Document 10VeOD8Vxp9apG77YpkJD05yE

) It-' ?au as. 1959 Mr. I. Wilbur Jpclihw iklrlitnuy, Znduatrial Syglano Vaatlncfiouao naatrla Corporation But fittaburgh, HoM7lnAli Batr lUbffi Tfeosk /cm far your lHUr of Oatobar 21 Inquiring about tba toft um of triahlarodlpbanyl and a alrtuxt of 405 trlahlorotrin aod 605 frmH-i--llr^^rrl M aartart triahlorodipbawl aaf^Aroolar 1242V tba aaablna. tlan of hOTUhlorodlpnacyl andNWd IrloMnrtrtariiflTt la known 41pbooyr<xB>>>BSXaafloblnotlB la our * Sw phytlaol and tbaal wl jroptrtiH of tba Altaian bodtlflood an don on lb* tablo pacta 4 and 5 af tbo analoood Areolar bullatin. fealoood alao la a roprlnt India ting tbo rooulta of nhranla toolalty atudlaa with AroalanfiAACand 1254. ts foliating isBMeti anoraring your guaatlflna aarlally art boaod on InfenaUan aaotalnad In thoao bullotlaa. Z baliara nation** and rapootod akin aontaat with any of tbo Arotlora should bo avoldad for two root ana, Xn tbo flrat float, tba laoa ahlarlnotad products art llfulda and ait axaalma% aolvtnia for olla and fata la tba akin aa oall aa atbar orn&la notarial*, faoondly. It la poaalblt that sroloocad or rapaotad skin rated aould land to ohlaroona. Z boo of only two tooth Omto auob tspcrlansa boa daralopad during tbo long history of praduatian and uao of tbo Aroolera. Za na aaoa, aa iraolor aoa balag uaad aa a baot tranafsr nodlite la a that allooad nptn to taaapo oban tba oadarlal too bootad to by an laduatrtal physio Ion but whlah la hla oardo wtrt ao la* algnlflaont that tea nan wart not aaajrt of than dot would o ganarol praotttlonar notlaa tea, Sila Indlaataa to m, hewrrwr. CBRft 00000 59 TOWOLDMONOOQ1291 Hr. I. VUbtf ) 2~Ootober 23, 1959 that sufficient exposure, idMthsr by Inhalation of vapors or kin ontosti can result in ehloraono *ileh Z think vs aj( aiavas could bo an Indio ation of acre sorlous eysteal# injury If tho exposure vaa alloved to continue. A sooond aaao of slid ohloraons about idiieh vs havo any* * * lenovlodco roaultod frov vorteen dipping their hands la tho liquid drooler aa If it voro alncral oil or vegetable oil. Xn addition, tholr clothing sooner or labor boons lapregnated with tho notorial and thus oxpeouro vaa aagnlfied. You aalesd at diat teaperature local oxhauat ventilation should bo provided. Although tho distillation range for Aroolor 1242 le 345-360C, and 3fl5^SOC. for Aroolor 1200, Z fool that good praotloo dletatos that local axhauot vontllatlon bo provided tdton asor of tho Aroolora are heated above 1507. la open tanka or la any aystono vhoro the aattrial la not In a eoapletoly aneloood I7ita (vapor-proof tanks, kettles, puaps, piping, ste.). This aey bo ultra oeneorvatlvo because as the distil lation rangts and vapor pressure eurvos (pegs 12 of the Arcelor bulletin) Indicate, tho loss of vapore at 1$0F. should not bo otpufleant exeept la any work area toere general ventilation or air changes do aot exist. Your next question related again to possible skin and aystastlo offsets and X believe It Is snsvsrod above. fit connection vlth the 400 trlehlorobensene-60j( Aroelor 1260 eoablnatian, X believe the thoughts expressed above also apply. X uaderstand that the trlehlorobenzsn# tdileh la used la a alxturb of the 1,2,3-, 1,2,4-, and 1,3,5-laomrs idileh will begin to distill at 205C. Again, X believe this Indicates a lev vapor pressure for the solvent at roca taoperatureo. The only reference ve have to trlahlorobenseeo toxicity la con tained la the Public Health Service Publication Vo. 414 entitled "The Balogenatsd Bydrocarbcna Toxicity and Potential Bangers" by ST. V. F. von Osttlngan, U.f. Oovemsest Printing Offlae, 1955 (pages 297-296). Sr. von Oettlngee refers to seas rat dons In 1937 vhleh indicated that tha trlshlorobensaas vaa less toxic than aono or dlahlorobenaane. Zn ay opinion, a reasonable VAC for this aatonal sould bo 100 parts per Billion. The enclosed publication on tho toxicity of Aroolor 1242 and 1234 suggests an M6 for 1242 of 2 allllpaas per cubic aster &iah is tvlee that reeaoBtnded by tho AC02B for a chlorinated di phenyl of imitated chlorine content. Xa tho aaao of 1254, tho publication suggests that tha M0 of 1 allilgna per cubic aster "res amended tentatively for safe Industrial practice br the Aaerleen Conference of Covomaental Industrial Kygleaiste la reasonable. Cn the other hand, reference to Benry fcyth'o Cvaeslflxs Meskerlal Lecture of 1956 la ***"* ha dlaeueeod tho bejLle for the then existing "hygienic standards" Indlsates that SfiRN 000003 60 TOWOLDMONOOQ1292 : Itr. S. lbu *) 3-Citb S3, 1999 _ _ that MIC of 1 as/tu.a. far Aroclar 1248 ib4 0.3 'num. fw Araalar 1254 ftn aora mllitli. fit tha a*. ___ ~af any ahranlo toalalty data on Aroalor 1960. m as mo af 0.3 ma/au.m., tha mm is la tha aaaa of 1254. Z bora bM la am pint mart thaaa material# vara uaad far ufultsn and tnsifenci. fho aart and headline aod tta srovlaleaa of ashauJt raotilatioo Mia aot la aaaordeaaa vita tba thoughts aa^rataad abort. &a oily reported difficulty aoaa mild art irrltatim mao lyt|iatlaa cablaata bna tha itam vara baatad to HO-1290. ralaaaad rapara of trlahlwabanaana and tha Araalar lota tha aortcrtam dm tha tabiarl Zb mr dad, ayah aabiaato dam Id ba ventlittad ta " " " to ba ralaaaad lata tha I hara bam tLd that yaur tmpaoy has had ama 20-25 yaara* axparlaoaa alth tha yraduata dlaauaaad abrrt. Zt ama wccaatad that Or. Am 1. yard, manat*? of traaafecm? aaoifiaturlae anplnaarlao at yaw Aux fUst would ba a aauraa of laformatlM ncmlai asparianaa with toartaen ffO. ilalltrly, Mr. X. X. Jferbw? of yaw Slemlagtan, Indiana riant haa ba aaaoalatad alth tha uaa of Areolar 1944. farhapa you bora al ready dlirwaad rnlMillil tap name with thaaa fanUaman. If ooTz would ba Irtaroatad la laormlas of thaly pratlltal axyarlmaa alth thaaa pridirta Z lam ftraard ta tarias y la niUbrth next waak. Slaaaraly, Aaaiitaat pdraotor 6BRN OOOOCt 61 TOWOLDMONOOQ1293