Document 1QLRM2mK6MwwZOv0eEdErRb2j

' x. x# X:X *'.' <.. f*v5*'r'^v sti.: . s*rwv'V"" 61 nil trad miniIfeaK. from con* t*. .Iri.l Hvuicnc OlK''l M.iri;!,, I 9U The Uc of Plwercnprot ^bAt*) in yl>v Treatment jf tlinhniimi 0nly V>)m. I'm -mniu^. hTTT MacKarUnd, Arch. Luvit-vimiiuriUl ilvallh *4nF^A'/C (iJiTc'/^V.-d), Dosage-inurtality data have iiovn ohtainud from 200 g, Wistur rata subjected to a single, 15-minute exposure to arc-produced cadmium oxide fume, Anuly#i '( the results by the problt technique yielded ait ustinutc for thu i.(Ct)50 uf 666 rug, mli. /cu. m, , with con fidence limit# of 63) and 764 at the 95*i level of probability. For the LfCUVS, an estimate of (Odd mg. min./cu.m, was obtained, with Jimlle of 196 and 2,266. fhu ufficacy of dimorcaprol in reducing mortality and in prolonging survival time of rate exposed to 3. 1 to 4.5 time* the L(Ct)95 of cadmium oxide fume has been examined in 3 factorially-deaigned experiments. Nearly complete protection againat the lethal effect was obtatnrd with a Jyily dose of approxi mately 100 mg. of dimorcaprol administered subcutaneously in divided doses. Two factor*, amount of dimercapro) par injection and frequency uf injection# pur day. were varied in these experiments; however, the protection afforded was found to depend on thu total daily dose of dimorcaprol. There result* have been diacusaed along with other relevant pubiiahed data, and tl i# concluded that a reconsideration of the clinical uae of dimorcaprol in acute cadmium oxide fame intoxication ia warranted. -- Author1! luminary *Vi Effect on Environmental Temperature and Humidity on Lmd Hxhonlng in Animiii, A. M. Daetjor, S. N. U, Joardar and W, a. McQuary. Arch. Environmental Health 1, 403-477 (Dec. 1960). Mice exposed to an environmental temperature of 95*F when Injected with lead iMraperitoneally or intravenously began to die eooner, had a higher mortality and shorter vrMgc aurvival time than mice at 72*F. Thia effect of high temperature on acute lead j>*;awning war more marked when the exposure followed immediately after the injection of lead than when expoaure to heat alao preceded the lead poisoning. The results were similar eliHher a high or low humidity accompanied the high temperature. Prolonged exposure to H*#i preceding the injection uf lead did not reduce the harmful effect of heat exposure. Re moval from heat at nights Alleviated the effect to some extent. Exposure uf rats to high temperature similarly increased their mortality following the intravenous injection of lead. Mire exposed to an environmental lemperotur* of 60*1-'* had a higher mortality and longer average survival time than those exposed to 72* F temporaturo when injected intraperltoneally *uti led, but no significant differences were found when the luad was injected intravenously. Mice with chronic lead poisoning, produced by rupeatod injections of load, began to die sooner ei.iJ had a higher mortality when exposed to a high temperature following cessation of lead In- )c.'IUjii#. Severe dehydration produced by restricting water consumption increased the mor- t*`ify vi| n.lcc from acute lead poisoning at all temperatures. The effect was much more n..irkd whr.n the lead was injected intr&peritonoally than when injected intravenously. Weight Ami decrease in activity which oceur upon exposure of mico to heat, when produced at * 'r,,5#t tnnperoture by food restriction and isolation, did not increase their susceptibility to *',J* - - Cond. from authors' conclusions ,tf 1 -M in Paint Scrapings as an Aid In the Control of l.exd Paint Poisoning in -^UL^ljdrun. E. Kaplan and R. S. Shaull. Am. J, Public Health 5I_, 65-69 (Jan, 1961). ( order to prevent lead poisoning in children caused by ingesting paint from surfaces # !' *'1** peint containing lead, public health authorities are requiring warning labels on paint 4" t 111 bKce of 1 Vi, they are prohibiting the interior painting uf dwelling units with such fl -rt* ordering the removal of paint containing lead where it presents a hazard to t,,Ml4ren. a simple and inexpensive procedure Is described for rapidly screening paint ^'"gs at the l % level to determine compliance with thuee regulations. Authors' abst. [T`,'i"`~r-"li*rri H"`* in Mxnpaneie Poisoning. D. L. Ovedoff. and F. Kuinhold. Uolunnusburg) 6, 195-19? <M*y 7, i960). e```lujiye ^ 'li",orY and neurological finding# drtcribvd in 5 patients shu* that parkinsonism (i.lWy V*Ur r*^*tively short exposures, from 6 to 24 months, to manganese fumes in a 6ntieeburg where ferromanganese steel is produced. Apparently the oldest was 13. rUSiiv