Document 16bXgDL5ONZv5G8Zk6axGxa5

M bl J 1957 S P E C IF IC IN STRUCTIO N S TO E X P E R IM E N T A L S U B JE C T S 1. M aintain a confidential reco rd fo r D octor Kehoe of daily a ctiv itie s, fir s t indicating usual habits and m anner of life , and subsequently calling atten - . v tion to d ep artu res fro m u su al re g im e n , listin g such events a s illn e s s e s , la te hours, p a rtie s, unusual a c tiv itie s o r vacations from the reg im en s, , w hether enforced o r oth erw ise. 2 . M adntain a. d aily r e c o r d of ite m s o f food and b e v e r a g e s , o th e r than w a te r, consum ed. R ecord any a ccid en ts, e r r o r s , or om ission s that m ay influence sam p les and re su lts. That is , if any sam ple is lo st or p artially lo st or dam aged in any m a n n e r, a re p o rt of the c irc u m sta n c e should be m ade . v erb a lly and fo r the re co rd . 3 . C o llect duplicate sam p les of a ll item s of food, and of b ev erag es except w a te r, putting them to g eth er as one sam p le p er day, o r p e r m ea l, as d e s ire d . (When a la rg e volum e of any b ev e ra g e is involved, k e e p .it se p a ra te fro m the food sam p le. ) K eep a ll co n tain ers in paper b ag s, b efo re and a fte r u se , to avoid con tam in ation with d u st. M ark a ll sa m p le s c a re fu lly with nam e and date. 4 . C o llect a duplicate sam p le, daily, of a ll w ater consum ed, taking an equivalent am ount, a s consu m ed . M a rk c a re fu lly with nam e and d ate. 5 . C o lle ct u rin e in 24-h o u r sam p les in gallon ju g s, using no p re se rv a tiv e . E x e r c is e g re a t c a re ag a in st any p o ssib le contam ination of the sam p les by w ashing the hands and drying them c a re fu lly b e fo re handling the co n ta in er, and by rem oving the co n tain er fro m the paper bag only in a scru p u lou sly clea n p la ce f r e e of d u st. K eep ju g in pap er bag ex cep t when in u se . R e co rd any lo s s e s o r fa ilu re s to c o lle c t sa m p les. D aily co lle ctio n is to begin a t 8:00 A .M . , voiding into the co n ta in er a t that hour, thus com p leting the sam p le, th en obtaining a new co n ta in e r. M ark each sam p le with the day and hour e,, g . 8 :0 0 A . M . , Ju n e 10 to 8 :00 A . M . , Ju n e 11. 6. C o lle ct each stool in a sep a ra te clean ja r , m arkin g the date and hour on each sam ple. 7 . K eep a ll sa m p le s c a re fu lly w here th ey cannot be ta m p ered with ardw here they w ill not be broken m ech an ically or by fre e z in g , and w here they w ill not be exposed to dust o r d irt, o r su b je cted to e x c e s s iv e ly hot o r fre e z in g te m p e ra tu res. 8 . R ep o rt to the p erso n d esign ated fo r c e rta in m ic ro sc o p ic blood exam in ation s. 9. R ep o rt any and a ll illn e s s o r in d isp o sitio n to the p h y sician assig n ed to your m ed ica l su p erv isio n and tak e no m ed icatio n without in stru c tio n s. If m e d ic a tion is au thorized , p re se rv e a duplicate of each dose fo r a n a ly sis. 10. C ertain m ed ical and physiological ob serv ation s w ill be m ade reg u larly , and c e rta in o th ers fro m tim e to tim e , on Satu rday m o rn in g s. O ther a c tiv itie s should be c a r r ie d out on a fle x ib le sched ule so that a s m uch of Satu rday 2- - m orning a s m ay be re q u ired w ill be fr e e fo r th ese p u rp o ses. R ep ort to the p hysician assign ed to your m ed ical su p ervision each Saturday m orning. 1 1 . C o n fer with M r. R o b e rts , o r the p h y sicia n assig n ed to your m ed ica l su p e r v ision . or to D r. Kehoe over any m a tte rs of proced u re or policy that cause d ifficu lty of any kind. In th e ir a b sen ce consu lt M r. C holak.