Document 1Q3x0goZRqzwRxEoyEZM6VBVm

TO: Distribution $&' bd0: RF XF: >>>c------------------ Interoffice Communication FROM: DATE: SUBJ: T. G. Grumbles October 5, 1989 NIOSH RESPONSE TO OUR HHE REQUEST VB1A Attached is NIOSH's official response hazard evaluation at the LCVCM plant. not going to do an investigation. . >yt'v to our request for The bottom line is a health they are The letter is somewhat confusing but I believe a fair summary is that larger studies have failed to confirm an association, and studying a small population will not provide any definitive answers regarding causation. With this response and the ongoing neurological evaluations, I believe we have completed the current outstanding action items. At this time, we need to decide what our next step is. For example is it useful for Dr. Drumwright and I to do another series of employee meetings? Please let me know your thoughts on what we should do next. T. G, Grumbles dlj Distribution: N. Frost, W. L. McClain, T. H. Huffman, J. R. Drumwright, R. D. Gamblin R. A. Conrad-LCVCM Attachment VVV 000014203 DEPARTMENT OF HEALTH & HUMAN SERVICES Public Health Service Centers for Disease Control National institute for Occupational Safety & Health Robert A. Taft Laboratories 4676 Columbia Parkway Cincinnati OH 45226-1998 September 29, 1989 HETA 89-356 Mr. Thomas G. Grumbles, C.I.H. Environmental Quality Manager Vista Chemical Company P.0. Box 19029 Houston, Texas 77224 Dear Mr. Grumbles: I am writing in response to your letter of August 24, 1989, requesting a health hazard evaluation at your vinyl chloride monomer (VCM) production facility in Westlake, Louisiana. According to your letter and a subsequent telephone conversation September 5, your request is limited to an evaluation of the occurrence of brain tumors among plant employees. Information supplied by you and by Vista's corporate physician. Dr. o.R. Drumwright, indicated that one current employee has a brain tumor, a glioblastoma. Another reported brain tumor was actually a lung cancer that metastasized (spread) to the brain. In addition, 5 or 6 years ago a former employee had an ependymoma. (Glioblastomas and ependymomas are considered different types of brain tumors, although both arise from neuroglial cells.) Other tumors were reported in a spouse and a child of employees. Finally, there was a case in an employee who worked at the plant prior to the beginning of VCM production. Eighty to 90 employees are involved in the VCM production process. There is relatively little turnover, and there have been only about 140 employees in VCM production since it began about 20 years ago. In the United States, the age-adjusted incidence of brain tumors (all types) in men is about 6/100,000/year, and the incidence of glioblastoma, the most common type, is about 3/100,000/year. Thus, the occurrence of two primary brain tumors, or even one glioblastoma, in a population of 140 over a 20-year period would appear to be an excess. This, however, is a very crude analysis and would be affected by the age distribution of the workforce and the number of person-years at risk (rather than simply the number of workers). Glioblastomas comprise about half of all adult brain tumors, are more common in men than women, and have a peak incidence at about age 60. Ependymomas, a much less common type of brain tumor, occur about equally in men and women and also have a peak incidence at 50-60 years of age. Assuming that the VCM production workforce at Vista's Westlake plant is mostly men, and that the size of the workforce has been constant, composed of 90 vvv 00001^2^ Page 2 - Mr. Thomas G. Grumbles, C.I.H. people at any one time, there have been approximately 1800 person years at risk since VCM production began. The expected incidence of glioblastoma, assuming most of the workforce is now in the 40-60 age range, would be about 5 per 100,000 person-years, yielding about 0.1 expected cases. The expected incidence of ependymoma would be about 0.15 per 100,000 person-years, or 0.003 cases. These expected numbers of cases are only accurate to the extent that the assumptions about the workforce are correct. The actual number of expected cases, for example, is probably less; lower incidence rates would be used in a more rigorous calculation since, in previous years, the workforce was most likely younger than it is now. Also, if there were additional cases in former workers, the difference between the observed and expected numbers of cases would be even greater. Previous studies of workers at facilities that made or used VCM, including one done by NI0SH (Waxweiler RJ, et al. Neoplastic risk among workers exposed to vinyl chloride. Ann NY Acad Sci 1376;271:40-48) and one done for the Chemical Manufacturers Association (CMA) (Wong 0, et al. An update of an epidemiologic study of vinyl chloride workers 1942-1982, final report to Chemical Manufacturers Association. Oakland CA: Environmental Health Associates, 1986, unpublished), which updated earlier CMA-sponsored studies, have indicated an excess of brain cancer, particularly glioblastoma. The CMA study included Vista's Westlake workers and is reportedly being updated again. A recent update of the NI0SH study (Wu W, et al. Cohort and case-control analyses of workers exposed to vinyl chloride: an update. J Occup Med 1989;31:518-523), however, which enlarged the earlier NI0SH study cohort and included more recent mortality information and a more detailed exposure classification, aid not find an excess risk of brain cancer attributable to VCM exposure. It is unclear why the previously identified increased incidence of brain cancer was not corroborateo by the recent NI0SH study, which had greater statistical power. Perhaps the earlier studies' findings were confounded by other exposures. The anticipated report of the updated CMA study may shed more light on this, but given the relatively few cases of brain cancer among Westlake workers, a study limited to that facility would resolve neither the issue of whether VCM exposure increases the risk of brain cancer nor the question of whether the brain tumors there are work-related. There is no way to determine whether a small cluster of an uncommon, but not rare, tumor is more than a chance occurrence, especially in the absence of a known association between an exposure and the tumor. VVV t>00oi420g Page 3 - Mr. Thomas G. Grumbles, C.I.H. This letter constitutes our official response to your request for a health hazard evaluation. It should be posted in a prominent place accessible to affected employees for a period of 30 days. Should there be any additional questions, I can be reached at ( 513) 841-4386. I would be happy to talk wi any employee or any company or e mployee representative. Mitchell Singal, M.Dtf* M.P.H. Chief Medical Section Hazard Evaluations and Technical Assistance Branch Division of Surveillance, Hazard Evaluations, and Field Studies VVy 00I4206 Questionnaire Business Name \l~Ls~VA, CA\m\Cal Address: Jy5o (OftKJk&Wilie* &Q 5o4e.tl0 (_1 X51L, i Xt-t'rto-tS bc&3'2. 1. Do you currently (or in the past two years) manufacture, distribute, import, or export any of the below listed chemicals? (include drop shipments and broker/forwarding) XYes No 2. If the answer to question 1 is yes, please check those chemicals that you handle as listed below. Precursor Chemicals Essential Chemicals Anthranilic acid and its salts. _____ Benzyl cyanide. _____ Ephedrine, its salts, optical _____ isomers, and salts of optical isomers. Ergonovine and its salts. _____ Ergotamine and its salts. _____ N-Acetylanthranilic acid _____ and its salts. Norpseudoephedrine, its ____ p salts , optical isomers and salts of optical isomers. Phenylacetic acid and its salts. Phenylpropanolamine, its ____ _ salts, optical isomers, and salts of optical isomers. Piperidine and its salts. ____ _ Pseudoephedrine, its salts, ____ optical isomers, and salts of optical isomers. 3,4-Methylenedioxyphenyl-2- propanone (piperonyl methylketone). Acetic anhydride. Acetone. Benzyl chloride. * Ethyl ether. Hydriodic acid. PotassiuD permanganate 2-Butanone (or Methyl Ethyl Ketone or MEK.) Toluene 3. Please check each of the business activities you are engaged in pertaining to the chemicals checked in the above list. Manufacturer Importer Efcoorter Distributor/Vjholesaler Retailer * Broker/Forwarder Other (Please List) VVV 000014207 4. Do you currently (or in the past two years) manufacture distribute, import, or export tableting or encapsulating machines. Yes_______________ No X____ 5* Please provide the name, title, and telephone number of a contact person. Name and Title Torrx (pfionftVA&S Telephone | `b '~5>8~3H4 5 VVV 000014-208 TO: R. D. Gamblin Interoffice Communication FROM: DATE: SUBJ: T. G. Grumbles October 6, 1989 PROGRESS REPORT _\/lvT- / 1/ A Below is a summary of the Biomedical and Environmental Affairs Department's activities for the last two weeks. 1. TGG made a presentation to the Annual Surfactants Meeting regarding environmental challenges in the future and Vista Environmental Policy. 2. Consulted with Marketing Administration on the content of communication with Canadian customers regarding the Canadian Environmental Protection Act Domestic Substances List and the status of Vista products. 3. Consulted with Purchasing about communicating with our PVC ingredient suppliers regarding the same. Met with Legal to prepare for Environmental Awareness Training for PED and S & T groups. 5. Conferred with Lake Charles personnel concerning RCRA training and upcoming VCM plant audit. 6 . Conferred with S & T on upcoming auditing program. 7. Reactivated Environmental Engineering Standards Team. 8. Responded to LCA request to provide information on DEQ delaying actions on permit applications. 9. Participated in vinyl chloride rail/barge shipping options discussion. 10. 44 COEDS ordered MSDS's were sent out. 11. Revised 810-40 and LPA 140 MSDS's. 12. Prepared a new MSDS for N-500L. 13. JCL attended the Vinyl Environment meeting and minimization presentation companies. Institute Health, Safety, and organized a series of waste at that meeting by VI member JCL attended the annual Vinyl Chloride Safety Association meetineii^^y^aHHBSi was elected 1990 chairman of the VCSA. VW 000014209 R. D. Gamblin Memo October 6, 1989 Page 2 15. The CLER Communication Committee met with the E. Bruce Harrison Company to discuss the 1990 activity schedule. The 1990 budget for this activity has been set at $140M. 16. Scheduled Environmental Awareness Training with S&T Ex-Plant and PED. 17. JCL participated in a team to evaluate the need for R&D assistance on environmental compliance projects at the plants. A recommendation was made that R&D become involved in a number of areas to identify alternate technologies that might be used to reduce discharges of pollutants. 18. JCL attended the VI Technical Committee meeting. The VI is contemplating taking the position that the use of lead stabilizers be reduced to the extent feasible. The driving force is concern over lead in Municipal Solid Waste incinerator ash. The largest source of lead in MSW appears to be from discards of imported shoes. Wire and cable is not considered a component of MSW due to its semi-permanent applications and high recycle rate. T. G. Grumbles dlj vvv 0000l*210