Document 10k406o7kpmj1qnZowpjajY2m

FOR DU FONT USE ONLY AR226-2755 Copies co:' E. I. du Pone d* Neoours and C. ly Haskell Laboratory for Toxicology and Ino, .crial Medicine Elkton Rjoad, Newark, Delaware 19711 UASKELL LABORATORY REPORT NO. 662-80 Material Teeted Occanoic Acid, pencadecafluoro-, aoaoniuB sale* Haskell No. 12.037---- r Other Codes Scudy Iniciaced/Coapleted 8/12/80 - 9/3/80 Material Submitted bv CR&D Dept. Haakell Laboratory SKIN ABSORPTION LD50 - FEMALE RATS raf Procedure; Two group* of ChR-CD^female rats, 5 per group, were clipped free of hair over che back and trunk area. The cesc material, aa a 50/50 aqueous suspension was applied to the bafk of each rat under a aquare of aluminum foil and held to place with 3" ElastoplastO. After 24 hours exposure the racs were unwrapped, sponged off with a aild detergent, rinsed, dried and returned co cages for 14 day observation or uncil| death* Surviving rats were sacrificed. Resuica: No. of Animals 5 Dose <;"g/^) 7,500 Active Ingtedienc Average Dose (g) 1.38 [ Average Weight (g) Initial/Final 183 226 Mortality 1/5 5 5,000 0.96 191 235 0/5 Clinical Sifl;na: 7,500 mg/kg Mild skin irritation, stained face, wet and stained perineal area and initial weight loss. Death occurred 3 days after ereatment. 5,000 mg/kg Mild skin irritation and inceraiceenc weight loss. Summary: Occanoic Acid, pencadecafluoro-, aaaoniua salt: is slighi.ly coxic in female raca by skin absorption, its LD50 is greater than 7,500 mg/kg, che maximum feasible dose. All racs. dosed at 7,500 and 3,000 mg/kg had mild skin irricacion and inicial weight loss. - 1 Company Sanitized. Does not contain TSCA CB! John E. Hwnry / Technician Approvd by; i Qfc^JU-y. to___ Grxld L. Kanudy Chltf, ACUCB Invcigaeiooa Saccioa JEH:jrg Scudy Diraccor: 0. L. bahill .Date Isautsd: SpfbC_22, L980 22- ...n^roico^smTSCACBI ^W^^60-"