Document 1QXzZo5azkV3gRLE1p3mg8gLm

kb u5f 3MGeneaem raOffofie July 12, 2000 AR Sai MoPmaol MN 551441000 F71,-0700--(35775761 06] 3 wil SM one pice Chemical Control Division OfficeofPollution Prevention and Toxics United States Environmental Protection Agency 4R0o1omM4S0t3reeEta,stSoTuotwhewres(tMail Code 7405) Washington, D.C. 20460 oni; - er awl) car Re: 3M Fluorochemicals Document Submission -- CD Version Dear Charlie ErenlcaltoesdecdoimsptohuenCdDs tvoerEsPioAnoofvtehrethdeopcausmtefnetwsmsounbtmhist.tedThoins pCeDrfclounotraoioncstatnheesiunlffoornmaatteisoannd dporocvuimdeendttoprtohdeuactgieonncsytboetghiennaignengcwy.ithItnhceluAdperdilwi2t0,h t2h0e0C0Da'nsd iesnadninignfwoirtmhatthieonMsahyeet18o,n20h0o0w 10 access the CD. Several diotecmusmesnhtousladnbdehnoowtebdesbteftooruesyeotuheacsceeasrschthceapdaobciulimteinetss:incorporated onto the. 1. tThheisdoCcDumheanst(asn)ehxet/esnhseivweanitnsd,exansducchlitchkatantdheorpeeandetrhactadnosccurmoellntd.owNnottheetihnatdeesv,efnintdhough the index includes documents opened. as they are not on the submitted CD. after May 18, 2000, those documents cannot be 2. cNoonfciodnefnitdieanltiianlfodromcautimoenntissohnavtehebCeDe.n puDtueontothciosnCcDe.rnsThoveesracnointfiizdeedntviearlsiitoyn, owfeawnyould ask that you confidential refer to the information. paper copies already submitted to EPA when you seck to review 3. TEahcehCsDepacroantteaisnusbtmhiessdioocnumbeegnitnssbwyitshubtmhiescsoivoenrdlaettet,erjuusstedastEo PcoAnvreecyeitvheedinthfeomr.mation to the agency and the indices that accompanied the cover letter 4. sTuhbemiitntfeodrmaastipoanrtporfovouirdceodnttointuheinaggednicsycucsosnitoanisnswiitnhfoErPmaAtiroengatrhdaitn3g Mflvuoolruoncthaermiilsytrhya.s Tsehceusreitdyorceuamseonnstsanadretosudbimsictotuerdagfeorarneyadf-oornmloyfptuarmppoesresinagndwiatrhe not the to be modified. documents, 3M For will be tmhaeinCtDa.iniInngtaermmassotferaCnyDdiasncdreorpiagnicniaelspbaeptewreceonpitehse opfatphere csoapmieesdaoncdumtehnetdsocthuamteanptpseaornon the CD, the information contained in the 3M paper copies is considered to be controlling, 5 8 23 SEa p = =5 WRENN FYI-80-00) 1378 85000000030 000001 2000 a Dr. Charles Auer 1 ` Page2 `We hope that this form of the information assists the agency in the review of thedocuments. Please do not hesitate to contact me at 651-733-6374 should you have any questions. Very truly yours, ober)(2 HH gprant William A. Weppner, Ph.D. aDnidreRcetogruloaftEonrvyiArfofnamiernstal, Health, Specialty Materials Markets 3M Bldg 236-1B-10 3M Center Enclosures ESt:.maPialu:l,wMaiwnenpepsnoetar@m55m1m4c4om Safety i| 000002 3M Fluorochemical EPA Submission CD , QAudiocbkeRAecfreorbeantceReGaudiedre OpeninPglaCcDe:CD in CD-ROM drive. The CD will acivte by itself and will open the following dialog window: eEreme Se ee sh --a AalR galSel a ER ER panty S Se Ee ee ma aT If your computer does not contain Adobe Acrobat Reader then click on the Install Aw`AicflrtloerabpaipntesatRarelsaladteirontaibs caonmdplfeotlleotwhtehnecilnisctkruocntiotnhse.Ru tab. The following Notice NOTICE: | eTmhneiiannfgormeaottitopn eperovt.ided ttToohtkehe dageocnccoy uncotmntoeainns tinefoorrdmsatwoiotinhsthtatoEnIPyM |i PE EurDpoasesmL andoaE epnroetsoscboenmsodih fied. Famorseecunr srosf sonssapnu defrocdtisre eeoeuCrs.nge | pret mn comet i op ond ! Jr-- ! After reading the notice click on the arrow in the lower right hand corner. This wYiolul atraekereyaoduytoo tsheear3cMh aFnlduonraovcihgeamtiectahlrEouPgAh hSuebmdioscsuimoennstsindex. At this point 000003 Opening a Document: . The documents on the CD arepdf (portable document format) image files. The titles of the documents in the index are hotlinks to thepdffile that contains that document. These hotlinks work the same way as hotlinks on the internet. When `your curser becomes a hand pointing the index finger then you are on a link. Simply click your left mouse button and the link will take you to the first page of the document. Navigating Through the Documents: NPreexvtioPuasgePage Last Page of Document GFiorsttoPPaaggee.of Document Go Forward a Document CCuirrl++ PPaaggee DUopwn Ctrl+ Shift + Page Down CCutll ++ NShift + Page Up Crl + Shift + Right Arrow Go Back a Document Curl + Shift + Left Arrow Searching the Documents: Once the main document is open in Acrobat, you will need to connect to the document collection index to activate the advanced searching features. To do this, press Ctrl+ Shift + X all at the same time on your keyboard. Or you can pull down the Edit menu, select Search and then select Search Indexes: Re gTy T ie DOE. SE An" n mo---- x iia Sill Swea | 39 Foroche--mical EPA Submisions _ a T " I TE an op Cu cx nsoswy e eogd ta einata fceyeud coins EF a mun tus LAE RENN oF En 1 TrC3e0A R A0a08TLoo]FAC TT15LXtt :N i st] TYrosarSomeniiten] Gyan emcento [Re ost a Mysto mune] 0135m 000004 This will open the Index Selection dialog window. Click on Add. ok a Pass c`lThiicsk woinllOopepne.n the Add Indexdialog window. Click on the mmm. pdx file. Then set [is [BroSlolalEm iBnen Teidion[oR 3 cys Tinhitshewiblolx.takCeliycokuobnaOckKtoantdheyIonudecxanSebleegcitniosneawricnhdionwg.. MMM should now appear STeoarstcahrtdiaasleoagrcbhoxquery press Ctrl + Shift + F on keyboard. This will open the. Erde Carter Tot T Opti F ModSemniy I Thsons | Sombie Searching ne i rex ~ ca Indes... I Macho I Boiny -- ~ 000005 `Type the text you want to "The text you type search for in can be a in the single Find Results Containing word, a number, a term, Text box: or a phrase. NYOouT)cainn utshee tweixltd-bocra.rd Bcehacraaucsteerosf(t*h,?i),,yaonud mBuosotleeanncloopseeraatnoyrsse(aArcNhD,erOmR, that includes and, or, or not in quotes, Select STeahrechd.ocuments that match your search query will be listed in the Search aRersullitsstedwifnirdsotwo.n tDhoeclustm.ents more likely to contain relevant information Double-click a document that seems likely to contain the relevant information. "yTohue odpoecnumaednotcwuimlelnotpeinn tohne tlhste,fyirostu mvaitecwhofnolrytphaegteesxtcoynotuaitynpiendg. maWtchheens. `All the matches on a page are highlighted. oB3l 2e0 raven esr MY 5 |@5-4-2000,Protocol for Study LowLever PFOSDose vers E= RE ?=i feeaT Short Cut Keys for Searches: Next hit within document Previous hit FPirresvtihoiutsinhitneixntldasotcduomceunmtent CCuull++:+ ReZdouocmeiniomnagiemage. Cul +] Ctrl +[ CCterll ++ SShhiifftt ++ { 000006 CD No. 1 3M Fluorochemical EPA Submissions April 20,2000 [ Cover Letter to EPA Protocol 418-008 Combined oral (gavage) ferity, developmental and || pNoe.r:ina6t2a95l./9p)o,stnTaatballereEp2r0o,du1c-t3ion toxicity study of BFOS in rats (Sponsor's study | Preventionoffluvastatin induced toxicity, mortality, and cardiac myopathy in pregnant ras by mevalonic acid supplementation. "The mechanism underlying the hyperlipemic effectofperfluoroocanoic acid | PFOA). perfluorooctane sulphonic acid (PFO) and clofibric acid. Developmental changes in the expressionof genes involved in cholesterol | biosynthesis and lipid transport in human and rat fetal and neonatal livers. f Final ReportProtocol 418-013 Oral (Gavage) Pharmacokinetic Recovery Study of PFOS in Rats (Sponsor's study No. T-6295.12) Protocol FACT-TOX-110 Oral (Gavage) Pharmacokinetic Studyof PFOS in Rats. Protocol PFiFnOalSRienpoRrattsPr(oStpoocnoslor4'1s8s-t0u1dy5 ONroa.lT(-G6a2v9a5g.e1)4)Pharmacokinetic Recovery Study of Protocol FACT-TOX-I11 Oral (Gavage) Pharmacokinetic Recovery Study of I `PSFuOmSmairnyRaPtFs,OSPrRoatotcTolwo-Generation Reproduction Study ( Study No. 3M T6295.9, Argus 418-008 [n-life], FACT-TOX-012 [analytical] Report Amendment I, 13,Protocol 418-008 (Sponsor's study No.: 6295.9) | CReopmrboidnuecdtiOornaTlox(iGciatvyageS)tuFdeyrtoilfitPy,FODSeveilnoRpamtse,ntFailnaalnRdepPoerrtinata/l Postnatal | `Analytical Lab Report on the Determination ofthe Presence and Concentration of | Potassium Perfluorooctanesulfonate (CAS No.: 2759-39-3) in the Serum and | <LiUv2e0ro06f>S,pRreaqguuees-tDoarwlPreoyjeRcattsNoE.xp<o3sMedTtOoXPF6O29S5v.i9a>Gavage, Lab Report No. | Tnteroffice Memo from Tom Kestetro Leo Gehlhoff, "Fluorochemical Tsomer | FDiinsatlriRbuetpioorntPbyrot!o9coFl-4N1M8R-0Sp0e8ctCroomsbciopned Oral (Gavage) Fertility, Developmental | and Perinata/l Postnatal Reproduction Toxicity StudyofPFOS in Rats (Sponsor's s`StuumdmyaryNo. 6P29O5.S9)Rat Cross-Fostering (Study No: 3M 1-6295.13, Argus 418-014) Final ReportProtocol 418-012, Oral (Gavage) Cross-Fostering Study of PFOS in R`Aantasl(yStpiocnalsoLra'bssRteupdoyrtNoon.:thTe-6De2t9e5r.m1i3nationofthePresenceand Concentration of | | Perfluorooctanesulfonate (PFOS) (CAS No. 2759-39-3) in the Serum of Sprague| Dawley Rats Exposed to Potassium Perfluorooctanesulfonate via Gavage, Lab. | Report No. U2779, RequestorProject No. 3M Tox 6295.13 Paget 000007 3M Fluorochemical EPA Submissions `Cover Letter 0 EPA in Rats aftea Single IntravenousDose of FC 95 14.C `Cholestyramine-Enhanced Fecal EliminationofCarbon 14 i Rats afer Administration of Ammonium [14 C] Perfluorooctanoate or Potassium 14] Perfluorooctanesulfonte Environmental Lab Study No. AMDT-042095.1 3M Environmental Lab Study No. AMDT020895.1 3M Environmental Lab Study No. AMDT-112294.1 No. 154-160 i reviewing draft Rat Teratology Study T-3351 | `Oral Teratology Studyof FC-95 in Rats, Riker Lab, Experiment No. | 068TRO00S rLeetvtieerwitnogFrtahnekOlrianlDT.erGartioiltohgy, PSht.uDd.y forfomFCM-a9r5shianlRlaJtoshnson, Ph.D. Study No. 418-012 Argus Labs `MedicalSurveillance and Epidemiology `Final R"eApnorEtpsidemiologic Investigation of Clinical Chemistries, Hematoloagndy Hormones in Relation to Serum Levels of Pernfplluooyreoeosctanesulfonate in Male Fluorochemical Production Chemistry Tests in Fluorochemical Production Employees Chemical and Film Plant Employees `Mortality Study of Employees at 3M Plant in Decatur, Alabama `DeterminationofSerum Fluorochemical Levels in Sumitomo 3M | Employees Carboxylic Fluorochemicals Page 000008 3M Fluorochemical EPA Submissions and Clue II (1989) epidemiologic investigations. "An Epidemiologic Analysis ofthe Inpatient and Outpatient Claims Event and Episode Experienceof 3M Decatur Employees, 1993-1998 Determination of Serum Elimination half-lives ofAmmonium Perfluorooctanoate, Perfluorooctane Sulfonic Acid, Perfluorohexane SReutlifroeneisc Acid and Total Organic Fluorine in Decatur Chemical Plant Pporsottnoactoall4r1e8p-r0od0u8cCtioomnbtionxeicditoyrasltu(dgyaovafgeP)FOfeSrtiilnitrya,tdse(vSeploonpsmoern'tsaNlo.and62p9e5r.i9na)t,al Table E20, 1-3 pregnant rats by mevalonic acid supplementation. "The mechanism underlying the hyperlipemic effectof perfluorooctanoic acid D(ePvFeOlAo)p.mepnertfalluocrhoaoncgtaetseisnutlhpehoenxipcreascsiidon(PoFfOSg)eneasndincveollofviebdriicn acchiodl.esterol biosynthesis and lipid transport in human and rat fetal and neonatal livers. Tnteroffice memo from Tom Kester to Leo Gehlho, "Fluorochemical [somer Distribution by |9F-NMR Spectroscopy" Voluntary Use and Exposure Information Profile - Perfluorooctane Sulfonic Acid and Is Salt Forms [Myazos Determinationofthe Vapor Pressureof PFOS Using the Spinning Rotor GPaFOuSg:e MDeettehromdinationofthe n-Octanol /Water Partition Coefficient by the. Shake Flask Method ~ A Non-GLP Feasibility Study in Support of Wildlife Intl Ld Project No. 454C-108 Page 000009 3M Fluorochemical EPA Submissions Method EnvironmenFtaatle and Transport "Adsorption of FC-95 and FC-143 on Soil /Summaryof the Soil Adsorption study ofthe Potassium Salt of Perfluorooctanesulfonic acid FC-95/ Photolysis Study Using Simulated Sunlight / Summary of Photolysis Study Using Simulated Sunlight on the Potassium Salt of Perfluorooctanesulfonic acid `Biodegradation Studies of Fluorocarbons (8/12/76) report and Biodegradation Studies of Fluorocarbons ~ Il (7/19/78) report "Transport between environmental compartments (Fugacity modeling) / letter from Don Mackay on the air/ water partitioning coefficient calculations "Analysis for flsorochemicals in Bluegill ish Ecotoxicity Elements I PFOS: A 96 --Hour Static Acute Toxicity Test with the Fathead Minnow I| PPFiOmeS:phaAle9s6-pHroomuerlaTso)xicity Test with the Freshwater Alga (Selenastrum | capricomutum) I P(FDaOpSh:niAa m4a8g-rHour Static Acute Toxicity Test with the Cladoceran PFOS: A 96-Hour Shell Deposition Test with the Easter Oyster l (Crassostrea virginica) PFOS:A 96-Hour Static Acute Toxicity Test with the Freshwater Mussel | (Unio complamatus) PFOS : An Activated Sludge, Respiration Inhibition Test [FOS AD Hour Sn Ate "Toxicity Test with the Saltwater Mysid (Mysidopsis bahia PFOS:An Early Life-Siage Toxicity Test with the Fathead Minnow (Pimephales promelas) (Daphnia magn Mysid (Mysidopsis bahia) Pages 000010 3M Fluorochemical EPA Submissions "HTahtechEaffbeicltisoyoffECogngtsinaunodusGrAoqwutehouasndExSpurovsiuvraelotfoF14Co-r f78F.a0t2y hoenad Minnow (FPaitmheepahdaMliesnnporowme(lPaisme/ pShualmemsarpryoomeflhaiss)toEpxapthoosleodgitcoa7l8E.0x2amfoirn3a0tDiaooynssf EffectofPotassium reproduction) Perfluorooctanesulfonate on Survival, etc. (Daphnid Pimephales promelas 96-hour FC-94-X (Li salt of PFOS) Toxicity Test Data Summary. Sample ~ 38-HR PFOS Acute Toxicity toDaphnia, Daphnia magna, FC-04-X (Li salt of ) `EMviaclruoabtiicosnMoifcFrCot-o9x4-ToXxicbiytyOETCesDt.AcStaimvaptleed SFlCu-dg9e4-RXes(pLiirastalitonofPInFhiObSit]ion Test #209, FC-94-X. tResetvdiaetwaosfheOetEsC(DLi 2sa0l9t oafndPFBOOS)D/COD Test Results for `P9E6O-HSour Acute Toxicity Test on Bluegill Sunfish (FC-99, DEA salt of [SummaryFRineapl oCromtpsrehensive Report: FC-93 | EnvironDmeesnigtnalaMnodniSttrourcitnugreo~fPaMrultt1-C:itMyult-SCtiutdy Study 1 GFlAuor(oWc2h3e3m6i)cal Characterization of Drinking Water Samples. Columbus, FElLuo(rWo2c1h7e6m)ical CharacterizationofDrinking Water Samples. Pensacola, | FLulcuioer,ocFhLemica(Wl23C63h)aracterizationof Drinking Water Samples, PortSL | Fluorochemical Characterization of Drinking Water Samples. Decatur, Alabama (W1979 FAlluaobraomcahem(iWc2a1l51CharacteriofzDartinikoinng Water Samples. Mobile, `TFelnunoersosceheemica(lW1C97h3 aracteroifzDaritnikionng Water Samples. Cleveland. Battelle Field Sampling Procedures Review. Columbus Georgia Cy Survey regarding Empirical Human Exposure Assessment. Multi-City Stud `Muli-City Study. Field Report for Cleveland Tennesse and Decatur Alabama ~ Battelle Duxbury Activities Multi-City Study. Field Report for Columbus Georgia and Port SU Lucie Florid~a Battelle Duxbury Activities Pages 000011 3M Fluorochemical EPA Submissions Florida -- Battelle Duxbury Activities i `Amendment 1 to the Quality Assurance Project Plan and Associated SOP's Perfluorinated Compounds in Environmental Samples" `An Acute Inhalation Toxicity Studyof T-2306 CoC in the Rat, Bio/dynamics, Project No. 78-7185 (FC-95, Perfluorooctane Acute Oral Toxicity (LD50) Study in Rats with Fluorad Fluorochemical Surfactant FC-95, Intl R&D Corp, Project No. Combined Eye and Skin Irritation Studies Report on Sample T- 1 1166 (FC-98), Warf Inst, Project No. 5011023. `Eye Irritation Study (with washout procedure) Report on Sample T-1166 (FC-98), Warf Inst, Project No. 5011023. C T T emmgen T) Mutagenicity Evaluation of T-2014 CoC in the Ames Salmonell/a Microsome Plate Test Final Report, Litton Bionetics Project No. Memo Report from SR. Rohfing to A.N. Welter, on Resultsofthe Ames Spot Test for Mutagenicity screeningofvarious FCs, including Sample 23-583 which is FC-95, Notebook Reference `Mutagenicity Test on T-6295 in an in vivo Mouse Micronucleus Assay, Final Report, Coming Hazleton, CHI Study No. Final Report, Chromosomal Aberrations in Human Whole Blood Lymphocytes with PFOS, Covance Lab, Covance Study No. 20784-0-449, 3M Reference No. T-6295.18 / October 25, 1999. Cell Cultures with PFOS, Covance Lab, Covance Study No. =Final Report, Salmonella Escherichia coli / Mammalian- Microsome Reverse Mutation Assay with PFOS, Covance Lab, Covance Study No. 20784-0409, Reference No. T-6295.17, and = oo00)[ar 3M Fluorochemical EPA Submissions Final Report, In Vitro Microbiological Mutagenicity Assays of 3M Company Compounds T-2247 CoC and T-2248 CoC, SRI Intl, SRI Project No. LSC-4442-016, 3M Reference No. T-2247.1 (FC-99 `Evaluationof Mutagenicity Studies Developed on (PFOS) Perfluorooctane Sulfonate Final Report - Bacterial Reverse Mutation Assayof 1-1, Hita Research La/b Study Code K01-1802, 3M Reference No. T- Rep I-Dose Toxici Ninety-Day Subacute Rhesus Monkey Toxicity Study, with Toxicity Study, with Fluorad Fluorochemical Surfactant FC-95, Intl R&D Corp, Project No. 137-087 Ninety-Day Subacute Rat Toxicity Study, with Fluorad Fluorochemical Surfactant FC-95, Intl R&D Corp, Project No. PerfluorooctaneSulfonic Acid Potassium Salt (PFOS: T-6295) in Rats, Covance Lab, Study No. 6329-183. Summary Report -- Week 53 undated } "Liver Slide Review", MarvinCaseto John Butenhoff and Andrew Seacat relaying the resultsofan independent histopathologic reviewofliver slides from the study `Study Reportof Determinationof Cyanide Insensitive Palmitoyl-CoA oxidation in samples from 3M 212, Study No. XRO108 "Rangefinder: 4-Week Capsule Toxicity Study with PerfluorooctaneSulfonic Acid Potassium Salt (PFOS: T-6295) in rE `Unaudited Draft Final Report, 4-Week Capsule Toxicity Study with Perfluorooctane Sulfonic Acid Potassium Salt "Cell Proliferation Report, d-Week Capsule Toxicity Study | T-6295) in Cynomolgus Monkeys, Covance Labs, Study | No. 6329-222 (draft to be incorporated in final report) l 000012 --- | 3M re Fluorochemical EPA Submissions Perfluorooctane Sulfonic Acid Potassium Salt (PFOS; TLab, AMDT-041598.1 oy "26-Week Capsule Toxicity Study with Perfluoroociane Sulfonic Acid Potassium Salt (PFOS: T-6295) in Cynomolgus Monkeys, Fecal Urbilinogen Analysis, Mayo Clinic, Test Code: 8308. General Info from Mayo Clinic on Urobilinogen Analysis Individual animal urobilinogen 1ab reports from Study No. EM99.76 Pathology Review, Marv Case to Andrew Seacat, relaying | the resultsof a histopathology reviewofslides. | Lab Report, Interim Report of Preliminary Data for 26 Cynomolgus Monkeys, 3M Environmental Lab, Report No. Two Week Oral Rangefinding Toxicity Study of T- Experiment No. 179RR023, 3M Reference No. T-2509.3 (FC-99 New Formula, L-4509, 25% diethanolamine salt of `Skin Absorption Studies on Surfactants Report from W.C. McCormick to D.R. Ricker `Skin Absorption Studies on Surfactants 28 Day Evaluation Lab, Riker Labs, Experiment No. 0979AB0632 (FC-95) `Skin Absorption Studies on Surfactants 28 Day Percutaneous Absorption Study in Rabbits with FC-99, Safety Evaluation Lab, Riker Labs, Experiment No. 0979AB0633, 3M Reference No. T-3988.1 000013 3M Fluorochemical EPA Submissions Single-Dose Intravenous Pharmacokinetic Study of1-6033 in Rabbits, 3M Environmental Lab. Final Report - Analytical Study, NHoaz.lTe-t6o0n53W.i1sconsin Project No. HWI 6329-136, 3M Reference RSaibnbgiltes-,Do3sMe EDnevrimraolnmAebnstoarlptLiaobn,/STtouxdiyciNtoy.SAtMudDyT-of02T2-6109553.1in Final Report - Analytical Study, Hazleton Wisconsin, Project No. HWI 6329-137. 3M Reference No. T-6053.2 Fluorochemical (FC) Levels in Naive Rats, 3M Medical DDreapfatrtRmeepnotr,tTfooxriOcbojleoctgiyvSee3rvices, Study No. T-6316.9, DT21. "dAantaeldytMicaayl D3,at2a00s0u,bimnictleudditnogDsre.rJuemnnmiefaesruSreeemde,nUtsSEfPrAo,m btwyoleitnt-er life studies "Analytical data from Advanced Bioanalytical Services Study No. FACT-TOX-111, re: Oral (Gavage) Pharmacokinetic Recovery StudyofPerfluorooctane SRuelffeorneantceeiTn-R6a2t9s5,.A1r4gus Labs Protocol No. 418-015, 3M. `Analytical data from Advanced Bioanalytical Services PShtaurdmyaNcoo.kiFnAeCtiTc-TSOtXud-y1o1f0P.e,rfrel:uoOrroaloc(tGaanveaSguel)fonate in || R6a2t9s5,.1A2.rgus Labs Protocol No. 418-013, 3M Reference T- Tn Vitro Comparative Metabolism Study in Rat and Human Hepatocytes with Various Fluorochemicals, 3M Reference T- 6295.1, study of T-6292, T-6293, T-6294, and T-6295. Range-finding Cytotoxicity Assay, SRI Intl Toxicology Lab, Study No. B010-95 `Metabolismof T-6292, T-6293, T-6294, 1-6295 by Rat and Human Hepatocytes, SRI Intl Toxicology Lab, Study No. BO11.95 "AAdddivtainocneadlBCihoaarnaacltyetriiczaaltSieornvoifceMse,tAanbaollyittiecsaolfRTe-po6r2t9,2, T- 6293 and T-6294 from Rat and Human Hepatocytes by TurbolonSpray LC/MS and LCMS/MS. Semi- Quantitative Hepatocytes AnalysisofT-6295 in Rat and Human Incubated with T-6292, T-6293 and T-6294 by | LC/MS/MS, Report 98AGKPOL3M. `PeWrofrlkuionrgoIsnutlefropnreatmaitdieonMoeftaRbesoullitssm, cihnaRratttivst.ledHuman Page 000014 3M Fluorochemical EPA Submissions [CC Mecham`iOsneteGeneration Reproduction Study of PFOS ~ Mevalonic Acid / 1] Cholesterol Challenge and NOEL Investigation in Rats. Draft Study Outline Pharmacokinetic Analysis. Study Outline Pharmacokinetic Analysis. Study Outline Biochemical and Molecular Mechanistic Studies of N-ATKyT Perfluorosulfonamides, Research Proposal, Kendall B. Wallace "The Effectof Perfluorinated Arylalkylsulfonamides on Bioenergetics of Rat Liver Mitochondria, Kendall B. Wallace and Anatoli Starkov Report on Covance Studies, assessment of mitochondrial biSoeenemrgeatiocfs i 1 PEC on Maca Baerga: || In Vitro EffectsofSelected Perfluoro-compounds on Mitochondrial Beta- Oxidation Effect of Acute FC Administration on Catalase and acyICoA I ODniisdpalasceeEmxepnrteossfaioFnluorescenlly Labeled Fatty Acid Analogue from Fatty Acid Carrier Proteins by Wyeth -- 14,643, Ammonium Perfluorooctanotate, Potassium Perfluorooctane Sulfonate and | Other Known Peroxisome Proliferators, Nabbefeld, et al. Pilot Teratology Study in Rats, T-3551 Final Report, 3M 1 Reference T-3551.12 | HumanSera/Medical Surveillance Epidemiology 1 Memo from D.E. Roach and S.D. Sorenson, Decatur Blood Fluoride Review "Antwerp Blood Testing Results ] "AnalysisofSerum Values in Decatur Workers ] Lab Report, Analysis of FCs in SamplesofChildren's Sera, Lab 1 "RLeapboCrotmNpoo.siFtAeCTRe-pGoErtN,-A0n1al1y,t3icMalEnRevpiorrotnsmeonftDaaltLaafbor Fluorochemical Analysis in Human Ser, LIS No. 1623, 3M Environmental Lab "Abiotic Degradation Studies. Includes Hydrolysis and Photolysis SBtiuoddyegPrlaadnastion Studies (Includes Studies on : serobic acclimated bciloodseegdrbaodtattlieobni,opduergreacdualttiuorne,aaeerroobbiicc, asonidl/flsueodriomcehnetmical | decomposition process) Page 10 000015 EPA Submission Draft Protocol: POS: A96-Flour Toxicity Test with the Freshwater Alga `Protocol: PFOS: A 96-Flour Toxicity Test with the Freshwater Distom Protocol: PFOS: A 96-Hour Toxicity Test with the Marine Diatom. Protocol: PFOS: A 7-Day Toxicity Test with Duckweed Perfluorooctane Sulfonate Studies Ongoing Research/Study Protocols Protocol for Stud:y Low Level PFOS Dose versus Rat Serum and Liver PFOS, 3M Medical Department, Toxicology, Study No. T-6295.16 DT31 Protocol for Study: Pharmacokinetic StudyofPOSF in Rats, 3M Medical Department, Toxicology. Protocol for Study No. T-7098.1 "Pre-197D6atEanvfirroomnmFeantthaeladSMtuidnineoswOnStPuedryfolnuoFrCo-oc9t3an(e2s3u%lfNonHatessalt of PFOS in IPA and water), 3M Environmental Lab, Aug. 2, 1974 Data from Fathead Minnow Study on FC-03 (25% NHA saltofPFOS in IPA and water). 3M Environmental Lab, Oct. 19, 1974. `BOD/ COD results for FC-93 (25% NH salt of PFOS in [PA and water), 3M Environmental Lab, July 18. 1974 [Mayirzoeo `Cover Letter to EPA / additional information relating to perfluorooctylsulfonate 7] (PFOS) salts May 12, 2000 I `Cover Letter to EPA from Julia Hatcher (Latham & Watkins) "Composite Analytical Lab Report on the Quantitative Analysis of Fluorochemicals in Environmental Samples | Mayis2000 1] `PoStuamsmsairuym"S2a6lt-(WPeFeOkSC)apisnuClyenToomxoilcgituys SMtoundkyewyist,h CPuerrrfelnutorSouocmtmaanersyulafsoonficMAacyid4. 2000 `Cover Letter to the resubmittalofconfidential information previously submitted onMay 4. N-EFOSE Alcohol Bibliography "Phys/Cihecmiacall Properties Water Solubli Page 11 000016 3M Fluorochemical EPA Submissions TenerReport Boling Porm Information EtFOSE) Tweocrhk R-eBpOoDrI-tCOBiDo,coMnecemnora-tTioencohfReFpMo3r4t22 in Bluegill Suni and EChvanenenl Catfish. Tech Report - Aquatic Fat ofa Fuorochemical RTeepcohrtRepFolrort--ocBhieomamciccuamluslaitniToennnoefsFsleueorRoicvheermiFciha.ls in Tenn. River. Tech TEghgesEaffnedctGsroofwtCohnntidnuSouursviAvqalueoofuFsryExopfFoastuhreeatdo 7M8in0n1owo.n FSarucmhmaabriylyofof 3Hi0sDtoapyasi.hological Examinationsof Fathead Minnow Exposed 10 78.01 or Phys/ i Chc emiacall Properties Tech Report -- Biodegradation Studies on FM-3925. Tech Report -- 1 Chemical Oxygen Demand of FM-3925 T"Teecchh RReeppoortrtFBliucoarcotchuemmuilcaailosnoinfTleoanr.ocRhievmeircFaislhs, TAnfTNoom.n2R3i8ver Fok, Determination of Fluorinated Alcohols in Fish Extracts rae 12 000017 3M Fluorochemical EPA Submissions Tech Report -- Bioaccumulation of Fluorochemicals in Tenn. River Fish. Tech Report -- Fluorochemicals in Tenn. River Fish | poss] PTorxiimcaorlyogSyk,iRiTkreartiLaobns,TePsrtojweictthNTo3.9(73486TEnBAOl1o3i5n,o R3aMbReef,erPeantcheolNoog.y and T-3874 TPr-o3j6e0c7t NAoc.ut4e7-I5n2h7a,la3tiMonRTeofxeirceintcyeTeNsot., TB3u6sh0y7Run Research Center, I er "`AAcpupteendOirsa,lHTaozxliectitoyn SLtabusd.y P--roMjeetchtoNdo,.S4u0m7m0ar3y9,3Pathology and Raw Data In Vitro Microbiological Assays of 3M Company Compounds T-2540 CNoo.CTa-n25d8T1-.21541 CoC, SRI Intl, Project No. LSC 4442-16, 3M Reference 7 `Protocol, Pharmacokinetic StudyofPOSF in Rats, 3M Strategic Toxicology Lab, 3M Reference No. T-7098.1 "AcuteOral Toxicity Screen with T-3421inAlbino Rats, Safety Evaluation Lab, Riker Labs, Project No. 0883AR0287, 3M Reference No. T-3421 "Acute Ocular Irritation Test with T-3421 in Albino Rats, Safety Evaluation Lab, Riker Labs, Project No. 0883EB286, 3M Reference No. T-3421 [ 000018 3M Fluorochemical EPA Submissions Primary Skin Irritation Evaluation Lab, Riker Test Labs, wPirtohjeTc-t3N4o2.1 0i8n 8A3lAbRi0no28R8a,bbi3tMs, RSeaffeerteynce No. [SuTad al esinbroges| Protocol, Feces Method Development Metabolism Study for Perfluorooctanesulfonate Derivatives, 3M Strategic Toxicology Lab, Study Nos. T-636.17; T-6295.21; T-7132.3; ST-41 Protocol, Pharmacokinetic StudyofPerfluorooctane Sulfonamide in Rats, 3M Strategic Toxicology Lab, Study Nos. T132.2; ST-39 Protocol, Cell Proliferation Study with N-Ethyl PPeortfalsusoiruomocStlatn,easnudlfNo-nEaimhiyd!o Eetrhlaunoorl,ooPsearnflcusourlofooctnaanmeiSduelfnonRiactA,cid I Pathology Associates Intl, -- Study No. 1132-100 | ARecfuetreeOnrcaelNToo.xiTc1it9y8--3 Ra(tFsC,.1B2i8osearch, Project No. 77-1108A, 3M Acute Oral Toxicity ~ Rats, Biosearch, Project No. 77-1127A, 3M RPerfiemraernycEeyNeo.TaTt-2i0o0n1 St(FuCd-y12-8)Rabbi, Bosearch. Project No. T7-TTI7A, 3M Reference No. T-2001 (FC-128) Primary Skin Irritation Study -- Rabbits, Biosearch, Project No. 77-1127A, 3M Reference No. T-2001 (FC-128) [Gemowei`BAinyAocutdeynaImnichsa,laPrtoijoencTtoNxoic.i7t6y.S71t8u6d,yo5fMT-R2e3f0e7reCncoeCNion. tThe23Ra0t7, (FC-128 Bacterial Reverse Maaton Testov-1, Fa Research ab, Chemicals | Inspection and Testing Institute, Study Code: K01-1815, Report No. T-4663, 3M Reference No. T-6668.1, FC-129 In Vitro Microbiological Mutagenicity Assays of 3M Company's. Compound T-3290 CoC, SRI Intl, Project No. 3145, 3M Reference No. T-3290 28 Dermal Percutaneous Absorption Study with FC-128 in Albino Rabbits, Safety Evaluation Lab, Riker Labs, Project No. 0979AB0629, 3M Reference No. T-3991 28 Day Dermal Percutaneous Absorption Study with FC-129 in Albino RRaebfbeirtesn,cSeaNfoet.yTE3v9al8u9ation Lab, Riker Labs, Project No. 0979AB0627, 3M Final Report -- Analytical Study: Single-Dose Dermal Absorption / STStouMxdiRcyietfNyeo.rSetAnucDdeMyoTNfo-s0T.1-T366015091551.ai1ndnidnT-vT6i60v0o543S4iundRyabRbeiftusr,e3ncMe No.EnviroWnImen6t3a2l9-L1a3b3,, || ets 000019 3M Fluorochemical EPA Submissions Final Report, Analytical Report and Single-Dose Intravenous Technology & Services, In-Vivo Study Reference No, HWI#6329-138, [SudiesinProgress | es [AoweToxiciy| Reference No. T-4102, Samples No. T837389-410 754. Final Report, Acute Oral Toxicity Study in Rats, Hazelton Labs, 3M Reference No. T-4102, Sample No. T837389-410 754 Final Report, Primary Eye Irritation / Corrosion Study in Rabbits, Hazelton Labs, 3M Reference No. T-4102, Sample No. T837389-410 754 [Gemotoxiciy __________________________] Mammalian-Microsome Reverse Mutation Assay, Coming Hazleton, Corning Hazleton, Project No. 17387-0-409, 3M Reference No. T-6357, | FC-120 J I Single-Dose Dermal Intravenous Pharmacokinetic Study of T-6052 in' | { Rabbits, Hazleton. Project No. HWI 6329-134, 3M Reference No. T-6052 N-EtFOSA [AcueTodey| Final Report, Acute Ocular Irritation Test with T-3608 in Albino Rats, Riker Labs, 3M Reference FX-12, Study No. 0984EB0367 HERats, Riker Labs, 3M Reference No. FX-12, Study No. 0981AR0146 Fininaanl Report, In Vivo PMrooutsoceolMiacnrdontuwcolaeumsenAdsmseanyt,sC,orMnuitnaggeHnaizceilttyonT,esSttoundyTN-o6.294 000020 EPA Submission Draft [MT.Je . Cross ac nd RG. Sh chnellmaa nn, Mechn anism ofi Toxicityc of a Uniq] ue `PmeesttaibcoildieteN-pEetrhfyllupoerrofolcutoarneooScutlafnoenSaumlifdaeno(mPiFdOeS)(NtEoPIFsoOlSa)t,edaRnadbbitist Renal Cortical Mitochondria, Abstract from 1989 Societyof Toxicology deaAnalytical and Research Properties -- 3M Industrial Hygiene Lab [_~MeFosa [doweTosicip 7] Primary Dermal Irritation ~ Method, Summary, Pathology QAU Report, Summary; QAU Report; Raw Data Appendix, Hazleton Labs. Project No. "Acute Oral Toxicity Screen with T-3065CoC in Albino Rats, Riker Labs, [Gemotoxiciy| No. LSC-3145, 3M Reference No. T-3752 No. LSC-3145, 3M Reference No. T-3727 yeN-EtFOSEAlcohol [AcwteToxiciy| Reference No. T-299911T, Hazelton Labs, Study No. 154-157 Micronucleus Assay, Hazelton, Study No. 15516-0-454 Final Report, Genotoxicity Test on T-5710.1 in the In Vivo / In Vitro H`FaiznealltoRne,porStt,udMyutNaog.en1i5c5i1t6y-T0e-s4t9o4n T-6202 in an In Vivo Mouse Ey Cell Gene Mutation Test with LS178Y Mouse Lymphoma Cells, NOTOX Study No. 223458, 3M Reference No. FC-3923 Final Repo! Repeated-Dose Toxi R&DCorp, Study No. 137-086 i 000021 3M Fluorochemical EPA Submissions FFiMn-a3l4R2e2p,orni,lNRin&etDyCDoaryp.SSutbuadcyutNeo.Rh1e3s7u-s0M88onkey Toxicity Sdy, on Report, Volumes 1-5, Two Year Oral (Die) Toxicity / Carcinogenicity StudyofFluorochemical FC-3924 in Rats, Riker Labs, Study No. 0281CRO0I2 Report Amendment No. 1, Two Year Oral (Diet) Toxicit/y CSaturdcyinoNgoe.ni0c2i8t1yCSRt0u0dy12of Fluorochemical FM-3924 in Rats, Riker Labs, LXeetntoesr oLfetDteercedmabteedrM1a0,y12949,01[9r9e:1 2wyieharatctaancchemresnttu:dy3),MFRoeosdpoAndsdeit(i0veFDA Peition Nos. 0B4197 and 0B4206 FM-3924 in Rats, Pathology Associates Intl [ Amlyt Revc iewa by Dlr. Woillinam r H. Be utlem r ofiTwonYeaer (d Diets ) Toxaicim ty ple| CSaurcmimnoagrenyicRityepSotfuodWyreeotfkFl5u3,or1o0ch4e-mWceieakl FM-3924 in Rats Dietary Carcinogenicity Say Rwaittsh,N3aMrrRoewfeRraenngcee NN-o.EthTy-l63P1e6r.f1l.uCoorovoacntcaeneLsaublsf,a6no3a2m9i-d2o12Etahnadno-l2i2n8 Synthesis and Final Report, Characterizationof N-Ethyl FOSE Absorption and Biotransformation 4C. of N-E Riker Labs thyl FOSE and | `Tissue Distribution and Eliminationof Carbon-14 after Administration of | N-Ethyl FOSE-14C in Feed. Riker Labs [ | fechanFiisnaileReport, Analysisof1-587 in a Cell Proliferation Assay in Rat || 3L9i2v4e,r CLeoltls5,47Ha,zLe-l1t3on2,02S,tuPrdoytoNoc.ol,15K4e-y20t8o,F3CMAlRcefoehroelnTcoexT-S5a8m7p7l,esF,M- || Analytical data By [TeraoloFginyal Repor, Oral (Gavage) Developmental Toxicity Studyof N-EtFOSE| "inSuRamtmsa,r3yMN-REe(fFerOeSnEceRaNot.TeTr-a6t3o1l6o.gy7, Oral (Gavage) Developmental Toxicity Study of N-EWFOSE in Rats, 3M Reference No. T-6316.7 N`S-uEmFmaOrSyENi-nERFabObSitEs,Ra3bMbiRteTfeerraetnocleogNyo,.OTr-a6l3(1S6t.o8mach Tube) Developmental Toxicity StudyofN-EGFOSE in Rabbits, 3M Reference No. T-631638 Final Report, Oral Rangefinder Studyof T-2999CoC in Pregaant Rabbits, SFaifentyal ReEvpaolrutaatnidonPLroatbo,coRli,keOrraLlabTse,raSttuodlyogyNoS.tu0d6yo80fRTB-02091999CoC in Rabbits, Safety Evaluation Lab, Riker Labs, Study No. 0681TB0212, 3M Reference No. FM-3924 Page 17 000022 3M Fluorochemical EPA Submissions DIRM.InRtiecrknealr CaonrdrWesCp.ondMecnCcoerrmeiaclkcohols being used in Riker studies, from ATnRa.lyMtiactahliAsneanl'yosEe.sG.ofGSoursmpeenrsion of FM-3924, Internal Memo, from Evaluation Lab, Riker Labs, Study No. 06S0TRO010 3DRM.InRtiecrknaelr CtoorWr.eCs.poMncdCenocremirecaklcohols being used in Riker studies, from Final Report, Special Lens Oral Teratology Studyof T-2999CoC in Rats, Safety Evaluation Lab, Riker Labs, Study No. 0680TR0020, 3M Reference No. FC-3924 Final Report and Protocol, Special Lens Oral Teratology StudyofT- | 2999CoC in Two Strains of Rats, Safety Evaluation Lab, Riker Labs, 3 S3DtRMud.yinRtiNecomk.ael0r6Ct8oo1rWTreR.s0p3oM6ne2dCeonmcmeickaeahls being used in Riker sade, Form Analytical Analyses of Suspension of FM-3924, Internal Memo, from T.R. Mathisen to E.G. Gortner G3oMrIntteetrrnoalRCMorrPeasypteorndence re analytical analysis of FM-3924, from E.G. Studies`SIuMnmemPamrrooysfroofmDEe.Gv.elLoapmmbernetcshttotoDRaitkeer Study Files re Fetal Lens Artifact -- Protocol, N-EFFOSE Ble Method Development in Rats IM Stegic Toxicology Lab, Study No. T-6316.15; ST-30 Protocol, Feces Method Development Metabolism Study for 1 Perfluorooctanesulfonate Derivatives, 3M Strategic Toxicology Lab, | Study Nos., T-636.17; T-6295.21; T-7132.3; ST-41 | I Protocol, Cell Proliferation Study with N-Ethyl 1 Perfluorooctanesulfonamido Ethanol, Perfluorooctane Sulfonic Acid Potassium Salt, and N-Ethyl Perfluorooctanesulfonamide in Rats, Pathology Associates Intl, Study No. 1132-100 N`Aoc.utTe8O-r1a1l6T1oAxicity - Rats, Biosearch, Inc, 3M Ref. T-2038CoC, Study "TP-r2i0m3ar8yCoECy,e ISrtrudiytatiNoon.St7u8d-y1 1--6R1aAbbits, Biosearch, Inc, 3M Ref. Primary Skin Irritation Study -- Rabbits, Biosearch, Inc., 3M Ref. T2038CoC, Study No. 78-1161A Experiment 0979AR0037 Pages 000023 3M Fluorochemical EPA Submissions DNA Synthesis and Cell Proliferation Assays in Rat Liver Cells, Hazelton, Hazelton, HWA Study No. 15515-0-454 Microsome Test, NoTox Project 115932, NoTox Substance 38187, 3M Evaluation of the Abilityof T-5874 to Induce Chromosome Aberrations in Cultured Peripheral Human Lymphocytes, NoTox Project 115919, NoTox Substance 38187, 3M Reference T-5874.2 Evaluation of the Mutagenic ActivityofT-5874 in an In Vitro Mammalian Project 115921. NoTox Substance 38187, 3M Reference T-5874.3 13-Week Dietary Toxicity Study with N-Methyl | Perfluorooctanesulfonamide Ethanol (N-MeFOSE, T-6314) in Rats, Covance Study No. 6329-225, 3M Reference No. T6314.1 Audited Draft Letter from Andrew M. Seacat to Peter J. Thomford, Study Director at Covance, re errors in draft report. I3-Week Dietary Toxicity Study Analysis ofT-5794 in a Cell Proliferation Assay in Rat Liver Cells, aHnaazleylttiocna,l dFaitnaal Report, HWA Study No. 154-207, and protocol and ! `Analysisof T-5878 in a Cell Proliferation Assay in Rat Liver Cells, Hazelton, Final Report, HWA Study No. 154-209, and protocol and analytical data Acute Oral Toxicity Screen with T-3493 in Albino Rats, Safety Evaluation Lab, Rik Primary er Sk iLnabIsr,riPtartoijoencTteNsot.wi0t8h84T-A3R4090310i,n A3lMbiRneofReartesn,cSeaNfoet.yT-3943 Evaluation Lab,Riker Labs, Project No. 0884EB0009, 3M Reference No. Acute Ocular Irritation Test with 1-3493 in Albino Rabbits, Safety Evaluation Lab, Riker Labs, Project No. 0884EB0008, 3M Reference No. T-3943 Hazleton Labs, Project No. 40703984, 3M Reference No. T-3609 000024 3M Fluorochemical EPA Submissions | C`eClhlrs,omMoistosmuablisAhbieCrhreatmiiocnalStSuadfyeotyfISnastmiptultee,DS-t1udiyn CNuol.tu2rLe1d62M,am3mMalian Reference No. T-6322.3 (FX-13 (`CM=ut1a~g8e)nsiucliftoynTyelsatmiinngoolfet2-h[yNl-aectrhyylla-tNe-ipnerBfalcutoerrioaallkRyelverse Mutation Assays, In Vitro BML, Study No. Microbiological M2u8t6a2g,en3iMciRteyfAesrseanycseoNfo.3MT-6C3o2m2p.a5ny('FsX-13 Compound T-3609, SRI Int, Project No. LSC-3145 Twenty-Eight-Day Repeated Dose Oral Toxicity Studyof Sample Din | NRaot.s,T-B6i3o2me2di(cFaXl-1R3escarch Labs, Study No. BMRI43C, 3M Reference || NEFOSEMA [Ae `Acutew Oral Tt oxicitye ScreenT with To -3494x in Albid no Ratsc , Safeti y Evaluy ation Lab, Riker Labs, 1048, FX-14) Project No. 0884AR0013, 3M Reference No. T-3494 (L- | PEvrailmuaartyioSnkiLnab[,riRtiatkieornLTaebsst,wPirtohjeTc-t3N4o9.40i8n8A4lEbBi0n0o1R2a,bb3itMs,RSeaffeerteynce No. T-3494 (L-1048. FX-14) "EAvcaultueatOicounlaLrabI,miRtiakteiornLTaebsst,wPirtohjeTc-t3N4o9.4Oi8n8A4lEbBi0no01Ra1,bb3itMs,ReSaffeerteynce No. | T-3494(L-1048, FX-14 I `Guinea Pig Maximization, Hazleton Lab, Project No. 40703983, SM | Reference No. T-3610 (NB No. 63601-32, FX-14) Tn Vitro Microbiological Compound T-3610, SRI Mutagenicity Assays of 3M Int, Project No. LSC-3145, Company's 3M Reference No. T- 3610(NB No.63601-32,FX-14) Genotoieiy EMviaclruoastioomneoTfetshte(MwuitthagienndiecpeAncdteinvtitryeopefatT)-,5N8O69TOinXt,hePAromjeecst SNao.lm1o1n5e9l6l5,a 3EvMalRueafteironeoncfethNeo.AbTi-l5i8t6yo9.f1T-(5F8M6Z9-3t5o5I9n,duLcoet 2408, wide-range Chromosome Aberrations in CPruoljteucrtedNoH.um11a5n94L3y,m3phMocRyefteerse(nwciethNoi.ndTe-p5e8n6d9e.n2t (rFepMeZa-t)3,55N9O,TLOoXt,2408, wide-range) ECevlalluGaetnioenoMufttahteioMnutTaesgtenwiicthAcLtSi1vi7t8yYofMTo-u5s8e69LyinmpanhoInmaVitCerlolMsa(mwimtahlian independent repeat), 5869.3 (FMZ-3559, LNoOtT2O40X8,. wPirdoej-ercatnNgeo. 115954, 3M Reference No. T- Page 20 000025 3M Fluorochemical EPA Submissions eoewseTo--te--ry `Acute Oral Toxicity Studyof T-6684 in Rats (OECD Guidelines), Corning Hazelton, Project No. CHW 61101149, 3M Reference No. T-6684 Primary Dermal Irritation / Corrosion Studyof T-6684 in Rabbits (OECD Guidelines), Coming Hazleton, Project No. CHW 61101150, 3M Reference No. T6684 Primary Eye Irritation / Corrosion Studyof T-6684 in Rabbits (OECD Reference No. T6684 Guidelines), Coming Hazelton, Project No. CHW 61101151, 3M Final Report, Acute Oral Toxicity Study of T-5898 in Rats, Hazelton, Study No. 40200468 Final Report, Primary Eye Irritation/ Corrosion Studyof T-3898 in 1 Rabbits, Hazelton, Study No. 40200469 Final Report, Primary Dermal Irritation / Corrosion Study of T-5898 in Rabbits, Hazelton, Study No. 40200470 `Acute Oral Toxicity --Rats, Biosearch, 3M Reference No. T-1388 perfluorooctanesulfonic acid) Qualitative Investigationofthe In Vitro Metabolismof 1-6292, T-6293, T-6294 LC/MS and and TL-C6/2M9S5/bMyS,RaAtdavnadnHceudmaBinoaHneaplayttoiccyalteSserUvsiicnegs lonSpray [Preliminary] Analytical Report, Report 96ADEMOI1.3M_ Teratology "DeMveemloopfmroemntEs.G. Lamprecht re Fetal Rat Lens Artifact -- Summary of mae Ion Spray LC'MC Determination ofPerfluoro Analytical Standards Provided by 3M Medical Department, Advanced Bioanalytical Services, No. 9SMYHWO1.3M Protocol, Feces Method Development Metabolism Study for Perfluorooctanesulfonate Derivatives, 3M Strategic `Toxicology Lab, Study Nos. T6316.17; T-6295.21; T-7132.3; ST-41 Protocol, Cell Proliferation Study with N-Ethyl Perfluorooctanesulfonamido Ethanol (N-EtFOSE; 3M T-6316.11), Perfluorooctane Sulfonic Acid PotassiumSalt (PFOS; 3M T-6295.16), and N-Ethyl Perfluorooctanesulfonamide (PFOSA 3M T-7091.1) in Rats, Pathology Associates Intl, Study No. 1132-100 [ 000026 CD No. 2 2000 3M Fluorochemical EPA Submissions ofthe Partition Coefficient (N-Octanol / Water) ofT-3874 by High Performance Liquid Chromatography (HPLC) i Environmental Fateand spo. BOD/COD TestingResults FC-120 `pSrtaotmieclAacsute Toxicityof FC-120 to the Fathead Minnow, Pimephales `OECD Activated Sludge Respiration Inhibition Test #209 -- Toxicity of FC-120 [Physical ChemicalPropertes-------------------- CShtruodmyoatfoSgtraabpihlyitywoiftMh eAtFoOmSiEcAEmiinsAiqouneoDuetseBcutfifoenrs Using Gas Environmental Fate and tsp "EnvironmFeatnetaardl Trane Activated Sludge Respiration Inhib--iFCt-1i09o-Xn_ mat i t on ee | bi Riigort --Fate of FluorochemicalsintheEnvironmental (sic) rae 22 000027 3M Fluorochemical EPA Submissions Read1y29Biodegadabiliy. "Modified OECD Serening Tes" for Fuorad Ecotoxic`iAtcyutEelteomxiecnittsy of FXC13 t fathead minnow EnviBrioonacmcFeuanmtuetalanaldtSitoudnyTranso; fSampleD-1with Carp (Cyprinis carpio [POA -- RaFtin,alBiRoedpyonrta,miAcns,AcuSttuedyInhNaol.a7ti8o.n7T1o8x4icity Study of1-2305 CoC Tn he I tFeirnmalsoRfeportor,ganAic ancdOriuanolrTgtaonxiicceifty (lLDu)CeonSttruradlyReiinseRnaatrsc,ehLntal,bRs&D Corp, FSitnuadylReNpoo.rt1, A37c-O3rMua0RleTf9toexri1ecein,tcyeSNtou.dyFloufoTr-a6d6F6C9-1i4nR3a,tLso,tC3o4m0ing HFaiznealltoRne,porSttu,dyPNro.iCSHkmiWnaI6rr1rit0atyi0on1S73tMu6Rd0-eyf.R.abFbCi-t1s,43Bioscarch, 3M ReFPfireoncareldeRurneecp),oerNto,BP.iorsTie-ma1ra3cr9h5y;,Ey3FeMCL-Rr1i4tae3tiofn SetNuod.ryT---Re1a3b9bn5i,tFscC(-W1ea4sh3out BibsearRcihg,gs,3M PrRimearyfEeyerNLorei.tTan-t1ic3on9e5S,tuFdCy---14R3abbits(NotWashed), BinakRgort,Primary Sin Irritation Test with T-3371 In Albino Rabbis, 1585; FC:26 (perfluorooctanoieacid FRinealfReeporrNto,e.ATcn-u1tc5e8eD5e,rFmCa-l2T6oxi(cpiertfyluSotruodoyctoafnoTi-ea6c3i4d2) in Rabbis, Corning. HFa1a14s2l6t,ons,oSdtiuudmypNeor.flHuworioSo0c8t0a0n3oa7t4e,so3lMutRieofn. No. FC-1090, L13364, Lot I, Pages 000028 3M Fluorochemical EPA Submissions `ClAonnAalsCeslofaLCienylelfTorrthae Tnesst CfheomairncdamClyaTt-ott2o9ix4i2ociCtnoyCi,nEtahveiCroInme1n0tTal7 PLa1t3h8o6l7o5gy Lab, Stone Research Lab, 3M Ref. No. FC-143 Lot 340, FSianlamloRneelploar/,MMiuctraogseonmiecPlEavtaeluTaestti,onLiotftoTn-2B0i1on5eCtiosC, fSntutdeyANom.es20838, 3M I RFeifn.alNRoe.poFrCt-,1M4u3tagenicity Test on T-6364 n an In Vivo Mouse NMoi.crFoCn-u1c0l1e5u,sLA-s1s3a1y6,7C,osmtiranigghHta-zcehlatinonA,PSFtOudy No. 17750-0455, 3M Ref. ``FAAibsnesaralryRawetipiootnrhstM,iunMlutCtihpailgneeensHieacrHivateymstsTste,esrCtooOmnviaTnr-yg65(H6aC4zHeOMlet)oanCse,ulrlSsit:nugwdiyCthNhroa.omC1oo7ns7fo5im0ra-m0la-tory 4Fi3n7aCl0R,ep3orMt,ReMfu.taNgoe.niFcCi-t1y01Te5s,tLwIi3t1h67T,-6s5t6ra4iignhtt-hcehaSianlAmoPnFelOla aEsCcohnefriircmhiaatoCroyliA/ssMaaym,mCaolrinianng~HaMzieclrtoosn,omSetuRdeyveNros.e 1M7u7t5a0t-i0o-n40A9sRs,ay3wMith RFienfa.lNRoe.poFrCt-,1M0u1t5a,geLnIi3c1i6t7y,TsetsrtaiognhtT--c6ha3i4n2AMPeFasOuring Chromosome AAbsesraryatwiiotnhs MiunlHtiupmleanHaWrvheosltse,BCloomodinLgymHpahzeolctyotne,sSwtiutdhy aNoC.on1f7i0m7a3t-0o-ry 4p4er9iCl0u,or3ooMctaRneof.atNeo. FC-1090, L13364, F11426, Lot1, sodium FAibnearlraRteipoonrst,inMCuhtaigneensiecHiatymsTteesrt OonvaTr-y63(4C2HOMe)aCseulrlsi:ngwiCthhraomCoonsfoimramlatory 4As3s7a0y,wi3thMMRuelft.ipNloe. HFaCrv-e1s0t9s0,,CLo1r3n3i6n4g,HFaz1e1l4t2o6n,,LSottud1y, sNoo.di1u7m073.0- FpienrailluRoerpooorctt,anMousttaegenicity Teston T-6342 in an In Vivo Mouse MNioc.rFoCm-u1c0le9u0s,ALs1s3a3y6,4,CoFr1n1i42n6g;HaLzoetlt1o, ns,oSdtiuudmy Npoe.rfl1u7o0r7oo3c-t0a4n5o5at,e3M Ref. `FEisnocmahilenRrgieephoHiraatzCe,olMltuoitna/,gMeSantmuidcmyiatlNyioT.aens1t70Mw3ii0tc7hr31o--0s-6o43m04e92,Rie3nvtMehreRseeSfa.MluNmtooan.teiFloCln-a1A--0s9s0a,y, ._EI33@MERI426, Lotl, sodium Perfluorooctanoate I += FRBAR@WixPgIitgo,ggmicityVoSltuumdeyso1f4F,lTuowroocYheemaircOarlalF(CD-i14e3)iTnoRxaitcsi,tRyiker Labs, SFHidnaRbNRep:or0t2,8Ni1nCeRt0y0D1a2y Subacute Rat Toxicity Study on Fluorad RFehfuearreonccheemNioc.alT-F3C-114413, ntl R&D Corp, Study No. 137-089, 3M 3MIntemmalCorrespondenceroFC-143analysisofserumsamples from 0, 1978 Page2s 000029 3M Fluorochemical EPA Submissions o3fM9I0n-tdearynsaulbCaocrurteessptounddye,nfcreotmeJFoCn-B1e4li3salneatloyJsiEsoLfongiv,edrsaatmepdMleasrcfhro3m1,rats 1978 FInidnuasltRrieaplorBti,o-2T8e-sDtaLyabOsr,alStTuoxdiycNioty. S8t5u3d2y-1w0i6t5h5F,C3-1M43ReifnerAelnbcienoNoM.ice, T-1742CoC, Lot 269 FInidnuasltrRieaplorBti,o-2Tes8t La-Obrs,aDlSTtouaxdiycyiNtoy. S8t5u3d2y-1w0i6t5h4F,C3-1M43ReifnerAelnbcienoNoR.ats, T-1742CoC, Lot 269 FwiintahlTR-e2po6r1t8,CRoeCpeiantAAlpbpilniocRaatbiboint2s8, SDaafyetPyeErvcaultuaantcioounsLAabbs,orRpitkieronLSabtsu,dy l SFtiundayl RNeop.or0t9,7N9i0nAeBtOy4D8aSy, S3ubMacRuetf.e NRoh.esFuCs-M1o4n3key Toxicity Study, Intl R`&AnDalyCtoircapl,daSttau,dyFCN-o1.4313An7a-l0y9s0is ofIRDC 137-090 Samples [monkey sFienraulmRaepnodrtli,veVrols.am1pl,es),13-3WMeeCkenDtireatlarRyesTeoaxriccihtLyaSbtsudy with T3180, AHamzemlotonni, uSmtudPyerfNlou.oroHoWctIan6o3a2t9e-(10C0AS No. 3825-26-1) in Male Rats, RFaitnsa,l CReopmoirnt,g5HaDzaeilltoynD,osSteudOyralNoTo.xCicHitWy S6t3u2d9y-1w9it7h 1-669 (FC-143) (A26P-FWOe)eiknCaCpysnuolmeoTlogxuisciMtoynSkteuydsy,wiCtohvaAnmcmeoLnabisu,mNoP.er6f3l2u9or-o2o3c1t,an3cMateRef. No. T-6889.3.InProgress. Protocol provided. SFtinuadlyoRefpoTr-t6,0A6n7aliyntRiacbablitSst,ud3y,MSRienfg.lNe-oD.oLs1e3I4n9t2r,avSetnuodusy PNoh.arAmaMcDokTi-netic 120694.1; report Pharmacokinetic Sintculduydoefs TF-in6a0l6R7epionrRta,bSbiitnsg,leH-aDzoelsteoInn,tSratvuednyouNos. HWI 6329-151 TF-in6a0l6R7e,pTo-r6t0,6A8n,alayntdicTa-l6S0t6u9dyi,n SRaibnbgiltes-,D3osMe AEbnsvoirropntmieonntTaolxiTceicthynSotluodgyyo&f `SSeirnvgliecreDsi,tSgetuAdbysNorop.tAiMoDnTT-o0xi1c1i0t9y5S.t1u;dyroefpoTr-t6i0n6c7l,udTe-s6F0i6n8a,laRnedpoTr-t,6069 in RiabbBiieelton, Study No. HWI 6329-152 Dose; Rikes Labs ChefmaibcalEspoDr,ivSiysnitohneasinsdaRnidkCerhLaabrs acterofiFzC-a14t3i-1o9Cn, Commercial TFoitnaallCRaerpborotn,-E1x4tiennMtaalned aRnodutFeoemfaElxecRraettsioAnftaenrdaTSiisnsguleeDIiVstrDibuotoiosfn FoeCf- 143-14C, Riker Labs Page 2s 000030 3M Fluorochemical EPA Submissions Final Report, ExtentandRooufExtcreteion ofTotal Carbon-14 in PPreergfnluaonrtoRocattasnoAate,faRiSt kienrge lLeabOr sral Dose of Ammonium 14C- RaFitnsalwiRetphoCrhto,lEenshtaynracmeidnEeliTmrieantamteinotn,oRfiFkCe-r9L5a-b1s4C and FC-143-14C in FininRaalbbRietpso,rtC,orSniinnggleH-aDzoesletoIn,ntrSatvuedynouNso.PhCarHmaWco6k3i2n9e-ti1c86Study of T6564 I FininRaalbbRietpso,rt,C5o-mmDianiglHyaDzoelsteonD,ermSatudly AbNsoo.rCptHioWn6T3o2xi9c-i1t8y5Study ofT-6364 `SOtruadyl RaNnog.e0fi6n8d0eRrRS0t0u1dy8of T-2998CoC in Pregnant Rats, Kiker Labs, FStiundayl RNeop.or0t6,8O1rTaRlOTLe1r0a,towliotghyAStmuedynodfmTe-2nt9to98FiCnaolCRienpRoarttsa,nRdikPerrotLoacbosl, `Oral Study Rangefinder Studyof No. 0681RBO331 T-3141 CoC in Pregnant Rabbits, Riker Labs, Final Labs, RSetupdoyrt,NoO.ra0l6T8e1rTatBo0l3o9g8y Studyof T3141 CoC in Rabbits, Riker I LD. Winter 10 DR. Ricker Letterrefurthertesting fromE. MarshallJohnsontoDr. Franklin D. Griffith 3AdMamMse,moerncelosFinCg-9a5naannadly1s4i3soTefrtahteoeloygeyl,efnrsdomefMeacrtv Case to Georjean | FFA.lUubelo, ert ao. H--ceAalhPtrheeSltiammtiunsiaofryPcRleaapnotrltWo,s4r1keArms.ExIpndo.seHdygt.o AssocJ..584- 589 (August 1980), with Summary. LeSonatrodfuMEm.pdSlocyhyeuemsanat&thJeaCchkeSm.oMlaintdeePll,anAtn(FEepbirdueamriyol1o9g8i0)c,Mwoirtthality ummary of study. ChJaecmkoSl.iMtePalannt&" L(deJaonunaearyrdl1M9,89S).chwuimatnh, "SMummoarry taliotfy Sstudyt. uatdtyhe 380 FPerrfDgszagGiilnlnioliacnkdA&ciJdaPcrkoSd.ucMtainodnelP,laMnto,ra3l5iJtyOAMm95o0n-g95E4mp(lSoeypeteesmboefra Div Ocapatianal GCiollhiolarndt,(OFctolberu199o2) (arunndpouHbulimcsahneadHePahrl.tDh.:btShteusodisi,cnsUniiavsaernsity of Mikdmn), with Summary. `GHeoarrmyo:nWeesOliniMne,cntwail.t,hAOcncEuppiadteimoinoalloEgxipcoalsuIrnevetsotiPgeartfilounoroofoRcetparnoodiuccAtciivde, 40 JOEM614-6(1l9y 1, 1998), with Summaryofstudy. Page 26 000031 3M Fluorochemical EPA Submissions Frank D.Gillilan&d Jack S. Mandel, Serum Perfluorooctanoic. Acid and HepaticEnzymes, Lipoproteins, and Cholesterol: A. Study of Occupationally ExposedMen, 29 AmeJor urni alofc Inda ustrn ial Medicine 560-568 (1996), with Summary ofstudy. GCheoalreycyWs.toOklisneinn, aentdalH,epAantiEcpiFduenmcitoiloongiincPIenrvfelsutoirgoaotcitoanonoficPlAacsimda Production Workers, 3M Final Report EPI-0003, (1997), with: `Summary of `study, Protocol, and Manuscript acceptedforpublication in 2000, Drug & Chemical Toxicology. Physicians Plant Summary Reports Re Medical Surveillance Program at ottage Grove (1978-1991) 3M Internal Correspondence re 1981 Chemical Division Health SEEvvMaallIuunsstieioronnnassl,fCforrroormmeDsDEpEo..ndRReoonaaccechhrtetoo1P9PF8E.1. RCRiihechehlimeeis Fal 3M Internal Correspondence re Inorganic Fluoride.Determinations, from D.E. Roach to P.F. Richle | 3M Internal Correspondencere Organic Fluorine Levels, from D.E. Roach to P.F. Richle 3M Internal Correspondence re Medical Examinations, from L. Zobel to D.W. Dworak - 3M Internal Correspondenrcee Chemolite Evaluations, Fall 1990, from R.Zotb oCle ail r Murphy, etal. LetterfromE.Marshall Johnsonto William C. McCormick, III, re Hazelton teratology studies Letter from E. Marshall Johnson to WilliaCm. McCormick, II re Riker teratology studieson PFOSandethyl FOSE LetterfromE. MarshallJohnsontoWilliamC. McCormick,IIIre Riker Teratology stuondPFiOSeansd ethyl FOSE FinalReport, Biological Phase, Metabolism. of N-Ethyl Perfluorooctane `FoSlullgfwainnogm#iddmoiEntihstarnaotli(onN-EotfFaOSSiEn;glTe6C3a1p6s)ulIen DCoysneo,moColvgaunsceM,oSntkuedyysNo. yr ---- Technical Report Summary -- AdsorptionofFC-95 and FC-143 on Soil, an acrid tique fromDr.S. Boyd, MichiganStateUniversit I (FC-1 re . 000032 3M Fluorochemical EPA Submissions `SuTnelcihgnhiical Report Summary -- FC-143. Photolysis Study Using Simulated TechnicalReport Summ--aAnarlysyis for Fluorochemicals in Bluegill Fish, ana cdritique by JW. Gillett of Comell Universit Ready biodegradation of FC-126 (BODICOD) `Technical Report Summary -- Assessment ofthe Bioaccumulative Properties of Ammonium Perfluorooctanate: Static (fish test) 969-h6our-accuuhtteesstotaattiicuctotxoixricciittyy ttoo fblauteghiellad msuinnfnisohw ~--FFCC--12463 Two Reports: "The Effectsof Continuous Aqueous Exposure to 78.03 on `Hatchability (Pimephales opfrEogmgelsasa)n"daGnrdo"wStuhmamnadrsyurovfivHailsotfoFpartyhoolfogFiactahlead Minnow Examinationsof Fathead Minnow (Pimephales promelas) Exposed to 78.03 for 30 Days" Technical Report Summary ~ Aquatic Toxicity Testing: FC-143 ( Lot-37) LR. 56258 `Technical Report Summar--y Multi-Phase Exposure/Recovery Algal `Test method (FC-143) diet) Chronic Tox ofiFluc oroi chet micy als to Daphnia `magna (Water Flea) -- FC-143, andstatistical analysis ofdata 96- acuth esto aticu toxir city tofathead min--n FX-o10w 01 [SoaeueToxicity to theFalheadMinnow,Pimephalespromelas | Paes 000033 3M Fluorochemical EPA Submissions Activated Sludge Respiration InhibTi est t--Fi C-1o 015n -X I GAcruotwethToaxnicdiRteyprofodFuCc-t1i0o1n5TtooxitchietyFaTtehsetawdiMtihnFnCo-w1,015 and thePimephaFles rpersohmwealtaesr AcuteToxicity of FC-1to0t1he5 Daphnid, DaphniaMags PFOS d dimethylammoniumsalt Determinationof the 28-day Carbonaceous Biochemical Oxygen Demand (CBOD) for P3025 AcPuitmecpThaoixs pirocofmiPe3lt0s2y5 Developmental Material to Fathead Minnow Acute Toxicity ofP3025DevelopmMaetnertiaaltlo Daphniamagr GrowthInhiofbP3i02t 5Gri eenoAlnga (Selenastrum capricornutum) Growth Inhibitionof P3025toGreenAlga(Selenastrumcapricornutum) Inhibitory Effectsof P3on0Mi2 cro5 tox Inhibitory Effectsof P3025onActivated Sludge Respiration Vebirters PesfBuooeronocdineBesporuarlefoTn] rfuaoriide an Perfluorooctanesulfonamide Perfluorooctanesulfonylamido (ethyl) acetate N-ethyl perfluorooctanesulfonamide N-methyl perfluorooctanesulfonamide N-methylperfluorooctanesulfonamidoethianol teenie bere = Er ey [ToxieoWgreatStidies andOther RelevantInj on on PFOSMixtures `FinalReport,InVitroMicrobiologicalMutagenicityAssaysofThree 3M. `Company Compounds, 3MReference Nos. T-2136 [FC-206], T-2138, T- 2140, SRIIntl, Project No.LSC 4442-16 res 000034 3M Fluorochemical EPA Submissions FionmaplanRye'psorCto, mInpVoiutrnodMiTc-r3o6b51i,olSogRiIcIanlt]M,utPagernico Nitoyj .ALse SsCa-c y3s1ot 4f53M oTFT EE -- Feotosicin Elements AquaticToxicityTesting:FC-185F(cc817-19) L 1-2303 LR 7544 (Fathead Minnow) Foam c`MoiSlmuipmtomauranyrdyTsfeofcshrwnooomlrokmgpuyleiaprnlfdcoPorrommcpfueoradresmteshnetGoenrmfiarne eGxotvinegrunimsehinntgAfgoeanmcy for eEE------ a Acute static toxicity of FC-201 to fathead minnow Fevtarcin Hemens Acute static renoe fFCw-2a 01AlF to fathead minnow [FC-201 AF Light Water BrandAFFF Acute Toxicity Test withthe Marine Copepod Acartia tonsa -- FC-201AF `ALciguhtteTWoaxtiecriBtyraSneddiAmFeFntFTest with the Marine Amphipod Corophium volut--aFCt-o20r1AFLight Water BrandAFFF Acutestatictoxicity of FC-201AtFo Daphnia magn: 7 rete ------ ee FF SF FF e H Vi FFrao mrea a FurtherInvesotn tihegAcautteTioxiocintyof FC-201tFo Fathead re 000035 3M Fluorochemical EPA Submissions Acutetoxicity tofish (leuciscus idus) Ecotoxicity`AcutEelteoxmiceitnytsofFCI0TF-X io Mircaior Environmental Fate and sport Repeat OECDBiodegradation Teston FC- an6 dF0 C-20 03 Acute toxicity of Light Watt o ble uegr ill (Lepomis macrochirus) fasciatus Acute Toxicity of 3M Samples (A and B) to the Water Flea. (Daphnia magna) andScud (Gammarusfasciatus) --robustsummary of Gammarus `Acute Toxicity of 3M Samples (Aand B) to the Water Flea. (Daphnia mfaasgcniaat)usand Scud (Gammarus fasciatus) - robust. summary for Gammarus Algicidal Activity ofTwo Samples Labeled "A" and "B" Acute static toxicity ofFC-203torainbow trout (Palaemonetes pugio) Acute Toxicityof7902 to the Common Mummichog (Fundulus _heteroclitus) `Acute Toxicityof3M Company's Sample 7902 to embryos -- larvac of Acutetoxoi fSac mpi le#t 57y 29toembry--olarvae ofeasternoysters = | |ZScwiowWsgiiRosToorficFtCy-o20f3FwCi-t2h0o3uttoTtohlyetiDraapzholneid(,VDWi1p6h0n3i9a0m)taoMgicrnotaox ]| ~. Keo TORERy Sediment Testwith theMarine Amphipod Corophium [----GrowihInhibTeisttwiithotnheMarin AlgaSAkcealrettoanteomnsscaostaram extinguishing agents inthewastewater rages 000036 3M Fluorochemical EPA Submissions --Robust Summary for FC-203 `Environmental Effects of LIGHT WATER Brand AFFF and Components --Robust Summary forVW160390 (FC-203withouttolyltriazole) a ES ---- Ey --| 2 EE -- Feoasiciy Elements Acute Toxiciotfay Surfactant Solution (81-1/8) to theMummichog Fundulus heterocliitnuas Flow-through Sy . Ready biodegradability (BOD/COD) ES & TOCof FC-203CE. -- Toxicity of FC-2t0 oM3 icrCotE ox Bvitonmenta] Effectsof LIGHT WATERBrandAFFF and components Es errmEo | roe 000037 3M Fluorochemical EPA Submissions StatieAcuteToxicityofFC-203CFtotheFathead Minnow,Pimephales "ASctauttiectAocxiuclietTyoxoifcFityCo-f F2tC0o-M3i2crC0otto3oFtxC.heF Daphuid, Daphnia maga cStaaptriiccAocruntuetuTmoxicityofFC-203CF to the Alga, Seleaastram A`cAuctuteetotoxxiicciittyyooffFFCC--20230CFtt3XooCniatcFrtiifv-yaitXnegd sbaucdtgeeriami(xIeSdO/lDiIquSoMrethod 9509) A`cAuctuetTeoxitocxiciity tyofofFFC-C2-03to2tCFoaFt0mXhieiaf3ydiMniCgnbnaFcotweria((PNiimferpohsaeleedsMeptrohmeoldas)) RI335 BOD Report for3M Compan Toxicity Toxicity ooff FFCC--2tt20ooaMc03itrievF3oattoCexFd.slCodgemixedIigu ``GArcuotwetThoInnhiicbiittyioonfRofIRI33t33o55forDaGphrnieaenAlgmagsa (Selenastram capricormutu) A`cAuctuteeTsotxaitciittoyxiociftyRIo3f35FtCo-F2a0th3eFtaCodMfianthneoawd mi(nPnimoewphales promelas Ecotouxicity Elements Acutetoxicityof FC-toR2ain0bo3w Tr8out Ready Ready biodegradability biodegradability ofFC-206 of FC-206 (BOD/COD) (BOD/COD) EfBifoedecgrtadoatfion degroadfati"onLoInGfHToWAaTmEoRfiF"CPn-ro2dg0u6ctsin OECDTest -- 6/80 Summary ofmistobialibibition (dehydrogenase activity) esonFtC-2s06 AREREERSy ofSample toMumumichog (Fundulusheteroclit), `GRiOlMaEshSa:iEar(yPaflioemronemtuesmmicvhuolggaris)andFiddlerCrab(Ucapugilator) - coNliy GAASEFin (ofPSampalo CltvoulMs goamrime si)acnhm doFgi(dFo dulnedrun Clruasbbe (eUtecratopoulgie isl)at,osr)-- G`rAcaustseSThorxiicmipt(yPoaflaSeammopnleeteCsvtuolMguarmimsi)canhdoFgid(dFluenrdCulruasb(heUtceraopculgiiielsa)t,or) -- `RAocbutuestToxsiucmmiatryyoffoSrafmipdldeleCrtcroabA.tlantic Oyster (Crassostrea virginies Pages 000038 3M Fluorochemical EPA Submissions Acute Toxicit `ofSample Cto WaterFlea (Daphniamagna)andScud A(cGuatmemTaorxuisciftayscoifatSuas)mp--leRoCbutsotWastuemmrarFylefao(rDSapchundia magna) and Scud Acute static toxicity ofFC-206 amended to soil to fatheadminnow Investigations oftoxic effects and `biological degradability of foam extinguishing sgents intewastewater M`iSluimtmaaryryTfeocrhwnoolrokgpyerafndorPmreodcfuorretmheenGteornmfairne eGxotviengrunimsehnintgAfgoeanmcyfor FCAcompounds frommultiplecompanies a ST -- -- FsuCn-fi2s0h)6A cc 785-22: ResultsofAquatic 96-hr. LC50 Tests(.bluegill Acute toxicity of FC-206tAo Daphnia magn: Feamc [Rea = dybiodegradability (BODICcODoYmofeFrCZ0BE Acutetoxicity of FC-t2oa0 cti6 vatC ed shudge mixedliquo AcuteToxicityof a Surfactant Solution to the Mummichog (Fundulus heteroclitus) in a Flow-through System. (FC-206 ----foiobgradability (BODS/ECOD)ofFCI06CE --| [ AcuismiotocicityofFC206CEtoDaphiia maga ge 34 000033 3M Fluorochemical EPA Submissions ASScttuaatttiiscctAAoccxiuucttieetyTToooxificcFiittyyCooff-FFCC-2+2-0a026nCi0Ef6t6otoaoCtCmtheEhereEtADolagpaahcn,tiidSv,ealieeDndgsshsdrrgutmesnmmaigneed Tua ~EnRvoibruosntmentsaumlmarEyfffecotrsFoCf-L2I0G6HCTEWATER Brand AFFF and componeas FCa06CE Ready biodegradability ofFC-206CF (BODICOD SptraotmieclAacsute Toxicity ofFC-206CF to the Fathead Minow, Pimephales S`tAactuitceAtcoxuictiety ToorfFiCi-2o0f6FCCEt-o2M0i6cCrfaFolotxhe Daghiid, Dapha mage Static Acute Torisity of FC-206CF to the Alga, Selenasrar F600Acute toxicity ofFC-2060F-X to activated tgs mixed Tigao EnvirTSoeuncmhmmeaRernpyFtooraftelrSeauanmdmdyaTbrriiaoendssepgradabily Sudies on FC600, Lab Worksheet. A`Accuttessttaattiic ttooxxiicictiytyooffFFC-C60-0tto6o bl0bueeg0aidllmsuinzfmisohw `eAcufte fsaftrilocmtaunoFeCx-no6if0tc0FC---i6e0txp0otysoedDaSpChAnSiaremaaesgonr a~ irofsSadies oF eh`foAfculurutseeonsfttftarrtoiecmattaomxneincFtiCty-o6f00FC~-e6x0p0ostoedDSapChAnSiaremaacgtnora(~csaetceodnrdeaocfto3riaafdeires4.oF ae`ffAftcleuurtee&ns-tthfaotowircmsotoafxnitcrFietCay-tom6ef0nFt0)C---e6x0p0otsoeDdaSpChAnSiarmeaacgtaora(~b(lrandk coofnt3roslturdeiaecstoorf |Acutsmoxi ieity ooffFCC0-to6aoci0Avaui0eedr,BsadegelgmiixaendtoTsiuorcr de [a P | ne gs leostudy ooffaccuutseotoxnicityy ooffFFC5-06000 (l(US) fgo F)athoeafdameisnanow [RingRmaiingmeon-fwingdingstusmadtyyoofaaciutee tooixciicyityooffFFCC.-660000 ((B0eS)lg5iuma)hteoafdatihead.e DynamicAcute ToxicofiStMyT to Fathead Misnows (Pimephales quatic Toxicity Tesing FC600 (Belgium AFFF) LRI595 rages 000040 3M Fluorochemical EPA Submissions `Acutestafic toxicity of FC-t6ofa0thea2dmi-nnXow `FGCr-o6w0t2h) Inhibition Test with the Marine Alga Skeletonems costarum FC03EvoFlutator (FC-602) Acute Toxicityof FC-G03EF, Light Water TM ATC 3% AR-AFFF io `Growth InhibitionofFC-603EF, Light Water TM ATC 3%, AR-AFFF fo AcuteToxicityof FC-60Li3ghEtWaFte,r TM ATC 3% AR-AFFF to Fathead Minntiw (Pimephales prom [I XGSFTEIELy etAdCin SediTemstewitnhtthe Marine Amphipod Corophium Page 36 000041 3M Fluorochemical EPA Submissions E r-- E -------- Toxicity ofFC-t6o M0icr3otoFx. Acutetoxicit of FC- toa6 ctiv0 ate3 dsluF dgemixed liquor Ready biodegradability (BOD/COD) of FC-780 Acute toxicityto Mummichog Fundulusheteroclitus) FC-780B Ready biodegradability ofFC-780B (BOD/COD) Ready biodegradability of FC-780B(AFEFC) (OECD ClosedBottle Test 780B (lot 788-20): ResultsofAquati9c6 Fir. LC3g Tests Acute Toxicity of 7901tothe Common `Mummichog (Fundulus hDePtiermoyecplihtau6nls)s HporaoumreAlmcaswsiTorcey oF3M Sample 13 i Fated Mims Environmental Fateand Ready biodegradability po (BOD/COD)of FC-783 mactochius -- Acute Toxicity of3M|`Sample No. 6toBluegill Sunfish(Lepomis Acutetoxicity of FC- toa7 ctiv8 ate3 dsh dge mixedliquor Ready biodegradability ofFC-787 (BOD/COD) SAtcautitceActouxitcietyTooxifcF ityC of- tFo7 MC ic8 rtoo- tt7 oxh_e7Dap8 haid7,= Daphnia maga `FlowThroughAcuteToxicity ofFC-787 tothe FatheadMinnow, --r rri ---- -- ---- ---- -- -- Thine 30toa0ctiv3ated siadgs med ams e mr eFa --------------------| Gio hibition of R1331for Green alga (Selenastrum caipr comutum) Acutestatic toxicityofFC- to f3 athe0 adm0 inn3 ow Acute Toxicit ofR131 to FatheadMinnow(Pimeph es promelas) Biodegradationof "Light Water"Productsin OECD Test--6/80 [ 000042 3M Fluorochemical EPA Submissions Mi`lSiutmamrayryTfeocrhwnoolrokgpyearnfdorPmreodcfuorretmhenetGeornmfairne eGxotivnegrumisehnitngAfgoeanmcy for FC-3041 SE -- Ready biodegradability (BOD/COD)of FC-3041 BInavseestFiCg-a3ti0o4n1f.orAtnhaeerEocob-itcoxDiecgorlaodgaitciaoln.EvPaalrutatfionofthe Fluoro-surfactant IBnavsesetFiCg-at3i0o4nf1o.rAtnhaeeErcoob-itcoxDiecgorlaodgaitciaoln EvPaalrutagtion oftheFluoro-surfactant [00 [= MB titty(BODICOD)ofFX310 | RS toi ofFX-3103tofatheadminnow | [ 000043 3M Fluorochemical EPA Submissions " BX Ecatoxicity Elements Acutestatictoxicit Acute statictoxici ofFX-3104to fatheadminnow of FX-3104toSelenastrum Acutestatictoxicityof FX-31t0o4 Daphaia pricomutum m gn Toxicit ofFX-3104toMicrotox. em] Ready biodegradability Ecotoxicity Elements (BOD/COD) ofFX-3106 Acute staticrenewal toxicil of FX-3106tofatheadminnow mpe-- d rermt-- --Go-- nvEoDy argo Ecotoxicity Elements MiscellAacnuetoeusstSattuicdtioexiscit OfL-4647tofat-headminnow res 000044