Document 15Q3gxR2yO09K1Ez8bDjznbpX

\ .v October 3 1969 Dr. A. R. Glasgow Chief of Reference Standards Section Residue Chemistry Drench . Division of PsstioLdns Pood oml Drug Administration Washington, V, C. 2023k Dear Dr. Olosgowi One pound samples of our Aroclora 125** find 1260 are being forwarded to you and to Mr. Vincent Sudlalc at the Atlanta Toxicological Branch today. Perhaps It will be of interest to mention that In iy62 one of our consulting laboratories udtei-i..ir.cu the oral IDf0 In rats* of /.roclor 1254 to 1.0 creator than 13 grams per I'.ilegron when administered undiluted vein- four groups of mixed sex animals weighing between 200-253 grama and administered at doses of 7.9'*, iO.O, 12.6, and 15.6 respectively for the individual groups, `fha oral BD50 was calculated as 11.9 g/kg with Units of 10.47 to 13.krj g/kg. Zn the casa of Aroolor 1260, a 50# solution In corn oil developed data loading to a calculated LD50 of 10.0 g/itg with lower and upper limita of 6.6 and 11.6 g/kg. X have enclosed cunmarlaa of recent data wo have received from Industrial Elo-Tost Lai-orotcrles In Chicago. The surcssries Indicate the yo-Oay Interim recults of two year chronlo feeding studies to dogs of Aroclor 1254 and 1260. A oeconfl enclosure lo the summary showing the status of three generation rat reproduction studies on these materials begun In Kay. We also have underway two year oral studies In rata. V'c udded 333 extra animals to this stuuy to allow itocrlflco of some animals at three months, six months and one year. MOMS 089199 Dr. a. R. dlasgow October 3 1969 Page Two A verbal report on the 90 Cay sacrifices Indicates that there were no noasuralilo offcctu as indicated by the usual parameters. A written Interim report will be received when the micro pathology has been completed. Z have token the liberty of sending a copy of this letter to you to Kr. Sedlak In the Atlanta Branch. Wo will be Interested in learning of the results of your proposed toxicological testing. Sincerely, Elmer P, Wheeler Manager, Environmental Health EPWtJu c.c. b.c. Jock D. Early Vincent r.oillalt/ R. E. Keller 1/ W. R. Richard HONS 009200