! ston R Kaminski Letters of 19th June 1980 & 5th Nov 1980 30 WVN 22.07.22 Tenneco Fleoimgton 11.06.64 30.12.80 sa 17 15 30.12.80 Yes 6 ~ Unknown Maintenance Chemicals .i 9 - Minimal Mechanic I 6 yrs I Elsewhere i 1| yrs i Boiler house i Operator GENC 008292 USA ' SheeL 6 LIVER Hot/Eosarccxnu Casus - (Review Dale; L Jan 1990) UK system of dales PAY - MOMTtl - YEAR i ii 1 234 CCKWniY AND REFERENCE HO HAKE OR DATE OF INITIALS Biftra l i COMPANY 31 I 1 I J OS.11.23 i l I J UCC ll ll ll II ll iI 1l lr Il Il __ Ii i |-------------------- 1------------------------1------------------ 1-----------------1------------------------ 1--:------------- (----------------------- 1-------------------------T | S |6 1J 1i { | FIRST VC j FACTORY f EXPOSURE 7 DATE OF DIAGNOSIS 8 AGE AT DIAGNOSIS 9 YEARS OF EXPOSURE TO 10 1 u i 1 YEARS OF DATE OF EXPOSURE DEATH 12 J 13 1 ( HISTOLOGICAL | ESTIMATED CONFIRMATION 1 EXPOSURE 14 I OCCUPATION 15 OTHER CAREER 1 JG (-- OTHER COMMENTS ll 1 iii rr |S Cbarle-f 12.05.46 01.00.81 [ DIAGNOSIS 57 3S j -- 13 02.04.82 Yes 1 LEVEL 1-------------------'High (But Chemical HIGHLIGHTS From 1959 to Dr Dacey J ston | { l l not as high Operator in 1976 Aliphaticjletter i[ i I I as reactor charge Chemicals 16.10.81 and ii i I I cleaner reactor operator and R N Wheeler ii i l l would from July 1976Jletter of ii i 1 i experience) to date 9.11.81. Ii i I [ (Worked as Foreman Also Dr Dacey ii i I I labourer Aliphatic letter of ii i [ i from Chemical 07.03.83 re ii i l 1 June 1941 Operation .date of death. ii I l l to liar 19 i II ( l 1 land may (i i I I {have ' ii t 1 l |cleaned !1 I l l reactors in 1! that tine 32 C U Giroux 22-02-08 1! 11 11 1i 11 11 11 11 1I 11 i1 11 !1 11 1( 11 11 11 ----------------------- 1------------------ 1 Monsanto Springfield 15-10-51 00-07-79 1 toss 1 ( /1 1 11 1 1! I 1! 1 1 ^1 1 11 1 11 1 11 1 1f 1 11 1 [I 1 11 1 !1 1 11 I 11 I f1 1 11 1 ii_______________ _________ i 71 ( i 1 l I I I I l I i I I l l l l 1 ! 28 .13 S Ferguson 08-10-27 BFG |Jnr J l1 11 I1 /Louisville 09-09-54 11-05-82 iI I lI l 1i l 1l l 54 28 1 1 1 i 14 (io PVC 17-05-80 j An autopsy Ttte death 1940-1951 was done and |certificate!Various jobs Information (given in autoclave ) inmediate /gave in polymer letter of 24 area) / cause of |Sr Giroux' (manufacture (February 1982 i death given (usual |BITTYAR from Dr i as (occupation (LUSTRES |Walter C [ "Angiosarcoma" as "ketUe|l9M-l%4 Barnes of i J operator1' (Various jobs (Monsanto i in in and Springfield to i j"chemicals (around PVC Dr A Munn of i /industry"- (autoclaves (Monsanto i J964-1973 (Europe. i Various i (clerical i (jobs in PVC i (polymerisation i (facility/ i /Retired l 28 Alive es i /0I-03-7J. ------------------- j---------------------- ------------------------- 1--------------------------- | 1954-74 (Multiple |Prof Tamburro i (High (jobs letter of l I I975-B2 | Including U Aii(; I'JM t 1 (Low | toly (Dr H H Johnson l i /Operator * (letter of Polycleaner.I 128 Feb 1983. GEHC 008293 Page USA - Sheet 7 --------------1 --------------------1-- 2 34 ---------------------- 1 6 LIVER Angiosarcoma Cases - (Review Dale; l January 1990) UK systaa of dales - DAY - MONTH - YEAR ----------------1---------------- ---------------- 1 -- -- ------------------- -- 7|a * 10 n 12 13 14 15 16 1 __________ 1_________ 1 __________ I____________ ___________________________________________________________ YEARS OF HISTO- COUNTRY AND HUE OR DATE OF| FIRST VC |DATE OF |AGE AT EXPOSURE YEARS OF| DATE OF REFERENCE INITIALS | BTRTH COMPANY FACTORY EXPOSURE | DIAGHOSIS | DIAGNOSIS | TO exposure! death MO ---------------------- 1 -------------- 1-------------- 1 34 Hr Bjrutl 29-01-J4| BFG DIAGNOSIS -- ----------------1---------------- ----------------- ----------------1 Louisvill 1955 03-11-621 48 77 10 04.08.83 i ! [ [ 18-07-83j 71 I.OGICAL ESTIMATED) OTHER CONFIRM- [EXPOSURE 1 OCCUPATION [CAREER OTHER COWENTS ATION LEVEL Yes 1955-74 Poly HIGHLIGHTS| ___________ j_______________________________________________ 1 1965 left |Dr H H Johnson letter of 3 Hov 1982, [High Operator + BFG to 2B Feb 1983 and 9 August 1964. [1975-82 Autoclave beectne a i Cleaner Clergyman. 1953-65 35 36 1 09-03-12 ucc S Cbarle- 23-07-44 ston 1 l l 1 ----------------- 1--------------27-08-32 The GeneralAshtabula 11-06-56 21-08-03 j |Tire and J l |Rubber Co [ I i[ il i1 il iI il SO 39 27 14 18-07-83 Yes 27 Alive Yes High from 1944 to |1955. [Ned free | 1955-1958 , Moderate 1956-56 jlabourer | j 195-6-57 | |prod helper| 11957-70 j joperator [ j1970-75 f Jelectrician! |1975-present operator 37 |j Payton 29.08.29 BFG Louis- ' 1953 06.08,84 54 31 22 06.08.84 Yes High Worked 11 [villa 1 i 1 1 11 1f regularly | i1 1 1 1 ! 1 11 1| jin PVC area| 11 1 1 1 1 1 11 [j [in the | 1i 1 1 1 1 1 1 1 1 | j early days | 11 1 1 1 1 1 1i 1| |was a | 11 I11 1 1 11 1[ |reactor | 11 11 1 1 1 1 1 1 1 1 J |cleaner | 1 1 1 1 1 [1 1| j1953-75. j 11 1 1 1 1 1 11 1j 1 1 JHB |26.08.22|Air [Calvert [00.02.63 [19.01.84 1 6i 1 20 j 20 |28.10.83 1 Yes j High |Normal | | |Products [citr t 1 ! 1 1[ ! j1963-1982|progression| 11 111 i [ 11 [| |fron helper! t1 1 1 t 1 f 1 1 1 | !to senior | 11 1 i 1 I 1 1 1 1 | [operator | [1 1 1 1 1 [ 1 1 1 | [cleaned j 11 11 j I 1 1 1 I 1 1 | [reactors,, ! 1 1 1 1 1 1 1 1 | |stripping &[ 11 1 11 1 1 11 1| [recovery | 11 1 1 1 1 1 1 1 1 | jareas as j 1i 1 1 1 1 1 1 1 ) | |well as | I1 1. 1 1 1 [ I1 i| [charging | operator. Dr Dacey letter of 5 September 1963. R W Laundrie letter of 12 Sept 1983: spotted at medical Nay 1983. Testing camenced May 1983 Information given in letter 09.08.84 | free Dr H N Johnson 1 I l l [ i l llhrcnbo cytopenia and leukopenia Isince 1978. Gold treatment for arthritis |l976. Under Dr's care about 6 months |before death, had passed standard physical (examination 3 months earlier. J Barr [letters of 22.10.84 and 23.01.85. [ l I i I I. i GENC 008294 Page " y? USA Sheet 8 LIVER Angiosarcoma Cases - (Review Date; 1 January 1990) UK system of iLales DAY - MONTH - YEAR n 12 13 14 IS 16 COUOTRY AKD REFERENCE NO NAME OS INITIALS DATE OF BIRTH COMPANY 39 27.06.18 FIRST VC EXPOSURE YEARS OF DATE OF AGE AT EXPOSURE YEARS OF DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE OF DEATH HISTO LOGICAL ESTIMATED[ CONFIRM EXPOSURE |OCCUPATION ATION LEVEL | OTHER CAREER HIGHLIGHTS OTHER COWiEMTS I960 March 1984 23 29.06.84 Yes [ Low 29.09.60 - Worked May 66 before Vinyl 1960 ^Fabrication with US Plant Air High May 66 - Force, Aug 70 United Utilitf Wool Resin Dyers Operator and (inc Jal 66 Okanite - Sep 67 Reactor Operator) Low Sep 70-82 Monomer Operator Low 1982-83 Bill Operator, Calendar Shop, until retirement Never in hospital for any chronic or acute medical problems. Death certificate states cause of death cardio-pulmonary arrest secondary to angiosarcoma of liver. Letter of 15.07.86 from John E Ertel of Pantasote with letter of 24.02.86 frcm Dr Auerbach, Pathologist. PP Gilmer 26.10.14i BFG Louis ville 22.05.42 45 03.01.87 41 R Buckley 2.02.15 Goodyear Niagara 1949 Falls 1987 72 38 27 20.08.87 High Chemical Letter frcm Dr Dietz, BFG, 1942-1974|Worker 10.3.87 |1942-45 Low 1975-1976|Foreman |1945-76 ___________1_____________ ____________ High 1949-65 Retired | Chemical Op/ 1977 Letters from Prof Tanburro University of Louisville, 1987 Shift Sup/ (Age 62) and Dr C A Johnson, Goodyear, 1988 Foreman, | PVC Resin Production | Medium 1965-77 NF Plant ] f Left PVC area for 6 months in 19651 GENC 008295 Page r r> USASheet 9 IVER Angiosarcccaa Cases - (Review Date: l January 1990) UK system of dates DAY - MONTH - YEAR -- 1 12 4 1-- _____________ 1 ________________ ! 1 ti COUNTRY AND 'HAKE or DATE OF REFERENCE INITIALS BIRTH COMPANY NO 1---------------- 1 5 le !^ . ---- 89 1---------------- 10 1 u E . 12 ! *3 r --1------------------ ---------------------------------------------------------------- i-i 1 K 1 16 P 1------ -- ----- ------------------------------------------------------------- YEARS OF HISTO 1 FIRST VC !date of AGE AT EXPOSURE YEARS OF DATE OF LOGICAL ESTIMATED OTHER I FACTORY EXPOSURE DIAGNOSIS DIAGHOSIS TO EXPOSURE DEATH CONFIRM EXPOSDRE OCCUPATION CAREER OTHER COMKESTS DIAGHOSIS ATION LEVEL HIGHLIGHTS 42 McMullen 02.05.41 01 In Assonet 00.04.68 00.04.82 41 14 6 09.07.82 Yes High Labourer in Fot area: pot cleanou . regularly Letter from Dr Peter Hamill 13.04.89 43 J R 08.09.21 GeoCarp Ashtabula 14.04.55 26.11.88 67 Succi (formerly Ohio General Tire) 33 28 10.01.89 Yes PVC Resin Retired Letters from Roy N Johnson, GenCorp Plant: 01.01.B4 08.05.89 and 30.05.89 High Maintenance Cleaner 1.6 years Shift Medium Mechanic 2 years Plant Low Electrician 24.10 years QENC 0QS296 YUGOSLAVIA LIVER Angiosarccoe Cases - {Review Date: 1 Jan 1990) COUNTRY AND REFERENCE NO NAME OS INITIALS DATE OF BIRTH 13 YEARS Of FIRST VC DATE OF AGE AT EXPOSURE YEARS OF EXPOSURE DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE OF DEATH HISTO LOGICAL ESTIMATED OTHER CONFIRM EXPOSURE OCCUPATION CAREER * ATION LEVEL HIGHLIGHTS OTHER CMKENTS YUGOSLAVIA 01 05,04.14 Jugo Vinil Split 00.00.53 8.04.73 59 20 20 8.04.73 Yes SARIC et al paper Eav Health Perspective Vcl 17. pp 189-192 1976 02 15.11.31 Jugo Split 00.00.50 12.07.73 42 23 12.07.73 Yes* VCH Vinil Production *Io Ms letter of 3 Oct 1978, Dr Spirtas of NIOSH changed the status of Case 02 to VCN production employee. Dr Spirtas also notified a new Case 03 also a VCH production worker. 03 21.12.31 Jugo Split 04.06.54 45 22 11.01.76 Yes* VCH Vinil A- Production 04 11.06.30 Jugo Split 15.12.58 03.09.78 Vinil 03.09.78 Rose Kaminski letter of 19 June 1980 and IARC letter of 1 April 1982 GENC 008297 Page i|0 Incidence of ASL Cases Per Annum - By Date of Death 1955 .......................................................................................... 1 60 7 .......................................................................................... 1 8 ........................................................................ 0 90 1960 .......................................................................................... 0 1 .......................................................................................... 1 21 3 .......................................................................................... 0 4 .......................................................................................... 2 5 .......................................................................................... 0 6 .......................................................................................... 0 7 .......................................................................................... 1 8 .......................................................................................... 5 9 .......................................................................................... 3 1970 ......................................................................................... 2 1 .......................................................................................... 3 2 ......................................................................................... 5 3 ......................................................................................... 8 4 ...............................................................^..................... 5 5 .......................................................................................... 11 6 .......................................................................................... 11 7 ......................................................................................... 8 8 .......................................................................................... 10 95 1980 .......................................................................................... 10 1 ......................................................................................... 5 2 ......................................................................................... 3 3 .......................................................................................... 10 4 ......................................................................................... 8 5 ......................................................................................... 8 6 .......................................................................................... 11 7 ......................................................................................... 3 8 ......................................................................................... 7 9 ......................................................................................... 5 Total 153 TABLE 1 (Review Date - 1 Jan 1990) NOTES 1 Does not include Italian 01. 2 The 1977 total now excludes US24, Cholangiosarcoma: deleted. 3 The 1982 total now excludes G26 Alcoholic Cirrhosis: deleted. 4 Does not include the following who are still alive, so far as known: FrlS and 28, US33 and 36. GENC 003298 Page 'n Distribution of ASL Cases by Country TABLE 2 (Review Date - 1 January 1990) USA W Germany France UK Canada Sweden Italy Yugoslavia Japan Czechoslovakia Belgium Norway Spain Total 3 ^ * * ***** ^ ***** 28 ** 16 13 5 ******* 6* 4 **** 3 s-' 2 2 1 1 157 ie Western Europe North America Rest of World Total 96 52 9 -- 157 ___ * Omit ItOl - atypical case of PVC bag extruder. ** Includes Frl5 and 28, US33 & 36, who are still alive, *** Includes one monomer worker. **** Includes two monomer workers. ***** Excludes G26 and US 24: deleted. so far as known. GENC 00S29? Page 42 Pattern of. ASL Cases by Factory TABLE 3 {Review Date - 1 Jan 1990) (a) W Europe Of the 96 cases in W Europe, 79 have occurred in clusters at 10 factories. Of the 37 German cases, 34 have occurred in clusters at 4 factories. ASL Cases Dynamit (now Huls), Troisdorf, Germany BP, Barry, UK Atochem (formerly Chloe Chimie, formerly RP), St Fons, France Wacker, Burghausen, Germany Atochem (formerly PCUK) Brignoud, France Kemanord, Sundsvall, Sweden ICI, Hillhouse, UK Solvay, Tavaux, France CWH/Huls, Marl, Germany Lonza, Waldshut, Germany 18 11 11 10 8 .5 5 5 3 3 79 NB: There are 32 pre 1962 PVC plants in W Europe; 20 of these have had ASL cases (Ref Table 8) (b) N America Of the 52 cases in N America, 41 have occurred at four factories out of a total of 55 factories. In N America 41 plants have not had ASL cases. ASL Cases BEG, Louisville, US BFG, Shawinigan, Canada UCC, S Charleston, US Goodyear, Niagara Falls, US 15 12 9 _5 41 NB: There are 29 pre 1962 PVC plants in N America; 13 of these have had ASL cases (Ref Tables 9 & 10) (c) Rest of World The 9 ASL cases are believed to be in one cluster of 4 and two clusters of 2 cases. Page 4} TABLE 4A (Review Date - 1 Jan 1990) Latency Periods (Years from first Exposure to Diagnosis) Country No of Cases W Europe Belgium France Germany 2 28 37 Italy 6 Norway 1 Spain Sweden UK 1 5 16 96 Total Years 35 795 765 127 22 25 122 376 2267 Average 17.50 28.39 * 20.67 * 21.16 22.00 25.00 24.50 23.50 * 23.61 W Europe Average N America US Canada 39 1002 25.69 * 13 314 24.15 * 52 1316- 25.30 N America Average Rest of World Czechos 1ovale i a Japan Yugoslavia 2 3 4 9 30 15.00 59 19.66 85 21.20 174 19.33 Rest of World Averag Summary W Europe N America Rest of World 96 52 9 157 2267 1316 174 3757 23.61 25.30 19.33 23.92 * World Average Of the countries with > 10 cases, France USA & Canada have an average latency period above world average; Germany & UK below world average. Page 44 DISTRIBUTION OF LATENCY PERIODS TABLE 4B (Review Date - 1 Jan 1990) i 1 1 i 1 1 1 | Belgium 0-9 yrs ; | Canada j Czechoslovakia | France J Germany i Italy Japan Norway Spain Sweden OK i USA Yugoslavia 1 tI 1 10-14 yrs 15-19 yrs | 20-24 yrs I 25-29 yrs I1 11 11 11 2 3 52 11 1 4 3 10 5 11 10 6 2 22 n--------------- i 1 1 11 || Average 30-34 yrs | 35+ yrs | | Total | | Latency 1 I! || Period 1 II [|(Table 4A) u__________ LI______________ rr 11 1 2 II 17-50 I 11 1 21 13 M 24.15 i 11 t 2 || 15.00 1 11 4 o1 28 1 | 28.39 1 11 4 37 1 20.67 1 1I 6 21.16 1 2: 1 1 3 19.66 1 22.00 1 1 25.00 2 21 5 24.50 5 163 16 23.50 3 7 9 8 6 6 39 26. 10 4 4 21.20 TOTAL 2 13 35 37 37 19 14 157 24.03 GENC 003302 Page -t (Review date 1 January 1990) TABLE 4G LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE MAX POSSIBLE LATENCY PERIOD YEAR OF FIRST EXPOSURE LATENCY PERIOD (NO OF YEARS) ARITHMETIC MEAN OF LATENCY PERIODS 50 1939 49 1940 298 = 37.25 48 1 37,21,37,41 8 47 2 32,38,45,47** 46 38,14,32,42,45 28,11,24,20,24,34,39, 886 = 28.58 44 31 27,22,28,29,37 21,29,31,26,28,15,23, 30,35 42 29,24,29,28 41 8 28,24,34 9 30,26,20,38 559 = 25.41 1950 26,22,31,19,23,14,33 22 1 19,28,17,28,34,29 37 2 21*. 15 36 25,23,22,20,31,22, 32,30,23 21,21,25,25,21,28**, 22,34,34 1010 = 24.04 22,23,24,14,19,21,27 42 27** 24,28,30,33 21,12,27** 32,29 32 19,17,15,13,16,28,30 31 8 18,18,15,17,20,29,28 9 16,21,25,27 598 19.29 1960 13,18,21,25,24,25 31 1 15,16,16,16,19,19,12 27 2 13,18,17,12,18,21,26 26 16,17,20,21,25,25,26 16,17,25 322 = 18.94 11,19,20 17 9,18,21 V 22 16 21 8 18,5,18,14 9 13,16 1970 1 17 2 84 = 14.00 6 VIOLA 16 TOTAL 157 CASES 3757 = 23.92 157 MALTONI GOODRICH * Aerosol can filler G 03. ** The following are still alive, so far as known Frl5 and 28, US33 and 36. 6B-\C 008303 Page (Review date 1 January 1990) TABLE AD LATENCY PERIODS OF ASL GASES TABULATED BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION MAX POSSIBLE LATENCY PERIOD 50 A9 48 47 46 42 41 37 36 32 31 27 26 22 YEAR OF FIRST EXPOSURE 1939 1940 1 2 3 4 5 6 7 8 9 1950 1 2 3 4 5 6 7 8 9 1960 1 2 3 4 5 6 7 LATENCY PERIODS IN WESTERN EUROPE NORTH AMERICA 37,41 47** 38,45 28,44 27 21,29,31,33 29 28,34 30,26 26,22,31 19,28,34,29, 21* 25,22,32,30,23 21,21,25,25,34,34 22,23,24,27**24,28 30 21,12,32,29 19,17,15,13,28 18,18,29,28 16,21,25,27, 13,18,21,25,25 15,16,16,16,19,19 13,18,17,18,21,26 16,17,21,25,25,26 16,25 11,19 9,18,21 16 21,37 32,38,45 14,32,42 11,24,20,24,34,39 22,28,29,37 26,28,15,23,30,35 24,29,28 24 20,38 19 17,28 15 23,31 21,28** 14,19,21,27,33 27** 30 15 24 12 12 20 17 ROW 23,14 22,20 22 16 17,20 20 21 8 18,5,18 v 14 9 13,16 VIOLA 1970 1 2 MALTONI 3 TOTAL CASES 96 52 9 * Aerosol can filler G 03. ** The fHwinS are stiH alive, so far as known Frl5 and 28, US33 and 36 GEHC 008304 f Page (Review date 1 January 1990) TABLE 4E PLANT START UP DATE LATENCY PERIODS OF ASL CASES IN SPECIFIC PLANTS (10 OR MORE CASES) NO OF AVERAGE CASES LATENCY PERIOD TROISDORF W GERMANY LOUISVILLE USA SHAWINIGAN CANADA BARRY UK ST FONS FRANCE BURGHAUSEN W GERMANY 1954 12,13,16,16,18,19,19,21,23,25,28,29,29, 5,23,16,34,18 1940? 12,14,15,19,19,20,24,27,28,28,28,29,29, 31,45 1943 11,12,14,21,22,23,24,24,26,28,42,37 (1941?) 1948 9,17,18,28,31,33,18,19,18,21,32 1939 21,28,29,37,38,27,41,34,44,34,47 1933 17,21,22,25,24,13,21,32,30,30 18 15 12 11 11 10 20.22 24.53 23.66 22.18 34.54 23.50 GENC 008305 Page TABLE 4F (Review date 1 January 1990) LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (10 OR MORE CASES) -- YEAR OF FIRST TROISDORF EXPOSURE W GERMANY ------ LOUISVILLE SHAWINIGAN BARRY ST FONS BURGHAUSEN USA CANADA UK FRANCE W GERMANY 1939 1940 1 2 3 4 5 6 >7 20 28,29,27 29,28 21 14,42 11,24 22,37 26,28 24 37,41 47 38 44 29 8 9 1950 1 2 3 4 5 6 7 29 23 21,25,34 23,28 12,29 13 24 19 15 31 28 14,19 23 31,33 28 28,34 34 27 32 21 25,32,30 21 22,24,30 17 8 9 1960 1 16,16,19,19 12 2 18 12 18 21 3 17 4 5 19 6 9,18,21 7 8 9 1970 5,18 16 1 2 ________________________ -- ____ _________________________ v 18 13 _______________________ _________________________ GENC 008306 Page Lit! (Review date 1 January 1990) TABLE 4G PLANT START-UP DATE LATENCY PERIOD OF ASL CASES NO OF IN SPECIFIC PLANTS(4-9 CASES) CASES S CHARLESTON USA 1939? 24,30,32,32,34,35,37,38,39 9 AVERAGE PERIOD 33.44 BRIGNOUD FRANCE 1950 11,16,18,26,30,25,34,45 8 25.62 SUNDSVALL SWEDEN 1945 16,19,27,29,31 5 24.40 NIAGARA FALLS I USA 1947 15,17,21,23,38 5 22.80 TAVAUX FRANCE 1953 19,16,21,26,25 5 21.40 HILLHOUSE UK 1940 28,25,28,25,26 5 26.40 SPLIT YUGOSLAVIA 1950 20,20,22,23 4 21.25 GENC 00830? TABLE 4H Page 2(Review date 1 January 1990) LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (4-9 CASES) '~ YEAR OF l |S CHARLESTON FIRST EXPOSURE| USA 1939 1940 1 I 1 | j BRIGNOUD FRANCE ----------------- 1----------------- SUNDSVALL NIAGARA| TAVAUX HILLHOUSE SPLIT SWEDEN FALLS I FRANCE UK YUGOSLAVIA USA | I 1 1 1 1 2 3 4 `5 | 37 | 32,38 j 32 | 24,34,39 j 45 27* 1 1 1 I 28 1 6 | 30,35 71 ___________________ _________________ 1 8j 9j 26,30 1950 | 1| 2j 34 ___________________ _________________ 1 31 41 51 31 29 19 15,23 | I 1 1 38 | 1 17 | 1 1 1 [ 21 | 23* 20 25 22* 61 1 7 8 9 1960 1 1 1 [ 1 j 18 16 f 25 11 2| ___________________ _________________ 1 31 4I 51 ii 6| 16 | 19 1 1 1 1 1 1 | 26 1 1 I 16,21,25 1 1 1 28 25,26 1---------------------| 20 1 I 1 1 1 1 1 1 71 ___________________ _________________ 1 8j 9 1970 1 I | | 21 ----------------------------- 1________________ 11 |1 -------------------- 1---------------------- \1 11 1 1| 1 1| 1 1| 1 11 ______________ ___________ 1___________ l i *Monomer worker GENC 00830S Page 5^ TABLE 5 (Review Date - 1 Jan 1990) Annual Incidence of ASL Cases (Date of Death) by Geographical Area 1 1955 7 1961 2 4 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980 1 2 3 4 5 6 7 8 9 Western Europe North America Rest of World Annual Total 1 1 1 1 4 .1 3 6 6 6 7 5 6 5 7' 6 7 10 7 4 1 1 1 1 1 5 2 1 2 1 4 2 4 3 2 2 4 3 3 2 1 3 1 1 1 1 1 12 1 5 3 2 3 5 38 5 1 11 2 11 8 1 10 5 10 5 3 10 8 18 11 3 7 5 Cumulative Total 1 2 3 4 6 7 12 15 17 20 25 33 38 49 60 68 78 83 93 98 101 111 119 127 138 141 148 153 TOTAL 94* ** 50** __________________________ ______________________ i_____________________ * Omits It 01 bag extruder 9 153 _______________________ Key Events Viola Maltoni Goodrich 1 1 j ** Does not include the following who are still alive, so far as known: Frl5 and 28, US33 & 36 NOTE: G26 and US24 deleted. GENC 00830? Page T'T (Review date 1 January 1990) TABLE 6 ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING It. 01) KEY EVENTS WESTERN EUROPE NORTH AMERICA REST OF WORLD 1955 6 7 8 9 1960 1 2 3 4 5 6 7 8 9 Viola 1970 1 2 Maltoni 3 Goodrich 4 5 6 7 8 9 1980 1 2 3 4 5 6 7 8 9 TOTAL Cl C2 US 8 C3 US 5 Cz2 FI C4,C5,US4,US7,US10 G1 US12.US16 Swl US 11 G2 Nl,Sw2,UKl,It2 C6,US2 C7 G3* C8,US1,US3,US23 Yl,Y2,Czl G4,G5,UK3 C9,US13 F2,F3,G6,G7,G8,It3 Bl,F4,F5,F6,F7,Sw3 F8,F9,G10,Gll,G12,Sw4 F10,F11,G9,G13,G15 G16.G17 F12,F13,UK4,UK5,G18 UK6, UK7,G19,Sw5,G20,G21US It4,F14,UK8,G22,G23 UK09, It5,F17,B2,G24,G25,G30 UK10,F16,F18,G27,G29,G35 UK11,UK12,F19,F20,G28,G33, G34 F21,UK13,It6,It7,G31,G32, G36,G37,G38,G39 F25,F26,UK14,UK15,UK16 F22,F23,F24,F27,Spl,UK17 US6,US9,US18,US26 US19,US20,US22, C10,US21, US27,US28 US17, US29, US30.US32 US31,US42,C12 US35, US34, US38 US37.US39 Cll US40,US41,C13 US43 Japl Jap2,Y3 Y4 Jap3 94** 50** 9 * Aerosol can filler (G3) ** Does not include the following who are still alive, so far as known: F15 and 28, US33 and 36 NOTE: G26 and US24 deleted. GENC 003310 Page ,)J (Review date 1 January 1990) TABLE 7 ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION (EXCLUDING It,01) KEY EVENTS WESTERN EUROPE NORTH AMERICA REST OF WORLD 1939 40 1 2 3 4 5 6 7 8 9 50 1 2 3 4 5 6 7 8 9 60 1 2 3 4 5 6 7 8 9 Frll,Frl6 Fr28** Frl4,Fr24 UK1,Fr23 Sw2 Frl,Fr3,Sw4 Sw3 Fr9, Frl7 Frl2,Fr4 Fr7,Nl,UK8,UK9 Swl,UK5,Fr20,G30 G3* G15,It3,G31,G33,G36 G7,G8,G19,G38,Fr27,UK4 Gil,G16,G18,G23,G28, G32,Frl5** FR10,G1,G34,UK15 Fr8,G4,It2,G2,UK12 Fr6,Bl,Fr22,It7 Fr2,It4,Frl9,Fr21 G5,G13,G25,G28,It6 G9,G10,G12,G17,G20,G22 G6, UK6, G21, B2, G29, Fr 25 Frl3,Frl8,Fr26,UK7, UK16.UK17 Sw5,Spl Fr5,UKll UK3, UK10.UK14 It5 UK13,G35,G39 G24.G37 C3.US27 US13, US29.US40 C2,US19,C11' Cl,C5,US5,US7,US28,US35 C4,US3,US9,C12 C7,C9,US8,US11,US21,US31 C6.US22.US26 US1 US12.US41 US16 Y2, Cz2 US10, US32 US 4 CIO, US37 Japl.Yl US18.US33** Y3 US2,US17,US20,US34,US43 US36** C13 US23 Czl Jap2,Y4 US39 C8 US 6 US38 US30 Jap3 US42 Viola 70 1 2 Maltoni 3 Total 96 52 9 * Aerosol can filler (G3) ** Frl5, Fr28, US33 & 36 are still alive, so far as known NOTE: G26 and US24 deleted. 6EWC TABLE 6 WESTERN EUROPE PVC PRODUCERS - START-UP DATES vs ASL CASES (OMITTING GQ3 S It.01) 1 1 1 T------------------------------- 1------------------------------1-----------------------------------------1 |START-UPf COUNTRY NAME ( COMPANY NAME I LOCATION ( ASL CASE NUMBER j YEAR OF | YEAR 1 J_____________ 1 1 1 1st Exposure i 1931 Iwest Germany Ibasf 1 Ludwiashafen 1 1 1933 |West Germany |Wacker |Burghausen 104,07,11,15,23,24157,54,55,53,55,69,60,501 11 1 125.31,32,33 155,53 i 1938 1 Italy 1939 |Prance iMontecatini [Acna |Rhone-Poulenc/ |st Fons 1 |03,09,10,11,14 1 |46,48,56,41,43, ! | 1 Ichloe/Atochem 1 115.16,17,23,27,28155,41,48,44,54.47 1940 1 United Kinadom1ICI/EVC 1 Runcorn (Closed 1948) 1 1 United Kingdom 1ICI/EVC 1Hillbouse 101.04,12.16,17 144.54,57.63,63 1945 1 Sweden iKemanord/Nobel ISundsvallfStockvik 101,02,03,04,05 151,45,47,46,64 ! 1946 France 1Rhone-Poulenc 1 Roussillon loi 146 : 1948 | United Kingdora|BP Chem/ICI/EVC |Barry |03,05,06,07,08,09|66,51,62,63,50,50 1 11 1 110,11,13,14,15 166,65,68,66,36 i IWest Germany ICWH/Huls iMarl 109.10.29 161,61,62, i 1949 l&elaium Isolvay 1 Jetnenpe 101.02 158.62 1 1950 |France |PCUK/Atochem |Brignoud |02,04,05,06,12,19|59,49,65,58,49,59, | 11 1 120,24 151,43 i | France |Rhone-Poulenc/ (St Auban (07,22 |50,58 ! 1 Ichloe/Atochem 1 11 1 Holland 1 Shell Ipemis, Rotterdam 1 I 1 Norway 1 Norsk iHeroya, Porsgrunn loi (50 1951 1 Switzerland iLonza/ICI/EVC ISins 1 1 1952 | Italy |Montedison/ |Temi j 07 158 1 iMoplefan 1 11 1 Italy 1Montedison/EVC 1 Porto Karghera 102.06 157,60 1953 [Austria lHalvic/Solvay lHallein 1 1 1 France 1Solvav 1Tavaux 108,13,18,25.26 157,63,63,62.63 : [Italy 1Solvay 1 Ferrara 103 1 S3 ; |Spain (Rio Rodano iHemani 1 1 i |United Kingdom|BXL/BIP/NORSK |Aycliffe 1 1 ! Iwest Germany iHoechst iGendorf 118 155 i 1954 (West Germany |Dyuamit/Huls |Troisdorf 1 |(since 1,1.89) 1 (01,02,08,12,16,17j56,57,54,61,55,61, j19,20,21,22,27,30(54,61,62,61,55,51 1 i !1 1 134,35,36,37,38.39156.68,53,69.54.68 i 1955 1 Spain 1Monsanto IberiaiMonzon I 1 1 1956 |Spain ICaiqsa 1 11 ; 1 1Hisnavic/SolvaviTorrelavega 101 164 1958 Iwest Germany 1Solvay iRheinberg 1 1 i 1960 |Italy lANIC/SC Ravennaj 11 ! 1 I/EVC 1 Ravenna 104 159 1 IWest Germany (Lonza/ICI/EVC IWaldshut 106,13,28 162,60.60 1 1961 1 Italy 1Montedison/EVC 1Brindisi JI1 1962 1Portuaal Icires lOoorto JIi 1965 1 France 1Rhone-Poulenc iMontlucon IZ1_________________ [59_______________________ | 1Italy 1 Italy IPozzi Ipensac 1 Ferrandina iMira, Venice JI1 105 !67 I IWest Germany 1Wacker 1 Cologne J1 i 1966 1967 Iwest Getmany |France ISoain 1 Greece IHoechst 1Atochem iRio Rodano lEsso Panoas 1 KnaosackfFrankfurt)105* iBalan J1 i 1 Miranda de Ebro 1 (Diavata Salonika 1 160 !...................... 1 1 1 i 1968 1969 1 Belgium iBadiDhil limited KingdomIVinatex/Norsk 1 Italy________ iRumanica/EVC 1 Antwerp 1Stavelev 1 Cagliari Sardina I1 Ii Jli Continued l : 6EMC 008312 Page Table 8 - Continued WESTERN EUROPE PVC PRODUCERS - START UP DATES vs ASL CASES (OMITTING G03 & It.Oil* 1----------------1------------------------- 1---------------------------- 1--------------------------------- I ------------------------1-- |START-UP| COUNTRY NAME | COMPANY NAME | LOCATION | ASL CASE NUMBER | 1 YEAR 1 1 l 11 | 1970 1 Italy__________ 1 SIR 1 Porto Torres Sar 1 1 lUnited Kingdom 1ICI/EVC iRuncom 1 1 1 1971 1SDain iHispavic/SolvavlMartorell 1 1 1 Sweden iKemanord/Norsk IStenunesund 1 1 1 United KinedomlBP (Ihpjn iBaelan Bav 1 1 | 1972 1 Finland 1Pekema 1Svartback 1 1 1 Holland IDSM iBeek Limbure l 1 | 1976 |France |Soc Art D'vinyl|Mazingarbe l 1 1 1(CDF) I 11 1 1977 1 Spain 1 Monsanto IberiaiTarraeona 1 1 | 1982 |West Germany |ICI/EVC |Voslapp 1 1 J______________ 1 IWilhelmshaven i u_ I___________ I___________________ I____________________ I_________________________ 1_______________________ 1 YEAR OF 1st Exposure ------- 1 1 | 1 | | | | | | 1 | | 1 | * Laboratory worker in Research Department GENC 008313 Page i (Review date 1 January 1990) TABLE 9 USA PVC PRODUCERS - START-UP DATES vs ASL CASES 1 ---------------------------------------------------------------1 START-UP COMPANY NAME YEAR LOCATION | ASL CASE j NUMBER YEAR OF | 1st EXPOSURE | 1939? *UCC Dow S Charleston Midland (made | 07,13,19,21,27 128,29,31,35 | 44,42,43,46,41 44,42,46,44 | j Saran copolymer) I 1940? *BFG Louisville |01,02,03,04,05, 48,55,45,52,44, | 106,09,16,17,22, 62,45,50,55,47, | 1946 *UCC/Dow 126,33,34,37,40 47,54,55,53,42 | Texas City (Partially closed 1977) 1947 Goodyear Niaqara Falls 108,10,11,20,41 46,51,46,55,49 | 1948 Firestone/ Occidental Pottstown |12 j 49 | Uniroyal Painesville (closed 1975) | | 1950 Monsanto Springfield |32 51 | (Closed 1975 I 1952 Dow Midland (No PVC since c 1975) BFG Avon Lake |18 54 | 1953 1954 Diamond/BFG General Tire/ ** Deer Park Ashtabula | j36,43 56,55 | DiversiTech (Closed 1983, Reopened 1986 by Vyqen) | 1956 Air Products Pensacola (Pace) I Atlantic Refininq Brooklyn(Closed late 1960s) Borden Leominster (Closed 1984) Conoco Hebronville (Closed 1975) BFG Niagara i Great American Fitchburg |23 58 | Plastics (Closed 1983) | Hooker Hicksville (Closed 1980-81) Pantasote Passaic(Closed 1984) 39 60 | 1957 Atlantic Tubinq Cranston (Closed 1967) Tenneco/ Occidental Flemington NJ (Closed 1985) |30 | 59 | 1958 Keysor Century Saugus, Cal | Air Products Calvert City(Paducah) 38 |63 | (Closed March 1982 Re-opened October 1983) I 1960 BFG Long Beach, Cal (No PVC now. Formerly shown as Watson) 1962 Borden Illiopolis Tenneco/Occidental Burlington NJ V| I 1963 Conoco/Vista Aberdeen, Miss I Stauffer Lonq Beach, Cal (Closed 1982) 1965 Conoco/Olin Assonet, Mass [ 42 68 | (Closed by Olin 1975) Ethyl Baton Rouqe (Closed 1984) 1966 Diamond/Georgia Delaware City | Gulf Gen Tire/Pantasote 1 Mt Pleasant W Va I(Closed 1982) 1967 BFG Stauffer/Formosa Allied/Robintech/ Georqia Pacific Hooker/Occidental Henry, 111 | Delaware City (Sold to Formosa 1981) Painesville, O. (No PVC made by Robintech. GP converted to polystyrene) Burlington NJ 1 | | 1 1 1968 Firestone/Occidental Perryville (Closed 1982) 1 Continued SENC 008314 Page 57 TABLE 9 (Continued) USA PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP YEAR 1969 1971 1972 1973 1974 1975 1979 1983 1986 COMPANY NAME BFG Goodyear/BFG Conoco/Vista Nat Starch Borden Atlantic Tubing/ Tallyrand Shintech Certain-teed Georgia Pacific/ Georgia Gulf Tenneco/Occidental Firestone/ Occidental Formosa Vygen ** LOCATION Pedricktown NJ Plaauemine Oklahoma City Meredosia, 111 Springfield Cranston RI (Closet ASL CASE NUMBER 1982) Freeport, Tex Lake Charles Plaquemine, La Pasadena, Tex Addis (formerly she5wn as Plaquemine) Point Comfort, Tex Ashtabula, Ohio YEAR OF 1st EXPOSURE My databank has no information on UCC before 1946 or BFG before 1950 ** Refer to same plant at Ashtabula, bought by Vygen from DiversiTech. NB Some of the plants in this list were closed down, some have changed ownership over the years, some have changed their product. Page _ : (Review date 1 January 1990) TABLE 10 CANADIAN PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP YEAR COMPANY NAME LOCATION 1943 (1941?) Goodrich Shawinigan (Formerly Gulf) (Formerly Shawinigan (Chemicals) (Formerly Canadian Resins & Chemicals) ASL CASE NUMBER YEAR OF 1st EXPOSURE 01,02,03,04,05 44,43,41,45,44, 06,07,08,09,10, 47,46,61,46,53 11,12 43,45 1951 Monsanto La Salle (Closed 1' >75) 1957 Goodrich Welland (Niagara) 13 57 1966 Esso (Imperial Oil) Sarnia 1979 Diamond Shamrock Alb/ Fort Saskatchewan BF Goodrich GENC 003316 Page y'j (Review date 1 January 1990) TABLE 11 EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASL CASES 1----------------1------------------------- ~\ 1 |START-UP| COUNTRY NAME | COMPANY NAME | LOCATION "1----------------------------1------------------------- | ASL CASE | YEAR OF 1 YEAR 1 1 .1 1 NUMBER 1 1st Exoosure iPre 19391East Germanv 1 State Comoanv 1Schooau 1 1 1 1941 1 Russia 1 State Comes iviadimir et al 1 J 1 1950 1 Yugoslavia ljueo Vinil ISolit 101.02.03.04 153.50.54.58 1 1951 1 Czechoslovakia!State Comos iNovakv 101.02 157.50 1 1955 lEast Germanv 1 State Comos iBitterfeldt 1 1 1 1956 1 Rumania 1 State Comos 1Icechim 1 1 1 1957 1 Poland tState Comos lOsweicim (Dworv) 1 1 |Rumania |State Comps (Tirnaveni 1 1 I .. 1 iTurda 1 1 1 1958 1 Rumania 1 State Comos 1Risnov L_ 1 1959 iHunearv 1 State Comos iBerente Borsod 1 1 1 1961 1 Rumania 1 State Comos iBorzesti 1 I 1 1963 1Yueoslavia lohis ISkooie 1 1 1 1965 iBulearia 1 State Comos 1 Varna 1 J 1 1967 1 Poland 1 State Comos iTamow 1 -J. 1 1969 1 Russia 1 State Comos iDieriinsk 1 1 | 1970 1 Rumania 1 State Comos iRimnicu Vilcea 1 J 1 Russia 1 State Comos 1Voleoerad 1 J 1 1 1972 1Yueoslavia IVinilolastika 1 Zadar 1 | 1975 1 Czechoslovakia!State Comos 1Neratovice 1 1 1Russia 1 State Comos iKalush Area 1 1 1 1976 1Yueoslavia Jhe_____________ 1Pancevo 1 _L 1 1977 1 Rumania 1 State Comos IRimnicu Vilcea 1 1 J 1111111 GENC 00831? Page '0 (Review date 1 January 1990) TABLE 12 JAPANESE PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP YEAR COMPANY NAME LOCATION ASL CASE NUMBER YEAR OF 1st EXPOSURE 1950 1951 1952 1951 1955 1956 1957 1960 1964 1966 1967 1968 1970 1971 1973 1974 1975 1977 Chisso Corp Kanegafuchi Kag Tekkosha Mitsui Toatsu Mitsubishi Mon Sumitomo Kag Denki Kagaku Nippon Zeon Toa Gosei Ryo-Nichi Nippon Zeon Nisshin Kagaku Kureha Kasei Shinetsu Kag Denki Kagaku Kanegafuchi Kag Chisso Corp Tokuyama Seksui San Arrow Kagak Sumitomo Kag Ryo-Nichi Shinetsu Kag Chisso Corp Denki Kagaku Kanegafuchi Kag Kawasaki Yuki Mitsui Toatsu Nissan Kagaku Shinetsu Kag Tekkosha Asahi Glass Toyo Soda Central Kagaku Toyo Soda Unknown Minamata Osaka Sakata Nagoya Yokkaichi Kikumoto Shibukawa Kambara Tokushima Uozu Takoaka Takeo Nishiki Naoetsu Ohmi Takasago Chiba Tokuyama Tokuyama Chiba Mizushima Tokuyama Mizushima Goi (Chiba) Kashima Kawasaki Sakai Chiba Kashima Yokkaichi Hayatsuki Sakata Yokkaishi Kawasaki Yokkaichi Kashima V 02 01, 03 58 53, 65 GENC 008318 Page (Review date 1 January 1990) TABLE U SOUTH AND CENTRAL AMERICAN PVC PRODUCERS START-UP YEAR 1953 1954 1955 1956 1960 1961 1965 1966 1967 1968 1970 1971 1975 1976 1977 1978 1979 COMPANY NAME Monsanto Mexica Policyd Geon Do Brazil Elchlor/Solvay Electrochlor Viplastic Indupa PET Columbiana Carburo De Col Plasticos Omega SOC Paramonga Primex Policasa Petro Dow Polimeros Mex Rico Chemicals Petroplas Indust Resistoc Huls Brasil Polychem Policyd PET Camacari LOCATION Lecheria (Mexico) Mexico City (Mexico) Sao Paulo (Brazil) Sao Caetano (Brazil) Capitan Bermudez(Argentina) Mendoz (Argentina) Cinco Saltos (Argentina) Cartagena (Colombia) Medellin (Colombia) Mexico Paramonga (Peru) Puebla (Mexico) Managua (Nicaragua) Conception (Chile) St Martin Puebla (Mexico) Guyanilla (Puerto Rico) EL Tablazo (Venezuela) Tlazcala (Mexico) Cubato (Brazil) El Salvador Coatzacoalcos (Mexico) Camacari Bahia (Brazil! ASL CASE NUMBER YEAR OF 1st EXPOSURE GENC 00S319 Page (Review date 1 January 1990) TABLE 14 AUSTRALASIAN PVC PRODUCERS START-UP DATES START-UP YEAR COMPANY NAME Mid 1950s ICI Australia 1960s ' B F Goodrich Late 1970s ICI Australia LOCATION Botany, Sydney Melbourne Laverton Melbourne ASL CASE NUMBER YEAR OF 1st EXPOSURE QENC 0033 Page (Review date 1 January 1990) TABLE 15 MIDDLE EASTERN PVC PRODUCERS START-UP DATES START-UP DATE Sept 1986 COUNTRY NAME Saudi Arabia COMPANY NAME LOCATION National Plastic Company (Ibn Hayan) Arabian Petrochemical Company Madiant Al-Jubail Al-Sinahyah Page 64 (Review Date 1 January 1990) TABLE 16 NUMBER OF FACTORIES IN THE WORLD PRODOCTNO pvc So far as known at 1 January 1990 (See Tables 8-15 of this ASL Register) Western Europe USA Canada Eastern Bloc Japan South and Central America Australasia Middle East CLOSED 1 20 1 22 OPEN 53 30 4 23 36 22 3 1 172 V GENC 008322 CQIFIDI1TI1L or cuts or ususucon or the lives <isl) dot to VCR