Document 15KojG95kJ3ymNnajvjaJGE5q

PRINTOUT FOR GARY JONES ORDER NUMBER 660627-135259-WIZ -001-001 PAGE 1 SET 4 WITH 385 OF 365 ITEMS ITEM 1 ACCESSION NUMBER 2142 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT PAPER FINAL DRAFT CRITERIA DOCUMENT FOR VINYL CHLORIDE AUTHOR/AFFILIATION NONE Inone; ORIGIN EPA DATE ABSTRACT 1962, JANUARY HEALTH EFFECTS BRANCH/OFFICE OF DRINKING WATER DISCUSSES PHYSICAL AND CHEMICAL PROPERTIES,HUMAN EXPOSURE,PHARMACOKINETICS,HEALTH EFFECTS,RISK ASSESSMENT AND MCL UNDER CONSIDERATION FOR VCM. DESCRIPTORS ******* VCM5DRINKING WATER {HUMANS? EFFECTS {CARCINOGENICITY{CHRONIC {TERATOGENICITY{MUTAGENICITY? PHARMACOKINETICS; HELD TERMS REVIEW YEAR MCL;MAXIMUM CONTAMINANT LEVEL? 1990 ITEM 2 ACCESSION NUMBER 2141 FILE LOCATION GEN OOCUMENT TYPE EPA REPORT TITLE OR SUBJECT HEALTH EFFECTS ASSESSMENT FOR VINYL CHLORIOE AUTHOR/AFFILIATION NONE,NONE; ORIGIN EPA,REPORT N0.PB86-134475? DATE 1964, SEPTEMBER ABSTRACT OOCUMENT REPRESENTS A BRIEF,QUANTITATIVELY ORIENTED SCIENTIFIC SUMMARY OF HEALTH EFFECTS DATA. IT HAS DEVELOPED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE TO ASSIST THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE IN ESTABLISHING CHEMICAL-SPECIFIC HEALTH-RELATED GOALS OF REMEDIAL ACTIONS. IF APPLICABLE,CHEMICAL-SPECIFIC SUBCHRONIC AND CHRONIC TOXICITY INTERIM ACCEPTABLE INTAKES ARE DETERMINED FOR SYSTEMIC TOXICANTS, OR Ql* VALUESARE DETERMINED FOR CARCINOGENS FOR BOTH ORAL AND INHALATION ROUTES. A Ql* MAS DETERMINED FOR VINYL CHLORIDE BASEO ON BOTH ORAL AND INHALATION EXPOSURE.VINYL CHLORIOE FOLLOWING INHALATION EXPOSURE HAS BEEN SHOWN TO BE CARCINOGENIC IN HUMANS,RATS,MICE AND HAMSTERS. USING DATA FOR TUMOR INCIDENCE IN RATS, A Ql* FOR HUMANS OF 2.5X10-2 CMG/KG/DAYJ-l WAS ESTIMATED. NO DATA ARE AVAILABLE CONCERNING ORAL EXPOSURE IN HUMANS AND CANCER RISK. ON THE BASIS OF TOTAL TUMORS IN FEMALE RATS FED VINYL CHORIDE-CONTAINING DIETS, A HUMAN Ql* OF 2.3 (MG/KG/DAY)-l NAS ESTIMATED FOR ORAL EXPOSURE. DESCRIPTORS ******* CARCINOGENICITY;VCMI RISK ASSESSMENT;EFFECTS;RATS? REVIEW YEAR 1990 ITEM 3 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN 2121 GEN JOURNAL APPLICATION OF THE "FILTER MODEL" TO A RISK ASSESSMENT FOR VINYL CHLORIDE OLSON CS,EPA{SCHAEFFER DJ,NONE? J OF TOXICOLOGY AND ENVIRONMENTAL HEALTH,VOL 17 PP.1-22J BFG52691 20898002 I PRINTOUT FOR GARY JONES ORDER NUMBER 660827-135259-WIZ -001-001 PAGE 2 SET 4 NITH 365 OF 365 ITEMS DATE ABSTRACT DESCRIPTORS REVIEW YEAR 1986 THE FILTER MODEL WAS USEO TO ESTIMATE THRESHOLDS FOR THE INDUCTION OF CANCER FROM MANY DOSE-RESPONSE SETS FOR INFLATION AND INGESTION EXPOSURE TO VINYL CHLORIDE FOR RAT AND INHALATION EXPOSURE FOR MOUSE. ESTIMATES FOR A VARIETY OF EW-P01NT COMBINATIONS WERE LOG-NORMALLY DISTRIBUTED OVER ABOUT 2 DECADES FROM ABOUT 1 TO 100 PPM FOR INHALATION EXPOSURE TO RAT AND 0.1 TO 30 PPM FOR MOUSE. WHEN THE DATA IS TRANSFORMED TO "OOSE" (MILLIGRAMS PER KILOGRAM BODY HEIGHT PER OAT) THE ESTIMATES FOR INHALATION AND INGESTION EXPOSURE A) ALSO FOR RAT AND MOUSE ARE SIMILAR. ESTIMATES FOR DIFFERENT EXPERIMENTS CARRIED OUT FOR DIFFERENT DURATIONS OF TIME (SINGLE EXPOSURE TO 1 YR) ARE COMPARABLE. SINCE THE THRESHOLD IS AH INTRINSIC PROPERTY OF THE BIOLOGICAL SYSTEM* THE ESTIMATE. EVEN FROM A PROTOCOL FOR SHORT EXPOSURE AND LESS THAN LIFETIME OBSERVATION. CAN BE USED DIRECTLY IN A RISK ASSESSMENT AS THE MAXIMUM SAFE DOSE. ******* VCMJRISK ASSESSMENT;CARCINOGENICITY.EFFECTS.HUMANJRAT.MICE; 1995 ITEM 4 ACCESSION NUMBER 2116 FILE LOCATION GEN / OOCUMENT TYPE LITERATURE SEARCH TITLE OR SUBJECT CITATIONS FROM THE LIFE SCIENCES COLLECTION DATABASE--VINYL CHLORIDE: TOXICOLOGY (1976-1965) AUTHOR/AFFILIATION NONE,NONE; ORIGIN NTIS,PB86-856119; DATE 1966 ABSTRACT THIS BIBLIOGRAPHY CONTAINS CITATIONS CONCERNING THE TOXICITY OF VINYL CHL0RI0E AND POLYVINYL CHLORIDE FOLLOWING SHORT AND LONG TERM EXPOSURES. METABOLISM. CARCINOGENICITY. AND TERATDGENITIC POTENTIAL OF THESE SUBSTANCES ARE CONSIDERED. METHODOLOGY TO QUANTITATE THEIR PRESENCE IN ATMOSPHERIC DUST AND BODY TISSUES APE DISCUSSED. OCCUPATIONAL HAZARDS ARE ALSO NOTED. (THIS UPDATED BIBLIOGRAPHY CONTAINS 231 CITATIONS. 11 OF WHICH ARE NEW ENTRIES TO THE PREVIOUS EDITION. ) DESCRIPTORS ******* VCMJPVC.HUMAN!EFFECTS,ANGIOSARCOMA;CARCINOGENICITYACUTE(MICE>RATS; RABBITS; REVIEW YEAR 1990 ITEM 5 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AF FILIATION ORIGIN DATE ABSTRACT 2110 GEN PUBLICATION TRANSIENT HYPOXEMIA IN FIREMEN FOLLOWING INHALATION OF SMOKE GENOVESI MG.NONEpTASHKIN DP.NONE(CHOPRA S.NONE.MORGAN M.NONE5 MC ELROY C.NONE; NONE,VOL 71 NO.4 PP.441-449; 1977, APRIL MILD TO MODERATELY SEVERE HYPOXEMIA WAS DOCUMENTED IN 19 OF 21 MOSTLY ASYMPTOMATIC FIREMEN WHO WERE EXPOSED TO DENSE SMOKE CONTAINING POUVINYICHLORIOE AND OTHER PULMONARY IRRITANTS. THE HYPOXEMIA HAS TRANSIENT,WITH NEARLY COMPLETE REVERSIBILITY WITHIN 24 HOURS. SUBSEQUENT TESTS FOR PULMONARY FUNCTION ONE MONTH LATER DEMONSTRATED THAT THIS TRANSIENT HYPOXEMIA MAS NOT RELATED TO PREVIOUS UNDERLYING PULMONARY DISEASE. THE POTENTIAL FOR SERIOUS COMPLICATIONS OF INHALATION OF SMOKE,PARTICULARLY SMOKE FROM BURNING PLASTICS, IS HEIGHTENED BY THE FREQUENT LACK OF SYMPTOMS ASSOCIATED WITH THIS TYPE OF EXPOSURE,DESPITE THE DEVELOPMENT OF MODERATELY SEVERE HYPOXEMIA IN ADDITION TO CARBOXYHEMOGLOBINEMIA. PRECAUTIONARY MEASURES SHOULD INCLUDE UNINTERRUPTED USE OF AN EFFECTIVE BREATHING APPARATUS BY FIREMEN EXPOSED TO SMOKE AND TO NOXIOUS FUMES AND TEMPORARY 20898003 'A \n O 1 PRINTOUT FOR GARY JONES ORDER NUMBER 060827-135259-WIZ -001-001 PAGE 3 SET 4 WITH 385 OF 385 ITEMS descriptors HELD TERMS REVIEW YEAR OXYGEN SUPPLEMENTATION,EVEN IN ASYMPTOMATIC FIREMEN, FOLLOWING EXPOSURE TO DENSE SMOKE. WHILE THE AUTHORS CONTEND THAT LARGE QUANTITIES OF PVC WERE BURNED, NO DOCUMENTATION IS PROVIOED. ALSO NOTE THE EDITORIAL BY WEBSTER < 1977--AN821081. **** combustion;toxicity}thermal oecomposition}Pvc;fires;firefightinq;human;effects;acute}Blooo; CHESTS OXYGENjHYPOXEHIA 1995 ITEM 6 ACCESSION NUMBER 2109 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT RESPIRATORY STATUS OF LOS ANGELES FIREMEN: ONE-MONTH FOLLOW-UP AFTER INHALATION OF DENSE SMOKE AUTHOR/AFFILIATION TASHKIN OPNONE,GENOVESI MG,NONE(CHOPRA,NONE{COytSON A,NONE} SIMMONS M,NONE} ORIGIN NONE,VOL 71 NO.4 PP.445-449} OATE 1977, APRIL ABSTRACT STANDARDIZED RESPIRATORY QUESTIONNAIRE AND OETAILED PULMONARY FUNCTION TESTS WERE ADMINISTERED TO 21 LOS ANGELES FIREMEN ONE MONTH FOLLOWING EXPOSURE TO THE COMBUSTION PRODUCTS OF POLYVINYLCHLORIDE, WHICH HAD PRODUCED TRANSIENT HYPOXEMIA IN 19 OF THE FIREMEN. THE RESULTS OF THESE STUDIES WERE COMPARED WITH THOSE OBTAINED IN A SAMPLE OF NONFIREMEN RESIDING IN THE LOS ANGELES AREA WHO WERE MATCHED BY COMPUTER NITH THE FIREMEN FOR ANTHROPOMORPHIC CHARACTERISTICS AND SMOKING STATUS. THE FREQUENCY OF RESPIRATORY SYMPTOMS,THE RESULTS OF SPIROMETRIC AND PLETHYSMOGRAPHIC STUDIES, AND THE SINGLE-BREATH NITROGEN WASHOUT WERE SIMILAR IN THE FIREMEN, COMPARED NITH THE MATCHED SAMPLE,WHEREAS CLOSING VOLUME NAS HIGHER IN THE MATCHED CONTROLS. THESE FINDINGS SUGGEST THAT ALTHOUGH FIGHTING FIRES MAT RESULT IN ACUTE PULMONARY INJURY SECONDARY TO DISCRETE EPISODES OF INHALATION OF SMOKE.IT DOES NOT APPEAR TO PREOISPOSE TO THE DEVELOPMENT OF CHRONIC RESPIRATORY SYMPTOMS OR CHRONIC FUNCTIONAL RESPIRATORY IMPAIRMENT. WHILE THE AUTHORS CONTEND THAT LARGE QUANTITIES OF PVC WERE BURNED,NO DOCUMENTATION IS PROVIOED. ALSO NOTE THE EDITORIAL BY WEBSTER 11977--ANI2108). DESCRIPTORS #***#* COMBUSTION}TOXICITY{THERMAL DECOMPOSITION}PVC}FIRES}FIREFIGHTING} HUMANSEFFECTSIACUTES EPIDEMIOLOGY} HELD TERMS CHEST} REVIEW YEAR 1995 ITEM 7 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 2100 GEN PUBLICATION SMOKE AND FIRE--1977 < WEBSTER JR,NONE, NONE,VOL 71 NO.4 PP.43B} 1977, APRIL IN THEIR EDITORIAL COMMENTS ABOUT THE PAPER BY GENOVESI ET AL C1977) THE AUTHORS STATE: ALL PHYSICIANS SHOULD BE AWARE OF THESE TWO POTENTIAL PROBLEMS WHEN TREATING VICTIMS OF FIRES,MAKING SURE THAT OXYGEN IS ROUTINELY ADMINISTERED AS SOON AS POSSIBLE AND THAT THE PATIENT IS OBSERVED CAREFULLY FOR (1) CEREBRAL COMPLICATIONS OF THE INHALATION OF CARBON MONOXIDE AND (2) THE RESPIRATORY INSUFFICIENCY WHICH MAY ENSUE AFTER A DECEPTIVELY TRANQUIL INTERVAL. CARDIAC, AS WELL AS PULMONARY, SYSTEMS ARE AFFECTEO BY THE ALTERED PHYSIOLOGY WHICH RESULTS FROM THIS TOXIC EXPOSURE, ESPECIALLY DURING EARLY/fcRITICAL PERIODS. TECHNIQUES FOR EVALUATION AND TREATMENT OF / 20898004 BFG52693 I ..-IDROOS PRINTOUT FOR GARY JONES ORDER NUMBER 660827-135259-WIZ -001-001 PAGE 4 SET 4 NITH 365 OF 365 ITEMS THE ADULT RESPIRATORY DISTRESS SYNDROMENONCARDIAC PULMONARY EDEMA* CARDIAC FAILURE*AIRWAY INJURY* SEPSIS*LACTIC ACIOOSIS DUE TO CARBOXYHEMOGLOBINEMIA WITH TISSUE HYPOXIA AND SO FORTH. REGARDING THE TASHKIN ET AL (1977) ARTICLE THEY NOTE VARIANCE WITH PREVIOUS STUDIES BUT NOTE THAT FIREFIGHTERS HAVE A LON MORBIOITY. DESCRIPTORS **** COMBUSTION;TOXICITY;THERMAL DECOMPOSITION5PVC;FIRE5FIREFIGHTINGSHUMAN; EFFECTS;ACUTE5 EPIDEMIOLOGY; HELD TERMS therapy;chest;northmestern univ meoical school{northwestern univ; KWIC INDEX NUMBER 04154 REVIEW TEAR 1995 ITEM 8 accession number 2107 FILE LOCATION GEN DOCUMENT TYPE PROCEEDINGS TITLE OR SUBJECT EFFECTS UPON FIRE FIGHTERS AFTER EXPOSURE TO THE PROOUCTS OF DECOMPOSITION OF POLYVINYL CHORIDE AND (2) TOXICITY IN THE FIRE FIGHTER'S ENVIRONMENT AUTHOR/AFFILIATION DYER rf,none?esch vh*none; ORIGIN NONE,FOURTH SYMPOSIUM ON THE HEALTH AND HAZARDS OF THE FIRE SERVICE (WASHINGTON,Q.C.)? DATE 1977. APRIL 17-19 ABSTRACT DYER REPORTS EFFECTS IN FIREFIGHTERS WHICH THET ATTRIBUTE TO PVC DECOMPOSITION PRODUCTS. HOWEVER* THE SYMPTOMS THEY DISCUSS ARE ONES WHICH CAN BE ATTRIBUTED TO COMBUSTION PRODUCTS OF COMMON NATURAL MATERIALS. ESCH STATES CONCERNS OVER THE TOXICITY OF PVC. DESCRIPTORS ******* CQKBUSTION?TQXICITY.THERMAL DECOMPOSITION;FIRESJHUMANiEFFECTSJ ACUTE;PVC*. HELD TERMS firemeniiaff; REVIEW YEAR 1995 ITEM 9 ACCESSION NUMBER 2086 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT OCCUPATIONAL EXPOSURE AND BRAIN TUMORS AUTHOR/AFFILIATION MOSS AR.UNIV OF CALIFORNIA? ORIGIN J OF TOXICOLOGY AND ENVIRONMENTAL HEALTH,VOL 16 PP.703-711? DATE 1985 ABSTRACT EPIDEMIOLOGICAL EVIDENCE OF AN OCCUPATIONAL RISK OF BRAIN CANCER HAS BEEN REPORTED IN FOUR INDUSTRIES WHERE CHEMICAL EXPOSURES ARE LIKELY, MOST RECENTLY IN A SERIES OF PROSPECTIVE STUDIES IN THE PETROCHEMICAL INDUSTRY. HOWEVER, ONLY IN TOE CASE OF VINYL CHLORIDE EXPOSURE HAS AN OCCUPATIONAL CENTRAL NERVOUS SYSTEM CARCINOGEN BEEN IDENTIFIED. THIS REPORT REVIEWS THE CONVERGENCE OF EPIDEMIOLOGICAL AND LABORATORY EVIDENCE THAT ESTABLISHED THE OCCUPATIONAL CARCINOGENICITY OF VINYL CHLORIDE, AND DISCUSSES IN OETAIL TOE CURRENT EVIDENCE FOR AN OCCUPATIONAL RISK OF BRAIN TUMORS IN THE PETROCHEMICAL INDUSTRY. .DESCRIPTORS ******* BRAIN?TUMORSJVCMJHUMANJEFFECTS? 'HELO TERMS GLIOMAS? REVIEW YEAR 1995 ITEM 10 ACCESSION NUMBER 2076 3FG 52694 20898005 I PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-WIZ -001-001 PAGE 5 SET 4 WITH 385 OF 385 ITEMS ^ FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ******* HELD TERMS REVIEW YEAR GEN * CORR KORCSEAL PETITION FOR LISTING WITH NEN YORK CITY(1984-19861 ROBERTS BL.NONE; NONETO HOUSING & DEVELOPMENT-ADMIN. CITY OF NEW YORK; 1985* JANUARY 24 & THIS DOCUMENT CONTAINS DATA*SUBMITTED TO NEW YORK CITY AND OTHER PERTINENT DOCUMENTS pvc; pvc uallcovering;koroseal;u.s. testing co; 1995 ITEM 11 ACCESSION NUMBER 2070 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT REPORT , EVALUATION OF THE TOXIC POTENTIAL OF MATERIALS--TOXICOLOGICAt INTERPRETATION OF ANALYSIS OF THERMOLYSIS PRODUCTS s* AUTHOR/AFFILIATION NONE.NONE 5 ORIGIN NONE DATE 1984. NOVEMBER 30 ABSTRACT THIS FRENCH STUDY EVALUATES THE TOXIC POTENTIAL OF MATERIALS IN CONFINED ATMOSPHERES AS MIGHT BE ENCOUNTERED ON SUBMARINES DURING A FIRE. RATS HERE EXPOSED TO PURE GASES (INCLUDING HCL) AND COMBUSTION GASES FROM VARIOUS ELECTRIC CABLES AND PAINT COATINGS FOR 15 MINUTES IN A 560 L CHAMBER. IN THE CASE OF HCL.THEY FOUND THAT THEY COULD NOT MAINTAIN THE DESIRED LEVELS AND WENT TO A 1.25 LITER CHAMBER. USING THE NOH DEFUNCT LOGIC OF ALARIE.THEY DETERMINED THAT THE RD50 (ED50) FOR HCL TO BE 43 PPM AND USED THIS AS THE CRITICAL TOXIC CONCENTRATION.CTCI. IN PART III SEC.1.7 THE AUTHORS STATE THAT 'THE CABLES ACOME PRESENT THE HIGHEST RISK OUE TO THE PRESENCE OF HCL ORIGINATING FROM PVC.* DESCRIPTORS ******* PVC5HCL.COMBUSTIONJTOXICITY JRATSEFFECTS> HELD TERMS RD50.CENTERFOR TECHNICAL SUBMARINE STUDIES A RESEARCH (FRANCE ); COMMENTS RKH(86) THESE AUTHORS ERRONEOUSLY USE THE RD50 AS THE CTCI.STUDIES BY POTTS AND LEDERER HAVE SHOWN THAT THIS IS NOT VALID.FURTHERMORE. THE FAA AND VI PRIMATE STUDIES SHOW THAT THE CTCI FOR HCL IS FAR HIGHER AND THAT HCL IS NOT INCAPACITATING. REVIEW YEAR 1995 ITEM 12 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE ABSTRACT 2068 GEN JOURNAL EXPOSURE TO VINYL CHLORIDE AND ANGIOSARCOMA OF THE LIVER:A REPORT OF THE REGISTER OF CASES FORMAN D,NONE;BENNETT B>ICi;STAFFORD J.SAME.OOLL R,NONE5 BRITISH J OF INDUSTRIAL MEDICINE.VOL 42 PP.750-753; 1985 THE ASSOCIATION OF PLASTIC MANUFACTURERS IN EUROPE MAINTAINS A REGISTER OF ALL CASES OF ANGIOSARCOMA OF THE LIVER (ASL) RESULTING FROM EXPOSURE TO VINYL CHLORIOE MONOMER (VCM).THIS REGISTER HAS RECORDED ALL KNOWN VCM RELATED CASES OF THE DISEASE WORLOWIOE THAT HAVE BEEN HISTOLOGICALLY CONFIRMED.ALTHOUGH LIKELY TO BE INCOMPLETE.IT IS THE MOST COMPREHENSIVE TABULATION OF SUCH CASES AVAILABLE AND.BY THE END OF 1984.118 MEN HAD BEEN REGISTERED .THE INFORMATION FROM BFG52695 20898006 ! T mi it r ''n r.py mt|r7 I w ; A. ,R^R0rV7 PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-WIZ -001-001 PAGE 6 SET 4 WITH 385 OF 385 ITEMS DESCRIPTORS REVIEW YEAR ANALYSIS OF THE CASES CURRENTLY ON THE REGISTER IS USED TO MAKE AN APPROXIMATE PROJECTION OF THE NUMBER OF CASES TO BE EXPECTED IN THE FUTURE.THE CONCLUSION FROM THIS PROJECTION IS THAT THE INDUSTRY IS REACHING THE HALFWAY STAGE IN THE APPEARANCE OF VCM RELATED ASL. ******* VCM{ANGIOSARCOMA{CARCINOGENICITYiHUMAN5EFFECTSLIVER * 1990 ITEM 13 ACCESSION NUMBER 2067 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT AUTHOR/AFFILIATION CARCINOGENICITY OF FORMALDEHYDE AND HYDROGEN CHLORIDE IN RATS SELLAKUMAR AR,N0NE5SNY0ER CA,NONE5SOLOMON JJ,N0NE5ALBERT RE, NONE; ORIGIN TOX AND APPLIED,VOL 81 PP.401-4065 DATE 1985 ABSTRACT PREVIOUS STUDIES IN THIS LABORATORY HAVE SHOWN THAT THE COMBINED EXPOSURE OF HYDROGEN CHLORIDE (HCL) AND FORMALOEHYOE VAPORS (HCHO) ELICITED A SIGNIFICANT INCIDENCE OF NASAL CANCER IN RATS.IN STUDIES PERFORMED ELSEWHERE,IT HAS BEEN DEMONSTRATED THAT EXPOSURE TO FORMALDEHYDE ALONE INDUCED A HIGH NASAL CANCER RESPONSE IN RATS. WE WISHED TO DETERMINE WHETHER CONCURRENT EXPOSURE OF HYOROGEN CHLORIDE WOULD ENHANCE THE TUMORIGENIC EFFECTS OF FORMALDEHYDE .TWO EXPOSURE TECHNIQUES WERE USEO.IN ONE HYDROGEN CHLORIDE AND FORMALDEHYDE WERE PREMIXED AT HIGH CONCENTRATIONS BEFORE ENTRY INTO THE EXP05URE CHAMBERS IN ORDER TO MAXIMIZE THE FORMATION OF REACTIVE ALKYLATING AGENTS.IN THE SECOND THE HYDROGEN CHLORIDE AND FORMALDEHYDE WERE INTRODUCED SEPARATELY INTO THE EXPOSURE CHAMBER.APPROPRIATE CONTROL EXPOSURES CONSISTING OF FORMALDEHYDE ALONE OR HYOROGEN CHLORIDE ALONE OR AIR ALONE WERE ALSO PERFORMED.THE RESULTS SHOW THAT NASAL CANCER INCIDENCES WERE INDUCED IN ALL ANIMALS RECEIVING HCHO REGARDLESS OF CONCURRENT EXPOSURE TO HYDROGEN CHLORIDE.THE TUMORS WERE PREDOMINANTLY SQUAMOUS CELL TYPE ARISING FROM THE ANTERIOR PORTION OF THE NASAL CAVITY.THIS STUDY DEMONSTRATES THAT HYDROGEN CHLORIDE DOES NOT APPRECIABLY INFLUENCE THE NASAL CARCINOGENICITY OF FORMALDEHYDE. DESCRIPTORS ******* HYDROGEN CHLORIDE;RATS5CARCINOGENICITY5PVC{COMBUSTION{TOXICITY5 EFFECTS? HELD TERMS INSTITUTE OF ENVIRONMENTAL MEOICINESSYNERGISMS REVIEW YEAR 1995 ITEM 14 ACCESSION NUMBER 2063 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT MODELING OF TOXICOLOGICAL EFFECTS OF FIRE GASES: IV. INTOXICATION OF RATS BY CARBON MONOXIDE IN THE PRESENCE OF AN IRRITANT AUTHOR/AFFILIATION HARTZELL GE,SOUTHWEST RESEARCH INSTITUTE{STACY HW,SAME5SWITZER WG,SAME{PRIEST DN.SAMEJ ORIGIN UNKNOWN DATE 1965 ABSTRACT THE AUTHORS FOUND THAT HCL IN THE PRESENCE OF CO DID NOT SIGNIFICANTLY EFFECT LETHALITY (LC50); HOWEVER,MORE CO WAS REQUIRED TO CAUSE 50V. INCAPACITATION IEC5Q) IN THE PRESENCE OF HCL.THIS WAS OBVIOUSLY THE RESULT OF THE RESPIRATORY DEPRESSION EFFECT OF HCL IN RODENTS.THE ANIMALS BREATHED LESS AND THEREFORE REQUIRED A HIGHER CONCENTRATION TO GET THE SAME EFFECT.THE AUTHORS SUGGESTED THAT ABOVE 400QPPM CO,HCL WOULD HAVE NO APPRECIABLE EFFECT. DESCRIPTORS ******* pvcjhcucarbon monoxide;effects;acute;rats;combustion;toxicity; HELD TERMS INCAPACITATION; 20898007 VO 0\ Vo <N <o 2 OQ I PRINTOUT FOR GARY JONES ORDER NUMBER B60827-135259-WIZ -OOl-OOI PAGE 7 SET A WITH 385 OF 385 ITEMS REVIEW YEAR 1995 ITEM 15 ACCESSION NUMBER 2059 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OH SUBJECT EVALUATION OF THE PULMONARY EFFECTS OF HCL USING C02 CHALLENGES IN GUINEA PIGS AUTHOR/AFFILIATION BURLEIGH-FLAYER H,UNIV OF PITTSBURGH?WONG KL,5AME?ALARIE Y.SAMEJ ORIGIN NONE,VOL 5 PP.978-985? DATE 1985 ABSTRACT ALARIE'S GROUP HAS EVALUATED THE PULMONARY TOXICITY OF HCL IN GUINEA PIGS USING THE C02 CHALLANGE METHOD.ANIMALS WERE EXPOSED TO 320,680,1040, AND 1380 PPM FOR 30 MINUTES.THE AUTHORS REPORTED IMPAIRMENT OF THE RESPIRATORY FUNCITON AND MORPHOLOGICAL INJURY IN THE AIRWAYS AND ALVEOLAR REGION.IN THE DISCUSSION THEY CONCLUDED THAT PULMONARY DAMAGE WAS LESS SEVERE WITH HCL GAS THAN PVC SMOKE AND SPECULATED THAT THIS WAS A RESULT OF THE HCL ABSORBED ON THE SOOT. DESCRIPTORS **** pvc;hcl;pulmonary function?effects?respiratory effects;guinea pigs; combustion;toxicity? HELD TERMS co2 challenge;animal model; COMMENTS RKHC85) THIS DIFFERS FROM OUR STUDIES WITH BABOONS IN THAT WE ARE NOT SEEING EVIDENCE OF SIGNIFICANT DEEP LUNG PENETRATIONS.ALSO AT SIMILAR DOSES THE BABOONS HAVE ALL SURVIVED WHILE SOME MORTALITY HAS BEEN NOTED IN GUINEA PIGS. REVIEW YEAR 1995 ITEM 16 ACCESSION NUMBER 2058 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT THE SEARCH FOR EXPIRATORY OBSTRUCTION IN MEAT WRAPPERS STUDIED ON THE JOB AUTHOR/AFFILIATION KRUMPE PE,NONE?FINLEY TN.HONE;MARTINEZ N.NONE, ORIGIN AMERICAN REVIEW OF RESPIRATORY DISEASE,VOL 119 PP.611-618; DATE 1979 ABSTRACT WE STUDIED THE RESPIRATORY HISTORY QUESTIONNAIRE RESPONSES AND MAXIMAL EXPIRATORY FLOW-VOLUME CURVES IN MEAT WRAPPERS AND CONTROL SUBJECTS WHO HAD WORKED 12 PLUS OR MINUS 3 YEARS AT THEIR OCCUPATION? ALL SUBJECTS REGULARLY CUT POLYVINYL CHLORIDE FILM WITH A HOT WIRE AND WERE THUS EXPOSED TO PYROLYSIS FUMES ON THE JOB. CHANGES IN THE GROUP OF WRAPPERS WERE NOT SIGNIFICANTLY DIFFERENT FROM THE CONTROL GROUPS WHEN STUDIED BY ANALYSIS OF VARIANCE.THE WRAPPERS' RESPONSES UNDER REFRIGERATED CONDITIONS WERE NOT DIFFERENT FROM THOSE STUDIED AT ROOM TEMPERATURE.OUR STUDY DOES NOT PRECLUDE THE POSSIBILITY THAT CERTAIN HYPERSENSITIVE PERSONS MAY DEVELOP BRONCHOSPASM AFTER EXPOSURE TO FUMES OF POLYVINYL CHLORIOE FILM.HOWEVER,DOCUMENTATION OF NORMAL BASELINE PULMONARY FUNCTION STUDIES AND THE LOW INCIDENCE OF REACTIVE BRONCHOSPASM AFTER ON-THE-JOB EXPOSURE TO POLYVINYL CHLORIDE PYROLYSIS FUMES ARGUE AGAINST THE PRESENCE OF A MAJOR RESPIRATORY HAZARD IN THIS OCCUPATION. .DESCRIPTORS **** combustion;toxicity;thermal decomposition;pvc;human?effects?lung? meat-wrappers asthma; REVIEW YEAR 1995 ITEM 17 ACCESSION NUMBER FILE LOCATION 2057 GEN 20Q98003 BFG5269'7 I i> > r ^ on BFG52698 PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-WIZ -001-001 PAGE 8 SET 4 WITH 385 OF 385 ITEMS DOCUMENT TYPE JOURNAL TITLE OR SUBJECT POLYVINYL CHLORIDE FILM THERMAL DECOMPOSITION PRODUCTS AS AN OCCUPATIONAL ILLNESS: 2.CLINICAL STUDIES AUTHOR/AFFILIATION BROOKS SM.UNIV OF CINCIWATi;VANDEPVORT RNONE{ ORIGIN J OF OCCUPATIONAL MEDICINEtVOL 19 NO.3; DATE ABSTRACT 1977, MARCH EXPOSURE TO AIR CONTAMINANTS EMITTED INTO THE MEAT WRAPPING ENVIRONMENT MAY PROOUCE ACUTE HEALTH EFECTS IN SOME INDIVIDUALS. THE EFFECTS RELATE PRIMARILY TO EYE,NOSE AND THROAT IRRITATION. INDIVIDUALS WITH BRONCHIAL ASTHMA AND OTHER TYPES OF CHRONIC OBSTRUCTIVE RESPIRATORY DISEASE MAY DEVELOP BRONCHSPASM AS THE RESULT OF EXPOSURE TO THE IRRITANTS EMITTED. DESCRIPTORS ******* combustion;toxicity;thermal decomposition;pvc;human;effects;lung; meat-wrappers asthma; REVIEW YEAR 1995 ITEM 18 ACCESSION NUMBER 2056 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT POLYVINYL CHLORIDE FILM THERMAL DECOMPOSITION PRODUCTS AS AN OCCUPATIONAL ILLNESS : 1. ENVIRONMENTAL EXPOSURES AND TOXICOLOGY AUTHOR/AFFILIATION VANDERVORT R>NONE{BROOKS SM.UNIV OF CINCINNATI; ORIGIN J OF OCCUPATIONAL MEDICINE,VOL 19 NO.3 PP.169-191; DATE 1977, MARCH ABSTRACT IN THE PROCESS OF CUTTING PVC FILM WITH A HOT-WIRE,AN AEROSOL OF DI-2-ITHYLHEXYL ADIPATE IS FORMED.IT IS POSSIBLE THAT SOME OF THE HYDROGEN CHLORIDE EMITTED ABSORBS TO AEROSOL PARTICLES OF DI-2-ETHYLHEXYL ADIPATE. DESCRIPTORS ******* combustion;toxicity;thermal decomposition;pvc;human;effects;luns; meat-wrappers asthma; REVIEW YEAR 1995 ITEM 19 ACCESSION NUMBER 2055 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT CONSIDERTI0N5 ON ETIOLOGIC FACTORS IN MEAT WRAPPERS' ASTHMA AUTHOR/AFFILIATION LILIS R.CITY UNIV OF NEW YORK; ORIGIN JAMA,VOL 238 NO.2 PP.129J DATE 1977, JULY 11 ABSTRACT IRRITATIVE RESPIRATORY SYMPTOMS AND THE MEAT WRAPPERS' ASTHMA SYNDROME HAVE GENERALLY BEEN THOUGHT TO BE ETIOLOGICALLY RELATED TO DECOMPOSITION PRODUCTS OF POLYVINYL CHLORIDE IPVC),SUCH AS HYDROCHLORIC ACID AND/OR MINUTE AMOUNTS OF PHOSGENE,AND NOT TO PVC ITSELF OR TO THE MONOMER VINYL CHLORIDE. DESCRIPTORS ******* COMBUSTION;TOXICITY{THERMAL DECOMPOSITION;PVC{HUMAN{EFFECTS{LUNG; MEAT-WRAPPERS ASTHMA; REVIEW YEAR 1995 ITEM 20 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE 2054 GEN JOURNAL 2083S009 J 2v J3SD10 > T PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-UIZ >001-001 PAGE 9 SET 4 WITH 365 OF 385 ITEMS TITLE OR SUBJECT RESPIRATORY HEALTH AND POLYVINYL CHLORIDE FUMES AUTHOR/AFFILIATION JONES RN.NONESHEILL H,SAME5 ORIGIN JAMA,VOL 237 NO.17 PP.1826; DATE ABSTRACT 1977, APRIL 25 IN 1975, ME COLLECTED DATA ON RESPIRATORY SYMPTOMS AND LUNG FUNCTION FROM 150 EMPLOYEES OF A SUPERMARKET CHAIN IN NEH ORLEANS.IN 1972 TO 1973, THE MANAGEMENT REPLACED MOST OF THE HOT-MIRE WRAPPING MACHINES WITH MACHINES EQUIPPED WITH MECHANICAL FILM CUTTERS (BUT THESE ARE FITTED WITH HOT PLATES TO SEAL THE FILM,AS ARE THE OLDER MACHINES.IN THIS STUDY POPULATION,JOB-RELATED SYMPTOMS WERE RARE AND MERE NOT ATTRIBUTABLE TO PVC EXPOSURE.ME ARE AMARE THAT THESE DATA MAY NOT APPLY TO OTHER MORKING POPULATIONS USING DIFFERENT MACHINERY AND MORK PRACTICES. DESCRIPTORS **** combustion;toxicity;thermal decomposition;pvc;human;effects; meat-mrappers asthma;lung; HELD TERMS TULANE UNIV REVIEW YEAR 1995 ITEM 21 ACCESSION NUMBER 2053 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT RESPIRATORY ILLNESS IN MEAT WRAPPERS AUTHOR/AFFILIATION FALK HOEPT OF HEALTH EDUCATION AND WELFARE5PORTNOY B,UNIV OF TEXAS; ORIGIN JAMA,VOL 235 NO.9 PP.915-943; DATE 1976, MARCH 1 ABSTRACT A QUESTIONNAIRE SURVEY MAS ADMINISTERED IN 152 HOUSTON, TEXAS SUPERMARKETS TO ASSESS THE PREVALENCE OF RESPIRATORY SYMPTOMS IN MEAT WRAPPERS EXPOSED TO THE THERMAL DECOMPOSITION FUMES OF PVC FILM WRAP AND TWO SUPERMARKET CONTROL GROUPS (CHECKERS 8 MEAT CUTTERS).MEAT WRAPPERS HAD INCREASED RESPIRATORY SYMPTOMATOLOGY, WITH 12X OF SMOKING WRAPPERS (VERSUS 6X AND ZX OF CONTROLS) AND 5X OF NON-SMOKING WRAPPERS (VERSUS OX AND OX OF CONTROLS) HAVING MULTIPLE RESPIRATORY SYMPTOMS. IT IS PROBABLE THAT A LARGE NUMBER OF HEAT WRAPPERS HAVE MILD RESPIRATORY SYMPTOMS WITH SOME PROGRESSING TO MORE SEVERE RESPIRATORY IMPAIRMENT AND/OR CLINICAL ASTHMA. PREVENTIVE MEASURES TO REDUCE OR ELIMINATE EXPOSURE TO FILM WRAP FUMES, SUCH AS USE OF 8LADE MACHINES OR DESCRIPTORS COMMENTS IMPROVED VENTILATION, NEED TO BE INSTITUTED. **** combustion;toxicity;thermal decomposxtion;pvc;human;effects; meat-wrappers asthma;lung; RKH(85) ALSO REFER TO AN-109 FOR THE PAPER. REVIEW YEAR 1995 ITEM 22 ACCESSION NUMBER 2052 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT MEAT-WRAPPERS*S RESPIRATORY TRACT DISEASE AUTHOR/AFFILIATION HUSSEY hh,none; ORIGIN JAMA,VOL 235 NO.9 PP.943; DATE 1976, MARCH 1 ABSTRACT PREVENTION OF AN ILLNESS THAT HAS PROVED TO BE SURPRISINGLY PREVALENT MIGHT INCLUDE THE INSTALLATION OF PROPER VENTILATING EQUIPMENT AND USE OF LOWER-TEMPERATURE CUTTING WIRES.HOWEVER, FALK AND PORTNOY EMPHASIZE THAT THE BEST SOLUTION TO THE PROBLEM WOULD BE TO USE MECHANICAL-BLADE CUTTING MACHINES THAT DO NOT CREATE FUMES. DESCRIPTORS **## combustion;toxicitythermal decomposition;pvc;human;effects;lung; meat-wrappers asthma; 20898010 %9 a% I i r" f r r*ny PRINTOUT FOR GARY JONES OROER NUMBER 860827-135259-WIZ -001-001 PAGE 10 SET 4 WITH 365 OF 305 ITEMS 20838011 g 100^ REVIEW YEAR 1095 ITEM 23 ACCESSION NUMBER 2051 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT MEAT-WRAPPERS' ASTHMA AUTHOR/AFFILIATION AELONY Y.UNIV OF CALIFORNIA; ORIGIN JAMA,VOL 236 NO.10 PP.1117-1118; DATE ABSTRACT 1976, SEPT 6 SEVERAL OTHER PATIENTS WHO MERE RECEIVING DISABILITY BENEFITS ELSEWHERE FOR "MEAT-WRAPPERS' ASTHMA" WERE FOUND TO HAVE NORMAL PULMONARY FUNCTION AT THE TIME OF REFERRAL TO ME,SUGGESTING REVERSIBILITY OF THE DISEASE PROCESS AFTER CESSATION OF EXPOSURE TO PVC PYROLYSIS PRODUCTS. DESCRIPTORS #***# COMBUSTION;TOXICITY;THERMAL OECOMPOSITION5PVC;HUMAN;EFFECTSj LUNGJMEAT-WRAPPERS ASTHMA; REVIEW YEAR 1995 Ur* ITEM 24 ACCESSION NUMBER 2050 FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT NIOSH RETORT OF HEALTH HAZARDS AND MEAT-WRAPPERS ASTHMA FROM PVC FILMS: REPORTS 72-53,54,55,56, 57,58 AUTHOR/AFFILIATIGN NONE,NONE! ORIGIN NIOSH DATE 1973 ABSTRACT A LIMITED STUDY OF MEAT WRAPPERS WAS CONDUCTED.CLINICAL SYMPTOMATOLOGY COLLECTED FROM TWO GEORGRAPHICALLY SEPARATED GROUPS OF MEAT WRAPPERS IS PRESENTED (18 WRAPPERS FROM SEATTLE, WASHINGTON AND VICIN1TY;17 WRAPPERS FROM LOUISVILLE,KENTUCKY).CLINICAL SYMPTOMATOLOGY COLLECTED FROM OTHER MEDICAL RESEARCHERS IS DISCUSSED.PRE- AND POST-SHIFT PULMONARYFUNCITON TEST RESULTS ARE PRESENTED FOR A GROUP OF 17 BASICALLY HEALTHY MEAT WRAPPERS AND A GROUP OF 20 CONTROLS.NO SIGNIFICANT DIFFERENCE BETWEEN EXPOSED MEAT WRAPPERS AND CONTROLS WAS FOUND AFTER ONE SHIFTS EXPOSURE TO WRAPPING MEAT WITH PVC FILM.NO ENVIRONMENTAL MEASUREMENTS WERE MADE TO CHARACTERIZE EMPLOYEE EXPOSURES DUE TO THE LACK OF SUITABLE METHODS FOR MEASURING BREATHING ZONE CONCENTRATIONS OF DI-Z-ETHYL HEXYL ADIPATE AND OTHER PVC FILM THERMAL DECOMPOSITION PRODUCTS ENCOUNTERED IN RETAIL MEAT WRAPPING. DESCRIPTORS *##* combustion;toxicity;thermal decomposition;pvc;human;effects; lung;meat-wrappers asthma; KWIC INDEX NUMBER 00072 REVIEW YEAR 1995 ITEM 25 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE 2049 GEN REPORT POLYVINYL CHLORIDE MEAT WRAPPING FILM STUDY VANOERVORT R,HEWJ OSHA,FOR FDA; 1970 Orr^ ! r r r" Y inMrr 2 ]38012 PRINTOUT FOR GARY JONES ORDER NUMBER 860627-135ZS9-WIZ >001-001 PAGE 11 SET 4 MITH 365 OF 3S5 ITEMS ABSTRACT DESCRIPTORS REVIEW YEAR A STUDY HAS INITIATED AS A RESULT OF COMPLAINTS ASSOCIATED WITH FUMES PRODUCED BY HOT HIRE CUTTING OF FILM IN MEAT NRAPPING OPERTIONS.THE MEAT HRAPPIN6 MATERIAL STUDIED HAS POLYVINYL CHLORIDE FILM.ATMOSPHERIC SAMPLES COLLECTED IN THE WORKING ENVIRONMENT INDICATED ONLY TRACE AMOUNTS OF HYDROGEN CHLORIDE.AN ANALYSIS OF THE FILM THERMAL DECOMOSITION PRODUCTS HAS CONDUCTED.TRACE AMOUNTS OF SEVERAL COMPOUNDS INCLUDING BENZYL CHLORIDE HERE IDENTIFIED.IT NAS DETERMINED THAT VOLATILE COMPOUNDS FROM FILM DECOMPOSITION HERE NOT PRODUCED IN SUFFICIENT QUANTITY TO EXCEED THRESHOLD LIMIT VALUES. RESULTS INDICATE THAT POLYVINYL CHLORIDE FILM FUMES PRESENT NO APPARENT HEALTH HAZARD TO MEAT WRAPPERS WITH NO PRIOR RESPIRATORY ILLNESS.CONTROL RECOMMENDATIONS ARE GIVEN FOR CASES HHERE WORKERS HAVE A PECULIAR SENSITIVITY. ** COMBUSTION;TOXICITY{THERMAL DECOMPOSITION;PVC;HUMAN{EFFECTS',LUNG, MEAT-WRAPPERS ASTHMA} 1996 ITEM 26 ACCESSION NUMBER 2048 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT RESPIRATORY ILLNESS CAUSEO BY OVERHEATING OF POLYVINYL CHLORIDE AUTHOR/AFFILIATION FRONBERG B>NIOSH>JOHNSON PLSAME{LANDRIGAN PJ,SAMEJ ORIGIN BRITISH J OF INDUSTRIAL MEDICINE,VOL 39 PP.239-243} DATE 19B2 ABSTRACT ON 9 AUGUST 1979. 62 (30.OX) OF 201 WORKERS AND ONE OF 60 MANAGEMENT PERSOtoJEL IN A POLYVINYL CHLORIOE (PVC) FABRICATING PLANT DEVELOPED ACUTE UPPER AND LOWER RESPIRATORY IRRITATION,HEAOACHE, NAUSEA,AND FAINTING.HE ATTRIBUTED THE OUTBREAK TO EXPOSURE TO TOXIC HCL AND CQ AND REJECTED THE HYPOTHESIS OF MASS PSYCHOGENIC ILLNESS. PULMONARY FUNCTION TESTS (PFT) HERE CONDUCTED.HOWEVER, BECAUSE THE GROUP WITH PERSISTENT SYMPTOMS CONTAINED AN EXCESS OF INDIVIDUALS WITH PREVIOUS DESCRIPTORS REVIEW YEAR RESPIRATORY ILLNESS AND BECAUSE NO BASELINE WAS AVAILABLE,THE SIGNIFICANCE OF THE PFT IS UNKNOWN. ******* CQMBUSTIONiTOKlCZTY{THERMAL DEC0MP0SIT10NiPVC{HUMAN{EFFECTS{ LUNG{EPIDEMIOLOGY{ 1995 ITEM 27 ACCESSION NUMBER 2043 FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT OVERVIEW OF FIRE EXPERIENCE IN THE PLASTIC INDUSTRY AUTHOR/AFFILIATION CLARK CA.BFG; ORIGIN BFG OATE 1982 ABSTRACT ALTHOUGH PVC AND CPVC CONSUMPTION HAS INCREASED DRAMATICALLY OVER THE LAST 40 YEARS, THE NUMBER OF FIRE DEATHS HAS REMAINED QUITE STEADY AND HAS EVEN BEEN DECREASING SINCE 1975.THIS DATA DOES NOT SUPPORT THE CONTENTION THAT PLASTICS HAVE MADE FIRE MORE HAZARDOUSAFO HAVE INCREASED FATALITIES. DESCRIPTORS HELD TERMS REVIEW YEAR *# combustion;toxicityithermal decomposition;fires;pvc{cpvc; FATALITIES{CONSUMPTION! 1995 /*' ITEM 28 4f ACCESSION NUMBER 2042 20838012 i Jt .j? ' o vO O nTiiifiir rnn r.r.ny tnnr'i PRINTOUT FOR GARY JONES ORDER NUMBER 660627-135259-MIZ -001-001 PAGE IS SET 4 HITH 365 OF 365 ITEMS FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT PUBLICATION 1. FIRE CASUALTY STUDIES S AUTHOR/AFFILIATION NONE.none; ORIGIN NONE,PP.12-175 DATE ABSTRACT 1977, JANUARY THE AUTHORS REPORT THE RESULTS OF ANALYSES OF 206 FIRE FATALITIES REPRESENTING APPROXIMATELY 50X OF ALL FIRE FATALITIES THAT OCCURRED IN MARYLAND FROM 1971-74.CARBON MONOXIDE POISONING (MANY TIMES EXACERBATED BY ALCOHOL,PRE-EXISTING HEART DISEASE,Altt/OR BURNS) MAS FOUND TO BE THE MAJOR CAUSE OF DEATH.THEY ALSO REPORTED THAT SYNTHETIC MATERIALS MERE A SIGNIFICANT FACTOR IN FIRE DESCRIPTORS HELD TERMS REVIEW YEAR DEATHS IN MARYLAND. , #*#* COMBUSTION;TOXICITYJTHERMAL DECOMPOSITIONJPVCJHYDROGEN CHLORIDE; HYDROGEN CYANIDE;KUI1AN;EFFECTS; fires; FATALITIES;SYNTHETIC PRODUCTS 5NATURAL PRODUCTS5FIRELINE; 1995 ITEM 29 ACCESSION NUMBER 2036 FILE LOCATION GEN OOCUMENT TYPE JOURNAL TITLE OR SUBJECT TOXIC EFFECT OF ALIPHATIC CHLORINATED BYPRODUCTS FROM VINYL CHLORIDE PRODUCTION ON MARINE ANIMALS AUTHOR/AFFILIATION ROSENBERG R,NONE)GRAHN 0,NONE(JOHANSSON L.NONEi' ORIGIN MATER RESEARCH,VOL 9 PP.607-612, DATE 1975 ABSTRACT THE ACUTE TOXIC EFFECTS OF CHLORINATED ALIPHATIC HYDROCARBONS, FORMED AS BY-PRODUCTS FROM ONE SMEOISH AMD ONE NORMEGIAN PLASTIC PRODUCTION FACTORY,MERE EXAMINED BY EXPERIMENTS HITH COD (GADUS MORHUA),SHRIMP (CRANGON) AND A POLYCHAETE (OPHYRYOTROCHA LABRONICA). THE TOXICITY OF 1, 2-OICHLOROETHANE--A DOMINATING COHPOUND OF THE BY-PRODUCTS--AND A DISTILLATE HITH HEAVIER COMPOUNDS MERE ALSO ESTIMATED. THE TOXICITY (48HLC50) RATIO BETHEEN THE CONCENTRATIONS OF A SMEOISH BY-PRODUCT ,A NORMEGIAN BY-PRODUCT, AND DICHLOROETHANE HAS 1:9:34. THE EFFECTS OF 1, 2-DICHLOROETHANE,1,1,2-TRXCHLORDETHANE ANO 1,1,2-TRICHLOROETHENE ON THE REPRODUCTIVITY, AND ON THE SURVIVAL OF ADULTS OF OPHRYOTROCHA MERE STUDIED. THE REPRODUCTIVITY MAS AFFECTED BY THESE COMPONENTS IN FAR LOWER CONCENTRATIONS THAN THOSE HAVING ACUTE TOXIC EFFECTS ON ADULT SPECIMENS. IN ONE EXPERIMENT SERIES OPHRYOTROCHA MAS EXPOSED SUDOENLY TO THE TEST SOLUTIONS AND IN A SECOND SERIES THE FIRST PRESENTATION MAS NAOE BY A SUCCESSIVE INCREASE OF THE CONCENTRATION DURING ONE HOUR. THE ESTIMATED 96-H LC50-VALUES FOR THE TEST MITH SUCCESSIVE INCREASE MERE 1S6-3U TIMES HIGHER THAN THOSE FOUND FOR THE TEST HITH SUDDEN EXPOSURE. IT IS SUGGESTED THAT A PHYSIOLOGICAL SHOCK IN THE START OF BIOASSAY EXPERIMENTS MIGHT HAVE REDUCED THE LC50- VALUES IN MANY PREVIOUS TESTS. OESCRIPTORS *##*## vcm;eoc;effects;aquatic toxicity; i,i,2-trichloroethane; HELD TERMS KMIC INDEX NUMBER i,i,2-trichloroethene;chlorinated hydrocarbons; SMEDISH HATER AM) AIR pollution research lab; 01020PUBL REVIEW YEAR 1990 ITEM 30 ACCESSION NUMBER FILE LOCATION 2034 GEN 20S9S013 BFG52702 I Z< 3SOH PRINTOUT FOR GARY JONES ORDER NUMBER 860827-13S259-WIZ -001-001 PAGE 13 SET 4 WITH 385 OF 385 ITEMS DOCUMENT TYPE JOURNAL TITLE OR SUBJECT THE INFLUENCE OF SOME BYPRODUCTS FROM VINYL CHLORIOE ON ON FEPRODUCTION ON FERTILIZATION, DEVELOPMENT AND LARVAL NO HERRISURVIVAL ON PLAICE,COO AND HERRINS EGGS AUTHOR/AFFILIATION BRAATEN B,NONE?MOLLERUD FE,NONEJSOLEMOAL P,NONEt ORIGIN NONE,PP.81-90; OATE 1972 ABSTRACT THE EFFECT OF BYPRODUCTS FROM NORWEGIAN VINYLCHLORIDE PRODUCTION ON FERTILIZATION,EGG DEVELOPMENT AND LARVAL SURVIVAL WAS TESTED. EGGS AND LARVAE OF PLAXCECOD AND HERRING APPARENTLY SEEMED UNAFFECTED BY CONCENTRATIONS UP TO 10 PPM,BUT CONCENTRATIONS OF 100 AND 50 PPM DELAY AND STOP DEVELOPMENT OF PLAICE EGGS IN AN EARLY STAGE. COO LARVAE SEEMEO TO SURVIVE HIGH CONCENTRATIONS OF THE TOXIC SUBSTANCES FOR FAR LONGER PERIODS THAN DID I ANO II YEAR GROUPS OF SAITHE. DESCRIPTORS ******* VCMJ EFFECTS? AQUATIC TOXICITYt HELO TERMS INSTITUTE OF MARINE RESEARCH (NORWAY)? KMIC INDEX NUMBER Q1016PUBL REVIEW YEAR 1991 ITEM 31 ACCESSION NUMBER FILE LOCATION OOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ******* KWIC INDEX NUMBER REVIEW YEAR 2003 GEN COMPANY CORR COMBUSTION PRODUCTS OF PVC AND THEIR EFFECTS, PARTICULARLY L KCL NONE,NONE? BFG 1972 POLYVINYL CHLORIDE? HYDROGEN CHLORIDE? XWALATION? CARBON MONOXIDE? 00914CORR 1990 ITEM 32 ACCESSION NUMBER 1978 FILE LOCATION GEN DOCUMENT TYPE COMPANY CORR TITLE OR SUBJECT MODIFIERS FOR POLYVINYL CHLORIDE FOOD CONTACT ARTICLES .2597 CFR121.2597 AUTHOR/AFFILIATION FELSKE FG.ROHM AND HAAS? ORIGIN ROHM AND HAAS,TO BFG? OATE 1967, OCTOBER 18 ABSTRACT ACRYLOID K-120N (SERIAL 438587), ACRYLOID KN-228 (SERIAL 633577).EXPERIMENTAL POLYMER 6607-XP, EXPERIMENTAL POLYMER 550-42 (SERIAL 475176) ARE PERMITTED UNDER SECTION CFR121.2597. DESCRIPTORS ******* FDA ACCEPTANCE? PVCt HELD TERMS CFR121.2597? SERIAL 475176? SERIAL 438587? SERIAL 633577? EXPERIMENTAL POLYMER 550-42? EXPERIMENTAL POLYMER 6607-XP? ACRYLOID KM-227? ACRYLOID KM-228? EXPERIMENTAL POLYMER? CFR121.2597? ACRYLOID K-120N? KWIC INDEX NUMBER REVIEW YEAR 00861CORR . 1988 ITEM 33 20833014 r-\ \n o J f mi f*M)Y triMfr 4 PRINTOUT FOR GARY JONES ORDER NUMBER B60B27-135259-WIZ -001-001 PAGE 14 SET 4 WITH 365 OF 365 ITEMS ACCESSION NUMBER 1945 FILE LOCATION GEN DOCUMENT TYPE TOXICITY STUDY TITLE OR SUBJECT TOXICOLOGIC REPORT ON 6E0N 63403 AUTHOR/AFFILIATION NONE,NONE; ORIGIN NONE>FOR BFG5 DATE 1970. MAY 7 ABSTRACT GEON 63403: NO DEATH IP OR IV IN MICEJNO SIGNIFICANT REACTION IN RABBIT INTRACUTANEOUS REACTIVITY TEST; NO SIGNIFICANT TISSUE REACTION IN RABBIT INTRAMUSCULAR IMPLANT STUDY. DESCRIPTORS ******* TOXICITY DATA; IP; PVC5 IV; RABBITS; IMS HELD TERMS GEON 63403; IMPLANT;INTRACUTANEOUS5HUNTINGDON RESEARCH CENTER; KWIC INDEX NUMBER 00793TOXS REVIEW YEAR 1990 ITEM 34 ACCESSION NUMBER 1943 FILE LOCATION GEN DOCUMENT TYPE TOXICITY STUDY TITLE OR SUBJECT TOXICOLOGIC REPORT ON X-1053 PLASTIC INFLATABLE CATHETERS AUTHOR/AFFILIATION NONE,none; ORIGIN NONE DATE 1969 ABSTRACT PVC CATHETERS TOXICITY DATA SHOWED NO SIGNIFICANT TOXICITY OF ELUATES IV OR IP (MICE); INTRACUTANEOUS REACTIVITY TEST DID NOT SHOW ANY REACTIONS INTRAMUSCULAR IMPLANTS REMAINED FREE OF SIGNIFICANT TISSUE REACTIONS. 0E SCRIPTOR S ******* iv; ip; pvc; rabbits; mice; im; HELD TERMS KWIC INDEX NUMBER catheters; implantsjhuntingoon research centerjintracutaneous; 00790TOX3 REVIEW YEAR 1991 ITEM 35 accession number 1939 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT POLYVINYL CHLORIDE PULMONARY DISEASE AUTHOR/AFFILIATION PIMSKER kl,none;fell s,same;kamholz si,same; ORIGIN NONE,VOL 60 NO.6 PP.768; DATE 1961, DECEMBER ABSTRACT THE ARTICLE BY COROASCO ET AL (CHEST,198178:628-34) AND THE ACCOMPANYING COMMENTARY B LILIS (76:626-28) PROVIDE AN EXCELLENT REVIEW OF THE PULMONARY MANIFESTATIONS OF POLYVINYL CHLORIDE(PVC) EXPOSURE. PULMONOLOGISTS MUST BE AWARE OF THE CONSTANTLY EXPANDING NUMBER OF POTENTIALLY DANGEROUS INDUSTRIAL, AND OFTEN UBIQUITOUS, ENVIROW1ENTAL HAZARDS. DESCRIPTORS ******* combustion;toxicity;thermal decomposition;pvc;human;effects;lung; bloc; HELD TERMS hypoxemia;chest;albert einstein college of medicine; REVIEW YEAR 1995 ITEM 36 20S9S015 BFG52704 2(v Rm.r, PRINTOUT FOR 6ART JONES OPOER NUMBER 060027-135259-WIZ >001-001 PAGE IS SET 4 HITH 385 OF 385 ITEMS ACCESSION NUMBER 1930 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT A CRITIQUE OF TWO PAPERS ON "DANGERS Of POLYVINYL CHLORIDe MIRE INSULATION DECOMPOSITION" AUTHOR/AFFILIATION CLEVELAND FP,NONES ORIGIN J OF COMBUSTION TOXICOLOGY.VOL 9 PP.115-120J OATE 1902, AUGUST ABSTRACT IN CONCLUSION* IT IS ALMOST IMPOSSIBLE TO ACCEPT ANY PORTION OF THE PAPERS AS HAVING ANY DOCUMENTED, FACTUAL INFORMATION TO BE USED FOR REFERENCE BY ANY PERSON INTERESTED IN THERMAL DECOMPOSITION AND THE HEALTH EFFECTS OF DECOMPOSITION PRODUCTS. BOTH PAPERS ARE POORLY PRESENTED, 00 NOT REPRESENT A SCIENTIFIC INVESTIGATION. ANO 00 NOT DEMONSTRATE AWARENESS OF THE CONTENT OF THE REFERENCES .ALTHOUGH THESE PAPERS ARE UNLIKELY TO IMPRESS ANY PROFESSIONALS, THE SAD FACT IS THAT SUCH MISINFORMATION CAN RESULT IN UNFOUNDED ALARM IN THE LAY PUBLIC WHO MAY READ THIS. DESCRIPTORS **** combustion{toxicity{thermal decomposition;pvc;fires;humanseffects; REVIEW YEAR i one ITEM 37 ACCESSION NlffER 1928 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT POLYVINYL CHLORIDE WIRE INSULATION DECOMPOSITION^ II.'CONSIDERATION OF LONG TERM HEALTH EFFECTS FROM CHLORINATED HYDROCARBONS AUTHOR/AFFILIATION WALLACE D,NONE; NELSON N,NONE{GATES T,NONES' ORIGIN J OF COMBUSTION TOXICOLOGY,VOL 9 PP.105-112 DATE 1982, MAY ABSTRACT THE AUTHOR CONTENDS THAT HEALTH EFFECTS NOTED IN THE NYC TELEPHONE FIRE AND THE BEVERLY HILLS SUPPER CLUB FIRE ARE DUE TO PVC. THIS IS A VERY POORLY WRITTEN REPORT AND A POORLY COtBUCTEO SURVEY. NUMEROUS REFERENCES PROVIDED 00 NOT SUPPORT OR EVEN RELATE TO THE STATEMENTS MADE. THE AUTHOR OISPLAYS A COMPLETE LACK OF UNDERSTANDING OF TOXICOLOGY OR EPIDEMIOLOGY. THE CRITIQUE OF THIS PAPER BY DR. CLEVELAND 11982> DISCUSSES THE MANY FLAWS. WALLACE STUDY OF THE NYC TELEPHONE FIRE HAS ALSO BEEN CRITICIZEO BY NIOSH(19BO). DESCRIPTORS **** COMBUSTION{TOXICITY{THERMAL DECOMPOSITION {FIRES {PVCJHUMAN; EFFECTS', REVIEW YEAR 1995 / ITEM 38 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE ABSTRACT 1927 GEN JOURNAL DANGERS OF POLYVINYL CHLORIDE HIRE INSULATION DECOMPOSITION. 1.L0N6 TERM HEALTH IMPAIRMENTS: STUOIES OF FIREFIGHTERS OF THE 1975 NEW YORK TELEPHONE FIRE AND OF SURVIVORS OF THE 1977 BEVERLY HILLS SUPPER CLUB FIRE WALLACE ON,NONE; J OF COMBUSTION TOXICOLOGY,VOL 8 PP.205! 1981, NOVEMBER THE AUTHOR CONTENDS THAT HEALTH EFFECTS NOTED IN THE NYC TELEPHONE FIRE AND THE BEVERLY HILLS SUPPER CLUB FIRE ARE OUE TO PVC. THIS IS A VERY POORLY WRITTEN REPORT AND A POORLY CONDUCTED SURVEY. NUMEROUS REFERENCES PROVIOED DO NOT SUPPORT OR EVEN RELATE TO THE STATEMENTS MAOE. THE AUTHOR OISPLAYS A COMPLETEfcACK OF UWERSTANDING OF TOXICOLOGY OR EPIDEMIOLOGY. THE CRITIQUE OF 20898016 v t "iiMir fi. puny irutr'? # * PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-UIZ <001-001 PAGE 16 SET 4 WITH 385 OF 385 ITEMS DESCRIPTORS REVIEW YEAR THIS PAPERY BY DR. CLEVELAND (1982) DISCUSSES THE MANY PLANS. WALLACE STIIOY OF THE NYC TELEPHONE FIRE HAS ALSO BEEN CRITICIZED BY NIOSH (1980). ***mk COMBUSTIONJTOXICITYSTHERMAL decompositidnjfiresspvcjhumanjeffects; 1995 ITEM 39 ACCESSION NUMBER 1919 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT POLYVINYL CHLORIDE TOXICITY IN FIRES:HYDROGEN CHLORIDE TOXICITY IN FIRE FIGHTERS AUTHOR/AFFILIATION DYER RF.NONE5ESCH VH.NONEJ ORIGIN JAMA.VOL 235 NO.4 PP.393-397J DATE 1976 ABSTRACT THE AUTHORS CONTEND THAT PVC/HCL HAS BEEN IMPLICATED AS CAUSING A SERIOUS PROBLEM IN FIRE FIGHTING AND REPORT THAT 175 FIREFIGHTERS EXPERIENCED SYMPTOMS RESULTING FROM INHALIN6 PVC ' DECOMPOSITION PRODUCTS. HOWEVER. THE FACTS ARE THAT THERE IS VERY LITTLE BASIS PRESENTED WHICH WOULD SUPPORT SUCH BOLD CONCLUSIONS. THE AUTHORS FAIL TO OOCUMENT THAT PVC MAS PRESENT AS OPPOSED TO SOME OTHER PLASTIC. HCL IS PREENTED AS UNIQUE TO PVC.NO CONSIDERATION IS GIVEN TO THE FACT THAT HCL CAN BE PRODUCED BY OTHER POLYMERS OR FLAME RETARDANTS. FURTHERMORE.THE AUTHORS FAIL TO POINT OUT OR TO RECOGNIZE THAT THE SYMPTOMS REPORTED ARE NON-SPECIFIC AND CAN BE CAUSED BY THE COMBUSTION OF COMMON MATERIALS SUCH AS WOOD (ZIKRIA ET AL, 1972 AND COPE A RHINELANDER. 1943).ANOTHER PROBLEM WITti THIS REPORT IS THAT THE AUTHORS MIXUP THE EFFECTS OF HCL AND CO. THEY SUGGEST THAT HCL EFFECTS CORONARY CIRCULATION WHERE.IN FACT. IT IS WELL DOCUMENTED THAT CO PLACES A STRESS ON CORONARY SUFFICIENCY AND CAN HAVE A DEMONSTRABLE EFFECT ON PEOPLE WITH CORONARY HEART DISEASE. THE RECOMMENDATION OF USING A SELF-CONTAINED BREATHING APPARATUS IS A GOOD ONE.BUT NOT JUST BECAUSE OF PVC.IT IS NOW RECOGNIZED THAT THIS SHOULO BE FOLLOWED FOR ALL FIRES. DESCRIPTORS *##** COMBUSTION{TOXICITY.PVCJHCL.HUMAN.EFFECTS5 FIRES.ACUTE.LUNG. HEART. KWIC INDEX NUMBER 03998 REVIEW YEAR 1995 ITEM 40 ACCESSION NUMBER 1918 FILE LOCATION GEM OOCUMENT TYPE PUBLICATION TITLE OR SUBJECT ACUTE INHALATION-INTOXICATION BY COMBUSTION OF POLYVINYLCHLORIDE AUTHOR/AFFILIATION ORIGIN COLARDYN F,HONE5VAN DER STRAETEN M.SAME5LAMONT H.SAME. VAN PETEGHEM TH.SAME! INTERNATIONAL ARCHIVES OF OCCUPATIONAL A ENVIRONMENTAL HEALTH. VOL 38 PP.121-127; DATE 1976 ABSTRACT THE PULMONARY EFFECTS OF AN ACUTE INTOXICATION BY INHALATION OF GASES PRODUCED BY COMBUSTION OF POLYVINYLCHLORIDE ARE STUDIED IN 20 PERSONS.INITIALLY EACH SUBJECT SHOWED A SYNDROME OF ACUTE OBSTRUCTIVE LUNG DISEASE. AFTER A FOLLOW-UP PERIOO OF 3 MONTHS RESIOUAL INJURIES SEEMED TO PERSIST. DESCRIPTORS **** combustion;tqxicitythermal decomposition;fires;hwian;effects; pvc;lung;acute; HELD TERMS ELECTRICAL WIRE! KWIC INDEX NUMBER 04245 REVIEW YEAR 1995 20898017 BFG52706 I PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-WIZ -001-001 PAGE 17 SET 4 HITH 365 OF 365 ITEMS ITEM 41 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS *** HELD TERMS REVIEW TEAR 1867 GEN dp PUBLICATION THROMBOGENESIS ASSOCIATED WITH SWAN-GANZ CATHETERS HOAR PFNONE;STONE JG.SAMEJHICKS AEtSAMES EDIE RNSANEtSCHOLES JVSAME; NONE>VOL 46 NO.6 PP.445-447; 1976, JUNE THROMBOCYTOPENIA,PVCJBLOOD(ARTERY, CATHETERS;SWAN-GANZ CATHETER(PLATELETS{THROMBOGENESIS,COLUMBIA UNIVJ 1990 ITEM 42 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ******* HELD TERMS REVIEW YEAR 1666 GEN JOURNAL BALLOON FLOTATION CATHETERS: THEIR USE IN HEMODYNAMIC MONITORING IN CLINICAL PRACTICE SWAN hjc.none; JAMA,VOL 233 NO.8 PP.865-667; 1975, AUGUST 25 SWAN-GANZ CATHETERS USE AND HEMODYNAMIC MONITORING IN CLINICAL PRACTICE DISCUSSION. THROMBOCYTOPENIA 5 BLOOD;PVC;ARTERYi THROMBOGENSIS{CATHETER;SWAN-GANZ CATHETER{PLATELETS; 1990 '* ITEM 43 ACCESSION NUMBER 1665 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT THROMBOCYTOPENIA AND ALTERED PLATELET KINETICS ASSOCIATED HITH PROLONGED PULMONARY-ARTERY CATHETERIZATION IN THE DOG AUTHOR/AF F1 LIATION RICHMAN KA.NONEJKIM YL,NONE{MARSHALL BE,NONE; ORIGIN NONE,VOL 53 NO.2 PP.101-105; DATE 1980, AUGUST ABSTRACT THE AUTHORS STUDIED PLATELET KINETICS IN HEALTHY DOGS SUBJECTED TO PULMONARY-ARTERY (SWAN-GANZ) CATHETERIZATION. SIGNIFICANT THROMBOCYTOPENIA WITH DECREASED PLATELET SURVIVAL IS ASSOCIATED WITH THE USE OF SWAN-GANZ CATHETERS IN OOGS. D ESCRIPTORS ******* THROMBOCYTOPENIA;ARTERY{BLOOD}PVC{ HELD TERMS REVIEW YEAR SWAN-GANZ CATHETER;CATHETEP;PLATELETS;THR0MB0GENSZS;UNIV OF PENNSYLVANIA HOSPITAL;UNIV OF PENMSYLVANIA;NATIONAL UNIV (SEOUL); 1990 .J ITEM 44 ACCESSION NUMBER FILE LOCATION 1864 GEN 20898018 r-Mcrr-nT n,n r*PY TnNP? r-. .,v0^n-I a PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-WIZ '001-001 PAGE 18 SET 4 WITH 385 OF 385 ITEMS s DOCUMENT TYPE JOURNAL r TITLE OR SUBJECT INDWELLING PULMONARY ARTERY CATHETERS* THEIR RELATIONSHIP TO ASPETIC THROMBOTIC ENDOCARDIAL VEGETATIONS AUTHOR/AFFILIATION THORSTEINSSON 5B,NONEMUSHER OM,NONE;FAGAN T,NONE 5 ORIGIN JAMA>VOL 233 NO.8 PP.893-894; DATE 1975* AUGUST 25 ABSTRACT TO ASSESS THE INCIDENCE OF ASEPTIC THROMBOTIC ENDOCARDIAL VEGETATIONS (TEV) AFTER PULMONARY ARTERY CATHETERIZATION NITH SWAN-GANZ CATHETERS NE REVIEWED ALL AUTOPSY REPORTS FOR A TWO- YEAR PERIOD IN OUR HOSPITAL. THE INCIDENCE OF TEV IS SIGNIFICANTLY 6REATER IN PATIENTS WITH SWAN-GANZ CATHETERS THAN IN OTHER PATIENTS. DESCRIPTORS ***##* THROMBOCYTOPENIA}ARTERY5BLOOD5PVC5 HELD TERMS thrombogensis;catheter;swan-ganz catheter;platelets; REVIEM YEAR 1990 ITEM 45 ACCESSION NUMBER 1863 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT ASEPTIC THROMBOTIC ENDOCARDIAL VEGETATIONS AUTHOR/AFFILIATION GREENE JF,NONE 5CUMMINGS KCNONE> ORIGIN JAMA,VOL 225 NO.12 PP.1525-1526; DATE 1973, SEPTEMBER 17 ABSTRACT ENOOCARDIAL LESIONS ASSOCIATED WITH INDWELLING PULMONARY ARTERY CATHETERS POSE POTENTIAL RISKS OF EMBOLIZATION AND INFECTION. DESCRIPTORS *** THROMBOCYTOPENIA;ARTERY,BLOOD;PVC J HELD TERMS REVIEW YEAR thrombogensis;catheter;swan-ganz catheter;putelets;letterman army medical center; 1990 ITEM 46 ACCESSION NUMBER 1862 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT SEPTIC ENDOCARDITIS AND INDWELLING PULMONARY ARTERY CATHETERS AUTHOR/AFFILIATION GREENE JF,N0NE;FITZWATER JE.SAMEJCLEMMER TP,SAME; ORIGIN JAMA,VOL 233 NO. 8 PP.891-8925 OATE 1975, AUGUST 25 ABSTRACT NO ASSOCIATION BETWEEN THE USE OF INDWELLING CATHETERS IN THE RIGHT SIDE OF THE HEART AND ENDOCARDITIS IN THE LEFT, ALTHOUGH THERE IS A RISK OF THROMBOTIC ENDOCARDIAL VEGETATION FORMATION DESCRIPTORS HELD TERMS REVIEW YEAR IN THE RIGHT SIDE OF THE HEART,WITH POSSIBLE INFECTION OR EMBOLIZATION. #**** THROMBOCYTOPENIA J ARTERYiB LOOD}PVC} THROMBOGENSIS CATHETER;SWAN-GANZ CATHETER 5 PLATE LET; LETTERMAN ARMY MEDICAL CENTER; 1990 ITEM 47 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE 1861 GEN PUBLICATION 20898019 o* \n o I BFG52709 PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-WIZ >001-001 PAGE 19 SET 9 WITH 385 OF 385 ITEMS TITLE M SUBJECT AUTH OR/AF FILIATION THROMBOCYTOPENIA ASSOCIATED WITH SUAN-0ANZ CATHETERIZATION IN PATIENTS KIM YL.NONESRICHHAN KA,NONEMAR5HALWiE,NONEJ <; . ORIGIN DATE ABSTRACT NONE.VOL 53 NO.3 PP.261-2621 jT 1980. SEPTEMBER jr IN THE PRESNT STUDY, HE EXAMINED THE EFFECTS OF SWAN-GANZ CATHETERS UPON PUTELET COUNTS IN ADULT PATIENTS UNDERGOING CQRONARY-ARTERY BYPASS GRAFT OPERATIONS. DESCRIPTORS ******* pvc;blood;thrombocytopenxa? HELD TERMS thrombogensis;catheter;snan-ganz catheter ; plate lets >univ of Pennsylvania; national univ cseouus UNIV OF PENNSYLVANIA HOSPITAL! ANESTHESIOLOGY! REVIEW YEAR 1990 ITEM 46 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ******* HELD TERMS REVIEH YEAR 1858 GEN TOXICITY DATA EVALUATION OF THE SKIN IRRITATING AND SENSITIZING PROPENSITIES OF GEON 137 IN HUMANS NONE.none; y HONE,REPORT NO. PI-3870; 1985, JULY 16 HUMAN PATCH TEST USING A PANEL OF 50 SUBJECTS;NOT A SKIN IRRITANT OR SENSITIZER. pvc;skin irritation;sensitization;human patch test; human;effects;acrylic acid; ACRYLIC ACID COPOLYMER; GEON 137; PROOUCT INVESTIGATIONS INC; 1995 * ITEM 49 ACCESSION NUMBER 1857 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT NONBACTERXAL THROMBOTIC ENDOCARDITIS ASSOCIATED WITH SEVERE PREECLAMPSIA AND PULMONARY ARTERY CATHETERIZATION CA CASE REPORT) AUTHOR/AFFILIATION ORIGIN CHESTNUT DH,NONE;LUMB PD,SAMEjJELOVSEK F.SAMEJKILLAM AP, SAME; NONE,VOL 30 NO.6 PP.997-500;/ DATE 1985, JUNE ABSTRACT AUTOPSY REVELAED MULTIPLE PULMONARY THROMBOEMBOLX AND TRIVALVULAR NONBACTERIAL THROMBOTIC ENDOCARDITIS. * DESCRIPTORS ******* pvc;blood;thrombocytopenia; HELD TERMS THROMBOGENESIS;SWAN-GANZ CATHETER; DUKE UNIVJJ OF REPRODUCTIVE MEDICINE;CATHETER; REVIEW YEAR 1990 ITEM 50 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN 1641 GEN PUBLICATION EVALUATION OF THE PULMONARY TOXICITY OF PLASTICIZED POLYVINYL CHLORIDE THERMAL DECOMPOSITION PRODUCTS IN GUINEA PIGS BY REPEATED C02 CHALLENGES WONG KL.UNIV OF PITTSBURGH5STOCK MF,SAMEALARIE YC.SAME; TOX AND APPLIED.VOL 70 PP.236-298, 20898020 I ( ........ * PRINTOUT FOR GARY JONES OROER NUMBER 660627-135259-UIZ -001-001 PAGE 20 SET 4 WITH 365 OP 365 ITEMS DATE ABSTRACT DESCRIPTORS REVIEW YEAR 1963 HALE GUINEA PIGS HERE EXPOSED TO THERMAL DECOMPOSITION PRODUCTS OF PLASTICIZED POLYVINYL CHLORIDE (PVC-A) AT DIFFERENT CONCENTRATIONS UP TO LEVELS INDUCING ACUTE LETHALITY. SEVERAL GROUPS EXPOSED AT SU8LETHAL LEVELS MERE THEN EVALUATED FOR PULMONARY PERFORMANCE FOR A PERIOD OF 57 DAYS FOLLOWING EXPOSURE. PULMONARY PERFORMANCE MAS EVALUATEO BY CHALLENGING EACH ANIMAL WITH A MIXTURE CONTAINING 10X CO2.20X 02, AND 70* N2. IN CONTROL ANIMALS, THIS MIXTURE INDUCED AN INCREASE IN BOTH TIOAL VOLUME AND RESPIRATORY FREQUENCY. THIS HYPERVENTILATORY RESPONSE MAS GREATLY OEPRESSEO DURING THE FIRST 3 DAYS FOLLOWING EXPOSURE AND GRADUALLY RETURNED TO NORMAL DURING THE FOLLOWING WEEKS WITH THE EXCEPTION OF THE HI6HEST EXPOSURE GROUP WHICH STILL SHOWEO A DIMINISHED RESPONSE 57 PAYS AFTER EXPOSURE. THE PULMONARY TOXICITY INDUCED BY THERMAL DECOMPOSITION PRODUCTS OF PVC^A IS PROBABLY RELATED TO THE VERY LARGE AMOUNT OF HCL RELEASED DURING THERMAL DECOMPOSITION* THE C02 RESPONSE TEST, A NONINTRUS1VE AND NONINVASIVE METHOD TO EVALUATE PULMONARY PERFORMANCE IN GUINEA PIGS, IS EASILY PERFORMED AND APPEARS TO BE A VERY PROMISING TYPE OF PULMONARY FUNCTION TEST FOR TOXICOLOGICAL EVALUATIONS. ******* PVCJCARBON MONOXIDE(GUINEA PIGS(RESPIRATORY EFFECTS;LUNGS? PULMONARY FUNCTION{THERMAL DECOMPOSITIONJCOMBUSTION(TOXICITY( 1990 ITEM 51 ACCESSION NUMBER 1640 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT EVALUATION OF THE PULMONARY EFFECTS OF WOOD SMOKE IN GUINEA PIGS BY REPEATED C02 CHALLENGES AUTHOR/AFFILIATION WONG KLtUNIV OF PITTSBURGH{STOCK MFSAME;MALEK DE.SAME) ALARIE Y,SAME{ ORIGIN TOX AND APPLIED,VOL 75 PP.69-60*, DATE 1984 ABSTRACT MALE,ENGLISH SMOOTH HAIRED GUINEA PIGS WERE EXPOSED TO THERMAL DECOMPOSITION PRODUCTS,I.E., SMOKE,GENERATED BY HEATING DOUGLAS FIR IN AN OPEN SYSTEM. VARIOUS AMOUNTS OF DOUGLAS FIR WERE PLACED IN A FURNANCE.AT ROOM TEMPERATURE, ANO HEATED AT A RATE OF 11 DEGREES C/MIN UNTIL COMPLETELY DECOMPOSED. MAJOR DECOMPOSITION OCCURREO BETWEEN 160 AND 490 DEGREES C, AND THE ANIMALS WERE EXPOSEO DURING THIS TIME FOR A PERIOD OF 30 MIN. IMMEDIATELY BEFORE EXPOSURE AND AT VARIOUS TIMES AFTER EXPOSURE,EACH ANIMALS WAS EVALUATEO BY WHOLE-BODY PLETHYSMOMOGRAPHY TO MEASURE TIDAL VOLUME AND RESPIRATORY FREQUENCY DURING AIR BREATHING AS WELL AS OURING CHALLENGE WITH 10Z C02. EXPOSURE TO SMOKE FROM DOUGLAS FIR RESULTED IN A DIMINISHED VENTILATORY RESPONSE TO 10Z CQ2. COMPARING THE EFFECT OF WOOD SMOKE WAS FOUND TO BE 10 TIMES LESS POTENT THAN SMOKE FROM POLYVINYLCHLORIDE AND ANIMALS RECOVERED MUCH MORE RAPIDLY THAN WITH SMOKE FROM POLYVINYLCHLORIDE. DESCRIPTORS ******* ' WOOD5PVC5GUINEA PIGS;LUNGS{RESPIRATORY EFFECTS(PULMONARY FUNCTION; COMBUSTION{TOXICITY{THERMAL DECOMPOSITIOmCARBON MONOXIDE? REVIEW YEAR 1990 ITEM 52 ACCESSION NUMBER FILE LOCATION OOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE 1805 GEN PUBLICATION VINYL CHLORIDE-ASSOCIATED DISEASE LELBACH WK,NONE{MARSTELLER HJ.NONE? NONE,VOL 47 PP.1-1105 1981 208380Z1 \ tt r-it1 '*'pv ''iir1' PRINTOUT FOR GARY JONES ORDER NUMBER 660827-135259-WIZ -001-001 PAGE 21 SET 4 WITH 365 OF 385 ITEMS ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR THIS IS AN EXTENSIVE REVIEU COVERING PRODUCTION,TOXICOLOGY, CHEMICAL AGENTS,PATHOLOGY CONSIDERATIONS,NON-MALIGNANT DISEASE,.ANGIOSARCOMA, AND MANY OTHER ASPECTS* ******* pvc;vcm;acute;chronic;carcinogenicity;angiosarcoma;acroosteolysis; mutagenicity ^metabolism; pharmacokinetics; THROMBOCYTOPENIAJUNIV OF BONN (flfRMANY)|ADVANCES IN INTERNAL HEOICINE AND PEDIATRICS; DtlUNOLOGY; 1991 ^TEM 53 ' ACCESSION NUMBER leoi FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT MALIGNANT TUMORS OF THE LIVER AND LUNGS IN AN AREA WITH A PVC INDUSTRY AUTHOR/AFFILIATION saric m,none;kulcar z,none;zorica m,none;gelic inone; ORIGIN ENVIRONMENTAL HEALTH PERSPECTIVES,VOL 17 PP.169-192; DATE 1976, OCTOBER ABSTRACT THE INCIDENCE OF MALIGNANT TUMORS OF THE LUNG AND BRONCHUS AND OF CYTOLOGICALLY CONFIRMED PRIMARY MALIGNANT TUMOR OF THE LIVER WAS ANALYZED FOR A 4-YR PERIOD IN A CITY WITH SEVERAL FACTORIES, INCLUDING A PVC INOUSTRY. PRIOR TO THE STUDY TWO CASES OF ANGIOSARCOMA OF THE LIVER WERE DIAGNOSED IN WORKERS EMPLOYED IN PVC PRODUCTION. THE STUDY DOES NOT INDICATE THAT THE OCCURRENCE OF MALIGNANT TUMORS OTHER THAN ANGIOSARCOMA IS ASSOCIATED WITH EXPOSURE TO VINYL CHLORIDE. DESCRIPTORS ******* vcm;pvc;liver;effects;lung;angiosarcoma;human;epidemiology; HELD TERMS INSTITUTE FOR MEDICAL RESEARCH & OCCUPATIONAL HEALTH (YUGOSLAVIA); REVIEU YEAR 1992 ITEM 54 ACCESSION NUMBER 1600 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT AUTHOR/AFFILIATION TUMORS IN PATIENTS WITH ANGIOSARCOMA OF THE LIVER VIANNA NJ,NONES f ORIGIN NONE,VOL 95 NO.2 PP.165-166; DATE 1961, AUGUST ABSTRACT MOST PATIENTS WITH WELL-DOCUMENTED ANGIOSARCOMA OF THE LIVER HAVE NOT DOCUMENTED EXPOSURE TO ANY OF THESE THREE CHEMICALS (l),SOME CONSIDERATION SHOULD ALSO BE GIVEN TO THE POSSIBILITY THAT OTHER AGENTS STRUCTURALLY SIMILAR TO VINYL CHLORIDE (SUCH AS CHLOROPRENE,TRICHLOROETHYLENE) MIGHT PLAY A ROLE IN THE CAUSE OF THIS AND POSSIBLY OTHER MALIGNANT DISORDERS. descriptors ******* vcm;angiosarcoma;thorotrast;human;effects; KELO TERMS ARSENICALS;ANNALS OF INTERNAL MEDICINES REVIEU YEAR 1992 ITEM 55 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 1799 GEN JOURNAL POWER CONSIDERATIONS IN EPIDEMIOLOGIC STUDIES OF VINYL CHLORIDE WORKERS BEAUMONT JJ,NIOSH;BRESLOM HE,NONE; 20898022 I i1 nm|rMit r^'> r^pr iniirs PRINTOUT FOR WRY JONES ORDER NUMBER 860627-135259-UIZ -001-001 PAGE 22 SET 4 WITH 385 OF 385 ITEMS ORIGIN DATE ABSTRACT DESCRIPTORS HELO TERMS REVIEW YEAR AMERICAN J OF EPIDEMI0L8GYVOL 114 NO.3 PP.725-734; 1981 NINE RETROSPECTIVE MORTALITY STUDIES OF WORKERS EXPOSED TO VINYL CHLORIDE MERE REVIEWED TO DETERMINE WHETHER DIFFERENCES IN THEIR HYPOTHESIS TESTING RESULTS MI6HT BE DUE TO DIFFERENCES IN STATISTICAL POWER.'WHERE POSSIBLE, THE POWER OF EACH STUDY HAS CALCULATED FOR CANCER OF THE LUNG* BRAIN AND LIVER. WHEN POWER WAS TAKEN INTO CONSIDERATION* THE RESULTS FOR LIVER AND BRAIN CANCER WERE FOUND TO BE CONSISTENT WITH AN ETIOLOGIC ROLE FOR VINYL CHLORIDE. FOR LUNG CANCER, THE DATA WERE NOT CONSISTENT WITH AN ETIOLOGIC ROLE, IN THAT TWO STUDIES WITH VERY HIGH POWER YIELDED NEGATIVE RESULTS. ******* vcm;lung;cancer;human;effects;epidemiology; STATISTICAL POWER; UNIV OF WASHINGTON; 1992 ITEM 56 ACCESSION NUMBER FILE LOCATION OOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ******* HELO TERMS REVIEW YEAR 1797 GEN PUBLICATION PULMONARY CHANGES AMONG VINYL CHLORIDE POLYMERIZATION WORKERS lilis r,none;anderson h,none;miller a,none;selikoff ij.none; NONE,VOL 69 NO.2 PP.299-303S 1976* FEBRUARY CHEST X-RAY ABNORMALITIES IN VCM/PVC WORKERS IS PRESENTED. PVC;LUNG,EFFECTS{HUMAN;PULMONARY FUNCTIQNiEPIOEMIOLOGY;PVC DUST; chest; 1992 ITEM 57 ACCESSION NUMBER 1796 FILE LOCATION GEN DOCUMENT TYPE BIBLIOGRAPHY TITLE OR SUBJECT THE PHYSIOLOGICAL EFFECTS OF VINYL CHLORIOE AND POLYVINYL CHLORIDE (USERS MANUAL*VOL 1 AND VOL ID AUTHOR/AFFILIATION NONE,NONE; ORIGIN NONE,DEVELOPED OATABASE SYSTEM CALLED BOYO DOCUMENT SYSTEM (BDS)* DATE 1981 ABSTRACT THE FIELD OF OCCUPATIONAL SAFETY AND HEALTH HAS UNDERGONE AN INFORMATION EXPLOSION OVER THE LAST SEVERAL YEARS. THE PVC SAFETY GROUP OF THE SOCIETY OF THE PLASTICS INDUSTRY, INC. (SPIJ HAS ASSEMBLED THE LITERATURE ON RELEVANT RESEARCH FINDINGS APPLICABLE TO THE PHYSIOLOGICAL EFFECTS OF VINYL CHLORIDE (VC) ANO POLYVINYL CHLORIDE (PVC). THIS INFORMATION IS EASILY ACCESSIBLE AND CAN BE CONVENIENTLY SEARCHED. ANY INTERESTED RESEARCHER, ADMINISTRATOR OR LEGAL REPRESENTATIVE MAY REQUEST A SEARCH OF THIS OATABASE. THE INFORMATION OBTAINE0 IN THIS DATABASE WILL BE SUPPORTIVE OF RESPONSES TO GOVERNMENT INQUIRY OR ACTIONS,LITIGATION,AND COMPARISON OF SCIENTIFIC RESULTS. DESCRIPTORS ******* PVCfVCMJTOXICITY DATA* ' HELO TERMS DANIEL P. BOYO li CO; REVIEW YEAR 1992 20838023 BFG52712 PRINTOUT FOR GARY JONES ORDER NUMBER 660827-135259-WIZ -001-001 PAGE 23 SET 4 WITH 385 OF 385 ITEMS ACCESSION NUMBER 1795 | FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT REPORT | EVALUATION OF MORTALITY IN BFGOODRICH WORKERS' A FOLLOW-BACK STUDY OF MEDICAL RECORDS AND DEATH CERTIFICATES (FINAL REPORT)j AUTHOR/AF FILIATION ORIGIN NONE,HONE; NONE,FOR BFGJ DATE ABSTRACT 1974, MAY 17 THIS REPORT (BFGR) SUMMARIZES THE RESPONSE OF TABERSHAW/COOPER ASSOCIATES (TCA) TO A REQUEST FROM B.F. GOODRICH COMPANY (BFG) TO TO EVALUATE THE POSSIBLE ROLE OF VINYL CHLORIDE AS A CAUSATIVE AGENT FOR ANGIOSARCOMA OF THE LIVER IN THEIR MORKERS. MUCH OF THE ACTIVITY CENTERED UPON THE LOUISVILLE,KENTUCKY PLANT WHERE CASES OF ANGIOSARCOMA HAO BEEN IDENTIFIED PREVIOUSLY. AN INTERIM REPORT HAS SUBMITTED BY TCA TO BFG ON HARCH 20, 1974. IT SUMMARIZED MEDICAL AM) INDUSTRIAL HYGIENE RECOMMENDATIONS AND PROGRESS IN EPIDEMIOLOGIC STUDIES. DESCRIPTORS ******* VCM;E PIDEMIOLOGY5HUMAN}EFFECTS} HELD TERMS REVIEW YEAR TABERSHAW/COOPER ASSOCIATES, 1992 ITEM 59 ACCESSION NUMBER 1794 FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT MEDICAL RECORDS AND XIOUSTRIAL HYGIENE STUDIES FOR BFG AUTHOR/AFFILIATION NONE,NONE; ORIGIN NONE,PROGRESS REPORT FOR BFG; DATE 1974, MARCH 20 ABSTRACT THIS REPORT DETAILS THE STATUS AS OF MARCH, 1974, OF CONSULTATIVE ACTIVITIES PROVIDED BY TABERSHAW/COOPER ASSOCIATES,INC. TO BFGOODRICH COMPANY WITH RESPECT TO THE MORTALITY AND MORBIDITY ASCRIBED TO THE HANDLING OF VINYL CHLORIOE, ESPECIALLY IN THE BFGOODRICH LOUISVILLE PLANT. RECOMMENDATIONS AND PROPOSALS ARE ADDRESSED. DESCRIPTORS ******* vcm;epidemiology;human;effects; HELD TERMS TABERSHAW/COOPER ASSOCIATES) REVIEW YEAR 1992 ITEM 60 ACCESSION NUMBER 1793 FILE LOCATION GEN DOCUMENT TYPE PROCEEDINGS TITLE OR SUBJECT BIRTH DEFECTS AM) VINYL CHLORIDE AU1HOR/AFFILIATION EOMONOS.CDC; ORIGIN NIOSH,CONFERENCE ON WOMEN AND THE WORKPLACE (WASHINGTON); DATE 1976, JUNE 17-19 ABSTRACT STATISTICAL COMPARISONS ON DISTANCES VARYING FROM ONE MILE TO 10 MILES OF PARENTAL RESIDENCE TO THE PLANT INDICATED THAT THERE NAS NO DIFFERENCE BETWEEN THE CASES AM) CONTROL. DESCRIPTORS ******* VCM;BIRTH DEFECTSJHUMANJEFFECTS{EPIDEMIOLOGY; REVIEW YEAR 1992 SSU83S % I An v im tr <*. O. - PRINTOUT FOR GARY JONES ORDER NUMBER 660627-135259-UIZ -001-001 PAGE 24 SET 4 WITH 305 OF 305 ITEMS 20838025 ITEM 61 ACCESSION NUMBER 1792 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT VINYL CHLORIDE AND CONGENITAL MALFORMATION AUTHOR/AFFILIATION NONE*none; ORIGIN CDC DATE ABSTRACT 1976 IN MARCH 1975, THE OHIO DEPARTMENT OF HEALTH REP0PTE0 AN INCREASED RATE OF CENTRAL NERVOUS SYSTEM (CNS) MALFORMATIONS IN 3 OHIO COMMUNITIES WHERE POLYVINYL CHLORIDE (PVC) POLYMERIZATION PLANTS ARE LOCATED (1). THE MALFORMATION RATES WERE DERIVEO FROM BIRTH CERTIFICATE DATA FOR 1970-1973 AND WERE COMPAREED WITH SIMILAR DATA FOR THE ENTIRE STATE OF OHIO. THE INCREASE HAS NOT UNIFORM IN THE 3 COMMUNITIES AND APPEARED MOST PROMINENT IN PAINESVILLE. DESCRIPTORS *#** vch;pvc;birth defects;human;effects;epidemiologt; REVIEW YEAR 1992 ITEM 62 ACCESSION NUMBER 1765 FILE LOCATION GEN DOCUMENT TYPE RESEARCH LAB REPORT TITLE OR SUBJECT FURTHER DEVELOPMENT OF A TEST METHOD FOR THE ASSESSMENT OF THE ACUTE INHALATION TOXICITY OF COMBUSTION PRODUCTS AUTHOR/AFFILIATION LEVIN BC.NONEiFOHELL AJ>NONplBlRKY MM,NONEJPAABO M>NONE STOLTE AiNDNEiMALEK O.UNIV OF PITTSBURGH; ORIGIN NONE,REPORT N8SIR 82-2532; DATE 1962* JUNE ABSTRACT THIS REPORT DESCRIBES THE DEVELOPMENT OF A TEST METHOD FOR THE ASSESSMENT OF ACUTE INHALATION TOXICITY OF COMBUSTION PRODUCTS OF MATERIALS. THE PROCEDURE IS PRIMARILY INTENDED FOR RESEARCH AND SCREENING PURPOSES. LIMITATIONS OF THE TEST METHOD ARE IDENTIFIED AND FUTURE WORK TO ADDRESS THEM IS PROPOSED. THE TOXICITY OF PVC HAS CLOSE TO THAT OF WOOD AND CLEARLY WITHIN THE ONE ORDER DESCRIPTORS HELD TERMS OF MAGNITUDE CRITERIA FOR DETERMINING WHETHER MATERIALS ARE SIGNIFICANTLY DIFFERENT. *##*#* combustion;toxicity;thermal decomposition;pvc;rats;effects;acute; SYNTHETIC PRODUCTS .NATURAL PRODUCTS',SMALL SCALE TESTS.NBSJ REVIEW YEAR 1995 ITEM 63 ACCESSION NUMBER FILE LOCATION OOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 1781 GEN JOURNAL AN EVALUATION OF SMOKE TOXICITY AND TOXIC HAZARD OF ELECTRICAL NONMETALLIC TUBING COMBUSTION PRODUCTS PACKHAM SC.NONEJCRAWFORO KBi^ONE; NONE,VOL 2 PP.,37-59; 1984, JAN-FEB SMALL-SCALE SMOKE TOXICITY TESTS HERE PERFORMED ON POLYVINYL- CHLORIDE-BASED ELECTRICAL NONMETALLIC TUBING (PVC/ENT) USING THE NATIONAL BUREAU OF STANDARDS (NBS) PROTOCOL FOR NONFLAMING vn o I PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-WIZ >001-001 PAGE 25 SET 4 WITH 385 OF 385 ITEMS DESCRIPTORS HELO TERMS REVIEW YEAR COMBUSTION. AN LC50 OF 28.5 MG/KPLUS/ MINUS 9.25) HAS DETERMINEDt PLACING PVC/ENT SMOKE IN A TOXICITY CATEGORY COMPARABLE TO SHOKE FROM WOOD. FOUR URGE-SCALE TESTS WERE CONDUCTED IN A 21, 734-L ROOM (8X12X8m. IN TESTS INVOLVING 18 TO 30 LINEAR INCH OF PVC/ENT WITH AND WITHOUT FUEL-CONTRIBUTING HEAT SOURCES, IT WAS LEARNED THAT : A)30 IN. OF PVC/ENT DEVELOPED A 3.3-MG/L SMOKE CONCENTRATION AND AN INSUFFICIENT HCL CONCENTRATION TO CAUSE DEATH OR SIGNIFICANT SYMPTOMS IN TEST ANIMALS (RATS) AND B) IN THE PRESENCE OF A REUTIVELY SMALL FIRE (5-LB WOOD CRIB)HEAT AND CARBON MONOXIDE 8ECAME LIFp LIMITING PRIOR TO HCL. IN ADDITIONAL TESTS INVOLVING APPROXIMATELY 60 IN. OF PVC/ENT DEGRADED UNDER 2.5 WATTS/ CM2 HEAT FLUX, A SMOKE CONCENTRATION OF 7.6 MG/L WAS DEVELOPED. ANIMAL FATALITIES IN THESE TESTS WERE SHOWN TO BE FROM HEAT STRESS RATHER THAN SMOKE INHALATION. THE MEASURABLE PERCENTS OF THEORETICAL YIELD OF HCL IN SMALL-SCALE TESTS RANGED FROM 64 TO 96 PERCENT AND IN LARGE-SCALE TESTS FROM 23 TO 50 PERCENT. THE REASONS FOR THESE DIFFERENCES ARE DISC9SSED. ******* COMBUSTION;TOXICITY5THERMAL DECOMPOSITION5WOOD;ACUTE{RATS!EFFECTS;PVCi HYDROGEN CHLORIDE) SMALL SCALE TESTS; J OF FIRE SCIENCES! CONDUIT!LARGE SCALE TESTS! 1990 ITEM 64 ACCESSION NUMBER 1777 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT EVALUATION OF THE PULMONARY EFFECTS OF MOOD SHOKE IN GUINEA PIGS BY REPEATED COB CHALLENGES AUTHOR/AFFILIATION WONG KL.UNIV OF PITTSBURGH!STOCK MFSAMESMALEK DEFAME! AURIE Y,SAME! ORIGIN TOX AND APPLIEO.VOL 75 PP.69-80! DATE 1984 ABSTRACT MALE, ENGLISH SMOOTH HAIREO GUINEA PIGS HERE EXPOSED TO THERMAL DECOMPOSITION PRODUCTS, I.E., SMOKE, GENERATED BY HEATING DOUGLAS FIR IN AN OPEN SYSTEM. VARIOUS AMOUNTS OF DOUGUS FIR WERE PLACED IN A FURNACE, AT ROOM TEMPERATURE, AND HEATED AT A RATE OF 11 DEGREES C/M1N UNTIL COMPLETELY DECOMPOSED. MAJOR DECOMPOSITION OCCURRED BETWEEN 160 AND 490 DEGREES C, AND THREE ANIMALS WERE EXPOSEO OWING THIS TIME FOR A PERIOD OF 30 MIN. IMMEDXATLEY BEFORE EXPOSURE AND AT VARIOUS TIMES AFTER EXPOSURE, EACH ANIMAL HAS EVALUATED BY WHOLE-BODY PLETHYSMOGRAPHY TO MEASURE TIOAL VOLUME AND RESPIRATORY FREQUENCY DURING AIR BREATHING AS HELL AS DURING CHALLENGE WITH 10X C02. EXPOSURE TO SMOKE FROM DOUGLAS FIR RESULTEO IN A DIMINISHED VENTILATORY RESPONSE TO 10X C02. COMPARING THE EFFECT OF MOOD SMOKE TO THE EFFECT OF SMOKE FROM POLYVINYLCHLORIOE FROM PREVIOUS EXPERIMENTS WOOO SMOKE WAS FOUNO TO BE 10 TIMES LESS FROM PREVIOUS EXPERIMENTS,HOOD SMOKE MAS FOUND TO BE 10 TIMES LESS POTENT THAN SMOKE FROMPOLYVINYLCHLORIDE AND ANIMALS RECOVERED MUCH MORE RAPIDLY THAN WITH SMOKE FROM POLYVINYLCHLORIDE. DESCRIPTORS ******* COMBUSTIONJTOXICITY{THERMAL DECOMPOSITION!MOOD!PVC!LUNGSEFFECTS! PULMONARY FUNCTIONIGUINEA PIGS! REVIEW YEAR 1995 ITEM 65 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE 1776 GEN PUBLICATION EVALUATION OF THE PULMONARY TOXICITY OF PLASTICIZED POLYVINYL CHLORIDE THERMAL DECOMPOSITION PRODUCTS IN GUINEA PIGS BY REPEATEO C02 CHALLENGES WONG KL.UNIV OF PITTSBURGH!STOCK MF>SAME,ALARIE YC,SAME! TOX AND APPLIED,VOL 70 PP.236-248i 1983 20S3S626 % % MMiiifwir rn> n'PY inurs PRINTOUT FOR ARY JONES ORDER NUMBER 660827-135259-WIZ -001-001 PAGE 26 SET 4 WITH 365 OF 385 ITEMS ABSTRACT DESCRIPTORS REVIEW YEAR MALE GUINEA PIGS HERE EXPOSED TO THERMAL DECOMPOSITION PRODUCTS OF PLASTICIZED POLYVINYL CHLORIDE (PVC-AI AT DIFFERENT CONCENTRATIONS UP TO LEVELS INDUCING ACUTE LETHALITY. SEVERAL GROUPS EXPOSED AT SUBLETHAL LEVELS,WIRE THEN EVALUATED FOR PULMONARY PERFORMANCE FOR A PERIOD OF 57 DAYS FOLLOWING EXPOSURE. PULMONARY PERFORMANCE NAS EVALUATED BY CHALLENGING EACH ANIMAL WITH A MIXTURE CONTAINING 10X C02, 20X 02, AND 70X N2. IN CONTROL ANIMALS, THIS MIXTURE INDUCED AN INCREASE IN BOTH TIDAL VOLUME ANO RESPIRATORY FREQUENCY. THIS HYPERVENTILATORY RESPONSE NAS GREATLY DEPRESSED DURING THE FIRST 3 DAYS FOLLOWING EXPOSURE AND GRADUALLY RETURNED TO NORMAL DURING THE FOLLOWING WEEKS WITH THE EXCEPTION OF THE HIGHEST EXPOSURE GROUP WHICH STILL SHOWED A DIMINISHED RESPONSE 57 DAYS AFTER EXPOSURE. THE PULMONARY TOXICITY INDUCED BY THERMAL DECOMPOSITION PRODUCTS OF PVC-A IS PROBABLY RELATED TO THE VERY LARGE AMOUNT OF HCL RELEASED DURING THERMAL DECOMPOSITION. THE C02 RESPONSE TEST, A NONINTRUSIVE ANO NONINVASIVE METHOD TO EVALUATE PULMONARY PERFORMANCE IN GUINEA PIGS, IS EASILY PERFORMED AND APPEARS TO BE A VERY PROMISING TYPE OF PULMONARY FUNCTION TEST FOR TOXICOLOGICAL EVALUATIONS. **#**## COMBUSTIONJTOXICITYJTHERMAL DECOMPOSITION;PVCI EFFECTS;LUNG?GUINEA PIGS; PULMONARY FUNCTION; 1995 ITEM 66 ACCESSION NUMBER 1775 FILE LOCATION GEN OOCUMENT TYPE TOXICITY STUDY TITLE OR SUBJECT COMPARATIVE INHALATION TOXICITY OF HEATEO MATERIALS MEASUREO AS EXPOSURE MORTALITY AND POST EXPOSURE MORTALITY AUTHOR/AFFILIATION NONE,none; ORIGIN NONE,REPORT NO. A5I251; DATE 1976, AUGUST 31 ABSTRACT THE COMBUSTION TOXICITY OF PVC ANO WOOO WAS EVALUATED. DESCRIPTORS ******* combustion;toxicity;thermal decomposition;pvc;wooo;effects;acute; rats HELD TERMS GEON 67234SSMALL SCALE TESTS; REVIEW YEAR 1995 ITEM 67 ACCESSION NUMBER 1774 FILE LOCATION GEN OOCUMENT TYPE TECHNICAL REPORT TITLE OR SUBJECT COMBUSTION TOXICOLOGICAL TESTING - PART 5s EVALUATION OF A SERIES OF SYNTHETIC AND NATURAL PRODUCTS BASED ON INCAPACITATION RESPONSE AND ANALYTICAL COMBUSTION GAS DATA AUTHOR/AFFILIATION smith gf,bfg;bachtel wc,bfg-akron; ORIGIN BFG-CHEMICAL DATE 1977, AUGUST 10 ABSTRACT BASEO ON THE MASS OF MATERIAL WHICH INOUCES 50X INCAPACITATION, THE MATERIALS ARE RANKED AS FOLLOWS (BEST PERFORMING MATERIAL LISTED FIRST); GEON 6750 > ESTANE 56360 > POLYCHLOROPRENE > WOOD > GEON 8750 PLUS ZFC > POLYCHLOROPRENE PLUS ZFC. D ESCHIPTORS HELO TERMS REVIEW YEAR ******* combustion;toxicity;thermal decomposition;pvc;polychloroprene; wood;zinc;effects;rats;acute; ZINC FERROCYANIDE;SMALL SCALE TESTSiGEON 8750;ESTANE 58360! 1995 ITEM 68 20838027 SO \T> o PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-MIZ -001-001 PAGE 27 SET 4 WITH 385 OF 385 ITEMS ACCESSION NUMBER FILE LOCATION GEN DOCUMENT TYPE TECHNICAL REPORT TITLE OR SUBJECT COMBUSTION TOXICOLOGICAL TESTING - PART 4: EVALUATION OF HI-TEHP COMPOUNDS BASED ON INCAPACITATION RESPONSE AND ANALYTICAL GAS DATA AUTHOR/AFFILIATION SMITH gfbfg;bachtel wcbfg-akron ORIGIN BFG-CHEMICAL DATE 1978, APRIL 6 ABSTRACT THE PERFORMANCE OF CPVC NITH LON RESIDUAL CCL4 IS ESSENTIALLY EQUIVALENT TO THE PERFORKANE OF GEON 8750 (RIGID PVC). THE PERFORMANCE OF CELLULAR VINYL IS SUPERIOR TO THAT OF CELLULAR CPVC WITH HIGH RESIDUAL CCL4. D ESCRIPTORS ******* combustion;toxicity;therhal oecomposition;cpvc;rats;effects;acute; HELD TERMS HI-TEMP;GEON S750;small scale tests; REVIEW YEAR 1995 ITEM 69 ACCESSION NUMBER 1772 FILE LOCATION GEN DOCUMENT TYPE TECHNICAL REPORT TITLE OR SUBJECT COMBUSTION TOXICOLOGICAL TESTING - PART 3: EVALUATION OF MATERIALS BASED ON INCAPACITATION RESPONSE AND ANALYTICAL GAS DATA AUTHOR/AFFILIATION smith gf,bfg-akron;bachtel uc,bfg-akron: ORIGIN BFG-CHEMICAL DATE 1976 0ECEMBER 23 ABSTRACT BIOASSAY TEST RESULTS DEMONSTRATE THAT RIGID 87235 AND FLEXIBLE 84295 ARE SUPERIOR TO THE CURRENT STANOARD MATERIALS, GEON 8750 AND FLEXIBLE 8737. DESCRIPTORS ******* combustion;toxicity;thermal oecomposition;pvc;rats;effects; wooducute; HELD TERMS GEON 87235`iGEON 84295;GE0N 6750;GEON 8737JSMALL SCALE TESTS; REVIEW YEAR 1995 ITEM 70 ACCESSION NUMBER 1771 FILE LOCATION GEN DOCUHENT TYPE TECHNICAL REPORT TITLE OR SUBJECT COMBUSTION TOXICOLOGICAL TESTING - PART 2! COMBINED BIOLOGICAL RESPONSE AND ANALYTICAL 6AS DATA ON 12 KEY MATERIALS AUTHOR/AFFILIATION O'HARA mm,bfg-chemical;bachtel wc.bfg-akron; ORIGIN BFG-CHEMICAL DATE 1976, APRIL 27 ABSTRACT THE AUTHORS COMPAREO MOOD AND SELECTED SYNTHETIC PRODUCTS. THEY FOUND THAT RESULTS VARY DEPENDING ON THE METHOD OF COMBUSTION. DESCRIPTORS ******* combustion;toxicity;thermal decomposition;pvc;mood;cpvc;rats; acute; HELD TERMS 6E0N 6750;small scale tests;hi-temp; REVIEW YEAR 1995 ITEM 71 ACCESSION NUMBER 1770 20898028 V 'S) r >' r A n y 208;; ;n:^n PRINTOUT FOR GARY JONES OROER NUMBER 660627-135259-UIZ -001-001 PAGE 20 SET 4 WITH 385 OF 365 ITEMS FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT AN EVALUATION OF A SERIES OF NATURAL AND SYNTHETIC MATERIALS BY INCAPACITATION BIQASSAY TESTING A SPECIAL REPORT TO THE NATIONAL BUREAU OF STANDARDS AUTHOR/AFFILIATION SMITH GFiBFG-AVON LAKE; ORIGIN BFG-AVON LAKEiFOR NATIONAL 8UREAU OF STANDARDS? DATE 1977, SEPTEMBER ABSTRACT THE COMBUSTION TOXICITY OF PVC,PVC/ZINC FERROCYANIDE, POLYCHLOROPRENE,POLYCHLOROPRENE ZINC FERROCYANIDE, POLYURETHANE AND HOOD WERE STUDIED. BASED ON INCAPACITATION ,PVC NAS ONE OF THE LEAST TOXIC MATERIALS TESTED. DESCRIPTORS **# combustion;toxicity;thermal oecomposition;pvc;polychloroprene; wood;rats;effects;acute; HELD TERMS zinc ferrocyanide;polyurethanes;small scale tests; REVIEW YEAR 1995 ITEM 72 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS #*#*** HELD TERMS REVIEW YEAR 1769 GEN TECHNICAL REPORT RELATIVE PERFORMANCE OF GEON 6750,87234 AM) 87235 IN COtCUSTION- BIOASSAY PROTOCOLS O'MARA MM,BFG-AVON LAKE; BFG-AVON LAKE 1976, OCTOBER 22 THE COMBUSTION TOXICITY OF PVC,WOOD AND PVC COMPOUNDS HERE EVALUATED. COMBUSTION {TOXICITY 5 THERMAL DECOMPOSITION *, PVC {RATS * EFFECTS! ACUTE 5 UOOO J SMALL SCALE TESTSSGEON 67234!GE0N 87235{6EON 6750! 1995 ITEM 73 ACCESSION NUMBER 1768 FILE LOCATION GEN DOCUMENT TYPE TOXICITY STUDY TITLE OR SUBJECT COMPARATIVE INHALATION TOXICITY OF HEATED MATERIALS MEASURED AS INCAPACITATIONEXPOSURE MORTALITY AND POST EXPOSURE MORTALITY AUTHOR/AFFILIATION NONE,NONE! ORIGIN NONE.FOR BFG REPORT NO.02077; OATE 1977, APRIL 20 ABSTRACT THE COMBUSTION TOXICITY OF PVC,NOOD AND WOOL WAS EVALUATED. DESCRIPTORS *** COMBUSTION JTOXICITYiTHERMAL DECOMPOSITION5 PVCJWOOD} RATS5 EFFECTS{ACUTE! HELD TERMS U.S.TESTING CO.SMALL SCALE TESTS{GEON 8750! WOOL! REVIEW YEAR 1995 ITEM 74 ACCESSION NUMBER FILE LOCATION OOCUMENT TYPE TITLE OR SUBJECT 1767 GEN TOXICITY STUDY COMPARATIVE INHALATION TOXICITY OF HEATED MATERIALS MEASURED AS INCAPACITATION,EXPOSURE MORTALITY AND POST EXPOSURE MORTALITY G 5^S 20838029 I PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-MIZ >001-001 PAGE 29 SET 4 WITH 305 OF 385 ITEMS * X: /-4%. AUTHOR/AFFILIATION NONE,NONE? X* *" ` ORIGIN NONE,FOR BF6 REPORT NO.A51192J OATE 1976, JULY 13 ABSTRACT THE COMBUSTION TOXICITY OF PVC.PVC/ZINC FERROCYANIDE, AND SEVERAL PVC C0MP0UWJ3 HAS STUDIED. DESCRIPTORS ***### PVC;COMBUSTION;TOXICITY5THERMAL DECOMPOSITIONSRATSiEFFECTSl ACUTE) HELO TERMS U.S.TESTING COfZINC FERROCYANIOEJGEON 8750)GE0N 87235) 6E0N 8737;6E0N 842955SMALL SCALE TESTS) REVIEW YEAR 1995 ITEM 75 ACCESSION NUMBER 1765 FILE LOCATION GEN DOCUHENT TYPE TECHNICAL REPORT TITLE OR SUBJECT RESULTS OF THE EXPOSURE OF TEST RATS TO THE COMBUSTION PRODUCTS FROM B.F.G.C.C. PRODUCTS AUTHOR/AFFILIATION O'HARA M.BFG-CHEMICAi; ORIGIN BFG-CHEMICAL DATE 1975, OCTOBER 27 ABSTRACT THIS REPORT PRESENTS A SUMMARY OF THE BACKGROUND LEADING UP TO OUR FIRST ANIMAL COMBUSTION-EXPOSURE EXPERIMENTS, THE CURRENT PHILOSOPHY BEHIND THIS KIND OF TESTING AND CURRENT LIMITATIONS NITH THE TESTING. TWELVE KEY MATERIALS INVOLVING THE FOLLOWING PRODUCT LINES (ESTANE, ABSQNPVCHI-TEMP) WERE CHOSEN FOR THIS INITIAL EVALUATION. ALL EXPERIMENTS MERE CARRIEO OUT AT U.S. TESTING USING A MODIFICATION OF THEIR TESTING PROTOCOL. IN SUMMARY, TEN OUT OF THE TWELVE SUBMITTED MATERIALS PERFORMED HORSE THAN WOOD. ONE SMOKE RETARDED PVC FORMULATION MAS MUCH SUPERIOR TO WOOD. AN ANALYSIS OF THE DATA INDICATES THAT 5 OUT OF THE 10 MATERIALS WERE WORSE THAN WOOD BECAUSE OF THE AMOUNT OF COMBUSTION PRODUCTS PRO0XED) THE REMAINING 5 SAMPLES WERE DESCRIPTORS HELD TERMS WORSE THAN WOOD BECAUSE OF THE KINDS OF COMBUSTION PROOUCTS PRODUCED. ******* combustion;toxicity;pvc;thermal oecomposition;mood;rats;effects; acute; ESTANE X430)SMALL SCALE TESTSABSON 89129;A8S0N 820X16; GEON 6750;GEQH 6804 BLACK 268;GE0N 8737 BLACK 289)6E0N 3010;GEON 85721 NATURAL 020; REVIEW YEAR 1995 ITEM 76 ACCESSION NUMBER 1762 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT TOXICOLOGIC EVALUATION OF THERMOPLASTIC RESINS AT AND ABOVE PROCESSING TEMPERATURES AUTHOR/AFFILIATION ORIGIN SANGHA GK.UNIV OF PITTSBURGH*,MATIJAK M,SAME;ALARIE Y,SAME5 AIHAiVOL 42 PP.481-485; DATE 1981 ABSTRACT SENSORY IRRITATION AND ACUTE LETHALITY CAUSED BY FUMES EMANATING FROM A VARIETY OF THERMOPLASTICS WERE EVALUATED USING MICE. THE MATERIALS WERE SUBJECTED TO TEMPERATURE RANGES FROM MELT PROCESSING AND ABOVE. ALL MATERIALS RELEASED IRRITATING FUMES WITH INCREASING TEMPERATURES AND ACUTE LETHALITY,PRINCIPALLY DUE TO RELEASE OF CARBON MONOX10E,OCCURRED AT ELEVATED TEMPERATURES. DESCRIPTORS ******* COMBUSTIONJTOXICITYJTHERMAL DECOMPOSITION!MICEJPVC;ACUTE5EFFECTS; HELD TERMS KWIC INDEX NUMBER REVIEW YEAR NATURALPRODUCTSSYNTHETIC PRODUCTS;SMALL SCALE TESTS; 04820 / 1995 / 20896030 O' o* 1 in 4o ......... . f " <'M'Y l"! 'rr : i .* PRINTOUT FOR GARY JONES ORDER NUMBER 660627-135259-WIZ -001-001 PAGE 30 SET 4 WITH 365 OF 365 ITEMS ITEM 77 ACCESSION NUMBER 1757 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT TECHNICAL REPORT THE CORRELATION OF ANIMAL RESPONSE DATA WITH THE YIELDS OF SELECTED THERMAL DECOMPOSITION PROOUCTS FOR TYPICAL AIRCRAFT INTERIOR MATERIALS:FINAL REPORT AUTHOR/AFFILIATION SPURGEON JC.NONE; ORIGIN DATE ABSTRACT NTIS,REPORT NO.FAA-RD-78-13I5 1978, NOVEMBER THE AUTHOR COMPARED THE COMBUSTION TOXICITY OF MANY MATERIALS. PVC MAS LESS TOXIC THAN MANY AND COMPARABLE TO OR MORE TOXIC THAN SOME. DESCRIPTORS ******* combustion;toxicity;thermal decomposition;pvc;rats;effects; acute; HELD TERMS NATURAL PRODUCTS;SYNTHETIC PR00UCTS;SMALL SCALE TESTSJFAA; FEDERAL AVIATION ADMINISTRATION; KWIC INDEX NUMBER 04135 REVIEW YEAR 1995 ITEM 78 ACCESSION NUMBER 1754 FILE LOCATION GEN OOCUMENT TYPE PUBLICATION TITLE OR SUBJECT ASSESSMENT OF THE RELATIVE TOXICITY OF MATERIALS! CONCEPT OF A LIMITING TOXICANT AUTHOR/AFFILIATION ORIGIN petajan jHUNiv of utah;balduin rcsame;rose rf,same; jeppsen rbsame; NONE,ASTM STP 614 PP.285-299; DATE 1977 ABSTRACT EXPERIMENTS WERE CONDUCTED ON MALE LONG-EVANS RATS INSTRUMENTED FOR MEASUREMENT OF VITAL FUNCTIONS ANO A CONDITIONED AVOIDANCE RESPONSE. AN INTRA-ARTERIAL CANNULA NAS USED FOR REMOVAL OF BLOOD SAMPLES. RATS MERE EXPOSED TO COMBUSTION PROOUCTS OF THREE POLYMERIC MATERIALS. A NATIONAL BUREAU OF STANDARDS SMOKE CHAMBER AND A SMALLER "STATIC" CHAMBER MERE USED FOR EXPOSURES. MATERIAL A PRODUCED A SYNDROME OF CARBON HONOXIDE (CO)-INDUCED ANOXIA, THE SEVERITY OF WHICH DEPENDED ONLY UPON THE AMOUNT OF MATERIAL DEGRADED AND NOT UPON THE MODE OF COMBUSTION (HEATrFLUX, FLAMING,OR NONFLAMING). MATERIAL B PROOUCEO A SYNDROME OF EPILEPSY AND CARBOXYHEMOGLOBIN LEVELS BELOW 10 PERCENT. MATERIAL C PROUOCEO A METABOLIC ACIOOSIS AND MILD CO- INDUCEO ANOXIA, THE SEVERITY OF WHICH WAS RELATED TO THE AMOUNT OF MATERIAL DE6RADED, IRRESPECTIVE OF THE COMBUSTION MODE. THE COMBUSTION PRODUCTS OF MATERIALS B AND C PRODUCED INTOXICATION SYNOROMES DISTINCTLY DIFFERENT FROM THE SYNDROME OF CO-INOUCEO ANOXIA PRODUCED BY MATERIAL A. "LIMITING" TOXICANTS OR SUBSTANCES WITH HIGH BIOLOGICAL ACTIVITY MAY BE PRESENT IN COMBUSTION PRODUCTS AND PRODUCE UNIQUE INTOXICATION SYNOROMES. DESCRIPTORS ******* cohdustion;toxicity;thermal decomposition;pvc;rats;effects; acute; HELD TERMS REVIEW YEAR small scale tests;astm;american society for testing a materials; fire standards and safety; 1995 ITEM 79 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 1753 GEN PAPER .*' TOXICITY OF THERMAL DECOMPACTION PROOUCTS FROM COMMONLY USED SYNTHETIC POLYMERS # 20S33031 % I PRINTOUT FOR GARY JONES ORDER NUMBER 860627-135259-WIZ -001-001 PAGE 31 SET 4 WITH 365 OF 365 ITEMS AUTHOR/AFFILIATION MATIJAK-SCHAPER PITTSBURGH fSTOCX MFiSAMEt ALARIf ORIGIN NONE,NONE! DATE 1982, DECEMBER ABSTRACT THE AUTHORS REPORfSWlE RESULTS OF COtBUSTION TOXICITY FOR CARPET,PVC,FLOOR TILE*, PLASTIC *******DESCRIPTORS PIPE,WIRING,PTFEySIND FOAM SAMPLES. , combustion;toxiczty;thermal decomposition; pvc; mice {effects; acute; HELO TERMS SMALL SCALE TfRTS5SYNTHETIC PRODUCTS! REVIEW YEAR 1995 * ITEM 60 ACCESSION NUMBER 1752 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT A SEMI-QUANTITATIVE METHOD FOR ASSESSING ANATOMIC DAMAGE SUSTAINED BY THE UPPER RESPIRATORY TRACT OF THE LABORATORY MOUSE,MUS MUSCULIS AUTHOR/AFFILIATION LUCIA HLiUNIV OF PITTSBURGHBARROW CS.SAMEJSTOCK MFtSAME! ALARIE Y,SAME! ORIGIN J OF COMBUSTION TOXICOLOGY,VOL 4 PP.472-466! DATE 1977, NOVEMBER ABSTRACT STANDARDIZED METHODOLOGY WAS DEVELOPED AND USED TO EVALUATE THE EFFECTS ON THE UPPER RESPIRATORY OF MICE FOLLOWING EXPOSURE TO THERMAL DECOMPOSITION PROOUCTS OF VARIOUS POLYMERS. THE RESULTS OBTAINED JUSTIFY THE FOLLOWING RATING FOR THE POLYMERS TESTED FROM MOST TO LEAST POTENT* POLYTETRAFLUOROETHYLENE, POLYVINYL CHLORIOE > POLYURETHANE,DOUGLAS FIR > FIBER GLASS REINFORCED POLYESTER. INJURT OBTAINED WITH POLYVINYL CHLORIOE MAS VERY SIMILAR TO THAT PRODUCED BY HYDROGEN CHLORIDE. DAMAGE WITH PURE HCL GAS APPEARS GREATER THAN AMOUNT OF PVC WHICH WOULD HAVE PRODUCED AN ESTIMATEO EQUIVALENT AMOUNT OF HCL. DESCRIPTORS ******* combustion;toxicity;thermal decomposition;pvc;mice;effects; hydrogen chloride;wooo;pathology; lung:RESPIRATORY TRACT! HELO TERMS SMALL SCALE TESTS}SYNTHETIC PRODUCTS; NATURAL PRODUCTS! REVIEW YEAR 1995 ITEM 81 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ******* HELD TERMS REVIEW YEAR 1751 GEN PUBLICATION TOXICITY OF PUSTIC COMBUSTION PRODUCTS. III. RAPID EVALUATION HETHOO LD50 IN MICE le moan g,none;chaigneau m,none; NONE,VOL 35 NO.11-12 PP.461-464, 1977 PVC WAS ONE OF THE LEAST TOXIC MATERIALS TESTED. combustion;toxicity;thermal decomposition;pVc;effects;mice; ACUTE! SYNTHETIC PRODUCTS!SMALL SCALE TESTSiANNALES PHARM FRANC! 1995 BY DETERMINATION OF THE ITEM 82 ACCESSION NUMBER FILE LOCATION 1749 GEN 20838032 ! i PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-WIZ -001-001 PAGE 32 SET 4 WITH 385 OF 385 ITEMS DOCUMENT TYPE JOURNAL TITLE OR SUBJECT EPIDEMIOLOGICAL STUDY OF THE LUNG FUNCTION OF WORKERS AT A FACTORY MANUFACTURING POLYVINYLCHLORIDE AUTHOR/AFFILIATION LLOYD MNiNONEiGAULD S.NONEJCOPLAFC LNONEJSOUTAR CA,NONET' C ORIGIN NONE.VOL 41 PP.328-333; DATE ABSTRACT 1984 A PRELIMINARY EPIDEMIOLOGICAL STUDY HAS BEEN CARRIED OUT TO INVESTIGATE A REPORT THAT SOME MEN WORKING IN A FACTORY MANUFACTURING POLYVINYLCHLORIDE (PVC) HAD ABNORMALLY LOW VALUES OF THE SINGLE BREATH DIFFUSING CAPACITY FOR CARBON MONOXIDE (TLCO). ALL 265 PRESENT AND PAST EMPLOYEES OF THE PVC FACTORY WERE STUDIED. TOGETHER WITH 219 MEN FROM THE WORKFORCE OF A NEARBY FOUNDRY. EACH MAN'S TLCO WAS MEASURED AND A SMOKING HISTORY AND DETAILED OCCUPATIONAL HISTORY OBTAINED. THE DISTRIBUTION OF STANDARDISED TLCO RESULTS FROM ALL PERSONS EXAMINED WAS SYMMETRICAL AND DID NOT INOICATE AN UNEXPECTEDLY HIGH PROPORTION OF MEN WITH CLINICALLY IMPORTANT IMPAIRMENT OF TLCO. THE RESULTS OF A CASE-CONTROL STUDY SHOWED THAT.HAVING ALLOWED FOR AGE.HEIGHT.WEIGHT.AND SMOKING HABIT,TLCO WAS ASSOCIATED WITH A HISTORY OF WORKING IN THE PVC FACTORY BEFORE 1975 (WHEN LEVELS OF VINYLCHLORIDE MONOMERS (VCMI WERE MUCH HIGHER THAN SUBSEQUENTLY). AND SLIGHTLY ASSOCIATED WITH WORKING IN JOBS WHERE EXPOSURE TO VCM HAS LIKELY TO HAVE BEEN HIGHEST. THE MEN Will) LOW TLCO ALSO TENDED TO HAVE SMOKED MORE HEAVILY THAN CONTROLS. THE RELATIVE IMPORTANCE OF OCCUPATIONAL FACTORS AND SMOKING IN RELATION TO'LOW TLCO IS NOT CLEAR. BUT THE RESULTS GIVE SOME SUPPORT TO THE HYPOTHESIS THAT WORK IN THE PVC FACTORT BEFORE 1975 ENTAILED EXPOSURE TO A SUBSTANCE THAT CAUSED IMPAIRMENT OF LUNG FUNCTION IN A SMALL NUMBER OF MEN. DESCRIPTORS ******* polyvinyl chloride ;puu4onary function;epidehiology;lungs;effects;humans; HELD TERMS BRITISH J OF INDUSTRIAL MEDICINE) COMMENTS RKH(85) FULL TEXT AND COMMENTS BY GEOFF PADDLE ARE ATTACKEO. REVIEW YEAR 1995 ITEM 83 ACCESSION NUMBER 1748 , FILE LOCATION GEN < DOCUMENT TYPE STANDARDS TITLE OR SUBJECT CONTROL OF SUBSTANCES HAZARDOUS TO HEALTH REGULATIONS:CONTROL OF VINYL CHLORIDE AT WORK (DRAFT APPROVED CODE OF PRACTICE) AUTHOR/AFFILIATION NONE,none; ORIGIN HEALTH AND SAFETY EXECUTIVE.UNITED KINGDOM HEALTH A SAFETY COMMISSION; DATE 1984 DESCRIPTORS ******* VINYL CHLORIDE MONOMER;OCCUPATIONAL EXPOSURE; REVIEW YEAR 1987 ITEM 84 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 1747 GEN REPORT NIOSH STUDIES WHERE INDUSTRY AND/OR OCCUPATIONAL GROUPS ARE INVESTIGATED NONE,none; NATIONAL INSTITUTE OF OCCUPATIONAL SAFETY AND HEALTH 1984 THESE ARE ONE PAGE SUMMARIES OF EPIDEMIOLOGY STUDIES. THEY HAVE BEEN USED BY RALPH NAOER TO SHOW CONGRESS EXAMPLES OF INSTANCES* WHERE INDUSTRY HAS CONDUCTED RESEARCH BUT HAS NOT NOTIFIED THE 20838033 vA o ! PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-UIZ -001-001 PAGE 33 SET 4 WITH 385 OP 365 ITEMS DESCRIPTORS REVIEH YEAR wuKi\crca. ^ ******* VINYL CHLORIDE MONOMER.EPIDEMIOLOGY.HUMANS.EFFECTS.NATIONAL INSTITUTE OP OCCUPATIONAL SAFETY AND HEALTH; 1990 , -g ' ,> 'ITEM 85 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT X719 SEN PAPER WORKING CONDITIONS AND MEASURES FOR THEIR SANITATION IN THE PRODUCTION AND UTILIZATION OF VINYL AUTHOR/AFFILIATION CHLORIDE PLASTICS TRIDUKH SL.NONE{TIKHOMIROVA NP.NONE)LEVIN SV.NONE? KOZLOV,NONE5 ORIGIN ARG SANIT.VOL 10 PP.38-45? DATE ABSTRACT 1949 THIS DOCUMENT IS OFTEN QUOTED BY LAWYERS AS EARLY EVIDENCE OF VCM CAUSING LIVER DAMAGE. HOWEVER. OTHER THINGS SUCH AS PCB'S COULD ACCOUNT FOR ILLNESS OBSERVED. DESCRIPTORS #**#** VINYL CHLORIDE MONOMER.CANCER5HUMANS;EFFECTS?LIVER > HELD TERMS ACAOEMY OF MEDICAL SCIENCES (USSR); REVIEW YEAR 1998 ITEM 66 ACCESSION NUMBER 1718 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT OCCUPATIONALHAZARDS OF VINYLCHLORIDE ANDSTYRENE AUTHOR/AFFILIATION NICHOLSON WJ.CITY UNIV OF NEW YORK{HENNEBERGER PK.SAME; SEIOMAN H.SAME.TARR O.SAME; ORIGIN NONE,VOL 141 PP.45-78 155-176 263-278; OATE 1984 ABSTRACT ARTICLES PUBLISHED OISCUSS "TRENDS IN CANCER MORTALITY AMONG WORKERS IN THE SYNTHETIC POLYMERS INDUSTRY (PP.65-78) 5"OCCUPATIONAL HAZARDS IN THE VC-PVC INDUSTRY (PP. 155-176'.OCCUPATIONAL HAZARDS IN PRODUCTION OF PROCESSING OF STYRENE POLYMERS--EPIDEMIOLOGIC FINDINGS (PP.263-278).11 DESCRIPTORS **** VINYL CHLORIDE MONOMER{STYRENE?CANCER;HUMANS>EFFECTSiEPIOEMIOLOGY> HELD TERMS PROGRESS IN CLINICAL AND.BIOLOGICAL RESEARCH; COMMENTS MNJ(85I QUESTIONS THECLAIM THAT VCMCUASES LUNG CANCER. REVIEW YEAR 1990 ITEM 67 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 1711 GEN PUBLICATION GENETIC SUSCEPTIBILITY TO SCLERODERMA-LIKE SYNDROME INDUCED BY VINYL CHLORIDE BLACK CM.NONE.WALKER AE.NONE.CATQGGIO LJ,NONE!WELSH KI.NONEJ BERNSTEIN RM,NONE{MCGREGOR AR.{ JONES jkl.none; N0NE.PP53-55; 1983 VINYL CHLORIDE (VC) MONOMER CAN INDUCE A SCLEROOERMA-lIKE SYNOROME IN A PROPORTION OF WORKERS EXPOSED TO IT DURING PRODUCTION OF POLYVINYL CHLORIDE. AS PART OF A 5-YEAR FOLLOW-UP STUDY HLAA A. 0511 20S38034 ! M | f.niy K'l !l PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-WIZ -001-001 PAGE 34 SET 4 WITH 385 OP 385 ITEMS DESCRIPTORS HELD TERMS REVIEW YEAR B, AND DR ANTIGENS AND ANTI-CENTROMER And ANTI-SCLERODERMA-70 ANTIBODIES HERE DETERMINED IN 44 SUCH WORKERS. El OP THESE HAO SEVERCHnD S3 MILD FORMS OF VINTL-CHLORIOE DISEASE. 50 PATIENTS WITH "CLASSICAL" SCLERODERMA AND 148 HEALTHY HOSPITAL NORKERS ACTED AS CONTROLS. 11 OF THE 21 PATIENTS CLASSIFIED AS HAVING SEVERE VC DISEASE HERE DR3 POSITIVE.AND 8 OF THESE HAO BOTH B8 AND DR3 ANTIGENS. NONE OF THE 23 PARENTS WITH MILD DISEASE CARRIED EITHER ANTIGEN. THE HLA-ANTIGEN FREQUENCIES IN VC DISEASE MIRRORED THOSE FOUND IN SCLERODERMA (RAISED DR5 FREQUENCY AND INCREASED LINKAGE DISEQUILIBRIUM BETWEEN" B8 AND DR3). THERE WERE.HOWEVER.SIGNIFICANT DIFFERENCES IN THE FREQUENCY OF AUTOANTIBODIES IN THE TWO CONDITIONS. ******* SCLERODERMA.VINYL CHLORIDE MONOMER;HUMANS;EFFECTS; THE LANCETiGUY'S HOSPITAL(LONDON)>HAMMERSMITH HOSPITAULONDON); 1990 ITEM 88 ACCESSION NUMBER 1703 FILE LOCATION GEN OOCUMENT TYPE PUBLICATION TITLE OR SUBJECT HEPATIC ANGIOSARCOMA FROM VINYL CHLORIDE. REPORT OF A NEW ITALIAN CASE AUTHOR/AFFILIATION CHIAPPINO g,none;bertazzi pa.none.baroni m.none;masini t.none; ORIGIN NONE.VOL 6 PP.555-563; DATE 1982 ABSTRACT THE FOURTH CASE OF ANGIOSARCOMA OF THE LIVER AMONG WORKERS EXPOSED TO VINYL CHLORIDE IN ITALY IS REPORTED. THE CASE WAS A 43 YEARS OLD MAN WHO WORKED FROM 1959 TO 1980 IN A VCM/PVC PRODUCTION PLANT. MOSTLY IN THE POLYMERIZATION AREA. HE DIED IN MARCH 1961. FOUR MONTHS AFTER DIAGNOSIS,FOR A MASSIVE HAEMOPERITONEUM; POST MORTEM EXAMINATION WAS PERFORMED. ACCORDING TO FOUR INDEPENDENT PATHOLOGISTS THE HISTOLOGIC APPEARANCE WA5 TYPICAL OF A HIGHLY DEVIATING ANGIOSARCOMA. THE TUMOR DEVELOPED AFTER A SCLEROTIC LIVER LESIONS NAS ALREADY PRESENT. THE ANGIOSARCOMA WAS PROBABLY POLYCENTRIC. HAO A HIGH DEGREE OF MALIGNANCY ANO A RAPID LOCAL EVOLUTION WHILE.IN CONTRAST, NO METASTA5ES WERE DETECTED. DESCRIPTORS ******* ANGIOSARCOMA;VINYL CHLORIDE MONOMERIHUMANS;EFFECTSi HELD TERMS MED LAVORO; REVIEW YEAR 1990 ITEM 89 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 1701 GEN PUBLICATION DRUG-INDUCED VASCULAR LESIONS OF THE LIVER ZAFRANI ES,NONE;PINAUDEAU Y,NONE;OHUMEAUX D.NONE5 NONE.VOL 143 PP.495-5025 1983. MARCH THE VASCULAR LESIONS OF THE LIVER DESCRIBED IN ASSOCIATION WITH DRUG AND TOXIC SUBSTANCE EXPOSURE ARE REVIEWED WITH SPECIAL REFERENCE TO THE ABNORMALITIES OF THE FOLLOWING:(1) THE HEPATIC VENOUS EFFERENT SYSTEM (IE.LARGE AND SMALL HEPATIC VEIN OBSTRUCTION);(2) THE SINUSOIDS (IE.SINUSOIDAL DILATATION, PEtlOSIS.PERISINUSOIOAL FIBROSIS)! (3) THE PORTAL VEIN AND ITS BRANCHES; ND (4) THE HEPAITC ARTERIAL TREE. DRUG-INDUCED VASCULAR TUMORS OF THE LIVER ANO VASCULAR CHANGES OBSERVED NJttlN NONVASCULAR TUMORS OF THE LIVER ARE ALSO ENVISAGED. FINALLY, THE PATHOPHYSIOLOCIG MECHANISMS?OF ALL THESE LESIONS ARE CONSIDERED. THE AWARENESS OF THIS TYPE OF HEPATOTOXICITY ANO THE KNOWLEDGE OF ITS EPIDEMIOLOGY SEEM TO BE ESSENTIAL FOR BOTH ITS EARLY 20838035 \ I PRINTOUT FOR GARY JONES OROER NUMBER B60827-135259-WIZ -001-001 PAGE 35 SET A WITH 365 OF 365 ITEMS DESCRIPTORS HELD TERMS REVIEW YEAR DETECTION AND PREVENTION. **** VINYL CHLORIDE MONOMER{LIVER(EFFECTS.ANGIOSARCOMA, BUDD-CHIARI SYNDRONEjVENQ-OCCU/SIVE OISEASEJPELIOSIS HEPATlS! ARCH INTERN NEDS 1990 ; "'Ti, ITEM 90 ACCESSION NUMBER FILE LOCATION 1700 GEN DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION PUBLICATION VINYL CHLORIDE-INDUCED HEPATIC LESIONS IN MAN AND RODENTS. A COMPARISON POPPER H.NONE;MALTONI C,NONE;SELXKOFF IJ.CITY UNIV OF NEH YORK; ORIGIN NONE,VOL 1 PP.7-205 OATE ABSTRACT 1951 HISTOLOGIC SEQUENCES IN THE LIVER OF ROOENTS EXPOSED BY INHALATION TO GASEOUS VINYL CHLORIDE HERE COMPARED TO THE LESIONS IN MAN EXPOSED TO THE SAME AGENT* MAINLY IN VINYL CHLORIOE POLYMERIZATION PLANTS. AN IDENTICAL SEQUENCE.STARTING WITH CIRCUMSCRIBED PROLIFERATION OF HEPATOCYTES.SOON FOLLOWED BY PROLIFERATION OF A VARIETY OF SINUSOIDAL CELLS AND FREQUENTLY ASSOCIATED UITH SINUSOIDAL OILATATION,PROGRESSES TO INTRALOBULAR AND MORE FREQUENTLY TO TRABECULAR ANGIOSARCOMA. PREDOMINANTLY IN YOUNG ANIMALS ANO RARELY IN HAN, HEPATOCECCULAR CARCINOMA DEVELOPS, BUT NEVER CIRRHOSIS. THE SEQUENCE REPRESENTS A DYNAMIC PROCESS OF COMPETITION BETHEEN PROLIFERATING HEPATOCYTES AND SINUSOIOAL CELLS, OF HEPATOCYTES WITH FIBROPLASIA,BETWEEN PERISINUSOIOAL FIBROSIS AND SINUSOIDAL DILATATION,AND OF PROLIFERATION OF VARIOUS SINUSOIDAL CELLS VERSUS ANGIOSARCOMA. THE GREAT SIMILARITY IN THE EVOLUTION IN MAN AND RODENTS,RARELY ENCOUNTERED IN OTHER EXPERIMENTAL MODELS, SUPPORTS THE PREDICTION OF HUMAN CANCER FROM ANIMAL EXPERIMENTS. THE PRECURSOR NOQULES DIFFER FROM THE NODULES COWONLY OBSERVED IN HEPATOCARCINOGENESIS BY CO-PROLIFERATION OF SINUSOIDAL CELLS. THE DIFFERENCES IN THE REACTIONS BETWEEN MAN ANO ROOENTS BESPEAK A STRONG FIBROBLASTIC REACTIVITY IN MAN. HOST IMPORTANT, THE PRECURSOR LESION OF MIXEO HEPATOCELLULAR AND SINUSOIDAL CELL PROLIFERATION MAY BE OF DIAGNOSTIC VALUE, BEING SUPERIOR TO CONVENTIONAL HEPATIC TESTS IN DETECTION OF SOME INITIAL ENVIRONMENTAL LESIONS. ,f|- DESCRIPTORS HELD TERMS REVIEN YEAR ***##* VINYL CHLORIDE MONOMER* LIVER{EFFECTS{HUMANSRAT{PATHOLOGY; MICE; LIVER PUBLICATION;INSTITUTE OF ONCOLOGY {ITALY){STRATTON LAB? RODENTS; 1990 ITEM 91 ACCESSION NUMBER 1699 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT AUTHOR/AFFILIATION THE TOXICITT OF VINYL CHLORIDE AS DETERMINED BY REPEATED EXPOSURE OF LABORATORY ANIMALS TORKELSON TR,OOW CHEMICAL CO;OYEN F,SAHE;ROUE VK,SAME{ ORIGIN __DATE AMERICANINDUSTRIAL HYGIENE ASSOCIATION,VOL 22NO.5 PP.354-361; 1961, OCTOBER ABSTRACT GROUPS OF LABORATORY ANIMALS WERE EXPOSED REPEATEDLY FOR UP TO SIX MONTHS TO EITHER 500*200,100 OR 50 PPM VINYL CHLORIDE IN AIR. DETECTABLE CHANGES OCCURRED AT ALL BUT THE LOWEST CONCENTRATION. THE RESULTS ARE DISCUSSED AND HANOLING PRECAUTIONS SUGGESTED. DESCRIPTORS ******* VINYL CHLORIDEMONOMER;EFFECTS;RAT;RABBIT;GU1NEAPIG{SUBACUTE{ REVIEW YEAR 1990 20SS803S % % \ () T" *') '-'Nf-y,.-,,. PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-NIZ -001-001 PAGE 36 SET 4 WITH 3S5 OP 365 ITEMS ITEM 92 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS * HELD TERMS REVIEW YEAR 1698 GEN JOURNAL J RESPIRATORY ILLNESS CAUSED BY OVERHEATING OF' POLYVINYL CHLORIDE FRONEBERG B,NATIONAL INSTITUTE OF OCCUPATJNAL SAFETY AND HEALTH;JOHNSON PL,SAME;LAIORI6AN PJ. same; NONE.VOL 39 PP.239-243; f 1962 ON 9 AUGUST 1979 62 (30.8X) OF 201 WORKERS AND ONE OF 60 MANAGEMENT PERSONNEL IN A POLYVINYL CHLORIDE (PVC) FABRICATING PLANT OEVELOPEO ACUTE UPPER AND LOWER RESPIRATORY IRRITATION. HEADACHE, NAUSEA,AND FAINTING. ALL WERE TAKEN TO HOSPITAL;NONE DIED. SIXTY OF THE PATIENTS HERE WOMEN. INTERVIEWS TWO WEEKS LATER WITH 57 AFFECTED AND 14 UNAFFECTEQ WORKERS DISCLOSED THAT ILLNESS HAO FOLLOWED EXPOSURE TO FUMES FROM AN OVERHEATED (362 DEGREES C) PVC EXTRUDING MACHINE. FUMES MERE EMITTED FROM 1100 UNTIL 1150; .CASES OCCURRED FROM 1100 UNTIL LATE AFTERNOON. ALL WORKERS WHO BECAME ILL WORKED WEST OF THE^OVERHEATED EXTRUDER. AND THE AFFECTED MANAGER HAD VISITED THAT AREA. THE EARLIEST CASES OCCURRED CLOSEST TO THE MACHINE. AND INCIDENCE DECREASED (FROM 53.3X TO 15.4X) WITH DISTANCE WESTWARD. THIS PATTERN HAS CONSISTENT WITH PLANT VENTILATION. INCIDENCE RATES IN MEN AND WOMEN DID NOT DIFFER (P>0.1). AT TWO AND 14 WEEKS, PULMONARY FUNCTION TESTING OF WORKERS WITH PERSISTENT PULMONARY SYMPTOMS SHOWED ABNORMALITIES IN 13 OF 16 AND IN 9 OF 11 RESPECTIVELY;THE GROUP WITH PERSISTENT SYMPTOMS CONTAINED AN EXCESS OF NON-SMOKERS AND OF THOSE WITH PREVIOUS RESPIRATORY ILLNESSES. ONE KILOGRAM OF PVC HEATED TO 300 DEGREES C RELEASES AN ESTIMATED 12.9 G OF HYDROCHLORIC ACID (HCL) AND 4.9 6 OF CARBON MONOXIDE (CO). WE ATTRIBUTED THE OUTBREAK TO EXPOSURE TO TOXIC HCL AND CO AND REJECTED THE HYPOTHESIS OF MASS PSYCHOGENIC ILLNESS. POLYVINYL CHLORIDEtlflERMAL DECOMPOSITIONjHYDROGEN CHLORIDE{RESPIRATORY EFFECTSJACUTE; PULMONARY FUNCTIONS BRITISH J OF INDUSTRIAL MEDICINE; 1990 ITEM 93 ACCESSION NUMBER 1696 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT PROGRESSION OF VINYL CHLORIDE INDUCED HEPATIC FIBROSIS TO ANGIOSARCOMA OF THE LIVER AUTHOR/AFFILIATION jones db,none;smitk pm.none; ORIGIN NONE,VOL 39 PP.306-3075 DATE 1982 ABSTRACT TWO VINYL CHLORIOE MONOMER (VCM) WORKERS, WHO DEVELOPED NON- CIRRHOTIC PORTAL FIBROSIS AND PORTAL HYPERTENSION,DIED FROM ANGIOSARCOMA OF THE LIVER FIVE AND TEN YEARS LATER RESPECTIVELY, DESPITE WITHDRAWAL FROM OCCUPATIONAL EXPOSURE. WE SUGGEST THAT NON-CIRRHOTIC PORTAL FIBROSIS CAUSED BY EXPOSURE TO VCM IS POTENTIALLY PREMALIGNANT AND THAT THOSE WORKERS WHO ALREADY HAVE THE CONDITION SHOULD BE CAREFULLY MONITORED. DESCRIPTORS ***# kumans;effects;vinyl chuorioe monomer;liver;angiosarcoma; HELD TERMS REVIEW YEAR BRITISH J OF INDUSTRIAlFME0ICINELLANDOUGH HOSPITAL (UK); 1990 -jf 20898037 'c* vO O & I > ' 1 M U f AY r Y PRINTOUT FOR 6ART JONES ORDER NUMBER 860827-135259-HIZ -001-001 PAGE 37 SET 4 NITH 365 OF 365 ITEMS itj ITEM 94 'w.- it* \ m-:- ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEM YEAR 1691 GEN PUBLICATION CARCINOGENICITY AND EPIOEMIOLOGICAfcjFROFILE ANALYSIS OF VINYL CHLORIDE AND POLYVINYL CHLORIDE KALMAZ EE.UNIVERSITY OF TEXASSKALMU GO,NONE} NONE,VOL 4 PP.13-27J .V 1984 THIS IS A VERT BAD REVIEW OF THE CARCINOGENICITY/EPIDEMIOLOGY OATA ON VCM/PVC. CONSIDERATION MAS GIVEN TO HAVING PATRICIA BUFJ&R AND MARCUS KEY DO A CRITIQUE.BUT THEIR TRIP TO CHINA PUT THIS ON HOLO IN DEFINITELY. ^ polyvinyl chloride;vinyl chloride konomer;cancer;kumans;effects;epidehiolosy; REGULATORY TOXICOLOGY ANlPHARMACOLOGY. UNIV OF TENNESSEE; 1990 & ITEM 95 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS COMMENTS REVIEM YEAR ****** ITEM 96 1690 GEN PAPER VINYL CHLORIDE EXPOSURE AND ANGIOSARCOMA OF THE LIVER-- A REPORT OF THE ICI REGISTER OF CASES doll sir richard,none; none,none; 1984 THE AUTHORS PREDICT ANOTHER 150*200 DEATHS FROM VCM RELATED ANGIOSARCOMA. THIS PROJECT IS BEING SUPPORTED BY SPI. VINYL CHLORIDE MONOMER5ANGIOSARCOMAJHUMANS;EFFECTS;EPIDEMIOLOGY; /RKHC85) DRAFT OF AN ARTICLE fm BE PUBUSHEO ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ******* REVIEM YEAR 1689 GEN PUBLICATION VINYL CHLORIOE: A CANCER CASE STUDY PURCHASE IFH,NONESSTAFFORD J.NONEiPADOLE GM.NONE; NONE.none; # 1984 jS' VINYL CHLORIOE MONOMER.CANCflf; ANGIOSARCOMA;HUMANS.EFFECTS{RISK ASSESSMENT;EPIDEMIOLOGr; 1987 m ITEM 97 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 1688 GEN JOURNAL INCIDENCE OF CANCER AMONG tNYL CHLORIOE AND POLYVINYL CHLORIDE WORKERS 20898038 ovA I'I'M rn> r'ny ir'Mr<- PRINTOUT FOR GARY JONES ORDER NUMBER 660827-135259-WIZ -001-001 PAGE 38 SET 4 WITH 385 OF 365 ITEMS t AUTHOR/AFFILIATION ORIGIN OATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR HELOAAS SS.NONEiLANGARD SLiNONE: EH A,NONE! , NONE,VOL 41 PP.25-30? 1984 THE RESULTS OF A FOLLOW UP STUD F THE INCIDENCE OF CANCER AND THE MORTALITY IN A COHORT OF 454 KALE WORKERS PRODUCING VINYL CH IDE AND POLYVINYL CHLORIDE ARE PRESENTED. THE STUDY POPULATION WAS REESTR1CTED TO EMPLOYEES Ml MORE THAN ONE YEAR'S WORK EXPERIENCE IN THE STUDY PUNT BETWEEN 1950 AND 1969 AND THE COHORT FOLLOWED UP FROM 1953 TO THE END OF 1979. TWENTY THREE NEW CASES OF CANCER MERE OBSERVED COMPA ED WITH 20-2 EXPECTEDiONE CASE OF LIVER ANGIQ5ARC0HA MAS FOUND. FIVE CASES OF LUNG CANCER WERE FOUND (2.6 EXPECTED) AND FOUR CASES OF MALIGNANT MELANOMA OF THE SKIN MERE OBSERVED (0-6 EXPECTED). THE POSSIBILITY OF A CAUSAL RELATIONSHIP BETWEEN EXPOSURE TO VINYL CHLORIDE AND THE DEVELOPMENT OF MALIGNANT MELANOMAS IS DISCUSSED. VINYL CHLORIDE MONOMER;PpLYVINYL CHLORIDE>HUMANSiEFFECTSiEPIDEMIOLOGY CANCER; BRITISH J OF INDUSTRIAL/1E0ICINE; MELANOMAS 1990 ITEM 98 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS *#*#* HELD TERMS REVIEW YEAR ITEM 99 1687 & GEN JOURNAL J VINYL CHLORIDE: THE,feVlDEHCE FOR HUMAN CARCINOGENICITY IN DIFFERENT TARGET ORGANS SALMON ag,none; A NONEVOL 42 NQ.2P9^73-745 1985, FEBRUARY VINYL CHLORIDE MONOMER J POLYVINYL CHLORIDE{ETHYLENE DICHL0RI0E;CANCER;EFFECTS;HUMANS;EPIDEMI0L0GY; BRITISH J OF INDUSTRIAL MEDICINE; 1995 / J ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS *#*** HELD TERMS KWIC INDEX NUMBER REVIEW YEAR 1645 GEN TECHNICAL REPORT VCM FROM PVC DURING THERMAL DECOMPOSITION NONE,NONE; UNION CARBIDE 1975 vcm; pvc; fragmentography; Q0713REPO 1990 ITEM 100 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN 1608 GEN TOXICITY STUDY SKIN TESTING TO TWO GEON FILMS AND ONE HYCAR PRODUCT NONE,none; BFG-BRECKSVILIE,F.M.MCDONALD (AKRON DERMATOLOGIST); 20638039 vO O I ""M ' \r,i ( PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-WIZ -OOl-OOl . PAGE 39 SET 4 WITH 585 OF 385 ITEMS X Mr; -f: i:. DATE ABSTRACT DESCRIPTORS 1971, APRIL-MAY? GEON 950X1,460X1 AFO HYCAR 2600X138 CAUSED SKIN IRRITATION IN HUMAN VOLUNTEERS. NO EVIDENCE OF SENSITIZATION NAS OBSERVED DURING THE CHALLENGE. i^ ******* GEON 460X1{ HYCAR 2600X1361 HUMAN PATCH TEST! IRRITATION'Ofjwtil)t SENSITIZATIONj HUMANSt EFFECTS; HELD TERMS GEON 950X15 - KWIC INDEX NUMBER REVIEW YEAR 00641TOXS 1990 M*- I ^ ITEM 101 ACCESSION NUMBER 1607 FILE LOCATION GEN DOCUMENT TYPE TOXICITY STUDY TITLE OR SUBJECT SKIN TESTING WITH GEON AND HYCAR PRODUCTS AUTHOR/AFFILIATION NONE,none; ORIGIN BFG-BRECKSVILLE,F.M.MC00NAL0 (AKRON DERMATOLOGIST) DATE 1972, JANUARY ABSTRACT DESCRIPTORS GEON 460X1 ANO 460X2 AND HYCAR 2600X138 PRODUCED SKIN IRRITATION IN HUMAN VOLUNTEERS. THE CHALLENGE APPLICATION FAILED TO PRODUCE ANY EVIDENCE OF SENSITIZATION. ******* humans; effects; irritation of skin; sensitization; human patch test; geon 46oxi; geon 460x2; HYCAR 2600X138; KWIC INDEX NUMBER 00640TOXS REVIEW YEAR 1990 ITEM 102 ACCESSION NUMBER 1595 FILE LOCATION GEN DOCUMENT TYPE TOXICITY STUDY TITLE OR SUBJECT HUMAN REPEATED INSULT PATCH TEST WITH GEON 130X17-RESIN AND PLASTISOL AU7H0R/AFFILIATION NONE,none; ORIGIN INDUSTRIAL BIO-TEST LABS,FOR BFG; OATE 1974, JUNE 11 ABSTRACT FOR GEON 130X17 RESIN AND PLASTISOL SOME POSITIVE SCORES HERE NOTED. IT HAS CONCLUDED THAT THESE WERE NOT SKIN IRRITANTS OR SENSITIZING AGENTS IN THESE HUHAN PATCH TESTS. DESCRIPTORS ******* GEON 130X17; POLYVINYL CHLORIDE; HUMAN PATCH TEST; SKIN IRRITATION; HUMANS; EFFECTS} SENSITIZATION; KWIC INDEX NUMBER 00626TOXS REVIEW YEAR 1995 ITEM 103 ACCESSION NUMBER FILE LOCATION "document type TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 1569 GEN PUBLICATION THE MIGRATION OF LEAD FROM POLYMERS IN THE RAT NAL TRAC6ASTR0-INTESTINAL TRACT LITCHFIELD MH,IMPERIAL CHEMICAL INDUSTRIES (ENGLAND);GAGE JC,SAME; NONE,VOL 6 PP.329-338*, 1968 THE MIGRATION OF LEAD FROM FOUR POLYMER FORMULATIONS DURING THEIR PASSAGE THROUGH THE RAT 120898040 % Q % J' f'i. PRINTOUT FOR GARY JONES ORDER NUMBER 660627-135259-UIZ -001-001 PAGE 40 SET 4 WITH 355 OF 305 ITEMS GASTRO- INTESTINAL TRACT HA BEEN INVESTIGATED. DIETS CONTAINING IX OF THE FORMULATIONS HAVE BEEN ADMINISTERED TO GROUPS OF PATS FOR 4-5 MONTHS AND MEASUREMENT'S HAVE BEEN MADE OF THE LEAD CONTENT IN BLOODtBIlE AND URINE* AND IN LIVERtKIDNEYS AM) BONE. THE GREATEST MIGRATION OF LEAD INTO THE GUT FROM THE POLYHER FORMULATIONS HAS OBSERVED WITH PVC CONTAINING E.3X LEAD SULPHATE*.WHERE THE AMOUNT HAS EQUIVALENT TO ABOUT 3 MG LEAD/G POLYMER. IT IS CONCLUDED THAT THE RISK OF LEAD POISONING FROM INGESTION OF ANY OF THE FOUR POLYMERS IS NEGLIGIBLE. DESCRIPTORS ******* DIET; CHRONICS EFFECTS* LEAO* RATS POLYVINYL CHLORIDES MIGRATIONS KMIC INDEX NUMBER 0GS92PUBL REVIEW YEAR 1990 ITEM 104 ACCESSION NUMBER 1545 FILE LOCATION GEN DOCUMENT TYPE TOXICITY STUDY TITLE OR SUBJECT SKIN TESTS WITH PLASTICIZERS ) AUTHOR/AFFILIATION NONE,NONES ORIGIN DATE ABSTRACT BFG-BRECKSVILLE.F.M.MCDONALDS 1968* FEB-MAR SAMPLES 540-89-150-'! (GEON 135 AM) GEON 264) AND 540-89-150-2 (GEON 135 AND GEON 261) AM) GE0N3 264 AND 261 DID NOT CAUSE SKIN IRRITATION OR SENSITIZATION IN A GROUP OF HUMAN VOLUNTEERS. DESCRIPTORS ******* HUMANSS EFFECTS* IRRITATION OF SKINS PATCH TESTS SENSITIZATIONS GEON I35S HELD TERMS GEON 264* GEON 261S KUIC INDEX NUMBER 00539TOXS REVIEW YEAR 1990 ITEM 105 ACCESSION NUMBER 1544 FILE LOCATION GEN OOCUMENT TYPE TOXICITY STUDY TITLE OR SUBJECT SKIN TESTING WITH POLYVINYL CHLORIDE FILM AND TO A NEW FORMULA LATEX MG) TO A RUBBER STOCK USED IN THE MANUFACTURE OF GLOVES AUTHOR/AFFILIATION NONE.NONES ORIGIN BFG-BRECKSVILLE,F.M.MCDONALD (AKRON DERMATOLOGIST) DATE 1971, JAN-FEB. ABSTRACT GEON 950X1 AND 460X1 CAUSED SKIN IRRITATION*BUT NOT SENSITIZATION* IN HUMAN VOLUNTEERS. NO IRRITATION OR SENSITIZATION WAS OBSERVED WITH FABRICS IMPREGNATED WITH THESE MATERIALS. DESCRIPTORS ******* GEON 460X1; HUMAN PATCH TEST; EFFECTS; HUMANS; IRRITATION OF SKIN; SENSITIZATION; HELD TERMS GEON 950X1; KWXC INDEX NUMBER 00537TOXS REVIEW YEAR 1990 ITEM 106 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 1540 GEN TOXICITY STUDY EFFECT OF CERTAIN POLYVINYL CHLORIDES WHEN IN CONTACT SKIN WITH THE SKIN NONE,none; 20898041 o ; mi 11 t mu r ui y !|M *C H PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-WIZ -001-001 PAGE 41 SET 4 HITH 385 OF 385 ITEMS ORIGIN BF6-BRECKSVILLEF.M.HCOONAID (AKRON DERMATOLOGIST) DATE 1966, APPIL-HAT ABSTRACT GEONS 103EPF7,120X203,202, AND 121 HERE EVALUATED IN A IRRITATION OR SENSITIZATION HAS OBSERVED. DESCRIPTORS * HUMAN PATCH TEST! EFFECTS} HUMANS} SENSITIZATION} POLT HELD TERNS GEON 103EPF7J GEON 120X203} 6E0N 202} GEON 121} KUIC INDEX NUMBER 00531T0XS REVIEW YEAR 1990 ATCH TEST. NO EYIOENCEOF l^iffilORIDEI ITEM 107 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS * HELD TERMS KWIC INDEX NUMBER REVIEW YEAR 1533 GEN COMPANY CORR FOA STATUS OF TERTIARY BUTYL PERQttY-PIVAUTE IN FOOD CONTAINER PVC RESINS KUZMA gj.none; & NONE,TO BFG-AVON LAKE} 1974, MARCH 4 =/ 1968 FDA OPINION THAT TERTIARY BUTYL PEROXY-PIVALATE (74-76X1 HITH 0.3-0.5X TERT-BUTYL HYDROPEROXIDE, 0.3X TERT-BUTYL ALCOHOL,0.IX D-TERT-BUTYL PEROXIDE, AND MINERAL SPIRITS (REMAINDER) MEETS REQUIREMENTS OF 121.2594 AND 121.2558. POLYVINYL CHLORIDESCFR176.3650} CFR178.3530} FDA ACCEPTANCE} TERTIARY BUTYL P680XY-PIVALATE} QOSIOCORR 1968 ITEM 108 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE DESCRIPTORS **##* HELO TERMS KUIC INDEX NUMBER REVIEW YEAR 1526 GEN *V' TECHNICAL REPORT EXTRACTABILITY OF ORGANOTIN STABILIZERS FROM RIGID PVC ZWICKER bmg,bfg-cheHical; BFG-CHEMICAl,TO MAT CORPJ 1962, JULY 18 i EXTRACTION TEST! ORGANOTIN STA8ILIZERS} POLYVINYL CHLORIOE} THERMOLITE-31} THERMOLITE-831? GEON 6750}JDM-2170} LS-BQ73, 00501REPO$F 1988 ITEM 109 ACCESSION NUMBER FILE LOCATION OOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 1483 GEN IH0U5TRY REPORT TEST RESULTS FOR ALCOHOLIC BEVERAGES IN OCTYLTIN STABILIZED Wc BOTTLES LARKIN MA.M A T CHEMICAL INC} MAT CHEMICAL IHC,Td INTERNAL REVENUE} 1969, OCTOBER 21 * MAT PETITION TO/OA REGARDING EXTRACTION OF DI-N-OCTYL TIN COMPOUNO FOR 21CFR121.2602 AM) oV vO o v* (ft V K"'l *- PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-WIZ -001-001 PAGE *2 SET A MITH 385 OF 385 ITEMS 121.2526(C) FOR ALCOHOLIC BEVERAGES. EXTRACTION DATA IS XNCURiEOi. DESCRIPTORS ******* POLYVINYL CHLORIDE) FDA) ORGANOTIN STABIUZERSr CFRl78,M^pi^lXiDACTX0N; KHIC INDEX NUMBER REVIEW YEAR 00436REPO 1988 't-& ff ITEH 110 ACCESSION NUMBER 1477 FILE LOCATION GEN OOCUMENT TYPE JOURNAL TITLE OR SUBJECT THE USE OF INERT PLASTIC MATERIAL IN RECONSTRUCTIVE SURGERY!PART l.A BIOLOGICAL TEST FOR TISSUE ACCEPTANCEJPART II.TISSUE S TO COWIEACTIONS TO COMMONLY USED MATERIALS AUTHOR/AFFILIATION CALNAN J,NONE 5 ORIGIN NONE,VOL 16 NO.U DATE 1963. JANUARY .{ DESCRIPTORS ******* rat; polyvinyl chloride; plastics; cancer; HELD TERMS KHIC INDEX NUMBER IMPLANTS;BRITISH J OF PLASTIC SURGERYUNIV OF LONDON; Q0429PUBL Jsf REVIEW YEAR 1990 ITEM 111 ACCESSION NUMBER 1470 FILE LOCATION GEN DOCUMENT TYPE COMPANY CORR TITLE OR SUBJECT FDA STATUS OF X-1304 AMBER JCOLOR CONCENTRATE AUTHOR/AFFILIATION BERGER RL.NONE; ORIGIN NONETO BFG-CHEMICAL; fV DATE ABSTRACT 1969, AUGUST 20 ' SUBSTANCES USED IN X-1304 AMBER COLOR CONCENTRATE HAVE FDA CLEARANCE PVC (GEON 85692 AMBER 040) BOTTLE COMPOUND. DESCRIPTORS ******* FOA ACCEPTANCE? POLYVINYL CHLORIDE} HELD TERMS CONTINENTAL CAN;GEON 85692 AMBER 0401X-1304 AMBER COLOR CONCENTRATE; KHIC INDEX NUMBER 00421CORR REVIEW YEAR 1988 ;* A MATERIAL FOR USE IN A ITEM 112 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ******* HELO TERMS KHIC INDEX NUMBER REVIEW YEAR 1463 GEN JOURNAL MORTALITY AMONG VINYL CHLORIDE WORKERS:ABSTRACT ONLY MONSON RR.NONE! none,none; 1974, AUGUST 17 POLYVINYL CHLORIDE*, CANCER, THE lancet; 00412PUBL 1990 20838043 o vs* & I nn r * ny r'lirr ;j Jl i>Ji UJ y J (I, l i llh.liil.il S66I am M3iA3a 9CCS0 d30UnN X3QNX 31MX 2(OAXOl iO AINfl) 9NIU33NI9N3 30 AllHOVd 3HI dO t 2S1S31 31V3S llVWSiSlDnOOHd 3I13HJLNAS2S13fl00dd IVti/UVN SWd3i 013H !3in3Vi3DIH`.Si33ii3!3QInHD 1ANtAA10d2N0UI0dU0330 lVWd3Hl! AlIOIXOiJNOIISnSWO:) ******* Bd01dia0S30-- 'Q31S31 SlVId31VW 31X01 1SV31 3HI JO 3N0 SVM DAd iovaisav 6161 31VQ 2t*0N St 10A`3NON Nisiao 23NON`S VSfU*aNON4X INV1IHSIX Noiivniddv/domnv siviaaiw snoiuvA JO sionoodd Nonsnaioo jo saxiioxxoi aAiiviau jo NauvmvAa mo Aanis ioarens ao aim lVNanor 3dAl 1N3WTID00 N39 N0I1V3O1 31IJ 6991 aaawrw noissboov SII M31I S66T dV3A H3IA3d 10SO aaawnN xaoNi dim* 2S1S31 31VOS 11VWS!(0A>K>1 JO AINfl) 9NIH33NI9N3 JO AiirtOVd 3HI JO r*Nie0130M3HAX09tfV3 SWd31 013H 2 33IW 23CIIXONOU N09&V3 23in0V!30Id01H3 lANIAA10d2S103JJ323dIJ2NOHISOdMOD3Q 1VWd3H12AlI3IXOl!NOIlSn9UO:) **##* Sd01dld3630 *QOOH NVH1 31X01 3dOU ON SVM 3Ad *03ia0d3a 3MV 39NVH XOI-02 3HI NX S13A31 0HO3 H1IM S9NIN0SI0d 03 JO S3SV3 NVUHH '0310N 0S1V 3dV 03 JO SN0I1VH1N33N03 SNIAdVA 01 S3SN0dS3d lVIdOAVH39 *(03X9*0 01 3dOSOdX3 3inNIH S*9) J293 SV M01 SV S13A31 9H03 HIM S1VUINV NX 031inS3d HIV30 lovaisav 1161 trON T 10A*3N0N 31V0 Hiaiao t 23NON4* INV1IHSIM NOUVIlXJJV/dOHinV 3dIJ jo a9vis iviiiHi iv siviaaivw aNicnina jo sionooad Nonsnauoo jo sanasdoaa snoxunrNi no aodis iDarans do 3im iVNanor 3dAl lH3WnaOO N39 H0I1VD01 31IJ 0S9I aaawnN noisssqsv 9IT wan S66T !OAXOl JO AINfl!A90103XX01 N0USft9H03 /jjrffiisai 31 VOS UVUSfSlOnOOdd 3X13H1NAS2SlOflOOdd lVdfUVM 23in3V2 S133JJ32 30IH01H3 1ANIAAIOd 2 N0IlIS0dM0330 1VHd3Hl2 33IN 2 A113IX012 NOIisnSHOO `Noxisnauoo jo snoiizqno3 ahi no SNiaNSdao oaxdVA aixoixoi 3hi AVW 4 9161 lZT-90T*dd I 10A43NON 23NON*X VarU4VXVN!3N0N4X XNV1IHSXX % Eionoodd N0USTI9U03 dO S3I1I3IX01 NOiivonend Vo ; U' &>; W' N39 IS9I \x+ dV3A M3IA3M SWdai 013H ******* sdoididosaa lovaisav 3iva NI9IdO Noxivniddv/doHinv xoarans do aim 3dAi lN3Wn30Q N0I1V301 31IJ daaWHN N02SS333V ill W31I ivmcs&z * EW31I S9 dO S9 H1IH 6 13S 9 39Vd 100-100- ZIM-6S2SET-129099 d3aWDN d30d0 S3N0r AdV9 dOJ lOOlNIdd PRINTOUT FOR GARY JONES OROER NUMBER 660827-135259-WIZ -001-001 PAGE 44 SET 4 HITH 385 OF 385 ITEMS . s';; ITEM 116 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS #***XW HELO TERMS KWIC INDEX NUMBER REVIEW YEAR 1448 GEN PUBLICATION PROOUCTS HOFMANN H TH,NONE!OETTEL HtSAME! NONEiNONE* 1969, OCTOBER ABS? THE TOXICITY VARIEO WITH THE CONDITIONS OF COMBUSTION. combustion;toxicity;thermal decomposition;polyvinyl chloride;rat;effects;acute; NATURAL PRODUCTS;SYNTHETIC PR00UCTS!SMALL SCALE TESTS!BASF? MODERN PLASTICS; 01519 1995 -rf > CO r(N in o pH ITEM 117 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ******* HELO TERMS KWIC INDEX NUMBER REVIEW YEAR 1447 GEN PAPER RELATIVE TOXICITY OF THERMAL DECOMPOSITION PRODUCTS OF EXPANDED POLYSTYRENE HOFMANN H TH.NONEIOETTEL H.NONE! NONE,SECOND INFORMATORY MEETING OF GERMAN BUILDING AUTHORITIES! 1967, SEPTEMBER 20 TOXIC RESPONSE VARIED WITH THE CONDITIONS OF COTBUSTION. COMBUSTION{TOXICITYJTHERMAL DECOMPOSITION,POLYVINYL CHLORIOEtRAT!EFFECTS!ACUTE! SYNTHETIC PRODUCTS*,NATURAL PRODUCTS',SMALL SCALE TESTS!BASF! 01518 1995 ITEM 113 ACCESSION NUMBER 1445 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT RELATIVE TOXICITY OF PYROLYSIS GASES FROM MATERIALS: EFFECTS OF CHEMICAL COMPOSITION AND TEST CONDITIONS AUTHOR/AFFILIATION HILADO CJ,NONE SCUMMING HJ.SAME! ORIGIN NONE,VOL 2 NO.2 PP.68-79! DATE 1978 ABSTRACT RELATIVE TOXICITY TEST OATA ON 270 MATERIALS ARE PRESENTED,BASED ON TEST PROCEDURES DEVELOPED AT THE UNIV OF SAN FRANCISCO. DESCRIPTORS **#* COMBUSTION;TOXICITY;THERMAL DECOMPOSITION5POLYVINYL CHLORIDE!EFFECTS!ACUTE!MICE! HELD TERMS REVIEW YEAR NATURAL PRODUCTSISYNTHETIC PRODUCTS!SMALL SCALE TESTS! UNIV OF SAN FRANCISCO!FIRE AND MATERIALS! 1995 ITEM 119 ACCESSION NUMBER 1444 20898045 I i U tr-l r,y i,,err >nnm UI 0t-4) o z 9p 2ro nt 9 M > CU s s SS0) H mH 3 MN m M9P<A nt E m>9< Xm am Po* <o9o Hm9 M 9M 3(0 9O (A *** Sat C--Oi 9 -->r>1 >o n-ti 0>-(0 SCHO M oM Z S--i -rhCn o9 m 2m S5 n 9 W -4 HPm- C0t_-m<"O >m --M1 oH -n mrm* -o>Mmot zo S M nn Mm mz to CO M mO mM z 22 23m*3 X*** s n mO o9 <w1111. z> nO 2 e9 oOCjl 1----M-3g -1 xM UI 9t m9 9 HHZ O X oH m O 0M3 > fOzit <a m3n -IMA- XMO-1 OCr>xMc aO nM z ni_ *H< r* -o Cml z M * o 8H 88 -4 M C-m4O r- 9 9 OznZt -A a-a O ro 9 wtWo oHH3I H> s >O14 10*>4 9C C1 l 35 rTM ii nt 9 H3 12 m 9Z m< mp- not CO mm o n9 Em< Hm93 s M 3 g CO * XX XXXX H WCO 9Hn> H a >M m o9M cn ZM c->1 z o9 N>99 >MMrMM~ -4 MHI r* m Q9 CeO 0 m n-4 OOH9 O nCin- no -3mZIDrOOCMcAo -1 J--M>1 z Z m9 OZ C2 m9 M o swo Z > Hc9 > 99 3 (A ui na 303 cco MH o --HOZ xM -Hn1I > 9m n9 >m -4 m >CM9D nCA HM3nt --1 x z 9 O9 zmoZ-< 9 9HI n Cl m zm9> rr-"~< HI Zo9m> Cn0A E 9 > 09 MnUi M Z --zm1 O r>wrt o MZ m u>s 3P9" m (A no Z H(AI (HmOA M o CXMHIl -H< CnA 9m m ZHI nHt < H>9 s CA Cm>29PA* CO o*n 9 H> Z Z S-<s0oi OZm- Mp>a- >uo<rno 9M 1- 0 99 -2 32m wM 0 WMM1 9>Cm 0>n n o* H4i 0z s s -< fMit tO_ C9 rZ>- Om Z MA' MA UI M 9 CA m9g *n *On HO9 o- 3M 9> h mn ZO)*|lli w m 2 Hro o 9X0 o o > --10 9 m <m m X -m< >9 m Cb fMit 92 CO hi Sn2 9 M9 HO 9CO X*X X3XX t0o h9> Hn PH m 9M ci MZ C-1 z O9 9s>9Mt-- H --M4 g M--i OnMp- rm* c 3 m m r- S3S ICM-< 4>M m Cl H H 2 ft -00>-1O3 Vtgg > (A r Mm 99 QZ Sh gs MM (A OHI C-CO -M< z * 9 <n HyMO* Z O z Z M r- ZOCns>Dt H9H9r"N-991 <aan2 om $1 m m QC32J M 9 m r* -i m <m H XMO nM o9 0IHn-I > HH S z 3 29 32 S-S S 9> 0m 0fit 9_2_ AS ut 3 S9 Wm 99o --^ 9r* CM ga X Mtit 3 W ME MZ O9 HMO .5Jstf ^ 3 MiS g2W hOl cf9ri 9 < 9 iO 9 im i CO fit oh x ca?o*?m^a2gE "3 0 6) s 3" > 35 HI 3O S2 22 ZSSS S9 <A 9 iH 1! s -- CA 9 CA M M 3> MM r- 4 M9 pm f O (A - IA 31 imsl >3P mo mo udcp MZ 9 h Io- >n a r> n u> muni oxn M9 OB O9 S5 >lOQM(A n nt x > -4 CB 2I2>9 Z0 ~0 -14-1 m 3 n Ja K m m Hx m HO-3 o Zt) o s*s MOUJ ss> ?5>l ?s 5 5 m 35 nt a *< <_ o9 a0 m zM 133 H 9 (A 3m to Si5 c* 155 *_2SS XW >OJ M *5$ m 25 8 PRINTOUT FOR GARY JONES ORDER NUMBER 660827-135259-HIZ -001-001 PAGE 46 SET 4 WITH 365 OF 365 ITEMS - ??&! FILE LOCATION GEN ? ` OOCUMENT TYPE PAPER , TITLE OR SUBJECT RELATIVE TOXICITY OF THE PYROLYSIS PROOUCTS FROM SOME THERMOPLASTIC AND THERMOSET POLYMERS AUTHOR/AFFILIATION ORIGIN HIUDO CJN0NE;CUMMIN6 HJ.5AMEIKOURTI0ES DA.NONEISILHEE HJjfUNONE! SOCIETY OF PLASTICS ENGINEERS^REGIONAL TECHNlCAtjCONFEREHKfS^MRTICUT SECTION; f DATE ABSTRACT 1977 ; RELATIVE TOXICITY DATA ON THE PYROLYSIS PROOUCTS OF A VARIETY bF THERMOPLASTIC AND THERMOSET POLYMERS ARE PRESENTED. THE OATA ARE PRESENTED IN TERMS OF TIME TO INCAPACITATION AND TIME TO DEATH WITH A FIXED SAMPLE WEIGHT OF 1.0 G, AND IN TERMS OF THE APPARENT LETHAL CONCENTRATION REUIRED TO PROOUCE SO* MORTALITY WITHIN A FIXED EXPOSURE PERIOO OF 30 MIN. *******DESCRIPTORS combustion;toxicity;polyvinyl chloride{thermal oecqmposition;mice;effects;acute; HELD TERMS UNIV OF SAN FRANCISCO;NASA AMES RESEARCH CENTER{SYNTHETIC PRODUCTS! SMALL SCALE TESTS! REVIEW YEAR 1995 ITEM 123 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS *#**# HELD TERMS REVIEW YEAR 1436 GEN JOURNAL CONCENTRATION-TIME DATA IN TOXICITY TESTS AW RESULTING RELATIONSHIPS HILAOO CJ,NONE!BRAUER dp,same; J OF COMBUSTION TOXICOLOGY,VOL 6 PP.1365-149! 1979, MAY NUMERICALLY,PVC HAS LESS TOXIC THAN HOOD. combustion;toxicxty;thermal decomposition {effects;acute;mice;polyvinyl chloride; NATURAL PROOUCTS{SYNTHETIC PROOUCTS{SMALL SCALE TESTS!UNIV OF SAN FRANCISCOS 1995 ITEM 124 ACCESSION NUMBER 1435 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT SCREENING MATERIALS FOR RELATIVE TOXICITY IN FIRE SITUATIONS AUTHOR/AF FILIATION HILAOO CJ,NONE{ ORIGIN NONE,PP.64-665 DATE 1977, JULY ABSTRACT RESULTS OF SCREENING TESTS OF MATERIALS FOR RELATIVE TOXICITY UNDER SPECIFIC SETS OF CONDITIONS ARE PRESENTED. VARIATIONS IN THE MATERIAL, IN LAB ANIMALS, AM) IN THE TEST PRESENTLY PERMIT IDENTIFICATION OF MAJOR RATHER THAN MINOR DIFFERENCES AMONG MATERIALS. CORRELATION WITH RELATIVE PERFORMANCE IN REAL FIRE SITUATIONS IS BASED ON A LIMITED NUMBER OF COMPARISONS. NUMERICALLY,PVC WAS LESS TOXIC THAN MANY MOODS. DESCRIPTORS ******** COMBUSTION{TOXXCITY{THERMAL DECOMPOSITION{POLYVINYL CHLORIDE{EFFECTS;ACUTE; MICE! HELD TERMS SYNTHETIC PROOUCTS{NATURAL PRODUCTS;SMALL SCALE TESTSiMODERN PLASTICS! REVIEW YEAR 1995 ITEM 125 ACCESSION NUMBER FILE LOCATION 1434 GEN 20838047 BFG52736 I i m m mu | r nr* r*pv PRINTOUT FOR 6ARY JONES ORDER NUMBER 860827-135259-WIZ 001-001 PAGE 47 SET 4 WITH 385 OF 385 ITEMS DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR JOURNAL A COMPARATIVE REVIEW OF THE COMBUSTION TY OF POLYVINYLCHLORIDE HINDERER RKBF GOODRICH C0J ~ NOME,VOL 2 PP.62-97, 7 1984, JANUAHY-FEBRUARY ,, ........... , IN CONCLUSION,ALL OF THE COMBUSTIQ^TOXICXTY STUDIES DESCRIBED ABOVE SHOW THAT THE RELATIVE TOXICITY OF A MATERIAL CAN VARY DEPENDING ON MANY FACTORS SUCH, AS THE TEMPERATURE OF DECOMPOSITION, THE METHOD OF DECOMPOSITION, THE AIR FLOW, THE HUMIDITY THE ANIMAL SPECIES, THE ENVIRONMENTAL TEMPERATURE, THE'DEGREE OF OXYGEN DEPLETION, AND THE TREATMENT OF THE DATA. STILL, THE FACT REMAINS THAT NUMEROUS,INVESTIGATORS FROM ACADEMIA,GOVERNMENT, AND THE PRIVATE SECTOR HAVE FOUND NO EVIDENCE THATBTC ZS EXTREMELY OR UNUSUALLY TOXIC RELATIVE TO NATURAL PRODUCTS. WHILE SOME TEST METHODS INDICATED THAT PVC IS MORE TOXIC THAN CERTAIN NATURAL PRODUCTS, MOST STUDIES HAVE SHOWN THAT THJf COMBUSTION TOXICITY OF PVC IS LESS THAN, OR COMPARABLE WITH THAT OF NATURAL PRODUCTS. CONSIDERING THAT URGE AMOUNTS OF COMBUSTIBLES IN HOMES AND THAT MULTI-STORY BUILOINGS ARE A FACT QF/UFE, THE DATA DOES NOT SUPPORT CONTENTIONS THAT PVC IS UNUSUALLY TOXIC OR HAZARDOUS. // COMBUSTION;TOXICITYjYHERMAL DECOMPOSITIONiPOLYVINYL CHLORIDEEFFECTS{ACUTE; SMALL SCALE TESTS;j"tF FIRE SCIENCES; 1995 ITEM 126 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ****# HELD TERMS REVIEW YEAR 1433 GEN PUBLICATION ,3* TOXIC HAZARDS FROM COMMON MATERIALS hiuoo cj,none;huttujer pa,same; NONEPP.177-101; 1981 NUMERICALLY PVC HAS LESS TOXIC THAN MOOD. COMBUSTION>TOXICITYTHERMAL DECOMPOSITIONJPOLTVINYL CHLORIDEEFFECTSACUTE; MICE; SMALL SCALE TESTS5NATURAL PROOUCTS;SYNTHETIC PRODUCTS;PRODUCT SAFETY COPPSFIRE TECHNOLOGY; 1995 f ITEM 127 ACCESSION NUMBER 1432 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT BIOLOGICAL EVALUATION OF THE TOXICITY OF 6ASES PRODUCED UNDER FIRE CONDITIONS BY SYNTHETIC MATERIALS. PART 2i BEHAVIOUR OF SYNTHETIC MATERIALS IN OEFINITE COMBUSTION CONDITIONS AS COMPARED TO THE BEHAVIOUR OF TRADITIONAL MATERIALS IN SAME CONDITIONS AUTHOR/AF FILIATION HERPOL C.NONEiMINNE R.SMIEi ORIGIN NONE,VOL 12 PP.229-244; DATE 1976 ABSTRACT THE AUTHORS COMPARED THE COMBUSTION TOXICITY OF A NUMBER OF NATURAL AND SYNTHETIC MATERIALS UNDER A NUMBER OF CONDITIONS. DEPENDING ON THE CONDITIONS,PVC WAS LESS TOXIC OR MORE TOXIC THAN WOOD. DESCRIPTORS *### combustion;toxicity;thermal decomposition;polyvinyl chloride;mooo;pustics;rat; effectsjacute HELO TERMS SMALL SCALE TESTSJNATURAL PRODUCTS;COMBUSTION SCIENCE AND TECHNOLOGY;STATE UNIV OF *0 5 X 1 3 1 cn f* l PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-WIZ >001-001 PAGE 48 SET 4 WITH 385 OF 385 ITEKS REVIEW YEAR GHENT(BELGIUH); 1995 j? ITEM 128 ACCESSION NUMBER 1431 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT REPORT THE PHYSIOLOGICAL AND TOXICOLOGICAL ASPECTS OF DEGRADATION PRODUCTS PRODUCED DURING THE COMBUSTION OF POLYVINYL CHLORIDE POLYMERS AUTHOR/AFFILIATION EINHORN IN,UNIVERSITY OF UTAHJGRUNNET ML,SAME; ORIGIN NONE,SPECIAL REPORT EL-1263; DATE 1980 ABSTRACT THE AUTHOR REVIEWS A NUMBER OF FIRES NHERE PVC MAS INVOLVED,THE THERMAL DECOMPOSITION OF PVC, ANO COMBUSTION TOXICITY EVALUATIONS OF PVC (INCLUDING DETAILED OBSERVATION,BLOOD PH DETERMINATIONS, AND PATHOLOGY). DESCRIPTORS *##** combustion;toxicity;thermal decomposition;effects;polyvinyl chloride;acute;rat; fire HELD TERMS SMALL SCALE TESTS;ELECTRIC POWER RESEARCH INSTITUTE) REVIEW YEAR 1995 ITEM 129 ACCESSION NUMBER 1430 FILE LOCATION GEH DOCUMENT TYPE JOURNAL TITLE OR SUBJECT METHODOLOGY FOR THE STUDY OF TOXICOLOGY IN COMBUSTION APPLICATION TO PVC AUTHOR/AFFI HATION EINHORN IN,UNIVERSITY OF UTAH) ORIGIN NONE,All VOL 8 PP.1519-1528) DATE 1977 ABSTRACT THE AUTHOR DISCUSSES A NUMBER OF POINTS INCLUDING OELAVED NEUROPATHY-REUTED DEATHS FROM CO, OTHER FACTORS SUCH AS ALCOHOL WHICH AFFECT THE TOXICITY OF CO,IRRITANTS PRODUCED BY UCXIO AT DIFFERENT TEMPERATURES, AND THE COMBUSTION TOXICITY OF PVC. DESCRIPTORS **##* combustion;toxicity;thermal decompositionjpolyvinyl chlorioeEffects,acute;rat; woooiACRoiEiN* aldehydes;carbon monoxide; HELD TERMS IRRITANTS;SMALL SCALE TESTS) J MACROMOL SCI-CHEM) REVIEW YEAR 1995 ITEM 130 ACCESSION NUMBER 1429 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT RELATIVE TOXICITY OF PYROLYSIS PRODUCTS FROM SOME UPHOLSTERY FABRICS AUTHOR/AFFILIATION HILADO CJ,NONES LOPEZ MT,NONESDAMANT 6H,N0NE; ORIGIN NONE,VOL 6 PP. 155-175; DATE 1977, JANUARY ABSTRACT TWENTY-TWO SAMPLES OF UPHOLSTERY FABRICS USED IN HOME FURNISHINGS WERE EVALUATED FOR RELATIVE TOXICITY BY MEANS OF THE USF/NASA TOXICITY SCREENING TEST. DESCRIPTORS #**#* combustion;toxicity;thermal decohpositiompolyvinyl chlorxoe;effects;acute;hxce; HELD TERMS SYNTHETIC PRODUCTS;NATURAL PRODUCTSJSMALL SCALE TESTS;UNIV OF SAN FRANCISCO;STATE OF CALIFORNIA; 20898049 V* 3 F G 5 2 '7 3 8 iirf'Mr rfin TAny PRINTOUT FOR GARY JONES OROER NUMBER 660827-135259-WIZ -OOl-OOl , PAGE 49 SET 4 WITH 365 OF 365 ITEMS REVIEW YEAR J COATED FABRICS; 1995 ITEM 131 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** HELD TERMS REVIEW YEAR 1427 rf GEN PAPER MATERIALS TOXICOLOGY EVALUATION BY DIRECT ANIMAL EXPOSURE SMITH PM.NONEiCRANE CR>NONE{SANDERS DNONEjABBOTT J,NONE? ENDECOTT B>NONE UNIVERSITY OF UTAH,INTERNATIONAL SYMPOSIUM ON TOXICITY AND WYSIOLOGY OF COTeUSTION PRODUCTS; 1976, MARCH 22-26 THE AUTHORS REPORT THE COMBUSTION TOXICITY OF NUMEROUS NATURAL AND SYNTHETIC MATERIALS. combustion;toxicity;thermal decomposition,effects;rat;acute;polyvinyl chloride; plastics; FAAJDEPT OF TRANSPORTATION}DOT;SMALL SCALE TESTSSNATURAL PRODUCTS; 1995 ITEM 132 ACCESSION NUMBER 1398 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT EXPERIMENTAL TOXICOLOGY OF PYROLYSIS AND COMBUSTION HAZARDS AUTHOR/AF FILIATION CORNISH HH,UNIVERSITY OF MICHIGAN!HAHN KJ,SAME{BARTH ML.SAMEt ORIGIN ENVIRONMENTAL HEALTH PERSPECTIVES,VOL 11 PP.191-196; DATE 1975 ABSTRACT UNDER STATIC C0NDITI0N5PVC WAS NIA1ERICALLY THE LEAST TOXIC MATERIAL TESTED ,AN> WHILE UNDER DYNAMIC CONDITIONS IT RANKED NEAR THE MIDDLE. DESCRIPTORS ****# combustion;toxicity;polyvinyl chlopide;plastics;thermal decohpositionjrat; effects;acute; HELO TERMS NATURAL PROOUCTS;SMALL SCALE TESTS; REVIEW YEAR 1995 ITEM 133 ACCESSION NUMBER 1397 FILE LOCATION GEN DOCUMENT TYPE SYMPOSIUM TITLE OR SUBJECT TOXICITY OF THERMAL-DEGRADATION PRODUCTS OF PLASTICS AUTHOR/AFFILIATION CORNISH H,UNIVERSITY OF MICHIGAN; ORIGIN NONE,SYMPOSIUM FOR PRODUCTS OF COMBUSTION OF BUILDING MATERIALS; DATE 1973 ABSTRACT UNDER STATIC CONDITION PVC HAS (NUMERICALLY! THE LEAST TOXIC MATERIAL TESTED,BUT WHILE UNDER DYNAMIC CONDITIONS IT RANKED NEAR THE MIDDLE. DESCRIPTORS ******* combustioh;toxicity;thermal decomposition;rat;effects;acute; polyvinyl chlorioe;plastics; HELD TERMS SMALL SCALE TESTSJNATURAL PRODUCTS; REVIEW YEAR 1995 ITEM 134 ACCESSION NUMBER 1396 11 ' r'v i; r * nv '("'it 20^.?RO"t BFG52740 PRINTOUT FOR GARY JONES ORDER NUMBER 860827 '135259-HIZ -001-001 PAGE 50 SET 4 WITH 365 OF 385 ITEMS S8 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT TOXICITY OF PYROLYSIS PRODUCTS OF VINYL PLASTICS AUTHOR/AFFILIATION CORNISH hhnone;abar el,none; vW- ORIGIN ARCHIVES OF ENVIRONMENTAL HEAtTH.VOt 19 PP.15-21? DATE 1969, JULY * ABSTRACT POLYVINYL CHLORIDE POLYMERS AND FORMULATIONS HERE PYROLYZED IN A STREAM OF AIR BY GRADUALLY RAISING THE TEMPERATURE FROM AMBIENT TO APPROXIMATELY 600 C. THE PYROLYSIS AIR STREAM HAS OILUTED HITH THICE ITS VOLUME OF ROOM AIR, AND RATS HERE EXPOSED TO IT. MOST DEATHS WERE DUE TO CARBON MONOXIDE CCO), AND CARBOXYHEMOGLOBIN (COHB) LEVELS CORRELATED HELL HITH THE AMOUNT OF PLASTIC PYROLYZED. LITTLE HISTOLOGICAL EVIDENCE OF LUNG DAMAGE HAS EVIDENT. NHEN OXYGEN (021 HAS ADDED TO THE AIR STREAM TO PREVENT DEATHS FROM CO,PULMONARY EDEMA AND INTERSTITIAL HEMORRHAGE DEVELOPED. THE LUNGS OF SOME ANIMALS EXPOSED TO HIGH LEVELS OF PYROLYSIS PRODUCTS OF VINYL CHLORIDE-VINYL ACETATE COPOLYMER ALSO SHOUED FOCAL EDEMA AND INTRA-ALVEOLAR HEMORRHAGE. POLYVINYL CHLORIDE FORMULATIONS, CONTAINING ADDITIVES AND INERT MATERIALS, HERE IN GENERAL LESS TOXIC PER GRAM OF SAMPLE PYROLYZED. DESCRIPTORS #**** COMBUSTION5TOXICITY{THERMAL DECOMPOSITION;POLYVINYL CHLORIDE?RAT?EFFECTS?ACUTE? HELO TERMS SMALL SCALE TESTS; REVIEW YEAR 1992 ITEM 135 ACCESSION NUMBER 1395 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT PROTECTIVE EFFECT OF NATER AGAINST TOXICITY OF PYROLYSIS AND COtCUSTION PRODUCTS OF HOOD AND POLY(VINYL CHLORIOE) AUTHOR/AFFILIATION BOUDENE C,N0NE 5JOUANY JM.NONEJTRUHAUT R,NONE5 ORIGIN NONE,All NO.6 PP.1529-1545? DATE 1977 ABSTRACT WATER PROTECTED AGAINST FUMES FROM BOTH PVC (HCL AND PARTICULATE I AND HOOD (ALDEHYDES AND PARTICULATE). CO HAS NOT TRAPPED. DESCRIPTORS **#** COMBUSTION;TOXICITY5RABBIT;POLYVINYL CHLORIDE?THERMAL DECOMPOSITION;EFFECTS!ACUTE? HELO TERMS SMALL SCALE TESTS.J KACROMOL SCI-CHEM;LABORATORY OF TOXICOLOGY (FRANCE); COMMENTS REVIEW YEAR RKHI85) BASEO ON THE CONCLUSIONS,THE COLUTWS "WITH HATER" AND 'WITHOUT HATER" HERE TRANSPOSED 1995 ITEM 136 ACCESSION NUMBER FILE LOCATION OOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AF FILIATION ORIGIN DATE ABSTRACT 1393 GEN PUBLICATION SMOKE AND TOXICITY HAZARDS OF PLASTICS IN FIRE BOWES pc,none; ANNALS OF OCCUPATIONAL HYGIENE,VOL 17 PP.143-147? 1974 AMONG FATAL AND NON-FATAL CASUALTIES IN FIRES IN BUILDINGS, THE ANNUAL PROPORTION DUE TO SMOKE ANO TOXIC GAS HAS INCREASED THREEFOLD OVER A PERIOD OF SEVENTEEN YEARSiOVER HALF THE TOTAL FATALITIES IN FIRES ARE NOT DUE TO THIS CAUSE. THIS PAPER BRIEFLY REVIEWS THE PROBLEM OF SMOKE AND TOXIC GASES IN FIRES AND DESCRIBES INVESTIGATIONS AIMED AT DETERMINING WHETHER THE 20998051 t r "! i r rnn r v 1'i'irr, PRINTOUT FOR GARY JONES ORDER NUMBER 560027-135259-WIZ -001-001 , PAGE 51 SET 4 WITH 305 OF 565 ITEMS -*V DESCRIPTORS COMMENTS REVIEW YEAR INTRODUCTION OF NON-TRADITIONAL MATERIALS, PRINCIPALLY PLASTICS,INTO BUILDINGS IS LIKELY TO HAKE A SIGNIFICANT INCREASE IN THE NUMBERS OF FIRE CASUALTIES INVESTIGATIONS COVERED THE PYROLYSIS OF PLASTICS UNDER TESTS IN WHICH THE GENERATION AND SURVIVAL OF SIGNIFICANT MEASUREMENTS OF THE TOXICITY OF FIRE GASES.RESULTS ARC 6 BY GAS OR SMOKE. THE CONDITIONS,LARGE-SCALE FIRE ucTs mere MONrrnttr ahd ' IGIO PVC USED AS UALLLININBS AND FOR FLEXIBLE POLYURETHANE FOAM BURNING IN BULK. IT OF THESE MATERIALS CAN PRODUCE:AN UNACCEPTABLE HAZARD, That large industrial fire loads NORK IS NEEDEO BEFORE CONCLUSIONS CAN BE REACHED FOR FIRE LOAOS RELEVANT TO,FOR EXAMPLE,PRIVATE DWELLINGS. #MM M M M iifpnn<wiY COMBUSTIONiTOXICITYPOLYVINYL CHLORIOEJFIREjTHERMAL DECOMPOSITION? OPTICAL 0ENSITY) RKH(65) FIG.7 SHOWS THAT THE OPTICAL DENSITY WITH MOOD (1E7K6) IS HIGHER THAN FOR MOOD AND PVC (127 AW 100 KG) COMBINED. 1995 ITEM 137 ACCESSION NUMBER 1390 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT SENSORY IRRITATION EVOKEO BY THE THERMAL DECOMPOSITION PROOUCTS OF PLASTICIZED POLY(VXNYL CHLORIDE) AUTHOR/AFFILIATION BARROW CS,UNIVERSITY OF PITTSBURGH{ALARIE Y,SAME{STOCK HFSAHE? ORIGIN NONE,VOL 1 PP.147-1535 OATE 1976 ABSTRACT THE AUTHORS PREOICT THAT THE RD50 FOR PVC AND OTHER COMPOUNDS WILL BE RAPIDLY INCAPACITATING. STUOIES BY POTTS AW LEDERER AND BY FAA (STUDIES WITH BABOONS AT SOUTHWEST RESEARCH INSTITUTE/KAPLAN ET AL 1964) HAVE SHOWN THAT THIS PREDICTION IS UNFOUNDED. DESCRIPTORS ******* COMBUSTION;TOXICITY)PLASTICS?POLYVINYL CHLORIDE{HYDROGEN CHLORXOE{EFFECTS;ACUTE{MICE; THERMAL decomposition; HELD TERMS FIRE AND MATERIALS;SNALL SCALE TESTS; KWIC INDEX NUMBER 01669 REVIEW YEAR 1995 ITEM 138 ACCESSION NUMBER 1389 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT A COMPARISON OF THE ACUTE INHALATION TOXICITY OF HYDROGEN CHLORIDE VERSUS THE THERMAL DECOMPOSITION PRODUCTS OF POLYVINYLCHLORIDE AUTHOR/AFFILIATION BARROW CS,UNIVERSITY OF PITTSBURGH;LUCIA H,SAME{ALARIE YCtSAMEt ORIGIN J OF COMBUSTION TOXICOLOGY,VOL 6 PP.3-12) DATE 1979, FEBRUARY ABSTRACT THE AUTHORS CONCLUDE THAT HCL APPEARS TO BE THE PRINCIPLE CONTRIBUTOR TO THE TOXICITY OF PVC. THIS,HOWEVER, ZS MORE THE RESULT OF THE UNIV OF PITTSBURGH TEST OESIGNSIT WAS SPECIFICALLY DESIGNED TO MINIMIZE THE EFFECT OF CO AND WAS INTENDED FOR STUDIES OF IRRITANT GASES.BECAUSE OF THE CHAMBER SIZE,FLOW RATE AND METHOD OF COMBUSTION, CO IS BLOWN THROUGH THE CHAMBER AM) IS NEVER ALLOWED TO ACCUMULATE. THE REAL QUESTION IS WHETHER THIS TEST SYSTEM HAS ANY RESULT OF THE UNIV OF PITTSBURGH'S TEST DESIGN.IT WAS SPECIFICALLY RELEVANCE TO REAL WORLD FIRES. DESCRIPTORS ******* COMBUSTION;TOXIClTY;POLYVINYL CHLORXOEJTHERMAL DECOMPOSITION)EFFECTS{ACUTESMICE{ HELO TERMS SMALL SCALE TESTS; 20898052 ^' O K .f i '' 1' < I i r M f I'M r/>py mt PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-WIZ -001-001 PAGE 52 SET A HXTH 365 OF 385 ITEMS REVIEW YEAR 1995 .* ITEM 139 % ACCESSION NUMBER 1388 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT JOURNAL ;, DEVELOPMENT OF METHODOLOGIES TO ASSESS THE RELATIVE HAZARDS FROM THERMAL DECOMPOSITION PRODUCTS OF POLYMERIC MATERIALS AUTHOR/AFFILIATION ORIGIN BARROW CS,UNIVERSITY OF PITTSBURGH5LUCIA H,SAME{STOCK HF,SAME1 ALARIE Y.SAMEi AMERICAN INDUSTRIAL HYGIENE ASSOCIATION,VOL AO PP.408-4Z3J OATE ABSTRACT 1979, MAY THE PHYSIOLOGICAL STRESS IMPOSED UPON MICE DUE TO THE IRRITATING PROPERTIES OF THERMAL DECOMPOSITION PRODUCTS OF POLYMERIC MATERIALS WAS EVALUATED. ACUTE LETHALITY AND HISTOPATHOLOGICAL EVALUATIONS MERE INCLUDED IN THE STUOY. THE RANKINGS OF THE POLYHERIC MATERIALS STUDIED FROM MOST TO LEAST HAZARDOUS MAS CONCLUDED TO BE POLYTETRAFLUOROETHYLENE,POLYVINYL CHLORIDE,DOUGLAS FIR, AND POLYTETRAFLUOROETHYLENE,POLYVINYL CHLORIDEDOUGLAS FIR AND -(FLEXIBLE POLYURETHANE FOAM,FIBER GLASS REINFORCED POLYESTER, COPPER COATEO MIRE WITH MINERAL INSULATION. DESCRIPTORS #****# polyvinyl chloride;combustion;toxicity;plastics;effects;acute;mice;thernal decomposition; HELD TERMS NATURAL PRODUCTSJSMALL SCALE TESTS? KWIC INDEX NUMBER 04655 COMMENTS RKH(85) PATHOLOGY EVALUATIONS OF UPPER RESPIRATORY TRACT SHOWS OAMAGE FROM DOTH PVC-A AND DOUGLAS FIR.SOMEWHAT HIGHER SCORES AT LOWER OOSES HAS OBSERVED WITH PVC-A. REVIEW YEAR 1995 ITEM 140 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 1387 GEN PUBLICATION SENSORY IRRITATION AND INCAPACITATION EVOKED BY THERMAL DECOMPOSITION PROOUCTS OF POLYMERS AND COMPARISONS WITH KNOWN SENSORY IRRITANTS BARROW CS,UNIVERSITY OF PITTSBURGHiALARIE Y,SAME{STOCK MF.SAME? ARCHIVES OF ENVIRONMENTAL HEALTH,VOL 33 PP.79-88; 1978, MARCH/APRIL A DECREASE IN RESPIRATORY RATE IN MICE DURING EXPOSURE TO IRRITATING AIRBORNE CHEMICALS HAS BEEN UTILIZED AS A RESPONSE PARAMETER TO CHARACTERIZE THE DEGREE OF UPPER RESPIRATORY TRACT IRRITATION (SENSORY IRRITATION) TO THE THERMAL DECOMPOSITION PROOUCTS OF VARIOUS POLYMERS. THESE INCLUDED POLYSTYRENE, POLYVINYL CHLORIDE,FLEXIBLE POLYURETHANE FOAM,POLYTETRAFLUOR- ETHYLENE, A FIBER GLASS REINFORCED POLYESTER RESIN, AND DOUGLAS FIR. EACH OF THE MATERIALS WAS THERMALLY DECOMPOSED IN A LOW-MASS VERTICAL FURNACE IN AN AIR ATMOSPHERE AT A PROGRAMMED HEATING RATE OF 20DDEGREES C/MIN. MICE, IN GROUPS OF FOUR, HERE EXPOSEO TO GRADED CONCENTRATIONS OF THE THERMAL DECOMPOSITION PROOUCTS OF EACH OF THE ABOVE MATERIALS. DOSE-RESPONSE CURVES HERE OBTAINED BY UTILIZING THE MAXIMUM PERCENT DECREASE IN RESPIRATORY RATE AS THE RESPONSE PARAMETER DURING EACH EXPOSURE. COMPARISON OF THESE DOSE-RESPONSE CURVES HXTH OTHER SENSORY IRRITANTS SUCH AS CHLORINE, AMMONIA,HYOROGEN CHLORIDE,SULFUR DIOXIDE,AND TOLUENE DIISOCYANATE GAVE AN INDICATION OF THE SENSORY IRRITATION POTENTIAL OF THE THERMAL DECOMPOSITION PROOUCTS OF THESE VARIOUS POLYMERS VERSUS THAT OF WELL-KNOWN SINGLE AIRBORNE CHEMICAL IRRITANTS.TOTAL STRESS AND INCAPACITATION OF THE ORGANISM DURING EXPOSURE TO SENSORY IRRITANTS SUCH AS FROM THE THERMAL DECOMPOSITION PROOUCTS OF SYNTHETIC POLYMERS IS DISCUSSED. ! -^ >\ 20898053 vn i I i"MHMMir rnp r^r?Y U J. ||I| All V J Nil I I ... 1 A y"''* o ' O' _a % most isxsax aivos nvwsisionaoad ivanivN swaax oi3H lN0IUS0dU033Q 1VUU3HL i33IH!3in3Vi8133333f3012(01H3 lANIAAIOdiSOIASVId1AU3IX0A iNOUSnOWOO **** saoidiaosao ..sawn aunsodxa iNaaaddia hum 39nvho him aaaao xnv shi.. ivhi aaioN osiv si n *1/9 nvhx adHiva suvaa no ogsva osoi jo sivnoiavu ssnosia osiv asha ..3on3oijno3 hum siviaaxvw NaaMias usinaNiisia oi., ax do saoxovd as siviaaxvu SNidnoas xaoddns saoHinv ani XOVdiSOV Advnnvr *0x61 31VQ fsaavoNVis do nvdano ivnoiivn Oi'Hsanosiiid do AxisuaAiNn NI9IB0 ianvsrA diaviviHsanosiiid do AiisaaAiNn'a Nosaaonv NOIAVIlIddV/dOHinV SS3BAS 1VUB3HX tiaONTI siviaaxvu oidauAiod MOdd sxonooad Nouisoduoaaa ..aixoxaadns.. aziNSOoaa 01 aanaaooad SNiNdaaos ioarens ao 31m laodaa 3dAl INdUflOOG N39 N0IXV301 3113 S0T aasunn noiss30ov 3VT M3AI S66X JSAS3A 31V3S 11VHS1NOIiVilMdl ABOSN3S S33iuiairov 1SA33JJ3!BOIiSVIdlN0IAIS0dM033a 1VUa3HUAiI3IX0i!N0XiSnSU03!3GIU01H3 lANIAAIOd SHivaa on qnv 4ssaaxs ao Noixvuaai on asowiv a3snvo`SNiiV3H oNiana A1MQ1S AB3A 03603110330 BOINVADOdddd 3NIZ`J13SiI AO 'daiNVADOdddd 3NI2 dO NOIUOQV H1IM 39HVH3 AON Old 3AVN0SBV3A10d dO AlIlVHiai SADOV 3Hi `H3A3M0H *3N3BdOa01H3A10d ONV aQIM01H31ANIAA10d *Sd3UA*IOd 9NXiVa3N39-3Qia01H3 3014101 HO N39QB0AH (XU 3HX HOd 03300341 SVM S1VWINV 3Hi dO xos do hav3Q asnvo ox odainoda 1H9I3M aidvivs aHi *3AVNoaav3Aiod ni aaiNVADoaaad oniz jo aoNasaud 3Hi AO G3N3SS31 SVM NOIiVXIBdl AB0SN3S *03AVmVAa 0NI30 AXI3IX0A JO X3QNI 3Hi ONV diUAIOd 3HA NO 9NIGN3d3Q4i33JJ3 31SVIBVA V OVH 3aiNVA30dadd 3NI2 dO NOIIIOOV 3HA ** JO B0X3VJ V AS SB3UA10d OMi ddHAO 3Hi JO AVHA NVHA M3H9IH SVM 3NaadOdO1H3A10d tiOd AU1VHL31 3AHOY 3H1 'SiOnOOdd NOIlISOdHOOdQ 3AVNOQBV3A1Od HAIM 03AVX30SSV 3B3M SSdtLLS ONV NOIiVildUI 1SV31 3Hi *30ia01H31ANIAA1Dd UOBJ 3S0H1 3H3M SiOflOOdd SlSAIOBAd IflJSSdiiAS ISOM 3Hi ONV 9NIiVAIBtfX XSON 3Hi *3GINVA30aa3J 3NIZ XS 9NINIVXN03 H3HA10d 3WVS 3Hi HAIM 03iSVHiN03 N33S SVH B3NA10d H3V3 *AiI1VH131 ainov qnv `NoiionoNi ssaais iV3i90ioisAHd4NoixvxiBBi abosnss boj aaxsax aa3M aiVNoaavoAiod QNV43N3adOa01H3A10d43GiaOiH31ANIAA1Od 4SH3UA10d 33dHi JO SiOflOOBd NOIilSOdMOOSO IVUddHA *Q3d013Ada N33Q 3AVH K3IHM AXI3IX0X JO S33I0NI 3Hi JO 33NVMB0JB3d 3Hi 3XVmVA3 OX U30BO NI 0X61 10A`3N0H 13WVS4A 3IBV1V !3HVS4B NIffVSl3UVS4H XVriiVH 13HVS*JH X30iS23UVS4r JBOOBdiaiHSdnSSXUd JO AiISd3AINn`Da N0SB30NY SSddiS 1VMH3Hi d3(M1 SIVIdaiVN 3IU3UA*IOd ONIiVU MOJ 6XS3X 1V3I9Q*I03IX0A 6S3SSV OX S1VId3XVH 1VXN3MIB3dX3 JO 3S0 Nouvonond r?i N39 90T BV3A M3IA3B SWB3A Q13H SWOAdldOSdO XOVdiSOV axva NI9IB0 NOIiVIlIJdV/BOHinV iOdrans ao 31aia 3dAX iNSUTlDOa N0IXV301 31IJ BSaunN N0ISS333V XVI M3AI ? *00QM MVHl` 3DC01^Wai-3Aii--n/9M) 0SM (S9)HXB - . .$: ' H - 669C0 ! fSXS3|i31V3S IIVUSlSXSOQOBd IVBOiVN tbUBVl4taailKnH3 lXNIAA^OdJXXI3ZX0UNblXSnSHO3 BV3A M3IA3B SAN3UU03 MaatflN X3QNI 3IMX SHB3X 013H ** SBOidiaosaa ^^SMaXZ fM JO S9 HUM V X3S S 39Vd -fr ", ' 10Q-IOO- ZIM-6SZSIX-X20O90 UaSNON MdOdO ^ , SINOr ABV9 HOJ XOOiNIBd 44 PRINTOUT FOR GARY JONES ORDER NUMBER 860627-135259-WIZ -001-001 PAGE 54 SET 4 WITH 385 OF 365 ITEMS ' ; \.;p REVIEN YEAR 1995 Tr4 ijfc r * >V *iv, 6f m - ITEM 143 U- Wfc- ACCESSION NUMBER 1384 ^ FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT JOURNAL APPROACHES TO THE EVALUATION OF THE TOXICITY OF DECOMPOSITION PftOOUCTS OF POLYMERIC MATERIALS AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT UNDER THERMAL STRESS ANOERSON RCUNIV OF PITTSBURGHJALARIE YC.SAME; J OF COMBUSTION TOXICOLOGY,VOL 5 PP.214, 1978* MAY THERMAL DECOMPOSITION PRODUCTS FROM SEVERAL POLYMERIC MATERIALS WERE INVESTIGATED USING DEATH AN AN INDEX OF TOXICITY. THE DATA WERE ANALYZED IN SEVERAL WAYS AND ARE PRESENTED. IT MAS CONCLUDED THAT A CONCENTRATION-RESPONSE RELATIONSHIP IS ABSOLUTELY ESSENTIAL TO MAKE VALID COMPARISONS BETWEEN MATERIALS AND THAT THE TIME TO A TOXIC EFFECT APPROACH IS NOT BROAD ENOUGH TO PERMIT SUCH COMPARISONS. DESCRIPTORS **** PVCiCOMBUSTION;TOXICITYEFFECTSACUTE * THERMAL DECOMPOSITION*,PLASTICS? HELO TERMS SMALL SCALE TESTS*NATIA3AL PRODUCTS', REVIEN YEAR 1995 ITEM 144 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELO TERMS REVIEW YEAR 1362 GEN PUBLICATION TOXICOLOGIC CLASSIFICATION OF THERMAL DECOMPOSITION PRODUCTS OF SYNTHETIC AND NATURAL POLYMERS ALARIE YUNIV OF PITTSBURGHJANOERSON RCtSAME? TOX ANO APPLIED,VOL 57 PP.181-168? 1961 A CLASSIFICATION IS PRESENTED FOR THE ACUTE TOXICITY OF SMOKE FROM SYNTHETIC AND NATURAL POLYMERS. THE CLASSIFICATION COMBINES BOTH THE AMOUNT OF POLYMER REQUIRED TO PRODUCE SUFFICIENT SMOKE RESULTING IN 50X MORTALITY(LC50) ANO THE EXPOSURE DURATION NEEDED FDR SUCH AN EFFECT (LT50). THE CLASSIFICATION SHOULD BE USEFUL FOR SELECTION OF MATERIALS IN VARIOUS APPLICATIONS. combustion;toxicity;plastics;pvc;effects;acute;therhal decomposition;mice; NATURAL PRODUCTS;SMALL SCALE TESTS! 1995 ITEM 145 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 1380 GEN REPORT TOXICITY OF PLASTIC DECOMPOSITION PROOUCTS BARROW CS.UNIV OF PITTSBURGH?STOCK M,SAMEJALARIE Y.SAHE? UNIV OF PITTSBURGH 1976, APRIL 6 IN THIS REPORT ALARIE STATES THAT THE RD50 IS RAPIDLY INCAPACITATING TO HUMANS. HOWEVER, POTTS ANO LEOERER HAVE SHOWN THAT THIS IS NOT TRUE. ALARIE ALSO REPORTS HERE THAT THE SENSORY XRR1ATION RESPONSE FOR PVC-A,PVC-B, AND PVC-C IS DUE TO SOMETHING MORE THAN HCL ALONE 20S38Q55 r ' r`r'Y PRINTOUT FOR 6ART JONES OROER NUMBER 660627-135259-WIZ -OOX-OOl , PAGE 55 SET 4 WITH 565 OF 365 ITEMS * fritr le i DESCRIPTORS HELD TERMS REVIEH YEAR ** COMBUSTIONJTOXICITY;ACUTE{EFFECTS!HYDROGEN CHLORIOE! TH effects; . :.& RD50tSMALL SCALE TEST? RESPIRATORY' DEPRESSIONIPQLTUR 1992 ;rlvs' ITEM 146 ACCESSION NUMBER 1376 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT REPORT . ,. TOXICITY OF SMOKE EMITTED FROM 4 COMMERCIAL SAMPLES WEN HEATED AT 20 DEGREES C/HINUTE5 AND ATTEMPTS TO PROJECT THE HAZARO IN HUMANS s AUTHOR/AFFILIATION ALAR1E Y.UNIV OF PITTSBURGH; ORIGIN UNIV OF PITTSBURGH DATE ABSTRACT 1962. APRIL 5 THIS IS A REPORT WHERE ANIMALS ARE EXPOSED VIA A TRACHEAL CANNULA SUPPOSEDLY TO COMPENSATE FOR THE FACT THAT MICE CANNOT MOUTH BREATH. THIS METHOD IGNORES THE SCRUBBING OF THE BUCCAL CAVITY. HOWEVER. MORE IMPORTANTLY ALARIE HAS NEVER SHOWN THAT MICE ARE LESS SENSITIVE THAN MAM. HCL AND CO LEVELS FROM PVC DECOMPOSITION ARE ALSO SHOWN. DESCRIPTORS WHMfMHH comoustion;toxicity;pvc;mooo;acute;effect8!Mice}THERMAL decomposition; HELD TERMS SMALL SCALE TEST)TRACKEAL CONNOTATION; l". REVIEW YEAR 1995 V ITEM 147 ACCESSION NUMBER FILE LOCATION 1375 GEN .' DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT TOXICOLOGIC AW ACUTE LETHAL HAZARD EVALUATION OP THERMAL DECOMPOSITION PROOUCTS OF SYNTHETIC AND NATURAL POLYMERS AUTHOR/AFFILIATION ALARIE YC.UNIV OF PITTSBURGH;ANOERSON RC.SAMEJ ORIGIN DATE TOX AND APPLIED.VOL 51 PP.541-562; 1979 ABSTRACT TOXICOLOGIC AND ACUTE LETHAL HAZARD EVALUATION OF THERMAL DECOMPOSITION THERMAL DECOMPOSITION PRODUCTS FROM A SERIES OF CELLULAR SYNTHETIC POLYMERS AND SEVERAL OTHER POLYMERS. SYNTHETIC OR NATURAL, WERE INVESTIGATES. EVALUATION OF SENSORY IRRITATING PROPERTIES, PHYSIOLOGICAL STRESS. ASPHYXIATION,ACUTE MORTALITY, AND HISTOPATHOLOGICAL CHANGES DUE TO THE THERMAL DECOMPOSITION PRODUCTS REVEALED A VERY HIDE RANGE OF POTENCY AMONG THEM. A CLASSIFICATION SYSTEM IS PROPOSED FOR MAKING COMPARISON TO STANDARO MATERIALS SUCH AS HOOD OR FIBER6LASS INSULATION ANO AN ACUTE LETHAL HAZARD SYSTEM IS PRESENTED FOR COMPARISON OF MATERIALS USED FOR THE SAME FUNCTION, I.E., INSULATION. DESCRIPTORS _HELO TERMS COMMENTS REVIEW YEAR #**#** cohbustion;toxicxty;plastics;pvc;effects;hice;acute;therHal products; natural prooucts;synthetic products;small scale tests; RKH(65) CO GENERATION FOR DOUGLAS FIR SHOWN ON P.352. 1995 decomposition; decomposition ITEM 146 -A!'' ACCESSION NUMBER 1374 208980*6 i<nr vn o eft f t I r" f" t<>Mr n'P MAPY If'Mrn f > * BFG52746 PRINTOUT FOR GARY JONES OROER NUMBER 860827-135259-NIZ -001-001 /-' PAGE 56 SET 4 WITH 365 OF 3S5 ITEMS >4 FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN GEN EPA REPORT ASSOCIATION BETWEEN BIRTM DEFI AND EXPOSURE THERIAULT GP*NONE}ITURRA H.l ftGINGRAS S.NONEt EPA,REPORT NO. EPA 600/i- \7l DATE ABSTRACT 1981 AUGUST SHAMINIGAN HAD AN EXCESffOF BIRTH DEFECTS WHICH FLUCTUATED SEASONALLY IN A MAY THAT COULD CORRESPOND TO CHANGES I# VCM CONCENTRATION IN THE ENVIRONMENT. MOTHERS WHO GAVE BIRTH TO HALFORMED CHILDREN WERE YOUNGER ON AVERAGE IN SHAHINIGAN THAN IN THE COMPARISON COMMUNITIES. HOWEVER, THERE HAS NQrEXCESS OF STILLBIRTHS IN SHAHINIGAN, THE EXCESS OF BIRTH DEFECTS INVOLVED MOST SYSTEMS, AND VARIATION IN BIRTH-OEFECT RATES AMONG SCHOOL DISTRICTS COULD NOT BE ACCOUNTED FOR BY ESTIMATES OPfVCM IN THE ATMOSPHERE. THE OCCUPATIONAL AND RESIDENTIAL HISTORIES OF PARENTS WHO GAVE BIRTH T04ULF0RMED INFANTS HERE COMPARED NITH THOSE OF PARENTS OF NORMAL INFANTS. THE TWO GROUPS DID NOT DIFFER IN OCCUPATIONAL EXPOSURE OR CLOSENESS OF RESIDENCE TO THE VINYL CHLORIOE POLYMERIZATION PUNT. DESCRIPTORS VCMiBIRTH DEFECtSiHUMAN;EPIDEMIOLOGY,EFFECTS: HELD TERMS REVIEW YEAR LAVAL UNIV; 1991 ITEM 149 ACCESSION NUMBER 1370 FILE LOCATION GEN $ DOCUMENT TYPE PUBLICATION ' TITLE OR SUBJECT PRENATAL SUSCEPTIBILITY TO CARCINOGENESIS' BY XENOBIOTIC SUBSTANCES INCLUDING VINYL CHLORIDE AUTHOR/AFFILIATION RICE JM.NCI; A ORIGIN ENVIRONMENTAL HEALTH PERSPECTIVES,VQL 41 PP.179-166; DATE 1981, OCTOBER .A ABSTRACT THE CARCINOGENICITY OF VINYL CHLORIDE FOR EXPERIMENTAL ANIMALS HHEN ADMINISTERED TRANSPLACENTALLY IS REVIEWED IN COMPARISON WITH KNOWN TRANSPUCENTAL CARCINOGENS, INCLUDING THOSE THAT, LIKE VINYL CHLORIDE. ARg-^DEPENDENT ON ENZYHE-MEDXATEO METABOLIC CONVERSION TO A REACTIVE INTERMEDIATE IN MATERNAL OR /ETAL TISSUES. VINYL CHLORIDE IS CONVERTED BY MIXED-FUNCTION OXIDASES TO THE REEACTIVE METABOLITE*CHLOROOXIRANETHE CARCINOGENICITY OF WHICH IS ALSO REVIEWED. VINYL CHLORIDE IS UNEQUIVOCALLY*:A TRANSPLACENTAL CARCINOGEN FOR THE RAT. NO EVIDENCE EXISTS, HOWEVER, TO SUPPORT THE HYPOTHESIS THAT EXPOSURE OF MALE RATS TO VINYL CHLORIDE OR ANY OTHER CARCINOGEN CONFERS AN INCREASED RISK OF TUMOR DEVELOPMENT ON THEIR PROGENY. MANY STRUCTURAL ANALOGS OF VINYL CHLORIDE, I.E., SUBSTITUTED ETHYLENES, ARE ALSO CARCINOGENIC FOR ADULT ANIMALS, AND CAN WITH CONFIDENCE LIKEWISE<BE PREDICTED TO BE EFFECTIVE TRANSPUCENTAL CARCINOGENS.ALSO SEE KWIC 045891 PAPER). DESCRIPTORS ***#* TRANSPLACEWTAL CARCINOGEN;VCM;FETAL TOXICITYJRATJ CARCINOGENICITY; REVIEW YEAR 1991 ITEM 150 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN 1367 GEN PUBLICATION SCIENTIFIC AND TECHNICAL ASSESSMENT REPORT ON VINYL CHLORIDE AND POLYVINYL CHLORIDE none,none; - : EPA,600/6-75-004; V? I ''"Ilr'iir fnrj r.ijy infirm PRINTOUT FOR BART JONES OROER NUMBER 860917' 135259-UXZ -001-001 'J.' PAGE 57 SET 4 WITH 385 OF 38$ tttttt # DATE DESCRIPTORS REVIEW YEAR ITEM 151 1975, JUNE PVCJVCMIHUMANJEFFECTSJANALT 1990 FRISK,-ASSESSMENT!, t\' rV 20898058 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHDR/AFFILIATIOM ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 1366 6EN PUBLICATION ,r' INFLUENCE OF EXPOSURE MODE ON JFINYL CHLORIDE ACTION JEORYCHOWSKI RA,NONE;SOKAL J/kNONE{CHMIELNICKA J,NONE{ ARCH TOXICOL,VOL 55 PP.195^(96; 1986 RATS MERE SUBJECTED TO AMOURS CONTINUOUS OR INTERMITTENT EXPOSURE TO VINYL CHLORIDE (VC) AT DIFFERENT TIME-WEIGHTED AVERAGE CONCENTRATIONS (15,50,150,500 AND 15,000 MG/M3). AT AVERAGE CONCENTRATIONS OF 50 MG/M3 AND 150 MG/M3, THE URINARY EXCRETION QF TD6A UNOER CONTINUOUS EXPOSURE DID NOT DIFFER FROM WAT UNDER INTERMITTENT EXPOSURE,WHEREAS AT VC CONCENTRATIONS OF 500 NG/M3 AND 15,000 MG/M3 IT NAS HIGHER FOLLOWING CONTINUOUS EXPOSURE: > VCM;RATS;INHALATION{METABOLISM!EFFECTS{ MEDICAL ACADEMY (jbLANO); 1991 \n o V* (ft ITEM 152 ACCESSION NUMBER 1365 FILE LOCATION DOCUMENT TYPE GEN PUBLICATION J, TITLE OR SUBJECT EXPERIMENTAL CONTRIBUTIONS IN IDENTIFTtfa BRAIN POTENTIAL CARCINOGENS IN THE PETROCHEMICAL INDUSTRY AUTHOR/AFFILIATION MALTONI C,NONE{CILIBERTI ANONECARRETTI d,none; ORIGIN ANNALS OF THE NEW YORK ACADEMY pF SCIENCES,PP.216-249$ DATE 1982 DESCRIPTORS ***# CARCIN0GENICITYiBRAIN$TUM0RS)EFFECT5iVCM;ACRYL0NZTRILE;BIS-CHL0R0METHYL ETHER {HYDRAZINE{TRIAZINE; HELD TERMS AROMATIC HYDROCARBONS{NITROSOUREAS5INSTITUTE OF ONCOLOGY (ITALY); REVIEW YEAR 1991 ITEM 153 ACCESSION NUMBER 1364 ^ FILE LOCATION GEN ./ DOCUMENT TYPE REPORT / TITLE OR SUBJECT THE 1955-1959 U.S. MORTALITY TABLES FOR AGE 85 AND OVER AUTHOR/AFFILIATION ARMSTRONG B,NONE{GREENBURG D,NQNE{ ORIGIN `date NONE 1976, JUNE ABSTRACT MORTALITY TABLES FOR U.S. POPULATION. USED FOR RISK ASSESSMENT OF VCM FOR THE CALIFORNIA AMBIENT AIR STANDARD. f DESCRIPTORS ******* VCMIRISK ASSESSMENT{MORTALITY, HELD TERMS U.S.BUREAU OF VITAL STATISTICS; STATISTICS; ^ REVIEW YEAR 1990 W I inv i, PRINTOUT FOR GARY JONES OROER NUMBER 860627-135259-MIZ -001-001 PAGE 58 SET 4 MITH 385 OF 385 ITEMS -:r 20898059 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR ITEM 155 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEH YEAR 1363 ' GEN publication _ THE EFFETS OF ORGANIC COMPOUNDS USED IN THE MANUFACTURE OF MifctlCS ON THE PESPCHStVltY OF MURINE AND HUMAN LYMPHOCYTES THURMAN GB.UNIV OF TEXASJSIMMS BG,SAME;G01DSTEIHAL,SAME1KILIAN OJ.SAMEl TOX ANO APPLIED,VOL 44 PP.617-641; 1978 THE EFFECTS OF ACUTE EXPOSURE TO A NUMBER OF INDUSTRIALLY IMPORTANT ORGANIC COMPOUNDS ON THE IMMUNOLOGICAL RESPONSES OF HUMAN AND MURINE LYMPHOCYTES NERE STUDIED. THE COMPOUNDS MERE BENZENE* 1-4-DIOXANE, TOLUENE DIISOCYANATE (TDI),VINYL CHLORIDE ETHYLENIMINE* AND EPICHL0R0HYDR1N. CONTROL COMPOUNDS KNOUN TO HAVE IMMUNOLOGICAL EFFECTS MERE AZOTHIOPRINE, HYDROCORTISONE ACETATE, ANO TRIETHYLENE MELAMINE (TEM). THE UPTAKE OF TRITIATED THYMIDINE ((3HITOR) OF LYMPHOCYTES HAS USED TO MEASURE THEIR ABILITY TO RESPOND TO MITOGENIC AGENTS* ALLOGENEIC LYMPHOCYTES, OR THE ANTIGENIC NATURE OF THE COMPOUNDS THEMSELVES. MOST OF THE COMPOUNDS HERE FOUND TO BE CYTOTOXIC TO LYMPHOCYTES AT HIGH CONCENTRATIONS. OIOXANE ANO TDI SHOWED EVIOENCE OF SPECIFIC ACTIONS ON THE IMMUNOLOGICAL SYSTEM. OIOXANE SUPPRESSED T-CELL RESPONSES NHILE AUGMENTING B-CELL RESPONSES. TDI EXHIBITED STIMULATORY EFFECTS AT SEVERAL CONCENTRATIONS TO BOTH HUMAN AND MURINE LYMPHOCYTES. THESE FINDINGS INDICATE THAT OF THE CHEMICALS STUDIEO, BOTH OIOXANE AND TOI HAVE PROPERTIES HHICH MAKE THEM CAPABLE OF AFFECTING LYMPHOCYTES IN HAYS OTHER THAN NONSPECIFIC CYTOXICITY. THESE PROPERTIES MAKE TDI AND OIOXANE ESPECIALLY INTERESTING UHEN MONITORING IMMUNOLOGICAL SYSTEMS OF INDUSTRIAL WORKERS HHO HAVE BEEN ACCIDENTALLY EXPOSEO TO THESE COMPOUNDS AT HIGH CONCENTRATIONS OR HHO ARE ROUTINELY EXPOSED TO MINIMAL LEVELS OF THESE COMPOUNDS. benzene;tdi;vcm;vocu*4-oioxane;epi;in vitro;lymphocytes;effectsj ETHYLENIMINEJIMMUNOLOGIC EFFECT; CYTOTOXICITY* 1990 1362 GEN PUBLICATION MITOCHONDRIAL CHANGES IN HEPATOCYTES OF RATS CHRONICALLY EXPOSEO TO VINYL CHLORIDE AND ETHANOL MILLER MLUNIV OF CINCINNATI;RADIKE MJ,SAME;ANDRIHGA A,SAME{BINGHAM E, SAME; ENVIRONMENTAL RESEARCH,VOL 29 PP.272-279? 1982 CHRONIC EXPOSURE OF HALE RATS TO 600 PPM VINYL CHLORIDE (VC1 OR VC AND SX ETHANOL (ETOH) IN DRINKING HATER INDUCED ULTRASTRUCTURAL CHANGES IN THE MITOCHONDRIA OF HEPATOCYTES. AFTER 6 MONTHS OF VC/ETOH TREATMENT, HEPATOCYTE MITOCHONDRIA OFTEN CONTAINED RIGID TUBULAR PARALLEL CRISTAE ANO OILATEO CRISTAE HITH DENSE INCLUSIONS{ETHANOL INGESTION ALONE DID NOT IWUCE THESE MORPHOLOGICAL CHANGES. IN ANIMALS RECEIVING J/C ALONE, URGE FLOCCULAR DENSITIES IN THE MITOCHONDRIAL MATRIX HERE SEEN OCCASIONALLY AFTEffct MONTHS OF VC INHALATION. THE NUMBERS AND SEVERITY OF CHANGES IN MITOCHONDRIA INCREASED Ulljf DURATION OF EXPOSURE AM) AGE. THE GREATEST RESPONSES OBSERVEO IN MITOCHONDRIA OCCURRED Wllti THE COMBINED TREATMENT OF VC/ETOH. vcm;liver;rats;alcohqlJdrinking hater;effects;chronic; ! 1990 m . C* vT> o 'mit rr\n r PRINTOUT FOR GARY JONES. ORDER NUMBER B60B27-135259-HIZ -001-001 O PAGE 59 SET A WITH 365 OF 365 ITtllS ^ iizosamw - \J pi \ ACCESSION NUMBER FILE LOCATION 1361 GEN ' -r DOCUMENT TYPE TITLE OR SUBJECT PUBLICATION EFFECTS OF INDUCERS ON THE iN'VlVO COVALENT BINDING AUTHOfl/AFFILIATION FRACTIONS A f. V ' pessayhe d,none;handscheer jc,none;oescatoire v,none;dolder A,none; BENHAMOU JP.NONE* ORIGIN BIOCHEMICAL PHARMACOLOGY>VOL 26 PP.3667-3668$ DATE 1979 DESCRIPTORS *** VCM;METABOLISM5COVALENT BINDINGJIN VlVOJRATSJEFFECTS; REVIEW YEAR 1990 ITEM 157 ACCESSION NUMBER FILE LOCATION 1360 GEN - . DOCUMENT TYPE TITLE OR SUBJECT CORR r PROCEDURES FOR THE DETERMINATION OF VCM IN^CIFIERS AUTHOR/AFFILIATION ORIGIN O'MARA MM.BFG; BF6-CHEMICALTO VINYL INSTITUTED JT DATE ABSTRACT 1965, JANUARY 28 TWO DIFFERENT LABORATORIES HERE ASHED TO DEVELOP AND CONDUCT EXTRACTION TESTS TO DETERMINE THE AMOUNT OF VCM THAT MIGRATE FROM J*VC PACIFIERS. NINE OF TEN TESTS SHOWED THAT NO VCM (LESS THAN 50 PPT I MIGRATES INTO A SALIVA SIMULANT, WHILE THE TENTH SHOWED 120 PPT. BASED ON SAMPLE HEIGHT AND SALIVA SIMULANT HEIGHT, THE US PPT VALUE IN THE SALIVA IS EQUIVALENT TO 0.0033 UG WHICH IS BELOW THE FDA ACCEPTABLE OAJCY INTAKE OF 0.011 U6. DESCRIPTORS ** VCM $ PVC JMIGRATION(EXTRACT] HELD TERMS REVIEW YEAR pacifiers; 1992 ITEM 158 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS **** HELD TERMS REVIEW YEAR 1359 GEN PUBLICATION RISK ASSESSMENT OF EXPOSURE VINYL CHLORIDE STOTT NT,DOW CHEMICAL CON ANABE PGSAME; NONE,VOL 53 PP.593-595J 1981 VCMJRISK ASSESSMENT;Hl*y i;effects;carcinogenicity; PURE A APPL CHEN; 1991 159 ACCESSION NIRCER FILE LOCATION DOCUMENT TYPE 1357 GEN PUBLICATION ;^V.s; ^ i"-MHfnt|T pnn rAPY IPUFP `Si'-W ~ ,% n -v PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-HIZ -OOI-OOl '* & PAGE 60 SET 4 WITH 365 0F388 ITEMS $ TITLE OR SUBJECT EPIDEMIOLOGIC CONSIDERATIONS ^ THEt)ESXN OF ASSESSMENT IN HUMANS ^ AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT moods jsnih; NONE.VOL 58 N0.5 PP.18<tt-U*Sf^ 1979, APRIL 51 THIS PAPER DESCRIBES A SIX-STEP PROCEDURE FOR INCLUDING tt _O__L_O_G_.IC CO_ N.S.IDERATIONS _IN BOTH iUl DESIGN AND ANALYSIS OF LABORATORY TOXICITY STUDIES CONDUCTED TO ESTIMATE RISK OPTOXltlTY IN HUMANS DURING LOU-LEVEL EXPOSURE TO CHEMICALS IN THE ENVIRONMENT. DESCRIPTORS **#** RISK ASSESSMENT*,EPIDEMIOLOGYtVCMjHUMANIEFFECTStCAPCXNOGENXCXTYt,, HELD TERMS REVIEU YEAR FEDERATION PROCEEDINGS; 1991 ITEM 160 ACCESSION NUMBER 1356 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT ONCOGENIC AND MUTAGENIC RISKS IN COMMUNITIES WITH POLYVINYL CHLORIDE PRODUCTION FACILITIES AUTHOR/AFFILIATION INFANTE PF,N0NE; ORIGIN ANNALS OF THE NEH YORK ACADEMY OF SCIENCES DATE 1976 ABSTRACT AN EXCESS NUMBER OF BIRTH DEFECTS MAS REPORTED FOR COMMUNITIES WITH PVC PRODUCTION FACILITIES. THIS WORK HAS BEEN CRITIZED AS "EPIDEMIOLOGIC GERRYMANDERING". SEE THE REVIEU BY BRIAN MAC MAHON, HARVARO. ALSO SEE KUIC 01433 (PAPER). DESCRIPTORS ******* vcm;pvc;birth defectsjhumanjeffectsjepioemiology; '- HELD TERMS OHIO DEPT OF HEALTH? REVIEW YEAR 1991 V* ITEM 161 ACCESSION NUMBER 1355 FILE LOCATION DOCUMENT TYPE GEN TECHNICAL REPORT . ^ TITLE OR SUBJECT MIGRATIN OF CHLOROFORM AND CARBON TETRACHLORIDE FROM CPVC PIPE BASED ON STRIPPED RESIN AUTHOR/AFFILIATION METZGER AP.BFG-CHEMICAL; ORIGIN BFG-CHEMICAL (*TP DATE 1979, NOVEMBER 8 ABSTRACT METHANOL STRIPPING FACILITIES HERE ADDED TO THE CPVC PLANT TO REOUCE THE AMOUNT OF RESIDUAL CHLOROFORM AND CARBON TETRACHLORIDE IN THE CPVC RESINS. HIT THE ADDITIONAL STRIPPING, THE RESINS CONTAIN ABOUT 100-2QQfgpPM OF RESIDUAL SOLVENTS. EXTRACTION OF PIPE MADE UITH THIS RESIN SHOMS THAT SMALL AMOUNTS OF'THE REMAINING CARBON TETRACHLORIDE MIGRATE INTO UTER MUCH IS IN CONTACT WITH THE PIPE. THE^MOUNT MUCH MIGRATES IS VERY SMALL (<50 PPB). DESCRIPTORS ******* CPVC;PIPE;MIGRA^M1N;EXTRACTION;CHLOROFORMSCARBON TETRACHLORIDE, POTABLE HATER; HELD TERMS CHLORONATED HYDROCARBONS*. REVIEW YEAR 1991 S' ITEM 162 ACCESSION NUMBER FILE LOCATION 1354 GEN 20898061 a -'ji' BFG52750 ''Mini'iir rnn rny ifim PRINTOUT FOR GARY JONES ORDER NUMBER S608E7-1558B9-MIZ -001-001 PA6E 61 SET 4 WITH S85 OP M ITEH8 1 DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE ABSTRACT DESCRIPTORS ****** HELD TERMS REVIEW YEAR REPORT , '* ; ' PROGRESS REPORT! PUSTIC MAI KOEBEL RF,BFG; , t ` BFG 1979, SEPTEMBER ANALYSES HAVE BEEN COMPLETW^O DETERMINE THE EXTRACTIO SWflP'l1LOROraRM AND TETRACHLORIDE FROM CPVC B^FHOWHATERi THE RESIDUALS IN THE'jUAfER RANGED FROM <1 TO 6,5 PPB FOR CCL4 ANO FROM 52 TO 90 RPB FOR CHCL3. THE CHCL3 CONTENT OF THE CONTROL HATER RANGED FROM 45 TO 75 PPB WHILE THE CCL4 CONTENT OF THE CONTROL NATER HAS ALWAYS <1 PPB. i CPVC;PIPEtMIGRATIONtEXTRACTION*CHLOROFORMCARBON TETRACHLORIDE* POTABLE HATER', CHLORINATED HYOROttRBONSS 1991 ITEM 163 20898063 \n vn o r' ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR i - *u,. Item 164 1353 GEN REPORT PROGRESS REPORT! FUSTIC MATERIALS!CPVC) ^ KOEBEL RF,BFG BFG ' 1979, JULY THE CPVC GROUP HAD A HOT HATER PIPING SYSTEM CONSTRUCTED TO SIMULATE A TYPICAL DUELLING HATER SYSTEM. RESIDUALS IN THE PIPE AND FITTINGS RANGED FROM 6 TO 159 PPM FOR CHCL3 AND 45 TO 3330 FOR CCL4. THE RESIDUALS IN THE HATfff SAMPLES TO OATE HAVE RANGED FROM <1 TO 40 PPB FOR CCL4. CHLOROFORM CONTENT OF THE CgffROL HATER SAMPLE HAS ALWAYS <1 PPB WHICH IS OUR LOWER LIMIT OF DETECTION. CPVC;PIPE;MIGRATION;EXTR< TIONiPOTABLE HATERCHLOROFORH)CARBON TETRACHLORIDE; CHLORINATED HYDROCARE 1991 po ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE DESCRIPTORS ******* REVIEW YEAR 1348 GEN REPORT CALCULATIONS OF THE AMOUNT OF VCM METABOLIZED AT VARIOUS CONCENTRATIONS HINDERER RK.BFGJ BFG 1978 VCM5METABOLISM5 1990 ITEM 165 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 1347 GEN ^ REPORT J EXTRACTION.tfTUDY OF FOOD GRADE BOTTLE COMPOUND 45548 HONG FMiBFG-AVON UKE{ I'funnilT rnT) PMJY I0MF9 2088808*1 PRINTOUT FOR GARY JONES V ORDER NUMBER 860827-135259-MXZ -001-001 v. PAGE 62 SET 4 WITH 365 OF 365 ITEMS * /Jp ORIGIN DATE DESCRIPTORS HELD TERMS REVIEW YEAR ******* BFG '^ 1967* DECEMBER 27 PVC;FDA ACCEPTANCE{EXTRACTION? GEON 65542J j; , 1986 --''"Sw' pBrm*** ACCESSION NUMBER 1344 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT BIOCHEMICAL ALTERATIONS IN LIVERS OF RATS EXPOSED TO VINYL CHLORIDE AUTHOR/AFFILIATION DU JT.UNIV of louisville;sanooz jp,same;tseng mt*sahe;tamburro ch*same; ORIGIN J OF TOXICOLOGY ANO ENVIRONMENTAL HEALTH,VOL 5 PP.1119-1132; DATE 1979 ABSTRACT SPRAGUE-DAWLEY RATS HERE EXPOSED TO VINYL CHLORIOE TO DETERMINE THE EARLIEST SEQUENTIAL BIOCHEMICAL CHANGES OCCURRING MITH LIVER INJURY BEFORE ANGIOSARCOMA DEVELOPMENT.THERE HERE NO CHANGES IN SEVEN CONVENTIONAL CLINICAL BIOCHEMICAL LIVER TESTS OR IN FOUR OTHER MARKERS OF LIVER MITOCHONDRIAL, CYTOSOL* AND MICROSOMAL FUNCITON. NO SIGNIFICANT HISTOLOGICAL CHANGES HERE FOUND ON LIGHT MICROSCOPIC EXAMINATION DURING THIS EXPOSURE PERIOD. HOWEVER, WITH ELECTRON MICROSCOPY, DILATION OF ROUGH ENDOPLASMIC RETICULUM HAS SEEN IN THE ANIMALS EXPOSED FOR MORE THAN 137 HRS. DESCRIPTORS **** VCMSLIVERJRATSSANGIOSARCONA* , REVIEW YEAR 1990 . 5l. ITEM 167 ACCESSION NUMBER 1343 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT AUTHOR/AFFILIATION NEOPLASTIC RISK AMONG WORKERS EXPOSED TO VINYL CHLORIpE J,HAXWEILER RJiNIOSH;STRINGER M SAME;WAGONER JK,SAME,JONES SAMEI FALK H.COC;CARTER C.SAMEf ORIGIN ANNALS OF THE NEH YORK ACADEMY OF SCIENCES,PP.40-46; OATE 1976 ABSTRACT IN THE PRESENT STUDY OF WORKERS EXPOSED TO VINYL CHLORIDE* AN EXCESSIVE NUMBER OF DEATHS DUE TO CANCER OF THE SAME FOUR SITES NAS FOUND, VIZ THE LIVER,LUNG,ANO THE LYMPHATIC ANO CENTRAL NERVOUS SYSTEM. THE EVIOENCE, BOTH EPIDEMIOLOGICALLT AND HISTOPATHOLOGICALLY, POINTS TO VINYL CHLORIOE AS THE CAUSAL AGENT IN THE ETIOLOGY OF SUCH EXCESSIVE CANCER RISK. THE OBSERVATION OF THE CARCINOGENICITY OF VINYL CHLORIDE, FIRST IN ANIMALS AND SUBSEQUENTLY IN MAN, STRONGLY SUPPORTS THE NEED FOR CONDUCTING ANIMAL BIOASSAY PRIOR TO INTRODUCTION OF CHEMICAL AND OTHER AGENTS INTO THE INDUSTRIAL OR COMMUNITY ENVIRONS.SEE ALSO KWIC04625 (PAPER). DESCRIPTORS #*###* vcm;human;effects{carcinogenicity;epidemiology; REVIEW YEAR 1991 ITEM 168 ACCESSION NUMBER FILE LOCATION OOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AF FILIATION 1311 GEN REPORT EPIDEMIOLOGICAL STUDY OF VINYL CHLORIDE WORKERS JFINAL REPORT. NONE,none; G 5 a i5a 20898063 .gj' ta r-'M'-rmiT rnn r*ny ir>tjFP PRINTOUT FOR GARY JONES 'p'; ORDER NUMBER 660627-135259-HU -001-001 ^ PAGE 63 SET 4 WITH 365 OF 361 ITEMS - '38t2W, tk*>l ` *} t ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR NONE vr > * '* "- 1976* JANUARY EPI0EH20L0GY STUDY OF U.S. VCM/PVC WORKERS SH0H9XNC8 THIS STUDY SUPPORTS THE HYPOTHESIS THAT VQI CAUSDItUYERi ******* VCM*>PVC;HUMAN;EFFECTSiEPIDCtCUHjD6Y^ * EQUITABLE ENVIRONMENTAL HEALfittCINCI 1990 ^ W ' 'ITEM 169 ACCESSION NUMBER 1310 FILE LOCATION GEN OOCUMENT TYPE REPORT TITLE OR SUBJECT EPIDEMIOLOGIC STUDY OF VINYL CHLORIDE MORKERS EMPLOYED BY UNION CARBIDE CORPORATION,SOUTH CHARLESTON PLANT AUTHOR/AFFILIATION NONE,none; ORIGIN NONE,FOR UNION CARBIDE CORPI DATE 1976, DECEMBER DESCRIPTORS ******* VCMlHUMANIEFFECTSIEPIDEMIOLOGY I HELO TERMS EQUITABLE ENVIRONMENTAL HEALTH INCI REVIEW YEAR 1990 ITEM 170 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFXL1ATION ORIGIN DATE DESCRIPTORS ******* REVIEW YEAR 1309 GEN PUBLICATION RESULTS OF PROSPECTIVE MORTALITY STUDY ON HUMANS EXPOSED TO VC/PVC FRENTZEL-BEYME VR,NONE{SCHMITZ T,NONE{THIESS AM,NONE; NONE,none; 1976, OCTOBER PVC;VCMSHUMAN;EFFECTS!EPIOEMIOLOGY! 1991 ITEM 171 ACCESSION NUMBER 1306 FILE LOCATION GEN OOCUMENT TYPE PUBLICATION TITLE OR SUBJECT CONTEMPORARY PEST CONTROL PRACTICES AND PROSPECTS - VOL l* CARCINOGENESIS IN HAN AND LABORATORY ANIMALS AUTHOR/AFFXLIATION NONE,NONES ORIGIN NONE DATE 197S ABSTRACT STATEMENT MADE WITH REFERENCE TO VCM THAT ANIMALS OVERESTIMATE RISK OF CANCER. DESCRIPTORS ******* vcm;effects;carcinogenicity; U .- HELO TERMS RODENTS! NATIONAL ACADEMY OF SCIENCESSNAS; " REVIEW YEAR 1991 I i-'THinur rnr? r.tpy mur^ ? . . f PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-HIZ -001-001 PAGE 64 SET 4 WITH 365 ACCESSION NUMBER 1305 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT PUBLICATION ,, .. . . OCCUPATIONAL LUNG DISEASE--ASEKTS OP INORBANIC tfclBIH AUTHOR/AFFILIATION ORIGIN WAGNER JC,N0NE| NONE,PP.213-220! ' *.*; OATE ABSTRACT 1977, JUNE IN THIS PAPER THE DISEASES ASSOCIATED WITH EXPOSURE TO ASBESTOS* OTHER MINERAL FIBRES,QUARTZ, COAL AND POLYVINYL CHLORIOE ARE DISCUSSED SMITH MORE EMPHASIS ON THE POTENTIAL CARCINOGENIC SEQUELAE THAN PULMONARY FIBROSIS. DESCRIPTORS ******* PVC!ASBESTOS?LUNG?HUMAN!EFFECTS?FIBROSIS;CHRONICI HELO TERMS REVIEW YEAR ROYAL COLLEGE OF PHYSICIANS; 1991 jJTEM 173 ACCESSION NUMBER 1304 V FILE LOCATION GEN DOCUMENT TYPE PAPER TITLE OR SUBJECT AN EPIDEMIOLOGIC INVESTIGATION OF LUNG CANCER IN A MULTZXENOBIOTXC OCCUPATIONAL ENVIRONMENT AUTHOR/AFFILXATION HAXUEILER RJ.UNIV OF NORTH CAROLINA* ORIGIN UNXV OF NORTH CAROLINA DATE 1978 ABSTRACT AN EXCESS LUNG CANCER RISK (39 OBSERVED AND 27 EXPECTED) HAS OBSERVED AMONG A COHORT OF 4806 HALES EMPLOYEO AT A SYNTHETIC CHEMICAL PLANT SINCE IT OPENEO IN 1942. UPON REVIEW OF THE PATHOLOGIC MATERIAL* THE EXCESS HAS FOUND TO BE L1MITE0 TO ADENOCARCINOMA AND LARGE CELL UNDIFFERENTIATED LUNG CANCER. MANY OF THE WORKERS. HERE EXPOSED TO VINYL CHLORIDE* BUT OTHER EXPOSURES INCLUDING CHLORINATED SOLVENTS* POLYVINYL CHLORIDE (f*VC) DUST, ACRYLATES, AND ACRYLONITRILE EXISTED. THUS. DETAILED WORK HISTORIES OF EACH COHORT MEMBER ALONG HITH EXPOSURE RATINGS OF EACH JOB FOR EACH CALENDAR YEAR SINCE 1942 FOR EACH OF NINETEEN DIFFERENT CHEMICALS (OR CHEMICAL GROUPS) MERE OBTAINEO. A SERIALLY ADDITIVE EXPECTED DOSE MOOEL MAS CONSTRUCTED WHICH COMPARED THE OOSES OF THE CHEMICALS OBSERVED FOR THE LUNG CANCER CASES TO THE DOSES EXPECTED BA5E0 ON SUBCOHORTS INDIVIDUALLY MATCHEO TO THE CASES. PVC OUST APPEARED TO BE THE MOST LIKELY ETIOIOGIC AGENT. OBSERVEO AND EXPECTEO OOSES HERE THEN ANALYZED BY YEAR BEFORE DEATH TO UNCOVER THE RELEVANT LATENT PERIOD. DESCRIPTORS ##* pvc oust;vcm;lung;carcinogenicity;epidemiology{human;effects; REVIEW YEAR 1991 ITEM 174 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE 1293 GEN I ,i REPORT THE MEDICAL COMMISSION ON THE PRODUCTION OF PVC. NONE,NOME? NONE,none; 1974, OECEMBER ;'i 3jv.V "*}' nti'TnnT rno tatjy iniiF? Oftp r-%  - - V/o vi'-- '' -a-a ::: '-i ' A: JHul AtW;J uUJ iiioliui.J v-O a O' O' %$ * ^ t^ 990SG902 rivtffci S 7:v'. N39 6931 1'SSH^ii'. 1 tn : 0661 ^ ' tH3M813ajda$NVHnH!6X6A1031S0OH3V ? 'V-j, AdVftNVr `1161 4 J33 10A*HnV3H NOaiANS H3dV ]3N0N4rH NQSnNSWHaN0N*Q9 NVHNIQ*3N0N*Md d3A3I913H0H`VT1 HOOD AQTUfi 3N3I9AH IVIHlfinONI NV *11 SISA1031600B3V IVNOIlVdnDDO Nonvonend N39 0631 N0I1V301 and aaawnN Noissaoov 9l\ H3IJ UV3A M3IA3d ****** saoidiaDsao' 31VQ NIQIdO NOIAVIlIddV/UOHinV loarons ao mm 3du iNawnaoa NOI1VD01 33Id aafiMON N0ISS3DDV ill W31I 0661 !6iaadd3SNVMnH!U3AiSISA1031600a3V Aavnuvr *ia6t 133 lOA'HilvaH NOaiANa HDdV taNONTH N0SHN9W !aN0N*HHY USVNfaNON'HM 3SnOH31IHMiaNON`G9 NVWNI013NON*NA NOSOOG Aorus ivaiNna v *m sisAioaisooaav ivNaiivdmDo Nonongnd N39 1631 aV3A M3IA3d ******* saoidiaDsao aivo Hisiao Noiiviiiddv/aoHinv iDarons ao aim 3dAi iNaunooa NouvDoi and aaSUflN NQISS3DDV $11 U311 0661 (AvnaoN) oaaAH xsaoN iAiioiNaaviru isiaaddatNvunHJAiiaiNasoNisavdSNoiivaaaav ivuasowoaHoiDAdmDA 'saaxaoM OAd/woA hi Naas SNonvaaasv ivuosouoaHD ic aavnwr *si6i 13N0N`3N0N !3N0N`l OViSaillH . / dSHHiaOVd NNndSSdOd <s*v oaaAH hshgn `lurid om ahi av saaxcndua bos do Nouwiwxa nvaiaaw ahi no laoaaa AavNiwnaad ' laodaa N39 3631 HV3A M3IA3d SUdBl 013H ****** sdoidiaosaa xovaisav aivo NlSIdO Noiivniddv/aoHinv loarans ao aim 3dxi iNaunooa NOIiVDOl 33Id aaSUHN NOISS3DDV A fill ... m)xm ... . afr snna an snIu: sNvwfiH nz aaoNyo asnvo ii'V.:/--.j. >. .? 066r MAVMttON) OdOAH NSdON dJ3lNVWnHld3DNY3`WaA ^ oaM JNO afiN^Oxa oi 3Aaas aino oiron hdihn 3H ONV 'Mia awos inoKiiM si naw ao aor `aiiaiidy aaiacriHo iania ivhl iavd oansnausa w u aaaisNoa an aV3A M31A3H SUd31 013N Sd01dIdOS30 xovaisav OO%U flBC dO S9C HilH * 138 89 39Vd Too-too- nw-683Si"i3Sow aaaMnN aaoao Aavs aod inoiNiud BFG52756 PRINTOUT FOR GARY JONES ORDER HUMBER 660827 '135259-UIZ -001-061 PAGE 66 SET 6 WITH 385 OF 369 ITEMS DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATXON ORIGIN DATE DESCRIPTORS REVIEW YEAR PUBLICATION'^ OCCUPATIONAL ACROOSTEOLYSIS: I. AN EPIOEMIOLOG OIHMAH BD,NOttE;C00K HAfHQNEJimTEHaUtt MHNO ARCH ENVIRON HEAtTH.VOLIMI> 1971, JANUARY .# ACROO3TE0LYSIS}VCM;EPIDEMl0LtiGY;HUMANJEFFECtSj 1990 " ' ' '/ ontHEcx t,none* at t'- fmrm ACCESSION NUMBER 1287 ` FILE LOCATION GEN DOCUMENT TYPE PAPER TITLE OR SUBJECT VINYL CHLORIDE CONTENT OF SUBCUTANEOUS ADIPOSE TISSUE FROM VINYL CHLORIDE POLYMERIZATION NORKERS AUTHOR/AFFILIATION KNITTLE JL.CITT UN1V OF NEW YORKjFONTANARES P,SAME;DAUM S,SAMEJSELIKOFF ZJ, SAME? ORIGIN NONE DATE 1974, DECEMBER ABSTRACT SIGNIFICANT LEVELS OF VINYL CHLORIDE MONOMER MERE FOUND IN SUBCUTANEOUS FAT DEPOTS OF MORKERS EXPOSED TO THE GAS DURING THE MANUFACTURE OF POLYVINYL CHLORIDE. THE COMPOUND HAS HOT DETECTED IN A CONTROL GROUP OF UNEXPOSED WORKERS. DESCRIPTORS *** VCM;EFFECTS;HUMAN;FAT; REVIEW YEAR 1990 ' ITEM 180 ACCESSION NUMBER 1285 FILE LOCATION 6EN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT PRODIGININE (PROOUMfcSIN-LXKE) PIGMENTS FROM STREPTOVERTtCZLLlUH RUBRXRETICULX, AN ORGANISM THAT CAUSES PINK STAINING OF POLYVINYL CHLORIDE AUTHOR/AFFILIATION GERBER NN,NONE;STAHLY OP,NONE; ORIGIN NONE,VOL 30 NOiG PP.807-610; OATE 1975, NOVEMBER DESCRIPTORS ******* PVC{BACTERIA} HELO TERMS MICR00RGAN^M;APPLIED MICROBIOLOGY; RUTGERS UNIVIUNIV OF IONA; REVIEW YEAR 1991 * ITEM 181 ACCESSION NUMBER 1283 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT CONCERNING THE PRINCIPLES AND METHODS OF TOXICOLOGICAL ASSESSMENT OF VOLATILE SUBSTANCES RELEASED BY SYNTHETIC POLYHERS 'author/affiliation TRAKHTENBERG IM,NONE;BARTENEV VD,NOME;SAVITSKII IV.NONEIBALASHOV VE.N0NE5 ORIGIN NONE,VOL 33 PP.I09-112J DATE 1968, JANUARY DESCRIPTORS ******* pvc; HELO TERMS HYGIENE 6 SANITATION;PVC FLOORS; -UM'. REVIEW YEAR 1990 20898067 t'"'rniniir rno n*nv 'nnri PRINTOUT FOR 6ARY ORDER NUMBER 660627-13S259-MIZ -001-001 PAGE 67 . SET 6 HI7H 365 OF US [; ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ******* REVIEW YEAR ?< 1676 GEN GUIDELINES * VINYL CHLORIDE SCOOE OF PRACTICE FOR HEALTH WEtUtUTtONS NONE,NONE; r HEALTH AND SAFETY EXECUTIVE,PP.1-41; ' #' / *5^ 1975, FEBRUARY vcm; 1990 ITEM 183* ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ******* REVIEM YEAR 1277 GEN BIBLIOGRAPHY HEALTH EFFECTS OF VINYL CHLORIDE MONOMER: AN AIMOTATEO LITERATURE COLLECTION WARREN H,OAK RIDGE NATIONAL LABtHUFF JESAHE ENVIRONMENTAL HEALTH PERSPECTIVES,VOL 11 PP.251-251; ,, 1975, JUNE `` vcm,effects;huhan; 1990 . v4 ITEM 184 ACCESSION NUMBER 1276 ^ FILE LOCATION GEN DOCUMENT TYPE STME)ARDS - v TITLE OR SUBJECT MElCHMACHEftHALTXGE HOCHPOLYMERE (POSITIVE LIST H.GERHAMY) AUTHOR/AFFILIATION none,none; ORIGIN none*none; DATE 1974 ABSTRACT POSITIVE LIST OF ACCEPTABLE (FOR FOOO AND DRUG APPLICATIONS) ADDITIVES FOR FLEXIBLE AND RIGID *******DESCRIPTORS PVC AND COPOLYMERS. pvc;fooo aooitive;fda; REVIEN YEAR 1990 ITEM 185 ACCESSION NUMBER FILE LOCATION .DOCUMENT TYPE 'TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 1260 GEN JOURNAL ENCRUSTATION OF>CATHETER MATERIALS IN VITRO *: -I'- SRINZVASAN V,(JNIV OF ILLINOIS;CLARK SS,NONE) V NONE,VOL I06-PP.473, 1972, SEPTEMBER ENCRUSTATION MAS SIGNIFCANTLY LESS IN CATHETERS MADE OF POLYVINYLCHLORIDE AND SILICONE RUBBER MATERIA!^AND MORE IN LATEX AND TEFLON-COATED LAtEX MATERIALS, I'nvilnlll ton rtnv AUTHOR/AFFILIATION NONE. NONE; 8? Sfi: mr 38! W s S <Hnaixrmowonno-i)mo>Ha>oC-wi4rMc0mOw*HinrnO>ni nS -m4 iM-oo ~-- f>a<flZ3u0iOHaui s a c t- o h n mnm sq-4rm-C< n3nru- nou> r- <Jt m n tfl H H H C -< H f a> a o h > -t umr> mz O 2 duno'zzrcjztn or-Nmm-<r Z hw >zn m'u r<o zoz mz< n > h 3nnt r m o in z H >ao T3 <n t<johOZrt-<ICtrjnoNw n-zcoozw - a mn h r > X PI H Cl_ <OrTzMinzHt nn> p- o HI * *-<viM04 <> (>A OZ \ ' "-".T *:s G5215& Bt* v JO o 00 '^CoO * C PRINTOUT FOR 6ARY ORDER NUMBER &60627-135289-UIZ , -001-00 r\' PACE 69 SET 4 HITH 3S5 OF /"V ORIGIN DATE DESCRIPTORS HELD TERMS REVIEW YEAR BRITISH MEOXCA&J 1962, DECEMBER'IS PVC? CANCER* .v, .. IMPLANTS JPVCSPONGESf^ 1990 ITEM 190 ACCESSION NUMBER 1254 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT SARCOMAS AT THE SITE THIN IMPLANTS AUTHOR/AFFILIATION ROE FJC'NONE;DUKES/tENONE5MITCHLEY BCV'NONES ORIGIN BIOCHEMICAL PHARMACOLOGYVOL 16 PP.647-6505 DATE 1967 / DESCRIPTORS ******* PVC{CANCER{SARCOMAS{RATS* HELD TERMS IMPLANTSSPVC SPONGES* REVIEW YEAR 1990 ^ fii.- ITEM 191 ACCESSION NUMBER FILE LOCATION (DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELO TERMS REVIEW YEAR 1252 GEN PUBLICATION THE INFLUENCE OF POLYVINYL CHLORIDE IPVC) TUBING ON THE ISOLATED PERFUSED RAT'S HEART METIER FL>NONE;WILLEBRANDS AgtftiNESOURRER 0.NONES NONE,VOL 5 PP.44-46S 1960* JANUARY PERFUSION OF THE ISOLATjffRAT'S HEART THROUGH CERTAIN TYPES OF POLYVINYL CHLORIDE TUBING RESULTS IN A DETERIORATION OF CODIAC PERFORMANCE. SINCE PLASTICS ARE COMMONLY USED IN HEART-LUNG MACHINES AND TRANSFUSIOH-SETSTHIS OBSERVATION MAY BE OF SOME IMPORTANCE. pvc;plasticizer;heart;effects;rats;xn vitro; PVC TUBES{PERFUSION{CIRCULATION RESEARCH; 1990 J Item ise ACCESSION NUMBER FILE LOCATION OOCUMENT type TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ******* HELO TERMS REVIEH YEAR 1251 GEN PUBLICATION VINYL PLASTICS :THEIR DERMATOLOGICAL AND CHEMICAL ASPECTS MORRIS GE.HONES ARCHIVES OF INDUSTRIAL HYGIENE A OCCUPATIONAL MEDICINE VOLG PP.535-539} 1953 PVC{SKINSeffectsshuhan; X f&fi? DERMATOLOGY; :r 1990 * r't'rinniiT rnr? rupy muFs PRINTOUT FOR GARY JONES ORDER NUMBER 660B27-135259-WIZ -OOI-OOl PAGE 70 SET 4 WITH 365 OF 365 ITEMS ITEM 193 vl ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEH YEAR 1250 GEN JOURNAL PLASTICIZERS IN PVC AND OCCURENCE OF HEPATltXSXN A HAEHdOtALYSIS UNIT NEERGAARD J,NONE!NIELSEt {CHRISTENSEN OHNONE{HIELSEN OFftlONEI NONE*VOL 5 PP.141-145{. 1971 $ IN A FOUR-YEAR PERIQO THREE ISOLATED CASES OF HEPATITIS NERE OBSERVED HITHIN A PERIOO OF 2 MONTHS IN A HAEMODIALYSIS UNIT. THE CASES OCCURRED IN 3 PATIENTS DURING TESTING OF NEK HAEM00IALYS1S EQUIPMENT. LIVER BIOPSY IN 2 PATIENTS SHOUEO NON-SPECIFIC HEPATITIS AND CHANGES AS IN "VIRAL HEPATITIS"* RESPECTIVELY. FROM THE TESTED BLOOO TUBINGS* MANUFACTURED FROM POLYVINYLCHLORIOE (PVC)* DIAETHYLPHTHALATE HAS HASHED OUT IN AN AMOUNT OF 10-20 MG PER LITRE AQUEOUS PERFUSATE. FROM THE TUBINGS NORMALLY USED IN THE DEPARTMENT THIS COMPOUND HAS NOT RELEASED ON PERFUSION* AND THE SYMPTOMS DISAPPEARED RAPIDLY MHEN TREATMENT HITH THE USE OF THESE TU8INGS HAS RESUMED. PVC PLASTICIZERS(HEPATITIS{HUMAN{EFFECTS; 1990 frtTEM 194 ACCESSION NUMBER 1249 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT CONTACT DERMATITIS FROM PLASTICS CONTAINING TRI-ARYL PHOSPHATES AUTHOR/AFFILIATION PEGUM JS*NONE{ ORIGIN BRITISH J OF DERMATOLOGY*VOL 76 PP.626-63U DATE 1966 ABSTRACT A HOUSEWIFE HITH ECZEMA REACTED TO THE PVC STRAPPING USED IN PATCH TESTING. THE REACTION HAS THE RESULT OF SENSITIVITY TO TRITOLYL PHOSPHATE (TTPI. SHE ALSO REACTED TO TRIPHENYL PHOSPHATE (TPP) WHICH IS USED IN CELLULOSE ACETATE PRODUCTS. IN HER ENVIRONMENT SHE REACTED TO PVC COVERED FURNITURE* FLOOR TILES AND TO SPECTACLE FRAMES MADE OF ACETATE* ALSO TO PLASTIC KITCHEN UTENSILS. DESCRIPTORS ##**** PVC5CONTACT DERMATITIS{HUMAN{EFFECTS* HELD TERMS TRI-ARYL PHOSPHATES; REVIEW YEAR 1990 ITEM 195 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ******* HELD TERMS 1248 / GEN / JOURNAL / POLYVINYL CHLORIDE T-TUBES LAWSON DR*NONEf' BRITISH MEDICAL JOURNAL,VOL 4 PP.112; 1973* OCTOBER 13 PRESENT PVC TUBES NOT SUITABLE FOR USE AS T-TUBE. PVCJHUMAN{EFFECTS{PLAST1CXZEP{ PVC T-TUBES{ 320838071 09 L ^ 9 I r-nriijniir TOO Pftt?Y tnHF't PRINTOUT FOR BAR ORDER NUMBER 860*27-3U5259-WIZ PAGE 71 SETItXTff 385 OF REVIEW YEAR 1990 ITEM 196 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 1247 GEN PUBLICATION IRRADIATED PVC PLASTIC AND BAS TRACHEOSTOMY lipton b.none;gutierrez r,nonesblai S,NONE}LITNAK RS*N0NE) REHDELL-BAKER L,NONES NONE,CIK 59 BI,4 00,578-586; 1971, JULY-AUGUST IN THE REPORTING OF DAMAGE TO LARYNGEAL AND TRACHEAL TISSUE FOLLOWING PROLONGED INTUBATION, TOO LITTLE ATTENTION HAS BEEN PAID TO*THE COMPOSITION OF THE TUBE (FOR A NOTED EARLIER, RUBBER TUBES ALSO MAY NOT BE FREE FROM HAZARD) AND THE HETHOD OF STERILIZATION USED. THE MEDICAL PROFESSION MUST BE MADE AWARE OF THE POTENTIAL DANGER OF TISSUE DAMAGE FROM PROLONGED CONTACT HITH NEH MATERIALS UNDERGOING COMPOSITION OF THE TUBE (FOR AS NOTED EARLIER, RUBBER TUBES ALSO +NEH MODES OF STERILIZATION. f "(' DESCRIPTORS HELD TERMS REVIEW YEAR ******* pvc;human;effects? trachMi . TRACHEOSTOMY JSTERILIZATIONSTRACHEAL STENQSXStANESTHESXA AH) ANALGESIAS 1990 > HEM 197 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ******* HELD TERMS REVIEW YEAR 1246 GEN PUBLICATION WHAT'S IN PVC LITTLE K,NONE; NONE,VOL 2 PP.351-352} 1968 pvc; NEOICINEiTHE LANCET; 1990 ITEM 19S ACCESSION NUMBER 1245 FILE LOCATION DOCUMENT TYPE JOURNAL S .'7 TITLE OR SUBJECT TOXICITY OF PLASTICS USED IN MEDICAL PRACTICE It INVESTIGATION OF TISSUE RESPONSE IN ANIMALS BY CERTAIN UNIT PACKAGED POLYVINYL CHLORAE ADMINISTRATION DEVICES AUTHOR/AFFILIATION LAWRENCE WH,UNIV OF HOUSTON;MITCHELLjjrJL,NONE } GUESS HL,NQNE?AUTIAN JNONE( __ ORIGIN NONE,VOL 52 NO.10 PP.956-963} ' " DATE 1963 ABSTRACT THE RESULTS OF THE STUDY REVEALEDjtHAT UNDER THE EXPERIMENTAL CONDITIONS USED IN THIS STUDY A NUMBER OF THE TUBINGS MILL PRODUCgvTISSUE RESPONSE WHILE OTHERS MILL NOT. DESCRIPTORS ******* pvc;extraction;analysis;rabbit;effects; HELD TERMS REVIEW YEAR PVC TUBESIMPLANTATION}J OF PHARMACEUTICAL SCIENCES} 1990 pn t' irniit rf'n rr?Y V ' ijJUui Aiivt* duJ iiiwii>iu>i % o 'A O' Vp .* k C408S902 saaiawvo (OAd)aaittoiHO iiitxAAiod aa2niavis-NxioNV9do 01 SNOiiovad anssn V ivwanop N39 0*21 loarons do ami adiL iNaunooa N011Y001 3113 aaawnn Noissaoov 302 M31I 0661 *S3rA* rn UHivdoaov iSISAIOaiSOQdOViNOIlVZXdaUAlOd!HOA 696T JZT-S'dd S'ON 16 10A43H0N J3N0N*9 OYdYd!3NON`Q DI2nd`3Idnr<3NOM`1 V3irVdn>l`.aN0H`V 3YA0H 3SV3SIQ IVNOIlYdnOOO M3H Y--NQIlVZXdaUAIOd 3A H11N 031VI30SSV 83IlIM3dlXa aHI 30 AHlVdOdCY Nonvonsnd N39 2*21 dV3A H3IA3d SUd31 Q13H ****** suoidiaas3a 31YQ NI9IM0 Nonvn i 33v/aoHinv loarans mo ami 3dAl iNaunooa N0I1VD01 3113 diOMAN HOISS333V 103 H31I; 0661 {3M3ieAHtN0IlVlINYS OIV/aNai9AH!SdOO'M JOAd /-Advnd03d *8961 I082571#L1T3*xdd EC 10A43N0N I3N0N`13 HOIAONYW1YX S9NX1Y00 dOOId aQId01H3-lANIAA10d 30 SOtlSIdaiDYWHO lVDIWH30-AdVlINVS 9 Nonvonand N39 <931 dY3A N3IA3d SMM31 Q13H ******* edoididosaa siva NI0IU0 NOIlVIlIddV/dOHinV loarans mo ami 3dAi iNaunooa H0I1V301 3113 aaawnH noisssooy 002 H31I 0661 dY3A M3IA3M *******ison daixvfl! inoiivioossy snaa ivdaiNadVd'iina isivaaiNaavdissva oooia Jr !0001953Ad SHM31 013H 8d01dId0S30 aaaiaosaa aav sinaNOduoo oooia nywah sNxsvxovd aoti Nonvzniin sn qny 03M3IA3d atnr 83Ild2d0ad 1Y3I9010I9 ONY *IVOISAHd41Y3IM3H3 fill `aaidOIRO IAAIOd 81 NOXIVOIlddV SIHl dOd S3X18Xd313VdVH3 1YI1N3SS3 30 d39MnN V 9NISS3SOd OHS SNOIimOS 1Vd31H3dVd 9HI9VX0Yd d03 S39Y1NYAQY 30 d39HTlN V U3330 SW31SAS OIlSYId Q31VDI QNV Q3N9IS3Q AldSdOdd AOVdlSQY 9961 31V0 Sl-'dd 33 10A43N0N N19IM0 13NONTN 80NIldV NOZlVI1X33V/dOHinV Kp.lANIAAIOd NX 81Vd31N3dVd loarons do ami NOXlYOllOnd 3dAl iNaunooo N39 N0I1V001 31X3 wai diaunN Noissaoov 661 wall Stoll JTM 30 S9 H1IH * 138 31 39Yd 100-100- 2IH-6S2S1-Z38099 tf39MnH d30MO sarior Advs doa imirnud PRINTOUT FOB CARY ORDER NUMBER 660827-135259-HIZ rDD^-09 TV PACE 73 SET A HITH IAS OF^;#W . %:$l- >-' fiT^'cS*' AUTHOR/AFFILIATION ; CUESS HL.NONEjSTEtSQN ORIGIN JAMA.VOL 294 NOi7>Pii DATE ABSTRACT 1968* HAY 13 "V^-'-'V THERE HAS BEEN ANINC* LITERATURE FOR A CAUSE' CAUSE TISSUE injury; A ENDOTRACHEAL USE CAUSED ipenci ^ si . _ I>UtfLfeAAABLi ljBSTANciyH^lKyiNYL-CHUwiOE U -___ __ VEALED THAt PVC SmERS^WnMPpE CATHETERS ritttwfjFCP, __ REACTIONS WHEN IMPLANTED1 lH%jbgTHUSCLE. CELL CULTURE STUDIED HERE CORROBORATIVE. THE IC SUBSTANCE NAS IDENTIFIED AS An ORGANOTIN COMPOUND. THE INVESTIGATORS CONCLUDED. AT PLASTIC DEVICES FOR USE IN HUMAN t>ATXENTS SHOULD NOT CONTAIN ORGANOTIN STABILIZERS,fOR ANY OTHER LEACHABLE TOXIC AGENT,ANDTHAT STANDARDS FOR PLASTIC DEVICES USEO IN MEDICAL PRACTICE SHOULD BE ESTABLISHED. DESCRIPTORS PVC.ORGANOTIN STABILIZERS * RABBITSi HELD TERNS CATHETERS; IMPLANTfl REVIEW YEAR 1990 ftEM 203 ACCESSION NUMBER 1239 ' FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT CONTACT DERMATITIS DUE TO TABLE CLOTH COVER OF VINYL PLASTIC FABRIC AUTHOR/AFFILIATION HITSCHKANN OB.NONE. ORIGIN NONE.VOL 41 PP.679-681. DATE 1950 ABSTRACT THIS IS A REPORT ON ALLERGIC CONTACT 0ERHATITX3 FROM PLASTIC.TABLE CLOTH COVERS OBSERVED ON 2 PATIENTS. NO DESCRIPTION OF ANY SIMILAR CASE HAS FOUND IN THE LITERATURE. DESCRIPTORS **** PVC;DERMATITIS;HUMAN;effects; HELD TERMS TABLE CL0TH;FLEX1BLE;ARCHIVES OF DERMATOLOGY AND SYPHILOLOGYl REVIEN YEAR 1990 ITEM 204 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS *##*##* HELO TERMS REVIEW YEAR /1237 GEN JOURNAL USE OF SUBCUTANEOUS PV IMPLANTS FOR THE STUDY OF EXPERIMENTAL ATHEROSCLEROSIS JACOTOT PB.NONE.BEAUMON7JL.NONE; NONE,VOL 9 PP.28-29; / 1967 ' PVC;RATS;RABBITS;SUBCUTANEOUS. implants;atherqscjj!posis;revue L'atherqsclerdse; 1990 .ITEM 205 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 1236 GEN JOURNAL MIGRATION OF A PHTHALA BLOOD AND ITS LOCALIZAT i'V v. ESTER PLASTICIZER FROH POLYVINTL CHLORIDE BLOOD BAGS INTO STORED HUMAN in hunan Tissues ,F G 5 2 7 6 3 ? Jr po t'PMir*'HT rnn harv muF*? PRINTOUT FOR GARY JONfcS iM ORDER NUMBER 660B27-135259-HXZ 001-001 PAGE 79 SET 4 KITH 365 OF 365 XTENS AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR JAEGER RjN0N6RbBXN AjNONE| NONE,VOL 267 NO.22 PP.1114-11181 1972* NOVEMBER SO . >t A PLASTICIZER* DI-2-fcTHTLHEXtt FROM POLYVXHfjP PLASTIC BLOOD BAGS BY BOTH HU|ttN. AT A RATE OF 'CSi MINUS 0.03 MG PER 100 ML PER DAW PLASTICIZER LIPID-CONTAINING LIPID-FREE FRACTIONS OF PUSMAJheREAS RED CELLSCONTAlNEOONtYHlNOR AMOUNTS. SEVEN OF 12 LUNG-TISSUE SAMPLES TAKEN AT AUTOPSY FROM PATIENTS MHO HAD RECfiiVED TRANSFUSIONS OF StORED BLOOO CONTAINED OETECTABLE AMOUNTSW PLASTICIZER. ONE PATIENT* AFTER OPEN-HEART SURGERY* EXCRETED A URINARY METABOLITE OF THE PLASTICIZER IN EXCESS OF THE AMOUNT CALCULATED TO HAVE BEEN RECEIVEO IN THE TRANSFUSED BLOOO. THE JlOOITIONAL METABOLITE POSSIBLY CAME FROM PLASTICIZER EXTRACTED FROM THE POLYVINYL CHLORIDE TUBINQ^OF THE CARDIOPULMONARY UNIT. ALTHOUGH THE TOXICOLOGIC IMPLICATIONS OF THESE OBSERVATIONS ARE NOT CURRENTLY KNOWN, IT IS SUGGESTED THAT PLASTIC FORMULATIONS THAT DO NOT CONTRIBUTE ANY EXTRACTABLE MATERIALS TO BLOOD OR ITS FRACTIONS BE DEVELOPEO. pvc;migration;blooo*,human;effects;deposition; dehp; BLOOD BAGSSNEN ENGLAND J OF MEDICINE;JOHNS HOPKINS UNIVS 1990 ITEM 206 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS **** HELD TERMS REVIEW YEAR 1235 GEN 0 PUBLICATION * PLASTICIZERS PROM PVC JAEGER RJNONE;RUBIN RJ.NONEJ NONE V0L 2 PP.776J 1970. OCTOBER 10 PVC;PLASTICIZERS5 DEHP 5BLOOD; MIGRATION; THE LANCETJJOHN HOPKINS UNIVSBLOOO BAGS;PHTHALATE ESTERS; 1990 ITEM 207 ACCESSION NUMBER 1239 FILE LOCATION DOCUMENT TYPE GEN JOURNAL ^gr -f? TITLE OR SUBJECT PLASTICIZERS IN HUMAN TISSUES AUTHOR/AFFILIATION nair pp,none;rubin rj,ndne; ORIGIN NONE,VOL 288 NO.17 PP.915-916i DATE 1973, APRIL 26 j ABSTRACT HOWEVER* QUALITATIVELY HE FIND THE SAME FREQUENCY OF APPEARANCE OF DEHP IN THE TISSUES OF NONTRANSFUSEO PERSONS. DESCRIPTORS KMK* PVC;PLASTICIZEREMIGRATION{BLOOOiHLMAN;EFFECTS(INTRAVENOUS* .HELD TERMS REVIEW YEAR transfusion;*#* England j of medicine;jqhn hopkins univjmounT sinai hospital; 1990 ITEM 206 ACCESSION NUMBER FILE LOCATION 1231 GEN -r" :;A:- m V.- . -j, 20898075 BFG52764 pnTMfniir rnn r*rv imjrn \ PRINTOUT TOR OAR? ORDER NUMBER 660at7-1355?-WiZ , 5 *001 PAGE 75 SET A WITH SOB OP J DOCUMENT TYPE i GOVERNMENT CORR TITLE OR SUBJECT BFG'S SUBMISSION AND COMPOUNDS . AUTHOR/AFPILIATXON OSBORNE EB,BFG-CHEMICAL ORIGIN BF6-CHEHICALTO POMS DATE 1975. AUGUST 13 i ...... DESCRIPTORS WMmtww VCM;PVe;FDA;POTABLE ftttEHlANALTSIS HELO TERMS rvcm; REVIEW YEAR 1990 STEM'soi* ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEN YEAR 1230 6EN STANDARDS PRIOR-SANCTIONED POLYVINYL CHLORIDE RESIN *NOTICE OP PROPOSED RULE MAKING NONE,none; FEDERAL REGISTER,VOL 38 NO.95 PP.12931; 1973, MAY 17 PROPOSED RULE TO AMEND PART 1E1 BY ADDING NEH SECTION 121^(009 POLYVINYL CHLORIDE RESINS. PVCSFDA', . v. 1990 ITEM 210 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS REVIEW YEAR 1229 '- '. GEN STANDARDS ,5 PRIOR-SANCTIONED POLYVINYL CHLORIDE RESIN :EXTENSION OF TIME FOR PILING COMMENTS (PROPOSED RULE) NONE,NONE; -- FEDERAL REGISTER,VOL 38 NO.134 PP.16689) 1973, JULY 13 < pvc;fda; 1990 ITEM 211 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN .OATE DESCRIPTORS ****# REVIEW YEAR ITEM 212 ACCESSION NUMBER 1228 GEN 4* >' STANDARDS VINYL CHLORIDE AS AN INGREDIENT OF DRUG AN) COSMETIC AEROSOL PRODUCTS!PINAL RULE). NONE, NONE}' -'a FEDERAL REGISTER,VOL 39 NO.166 PP.30830; 1974, AUGUST 26 .M vcm;fm; aerosol; 199Q~J '< ' W- -iiir - ' V4*; 1227 . .<? /T-* *1 itmitmiit t pr fUpy lOMr* * "f. PRINTOUT FOR 6ARY JONES ORDER NUMBER B60827-1352S9-WIZ -QOI-OOi PAGE 76 SET 4 KITH 365 OF 365 ITEMS ^ " FILE LOCATION GEN * * DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE GOVERNMENT-SORR VINYL CHURIDE FROM FC KAMPELMAn JNONEJJOHNSON;A4 NONE,T7FDA HEARING'fetERGi# 1975#JULY I ^ v -'-1 DESCRIPTORS ******* FDAifCMJPVC* HELD TERMS PUBLIC CITIZEN'S HEALTH RESEARCH GROUP! REVIEW YEAR 1490 ITEM 213 ACCESSION NUFBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN PATE DESCRIPTORS * REVIEW YEAR 1226 GEN STANDARDS PRIOR-SANCTIONED POLYVINYL CHLORIDE RESIN (TERMINATION OF NOTICE OF PROPOSED RULEMAKING) NONE,none; FEDERAL REGISTERVOL 40 NO.171 PP.40529) 1975, SEPTEMBER 3 PVCJVCMJFDAJ 1990 ITEM 214 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE descriptors wuhhhhi REVIEW YEAR 1225 6EN PAPER VINYL CHLORIDE POLYMERS IN CONTACT WITH FOOD (NOTICE OF fftOPOSED RULE MAKING) NONE*NONE! FDA,CFR121 DOCKET NO.75N-019Q; 1975r vcm;pvc;fda; 1990 ITEM 215 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ,ABSTRACT DESCRIPTORS **** HELD TERMS REVIEW YEAR 1224 GEN JOURNAL POLYVINYL CHLORIDE T-TUBES BOUCHIER-HAYES DJ*NONE{ BRITISH MEDICAL JOURNAL.VOL 3 PP.543J 1973* SEPTEMBER 8 T-TUBE IN PATIENT BECAME RIGID. pvc;human;effects; pvc t-tubes;implant; 1990 20698077 to i flV' ',iirrir f rvn pmv --W- ' PRINTOUT FOR 8ART ORDER NUMBER 66C827-1352B9-HIZ rv ; PAGE 77 MT 6 MTU 38g ACCESSION NUMBER 1223 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT HISTOLOGICAL AM HIS CHLORIDE PNEUMOCONIOSIS AUTHOR/AFFILIATION CYLUIK BtNONEl . ORIGIN NONE,VOL 17 PP.93-111) DATE 1973 DESCRIPTORS **** pvc;liver; HELD TERMS pneumoconioses; REVIEW YEAR 1990 ITEM 217 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS **** HELD TERMS REVIEM YEAR 1222 GEN PUBLICATION WHAT'S IN PVC COWPER sg,none; NONEeVOL 2 PP.221) 1968, JULY 27 PVC TUBINT pvc;migration;acute; SHISTOSOMA MANSONi;LETHALITYJMORMSiTHE LANCET) 1990 ITEM 218 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTKOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS <hhhhw HELD TERMS REVIEN YEAR 1221 -. -> GEN ^ JOURNAL & HAZARDS FROM PLASTICS STERILIZED BY ETHYLENE OXIDE CUNLIFFE AC,KING'S COLLEGEiNESLEY FSAME) BRITISH MEOICAL JOURNAL,VOL 2 PP.575-576) 1967, MAT 27 PVC ABSORBS ETHYLENE OXIDE WHICH CAN THEN MIGRATE. pvcjmjgration; STERILIZATION) ETHYLENE OXIDE) i^d ITEM 219 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 1220 GEN m. JOURNAL PARTICULATE LYVINTL CHLORIDE INTRAVENOUS BABS DARBY TKtNONE) RK,NONE) ^ '' -V NONE,VOL 290 PP.B79) 1976, MARCH THE SOURC HUMAN EXPOSURE TO PLASTICIZER IS NXTHXH THE ENVIRONMENT AS DEMONSTRATED IN i"miiiihii r''n rapy mum t : i ; bdNui AtJvJ dUJ iiiuiluuJ *?> { fete ?'.rhr- * imssna) iviidsoH loiaiozo lYtwoxtNoxiYiiHvs onv 3N3I9ah;s3iii 0661 13N3I9AHJSB001J iOAd 016T -636*dd S 10A`3N0N ?3NON`VX XmttVA.a 61N3UltfVdV dOJ 63111 dOOId 3Ad 30 N0XlVmVA3 OIN39AH 3HI 01 NOIingidlNOD V . Nonvonand N39 113t 33 W31I HV3A M3IA3M 6HH31 013H ******* SU01dIU3S3Q 3iva` NZSIBO NouvniddT/dOHinv loargns ao aim 3dAi lN3Wn30a NOI1VOQ1 3113 d3amN N0ISS303V 333 H311 0661 *(N00N01) 100H38 1V3I03U IVIXdSOH xasaiaaiHUIONYI 3HiiN0IlYltoai319NI0TU OAd 18133333i00019 SH0I1VB9IUS61VO1 OAd *9NK3rU^I3Ad) 3Gia01K01ANIAA1Od UOH3 30VM AlliiVdfil linOdlO N0ZSI13U3d 3HI N3HH VZXOdAH 01 0N0dS3d ION OOSSNOI .BiVO Q3Sn3d3d OaiVIOSX 30 6136S^S*00019 AaVNOWIfld 3H1 9 Ainr *8961 i3"I3"dd Z 10A*3NON 'Hr 3NVA!3N0N`NH SHOO Nonnnoaro ivaaodaooYiuxa hi oasn sniou aaiaoiHoiiWAiiod 30 103333 asasAov nv ivNdnor N39 8T3I tiVSA i13IA3d SUU31 013H ****** saoidiaosaa iovdisav 31VQ NI9IdO NOiivnudv/aoHinv loarans ao aim 3dAi iNawnooa N0I1V001 31T3 uaeunN Noissaoov 133 uaii 0661 IN019NIH6VH 30 NOIinillSNI 3I93NdY3fA9010I9 Hta3NH^/fHafrUuVi N59NI8TU OAd i suazxoxisnd f ainovsMZOixoi1arissn i noiivuozh j OAd 'saannno anssii 01 ozxoi aav hoxhn siNvoixpl eaHOvai sniou oad 6T AVW 4U6T i98-S8*dd T3 10A*3N0N !3NON`ia NVVH 30 OIlSYId aOZHOlHO IlNlMIOd 01 03603X3 V 100 30SSZ1 30 A1I0IXO1 NOIlVOIiand N39 6131 dV3A M3IA3d 6UU3A 013H ****** eaoidiaosaa 10VU1S8V 3iva HIDIdO NOZlvni33V/dOHinV loarans ao aim 3dAl iNawnooa N0I1V001 3113 aasuriN Nozssaoov ' iHtsiSr V' Wi:& - . W r *m*a ainvHiNdi Yd 036n36NYdl A1ZAV3H q NX aoHauiddiQ on V* 032 W31I v ..... 066t axvivKiHdissva ooois [qtstiazioiisnd SdHSOi OAd NNN9(W*V aasnasNYtu-NQN 30 SNOiinndOd 6308811 ASdOinV dO 6ISA1VNY HV3A M3ZA3B SWdil 013H saoidiaosao > 8H31Z fiofe d0 S9 H1IM * 138 91 39Vd tOO-TOO- ZIH-6S3SZT-139099 B39HnN d30U0 sanor Auvs tnd inoiNzud V K: PRINTOUT FOR GARY ORDER NUMBER 860827-135259-HIZ - . 001*-0 PA6E 79 SET A WITH 385, OP - -j ACCESSION NUMBER * 1216 FILE LOCATION - GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT THE INFLUENT AUTHOR/AFFZL3ATION DUKE HNtNONE} V. ORIGIN NONE,VOL 38P,24P}:- OATE 1970 ABSTRACT THE PRESENT EXPERIMENTS BEEN INCUBATED CAN INHI PERFUSED CAT LUNG PREP/ DESCRIPTORS ******* PVCMIGRATION;VASCU1 HELD TERMS PVC TUBINGiFLEXIBLlJVASCULAR RESISTANCE{CIRCULATION; CLINICAL SCIENCE} REVIEW YEAR 1990 ITEM 224 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ******* HELD TERMS KHIC INDEX NUHBER REVIEW YEAR 1206 GEN COMPANY CORR FOA STATUS OF 6EON RESINS NONE,NONE, BFGTQ HOOKER CHEMICAL} 1968, NOVEMBER 13 FDA ACCEPTANCEfRESINlGEONSJ GEON XOlfGEON lOJtGEON 104} 00386CORR 1990 v.V? STEM 225 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ******* KMIC INDEX NUMBER REVIEN YEAR 1196 GEN JOURNAL ANGIOSARCOMA OF THE LIVER IN VINYL CHLORIDE/ POLYVINYL CHLORIDE WORKERS NONE,NONE; J OF OCCUPATIONAL MEDICINE ,VOL 16 NO.12} 1974 ANGIOSARCOMA} LIVER} VCM} PVC} Q0377PUBL 1990 ITEM 226 ACCESSION NUMBER 'file LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE 1187 ' -rs* f . GEN PAPER CYTOGENETIC STUDIES OF BONE MARROW CELLS FROM RATS EXPOSED TO VINYL CHLORIDE JOHNSTON RV,DOH CHEMICAL CO}HENSIK DJSAMC}PIM(ERTON MNiSAMEj ` MURTON EB,UNIV OF TEXAS} DOW CHEMICAL CO,FOR MCA ' "* "/ 1975 -- tk v, .. 2089308(1 *1 $ vA o rmruinur rtvp papy iohfs PRINTOUT TOR GARY JONW ORDER NUMBER B60827-135259-MU , -OOl-OOl PAGE 60 SET * HITH MS OP 965 STEMS > ^ ABSTRACT STUDIES BY THE BIOMEDtCAL ANO COMPARATIVE TOXICOLOGY RESEARCH ________ '-- - .__ _ . k a a as COMPANY,FREEPORT* TEXAS* SHOW THAT THERE MAS NO SIGNIFICANT LABOIREAv,TISNOl RmTYHsEOPMCiTHlMHRAOEifMWDOOMSWBOAMCAtHL EtHM ICAL ABERRATION RATES OF BONE MARROW CELLS OF RATS EXPOSED TO ES OF VINTL FOR ONE YEAR AT INDUSTRIAL BIO-TtST. IIBORATOIUES, DECATUR.^* DESCRIPTORS **** MUTAGENICITY! VINYL CHLORIDE; hONOMER! BOMTMARlWI tftoNitNHA HELD TERMS KNIC INDEX NUMBER CYTOGENETIC EFFECTS! CHROMOSOMAL ABNORMALITIES ^ 00367PAPE - 3$ REVIEW YEAR 1990 *: } 'A STEM 227 : ACCESSION NUMBER 1182 * ' PILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION JOURNAL CARCINOGENICITY BIOASSAYS OF VINYL CHLORIDE * 1.RESEARCH PLAN AND EARLY RESULTS LEFEMINE G.NONE* MALTONX C.NONEJ ORIGIN ENVIRONMENTAL RESEARCH*V0L 7 PP.387-405! DATE ABSTRACT 1974 THESE INVESTIGATIONS ARE CONCERNEO WITH DETERMINING THE ONCOGENIC POTENTIALITIES OF VINYL CHLORIDE (VC) IN EXPERIMENTAL ANIMALS. THE EFFECT OF THIS COMPOUND IS BEING STUDIED IN RELATION TO VARIOUS EXPERIMENTAL FACTORS* SUCH AS ROUTE OF ADMINISTRATION* DOSE LEVEL*LENGTH OF TREATMENT SPECIES* STRAIN* AM) AGE OF THE ANIMALS. PRELIMINARY RESULTS ARE PRESENTED. WHEN GIVEN BY INHALATION* VC INDUCES IN RATS* ZYMBAL GLAND CARCINOMAS, NEPHROBLASTOMAS* AND ANGIOSARCOMAS OF THE LIVER AND OF OTHER ANATOMICAL SITES! AND IN MICE* PULMONARY ADENOMAS* MAMMARY CARCINOMAS AND LIVER ANGIOSARCOMAS. A DIRECT RELATIONSHIP HAS BEEN FOUND BETWEEN DOSE AND LENGTH OF TREATMENT AND NEOPLASTIC RESPONSE. DESCRIPTORS ***#* VINYL CHLORIDES CARCINOGENICITY! INHALATION* MICE! RATS! KWIC INDEX NUMBER 00362PUBL REVIEW YEAR 1990 ITEM 226 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTH OR/AF FILIATION ORIGIN DATE ABSTRACT 1181 GEN JOURNAL VINYL CHLORIOE INDUCED LIVER DISEASE THOMAS LB*NCIPOPPER H,NONE!BERK PDtNONESSELIKOFF I,NONE! FALK HyNONE! NONE,VOL 292 NO.li 1975* HISTOLOGIC EXAMINATION OF LIVER TISSUE (EIGHT AUTOPSY AND 16 BIOPSY SPECIMENS) AM) FIVE SPLEENS FROM 20 WORKERS WITH VINYL CHLORIDE POLYMERIZATION SHOWED HEPATIC ANGIOSARCOMAS IN 15. IN ADDITION* A PECULIAR PATTERN OF PROGRESSIVE PORTAL-TRACT,INCONSPICUOUS INTRALOBULAR AND CONSPICUOUS CAPSULAR FIBROSIS HAS OBSERVED IN THE FIVE WORKERS WITHOUT ANGIOSARCOMA, IN ALL THE SEVEN PATIENTS HITH ANGIOSARCOMA FROM WHOM TUMOR-FREE PORTIONS OF THE LIVER HERE AVAILABLE, 1 AND IN TWO TUMOR-FREE BIOPSIES FROM PATIENTS SUBSEQUENTLY FOLK) TO HAVE ANGIOSARCOMA. THE FIBROSIS HAS ACCOMPANIED BY SPLENOMEGALY. HYPERTROPHY AND HYPERPLASIA OF BOTH HEPAT0CYTE3 AND HEPATIC AND SPLENIC MESENCHYMAL CELLS HERE ALSO SEEN. THE HISTOLOGIC SIMILARITY TO CHRONIC INORGANIC ARSENICAL POISONING, IN NHICH ANGIOSARCOMAS ALSO OCCUR* AND fB XDXO- PATHIC PORTAL HYPERTENSION (BANTI'S SYNDROME) SUGGESTS THAT THE LATTER SYHDROME AT TIMES RESULTS FROM UNKOMt TOXIC* POSSIBLY ENVIRONMENTAL* CHEMICALS. "V it , m rtrY ipfr*? PRINTOUT for 6ART JONES ORDER NUMBER 66QSE7-135CS9-NIZ -001-00! rv PAGE 01 SET 4 WITH SOS OP DESCRIPTORS kwhhhNi ANGIOSARCOMA! HELD TERMS r\- KHIC INDEX NUMBER HEPATOTOXICITrt 00361PUBL REVIEW YEAH 1991 ; ACCESSION NUMBER 1174 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION TOXICITY STUDY EXPERIMENTS ON THE CHRONIC TOXICITY OF A COPOLYMER OF VINYL AND VINYUDINE CHLORIDE SEELER AOtHARVARO UNlVSCUNTON H, SAME i BOGGS J,SAMEI DRINKER PtSAMES ORIGIN HARVARO UNIV DATE ABSTRACT 1947 RATS FED A DIET CONTAINING S'/. VINYL AND VINYLIDINE CHLORIDE COPOLYMER FOR TWO YEARS SHOWED NO TOXIC EFFECTS. TWO DOGS MERE FED A DIET CONTAINING SX VINYL AND VINYLIDINE CHLORIDE COPOLYMER FOR TWO YEARS WITHOUT EVIDENCE OF TOXIC EFFECTS. DESCRIPTORS ******* pvc; vcm; chronic; carcinogenicity; rats; dogs; oral; * HELD TERMS DIETSVINYLIDINE CHLORIDE; ,,S KMIC INDEX NUMBER 00353TOXS REVIEW YEAR 1995 ^ flTEM 230 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ******* HELD TERMS KMIC INDEX NUMBER REVIEW YEAR 113S GEN > JOURNAL INDUSTRY'S LATEST CANCER SCARE NONE.none; NONE 1974. FEBRUARY liver; angiosarcoma; pvc; vinyl chloride; vinyudene chloride; BUSINESS week; 00315PUBL 1990 ITEM 231 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ******* HELD TERMS KMIC INDEX NUMBER REVIEW YEAR 1137 GEN JOURNAL PROPERTIES AND ESSENTIAL INFORMATION FOR SAFE HANDLING AND USE OF VINYL CHLORIDE none.none; 'v- NONE < 1972 VINYL CHLORIDES YOXICITY DATA; LIVERS MCA; + 1C .. . 00314PUBL ' -,`.i ;.\-V 1990 ' ' %' .. 899082',. 5^" -n- r f;' > i* 7 C" 'Oov sy rrrnrntiT top gapy ionfs am<XMEXmrOWmO->O<n>MCH-HCiHO5-rHTirIOn> Mnon--aM mmaxg^wc3niHoi m "o 0(t1l OU1 ZW M> S'" H'00O3H>5<Ah>0a0C5O1r,n09>^ OOUHWZ'OIISI# ootfgr r>zu3i>w nranmxznmznz* chw hi a i-- P^ inom am m2 c/i g m r hi a 5 Soh O Q c# n sis S r_ H<oeoSaxeH<nHoiO*atiMZm>-e430nZnoiM^j 52 53 a a. ISSzz *m -< n mha a cM f>f- > " :S- ` .V'. ;.' ^ 'jr Hf-i'5 r'-'-'r. y 'Hi V*. h'- '- " - M O 03 CO "-s* o C3 q5^.% -v :'v-, .-j PRINTOUT FOR BART JONES ORDER NUMBER 660627-135259-NXZ -OQl-OOisM PARE 63 BET 4 NITW 365 OF 365`XTEMS , V OI-2-ETHYIHEXYL PHTHAUtEtDEPH)AhC 07NER>WmAU^- tSTIRS AUTHOR/AFFILIATION LAURENCE HHNONE;MAUKH,NCNe;TURNM^,l|S ORIGIN ENVIRONMEm-AL RESEARCH. DATE . 197S* ;,5, ,, jL &$L J. M; DESCRIPTORS ******* TOXICITY DATA} LDSOl PLAlTltlZERSl 'RVC} HELD TERMS UNIV OF TENNESSEE} BISteltKjXtfTHYL BUTY LCARBOBUTOXYMETHYL PHTHAUTEJ KMC INDEX NUMBER 00075PUBL - REVIEU YEAR 1990 ITEM 236 ACCESSION NUMBER 946 FILE LOCATION GEN DOCUMENT TYPE COMPANY CORR TITLE OR SUBJECT TOXICOLOGICAL INVESTIGATION OF VAZO 33 VINYL POLYMERIZATION CATALYST E,'-AZ0BI3(2 4-DIMETHYL-4-METH0XYVALER0NITRILE) AUTHOR/AFFILIATION FLETCHER CH,DUPONT! ORIGIN OUPONT, DATE 1974, FEBRUARY 26 DESCRIPTORS ******* TOXICITY DATAEFFECTS {DOSE! PVCJ HELD TERHS VAZO 33;AZOBIS-DIMETHYL-METHOXYVALERONITRILEI KWIC INDEX NUMBER 00070CORR REVIEW YEAR 1990 ITEM 237 ACCESSION NUMBER 932 FILE LOCATION GEN DOCUMENT TYPE TECHNICAL REPORT TITLE OR SUBJECT OCTYLTIN DATA REPORT AUTHOR/AFFILIATION NONE,NONE; ORIGIN MAT CHEMICALS DATE 1966, APRIL 19 ABSTRACT EXTRACTION PROCEDURE AM) RESULTS. PREPARATION OF PVC SPECIMENS FOR THE MAJOR PHYSICAL TEST. STANOARD TEST METHOD - XIX-SCA-1. CHEMICAL DATA REQUIRED FOR EVALUATION OF FOOD PACKAGING MATERIALS UWER THE FOOD ADDITIVES AMENDMENT. DESCRIPTORS ******* THERM0LlTE-63i;THERM0LITE-613;EXTRACTI0N test;fooo adoitive; VINYL RESINS; PVC3TIN compounds; KWIC INDEX NUMBER 00048REPO REVIEU YEAR 1990 Item 236 ACCESSION NUMBER 'FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE 931 gen -v \v-* , : . <- JOURNAL ONCOGENIC RESPONSE OF RAT SKIN LUNGS AND BONES TO VINYL CHLORIDE CAPUTO A,NONEiBIGOTTI A,SAME?VIOLA PL.SAME! Vjjk : . ' CANCER RESEARCH,VOL 31 PP.516-522; > . - -T v 1971, MAY 'r- Y> PI'THTMUT FOR GARY JOMFS A bp ; VJ.lv" 208S808T> PRINTOUT FOR GARYJOWES ^ ORDER NUMBER 660627-135259-HIZ -001-001 .X PAGE 64 SET 4 MITH 505 OF 365 ITEMS X ' ^^5 ABSTRACT DESCRIPTORS ***** HELD TERMS KWIC INDEX NUMBER REVIEW YEAR RATS CAR/IRE HISTAR STRAIN)"EXPOSED FOR IE MONTHS TO VAPORS OP VCHC3O,OO0PFM) DEVELOPED TUMORS ' OF THE SKIN.LUNGS AND BONES. THE CUTANEOUS TUMORS* M1ICH ALWAYS APPEARED IN THE AREA; IN WHICH SUBMAXILLARY AND PAROTID -GLANDS ARE LOCATED HAVE: BEEN kLLY RECOGNIZED AS.iSPIOEHHOID CARCINOMAS * PAPILLOMAS, AND MMCOEPIOERMOIQ CARCINOMAS. )L06ICAL CHARACTERISTICS OF LUNG TUMORS, WHICH OCCURED IN A LONER PERCENTAGE, HERS MAINLY EXCEPTION OF A SINGLE EPlOERMblD TUMOR ORIGINATING FROH wlENOCARCIHOMA TVPELi^ITH.THE .. ..(EhaL COVERING CELl&XN A HltJQR NUMBER OF RATS, A URGE PROLIFERATION OF CARTIUGINOUS TISSUE [AGNOSED AS OSTEOCHCMMOMA DEVELOPED IN THE METACARPAL AND METATARSAL REGIONS OF THE fOUft' iS. < * ' *' VCM; INHALATION; rats; CARCINOGENICITY) EFFECTS) CHRONIC) REGINA ELENA INSTITUTE FOR CANCER (ITALY)) 00047PUBL 1990 ITEM 239 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ******* KWIC INDEX NUMBER REVIEW YEAR 922 GEN JOURNAL HEALTH HAZARD EVALUATION/ TOXICITY DETERMINATION POLAKOFF PL, NONE,NONE) NONE 1973, PVC; MEAT-WRAPPERS ASTHMA; PYROLYSIS) 00036PUBL 1990 *XTEM 240 ACCESSION NUMBER 6B9 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT THE CORRELATION OF CLINICAL AND ENVIRONMENTAL MEASUREMENTS FOR WORKERS EXPOSED TO VINYL CHLORIDE AUTHOR/AFFILIATION KRAMER CG,DOHCHEMICAL C05MUTCHLER JE.SAME) ORIGIN AXHAtVOL 33NO.l PP.19-30} DATE 1972, JANUARY ABSTRACT A METHOD 19 DESCRIBED FOR THE STATISTICAL CONSOLIDATION AND CORRELATION OF ENVIRONMENTAL MEASUREMENTS AND CLINICAL FINDINGS USING AS AN EXAMPLE A GROUP OF HEALTHY MALE WORKERS EXPOSED ROUTINELY TO VINYL CHLORIDE FOR PERIODS UP TO 25 YEARS. RETROSPECTIVE IN NATURE THE STUDY REVEALS SEVERAL STATISICALLY SIGNIFICANT EFFECTS FROM CHRONIC EXPOSURES TO VINYL CHLORIDE AND TRACES OF VINYLIDENE CHLORIDE. DESCRIPTORS ******* VINYL CHLORIDE.WORKERS{EXPOSURE5 VINYLIDENE CHLORIDE{CHRONICS EFFECTS; REVIEW YEAR 1990 ,ITEH 241 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 66 GEN PUBLICATION LIFESPAN ORAL TOXICITY STUDY OF VINYL CHLORIDE IN RATS FERON VJ.NONESHENDRIKSEN CFM.NONE;SPEEK AJ,NONE)TIL HP,NONES SPIT BJ,NONES I Kv( IPM PRINTOUT FOR GARY JONES, ORDER NUMBER B60887-135259-MK -OOI^C ^ PA6E 05 SET 4 HITH SBS Of^3* ORIGIN NONE*VOL 1 DATE ^ ABSTRACT , 1W* JUNE ... .. ...... THE PRESENT 8TU^3fMME0utHA$^ORALLY ADMINISTERED VCH "NO-OBSERVEO-ABKRSE'EFFECT t|WELn IN RATS HAS RIGOROUS CONDITIONS OF CONTIHgOUS ORAL VCMEXP DESCRIPTORS HELD TERMS' REVIEW TEAR PONDER PRESENT IN THE 6ASTRD-- INTESTINAL TRACT*' ****** * oral;pvc$vcm;rats;carcinogenidiet; FOOD .AND COSMETICS TOXICOLOGY! 1990 Itehea* ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HEU) TERMS REVIEW YEAR 687 GEN REPORT LIFESPAN ORAL CARCINOGENICITY S1$0Y OF VINYL CHLORIDE IN RATS (FINAL REPORT) TIL HP,NONE;iMMEL HR *NONEFERQtftpVJfNONE! NONE,REPORT NO.V83.285/291D9S 1983, SEPTEMBER IT MAS CONCLUDED THAT UNDE# THE CONDITIONS OF THE PRESENT EXPERIMENT: VCM AT A LEVEL OF 1.3 MG/KG BODY HEIGHT/DAY INDUCES NEOPLASTIC AND NON-NEOPLASTIC CHANGES IN THE LIVER OF PATS) VCM AT A LEVEL OF 0.13 MG/KG BODY WEIGHT/DAY MAY LEAD TO MORE FEMALE RATS BEARING FOCI OF CELLULAR ALTERATION IN THE L|VER5 VCM AT LEVELS OF 0.014 OR 0.13 MG/KG BOOT HEIGHT/DAY HAY RESULT IN AN INCREASED INCIOENCfFOF BASOPHILIC FOCI OF CELLULAR ALTERATION IN THE LIVER OF FEMALE RATSJ0.13MG VCM/KG BODY HEIGHT/ DAY IS A "NO-OBSERVED-ADVERSE-EFFECT-LEVEL" WITH RESPECT TO THE INDUCTION OF TUMOURS IN RATS; pvc;vcm;oral;feeding stuoy;rats;cancer;chronic!Effects!OXETI DIETARY ADHINISTRATIONJCIVO INSTITUTES TNOJ > 1990 V * ITEM 243 ACCESSION NUMBER 649 FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT 2-PROPENOIC ACID, METHYL ESTER, POLYMER KITH CHLOROETHEKE (CAS* 25035-98-7): BFG TSCA INVENTORY SUBMISSION, FORMS B21463724, LOUISVILLE. AUTHOR/AFFILIATION NONE,NONE) ORIGIN BFG-CHEMICAL, TO EPA5 DATE 1976 ABSTRACT TSCA INVENTORY SUBMISSION OF CION 351 AND 576. DOCUMENT IN CHEN GROUP ENVIRON AFFAIRS DEPT FILES. DESCRIPTORS ******* CAS.N0.25035-9B-7;TSCA INVENTORY!GEON 351!GEON 576! METHYL ACRYLATE,VINYL CHLORIDE POLYMER .REVIEM YEAR 1990 ITEM 244 n A\ , *' ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE 848 GEN REPORT K>H ty rt`i!M'inr rnr> r*f)y inur* DATE S 0> 3* 23 H O Tl > HOMO m o r* n rmc3m m i-- n(tAn OZOk SHO>Oz 9M n 5z wo ni mn am w>j Gi z -a m tj z w i m o> 30 o Tm<O m 3 Sm om (OA toH 3*oW* Ha>m Ho3o o -n OM gOmr- o(A o>H Cl z "ma oO m m >O n r- n mm m r o' *5o n sgH Z OM > O' -< * m T1 M Sddz > a U1 ZOM -no m WHH f 5siM >m n HH 65 m * d3 3a z 1976 3 B BFG527V PRINTOUT FOR 8ARY ORDER NUMBER 860027-133259-WIZ *091- PA6E 07 SET A WITH 365 DP-,36* ABSTRACT DESCRIPTORS O' REVIEW TEAR ITEM 240 TSCA INVENTORY*.: CAS.N0.30S98*666 1990 " j vi`ct ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ****** REVIEW YEAR ITEM 249 732 GEN REPORT 2-PROPENOIC ACIO ETHYL ESTER* POLYMER WITH CHI SUBMISSION* FORMS B214637E4* LOUISVILLE. NONE,NONE; & BFG-CHEHICAL* TO EPA{ V 1970 TSCA INVENTORY SUBMISSION OF GEONS 352* 354* 500X12* 500X119* 560X83* 560X52* 580X158* GEON 580X135. DOCUMENT IN CHEM GROUP ENVIRON AFFAIRS DEPT FILES. CAS.NO.5035-97-6,TSCA INVENTORY*GEON 352IGEON 354{6E0N 560X12S6EON 560X63SGE0N 500X119i6EON 580X150; GEON 560X52IGE0N 580X13SJETHYL ACRYLATE* VC POLYMER 1990 s . : -V. ' * 'PT ' ' ; -K , <} ' : ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ****** REVIEW YEAR 731 ' ^ ' -i p1 l: GEN *' r' REPORT , 2-PROPENOIC ACID* ETHYL ESTER* POLYMER WITH CHLOROETHENE ICi*# 25033-97-8 It BF6 TSCA INVENTORY SUBMISSION, FORMS B21463732* AVON LAKE. 1^ none.none; * f' BFG-CHEMICAL, TO EPA; 1978 >V TSCA INVENTORY SUBMISSION OF GEONS 352* 354*500X12* 580X119,500X135, 560X150* GEON 560X83* GEON 580X52. DOCUMENT IN CHEM GROUP ENVIRON AFFAIRS DEPT FILES. CAS.NO.25035-97-6;TSCA INVENTORY;GEON 352;GE0N 354;6E0N 580X12{GEON 560X119;GEON 580X135JGE0N 580X150; GEON 580X52{GEON 580X03{ETHYL ACRYLATE* VC POLYMER 1990 &TEN 250 ACCESSION NUMBER 725 FILE LOCATION GEN DOCUMENT TYPE PAPER TITLE OR SUBJECT WORKING CONDITIONS AND MEASURES FOR THEIR SANITATION IN THE FftODUCTION AND UTILIZATION OF VINYL AUTHOR/AFFILIATION CHLORIDE PLASTICS '~ tribukh sl,none;tikhomirova np,none;levin sv,NONEtKOZLOV^LAIHONEt ^ `origin NONE,VOL 10 PP.38-45; DATE 1949 v% DESCRIPTORS ******* VCM{TOXICITY S PVC * PCS1S{ / l HELD TERMS HEPATITISSARG SANZT; rr REVIEW YEAR 1990 .' * f't' T11 IT Ff'P RARY 1nHF` rf)r*>nor<-% PRINTOUT FOR 6ART JONES ORDER NUMBER 860827-135259-MIZ -001-001 , PAGE 68 SET 4 WITH 365 OF 165 ITEMS : ' ITEM 251 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS **#** REVIEW YEAR 723 GEN JOURNAL THE EFFECT OI^EPEATED VtNYL CHLORIDE EXPOSURE ON RAT DU JT.NONEJTSENG HtNONE)TAMBURRO CHiUNIV OF LOUISVILLE? TOX AND APPLIED*VOL 62 PP.1-10; 1982, VCMiHETABO LISM X**0 ABOliziNB ENZYMES ITEM 252 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AF FILIATION ORIGIN OATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 721 GEN PUBLICATION TEN CANADIAN CASES OF ANGIOSARCOMA OF THE LIVER IH VINYL CHLORIDE WORKERS DELORME F'NONE; NONE.VOL 23 NO.2PP.97-103* ' 1978 TEN CASES OF ANGIOSARCOMA OF THE LIVER AMONG VtNYL CHLORIDE WORKERS FROM A PLANT IN SHAMIN1GAN* QUEBEC. ARE REPORTED, THE AUTHOR INSIST MOSTLY OH THE OCCUPATIONAL HISTORY OF THESE WORKERS AND ON THE MORPHOLOGIC DESCRIPTION OF THE LESIONS. A PATHOGENIC HYPOTHESIS IS SUBMITTED. VCM;ANGIOSARCOMA;HUMAN;EFFECTSLIVER ANNALES D'ANATOMIC PATHOLOGIQUEi 1990 ITEM 253 ACCESSION NUMBER 716 FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT 2-PROPENOIC ACIO* POLYMER KITH CHLOROETHENE AMI METHYL 2-PROPENOATE (CASS 28572-90-9): BFG TSCA INVENTORY SUBMISSION. FORMS B21463732* AVON LAKE. AUTHOR/AFFILIATION NONE.NOME) ORIGIN BFG-CHEMICAL. TO EPA{ DATE 1978 ABSTRACT TSCA INVENTORY SUBMISSION OF GEON 460X7. DOCUMENT IH CHEN GROUP ENVIRON AFFAIRS DEPT FILES. DESCRIPTORS **** CAS.NO.26572-90-9.TSCA INVENTORY{GEON 460X7} AA.VC.METHYL ACRYLATE POLYMER REVIEW YEAR 1990 .ITEM 254 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 715 GEN ? REPORT 2-PROPENOIC ACID* POLYMER WITH CHLOROETHENE* N-(HYDROXYMETHYL1-S-PROPENAMIDE AND METHYL 2-PROPENOATE (CASS 65045-75-2): BFG TSCA INVENTORY SUBMISSION* FORMS B21463732* AVON LAKE. 20838089 rp P I 2 338090 PRINTOUT FOR GARY JONES h ORDER NUMBER B60627-135259-WIZ -001-00 r-- PAGE 69 SET 6 WITH 365 OF AUTHQR/AFFILIATXON ' NONE*NONE} ORIGIN . BFG-CHENICAL# TO IW nil DATE 1976 .. >.Js. ABSTRACT TSCA INVENTORY*1I FILES. -v. . . , -. , `TM' 1 / *' DESCRIPTORS wmnum CA5.NO.65045-7S-8)TSCA SNVEHHMYSGEOH BtflptSI POLYMER -vto REVIEW YEAR 1990 ITEM 255 w* % ACCESSION NUMBER 714 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT REPORT 2-PROPENOIC ACIO, POLYMER WITH CHLOROETHENE, ETHYL 8-PROPENOATE* N-(HYDR0XYMETHYL)-2~PR0PENAMIDE AND 2-PROPENENITRILE (CAS* 35743-23-6): BF6 TSCA INVENTORY SUBMISSION* FORM* B2146450S* AVON LAKE. >. : AUTHOR/AFFILIATION NONEtNONE* ORIGIN BFG-CHEMICAL* TO EPA) DATE ABSTRACT 1976 TSCA INVENTORY SUBMISSION OF 6E0N 460X1. DOCUMENT IN CHEM GROUP ENVIRON AFFAIRS DEPT FILES. DESCRIPTORS whhhhi* CAS.NO.35743-23-6*TSCA INVENTORYI6E0N 460X1) AAVC*EAN-(HM)ACRYLAMIDEACRYLONITRILE POLYMER REVIEW YEAR 1990 : t:, ITEH 256 ACCESSION NUMBER FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT 2-PROPENOIC ACID* POLYMER WITH CHLOROETHENE* ETHYL 2-PROPEHOATE AND N-(HYDROXYMETHYL1-2-PROPENAMIDE (CAS* 35743-21-6): BP6 TSCA INVENTORY SUBMISSION* FORM* B21463732* AVON LAKE. AUTHOR/AFFILIATION NONE.NONE) ,.r ORIGIN BFG-CHEMICAL* TO EPA; DATE 1978 ABSTRACT TSCA INVENTORY SUBMISSION OF GEON 460X9. DOCUMENT IN CHEM GROUP ENVIRON AFFAIRS DEPT FILES. DESCRIPTORS ####*# CAS.N0.35743-21-6JTSCA INVENTORY* GEON 460X9) AAVC,EA,N-IHH)ACRYLAMIDE POLYMER REVIEW YEAR 1990 flTEh 257 ACCESSION NUMBER FILE LOCATION --DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT PAPER VINYL CHLORIDE CONTENT OF SIOCUTANEOUS ADIPOSE TISSUE FROM VINYL CHLORIDE POLYMERIZATION WORKERS KNITTLE JL.NEN YORK (JNIV)FONTANARES PSAME)DAUM S.SAME) SCL1KOFF IJ,SAME) NONE>none; ; 1974 SIGNIFICANT LEVELS OF VINYL CHLORIDE MONOMER WE|tE FOUND IN SUBCUTANEOUS FAT DEPOTS OF WORKERS EXPOSED TO THE GAS DURING THE MANUFACTURE OF POLYVINYL CHLORIDE. THE COMPOUND NAS NOT DETECTED IN *<- l"irnioiiT FOT r-APY !niir? *: . J BFG52779 printout ran sart JoNes ORDER NUMBER 660627-135259-WIZ -001-001 PAGE 90 SET 9 WITH 365 OP 365 ITtMS DESCRIPTORS HELD TERI1S REVIEW YEAR A CONTROL GROUP OP UNEXPOSED WORKERS Hwmut vcm;adiposehumans;effects BIOACCUMULATORSDEPOSITION} 1990 *` O'* ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR ; 'V 711 ............... GEN PUBLICATION HEMANGIOSARCOMA AND HEPATOCELLULAR CARCINOMA OP THE LIVER FOLLOWING VINTL CHLORIDE EXPOSURE GOKEL JMiNONES LIEBEZEIT E.NONESEDER MtNONES - NONE *VOL 372 NO.3 PP.195-203} 1976 A REPORT IS GIVEN OF THE CLINICAL AND AUTOPSY FINDINGS OP TWO MEN WO DIED FROM MALIGNANT LIVER NEOPLASM FOLLOWING OCCUPATIONAL EXPOSURE TO VINTL CHLORIOE. THE FIRST PATIENT NAS A 44-YEAR-OLO MAN WITH AN HEMANGIOSARCOMA OF THE LIVER* THE SECOND PATIENT A 67-YEAR-OLD MAN WITH AN HEPATOCELLULAR CARCINOMA. SO FAR AN HEPATOCELLULAR CARCINOMA DUE TO VINYL CHLORIDE HAS NOT YET BEEN OBSERVED IN MAN. ITS OCCURRENCE* HOWEVER* HAS BEEN SUGGESTED FROM THE RESULTS OF ANIMAL EXPERIMENTS. THE CONNECTION OF HEPATOCELLULAR CARCINOMA MHH EXPOSURE TO VINYL CHLORIDE IS DISCUSSED. ',, VCM}ANGIOSARCOMA}LIVERSCANCERSHUMANS}EFFECTS} HEPATOCELLULAR CARCINCMASVIRCHOW ARCH PATH ANATS - 1990 l: ;? '>'* ITEM 259 ACCESSION NUMBER FILE LOCATION OOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ****** REVIEW YEAR 710 GEN BIBLIOGRAWY LIVER ANGIOSARt ES (ALL KNOW CASES UP TO JANUARY>1965> NONE*NONES ICI 1966* JANUARY THIS OOCUMENT IS A REVIEW OF ALL ANGIOSARCOMA DEATHS IN PEOPLE WO HAVE BEEN EMPLOYED IN A VCM/PVC FACILITY. IT IS UPDATED APPROXIMATELY BI-ANNUALLY. VCM;ANGIOSARCOMASHUMANS}EFFECTS 1967 4 ITEM 260 ACCESSION NUMBER FILE LOCATION .DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE 709 GEN REPORT 2-PROPENOXC ACIO* POLYMER WITH CHLOROETHENE* ETHENYLBENZEWf ETHYL 2-PROPENOATE AND N-(HYDROXYMETHYLJ-2-PROPENAMID6 (CAS# 65045-77-41* BFG TSCA INVENTORY SUBMISSION* FORM* 821464490* AVON LAKE. mt. NONE*NONES BFG-CHEMICAL* TO EPA* '.f s 197B X. BFG52180 20898091: PRINTOUT FOR GARY,JONES OROER NUMBER 860827-135259-WIZ , -OOl-OOl PAGE 91 BET * MITH 385 OF 38t:tTEHS.l, ABSTRACT DESCRIPTORS REVIEW TEAR ITEM 261 ' TSCA ` INVENT^'' WHHHHHI CAS.NO.65045* . 1990 - . _ 6-.: ACCESSION NUMBER 708 FILE LOCATION BEN DOCUMENT TYPE TITLE OR SUBJECT REPORT 2-PROPENOIC ACID* POLYMER MITH CHLOROETHENE* ETHENYL ACETATE. AND N-( HYDROXYMETHYLJ-2-WOPENAMIDE (CAS* 40311-70-4): BFG TSCA INVENTORY SUBMISSION* FORM* B21464292, AVON LAKE* AIJTHOR/AFFILIATION NONE,none; ORIGIN BFG-CHEMICAL* TO EPAJ DATE 1978 ABSTRACT TSCA INVENTORY SUBMISSION OF GEON 590X6. DOCUMENT IN CHEM GROUP ENVIRON AFFAIRS DEPT FILES. DESCRIPTORS ******* CAS.NO.40311-70-4?TSCA INVENTORYJGEON 590X61 AA*VC,EA*N-HM-2-PA POLYMER REVIEW YEAR 1990 ITEM 262 ACCESSION NUMBER FILE LOCATION 707 GEN < ' ' DOCUMENT TYPE REPORT TITLE OR SUBJECT 2-PROPENOIC ACIDi POLYMER WITH CHLOROETHENE AND ETHENYL ACETATE (CASS E903B-S1-EH BFG TSCA INVENTORY SUBMISSION* FRONS B21463732, AVON LAKE. AUTHOR/AFFILIATION ORIGIN NONE.NONE? ' *=i " BFG-CHEMICAL, TO EPAJ ' DATE 1978 ABSTRACT TSCA INVENTORY SUBMISSION OF GEON 460X6. DOCUMENT IN CHEM GROUP ENVIRON AFFAIRS DEPT FILES. DESCRIPTORS ******* CAS.NO.29035-81-2;TSCA INVENTORY;GEON 460X61 ACRYLIC ACIOtViNTL CHLORIDE,ETHENYL ACETATE POLYMER REVIEW YEAR 1990 : Item 263 ACCESSION NUMBER 706 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT ASSOCIATION OF AN ANGIOSARCOMA OF THE LIVER WITH A HEPATOMA IN A VINYL CHLORIDE WORKER AUTHOR/AFFILIATION DELORME F.NONE; ORIGIN NONE,VOL 23 NO.2 PP.105-114; DATE 1978 ABSTRACT THIS REPORT DEALS WITH A 51 YEARS-OLD MAN WHO* FOR 23 YEARS AM) 4 MONTHS OF HIS WORKING LIFE* HAD BEEN EXPOSED TO VINYL CHLORIDE VAPORS. AUTOPSY REVEALED A HEPATOMA ASSOCIATED WITH AN ANGIOSARCOMA OF THE LIVER. THE CASE IS THE FIRST EVER TO BE REPORTEO IN THE MEDICAL LITERATURE,! THIS CASE RAISES DOUBT ABOUT THE THEORY WHICH SUGGESTS TTtAf: iHt CARCINOGENIC EFFECT OF VINYL DESCRIPTORS HELO TERMS REVIEW YEAR CHLORIDE IN MAN ELICIT A TUMOR OF VASCULAR NATURES #**** vcm;angiosarcona;huhans{ffects;lxver ANALES D'ANATOHIE PATHOLOGIQUE * 1990 * wSfa i s> ' rnnipMiT rw cary .iomfs ' V-'V 20838093 BFG52782 PRINTOUT FOR GARY JONES -M, ORDER HUMBER B60627-13S259-MIZ -QOl-OOl PAGE 92 SET 4 WITH 365 OF 365 ITEMS ITEM 264 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 705 GEN REPORT 2-PROPENOIC ACID* POLYMER WITH CHLOROETHENE. l.t^OICHLOROETMOte AND 2-ETHYLHE^L 4-NS<>PENOATE (CAS# 65045-76-3) BF6 TSCA INVENTORY SUBMISSION*; FORMS B21464490* AVON LAKE. ' AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ** NONE.none; BFG-CHEMICAL, TO EPA? 1976 TSCA INVENTORY SUBMISSION OF GEON 450X20. DOCUMENT IN CHEM GROUP ENVIRON AFFAIRS DEPT FILES. CAS.N0.65045-76-3;TSCA INVENTORY;GEON 450X201 AA*VC,1,1-DCE.2-EH 2-P POLYMER REVIEW YEAR 1990 ITEM 265 ACCESSION NUMBER 704 FILE LOCATION GEN OOCUMENT TYPE PUBLICATION TITLE OR SUBJECT SCLERODERMA LIKE SKIN CHANGES. RAYNAUD * S SYNDROME AND ACROOSTEOLYSES IN WORKERS IN THE POLYVINYL CHLORIDE PRODUCING INDUSTRY AUTHOR/AFFILIATION JUHE S.NONE!LANGE ce.none; ORIGIN NONE.VOL 97 PP.1922-1923? DATE 1972 DESCRIPTORS ### vcm;aol;syndrome HELD TERMS SCLERODERMASOTSCH MED HSCHR? REVIEW YEAR 1990 ITEM 266 ACCESSION NUMBER 703 ' FILE LOCATION DOCUMENT TYPE SEN PUBLICATION TITLE OR SUBJECT TOXIC TRIGEMINAL DISEASE AND POLYVINTLIDENE CHLORIDE AUTHOR/AFFILIATION KRIEGER JNONE5HARTER JM.NONESMENGUS M.NONEiMEHL J.NONESISCH F.NONEI ORIGIN NONE.VOL 43 PP.64-66? DATE 1971 DESCRIPTORS ** VCMJAOlJHUMANSJEFFECTS HELD TERMS REVUE D'OTO-NEURO-OPHTALMOLOGIE5 REVIEW YEAR 1990 Item 267 "ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION V 702 GEN PAPER OCCUPATIONAL ACROOSTEOLYSIS (AOL)= AN EPIDEMIOLOGIC INVESTIGATION OF A NEH DISEASE AMONG POLYVINYL CHLORI0E SYNTHESIS WORKERS MAGNUSON JiNONE.DINMAN BONONE?COOK HA.HONEf6IEVER PH.NONEtilWtTEHOUSE HM.MONE? 20838093 & I PRINTOUT POT GARY JQNU ORDER NUtBER 660827-1352S9-HIZ 0 -OQl-QOl PAGE 93 SET 4 WITH MI0F S8I ORIGIN DATE 1* N0NE*PP.*21JhUC#' 1969, SEPTEMBER 2-27 ^ DESCRIPTORS HELD TERMS REVIEW YEAR VCMiAOUHUMANStEFFEi INTERNATIONA^ 1990 - : ACCESSION NlftCER PILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR |mtt e69 p ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 270 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 701 GEN PUBLICATION OCCUPATIONAL ACROOSTEOLYSIS MARKOWITZ SSjNONEJMC DONA10 CJ,SAME(FETHIERE MSAHESKERZNER M3iSA*( ARCH DERMATOL,VOL 106 PP.219-2235 1972, AUGUST OCCUPATIONAL ACROOSTEOLYSIS IS AN UNUSUAL DISEASE IN WHICH AFFECTED PERSONS HAVE SCLERODERMOID-LIKE LESIONS OF THE SKIN, CONDITIONS SIMILAR TO RAYNAUD'S PHENOMENON* AND ASYMPTOMATIC* BONY OEFECTS OF THE EXTREMITIES. TO OUR KNOWLEDGE, THE DISEASE IS CONFINED SOLELY TO WORKERS IN THE PLASTICS INDUSTRY* SPECIFICALLY THOSE ENGAGED IN THE PRODUCTION OF POLYVINYL CHLORIDE FROM VINYL CHLORIDE. THE INCIDENCE OF THE DISEASE IS UNKNOWN BUT IS THOUGHT. TO OCCUR IN 3X OR LESS OF WORKERS. ' 'i- a v. ' vcm;acroosteolysis;syndrone;huiunsseffecT3 ^ r'7 ' BROWN UNIV;RAYNAUD'S SYNDROME} 'V 1990 ** 697 ..... * * y / sV , , GEN r-t * n- -:f -p-;;K' PUBLICATION r. ,s t` - - . r; OCCUPATIONAL LESIONS OP THE SKIN DUE TO PVC sonneck hj.none; HONE,VOL 6 PP.36-931 * 1962 TWO CASES OF OCCUPATIONAL LESIONS OF THE SKIN OBSERVED IN THE INDUSTRY MAKING USE OF POLYVINYL CHLORIDES, ARE DEALT WITH. IN THE LIGHT OF TEST RESULTS IT IS SUPPOSED THAT A COMPLEXE TOXIC AND ALLERGIC MECHANISM PUTS A PART, THAT MEANS THAT THE EMULSIFIER WITH ITS STRONG DEGREASING PROPERTIES OR THE SOLVENTS USED MAY CAUSE NOT ONLY AN IRRITATIONS THE SKIN BUT MAY EVEN FURTHER A SENSIBILIZATION TO POLYVINYL CHLORIOE WHICH* GENERALLY, IS NOt CONSIDERED TO BE A SENSITIZER. VCM(SKIN*LESIONS(NORKERS(HUMAN*EFFECTSlSOLVENTS BERUFSDERMATOSEN, - 1990 ft 699 6EN JOURNAL OCCUPATIONAL ACROOSTEOLYSIS WILSON RH,BFG(MC COTMICK W6,SAMEjtatuh cf,none;eech JLN0Nk) X1 ip Is 'Tf.V i'",ifi*tt rn" r^nr tnnr -- ' t' PRINTOUT FOR BART JGNE* ORDER NUMBER 860627-135259-MIZ -001-001 , PAGE 94 SET 4 WITH 385 OP 385 ITEI1S VrV; ORIGIN DATE ABSTRACT DESCRIPTORS REVIEM YEAR JAMA,VOL EOI NO.S^P.i 1967, AUGUST 21 IN 31 CASES OF ACROOSTEOtTSI OF THE HANDS OP WORKMEN POLYMERIZATION PROCESSES* ./EOLYSIS IMS FREQUENTLY ASSOCIATED HI UJO-SSYHPttMS* TinHsE DvIiSiiOuRnDuEuRi IiaS BDEikLUIETVE^Du Wiu Hi RREtsSuULkTMEDV.FimROmM #&-),w AND PERSONAL IDIOSYNCRASY: THE SPECIFIC CAUSES ARE THAN 3Y. AMONG EMPLOYEES PERFORMING SIMILAR HORK- NO CASES PROCESSING THE POLYMER OR MANUFACTURING COMMERCIAL RESINS; ******* VCM;AOLHUMANEFFECTSiMORKERSIEPIDEMIOLOGY 1990 StiEH 271 VINYL CNLORXOf (CH2CNCLF SICAL INSULT; CHeHiCAL INSULT, EVALLncE HAS FOUNofoilLESS in norkmen UsiNR or rP i ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ****** HELD TERMS REVIEW YEAR 668 GEN PROCEEDINGS , OCCUPATIONAL CARCINOGENESIS ' MALTONI C,NONE; NONE,VOL 2 SERIES NO.322$ 1973, APRIL 9-12 OVERVIEW OF CHEMICAL CARCINOGENESIS AND ANIMAL STUDIES SHOWING VCH INDUCED CANCER OF THE LIVER (ANGIOSARCOMA) AND ZYMBAL GLAND. vcm;rats;angiosarcoma$zynbal gland;tumors;carcinogenicitt;inhalation) chronic;effects INTERNATIONAL CONGRESS ON OCCUPATIONAL HEALTH! 1990 >* ITEM 272 ACCESSION NUMBER FILE LOCATION OOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ****** REVIEW YEAR 687 GEN REPORT 2-PROPENOIC ACID, POLYMER WITH BUTYL 2-PROPENOATE, 1,1-DICHLOROETHENE AND N-(HYDROXYMETHYL1-2-PROPENAMIOE (CAS* 357433-24-9): BFG TSCA INVENTORY SUBMISSION, FORMS B21464490, AVON LAKE. NONE,hone; BFG-CHEMICAL, TO EPA$ 1978 TSCA INVENTORY SUBMISSION OF 6E0N5 660X1 AM) X4. OOCUMENT IN CHEM GROUP ENVIRON AFFAIRS DEPT FILES. CAS.NO.35743-24-9$TSCA INVENTORY$6E0N 660X1;6E0N 660X4$AA,B 2-P,l,i-DCE,N-HM-2-PA 1990 _JlTEM 273 ACCESSION NUMBER FILE LOCATION OOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 666 GEN JOURNAL ACUTE INHALATION TOXICITY OF VINYL CHLORIDE TO LABORATORY AHlHALS mastromatteo e,none;fisher am*none$christie h,none;danziger^HnoNe$ 20838095 A !"*11itniit rnn inirr- A: wm m J-L- 20oJ803S PRINTOUT FOR 6ART ORDER NUMBER B60627-135259-HIZ -OOl-ODt PA6C 90 SET 9 KITH 360 OF,Sflfc|M$ ORIGIN DATE ABSTRACT DESCRIPTORS REVIEW TEAR J OP AXHAtVOf^itffa^ I960 IRRITATION AND 10-40X IN MICERATS AHO VCMIINHALATIONsHXCEIRATG} 1990 * - ' 4*#* 879 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ****** HELD TERMS REVIEW YEAR 685 GEN PUBLICATION CHRONIC ORAL TOXICITY TO RATS OF A VINYL CHLORIDE-VINYL ACfcTJKTt tOPOLYMER SMYTH HF.NONESHEIL CS.SAMEJ TOX AND APPLIEDVOL 9 PP.501-504; 1966 STARTING IN 1944* ALBINO RATS OF BOTH SEXES CAGED TOGETHER HERE MAINTAINED FOR TWO YEARS UPON DIETS CONTAINING 1.5X AND 12X OF A VINYL CHLORIDE-VINYL ACETATE COPOLYMER. NO EFFECTS ATTRIBUTABLE TO THE RESIN WAS FOUND. "t> . PVCiVCMjVOC(CARCINOGENICITY{ORAL?RATS(CHRONIC{EFFECTS ' "& *** : DIET; MELLON INSTITUTE} 1990 ' * Item 275 V; .$: . fr. 'V > v , V- ' V -' 'Hv', .. ^ i ^ 1 1' v ~V- 'V : ACCESSION NUMBER 664 - *f>.**\* \ FILE LOCATION GEN i DOCUMENT TYPE PUBLICATION , . ,. TITLE OR SUBJECT ONE-YEAR TIME SEQUENCE INHALATION TOXICITY STUDY OF VINYL CNLoNlDE IN RATS* X. GROWTH. MORTALITY* HAEMATOLOGY. CLINICAL CHEMISTRY AND ORGAN HEIGHTS * -'K- AUTHOR/AFFILIATION FERON VJ.N0NE;KRUYSSE A.NONEITXL HP.NONE}V '* .* ORIGIN NONE,VOL 13 PP.25-26; lVv: DATE 1979 ABSTRACT WISTAR RATS HERE EXPOSED TO ATMOSPHERES CONTAINING 0 (CONTROL; OR 5000 PPM VINYL CHLORIDE MONOMER (VCM; 7 HR/DAY, 5 DAYS/WEEK, FOR A PERIOD OF 52 MEEKS. AFTER 4,13,26 AND 52 NEEKS EACH TIME 10 RATS/SEX/GROUP HERE KILLED ANO SUBJECTED TO EXTENSIVE EXAMINATIONS. THE PRESENT PAPER DEALS WITH GROWTH, MORTALITY, HAEMATOLOGY, CLINICAL CHEMISTRY AND ORGAN HEIGHTS. THE PRESENT STUDY OZD NOT PRODUCE OBVIOUSLY SUITABLE PARAMETERS FOR EARLY'DIAGNOSING "VCM-DISEASE" IN HAN. DESCRIPTORS II RHRAIrlf VCM;RATS;INHALATION;CHRONICDETERMINATION HELD TERMS diagnosis; toxicology; REVIEW TEAR 1990 ITEM 276 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN 683 > 6EN PUBLICATION ANESTHESIA XXVIIs NARCOSIS WITH VINYL CHLORIDE OSTER rh,none;carr cj.noneikrantz jc.nqne; NONE,VOL 6 PP.359-361} Tiff _ pH I'lrn'ir rnn rApy iomf*: 20^3*5037' PRINTOUT FOR 6ARY,JONES ORDER NUMBER 86O027-I35259-MIZ -OOl-Odl^ PAGE 96 SET 4 WITH 385 OP SSlnXTiHS . DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 1947. JULY NARCOSIS AND CARDIAC ARRHYTHMIA OBSERVED VCM;CARDIAC ARRHYTHMIAS ANESTHESIAS 1990 - ' J**j*tf ; .5 -k r.-r ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELO TERMS REVIEH YEAR 'ITEM 278 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 682 6EN PUBLICATION ONE-YEAR TIME-SEQUENCE INHALATION TOXICITY STUDY OF VINYL CHLORIDE IN RATS : II. MQRRfOLOGICAL CHANCES IN THE RESPIRATORY TRACTCERUMINOUS GLANDS* BRAIN,KIDNEYS,HEART AND SPLEEN, J FERON VJNONE;KROES R,NONEI NONE,VOL 13 PP.131-141; 1979 MISTAR RATS HERE EXPOSED TO ATMOSPHERES CONTAINING 0 (CONTROL) OR 5000 PPM VINYL CHLORIDE MONOMER (VCM), 7 HR/DAY, 5 DAYS/UEEK* FOR A PERIOD OF 52 WEEKS. AFTER 4,13,26 AND 52 MEEKS EACH TIME 10 RATS/ SEX /GROUP HERE KILLEO AND SUBJECTED TO EXTENSIVE EXAMINATIONS. THE PRESENT PAPER DESCRIBES THE MORPHOLOGICAL CHANGES OBSERVED IN THE RESPIRATORY TRACT* CERUMINOUS GLANDSBRAIN* KIONEYS,HEART AM) SPLEEN. THE VCM-EFFECTS INCLUDED INCREASED OEGREE OF TUBULAR NEPHROSIS* MILD FOCAL DEGENERATION OF THE MYOCARD, ANO INCREASED HAEMATOPOIETIC ACTIVITY IN THE SPLEEN. IN ADDITION* PRIMARY TUMOURS HERE FOUND IN THE BRAIN (EPENDYMOMA),LUNGS (PAPILLARY ADENOHA AND MESENCHYMAL TYPE OF TUMOUR), CERUMINOUS GLANDS (MAINLY KERATINIZEO SQUAMOUS CELL CARCINOMAS), ANO NASAL CAVITY (CARCXNOHAS OF THE OLFACTORY EPITHELIUM* CARCINO-SARCOMA,ESTHESIONEUROEPITHELIOMA). vcm;inhalation;rats;chronic;carcinogenicety;respiratory effects RESPIRATORY TRACT* TOXICOLOGY) 1990 681 GEN PUBLICATION ONE-YEAR TIME-SEQUENCE INHALATION TOXICITY STUOY OF VINYL CHLORIDE IN RATS: XII. MORPHOLOGICAL CHANGES IN THE LIVER feron vj,none;spit bj,none;xi*!EL hrnone;kroes r,none; NONE,VOL 13 PP.143-154; 1979 UISTAR RATS HERE EXPOSED TO ATMOSPHERES CONTAINING 0 (CONTROL) OR 5000 PPM VINYL CHLORIDE MONOMER (VCM), 7 HR/DAY, 5 DAYS/WEEK, FOR A PERIOD OF 52 HEEKS. AFTER 4*13,26,52 HEEK5 EACH TIME 10 RATS/SEX/ GROUP HERE KILLED AND SUBJECTED TO EXTENSIVE EXAMINATIONS. THE PRESENT PAPER DESCRIBES THE MORPHOLOGICAL CHANGES FOUND IN THE LIVER. THE MAJOR PARENCHYMAL CHANGES COMPRISED SWELLING AND MALFORMATION OF MITOCHONORIA, AN INCREASED AMOUNT OF SMOOTH ENDOPLASMIC RETICULUM, NECROSIS * MJCLEAR AND CELLULAR POLYMORPHISM OF HEPATOCYTES* "FOCI OF CELLULAR ALTERATION", NEOPLASTIC NODULES AND HEPATOCELLULAR CARCINOMAS. A REDUCED GLUCOSE -6-PHOSPHATASE ACTIVITY IN HEPATOCYTES AND A STRON SINUSOIDAL ACTIVITY OF ALKALINE PHOSPHATASE HERE FOUND HITHIN "FOCI OF CELLULAR ALTERATION". THE NON-PARENCHYMAL ALTERATIONS INCLUDED FOCAL DILATATION OF SINUSOIDS, FOCAL PROLIFERATION OF ATYPICAL SINUSOIDAL CELLS ANO HUltlCEKTRlC ANGIOSARCOMAS. IKE EFFECTS OF VCM ON THE HEPATIC PARENCHYMA SEEMED TO RECEDE THOSE ONTHEvflEPATlC STROMA. ' l "MMour rnp rupy inur** ' -V- PRINTOUT FOR GARY ORDER NUMBER 660S27-135259-MIZ -OOl-OOt PAGE 97 SET A WITH 385 OP SJUTXTEMft & DESCRIPTORS HELD TERMS REVIEW YEAR *** VCMlINHALATtONjllAtSI ,,-,v TOXICOLOGY^ " '%1998 JrJ v v^ ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT descriptors *** REVIEW YEAR 660 GEN JOURNAL S.if ' EFFECTS OF SINGLE AND REPEATED EXPOSURES OF HUMANS AM) RATS TO VINYL CHLORIDE LESTER D,N0NEi6REENBERG U,NONE5ADAMS NR,NONEt f J OF AIHAVOL 24 PP.265-1755 1963. MAY-JUNE if*-'' . RATS EXPOSED EIGHT HOURS DAILY TO VINYL CHLORIOE AT CONCENTRATIONS OF E vcm;rats;humans;xnhalation;subchronic 1990 ITEM 2B0 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATXON ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 679 6EN PUBLICATION NONNEOPLASTIC EFFECTS 0j L CHLORIDE IN HOUSE LUNG SUZUKI T.NEH YORK ENVIRONMENTAL RESEJ tlPP.235-2531 1960 IN A PREVIOUS sraff> A HIGH INCIDENCE OF PULMONARY TUMORS IALVEOLOGENIC NEOPLASIA IN MOUSE LUNG EXPOSED TO VINYtjfCHLORIOE AT HEAVY DOSE (2300 ANO 6000 PPM) FOR LONG DURATIONS (3 AND 6 MONTHS) NAS REPORTEO it: SUZUKI, 1978,ENVIRON.RES. 16,263-301). IN THE^PRESENT STUDY* NOWEOPUSTXC EFFECTS IN MOUSE LUNG HERE INVESTIGATED BY LIGHT ANO ELECTRON MICROSCOPY. VCM5INHALOl0N;HICE;LUNG;CARCIN0GENICITY|CHR0NlC)EFFECTS, ... CITY UNWOF NEW YORK) l$r- 1990 Jr . ITEM 261 ACCESSION NUMBER 678 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT AUTHOR/AFFILIATION INHALATION PHARMACOKINE1 BASED ON GAS UPTAKE STUDIES bolt hm,none;filser lEfBUCHTER A,NONE) ORIGIN NONE,VOL 48 PP.i OATE 1961 ABSTRACT AFTER COMPARING.JTt-HR EXPOSURE TO 5 PPM VCH WITH TWO 50 PPM VCM PEAKS FOR 5 MINUTES EACH IN THE RHESUS MONKEY, ttfc AUTHORS CONCLUDED THAT REGARDLESS OF THE EXPOSURE PROFILE THE AMOUNT OF REACTIVE METABOLITES FORMED FROM VCM WOULD SOLELY BE A FUNCTlbN OF MEAN VCM CONCENTRATION (AIR) OVERTIME. x DESCRIPTORS WJHHHHHt VCH 5 INKAP ON tFHARMACOKXNETZCStMETABOUSH (HpNKl HELD TERMS PEAR C ATXONStRHESUS MONKEY) ARCH,TOXICOL ' REVXEH YEAR 1990 a if ? , fninnnr rnn gapy iomf*. l. t v* PRINTOUT FOR GARY J<*fcS ORDER NUMBER 860627-135259-NIZ -ODl-ODl PAGE 98 SET 4 WITH 385 OF 385 ITEMS 20898039, ACCESSION NUMBER 677 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT PUBLICATION . PHARMACOKINETICS OF VINyL CHUJRIDE IN THE &AT _ AUTHOR/AFFILIATION BOLT HM.NONEiLAIB RJ,N0NE}KAPRU8 H,MONE}BUCHTER ORIGIN NONEVOL 7 PP.179-188} r DATE ABSTRACT 1977 .' PHARMACOKINETIC ANALYSIS SHOWS THAT NO SIGNIFICANT CUMUUTION OF VINYL CHLORIDE OR ITS MAJOR METABOLITES IS TO BE EXPECTED ON REPEATED ADMINISTRATION OF VINYL CHLORIDES. THIS MAY BE CONSISTENT WITH THE THEORY THAT A REACTIVE SHORTLY LIVING,METABOLITE NHICH OCCURS IN UM CONCENTRATION ONLY, MAY BE RESPONSIBLE FOR THE TOXIC EFFECTS OF VINYL CHLORIDE. DESCRIPTORS ******* VCH! PHARMACOKINETICS 5 METABOLISM J RAT} XMALATION HELD TERMS TOXICOLOGY5INSTITUTE OF TOXICOLOGYiUNIV OF TUBINGEN;INSTITUTE OF OCCUPATIONAL AND SOCIAL MEDICINEJUNIV OF COLOGNE; ' ; REVIEW YEAR 1990 . ' ftTEN 283 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 676 'V ** *'' GEN PUBLICATION ` DISPOSITION OF (1,2-14C> VINYL CHLORIDE IN RAT BOLT hm,none;kappus h,none;buchtep anone;bolt m,none; *' ^ ^ NONE,VOL 35 NO.3 PP.IS3-162; 1976 IMMEDIATELY AFTER EXPOSURE, HIGHEST RADIOACTIVITY LEVELS HERE OBSERVED IN LIVER AND KIDNEY. THE RADIOACTIVE METABOLITES OF 14C-VINYL CHLORIDE HERE RAPIDLY EXCRETED, LARGELY BY THE KIDNEYS. EXCRETION OF RADIOACTIVITY IN THE URINE HAS 69.4 ,PLUS OR MINUS 2.6 X WITHIN 24 HR. VCM, INHALATION (METABOLISM iRAT '^ ^ DISPOSITION; ARCH TOXICOL} ^: 1990 ITEM 264 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE 'abstract 675 GEN PUBLICATION -.1 -i PHARMACOKINETICS OF VINYL CHLORIDE IN RHESUS MONKEY ^ BUCHTER ANONE}FXLSER JG.NONEfBOLT^RfJNOHEjPETER H,NONES $ NONE,VOL 6 PP.33-36J m 1980 THE METABOLIC ELIMINATIOKJ^VlNYL CHLORIDE IN RHESUS MONKEYS IS A DOSE-DEPENDENT,SATURABLE PROCESS, AS IN RATS. BEL#5O0-3OO PPM OF VINYL CHLORIDE |VC)<IN ATMOSPHERE, ELIMINATION OBETS A FIRST-OROER LAM} THE CLEARANCE RATE IS MUCH CLOSER TO THAT FOUND IN MAN THAN THE VALUES FOR RATS, MICE AND GERBILS. THgUAXINAL VELOCITY OF METABOLIC ELIMINATION Of VC AT HIGH CONCENTRATIONS IN RHESUS MONKEYS IS OBEY ABOUT HALF OF RATS WHEN RELATEO TO KS BODY HEIGHT. IT IS SUGGESTED THAT RHESUS MONKEYS MOVt THE QUANTITATIVE ASPECTS OF'VC METABOLISM,BETTER THAN RATS OR MICE. JVs- ,* I rt t-tinTmiT rnr, cry mur^ PRINTOUT FOR VARY ORDER NUMBER 660SE7-155E59-HIZ >001-0 PAGE 99 SET 4 WIT)* MS OF -S3 ' DESCRIPTORS MNHHlfib' VCH}INHALATION HELD TERHS REVIEH YEAR RHESUS^ NOMWJ' 1990 ? ACCESSION NUMBER 674 FILE LOCATION 6EN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT STUDIES ON THE METABOLISM OF VINYL CHLORIDE AUTHOR/AFFILIATION ANTWEILER H*NONE XJV ORIGIN NONE,VOL 17 PP.217-219S DATE 1976 ABSTRACT VINYL CHLORIDE (VCM) IS NOT CARCINOGENIC BY ITSELF IT IS BIQACtlVATED TO THE HIGHLY REACTIVE ALKYLATING OXIRANE CHLOROETHYLENE OXIDE. FURTHER METABOLISM* APPARENTLY* LEADS VIA AN INTERACTION OF THE PRIMARY ALKYLATING METABOLITES WITH 6LUTATHI0N TO 8>(t-CARBOXTMETHYL>-CYSTEINE AND THIODIACETIC ACID MUCH ARE ELIMINATED WITH THE URINE. DESCRIPTORS jhhhhhh* VCMiMETABOLISM HELD TERMS S-( 2-CARBOXYMETHYD-CYSTEINEJ ENVIRONMENTAL HEALTH PERSPECTIVES* CHLOROETHYLENE OXIDE; THIODIACETIC ACID} ` REVIEW YEAR 1990 , 286* ~ ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ******* REVIEW YEAR 673 - ;' - ' GEN , JOURNAL .<*. RISKS TO THE OFFSPRING FROM PARENTAL OCCUPATIONAL EXPOSURES- 1 " ' i HAAS JFNONE}SCHOTTENFElD OpNONfl a&aHM JOURNAL OF OCCUPATIONAL HEOICINE >VOL 21 NO.9 PP.607-6131 1979* SEPTEMBER VCM IS DISCUSSED AS ONE OF SEVERAL COMPOUNDS WHICH HAY POSE A REPRODUCTIVE RISK. VCh;REPRODUCTION{TERAT06ENICITY*MUTAGENICITY*HUMAN}EFFECTS;CHROI1DSOMAL ABERRATION 1990 . ITEM 287 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE ABSTRACT 672 6EN PUBLICATION THE ROLE OF RESPIRATION IN VINYL CHLORIE EXCRETION- IN RATS ZUCCATO ENONE}MARCUCCI F,NONE;MUSSIf NONE,VOL 5 PP.213-217* 19B0 1,5 AND 10 MG/KG VINYL CHLHpE HONOMER (VCM) IN AQUEOUS SOLUTION HERE INJECTED I.V. INTO HALE RATS WITH CANNULATED JPACMtSi RESPIRATORY ACTIVITY HAS REGULATED TO PERMIT INVESTIGATION OF THE EFFECT OF MODIFYING PUUfRARY VENTILATION ON VCM EXCRETION IN BLOOD AND EXPIREO AIR ASSAYED AT DIFFERENT INTERVALS .HT VCH. VCM EXCRETION RATE HAS FOUND-mlE DIRECTLY PROPORTIONATE TO PULMONARY VENTILATION. WHEN RESPIRATION NAS STOPPED FOR' 1'Hi#, AFTER YCM INJECTION* THERE HAS NO DECREASE IN BLOQVCM, THE MAIN ROUTE OF EOMINA^ON OF .XlVi^tNJECTED. VCM THUS BEING PULMONARY. nprurnur for gary jonfs , \ >' V ' J 2089*101 bjiUJI AtHj UlJ) lilUllll.nl u. ^f-4 r r { aaNiwaaiao svm tvNav*uo aiov Idtin aamand oNvsainonouoaDvu DiivaaH ox annog atin3tvaod All^AUO_ VOIQtd4 3CTSOdX3 .......HOJ-dH 9 MOd DA 391 dO Udd 0005 tfO *0001*005*052*001*05*52 *oi*i oi oasodxa auan siva AaiMva-anDVads rivu *oaia ni sainoaiouotnvu ao nouvtamtv oniHdoaioaia oi aaivraa ao ivu sisafiiaoNtoavo aaonaNZ-OA di aNiuaaiaa oi aaiarus svm oa> aoiaoiHo 1ANXA aaiasn-39i oi oasodxa siva hi saiftoaioHoibvu DiivaaH oi aiiaxidvoiovu ao snionis anstvaod 9461 *64S-I4S*dd 99 10A*03I1ddV ONV X01 23UVSTd 9NHM39!3UVS*99 993di3MVS`Vr 13dW3250D 1VDIU3HD M00*9d 39VNV1VM aoianra tania oi aaosodxa snihoiioj snionza annosTowodovn onvd3H Honvanend N39 699 lDVdlSQV 31V0 NI9Id0` Noiivnujv/aoHinv loarons do aim 3dAl INaunDOO NOI1VDOT 31ia aaeunN noiss3ddv 062 Half '* * - 0661 aval M3IA3U !33NVlfVai32N0Xlt80dSia suaai oi3H U6nogViaU!SlVd2N011V1VHNI!M3A ******* Sd01dIdDS3Q r1-' '/7.-(d69) NiaivHdinsuoaQ jo aoNvavaio wnaas am asuv ion do da udd oooi oi aunsodxa'fosiv AeanoH 4 mqj Da udd 01 anav oaiaasso svm Noissaudao on onv *iwaisisN0DHi svn N0ics3ddaa am sanon 4 aoa DA Wdd os 01 awsodxa oHiMonoa *in3inod naaiHains Hiaioad-NON DiivdaH am. ao Uoxssaadaa BAissaa9oad v aasnvo da udd ost onv 052*0001*0002 01 3dnSOdX3 'JLN3-LN0D TAdQAHdinS NI310dd-N0H DIlVd3H 3HI NO DA 30 133333 3Hi 3NIUd3130 01 SdflOH 4-1 MOd (DA) a0Id01H3 UNIA Udd OI ONV 05*051*052*0001*0002 dO S3tt3HdS0UlV 01 03SOdX3 3d3M SIVd lovaisav 9461 31VQ OD TVDIW3HD MOO HI9iaO J3UVS*rd flNIdH3913UVS*3a d3N33H!0D 1VDIU3HD M00`9d 39VNV1VM Noiivniaav/aoHinv (dS9) NiaiVHdinSOUOdQ no sioaaaa onv in2anqd lUKunains Niaioad-HON aiivaaH ao Noissaudao aaonoNi aaiaoiHD tania xaargns ao aim d3dVd 3dAi iNaunooa N39 noiivdoi ana 049 BiSUnN N0ISS3DDV 693Uilf . 0661 aval M3iA3d .<ta * v HsnoaviauiNOiinvHNiiHDA ****** SdoididDsaa - * '** ' '* V'-'. #' 91 B39H3A0N *9461 31V0 J,'e -1" saavis iwiNno oaNifluoD iv oaiN3saad*oD 1VDIH3HD moo NI9IB0 J3NVS*rd 9NIdH392aMVS*d9 NVH09DN23UVS*3d &3Nd3H!OD TVDIW3HD H00*9d 38VNV1VM Noiivniaav/aoHinv aOIdOlHD TANIA JO USIT08V13W iDsrans ao aim d3dVd adll 1N3UODOQ . N39 noiivdoi ana C;r:- v 1 149 aasum noisssodv -' " 0661 11131 JA0103IXCU1NOIlISOdSIO NOIlVNIHn31AI2SlVdJS9Nm !MDA dV3A M31A3H suaai oiaH saoididDsaa SU31I595,40 595 H1IM 9 138 001 39Vd |0fl-I00- 2IM-652551-420098 tQOjnN d30d0 lavs tna imiNidd BFG52790 PRINTOUT FOR OARY.JONCSj >#0l Vi ORDER NUMBER B60827-135259-MIZ PAGE 101 BET 4 WITH 365 OF -001-ar4' ^ ^ fT : THE TOTAL AHOUMpOF ^' DETERMINED/ THE TOTAL; INCREASE PROPOR DECREASE IN COVALENT BINDING EXPOSURES GREATER HITH INDUCTION OP HEPATIC EITHER DMA OR RNA IN THE UVER. HEPATIC 6LLTTA EXPOSURE CONCENTRATIONS GREATER THAN 100PPM. DESCRIPTORS ****** vcm;metabolism;liver;inhalation;rats HELD TERMS hACROMOLECULAR BINDING;COVALENT BINDING REVIEW YEAR 1990 *rV Stem 291 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE DESCRIPTORS ninWnhtUinJnlfMT HELD TERMS REVIEW YEAR 666 GEN PUBLICATION A PROCEDURE FOR PREPARING 14C-LABELE0 VINYL CHLORIDE HAGNER ERNONE;HUELOER HUNONES NONEVOL 246PP.152-1531 : 1975 JANUARY 31 VCM SYNTHESIS (RADIOLABELED )ANNALS OF THE NEH YORK ACADEMY 1990 . E9E ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELO TERMS REVIEH YEAR 667 f ^ GEN ' ' PUBLICATION CYTOCHROME P-450 AND THE METABOLISM OF VINYL CHLORIDE SALMON AG>ICI; NONE,VOL 2 NO.8 PP.109-114; 1976 THE OXIDATION OF VINYL CHLORIDE TO NON-VOLATILE PRODUCTS IS DEPENDENT ON NADPH AND MICROSOMAL ENZYMES. THE ADDITION OF VINYL CHLORIDE TO MICROSOMES CAUSES A TYPE 1 SPECTRAL SHIFT* SIMILAR TO THAT SEEN FOR PHENOBARBITALC11)WHICH INDICATES THE DIRECT INVOLVEMENT OF A CYTOCHROME P-450 SPECIESJTHIS DIFFERENCE SPECTRUM IS CHARACTERISTIC OF SUBSTRATE,BINDING TO THIS TYPE OF ENZYME. A GLUTATHIONE CONJUGATE IS PROBABLY FORKED* PERHAPS VIA A REACTIVE INTERMEDIATE. vcm;metabolism;xn vitro;rats;liver CANCER LETTER? ti 1990 .I (ITEM 293 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 666 GEN " - ?- JOURNAL ?& .. A GAS-CHROMATOGRAPHIC METHOD1 FOR THE PREPARE $Xtffli*CHLORZOE -r' J; - '-v "Tf'IIT rnp PAMY IPMfP $ f? G 5 2 7 9 2 PRINTOUT Tor cart OROER NUMBER B60827-135259-WIZ r . -OOl-Otll O PAGE 102 SET 4 WITH 385 0P S84|1TEMS AUTHOR/AFFILIATION v WAGNER ER,OOtfCHEHici PJ.SAMEJ ' ' ORIGIN NONE.VOL 11 N0.4 PR; DATE 1975 *1 DESCRIPTORS **"** VCWMI .. s HELD TERMS SYNTHESISJRAOXO LABE LED | >0 REVIEW YEAR 1990 '* *'" ,t v,S.. - '`''''S'1' m* H' Item E94 ACCESSION NUMBER 665 FILE LOCATION GEN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT ACTIVATIN OF VINYL CHLORIDE TO COVALENTLY BOUND METABOLITES*: ROLES OP 2-CHLOROETHYLENS OXIDE AND 2-CHLOROACETALDEHYOE , v-- AUTHOR/AFFILIATION GUENGERICH FPNONE{CRAWFORD HMNONElHATANABE PGtNONEi - ORIGIN NONEiVOL 18 NO.23 PP.5I77-5182{ - DATE 1979 DESCRIPTORS **# VChlMETABOLISMjIN VITROIRATSLIVER HELD TERMS COVALENT BINDING!ACTIVATION 12-CHLOROETHYLENE OXIDE52-CHLOROACETALDEHYDE,BIOCHEMISTRY REVIEW YEAR 1990 -tartly- ,f ITEM 295 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 664 GEN PAPER %: i: TESTIMONY: PHARMACOKINETICS OF VINYL CHLORIDE GEHRING PJ.DOW CHEMICAL CO; DOW CHEMICAL CO,FOR HEARING ON ERA'S PROPOSED STANDARD FOR VINYL CHLORIDE; 1976, FEBRUARY 2 f USE OF PHARMACOKINETICS IN RISK ASSESSMENT. EXTRAPOLATION OF RODENT DATA TO MAN. VCM AN EXAMPLE. VCM!INHALATION;CARCINOGENICITYSRATSJHUftANS INCIDENCE;LOW OOSE EXTRAPOLATION 1990 S'tTEM 296 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN 'ATE ABSTRACT 663 GEN JOURNAL ACRO-OSTEOLYSIS OCCURRING IN MEN ENGAGED IN THE POLYMERIZATION OF VINYL CHLORIDE HARRIS dk,ici;adahs hgf*same; > NONE,VOL 3 PP.712-714; 1967 TWO CASES OF ACRO-OSTEOLYSIS OCCURRING IN MEN ENGAGED IN THE POLYMERIZATION OF VINYL CHLORIDE ARE DESCRIBEO. THE BONES AFFECTED HERE THE TERMINAL PHALANGES OF THE FINGERS AND THE SACROILIAC JOINTS, BUT IN ONE CASE THE PATELLA AND IN THE OTHER THE PHALANGES OF,THE FEET HERE INVOLVED* THE CONDITION HAS ACCOMPANIED BY RAYNAUD'S PHENOMENON AND SKIN UStONS. it WOULD SEEM THAt THIS CONDITION IS PROBABLY A SELF-LIMITING DISEASE. 'Jf* r!iT,rop r/vnr iroir* PRINTOUT FOR GARY ORDER NUMBER 660ai7-lS5259-WXZ -D0*- PAGE 103 SET 4 HXTM 365 OP 30* DESCRIPTORS *WNhhh* * ACROOSTEOLTSIS HEU) TERNS r-"\ REVIEW YEAR ITEM 297 ACCESSION NUMBER 662 FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT SEN REPORT ? ` 2-PRQPENOIC ACID* POLYMER WITH BUTYL 2-PROPENOATE* 1,1-DICHUjROETHENt AND N-(HYDROXYMETHYL1-2-PROPENAMIDE (CAS# 35743-24-9IJ BPS TSCA lWENTORY SUBMISSION* PORN* B21464508, AUTHOR/AFFILIATION AVON LAKE. NONE* NONE; ,. ^ '' =* " ORIGIN OFS-CHEMICAL, TO EPAJ DATE 1970 ABSTRACT TSCA INVENTORY SUBMISSION OF GEON 660X2. DOCUMENT IN CHEN GROUP ENVIRON AFFAIRS DEPT FILES. DESCRIPTORS ******* CAS.N0.35743-24-91TSCA XNVENTORYiGEON 660X21 AA*B -P*ll-0CE*N-HM-2-PA REVIEW YEAR 1990 r ITEM 290 1 ACCESSION NUMBER FILE LOCATION 660 GEN f DOCUMENT TYPE REPORT TITLE OR SUBJECT 2-PROPENOIC ACID* POLYMER WITH BUTYL 2-PROPENOATE AND CHLOROtTtfENE (CAS* 26073-66-5)* BF6 TSCA INVENTORY SUBMISSION* FORMS B21463724* LOUISVILLE* AUTHOR/AFFILIATION NONE,none; .* -= * .* - ' V-. * ORIGIN BFG-CHEMICAL, TO EPA) J `* *' DATE 1970 ABSTRACT TSCA INVENTORY SUBMISSION OF GEON 350X42. DOCUMENT IN CHEN GROUP ENVIRON AFFAIRS DEPT FILES. DESCRIPTORS ******* CAS.N0.26073-66-5IT8CA INVENTORYGEON 350X42; ACRYLIC ACXOtttttjrL 2-PROPENOATE,CHLOROETHENE POLYMER J.=- rti, ' * REVIEW YEAR 1990 1" ITEM 299 ACCESSION NUMBER 659 - : FILE LOCATION GEN DOCUMENT TYPE REPORT , TITLE OR SUBJECT 2-PROPENOIC ACID* POLYMER WITH BUTYL 2-PROPENOATE AND CHLOROtTHENE (CAS* 26073-66-51* BF0 TSCA INVENTORY SUBMISSION, FORMS B21464500* AVON LAKE*: : . AUTHOR/AFFILIATION NONE,NONE; " `tf. ' ' "" ORIGIN BFG-CHEMICAL* TO EPA; ' c DATE 1970 ABSTRACT TSCA INVENTORY SUBMISSION OF GEON 460X2. DOCUMENT IN CHEN ENVIRON AFFAIRS DEPT FILES. DESCRIPTORS ******* CAS.N0.26073-66-5ITSCA INVENIDRUGEON 460X21 2-PROPENOATECHUWOrmENE POLYMER y REVIEW YEAR 1990 * * i,k. PPTMWMT FOR PARY JONFR r> PRINTOUT FOR 6ARY ORDER NUMBER 660B27-135259-HIZ -OOl-OOl PAGE 104 SET 4 WITH 305 OF 3*5 ITEMS 24*, ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 647 6EN BOOK PERCUTANEOUS ABSORPTION OF VINYL CHLORIDE HEFNER RE.NONE!HATANABE PG,NONE;GEHRING PJ.HOIttt; TOX AND APPLIED.VOL 34 PP.529-532! 1975 PERCUTANEOUS ABSORPTION OF 14C-LABELED VINYL CHLORIDE (VC) ilA$ EXAMINED IN HALE RHESUS MONKEYS. TWO MONKEYS HERE EXPOSED (WHOLE BODY. EXCLUDING THE HEAD) TO ATMOSPHERES CONTAINING 7000 AND 600 PPM OF VC FOR 2.0 AND 2.5 HR.RESPECTIVELY. THE AMOUNT OF VC ABSORBED AT 7000 AND 600 PPM HAS 0.023 AND 0.31X OF THE RESPECTIVE TOTAL VC AVAILABLE FOR ABSORPTION. THE MAJORITY OF THE VC ABSORBED MAS ELIMINATED BY THE LUNGS. vcm;absorption;skin ATMOSPHERIC EXPOSURESPERCUTANEOUS ` 1995 -ITEM 301 ACCESSION NUMBER 646 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION TITLE OR SUBJECT HEPATIC LESIONS CAUSED* BT VINYL CHLORIDE MONOMER IN HUMANS) STUDY OF EIGHT CLINIC0PATH0L06ICAL CASES ~. AUTHOR/AFFILIATION PIALAT J.NONEtPASQUIER B.NONE.PAHN M,NONE;KOPP N.NONE. ORIGIN NONE.VOL 27 NO.6 PP.361-375! DATE 1979 ABSTRACT SIX HEPATIC ANGIOSARCOMAS. ONE HEPATOMA AND ONE HEPATIC FIBROSIS WITH PORTAL HYPERTENSION IN PATIENTS CHRONICALLY EXPOSED TO VINYL CHLORIDE MONOMER (VCM) ARE REPORTED. THE IWJUSTRIAL HETHOOS OF SYNTHESIS ANO CURRENT KN0ULE06E CONCERNING THE CARCINOGENIC ROLE OF VCM ARE REVIEWED. HISTOGENETIC AND PATHOGENETIC C0NCETP3 OF FIBROSIS AND ANGIOSARCOMAS OF LIVER ARE EXPQSEO. DESCRIPTORS ******* VCM.ANGIOSARCOMA!LIVER!CANCER{HUMANlEFFECTS ' HELD TERMS ARCH ANAT CYTOL PATH REVIEW YEAR 1990 ITEM 302 ACCESSION NUMBER 645 FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT 2-PROPENOIC ACID. BUTYL ESTER. HOMOPOLYMER (CAS6 9003-49-0)* BF6 TSCA INVENTORY SUBMISSION* FORM# A12797163. LOUISVILLE. f . 'author/affiliation NONE.NONE! ^* ORIGIN BFG-CHENICAL.TO EPA! " DATE 1978 V ABSTRACT TSCA INVENTORY SUBMISSION OF 6E0N 300X17. ACRYUt ACID. BUTO fcSTER POLYMER. DOCUMENT IN CHEM GROUP ENVIRON AFFAIRS DEPT FILES. ! ~- DESCRIPTORS ******* CAS.NO.9003-49-0!TSCA INVENTORY!6EON SOOX17St-t*iOFNOICActflBUltL ESTER POLYMERTBUTU ACRYLATE zoss^osfg $ ct||' ;||s|| ' *r. ^ % o 4? i'!'1"! (on r^nr mnpn /''v'*.1' ... PRINTOUT FOR GARY ORDER NUMBER fi60627-135259-NIZ r PAGE 105 SET 4 HITH *65 WL. 1 -v - -m, * V * V POLYMER $6 REVIEW YEAR /"-V K' *'* ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS HELO TERMS COMMENTS REVIEW YEAR fff. ..................... gETEM 304 619 GEN JOURNAL INVESTIGATION OF THE DISEASES PROOUCED BT VlNTL CHLORIDr SUCXU I,NONE, .V'-: -n*. ' NONEVOL 15 PP. 967-7B5 1963, AUGUST VINYL CHLORIDE)TOXICITY LIVER OAMAGE;i1EOICINA INTERNA (BUCHAREST); INSTITUTE OF HYGIENE OF CLUJ; MNJ(64I CLASSIC EARLY PAPER ASSOCIATING VCH EXPOSURE WITH BOTH LIVER AND SCLERODERMAL LIKE EFFECTS. v 1990 x^ ' ACCESSION NUMBER 616 FILE LOCATION GEN DOCUMENT TYPE JOURNAL 7; ;; TITLE OR SUBJECT ANGIOGRAPHIC AND RADIONUCLIDE CHARACTERISTICS OXP HEPATIC ANUS9ARCOMA FOUK) IN VINYL CHLORIDE WORKERS *- r V AUTHOR/AFFILIATION WHELAN JGtUNIV OF LOUISVILLE {CREECH JL.NONE9TAMBURRO CttfMNE] ORIGIN NONE,VOL Hfi NO.3 PP.549-557; ' u DATE 1976, MARCH - ' L 7` DESCRIPTORS * VINYL CHLORIDE{ANGIOSARCOMASLIVER HELD TERMS angiography;LIVER SCANSIRADlOLOGY REVIEW YEAR 1990 &TEM 305 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 600 GEN JOURNAL THE PATHOLOGY OF 111 CAES OF PRIMARY HEPATIC MALIGNANCY COLLECTED IN THE LIVERPOOL REGION CRUXCKSHANK AH,NONE; .. NONE,VOL 14 PP.120-131; , 1961, MARCH V THE CLINICAL RECORDS AND PRESERVED SPECIMENS OF 111 CASES OP HttNART MALIGNANT DISEASE OF THE LIVER HAVE BEEN ANALYSED. ALL HERE DIAGNOSED IN THE MERSEYSIDEAREA, CHIEFLY IN LIVERPOOL AND BIRKEMiEAD, AND ALL BUT NINE HERE EUROPEANS. NECROPSY WAS DONg IN 69. THE TUMOURS CONSISTED OF 106 CARCINOMAS, TWO SARCOMAS, AND ONE MIXED TUMOUR. LIVER CELL CARCINOMA WAS NEARLY FOUR TIMES MORE FREQUENT THAN CARCINOMA OF THE INTRAHEPATIC BILE DUCTS. jOTW TYPES HERE COMMONER IN MALES, THE DIFFERENCE BETWEEN THE SEXES BEING GREATER IN THE CASE 0* UVR CELL CARCINOMA. PREDISPOSING CONDITIONS INCLUDED PORTAL CIRRHOSIS, HAEMOCHROHATOSIS, ANG CYSTIC MALFORMATIONS OF BILE DUCTS. THE GROSS AND MICROSCOPIC APPEARANCES ARE DESCRIBED AND THE /PATHOLOGICAL EFFECTS DISCUSSED. LIVER CELL CARCINOMA TENDS TO INVADE AM) PERMEATE VElMSt WTTH BUTSEEH8, NEVERTHELESS, TO * ? i' pi>THimtr rno pary ionfs . v1 C:i f PRINTOUT ORDER NUMBER S60627-135259-HXZ PAGE 106- SET 4 WITH 365 OP ttS.-tlcnai DESCRIPTORS HELD TERMS REVIEH YEAR #>." `-v flTEM 306 REMAIN LIMITED TO THE tXVER FOR LONGER THAN CARCwOHA'OP: CARCINOMA IS MORE CHARACTERISTIC MICROSCOPICALLT^TME NAS SEAFARER. hhhhh VCM,LIVER(CANCER(HUMAN(EFFECTS J.CLIN.PATH.tUNZV OP LEVfeRPOQfr 1990 a-M ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS **** REVIEW YEAR 599 GEN PUBLICATION OCCUPATIONAL ACROOSTEOLYSIS - A CLINICAL INVESTIGATION OP POLYVINYL CHLORIDE SYNTHESIS HORKERS DINMAN BO.UNIV OF MICHIGAN(DODSON VN,SAMEMAGNU80N HJ,SAMEHHlTEHOUSE NM SAKE; UNKNONN 1969 VCM;AOL;HUMAN}EFFECTS is.' v*c,.~ ;* 1990 vITEM 307 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEW YEAR 598 GEN JOURNAL OCCUPATIONAL ACROOSTEOLYSIS! PART III. A CLINICAL STUDY DODSON VNUNIV OF HICHI6AN;DINHAN BD * SANE (WIT(MOUSE NMttAMtfclfcSR ANNSAME;KAGNUSON HJ.SAME? ARCH ENVIRON HEALTHVOL 2 PP.63-91; 1971, JANUARY FOUR SUBJECTS UITH ACROOSTEOLYSIS HERE STUDIED CLINICALLY. ALL HAD OSTEOLYTIC LESIONS* ESPECIALLY IN THE DISTAL PHALANGES OF THE HANDS* AND RAYNAUD'S PHENOMENON. ALL HAD HORKED AS POLYVINYL CHLORIDE REACTOR-VESSEL CLEANERS* WITH HAND SCRAPING BEING THE COMMON MODE OF OPERATION. RAYNAUD'S PHENOMENON ANTECEDED OSTEOLYTIC LESIONS, ONE OF THE SUBJECTS HAS IN NEGATIVE CALCIUM AND PHOSPHORUS BALANCE. PLETHYSMOGRAPHIC ABNORMALITIES HERE PRESENT IN THREE. ESOPHAGEAL MOTILITY WAS NORMAL. SCINTISCANS OF THE HANDS USING SODIUM FLUORIOE LABELLED WITH RADIOACTIVE FLUORINE (F) REVEALED VARIABLE UPTAKES IN THE FINGERS WHICH CORRELATED WITH THE RADIOGRAPHIC LESIONS. A HIDE VARIETY OF CLINICAL LABORATORY PARAMETERS HERE NORMAL. VCM(AOL{HUMANSEFFECTS 1990 ITEM 306 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 597 GEN JOURNAL OCCUPATIONAL ACROOSTEOLYSIS! PART I. AN EPIDEMIOLOGICAL _ DINMAN BD*UNZV OF MICHIGAN;COOK HA,SAMEIWHITEHOUSE 1,SAMffr-NAGNUSON HJ,SAME JOITCHECK T.NONE} ARCH ENVIRON HEALTH*VOL 22 PP.61-73; 1971, JANUARY ' AN EPIDEMIOLOGICAL STUDY HAS PERFORMED COVERING 5*011 EMPLOYEES HITH 21,510 MAN-YEARS EXPERIENCE IN VARIOS PHASES OF VINYL CHLORIDE (VCI AND POLYVINYL CHLORIpjMPVCJ; MANUFACTURING ZN 32 PLANTS 20898107 i* - . *'. * A' BFG52796 1111111r"tr rnn fapy infirm r A- CeSSlOS mINTOUT FOR ARY ORDER NUMBER 860887' -135859-WIZ cQOl* PAGE 107 SET * MITM SOS r 5'^' #throughout to* rJS` united irfijtsfw*) Canada! DESCRIPTORS REVIEH YEAR <A0L) HAS 85IW; 0THCR;;INR1VX0UALS HERB UNDER SUSPICI WITH THE HAND CUMlM^MtnERlZERS. HQRKERS MANUFACTURING SGiNOT APPEAR j^fcSE AYr ' PHENOMENON AAS -A !C0M^%<IW'AOL'tS MEDICAL SURVEY ARE-SUSSEOTEffl^CROOSTEOLYnSv PRESENTLY* NEITHER THE fcTIOLOSSCAL ABENT NOR vch;aol;human)EFFECTS 1990 309 ACCESSION NUTCER FILE LOCATION OOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ****** HELD TERMS REVIEH TEAR 595 GEN JOURNAL *> MUTAGENICITY OF VINYL CHLORIDE*VINTLIDENE CHLORIDE AW CHUROFRENE IN V79 CHINESE HAMSTER CELLS OREVON CNONE;KUROKI T,SAMEJ <, V NONE*VOL 67 PP.173-102; 1979 VCM MAS MUTAGENIC BUT VOC AND CHLOROPRENE MERE NOT. VCM!MUTAGENICITYlIN VITRO;CHLOROPRENE;VDC fflv&'i A ,csv* IAPC; MUTATION research; 1990 < , * . > ITEM 310 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEH YEAR V 594 ' * 6EN JOURNAL CARCINOGENICITY OP CHLOROETHYLENE OXIDE*AN ULT] ,Te r A50LITE OF VINYL CHLORIDE* AND BISICHLOROMETHYLIETHER AFTER SUBCUTANEOUS AO| ATIOHAHB XNXTIAnON-FRONOTZaN EXPERIMENTS IN MICE ZAJOELA F*NONE;CROISY A,SAME?BARBIN AjfffiE ;MALAVEILLE CSAMEtfdilAhs\, SAMEJBARTSCH H.SAME I CANCER RESEARCHVOL 40 PP.352-356; ^ 1980* FEBRUART y* OUR RESULTS SUPPORT THE HYPOTHESIS THAT EPOXIDATION OF THE EtHYLENIC DOUBLE BOND IN VINYL CHLORIDE YIELDS AN ULTIMATE^KRCINOGENIC METABOLITE* CHLOROETHYLENE OXIDE* A HIGHLY REACTIVE COMPOUND MHICH APPEARS U0O TO BE LARGELY RESPONSIBLE FOR THE KNOW GENETIC CHANGES CAUSED BY THE PARENT COMPOUND. VCMiCARCINOGENICITY;jRTS-CHLOROMETHYL ETHER(NETABOLZSMiHICEfSUBCUTANEOUS CHLOROETHYLENE OXjRfi IARCJ 1990 311 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 593 & GEN 1 '5 RESEARCH LAB REPORT HEPATIC MACROMOLECULAR BINDING FOLLOWING MATANABE PG.DOH CHEMICAL CO;EMPELOA*SAflEIPE *, *> r f, I . * "rrmtr rr>n rpY inurt 05119 8 PRINTOUT FOR 6ARY JONKS ORDER NUMBER W0027-135259-HIZ . .^OlH^iJ&gL PAGE 108 SET 4 KITH MS OP M'ITEMS , ORIGIN DON CHEMICAL fcO.TOXICtiLogY RESEARCH LAB* OATE 1977. APRIL 5 * -s tl. , iU ABSTRACT THE COVALENT BXNOING TO jfeptffc MACROMOliCULES HAS RELA EXPOSURES GREATER'THAN SffPPHf^IHe AHOUMT OF WITH INDUCTION OF HEPAtZCXANSpSARCOtjAw THEM EITHER ONA OR RNA IN THE LIVER* HEPAtlC ftWTA1 EXPOSURE CONCENTRATIONS GREAtOl THAN 100' Pm? DESCRIPTORS VCMJDNA HELD TERNS COVALENT BINOXNSiALKYlATXONJMACROMOLECULARtRNA; REVIEW YEAR 1990 AMOUNT OF VC MET, CULES IN TNE ING OFRAD ^ ICANTLY pEFREtt r- RELATES YD . ONLY At ITEM 312 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ******* HELD TERMS REVIEW YEAR 592 GEN JOURNAL ,y LACK OF MUTAGENIC Ef#ECT OF VINYL CHLORIDE MONOMER IN 'm&MAJtlALXAN SPOT TEST PETER s,none;ungvarT 6>none; V* NONEiVOL 77 PP.1RF196J 1960 M VCMilN VIVO;MUTAGENICITY MAMMALIAN SPg$FTEST; MUTATION RESEARCH 1995 ITEM 313 ACCESSION NUMBER FILE LOCATION 591 GEN S' DOCUMENT TYPE JOURNAL TITLE OR SUBJECT DMA ALKYLATION BY VINYI CHLORIDE METABOLITES* ETHENO DERIVATIVES OR 7-ALKYLATION OF GUANINE7 AUTHOR/AFFILIATION LAIB RJtMONEiGUXtMER, SAMEJBOLTHM,SAME ORIGIN NONEVOL 37 PP.219-J DATE 198! A ABSTRACT IT IS CONCLUDEO THAT THE COMPOUND DESCRIBED BY THESE AUTHORS* 7-N-< 2-OXOETHYL)GUANINE IS IN FACT THE MAJOR PRODUCT 0? BASE ALKYLATION IN DHA AFTER EXPOSURE TO VINYL CHLORIDE. DESCRIPTORS WMXM*K VCM 0NA;INHALATION RATS;LIVER HELD TERMS 7-N-(2-OXOETHYL)WANINE;ALKrLATION; UNIV OF MAINZ (GERMANY) tCHEM. BIOL. INTERACTIONS; REVIEW YEAR 1990 M ITEM 314 ACCESSION NUMBER 590 ' - -- FILE LOCATION GEN V .DOCUMENT TYPE JOURNAL TITLE OR SUBJECT ROLES OF 2-HALOETHYLENE OXIDES AND B-HALOACETALDEHYDES DERIVED FROM VINYL BROMIDE AND VINYL CHLORIDE IN IRREVERSIBLE BINDING TO PROTEIN AND DNA > AUTHOR/AFFILIATION GUENGERICH FP.NO^f JMASON PS.SAME;STOTT NT,DOM CHEMICAL COjPOK TR, SAtie;HATANABE PG,3ANe; ORIGIN CANCER RESEARCH 41 PP.4391-4398*. DATE 1981, NOVEMBER DESCRIPTORS ******* vcm;dna ;chlori ETALDEHYDE r-muTniir rnp papy inNrs rrtR*c?r f o PRINTOUT FOR CART JONES ORDER NUMBER 860827-135259-WIZ . -0 PACE 109 , SET A MITH 365 OF 56* HELD TERMS REVIEH YEAR /Tv V >J IRREVERSIBI I" ACCESSION NUMBER 589 PILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT JOURNAL , .... MUTAGENICITY IN VITRO AND POTENTIAL CARCINOGENICITY OP CHI ethylenes as a function or METABOLIC OXIRANE FORMATION V Ji'V AUTHOR/AFFILIATION GREIM H,NONE}BONSE G.NOHEIRADHAN Z,NONE {REICHERT D,N0NE}HESCTUR D.NONE} ORIGIN NONE,VOL 24 PR.2012-2017} DATE 1975, JULY DESCRIPTORS wm vcii;tetrachloroetnylene;trichloroethylene;ethylene dichlorideimutagenicity; in vitpojoxirane HELD TERMS EPOXIDES}CHLORINATED ETHYLENES}CHLORINATED HYDROCARBONS}BIOCHEMICAL PHARMACOLOGY REVIEH YEAR 1990 ^ ITEM 316 ACCESSION NUMBER 588 FILE LOCATION GEN OOCUMENT TYPE TITLE OR SUBJECT JOURNAL REACTIVE METABOLITES AND CARCINOGENXCI1 HAL0GEHATED ETHTUeNEC AUTHOR/AFFILIATION BOLT HMNONE}LAIB RJ,NONE}FILSER ORIGIN NONE,VOL 31 ND.l PP.1-4J DATE 1952 ABSTRACT COVALENT BINDING,METABOLZSKjK) MUTAGENICITY OF VCM,VINYL FLUORIOE,VINYL XDENE FLUORIDE, V1NYLIQENE CHLORIDE,EDC, TRlfnLOROETHYLENE, PERCHLOROETHYLENE,VINYL BROMIDE. DESCRIPTORS <hhhhhh VCM;VINYLIDENE CHLORIOEjUTHYLENE OICH LOGIOE{TRICHLOROETHfLOAlPERCH LOROETHYLENE {MUTAGENICITY} METABOLISM HEU) TERMS COVALENT BINDING; VIJ^l FLUORIDE}VINYUDENE FLUORIDE;EDC}VIHYL BROMIDE} TCE}BIOCHEMICAL PHARMACOLOGY; REVIEH YEAR 1990 ITEM 317 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFT1IATION ORIGIN DATE ABSTRACT 5B7 { GEN RESEARCH LAB REPORT LIFE-SPAN ORAL TOXICITY STUDY OF VINYL CHLORIDE IN RATS FERON VJ, NONE} HENDRXKSEN. CFNNONE i SPEEK AJ,NONE(TIL HP,MEME}6fltf BJ, NONE* NONE,REPORT NO.R-5788? 1978, OCTOBER i' THE CARCINOGENICITY OF VCM (IN PVC AM) BY INTUBATION HAS STUDIED, A VARIETY OF NEOPLASTIC AND NON-NEOPLASTIC VCM-RELATED LIVER LESIONS HERE FOUND IN EACH Of THE TEST GROUPS. HEPATIC ANGIOSARCOMAS OCCURRED AT LEVELS OF 5.0 H6/KG AND HIGHER. HEPitOCELLULAR TUMOURS (NEOPLASTIC NOOULES AND CARCINOMAS) HERE FOUW IN ALL DOSE-GROUPS. THEIR INCIDENCE HAS HIGH IN BOTH SEXES OF THE 14.1 MG/KG GROUP AND IN FEMALES OF THE 1.7 AND 5.0 M6/K6 GROUPS, LOH IN MALES OF THE 5.0 MG/KG GROUP, AND MARGINAL IN MALES OF THE 1.7 MG/K6 GROUP. WUKMARY ANGIOSARCOMAS (MAINLY HETASTASES) AND A FEH EXTRAHEPATIC XNTRA- ABDOMINAL ANGIOSARCOMASrHERI; OBSERVEO AT .LEVELS OF 5.0 *#*5r 20ssmo*tf- t poTHTnUT FOR GARY JONES fA .1 S3-*-n* >n mm nm f- (UA !fT HI 3, oPsr .4 am <Mmz m< & mI om >Q9 puun b a na h ha > mJ)a-Hn <3A O 30 o >Hm o33 MOM2 a>C-3os>mm4. mHMHroa tfi o onc2 m ZH H mH rm* ian>-- >n mn (WMA a z M-m4 3 tI-Xj <0 ma zm <mmZ < ra Hma m> 3U) S<----Hl--o.--Kr-o*--Z-mz- B-dm> S-oLk-mfmlWioawj nt o> m mz oa O>-----z--~* < 3> HH Z> o 2 o r- :?*o oo z52m o"B < S5 rPTMTOlff FOR GARY JONFS > 'A~ -. ,".rtf ,s- ** o * B '' *.'.1 s.. PRINTOUT FOR GARY ORDER NUMBER 660627-135259-HIZ -901-00* (T' PAGE UI SET A WITH J OF 5M ITEMS ' !* ' . DOCUMENT TYPE TRADE ASSOCIATION RE TITLE OR SUBJECT FINAL REPORT; ^ BIO-TEST liBti AUTHOR/AFFILIATION .' NONCi.NONS? ORIGIN - CMA DATE 1976 ^ DESCRIPTORS wmtwwwM VCMiINHALATIONIRATS) HELD TERMS AUDITl REVIEH YEAR 1990 Stem" sei ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ******* HELO TERMS REVIEW YEAR 562 GEN RESEARCH LAB REPORT VINYL CHLORIDE PATHOLOGY REPORT NONENONE{ NONE*FOR MCA5 1979. JANUARY 9 AUDIT PATHOLOGY REPORT OF LONG-TERM INHALATION STUDY OF VCM ATIBT. VCM ;IMIALATXON>RATS;MICE {HAMSTERS; CARCINOGENICITY {CHRONIC-. PATHOLOGY;EXPERIMENTAL PATHOLOGY LABS* 1990 v item see4 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEW YEAR 581 ^ . "v Vj > 1 '"''f v i; > p.&y GEN TOXICITY STUDY l.rsi Jr CHRONIC VAPOR INHALATION TOXICITY STUDY WITH VINYL CHLORj *i SrftYlfeNt DERIVEDI IN ALBINO RATS ALBINO MICE AM) GOLDEN HAMSTERS-- 25-MONTH STATUS SUttlAR^ NONE,NONE? *..<-{ INDUSTRIAL BIO-TEST LABS,IBT NO. 665-05222; 1975, SEPTEMBER 25 THIS 23-MONTH STATUS REPORT 19/10/75-9/10/74) IS THE LAST REMRT RECEIVED FROM X8T. NO FINAL REPORT MAS EVER PROVIDED. SEE EXPERIMENTAL PATHOLOGY LABS,BOB NEST ASSOCIATES, AND AUDIT GROUP REPORTS. .. . vcm;inhalation;carcinogenicity;chronic;rats;mice;hamsters- 1990 :/. iXTEM 323 ACCESSION NUMBER .FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 560 GEN - >.. 1 TOXICITY DATA CHRONIC VAPOR INHALATION TOXICITY STUDY KITH NONE,NONES *, j> fK - INDUSTRIAL BIO-TEST UbSFQR^CMA{ j 1973, FEBRUARY PROTOCOL FOR LONG-TERM INHALATION STUDY KITH VQtiTL CHLQR a Bf CMA IMCAi/AT-DCUSTRlAL -V,. t-rfr jfrpP 'i printout for 6ary jones ' *?$> ftTO6802 bdNOI' AHVii dUJ lilOi.Ud.J % G O' & io Y fit; CTT86803 .ItibiflNXH&VM dQAXNfl nON3HdOH01H3VJipBldOdiNOIlV3WH3di 3N3Hd03N 1- j^OAdsaaoona aixaiXN;saA0i9 J - . - m *sanoH s isvai iv hoj aievidaoov avan 3A0i9 H39ond ivarnw amino nv *5*y ojl aaonaapsvM Noxinios isnvivho am nshm *AiaAXio3dS3a`sanoH 91 onv 9 hoj Noxivaunad on hohs oAd) 1019*019 ibnvho onv oiihiin) xba-ios siNouaa *31y aaivaag <nod-s v win ina*oainNiH 09 aauv wnoanmaHO oaivHisNouaa 3N3HdoaN/x3ivi S0N033S 0 NX H9nOHHlXV3HO 031181HX3 3A019 d390Ttd 1VHOLVNONV 3Ad Y H10S *OOH13W HSOIN Y QNISfl mo lasaxa nx *`Y> NonvHwaad (dod) iaM3HdoaoiH3viN3d,,?tk)j aaisai aaan sividaivw saois baij w isnonv `t>96i JP SYOS-IOS'dd 9*0N SY 10A*VHIV JO T JaWVSSM;Wi9aOUt3NON*MS NVWlSdOHl3NON`gr IMSM0M1IS ' SNOiivinwaoj iQNaHdoaoiKSYiNad omi io nviaaiYN aioia aioviivAv mvionaHMOO saij HsnouHi Noiivawdad ivNanor N39 SIS SMdai 013H sdoididosaa iovhisov 31V0 NI3IH0 Noiivniddv/Homnv xoarans ho aim 3dAi 1N3U0300 N0I1V301 31IJ HiflUnN NOISS300V 92 W31I 0661 HV3A H31A3H *J1 iaOIMOda 1ANIA si33dd3iNononaoad3a SUH31 013H *JU.I3IN3SViflU{JUI3INa90NI3tfVa fN3S0NZ3HV3 1YWXNV!NVUnH!aaia01H3 3N3GnANIA!3aiH01M3 1ANIA ******* SdOldldOSHQ 12 839W31d3S `9161 31V0 S93`0N Nliaiino iON39ni3iNI lN3ddna YHSO ONY*HSOIN NI9IH0 53NON* 3N0N NOXlVXIIddV/HOHinV A1X0XN390NI0HV0 SaailVH 1ANIA loarans ho aim NOIlVOIlOfld adAi iNaunooo N39 N0I1V301 31IJ ii\ bis HisunN NOISSaOOV S3 Haiti 0661 HV3A M3IA3H v*.r'tr:>; U3A!8Haifi4VHia3IH!SlVH!3XN0tiH3!AlI0IN390NI0HV0!N0IlV1VHNl ******* OHOldlHOSaO *S3IH01YHOOY1 1031-0X0 lYZHlSnONI IV 03100QNOO QNV (VOMIVMO AO OSdOSNOdS 3QIH01HO 1ANIA HIIN AQTU.S N011V1VHNX WH31-9N01 3HI 9NIQHV93H SNOIlVOINnUMOO ONV S1N3UON3WV lOOOlOHd 13YH1S0Y 9161 01 *161 3iva < `W3 H0d`S9V1 1031-0X0 IVIHlSnONI i 3N0N* 3N0N NXSIHO NOIlYXIXddV/HOHinV AQfUS NOXIVIVltfZ ltiai-9N01 MOA 3KL HOd N0IlV3XNniM03 ONV S1N3WQN3WV lOOOlOHd I33rans ho aim > 30N3QN0dS3dH00 3dAl 1N3MD00Q ii! N39 N0I1V301 31Id daOUHN NOISS333t - dt'ift r;I-.vj.V-. \ 066T HV3A H3IA3d laOifSiya!3INOl3tlll3IN3eONI3V3INOIlYlYWliWOA ******* SHOldltDSaa #v.'. v: >; ' = .. i:** -V '-. ' *sovi isai-oio CUllimdO S0 H1IH Y 138 311 39Yd XOO-TOO- 2XH-683SCI-130090 H38UTIN H30H0 S3N0T 1HV9 HOd inolNIdd if PRINTOUT FOR GARY ORDER NUMBER 660887-135859-NIZ - -001-08 ^ PAGE 113 SET .4 WITH MS OF'ME ' ''`"i ., /^REVIEW YEAR : " ^ ^ IMS O. ITEM 387 ACCESSION NUMBER FILE LOCATION 4'" DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR ^TEH 328 sr ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR ^JftEM 329 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 568 BEN JOURNAL , , gf, - -.. ... TWO CASES OF LIVER ANGI0SARC0H*M0NG FOllVlNYt* PRODUCING PVC BAGS AND OTHER CONTAINERS HALTONI C.NONEJCLINI CtNONEjflCINI F,NONE)HASINAANONEt NONE ,VOL 5 PP.897-30E) Jrh- 1984 W TWO CASES ARE REPORTED Of LIVER ANGIOSARCOMA OCCURRING AMONG POLYVINYL CHLORIDE (PVC) EXTRUDERS FROM A SMALL ITALIAN FACTORY PRODUCING PVC BAGS AND OTHER CONTAINERS. THE POSSIBILITY THAT PVC EXTRUSION CARRIES A RISK OF LIVER ANGIOSARCOMA IS IMPORTANT BECAUSE OF THE VERY LAR6E NUMBER OF PEOPLE WORKING WITH RUDXNG, MANUFACTURING AND HANDLING PVC, AS COMPARED WITH THE NUMBER OF PEOPLE WORKING IN POLYMERIZATIN ANO/OR VC PRODUCTION. IN THE PAST* THE LEVEL OF VINYL CHLORIDE (VC) CONC ATION IN PVC EXTRUSION WORKPLACES HAS BEEN POLYMERIZATION AMD/OR VC PRODUCTION. IN TH AST, THE LEVEL OF VINYL*THOUGHT TO BE rsiFE;" PVC{EXTRUSION* osarcoma; liver .............. -*itJ '**>**>' AMERICAN J OF TRIAL MEDICINE) V 1990 -k '* 557 , f*.w j , -'W. GEN ?1 JOURNAL OCCUPATIONAL ACROOSTEOLYSIS* REPORT OF 31 CASES < 4 WILSON RH,BF6MC CORMICK WE*SAME I TATltl CF*UNKNONN)CREECH;iLjtH(hOHN) *, 4-,. xim JAMA,VOL 201 PP.577-581) 1967, AUGUST 21 ;S ' '* *` IN 31 CASES OF ACROOSTEOLYSIS OF THE HANDS OF WORKMEN ASSOCIATED WITH VINYL CHLORIDE (CH2CHCL) POLYMERIZATION PROCESSES, THE OSTEOLYSIS HAS SPECIFIC TO THE DISTAL PHALANGES OF HANDS AND WAS FREQUENTLY ASSOCIATED WITH RAYNAUD'S SYMPTOMS. AFFECTED PERSONNEL RANGED IN AGE FROM 86 TO 47. THE DISORDER IS BELIEVED TO HAVE RESULTED FROM A COMBINATION OF PHYSICAL INSULT, CHEMICAL INSULT AND PERSONAL IDIOSYNCRASY. THE SPECIFIC CAUSES ARE UNKNOWN. THE PREVALENCE MAS FOUND TO BE LESS THAN 3/. AMONG EMPLOYEES PERFORMING SIMILAR WORK. NO CASES MERE POUIO IN WORKMEN USING OR PROCESSING THE POLYMER OR MANUFACTURING COMMERCIAL RESINS.*^ ACROOSTEOLYSIS;OCCUPATIONAL EXPOSUREJHAMJS,VINYL CHLORIDE^ RAYNAUD'S SYNDROME) l 1990 548 ' - 4 GEN JOURNAL CARDIOVASCULAR DISEASE AND ENVIRONMENTAL EXPOSURE ROSENMAN KD,NONE) r f 4$^'+ 1 A' i v.y J; v^ i-r* r>iwii 11 ron rtoy ' 'li./rv t:J I vf a PRINTOUT PGR GARY OROER NUMBER B60627-135259-WIZ , -001-001 PAGE 114 SET 4 WITH 365 OP 3BB ITEM* ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERNS COMMENTS REVIEW YEAR NONErVOL 3G >1**69-971 1979 ' S' ' THIS PAPER REVIEWS THE POSSIBLE ASSOCIATION BETWEEN CARD DISEASE,AND AXIONAL AW ENVIRONMENTAL AGENTS. THE, EFFECTS OF CARBON HONOftOEtPH METALS* NOSIE,RADIATION,HEAT,BOLD,SOLVENTS AND FLUOR CARBON Di; flfc.HEAVY^ 3ED.N0I3EJ1 iation*heAt, COLD,SOLVENTS AND FLUOROCARBONS ARE DISCUSSED.NEMURECtl ESTIGATION ARE GUfSESTEO. , ******* HEARTJCARBON MONOXIDE;DOSTJCARBQN OISULFIOEJNITRATESJ ium; lead;cobalt;mercury;ool61f vinyl chloride;noise;hypertension;methylene CHLORIDE; RAOiA' (Fluorocarbons;cigarette smoke atherosclerosis;hypocalcaenia;arrhythhia;polonium eio(electromagnetic radiation;lead eio; CARDIOVASCULAR DISEASE(GLYCERYL TRINITRATE; ETHYLENE GLYCOL DIMITRATEiEXPLOSIVES(CARDIOMYOPATHY; MOUNT SINAI SCHOOL OF MEDICINE;BRITISH J OF IWUSTRIAL MEDICINE; BLH( 641 GOOD GENERAL ARTICLE ON POSSIBLE ENVIRONMENTAL CAUSES OF HEART DISEASE WITH MANY REFERENCES CITED. - , -r^, 1969 ITEM 330 ACCESSION NUMBER 466 .v FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT ETHENE, CHLORO-* HOMOPOLYMER, (CAS6 9002-66-2HBFG TSCA INVENTORY SUBMISSION* FORMS A1E797336, AVON LAKE. *, *: t AUTHOR/AFFILIATION none*none; ORIGIN BFG-CHEMICAL* TO EPAI DATE 1978 ABSTRACT TSCA INVENTORY SUBMISSION OF 6E0N PVC RESINS. DOCUHENT IN CHfiM GROUP ENVIRON AFFAIRS DEPT FILES. DESCRIPTORS ******* TSCA INVENTORY;PVC HELD TERMS REVIEW YEAR CAS.NO. 9002-86-2! ETHENE,CHLORO-*HOMOPOLYMER I 1990 V. ' . `'V** /. -tv ,, ITEM 331 ACCESSION NUMBER 481 FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT ETHENE* CHLORO-, HOMOPOLYMER* (CASS 9002-86-2)* BF6 TSCA INVENTORY SUBMISSION, FORMS A12797395, PEDRICKTOWN. AUTHOR/AFFILIATION NONE,NONE 5 ORIGIN BFG-CHEMICAL* TO EPA; DATE 1978 ABSTRACT TSCA INVENTORY SUBMISSION OF 6E0N PVC RESINS. DOCUMENT IN CHEM GROUP ENVIRON AFFAIRS OEPT FILES. DESCRIPTORS ******* CAS.NO.9002-86-2;TSCA INVENTORYJPVC REVIEW YEAR 1990 *ITEM 332 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT GEN v*- REPORT ETHENE* CHLORO-, HOMOPOLYMER* (CASS 9002-86-2)1 BF9 Y SUBMISSION* FORMS A12797163, g 5204 -c % r^TtumiT rnR BftRY I0NP9 >>-- i. n i 1 r PRINTOUT FOR CARY JONES ORDER NUMBER 860627-135259-WIZ >001-001 PACE 115 SET 4 WITH MS OF LOUISVILLE. AUTHOR/AFFIUATI0N - NONE>NONESi ORIGIN BFG-CHEMXCA DATE 1975 ABSTRACT TSCA INVENTORY DESCRIPTORS ******* CAS.N0.9002-66-E REVIEW YEAR 1990 ITEH 333 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS REVIEW YEAR 979 GEN REPORT -S; =.>#, '' ETHENE, CHLORO-, HOMOPOLYMER* (CAS 9002tB6-2) * 8F6 TSCA INVENTORY SUBMISSION, FORMS A12797163, LOUISVILLE. NONE,NONE! BFG-CHEMICAL, TO EPA; 1970 TSCA INVENTORY SUBMISSION OF 6E0N PVC RESINS. DOCUMENT IN CHEN CROUP ENVIRON AFFAIRS DEPT FILES. REPORT OF IMPORTED PVC. t J. , CAS.NO.9002-66-2!TSCA INVENTORY; PVC ^-* 1990 ITEM 334 ACCESSION NUMBER FILE LOCATION GEN - >" "X DOCUMENT TYPE TITLE OR SUBJECT REPORT *. ETHENE, CHLORO-kHOMOPOLYMER^TCASS 900ft?C*<rt ) t WPC SUBMISSION, FORMS M279740i, LONG BEACH. '* *\ < * v A -V* AUTHOR/AFFILIATION NONE,NONE; ' *\ ORIGIN BFG-CHEMICAL, TO EPA; DATE 1978 -. ABSTRACT TSCA INVENTORY SUBMISSION. DOCUMENT IN CHEM CROUP ENVIRON AFFAIRS DEPT FILES. DESCRIPTORS ******* CA5.NO.9002-66-2JTSCA INVENTORY;POLYVINYL CHLORIDE < U)L REVIEW YEAR 1990 ITEM 335 ACCESSION NUMBER 473 FILE LOCATION GEN :-s DOCUMENT TYPE REPORT "? :A TITLE OR SUBJECT ETHENE, CHLORO-, HOMOPOLTMER, (CAS* 9002-86-2)* BFG 'AUTHOR/AFFILIATION HENRY. none,hone; , ft. . ^ ' <* #r. V ORIGIN DATE BFG-CHEMICAL, \TO EPA! 1976 ' * ABSTRACT TSCA INVENTORY SUBMISSION OF CEON PVC RESINS* DESCRIPTORS ******* CAS.N0.9002-66-E|TSCA INVENTORY! PVC REVIEW YEAR 1990 Y SUBMISSION, FORMS A12797296, fa?' i. CROUP ENVIRON AFFAIRS DEFY FILES. 20838116 PRINTOUT FOR GARY JONFS -7T- r" .. > 1 If S' - PRINTOUT FOR GARY JONES ORDER NUMBER 660627-135259-HIZ -OQl-OOl PAGE U6 SET 4 WITH 365 OF 3*5 ITERS * f' ITER 336 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ****** REVIEW YEAR 472 4 > ' GEN ~ '* REPORT ETHENE, CHLORO-* HOMOPOLTMEfl J1 (CAS# 9002-**-2fl SUBMISSION, MRHtlUE7^73tf; CLEVELAND. NONE,NONE*, BFG-CHEMXCAL, TO EPAJ 5 1978 ' N\ TSCA INVENTORY SUBMISSION OF GEON PVC RESINS. DOCUMENT IN CUtH tfeOUPENVIRON AFFAIRS DEPT FILES. RECORD OF PVC IMPORTED. * tV > : CAS.NO.9002-66-2}TSCA INVENTORYtPVC ? t. ' 1990 ITEM 337 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ****** REVIEW YEAR 470 ' v;-4* CGEN REPORT ETHENE, CHLORO, (CASS 75-01-4)* BFS TSCA INVENTORY SUBMISSION, FORMS A12797346, CALVERT CITY. NONE,NONES ;; BFG-CHEMICAL, TO EPA} 1976 TSCA INVENTORY SUBMISSION OF VINYL CHLORIDE. DOCUMENT IN CHEMICAL GROUP ENVIRON AFFAIRS DEPT FILES. CAS.NO.75-01-4STSCA INVENTORY!VCN 1990 '*=- ITEM 330 ACCESSION NUMBER 457 FILE LOCATION GEN DOCUMENT TYPE REPORT TITLE OR SUBJECT CHLORINATED POLYVINYL CHLORIDE, (CASS 66646-62-6): BF6 TSCA INVENTORY SUBMISSION, FORKS C31447139. LOUISVILLE. AUTHOR/AFFILIATION NONE,NONE! ORIGIN BFG-CHEMICAL, TO EPA! DATE 1978 ABSTRACT TSCA INVENTORY SUBMISSION. DESCRIBED IN TSCA INVENTORY AS ETHENE, CHLORO-, HOMOPOLYMER CHLORINATED. DOCUMENT IN CHEM GROUP ENVIRON AFFAIRS DEPT FILES. DESCRIPTORS ***#*# CAS.N0.68646-62-6!TSCA INVENTORYCHLORXNATED POLYVINYL CHLORIDE REVIEW YEAR 1990 ITEM 339 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE 456 GEN REPORT iSKfr- j '. 20898117 rmiT rnn rny ihmf*: 2089*3118 PRINTOUT FOR GARY,JONES ORDER NUMBER 6608Z7-135259-HIZ -OOl-OOl ij-fe PAGE 117 SET 4 KITH 305 OF 3SS STEMS TITLE OR SUBJECT CHLORINATES POLYVINYL tHLORIOl, (CASt C3141002Q, LOUISVILUl. v AUTHOR/AFFILIATION NONE,HONE} ORIGIN BFG-CHEMICAL, TO ERAS DATE ABSTRACT 1976 r TSCA INVENTORY SUBMISStONi<ifciteCCL2)H, DOCUMENT DESCRIBED IN TSCA INVENTORY AS ETHENE* CHLORO-i DESCRIPTORS *#** CAS.N0.6664B-BE-8ITSCA INVEHTORYJCHLORINATIO POI.YV1NYL CHLORIDE REVIEW YEAR 1990 ITEM 340 ACCESSION NUMBER 448 FILE LOCATION GEN DOCUMENT TYPE BIBLIOGRAPHY TITLE OR SUBJECT VINYL CHLORIDE AND INYL CHLORIDEi TOXICOLOGY 11976-19831 - CITATIONS FROM THE LIFE SCIENCES COLLECTION DATA AUTHOR/AFFILIATION NONE,NONE} ORIGIN NONE,PB84-85541 } DATE 1964 DESCRIPTORS ******* VCM;PVC;EPlO&1IOLOGVICANCER?BIRTH DEFECTS}MUTAGENICITY,REPRODUCTION* HETABOLISMJTOXlCITY OATA HELD TERMS NTIS REVIEW YEAR 1990 ITEM 341 ACCESSION NUTBER 442 .. ' '"V FILE LOCATION GEN * ' - I DOCUMENT TYPE REPORT iV TITLE OR SUBJECT 2-BUTENEDIOIC ACID CZJ-OIETHYL ESTER, POLYMER HXTH CHL0R00E1HENE AN) ETHCNYL ACETATRjr (CASt 65072-3B-0>*. BFG TSCA INVENTORY SUBMISSION, F0RM#B21443724,U>U1SV21U. AUTHOR/AFFILIATION NONE,NONE5 ' >'/ 5*- H,.'- ORIGIN BFG-CHEMICAL, TO EPA, '- DATE 1978 .. ABSTRACT TSCA INVENTORY SUBMISSION OF GEON 450X10 AND GEON 4SOXll (C6Hl204.C4H602. C2H3CDX; DOCUMENT IN CHEM GROUP ENVIRON AFFAIRS QEPT FILES. DESCRIPTORS ******* CAS.NO.65072-3Q-05TSCA INVENTORYJGEON 450X1056E0N 450X11 REVIEW YEAR 1990 ITEM 342 ACCESSION NUTBER FILE LOCATION DOCUMENT TYPE `TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT i393 GEN JOURNAL CHEMICAL ASPECTS OF THE TXONSHIP BETWEEN DR EFFECTS: AN OVERVIEW WESTEfttDRF JR,NO artfLETON^AC,HONE; NONE,VOL 71 PP.4 2U ? 1979, AUGUST '` ' $ THIS ARTICLE 0*4 ES HATER HARDNESS AND CARDlttfASCU AM) LONG-TERM i MORtAUTY RATES^10ICAL DATA ' i -- ^ ,\ % f . *: ` 20838118 $ as;: '," . '>' , 3 prUHTnilT rtlP PAPY YOHr* 20308119 PRINTOUT FOR CART ORDER NUMBER 860U7-135259-HIZ \ -001-001 PAGE 118 SET 4 WITH 38S OP iKtf Xt|HS DESCRIPTORS HELD TERMS REVIEH YEAR (BLOOD DATA I, AND METALS ARE DISCUSSED. THEDATA ALSO SHOWS THAT RESIDUAL IN METAL VERSUS PVC PIPE (RES PVC;CHLORINE }PVC. PIPE JMWTA POTABLE HATERSMETALSSMEtAt 1989 ' ?' ITEM 343 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS COMMENTS REVIEW YEAR 390 GEN REPORT PRELIMINARY SURVEY OF CHEMICAL COMPOSITION,CONTAftlMATlOH AMfr PIPE FOR POTABLE NATER SUPPLY; NONE.none; NONE I960. NOVEMBER 14 A PLUMBERS UNION SUPORTED$*EPORT ON ALL POSSIBLE INGREOIENTS/ CONTAMINANTS IN PLASTIC PIPE. THIS IS MORE SPECULATION THANjkCT, BUT MAS INTENDED TO CONVINCE CALIFORNIA REGULATORS OF A NEED FOR AN EIR (I.E. KEEP PLASTIC PIPE FROM INCREASING USE IN THE STATE). pvc;cpvc;rzsk assessment;contaminants PLUMBERSiPOTABLE HATfRjPLASTIC PIPE THOMAS REIO ASSOCIATES(POLYBUTYLENE;POLYETHYLENEt RKHC84I GARBAGES 1986 ITEM 344 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT w- ,Vt! ;';H 389 GEN ;:tv REPORT FINAL REPORT ON POTENTIAL HEALTH-HAZARDS ASSOCIATED HXTH tHE USE OF FUSTIC FIFE ZN POTABLE MATER SYSTEMS NONE.none; NONE 1980. OCTOBER 17 THIS FINAL HAZARD ASSESSMENT IS BASED ON STUDIES MHXCH INDUSTRY AGREED TO SPONSOR. THE LACK OF ADEQUATE METHODOLOGY AND 4INI0N PRESSURES PREVENTED RESOLUTION OF HEALTH ISSUES RAISED BY THE DESCRIPTORS HELD TERMS UNION. THE REPORT FAILEJfTO FIND ANY PROBLEMS, BUT EQUIVOCATED ENOUGH TO OPEN UP THE QUESTION OF A NEED FOR AN EIR. # ******* solvents;pvc;cpvc;mowers;effects ;mek;thf LEACHING;PLASTIC PipjfiPOTABLE WATER.VOLATILE 0R6ANICS;METALSJABS! PERSONAL MONITORZNGIPLUMBERS; REVIEH YEAR D1METHYLF0RMAMIDE;CYCL0HEXAN0NE; CALIFORNIA DEPT OF HEALTH-SERVICES! 1989 . -r. ITEM 345 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 388 GEN GOVERNMENT CORR SAFETY OF PLASTIC Jb Sm lift PES FOR USE IN POTABLE HATER DISTRIBUTION v-APDTMTfflfT FOP GARY .tOMFS r. "jpf-ji:.. & PRINTOUT FOR GARY JONES ORDER NUMBER 860827-135259-HIZ PAGE 119 SET 4 NITN 345 OF'36# AUTHOP/AFFILIATIOH 9* HANSON HPERA) , ; origin epA.ro Br&aiam* DATE ABSTRACT DESCRIPTORS HELD TERNS REVIEW YEAR IHHHHH*# 1982 ; : * .f ERA POSITION EPAJPVC1VINYL PLASTIC PlPEt 1986 ITEM 396 ACCESSION NUMBER 387 FILE LOCATION GEN DOCUMENT TYPE PAPER TITLE OR SUBJECT USE OF METAL AND PLASTIC PIPES IN MATER SUPPLY DISTRIBUTION SYSTEMS AUTHOR/AFFILIATION LASSOVASKY PEPA.KHAN T.SAHE} ORIGIN EPA DATE 1981 ABSTRACT EPA POSITION PAPER LASTTC PIPE AND THE OCCURRENCE OF DEHP (PLASTICIZER). ALSO DISCUSSED DISCONTINUATION OF L PIPE DUE TO HEAVY METAL PROBLEMS. DESCRIPTORS ******* EPA.OEHP.VINYL CHU DE1PVC * -v.?*vK HELD TERMS PLASTIC PIPE {POT, NATER {METAL PIPE{LEACHING* i '; REVIEW YEAR 1986 ITEM 397 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT 362 GEN REPORT /f SOLVENT LEACHING FROM POTABLE HATER PLASTIC PIPES: FINAL', REPORT AUTHOR/AFFILIATION NONE.none; / ORIGIN NONE.BY JAMES M.MONTGOMERY LTING ENGINEERS} DATE 1980. OCTOBER 6 ABSTRACT THIS WORK WAS SPONSORED BY BCUSTRY AND IS THE BASIS FOR THE bCTOBER 17. 1960. REPORT "FINAL REPORT FOR PVC AND CPVC PIPE.STUOY. DESCRIPTORS ******* PVC{CPVC{SOLVENTS{MEKiTHFi HELD TERMS leaching;plastic pipe;met, }VOLATILE ORGANICS{POTABLE HAtER{ CYCLOHEXANONE{DIMETHYLFORMAMIDE{ ABS REVIEW YEAR 1989 ITEM 396 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE 'TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ****** 379 GEN TECHNICAL HAZARDS EVALUATION A RISK NONE.none; NONE.BULLETINS HE-145-1 1989. MARCH DETAILED FLAMMABILITY VINYL CHL0RIDE1ACR0LEII ol services Data Guides ** (AMS ON VARIOUS CHEMICALS. rADXENE {DIOXAHE {KAPHTittUNB :0i If o 00'* -n P rni'irniir rnp rivpy inHF? #-* / 1 PRINTOUT FOR BART ORDER NUMBER 660327-135259-MIZ . >001-001 PA6E 120 SET 4 WITH MS 0F S3S ITEMS - HELD TERMS REVIEW YEAR ITEM 349 ACETALJALLYL ALCOHOLIISOAMYL ACETATEfAWYL ALCOHDL1BUTTL PENTENE;CYMENE)ETMYLENECMLOROMYORINCHUJROBEMZQ0II FLAMMABILITY! HERCULES INC! 2059. i rlpIETHTLAMINff " ^NETWfl >4sW ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELO TERMS REVIEW YEAR 375 GEN PUBLICATION HEALTH HAZARD EVALUATION/TOXICITY DETI KT1W, HATER HELL SftttLlNG COMPANIES* WESTERN TENNESSEE I REPORT NO. 75-163-309) GULES DNIOSH{HATCH L.NIOSH5 NIOSH,REPORT NO.TP-HHE-75-163-309; 1976 JULY ON THE BASIS OF MEDICAL AND ENVIRONMENTAL DATA COLLECTED AT THE HATER HELL DRILLERS IN WESTERN TENNESSEE* THE USE OF POLYVINYL CHLORIDE (PVC) CEMENT IS NOT FOUND TO CONSTITUTE A HEALTH HAZARD UNDER EXISTING CONDITIONS OF USJTT ENVIRONMENTAL SAMPLES SHOW ONLY LOW LEVELS OF TETRAHYDROFURAN AND NO DETECTABLE LEVELS OF CYCLOHEXANONE. RESPONSES TOMEDICAL QUESTIONNAIRES ItCICATE NO SYMPTOMS ASSOCIATED WITH EXPOSURE TO THE CHEMICALS. pvc;cements;solventsthf;detJ1mination;niqsh CYCLOHEXANONESHATER HELLSiPgMBLE HATER! PERSONAL MONITORINB!.- 1939 Mr- ITEM 350 ACCESSION NUMBER 374 FILE LOCATION GEN DOCUMENT TYPE PLANT CORR TITLE OR SUBJECT WILGZNG HOME STUDY AUTHOR/AFFILIATION KOEBEL RF BFG-AVON LAKE! ORIGIN BFG-AVON LAKE >TO BFGrCHEMICALJ DATE 1961t DECEMBER 22 .'H ABSTRACT VOLATILE ORGANIC SAMPLING OF POTABLE HATER FROM A 6 MONTH OLD CPVC PIPE SYSTEM IN A HONE *******DESCRIPTORS <R.WILGING) IN AVONaAKE. cpvc;analysis;chlqroform;carbon tetrachloride HELD TERMS VOLATILE ORGANICS!LEACHING5CPVC PIPE* REVIEW YEAR 2059 f ITEM 351 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE DESCRIPTORS ******* HELO TERMS 350 GEN PUBLICATION / TETRACHLOROETHYLENEJCONTAMINATION OF DRINKING HATER BY VINYL WAKEHAM SG,NONE?0AS AC,N0NE|M1TT RT,N0NjTRIP*BH*N0!4jP*! NONE*VOL 25 PP.6399645; I960 # ', . 'f. v TED ASBIST03-CEMEHT PIPE H0NE! *. fr ; PVC; TETRACHL0R0E1HYLENE ' ASBESTOS-CEMENT JlPE (ORTWINS MATER! BULLETIN OFENVIR t. Contamination a toxicology; * r-mtiTMUT rnR CARY IONF9 'O 4 PRINTOUT FOR BART ORDER NUMBER 660827-135259-HIZ PA6E 121 SET. 4 KITH 305 OP REVIEW YEAR . iw&t ITEM 352 s' . rM'-i 'S ACCESSION NUMBER r- FILE LOCATION DOCUMENT TYPE 341 GEN REPORT TITLE OR SUBJECT PRELIMINARY STUOY ON STEEL PIPING SYSTEMS ' AUTHOR/AFFILIATION NONE.NONE} ORIGIN NSF DATE ABSTRACT 1980. SEPTEMBER COPPER,GALVANIZED,AJ# PLASTIC PIPE HERE STUDIED TO DETERMINE, THE METALS UtlCti HERE ifACHED. EXCESSIVE LEVELS OF jfiPPER,LEAD,TIN, AND ZINC MERE EXTRACTED FROM METAL PIPE. DESCRIPTORS **** PVC m. HELD TERNS POTABLE WATER .HETmI} LEACHING; PLASTIC PIPE {COPPER PIPE'.GALVANIZED PIPE; ITEM 353 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 339 4* GEN '~ PAPER MONITORING FOR TOXICOLOGICAL SAFETY -5 HC CLELLAND MI,NSF. NONE,INTERNATIONAL CONFERENCE NEH ORLEANS) '** * 1961 /f ' ' IN THE U.3, MONITORING FOR TOXICOLOGICAL SAFETY OF FUSTIC PIPING SYSTEM COMPONENTS IS ACCOMPLISHED BY THE NATIONAL SANITATION FOUNDATION (NSF) THROUGH A VOLUNTARY PROGRAM OF TESTING AND LISTING UNDER NSF STANDARD 14 IPLES: COLLECTED DURXNKitMAlfHXJNCED VISITS TO PRODUCTION FACILITIES ARE TESTED FOR EXTRACT] OF POTENTIALLY TOXIC CffEHfCAl SUBSTANCES. IN ACCORDANCE WITH , REQUIREMENTS IN THE STANDARD.IH DITION, RVCM IS HEASUREDItf THE HALL OF PVC AND CPVC PIPE ANO FITTINGS. TEST PROTOCOLS, INGREI NT REVIEW PROCEDURES, AND RECENT RESULTS ARE PRESENTED. THE s' LOGO (NSF-PM) ON A PRODUCT,PIPl FITTING, IS ASSURANCE THAT THE PROOUCT HAS BEEN 'TESTED ANO FOUND TO CONFORM WITH ALL ST; 14 REQUIREMENTS FOR POTABLE HATER APPLICATIONS, PVC;CPVCTESTING.ANALYSIS 5NSI ;:'f` -rV? : PLASTIC pipeirvcm; ASCESAMEI SOCIETY OF CIVIL ENGINEERS};NSF SID B14S v 1987 V ' ` , JUT S $* ITEM 354 ACCESSION NUMBER 329 FILE LOCATION GEN DOCUMENT TYPE RESEARCH LAB REPORT TITLE OR SUBJECT ENVIRONMENTAL REVIEW OPOSED EXPANDED USES OF P lONElNG PIPE AUTHOR/AFFILIATION NONE.none; ORIGIN NONE,PROJECT NO.HSH DATE 1963, MARCH ABSTRACT THIS IS THE ENVIR REVIEW ON THE PROPOSED EXPANDEOUSfcfifr PLASTIC PIPE IN CittrORNIAL IT HILL BE INCORPORA IN AN ENVIROWttNTAL IMPACT*REPORT. V- DESCRIPTORS ** PVC;WORKER; toxicologt: ..sy , f p-t ft'# ; & i( S'. ' K*- I'fMi'innr rpo c*ipy in'irs - ro 004 PRINTOUT FOR GARYJCNCS ORDER NUMBER 660627-135259-HIZ >001-001 J PASS 122 SET 4 WITH 385 OP *8* ITEMS HELD TERMS REVIEW YEAR ITEM 355 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AF FILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ** HELD TERMS PLASTIC PIPE)EIR)PLUMMR5l 1986 ' '' ' v 323 GEN REPORT OCCUPATIONALLY-RELATED INJUR] AND ILLNESSES OCBJRRING fcHBNB NLUMBERS,PIPEFITTERS STEAM-FITTERS IN CALIFORNIA-] '~ NONE,NONE: LASSITER DV,I NONE 1963, FEBRUARY 16 A LOW INCIDENCE OP CANCE* AT ALL SITES WAS FOUND IN A COHORt OP PLUMBERS, PIPEFITTERS,AMJ STEAM FITTERS. THE AUTHOR WAS^CONSULTANT REPORTING FOR THE STATE OF CALIFORNIA (SRI CONTRACT/EIR ) EPIDEMIOLOGY SPVCiCPVCMRLVENTS: EFFECTS (CANCER {WORKER ,, PLUMBERS!EIR{CEMENTS;PLASTIC PIPE{ DONALD V. LAS8ITER CONSULTANT) ITEM 356 v;> '.vKv. ACCESSION NUMBER 319 FILE LOCATION DOCUMENT TYPE GEN REPORT *n TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DIFFUSION OP ORGANICS FROM NONE,NONE: NONE PIPE (PINAL REPORT) [W 'r DATE 1962, SEPTErBER ABSTRACT THIS IS THE FINAL REPOR THE DIFFUSION OF ORGANICS FROM CPVC.PIPE. THIS WORK WAS SPONSORED BT BFG TO AODRESS QUESTI AISED DURING THE CALIFORNIA ENVIRONMENTAL IMPACT REPORT (EIR) ON PLASTIC PIPE. DESCRIPTORS ******* CPVC{ANALYSIS HELD TERMS CPVC PIPE{VOLATILE ORGANIC ANALYSIS{LEACHING; JAMES M. MONTGOMERY CONSULTING ENGINEERS; ITEM 357 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 313 GEN RESEARCH LAB REPORT STUDY REVIEW: PRESENCE OF CHEMICALS ASSOCIATED WITH PVC/CPVC PLASTIC PIPE IN POTABLE WATER NONE,none; NONE,FOR CALIFORNIA PIPE TRADES COUNCIL) 1980, SEPTEMBER REPORT SPONSORED BY THE PLUMBERS,UNION ON ALL POSSIBLE CHEMICALS THAT MIGHT BE USED IN PLASTIC PIPE SYSTEMS. IT HAS INTENDED SPECULATION THAN FACT. INCE CALIFORNIA THAT.;OUft: EIR HAS NEEDED. THIS REPORT IS MORE 5* pvc;cpvc;mek;thf;contaminants PLUM8ERS{EIR{CYCLOHEXANONE{0 THYLFORMAMIDE;PLASTIC PIPeM^IXFORNIA ANALYTICAL LABS) 1986 $***. rniMrnriT rnp f^PY IOHF* 2033iJl21 PRINTOUT FOR BART ORDER NUMBER 660B27*135259-MIZ " PAGE 123 SEt 4 KITH 465 Of ' ;-Vv' * ITEM 356 ACCESSidn NUMBtir;^- FILE LOCATION &rh BEN > DOCUMENT TYPE "> PLANT CORR TITLE OR SUBJECT EXTRACTION OF AUTHOR/AFFILIATION DE CAPITA E6>BF8*AVQN ORIGIN BFG-AVON LAKE,TO BF DATE 1980, MARCH 21 ABSTRACT AN ANALYTICAL REPO ANALYSIS AND CALIBR DESCRIPTORS ******* SOLVENTSTHF; MEI HELD TERNS POTABLE HATERfC ITEM 359 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEN YEAR ****** ITEM 360 309 GEN PLANT CORR PILOT PIPE STUDY HINOERER RK,BFG-AKRON} BFG-AKRON,TO BFG-CHEMICALl 1963. FEBRUARY 25 PILOT STUDY SPONSORED BY, E PLUMBERS UNION TO RAISE AN ISSUE THAT PLASTIC PIPE COULD BE PERMEATED BY CHEMICAL-C AMINATED SOIL ANDiTKEREFORE* PQSEAHAzARD TO THE PUBLIC*. METAL PIPE* INTERESTINGLY, ALSO SHOpS SOLVENT PERMEATION, - pvc; trichloroetoane ;Solvents; POTABLE HATER } PLASTIC ,PIPE (PERMEATION(DZCHLQROPROPANE 1966 v$!" ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ........... .. HEU) TERMS REVIEH YEAR 307 GEN RESEARCH LAB REPORT LITERATURE REVIEH OF THE POTENTXALrttAZARDS TO HUMAN HEALTH' POTABLE HATER DISTRIBUTION none,none; * j' .fa SOUTHERN RESEARCH INSTTnfTE3flRl'EAS-B3-l65} j ' s ... 1963, FEBRUARY M A LITERATURE REVIEH OF POTENTIAL HEALTH HAZARDS OF PVC AtO CPVC PIPE FOR POTABLE KAfER USE. THIS IS NOT TERRIBLY HELL DONE.jfT HAS SUBMITTED TO J OF AMERICA^ HATER MORKS ASSOC (R WILGING, IT HAS SUBMITTED TO J OF AMERICAMftlATER MORKS ASSOC (R.MUSING,+REVIEHER), PUBLICATION STATUS IS UNKOHN. PVC CPVC; ACUTE! EFFECTS SJvDCHRONIC; SOLVENTS (HIfiB?ATION;FETALTOXICITY; BENZENE t ACRYLONITRILE} TOLUENE;mutagenic;terat( ic;carcinogenicity; vinyl chloride,chloroform;tetrachloroCthylene} TRICHLOROETHYLENE; DICHI ETHANE .CARBON TETRACHLbRiOESTRXtHLOROETHANE ISTYRENEI HETWtL; METHACRYLATE;DEHP}THF} I iCHLORlMEiKYOROGEN CHLORIDE; CEMENTS5METHYL STYREN| rLEACHING;PVC PIPEfP ^TITANIUM DXOXXOB. -P 1966 *jk .*' pr* mini if rnp GARY JONFS PRINTOUT FOR 6ARt J0NM ORDER NUMBER G6QBE7-135E59-WIZ r -001-061 /-N PAGE 1E4 SET 4 MITH 36S OP. HE ITEMS ITEM 361 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS ****** HELD TERMS 306 GEN PUBLICATION ORGANIC AND ORGANDT] BOETTNER EA,EPA;BAL( EPA , EPA-600/S1-81-I _________ )S LEACHED PfeoM PVC AND CPW Ml >LEPA}HOLLIN6SMORTH Z.EPAiAQUINO R*EPAf ' .V; frti 1982, FEBRUARY / . LEVELS OF ORGANOTlNS LEACHED HERE VERY LON CPPT TO PPB). MEKtHF AND CYCLOHEXANONE SOLVENTS LEACHED FROM SEALING CEMENTS HERE HIGHER <10 PPB TO 10 PPM). " PVC;CPVC;ORGANOTINSJTHFJMEK ' .. PLASTIC PIPE] LEACHINGiCYCLOHEXANONEl v ITEM 362 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 303 GEN REPORT PPFA COMMENTARY ON LEACHING OF TOXIC AND CARCINOGENIC CHEMICALS INTO DRINKING HATER REQUIRES PREPARATION OF AN EIR AND ON THE PRELIMINARY SURVEY OF CHEMICAL, COMPOSITION,CONTAMINATION*AND ASSOCIATED HEALTH HAZARD OF PLAStlC PIPE FOR POTABLE HATER NONE.none; none,none; 1981, JULY 1 ALTHOUGH THE CALIFORNIA HOUSING AND COtflUNITY DEVELOPMENT COMMISSION HAS REQUESTED AN EIR, THE REID REPORT AND ADAMS TESTIMONY SUBMITTED TO THE COMMISSION Bt LOCAL 467 OF THE PLUMBERS AND STEAMFITTERS UNION ("UNXflfP1) SHOULD BE DISCOUNTED AS EVIDENCE FQR THE NEED FOR OR SCOPE OF AN EIR FOR PLASTIC PIPE BECAUSE^THEY FAIL TO MEET THEIR OWN CIRTERIA OF "SUBSTANTIAL EVIDENCE" AND ARGUABILITY FOR ENVIRONMENTAL HARM. NEITHER SHOULO THEY BE CONSIDERED AS VIABLE EVIDENCE SUPPORTING THE UNION'S ^UNJUSTIFIED EFFORTS TO RESTRICT THE USE OF PLASTIC PIPE. pvc;cpvc;effects;plas1?c plastic pipe;environiental impact report;plumbers; ppfajleaching; POTABLE hater; 1986 ITEM 363 ACCESSION NUMBER 295 >' FILE LOCATION GEN DOCUMENT TYPE NIOSH REPORT TITLE OR SUBJECT HEALTH HAZARD EVALUATION REPORT^PLUMBERS AND GASFXTTER3 LOCAL UNION IE BOSTON,MA. AUTHOR/AFFILIATXON NONE,none; dr ORIGIN NIOSH,H.H.E. REPORT Nd.Bl-336; jT *v 'date 1982 ' ' ABSTRACT NIOSH CONDUCTED A QUESTIONNAIRE SURVEY,PERSONNEL MONITORING,AND MEDICAL EVALUATIONS OF PLUMBERS THAT NORKED MITH PVC CEMENTS AID CLEANERS. NO EXCESSIVE SOLVENT EXPOSURES, NO IMPAIRMENT OF BRAIN FUNCTION, AND NO CHRONIC DISEASE MAS FOUND,ALTHOUGH DIZZINESS,HEADACHES, EYE AND SKIN IRRITATION AND TINGLING IN THE FINGERS4KRE REPORTED IN THE QUESTIONNAIRE* ir -v DESCRIPTORS **** PVC{BRAINEFFECTSIMEK; THF uBEMENTS.CHRONIC * 80898125 11111 m r r Af>v it"^ 2C89*.L2fi PRINTOUT FOR ART ORDER NUMBER 860827-135259-HIZ -OOl-OOt PAGE 125 SET 4 HITH 385 OP 30* HEM* HELD TERNS PERSONAL MONITORXtoiti r\ : ACCESSION NUMBER 893 FILE LOCATION GEN DOCUMENT TYPE PUBLICATION ... ^ TITLE OR SUBJECT HEALTH HAZARD EVALUATEON/TOXlClTY OETEPHINAtlOtfVEEraRTi AUTHOR/AFFILIATION GUNTER BJNIOSHtLUCAS JB,NIOSHt ' ORIGIN NIOSH,REPORT NO. H.H.B. 74-61-232t DATE 1975, NOVEMBER ^- ABSTRACT A PLANT MANUFACTURING EXTRUDED HOSE, PRINCIPALLY FROM THE EXTRUSION OP POLYVINYL CHLORIDE, HAS INVESTIGATED BY NIOSH TO EVALUATE EMPLOYEE EXPOSURES TO CYCLOHEXANONE, TDI,TRICHLOROETHYLENE, ESTANE R THERMO- PLASTIC POLYURETHANEi METHYLENE CHLORIDE,NI9ROSINEDI-2-ETHYL HEXYL PHTHALATE (DOP OIL), OUST,AND VINYL CHLORIDE. IT WAS DETERMINED THAT A POTENTIAL HEALTH HAZARD MAY EXIST FROM EXPOSURE TO CYCLOHEXANONE ,AND THAT SEVERAL CASES OF ntIHARY IRRITANT DERMATITIS HAD OCCURRED FOLLOWING REPEATED EXPOSURE TO SOLVENTS. ALTHOUGH ONLY ONE OF 38 VINYL CHLORIDE SAMPLES HAS FOUND TO EXCEED THE FEDERAL STANDARD ACTION LEVEL, IT HAS RECOMMENDED THAT AIRBORNE CONCENTRATIONS BE REDUCED TO LEVELS NOT DETECTED BY THE RECOMMENDED ANALYTICAL TECHNIQUES. DESCRIPTORS mumwim PVCjCYCLGHEXANE)TOLUENE DIISOCYANATE 5TRICHLOROETHYLENE5 PLASTICS;METHYLENE CHLORIDEJUEHPJVINYL CHLORIDE5DERMATITISJPATCH TESTEXTRUSION HELD TERMS PERSONNEL MONITORING; ESTANE;NIGR0S1NESDI-E-ETHYL HEXYL PHTHALATE; ITEM 365 ACCESSION NUMBER 285 ! *< % ZMX FILE LOCATION GEN DOCUHENT TYPE REPORT TITLE OR SUBJECT ACRYLIC ACID, TRIESTER HTTH t-ETHYL-8-(HYOROXYWIhYL)-l,fcpROPAMOIOl POLYMER WITH BUTYL ACRYLATE, (CAS* 25119-93-1): DFG TSCA INVENTORY SUBMISSIQNrPORH* B21464284, AVON LAKE* AUTHOR/AFFILIATION NONE,NONE) ORIGIN BFG-CHEMICAL. TO EPA; *k ' DATE 1978 ABSTRACT TSCA INVENTORY SUBMISSION OF GEON 300X13, RIGID COPOLYMER. LISTED IN TSCA INVENTORY BY CAS* AS 2-PROPENOIC ACID, BUTYL ESTER, POLYMER MITH 2- ETHYL-2-(((1-OXO-2-PROPENYL)OXTJMETHYL)-I, 3-PROPANEDIYL DI-2-PROPENOATE . IC15H2006.C7H12021X. DOCUMENT IN CHEM GROUP ENVIRON AFFAIRS DEPT FILES. f-i DESCRIPTORS ******* TSCA INVENTORY ;AA TRIESTER ETHYL(HYDROXYMETHYLJPGOPANEOIOL POLY U/BUACRYLAT, CAS.NO.25119-93-1J GEON 300X13 REVIEW YEAR 2059 . a. - ITEM 366 '4 .ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFIIIATION ORIGIN 281 i* GEN REPORT ACETIC ACID, ETHENYL ESTER, POLYMER HITH CHLOROCtHENEj SUBMISSION, FORM * AI2797163, -LOUISVILLet vyr NONE,NONE; . !:' r -Vf1 BFG-CHEMICAL, TO EPAS Y- W&3-22-9): BFG TSCA-INVENTORY mrurnirr Fnr? raoy JONFS '> r &H* 'T 203^dl27 t iSStVj BFG52816 PRINTOUT FOR GARY ORDER NUMBER 660627-135259-HIZ PADS 126 . SET * HITH 5 Of DATe ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR TSCA INVENTORY SUBMISSION 135X6E 421, 427,426, 440X38k ******* GEONSJTSCA INVENTORY SQEOM 42KGEON 427SGE0N 426J6E0N CAS.NO.9003-22-9; 2059 ITEM 367 ACCESSION NUMBER 260 - FILE LOCATION GEN r' DOCUMENT TYPE TITLE OR SUBJECT REPORT ACETIC ACID, ETHENYL ESTER, POLYMER WITH CHLOROETHENE AND N-IHYDROXTMETHYLI- 2-PROPENAMIOE, (CAS965045-74-1): TSCA INVENTORY SUBMISSION, FORM 2-PROPENAMIOE (CAS965045-74-1): BFG TSCA INVENTORY SUBMISSION, FORM 0+B21463732, AVON LAKE. AUTHOR/AFFILIATION NONE,NONE* v - *, * r' ORIGIN BFG-CHEMICAL,TO EPA; DATE 1976 ABSTRACT TSCA INVENTORY SUBMISSION OF GEON 590X4, DOCUMENT IN CHEN GROUP ENVIRON AFFAIRS DEPT FILES* DESCRIPTORS ******* TSCA INVENTORY JCHLOROETHENE AND N-CHYOROXYMETHYU-2-PROPENAmOEJ CAS.N0.65045-74-IIGE0N 590X4 REVIEW YEAR 2059 j ITEM 366 % ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR 265 GEN ; ,;r JOURNAL ,, OCCUPATIONAL EXPOSURES TO RADXOFREQJJENCY RADIATION U8-31tMHZ* .fROMRF DIELECTRIC M|aT 8EAURS cox c,none5Murrat he,none;folet epjhone; v ***4*.** (s-- ^ AIHA.VDL 43 NO.3 PP.149-153* 1982, MARCH r RAOIOFREQUENCY IRF) RADIATION IS THAT PORTION OF THE NONIONIZING ELECTROMAGNETIC SPECTRUM FROM APPPOXIMATLEY 0.01-300,000 MEGAHERTZ (IttZ). WITHIN THE RF SPECTRUM, RESEARCHERS HAVE REPORTED BIOLOGIC EFFECTS IN EXPOSED AMMALS ANO HUMANS. OF PARTICULAR CONCERN ARE EFFECTS ASSOCIATED HITH EXPOSURE LEVELS BELOS 10 MII^IWATTS PER SQUARE CENTIMETER (tftt/CM*), THE CURRENT OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION (OSHA) STANDARD. THESE REPORTED EFFECTS IN ANIMALS INCLUDE MICROSCOPIC OCULAR CHANGES? ALTERATIONS IN NEUROENDOCRINE FUNCTION ANO IN THE CENTRAL NERVOUS SYSTEM, BEHAVIORAL CHANGES, CHANGES IN THE IMMUNOLOGIC SYSTEM* AH) EMBRYOTOXIC AND REPRODUCTIVE EFFECTS. SINCE THE LITERATURE INDICATES THAT DEVIATIONS IN NORMAL BIOLOGIC VARIABLES CAN OCCUR AFTER EXPOSURE TO RF El (GY BELOW 10 MW/CM, THE NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH (NIOSH) INIT1ATJ AN EPIDEMIOLOGIC STUDY TO DETERMINE EFFECTS OF RF RADIATION ON REPRODUCTIVE FUNCTK IN AN EXPOSED WORKER POPULATION. pREl Y INVESTIGATIONS INDICATED THAT A POTENTIALLY EXPOSED^ (Eft POPULATION OF 30,000^50,000 MAl DIELECTRIC HEAT SEAL! THAT OPERATE IN THE 3-100 MiZ Ri HITHIN INDUSTRIES UTILIZING RF RAOIOFREQUENCY RAOI/ ON}OCCUPATIONAL EXPOSURE DIELECTRIC HEAT SEALERS!THERMATRONlCOSMO|tFARA; 1989 r`/4tu,' (*' rS&T: RPTHTnUT FOR GARY JONES 'V PRINTOUT FOR BART JOCS ORDER NUMBER 660827-135259-HIZ -OOl-OOL PA6E 127 SET * WITH SOS OFMfl) ITEM 369 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFXLIATION ORIGIN DATE ABSTRACT DESCRIPTORS ****** HELD TERMS REVIEW YEAR 260 PUBLICATION EPIDEMIOLOGICAL AND Cl SOUTAR CAiNONEIBAULD NONE PB84-11040tt 1981, JULY THE PRESENT STUDIES JURE DESIGNED TO EXAMINE THE PREVALENCE %F RESPIRATORY ABNORMALITY IN ALL OTHER MEMBERS OF THETCURRENT WORKFORCE WHO HAD WORKED AT ANY TIME IN THE DUSTIER PLANTS IN THE FACTORY AND WHO HAD^NOT BEEN XNCLUOEO IN THE FIRST SURVEY,"TO IDENTIFY ANY INDIVIDUALS WITH CLINICALLY IMPORTANT CHEST ILLNESS, AND TO EXAMINE IN THIS POPULATION AND IN THE ORIGINAL STUDY GROUP THE RELATIONSHIP BETWEEN DUST EXPOSURE AND RADIOLOGICAL?APPEARANCES BASED ON NEW READINGS OF THE CHEST RAOIOGRAPHS. RESPIRATORY EFFECTSJPVCiPVC DUST;MORBIDITYjEPIDEMIOLOGY; \a .< RAOIOLOGY; CHEST RADIOGRAPHS; NTIS; ,W 1989 ITEM 370 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE ABSTRACT DESCRIPTORS **** HELD TERMS 232 GEN TECHNICAL REPORT CLOSED ROOM STUOIES TO RELATE AWIENT VINYLIDENE CHLORZOf^HONOHEB COHCENTRATIONS TTTRESIDUAL VINYLIDENE CHLORIDE MONOMER COWtWTRATIONS IN UTEX AMfegs* * - ' WEAVER DE'BFG-CHEMICALI V -M ' -H - ^ BFG-CHEMICAL, i 'H '>'.* V 1984, JANUARY 31 ' GEON 66041 UTEX CONTAII BOO MG/KG VINYLIDENE CHLORIDE (RESIDUAL MONOMER) HAS PROCESSED IN A CLOSEO AND UWVENTILATED#OOM. AIR SAMPLES SHOMEO AMBIENT LEVELS bF VINYLIDENE CHLORIDE DID NOT EXCEED 5PPM (1983 ACGlTTLV) AT A 952 CONFIDENCE LEVEL. SINCE RESIDUAL VINYLIDENE CHLORIDE LEVELS IN GEON`3 650X27,660X13,AND HYCAR 2600X335 UTEXES ARE NELL BELOW 600 H6/K6 PROCESSING OF THESE HYCAR 2600X335 UTEgES ARE WELL BELOW 800 MO/KG,PROCESSINS'0F/YHESE+PR0DUCT3 SHOULD-BE BELOW THE PUBLISHED TLV. VINYLIOENE CHLOR GEON 66041 UTE TEX?GEON 660X13 UTEX) HYCAH6609X335 UTEX) y.&Y- :*"/ ITEM 371 ACCESSION NUMBER FILE LOCATION .DOCUMENT TYPE 'TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN DATE ABSTRACT 205 GEN JOURNAL VINYL CHLORIDE D] WALKER AE.NONE; NONEVOL 105 SUF * * BRIEF REVIEW MEDICAL AND EPIDEMIOLOGIC FINDINGS REUTEd'ftTViHYL CHLORIDE IN PVfc'MANUFACTURE. COINAGE OF TERMirVINYL CHLORIDE DISORDERi -. &*!*.* (* v;J. j- x > so PPTMTnilT FOR RARY JONFS r>n f;on ,->o PRINTOUT TOR GARY ORDER NUMBER W0et7-135259-HIZ > rOpi-O PAGE 12S SET 4 NITH 3S5 OP SM JYW DESCRIPTORS wwrtrtR VCMtACROOSTEOLYSXS!AW^bSARtRXtttTHRGMBOCYTOlteN HELD TERNS ROYAL HOSPITAL ENGLAM) {BRITISH J OF DERMATOLOGY SYNDROME{SC LERODERhA1HEPATOMEGALYI ITEM 372 ACCESSION NUMBER 195 FILE LOCATION GEN DOCUMENT TYPE TECHNICAL TITLE OR SUBJECT MARK STABILIZERS AUTHOR/AF fX LIATION nonenone; ORIGIN ARGUS CHEMICAL COR| DATE 1961, JUNE ABSTRACT DESCRIBES EPOXY ftASTICIZERS,LIQUID STABILIZERSSOLID STABILIZERS: FACTORS AFFECTING THE STABILITY OF VIN*t COMPOUNDS{STABILIZER RECOMMENDATIONS FOR SPECIFIC APPLICATIONS. DESCRIPTORS ******* MARK A,MARK XlrvCJPLASTICIZERS HELD TERMS MARK MJMARK LLJMARK KCB5MARK BBJMARK RFDSMARK PL(MARK GSfHARK XVj MARK CSMARK XXJMAJK DMYIMARK XI;MARK TT;MS} MARK 99JMARK E} MARK HHiHARK 33}MARK 34tM<RK 35} ITEM 373 ACCESSION NUMBER U6 ' '5 > --x *'mtt * ` FILE LOCATION GEN OOCUMENT TYPE JOURNAL TITLE OR SUBJECT AUTHOR/AFFILIATION STUDY ON INJURIOUS PROPERITE3 OF COMBUSTION PROOUCTS OF BUIIOIHB MATERIALS AT INITIAL STAGE OP FIRE KISHITANI K.UNIV OF TOKYO} /, ORIGIN J OF FACULTY OF ENGINEERING,VOL NO.l PP.1-35} DATE 1971, :ff ABSTRACT THE STUDY HAS MADE WITH THE PURPOSE OF CLARIFYING THROUGH EXPERIMENTS HEHARMFUL NATURE OF A BUILDING MATERIAL AT THE TXME&F ITS COMBUSTION AND IS FEATURED BY COMPREHENSIVE BIOLOGICAL EXPERIMENTS. SUCH TYPES OF EXPERIMENTS HAVE OFTEN BEEN CARRIED OUT IN THE FIELD OF BUILOING, BUT ALMOST ALL OF THESE HAVE BEEN CONFINEO TO THE REUTIVE HARM DEPENDENT CM SURVIVAL OR DEATH OF THE ANIMALS USED IN THE EXPERIMENTS. THIS STUDY DELVES INTO THE CAUSES OF DEATHS OF THE TEST ANIMALS FROM WHICH IT IS ATTEMPTED TO ASCERTAIN THE CHIEF REASONS FOR THE HARMFUL NATURES OF BUILOING MATERIALS.THIS PAPER REPORTS ON EXPERIMENTS USING MICE AND IT MAY NOT BE POSSIBLE TO RELATE THIS DIRECTLY TO HUMAN BEINGS, BUT AT THE LEAST IT MAY BE SAID THE EFFECTS OF GAS 6ENERATE0 AT TIME OF COMBUSTION IS AN IMPORTANT MATTER FOR CONSIDERATION MORE THAN SIHPLE SMOKE. DESCRIPTORS ******* COMBUSTION PROOUCTSlCARBON MONOXIDEJMICEJPOISONINGJFIRE; SMOKE}IRRITATION OF SKIN,HEADACHES} HELO TERMS CONVULSIONS{RESPIRATORY EFFECTS}STOMACH}INTESTINES}KIDNEYS}HOOD(PVC}POLYSTYRENE{RESINS, BUllDING MATERIALqfPAROXYSMAL TACHYCARDIA5WOOOHOOL-CEMENT BOARD} PLYWOOD}POLYURETHANE} ITEM 374 J .m 'accession NUMBER 112 FILE LOCATION GEN DOCUMENT TYPE TITLE OR SUBJECT TECHNICAL REPORT 1SOLATEO THERMAL OFF-GASES FROM. BROUN GEON COMPOUND STABlUZED NITH DIBUTYITIN BMMBUTYL MALEATE AUTHOP/AFFXLIATION NIKORA JABFG-AVON LAKE} . H>TMiniir rf'R P*PY IONFS CGb*3120 PRINTOUT FOR GARY JC ORDER NUMBER 06OdE7-135E39-HIZ -OOl-OOl PAGE 1E9 SET 4 WITH 3B5 OF 3B5XTEM3 - ORIGIN DATE ABSTRACT DESCRIPTORS HELD TERMS REVIEW YEAR BFG-AVON UKIWL.._ 1903, JULY 19 THE MAJOR OFF-GAS JDEHTtflED^WJRING THE TRAPPING EXPER RELATIVE CONCENTRAHON 0f^NC2AU)ENYREBUTANAL COMPOUND VS.''THE #IGllUmA^]tlATORti EXP^IMEN. MAS OETECTED. BUWAL'XS^I^rRONG XRRXTAMfSMiff OPERATOR ILLNES^raBLEM MENTIONED. ^ 5 ^ OIBUTYL MALEATE!BUTYL MALEATEJMAIEICANHYDRIDE N-BUTANOLJBUTANALi V ~k 1990 ` ITEM 375 ACCESSION NUMBER HI ' : *-? FILE LOCATION GEN DOCUMENT TYPE TECHNICAL REPORT TITLE OR SUBJECT MALEIC ANHYDRIDE AIR MONITORING FOR BROW GEON HD4XM COMPOUW? AUTHOR/AFFILIATION ERNES DA>BFG-AVON LAKE! i^ ORIGIN BFG-AVON LAKE, / DATE 1983, JULY 8 f ABSTRACT A BROWN GEON COMPOUND IS BEING PRODUCED FOR A WINDOW FRAME PROFILE, BECAUSE OF THE POSSIBILITY OF MALEIC ANHYDRIDE FORMATION FROM THE TIN MALEATE STABILIZER, AIR SAMPLES WERE COLLECTED ON THREE SEPARATE COMPOLMJING RUNS. ONLY ONE SAMPLE SHOWED ANY DETECTABLE MALEIC AIWYDRIDE. THE LEVEL FOUND, .07M6/M3/WAS HELL BELOW THE TLV OF l.QMG/HS* SO THERE STILL DOES NOT APPEAR TO BE A PROBLEM WITH MALEICANHYDRIDE EVOLUTION. * DESCRIPTORS **** MALEIC ANHYDRIDESflffTYL MALEATE{GEON? 4 Mfr '}# '&| ** ITEM 376 ACCESSION NUMBER 99 FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT GEN TECHNICAL REPORT GEON 30 PHENOL EXTRACTABLES, & w jfp ' f?v.v. AUTHOR/AFFILIATION PAZUR AS,BFG-AVON LAKES % l- ORIGIN BFG-AVON LAKE, TO BFG-AVQtf LAKES DATE 1983, AUGUST 24 / ABSTRACT HOFFMAN PRODUCES A FLEXIBLE PIPE COMPOUND FROM LONG BEACH GEON 30. THE PIPE SHOWED PHENOL EXTRACTABLES AT LEVELS TWICE THE NSF LIMIT, CONFIRMING THE NSF RESULTS. THE USE OF BIS-PHENOL A SHORTSTOPPED RESIN RESULTS IN COMPOUND HITH PHENOL EXTRACTABLES SIGNIFICANTLY ABOVE THE NSF LIMITS. EVEN HITH THEiUSE OF NON-SHORTSTOPPEO RESIN, OUR GEON 06155 APPARENTLY CONTAINS SOURCES OF PHENOL WHICH PUT IT AT THE LIMIT OF NSF ACCEPTABILITY. DESCRIPTORS ******* PVC RESINIGEON 30;RRENOLS;FDA}NSFJEXTRACTION TESTS .ITEM 377 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 90 GEN CORRESPONDENCE GEON 30 PHENOL EXTRACTABLES BACHTEL HC18FG-AKR0N; r *u<gasi30 'A Jr M t tr*tt rnp rapy hnfs PRINTOUT FOR GARY ORDER NUMBER 660S27-135259-HXZ *OQl~Mt PAGE 130 BET 0 WITH 305 OF MSITtMS ORIGIN DATE ABSTRACT DESCRIPTORS ITEM 376 BFG-AKRON, TO wfo&wfc 1963 SEPTEMBER 1 SUtflARY OF THEIR AND FDA USES AS ******* GEON 305PHENO SATZOtf REGARQING| EO IN REPORT DA-tEBj RESlNStNSFiFOAJ? ' fv _ ACCESSION NUMBER 64 FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION GEN JOURNAL ANGIOSARCOMA OF THE SUPERIOR VENA CAVA ABRATT RPPROVINCIAL HOSPITAL SOUTH AFRICA] CLLIAMS H'NQNEIRAFF H'NONEI DOOD NF.NONEIUYS CJ,UNIV ORIGIN OF CAPE town; CANCER'VOL 52 NO 4 PP.740-743J OATE ABSTRACT 1963' AUGUST 15 / THE FIRST REPORTED CASE OF AN ANGIOSARCOMA APPARENTLY ARISING FROM THE SUPERIOR VENA CAVA IS PRESENTED. THE PATIENT' A 20-YEAR-OLD JjgKITE MAN* HAS TREAtED BY SURGICAL EXCISION AM) RECONSTRUCTION WITH DACRON GRAFTS FROtt THE LEFT AND RI6HT BRACHIOCEPHALIC VEINS TO THE RIGHT ATRIUM. THIS HAS FOLLOMEO BY A CQURSWOF MEDIASTINAL IRRADIATION. THE PATIENT REMAINED CLINICALLY DISEASE-FREE AT 24 MONTHS POST-TREATMENT. THE PATIENT HAOOCCA9X0NAL OCCUPATIONAL EXPOSURE TO - POLYVINYL CHLORIOE. . r' M > DESCRIPTORS ******* CANCER5ANGIOSARCOMAIVENA CAVASP^ OCCUPATIONAL EXPOSURE!'**-!'* w*V. ITEM 379 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE ABSTRACT 1; - >* "Al- V--.'** 61 gen ' . fi / .r.F. -ir , >> ' JOURNAL THE EFFECT OF AGE AND EXPOSURE DURATION ON CANCER fiCUCTXOtt'fCNOHN CARCINOGEN IN RATS* MICE, AND HAMSTERS . /- DREW RT,NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCESfBO&bMAN GA SAHEJHASEHANJK.SAHEJHC CONNELL EE,SAMEJBUSEY MM'SAMEJMOORE JA SAME! TOXZCOLOGY AND APPLIED PHARMACOLOGY, VOL 66 NO 1 PP.120-130} 1983, MARCH 30 * AT THE END OF THE STUDY THE INCIDENCE OF VC-INDUCED NEOPLASMS HAS COMPAREO IN EACH OF THE 6R0UPS TO ASSESS THE EFFECTS OF DURATION OF; EXPOSURE AND AGE AT THE START OF EXPOSURE ON CARCINOGENICITY OF VC. IN RATS, WITH EARLY INITIAL EXPOSURE, HEMANGIOSARCOHAS, HEPATOCELLULAR CARCINOMAS, AND MAMMARY GLAND CARCINOMAS OCCURREO WITH INCREASING INCIDENCE WITH LONGER EXPOSURE DURATION. RATS HELD FOR 6 MONTHS BEFORE EXPOSURE'DEVELOPED VC-RELATED NEOPLASMS* WHILE RATS HELD 12 MONTHS BEFORE THE START OF EXPOSURE FAILED TO SHOW A SIGNIFICANTLY INCREASED INCIDENCE OF THESE NEOPLASMS. IN HAMSTERS HEMANGIOSARCOHAS, MAMMARY GLAND CARCINDMAS'6A3TRIC ADENOCARCINOMAS, AND SKIN CARCINOMAS RESULTED FROM ft EXPOSURE. THE HIGHEST INCIDENCE OF MALIGNANT NEOPLASMS OCCURRED IN HAMSTERS EXPOSED FOR THE FAST 12 MONTHS, WHEREAS. EXPOSURE BEGUN AFTER 12 MONTHS OF AGE DID NOT CAUSE NEOPLASMS. IN BOTH AINS OF MICE, VC EXPOSURE OURING THE FIRST 6 MONTHS OF THE EXPERIMENT INDUCED A HIGH ENCE OF HEMANGIOSARCOHAS ANOMAHhARY GLAND CARCINOMAS. SWISS MICE ALSO DEVELOPED LUNG CARCXl AFTER ONLY 6 MONTHS OF EXPOSURE.lN ALL THREE RODENT-SPECIES AN INITIAL 12 MONTH EXPOSURE VC HAS ADEQUATE TO DETECT ItS tfr&NOGENIC POTENTIAL, BUT THE SHORTENED SURVIVAL OF VC EO MICE AND HAMSTERS PRECLUDE^ (k MEANINGFUL COMPARlSOti^gTH LOGGER PERIODS OF EXPOSURE. EX WERE MOST EFFECTIVE NHEN tSME^ftfiJURLT^lN LIFE. ..v 520898131 *r'#: 3FG 52820 rPTHrmrr for gary jonfs ,-i1 *>.< I PRINTOUT FOR GARY JONES ORDER NUMBER 860887-135259-MIZ -001-00* PAGE 131 SET 4 M1TH 385 OF 385 JtOtS '' } .'v DESCRIPTORS ABE I VINYL CHLORIDEI ADENOCARCINOMA; 'd'i* ITEM 380 ACCESSION HUMBER r- FILE LOCATION 59 6EN DOCUMENT TYPE JOURNAL TITLE OR SUBJECT EVALUATION OF THE ASSOCIATIC AUTHOR/AFFILIATION THERIAULT G, LAVAL UNIVtll ORIGIN TERATOLOGY,VOL 87 PP.359-37J OATE 1983, CIRCA ABSTRACT BIRTH OEFECTS INCIDENCE FQR INFANTS BORN TO RESIDENTS OF SHANINX6AN,CANADA IN 1966-1979 HERE SIGNIFICANTLY HIGHER THAN THREE COMPARISON COMMUNITIES. SINCE THERE HAS BEEN A VINYL CHLORIDE POLYMERIZATION PLANT IN [S TOWN SINCE 1943 FROM WHICH TEN CASES OF ANGIOSARCOMA OF THE LIVER HAVE BEEN IDENTIFIED, THI STUDY EXPLORES THE POSSIBLE ASSOCIATION BETWEEN EXPOSURE TO VINYL CHLORIDE MONOMER tVCM) II ^AMBIENT AIR AND THE OCCURRENCE OF BIRTH OEFECTS IN THE COIflUNITY. DESCRIPTORS ******* birth defects;vch;angio: icoma;lxver;polymerization; hypospadias}Cataract;D(aws sywrome; EPILEPSY{MENTAL DISORDER pstcho3is;rubella;pregnancyjcns;shAminIgan; ITEM 361 ACCESSION NUMBER 57 -v '/! : ' FILE LOCATION GEN ,J * ' ' ' DOCUMENT TYPE PUBLICATION ^ TITLE OR SUBJECT CONTROL OF EXPOSURE TO POLYVINYL CHLORIDE DUST ,,/ AUTHOR/AFFILIATION NONE,NONE} M V- ORIGIN HEALTH AND SAFETY EXECUTIVE dttlOANCE NOT EH 31} ,, DATE 1982, MAY M ` ABSTRACT THE HEALTH AND SAFETY COMMISSION'S ADVISORY COMMITTEE ON TOXIC SUBSTANCES HAS RECOMMENDED THAT, IN LINE WITH THE COMMISSIONS GENERAL POLICY: EXPOSURE TO PVC DUST SHOULD BE KEPT AS LOW AS IS REASONABLY PRACTICABLE*, Ife&NY CASE EXPOSURE SHOULD NOT EXCEED 10 MG/M3 FOR TOTAL PVC DUST IN AIR AND 5 MG/M3 FOR RESPIRABljgPVC OUST IN AIR. THE EFFECTS OF EXPOSURE TO PVC DUST ARE REFERREO TO IN PARAGRAPH 9 AND AOVICffStS GIVEN ON ASSESSMENT AND CONTROL IN PARAGRAPHS 10 TO 13. METHODS OF SAMPLING AND MEASUREMENIlXRE DESCRIBED IN PARAGRAPHS 14,15 AND THE APPEtOIX. DESCRIPTORS ******* pvc dust;axr; STABIL1Z|JPLASTICIZERS;ANTI0XIDANTS1VINYL CHLORIDE MONOMER}AIR SAMPLING}THA; RESPIRABLE DUSTiTOTAL ST;OUST SAMPLING} " ITEM 382 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE .TITLE OR SUBJECT AUTHOR/AFFILIATION ORIGIN OATE ABSTRACT 37 6EN PAPER THE STABILIZATION OF FOOO GRADE POLYVINYL CHLORIDE COMPOUNDS WTO FDA SANCTIONED Dt-N-OCTYLTIN STABILIZERS LARKIN NA.M A T CHEMICAL INC}SHELDON AH,SAME}SIMMONS XL,SAME* SPE, 26TH ANNUAL TECHNICAL CqpFERENCE.N.Y. 1968, MAY 6-10 ON JANUARY 80, 1968, AND MENT TO SECTION 1U (NON SEC,178.8650) OF THE FOOO PRODUCTS OF FDA NAS ISSUED, ALLOWING THE OF TWO DI-N-OCTYLTIN .COMRXJNOS AS STABILIZERS FOR POLYVINYL CHLORIOE mu' * 'dim- i'*init<iMT FPP rpy IOHF4 SJHUl AOVJ aUJ Ihulitiuii & > gItIgso :* 'VP. V nK ,hi. 039ianza iNvaruoxmtiZNaaosxiAmauis^d^viH N jsfcazxixsvis JaoxaoiHoxa NiiiAirwxaSNotiisodwraaa JHHHHHHt SdOldlttOSaO 7f i il. `ividaivM aiunoA v sv dawnod am MoadipiVNiwna si u jo KW.ONV.riLLViQA si oaisa `xaidwoo nu in31vavx3h v jo Nonvwdoj aHitHonoam sanooo niNadvdav hsihn 'auzdcnio caiva?aii hoikm dawnod ski jo Noiivavaaia awos jo nnsaa v sv sniiiih fiNianoionooHdaixinoA v sv osaioas osiv si ocllso `ONnoduoo 3hi ni aasn aaznisvis ivNiaavo am. hz aoxabiHOKMinunaia jo iNnowv aAissaoxa nv 01 ana svm xaah isn d39*iv iv SHmiu SNiana ctwnodMoa dt&L-iH mao jjo sniwoo sdoavA SNiiviitaix am. lvm stivaddv 11 lovdisav * vV % V vr., OS 3Nnr *9961 0 9 9 01 1 0 3 9 9N MXV- J * V IW Ha- J 1 3 3 3 9 1 3i V IH H - Ja*fl M GIdO 31 039dH *IH N UOHJ siviaaiYH aizivnoA 31V0 NZ9IdO NOIlVIllJdV/dOHinV loarans do aim aaoo adAi iNaunooa N39 N0I1V301 31IJ 92 daSUON N01SS330V 99 W31Ii isoNYis lVNaaaviaxomKiidaAiifsrsuKiisvainHYdisdNmuaNaix is3H30xn3i!6aiA30uHiAU3!SNV9ao nvaotsiva (ainov (aoiaoiHOio Niruinaio isionaoad NoiiisodMQ33aidu3i-iH Noa9!os<nii-3inoua3Hi *** sdoididosaa `39VWVG 1VN39 1V30J JO aoNaOXONX 1NV3IJZN9IS V 030n0NI S13A31 9U OOT ONV 0 3Hi HJL09 109 HVWdONQV 3H3H S9NIQNIJ 1V3IW3H3 00019 dON 1V0I90101VW3H am M3KII3N -QaivAna siHsiaM nvs&q onv `aassaadaa 3d3M axviNi aooj onv HiM0d9 9X/9W OOZ IV ins 31V103Hd31NZ 3d3H 8133333 9X/9M 0 IV `031013143 VId31ZdO 3m 30 ANV A9 81Vd 10dlN03 30 3S0H1 UOdJ d3J3I0 ION OIQ 36N0d83d 3m *13A31 SU 01 3m IV `1VH131 SVM GNOOdUOD 3m S13A31 1S3H9IH OKI am iv *tivd am aoj ox* 01 Aiaivuixodddv 30 osoi nv ovh hoihn aiduvs daiidva nv 01 NOIlONXlSXOVdlNQO NI) 1H913H A009 9X/N9 WO 30 0801 IVdO aiTOV NV OVH II *t3JsS1 `ON 3003 3HI as aai3iiN3Gi is-i umau 30 aiduvs v min sivd ni oaiananoa aaan avo sad ih913n aoos sm/su ooo`i ONV `00 *001 *0 *01 30 813A31 39V80Q 9NIAQ1dH3 S1S31 9NI033d AVQ-06 *dd03 1 V U d03 3N0a AOHIS lovmsov 13 d39U3A0N <0961 aiva ,,v - *3NI son H3dV3S3H 90d0 ONV QOOJ NI9Id0 .. - "u4 !3N0N `3N0N NOIlVIlIJJV/dOHinV {? j * rai-svis-i lAiuau hum saxarus SNiaaad ainovons loarsns do ami .'* ,*A ill AQniS JUI3IX01 3dAl lNiWnOOQ I* *** ,9* N39 N0I1V0O1 3113 93 d3SM0N N0ISS330V ) xf .. . ^ US31 N0I19VH1X3133NVld330V VOJ v)3Adt3NVXaHUlVN0Id0dd01dV3d3M Ninunflio iaiviaovoidvodamiioposi-szo NiiiAinsia saazidvodauiAdnvi-sis Niiiungia )3ivaivu NiiiAimiaiaivdnvizo NiiiAihsxa J3ivi3ovoidvoaaimi9oosr-sig niuaiooio taivaivu nihaiooio ihhhhmh `Noiivdoioosio onv Noiivavdsaa ivudam isnzvsv datuiod am oNiio3iodd jo nozionoj idvuidd am udojdad SNOiivoziddv 3QVd9 oooj wj saaziiiovis *oi9i iv oaniu nshm nsa3 doioosia ainon no NV39 VAOS 03ZiaiXOd3 NV SV H308 AX0d3 NV UNO miM Q32I1JSV16 OAd 0I9IB V *31dUVX3 dOd `3N01V aasmNaHN 3AI103JJ3 10N " `snuonwiq rividaivw onznz aamoNi imiLasam UsnivA o 90 3HJU*KdW03 OlNVddQ ONVJOndOHdSOHd *3NI2 *Uni31V3 `avalpN^ 'lNOMZlNV *HniU0V3 4KUdV8 NO oasvs SONnOdUOO diak^i ssnvaas sNoziV3Zlddraovd9 oooj ttoj aadaoxsNoo as ittwvo saazruevis rim 30HNVU * (t9 31Z10Ud3Hl) 1aiV133V01dV3d3W1AlD0OSISig MZ11U00Z0 ONV (10 31 aiVilVIf NIUAIOOIO l3d3M VOJ 3H1 AS 031NVB9 SVM N0I1DNVS oni sivoiuatq SVI| NOXlXiad V HOIHN d03 SONpOdNOO OHi am 'SaiOIidV 9 W31I sdoididosao SH3U't JO SS miH V 138 31 39Vd 100-100- ' ZIH-6fiaSW38098 d39UDN d30d0 SWOC AdVfl MOd inoiNidd BFG52822 PRINTOUT FOR GARY ORDER NUMBER S608E7-135259-HIZ -OOl-OOl PAGE 133 SET 4 WITH 3B5 OF 3W SULFIDE JCAROIW^tUAfr ^ ITEM 365 ACCESSION NUMBER FILE LOCATION DOCUMENT TYPE TITLE OR SUBJECT AUTHOR/AFFILIATION 6EN BOOK PARENTERAL TOXICITY OF A SSIZES OF COMMERCIALLY^! USED IN PVC FORMULATIONS - r } a GUESS N L. UNIV OF TEXAS) O 'LEARY R K* SAME)CALLEY 0, ' ORIGIN UNKNOWN a'V,' DATE ABSTRACT 1966 * CIRCA . ?' SALIENT FEATURES OF THIS RESEARCH SEEMS TOJNfalCATE THAT THE PXOCTYL AND DIBUTYL TIN STABILIZERS USED IN THIS STUDY EXHIBXt A HIGH DEGREE jrTDXICXTY WHEN ADMINISTERED BY THE PARENTERAL ROUTE. THIS HAS EVIDENCED BY THE LON HG/K6. LOW VALUES* THE NECROSIS WHICH RESULTS FROM DIRECT MUSCLE INJECTION* AND BY THE INTERDERMAL IRRITATION TEST. IN ALL THESE.CASES THERE HAS EVIDENCE OF EXTREME CORROSIVENESS. EVEN THOUGH THESE EXPERIMENTS DID NpT DEMONSTRATE EXTRACTIBILITY OR LACK OF OF EXTRACTIBILITY OF ORGANOTIN FROM A RIGID PVC FORMULATION* THERE HAS SOME INDICATION OF LEACHING AS INDICATED BY NUSCLfcjOAMAGE AROUND THE IMPLANT*,BUT THIS HAS NOT CORROBORATED IN THE TISSUE CULTURE TEST WITH PVC EMULATIONS AND EVIDENCE OP TOXICITY IS BEING CONDUCTED AT THE PRESENT TIME. `M -7 DESCRIPTORS **** MICE! RABBITS*TOXICITY;IP;MSCLESKIN IRRITATION{DERMAL; EYE IRRITATIONJORALSOIBUTYLTIN DIISOOCTYL MALEATEJDIBUTYLTIN DIISOOCTYLTHIOGLYCOUTE; DIBUTYLTIN DIUURATEiOlBUTYLTIN OUAURYL MERCAPTIDE; DIOCTYLTIN BETA MERCAPTOPROPIONATE; MINERAL OXLSJHI SE0N103 EPJ THIS LIST OF PRINTS IS BASEO ON* .ITEMS. LINE SET l: 156 SET 2: 225 SET 3! 36 SET 4: 385 REQUEST DE-VCM DE-PVC OE=GEON DE=1VCM OR PVC OR GEON) X .^ i . ; N PLEASE MAIL THIS PRINTOUT TO: . r V* `'itct- 4r ' -- 'I { % .If, 1 fr`` C.DILLON D/0020 24B ORDER NUMBER 660927-135259-HIZ -001 (1 PRINTS). ;:* ^ %" . i.W, nnnnnnnnn TTTTTTTTi DDDDODDDD DDDDODDDD DDODOODDDD DDDODDD r~', DD DO fe,PD DD ^Trv,;0D DD m do r"* DD ?v DD DD , DD OD DD OD DD DDDODODDDD DODDOOOOOD DOOODDDDO ODDOODDOD vu. rt CN oc CN TT1111 II1 II 1 TTTTTTTTTTTT TT TT TT TT TT TT TT TT TT TT 777777777777 77777777777 77 77 77 77 77 77 77 77 77 77 77 3333333333 333333333333 33 33 33 33 3333 3333 33 33 33 33 333333333333 . 3333333333 11 111 mi n n li li n li n iiiiiiiin iiiiiiiiu '; ' * P' 1 ' `y ' ' l: < NN NN NNN NN NNHN NN NN HN NN NN NN NN NN NN NN NN NN NN NN NN NN NN NNNN NN NNN W; NN r... NN N in P m KN END TSU 731 DDILLON 1 *N END TSU 731 DDILLON 1 *N END TSU 731 DDILLON 1 001 001 AKRNMV51 DDILLON/TSO SYSOUT 001 001 AKRNMVS1 DOILLON/TSO SYSOUT 001 001 AKRNHVS1 DDILLON/TSO SYSOUT ROOM 24B ' - 1.55.36 PH 27 AUG 66 PRINTER2 IPOl END N* ROOM 246; 1.55.36 PM 27 AUG 66 PRINTER2 1P01 END N* ROOM 24B- 1.55.36 PM 27 AUG 66 PRINTER2 IPOl END N* rAF:!y* *