Document 10E154zeOykg4EmnLMGq6aMpa
HAZLETON
WISCONSIN
POST OFFI CE BOX 7 545 M A D IS O N . W IS C O N S IN 5 3 7 0 7 -7 5 4 5
Sponsor
3M St. Paul, Minnesota
6 50A R H - O H
a C O R N IN G Laboratory Se<v>ces Comoany
FINAL REPORT
Study Title:
13-Week Dietary Toxicity Study with T-5180, Ammonium Periluorooctanoate (CAS No. 3825-26-1) in Male Rats
Data Requirement: Guideline 82-1
Author: Matthew J. Palazzolo, PhD, OABT
Date: May 17, 1993
Performing Laboratory:
Hazleton Wisconsin, Inc. 3301 Kinsman Boulevard
Madison, Wisconsin 53704
Laboratory Project Identification: HWI 6329-100
VOLUME II OF II Page 230 of 657
Phon*
FO EXPRESS-MAIL
OELIVERV
3 30 1 K IN S MA N B OU LE VAR D. M A D I S O N
WISCONSIN
53704
C0139^
CONTENTS
M M E II OFJL
APPENDIX D Individual Individual Individual
Individual
Absolute Organ Weight Oata (g) Organ-to-Body Weight Percentages Organ-to-Braln Weight Ratios
Animal Pathology Data
APPENDIX E Quality Assurance Statement Individual Hormone Analysis Data
APPENDIX F Results of Individual Test Material Residue Analyses
APPENDIX G Method Validation for FC-143 in Feed
Method Validation for T-5180 in jRat Serum
HUI 6329-100
ElSfi
232 233 254 275 295
620 621 622 629 630 644 645 651
231 G0199&
HWI 6329-100
APPENDIX D Individual Absolute Organ Weight Data (g) Individual Organ-to-Body Weight Percentages
Individual Organ-to-Brain Weight Ratios Individual Animal Pathology Data
232 0199^
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ABSOLUTE ORGAN WEIGHT DATA (G)
5 WEEK SACRIFICE
HWI 6329-100 PRINTEO ll-OCT-91
PAGE 1
TABLE INCLUDES: SEX-ALL;GROUP-ALL WEEKS-ALL DEATH-1;SUBSET-ALL
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - L F . TESTIS. TE1 - R T . TESTIS,
SO - ACCESS/SEX ORG
SEX DOSE ANIMAL TERMINAL
GROUP NUMBER BODY WT (9 )
BR
LI
LU
TEO TEI SO
M 1 C67451 M 1 C67457 M 1 C67461 M 1 C67464 M 1 C67467 H 1 C67468 M 1 C67476 M 1 C87477 M 1 C67496 M 1 C674I9 M 1 C67491 M 1 C67492 M 1 C67SOO M 1 C67S02 M 1 C67S03
447.6 375.7 409 0 425.9 420.5 391.0 419.9 420.1 397.0 312.7 311.1 451.9 401.7 409.0 411.6
2.2017 2.0693 2.1204 2.0479 2.1977 2.0211 2.0751 1.9579 2.1131 2.1236 19317 2.1730 2 0014 2.0266 2.0221
17.2636 IS 3067 16.3219 17.2S70 14.6861 14.9006 15.8597 16.9781 16.3091 14 7948 14.4250 23.3031 15 5389 16.5645 15.5999
1.7496 1.4270 1.5015 1.5181 1.6460 1.5845 1.4231 1,6197 1.5415
.8798 1 4507 1 7054 1.5614 1.4831 1.6163
1.7609 1.5370 1.5785 1.6128 1.5841 1.7321 1.8496 1.4154 1.5448 1.8265 1.5006 1.7399 1.6913 1 6655 1.6037
1 7540 1.5080 1 6495 1.6505 1.5651 1 8084 1 8101 1.3969 1 5492 1 7463 1 5182 1 8369 1 6935 1.6469 1 6486
2 6091 2.6754 2.8661 2.3400 2.8690 2.5929 2.8944 2.3930 2 5854 2.6769 2 7280 3 2461 2.4949 2.6034 2.6669
NUMBER IN GROUP : MEAN:
STANDARD DEV:
15 411 1
21.7
15 2 0732 0612
15 16.3409
2.1378
15 1.5138 .2006
15 1.6442 .1250
15 1 8523 1273
15 2.6801 .2257
M 2 C67509 M 2 C67S10 M 2 C67511 M 2 C67514 M 2 C67515 M 2 C67S24
464.1 390.4 399.2 440.2 396.0 376.6
1* CONTINUED ON NEXT PAGE
1.9307 2.0904 1 9736 2 1070 1.9549 2.0306
17.4500 14 2679 14 2649 16.1693 14 9406 15 8071
1 6890 1.6098 1 4599 1.5906 1.4892 1.3185
1 7287 1 6477 1 6229 1.8038 1.5906 1.3102
l 7032 1.6491 1.6199 1 7679 1 5946 1.3303
2.8041 3.1326 2 9169 2 6682 2.2112 2.5370
00199
o
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ABSOLUTE ORGAN WEIGHT DATA (G|
S WEEK SACRIFICE
HWI 6329-100 PRINTED U-OCT-91
PAGE! 2
TABLE INCLUDES: SEXALL;GROUP-ALL.WEEKS-ALL DEATH I.SUBSET ALL
SEX DOSE ANIMAL GROUP NUMBER
M 2 C67S2S M 2 C67S29 M 2 C67S30 M 2 C67537 M 2 C67544 M 2 C67550 M 2 C67555 M 2 C6755 M 2 C67559 NUMBER IN GROUP :
MEAN: STANDARD DEV:
TERMINAL BOOT WT (9 )
434.7 404.5 422.6 359.6 367.7 367.9 422.1 433 7 486.4
15 413.9
34 5
ORGAN
: ABBREVIATION:
BR TEO
- BRAIN. LI - LF. TESTIS.
LIVER. TEI -
LU RT.
LUNG TESTIS.
BR 1.8931 2.1694 2.1161 1.9303 2 0234 1 9897 2.0072 2.1439 2 0513 IS 2 0275
.0842
LI 17.8185 14.7411 14.7178 12.8585 12 9882 14 1445 15.7892 17 5588 18.2277 15 15 4495
1 7139
LU 1.5590 1.4026 1 5587 1.4473 1 4677 1.5451 1 5776 1.6356 1 8181 15 1 5312
.0989
TEO 1.8906 1.7652 1.5795 1.6041 1 5412 1.5024 1.4981 1 6699 1.5783 15 1 6222
.1410
TE1 1 8599 1.7033 1 5950 1.6330 1 6271 1 4836 1.4914 1.6140 1.5797 15 1.6166
1243
SO - ACCESS/SEX ORG
SO 2 7211 2.5456 2 6398 2.0156 2 5267 2 5265 2 7610 2.6345 3.5584 15 2.6799
.3592
M 3 C67S62 M 3 C67565 M 3 C67S66 M 3 C67S66 M 3 C67S69 M 3 C67S74 M 3 C67S76 M 3 C87577 M 3 C67SB0 M 3 C67591 M 3 C87SB2 M 3 C67595
433 8 390 4 421 7 397 0 389 6 396.8 367.9 363 6 391 4 379.3 341.6 414.9
2 0610 1 9778 2.1092 1 9801 2 0820 2.0006 1.8902 2 0559 2.2534 1 9980 2.1789 2.0247
19.3861 16 3602 19.6938 17.9401 16.0008 18 1510 17.4704 16.0948 17.2091 16.6859 14.0101 19.3969
1 4976 1.4864 1 4756 1 3867 1.3330 1.4023 1.3139 1 2649 1 4886 1 4326 1.2998 1 5582
1 7701 1 5178 1 7084 1 5138 1 7289 1.8672 1 8187 1 5817 1 5528 1.5782 1.5136 1.8551
1 7361 1.5533 1.7142 1.5234 1 7674 1 8099 1 6220 1 6657 1 5279 1 5455 1 5352 1 8029
3 1278 2 2069 2 6099 2 9710 2 6638 3 4002 3 1888 2 3630 2 5767 2 6492 2 6531 3 5599
** CONTINUED ON NEXT PAGE
O
NW
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ABSOLUTE ORGAN WEIGHT DATA (G)
5 WEEK SACRIFICE
HW I 6329-100 PRINTED: ll-OCT-91
PAGE: 3
TABLE INCLUDES: SEX-ALL;GROUP-ALL ;WEEKS-ALL DEATH- 1;SUBSET ALL
SEX DOSE ANIMAL GROUP NUMBER
M 3 C67597 M 3 C67S99 M 3 C67601 NUMBER IN GROUP:
MEAN: STANDARD DEV:
TERMINAL BOOT WT (9 )
310.0 407.5 490.6
15 391.4
32.0
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TE0 - LF. TESTIS, TEI - RT. TESTIS.
BR 2.0027 1 9211 2 1563 15 2.0452
.0966
LI 19.4221 20.7114 21.9925 15 17.9942 2.1294
LU 1.4474 1.5299 1 7051 15 1.4426
.1122
TEO 1.4949 1.7114 1.6701 IS 1.6454
.1241
TEI 1.5569 1 6142 1.7349 15 1.6520
.1059
SO - ACCESS/SEX ORG
SO 2.6560 2.3945 3.3149 15 2.9350
.4016
M 4 C67619 M 4 C67620 M 4 C67625 M 4 C67627 M 4 C67630 M 4 C67631 M 4 C67632 M 4 C67633 M 4 C87636 M 4 C67640 M 4 C67649 M 4 C67654 M 4 C67659
409.2 469.9 371.2 396.2 457.0 391 1 396 5 453.7 395 3 397.0 392.0 333.5 416.0
* CONTINUED ON NEXT PAGE *
2.0962 2.01S4 2.1277 2.0441 2.0449 2.1312 1.9220 2.1741 2 0247 1 9966 2.1367 1.9696 2.1787
26.3509 25.3547 20 1581 20 7728 27 .0511 22.4129 18.2926 25.6081 21 9217 23.9939 21.6322 21.1401 24.7761
1.5621 1.4947 1 5619 1.5105 1.5123 1.4438 1.3554 1.7594 1.5187 1.3627 1 4050 1.2542 1.6564
1.5736 1.5066 1 6535 1.5123 1.6356 1.4199 1 5971 1.7336 1.5013 1.5585 1.6514 1.5679 1.5126
1.5987 1.4394 1 674S 1.5975 1.6673 1.4055 1.5163 1.7207 1 4497 1 5853 1 5671 1 5519 1 4907
2 4021 3 1823 2.6636 2 5701 2 9991 2.9983 2 3953 3 2850 2 4796 2 9113 2 6953 2 7574 2.3142
Oo moo ..
(ianJ
& ?
cv
SC
8LI ~0050 ` IAi
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ABSOLUTE ORGAN WEIGHT DATA (G)
5 WEEK SACRIFICE
HWI 6329-100 PRINTED: ll-OCT-91
PAGE 4
TABLE INCLUDES: SEX-ALL.GROUP-ALL WEEKS-ALL OEATH-1;SUBSET*ALL
SEX DOSE ANIMAL GROUP NUMBER
M 4 C67663 M 4 C6766S NUMBER IN GROUP :
MEAN: STANDARD DEV:
TERMINAL BODY WT (9 )
413.9 317.1
IS 403.3
35.5
BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF. TESTIS. TEI - RT. TESTIS.
BR 2.0214 2.0135 15 2.0604
.0759
LI 21.1079 27.8819 15 23.2303
2.8382
LU 1.4956 1.5150 15 1 4932
.1231
TEO 1.6313 1.7565 15 1.5174
.0916
TE1 1.6523 1.7867 15 1.5104
.1085
SO - ACCESS/SEX ORG
SO 2.3713 2.4346 15 2.6973
.3136
M 5 C87675 M 5 C876S1 M 5 C676I2 M S C67617 M 5 C676I9 M 5 C67690 M 5 C67692 M 5 C67693 M 5 C67996 M 5 C6769I M 5 C67713 M 5 C67715 M 5 C$7717 M 5 C67725 NUMBER IN GROUP :
MEAN: STANDARD DEV:
401.9 372 9 373 0 313.1 392 4 365 2 390.9 402 0 350 6 319 6 373 3 317.1 361.0 346.6
14 371 4
IS.4
2 0451 2.0276 2 1455 2 2291 2 0011 1 9734 2 0512 2.0524 1.8946 2 0041 2.2337 1 9928 2 0368 1 9228 14 2 0437
.0996
29.9112 25.9118 26.9262 22.9772 27.4930 25 5643 26.0918 22.4973 24 8013 23.9691 25.8610 26 0457 25 1598 22.9038 14 25.4377
1.9900
1.4415 1.4507 1.3795 1.4440 1.4362 1 4011 1 6213 1 4325 1 2528 1.3583 1 4625 1.4185 1.3688 1.3277 14 1.4140
.0828
1.5379 1 6282 1 5366 1.5960 1.4394 1 5479 1.7223 1 5361 1.0894 1 6598 1.6587 1.7886 1 6172 1 7531 14 1.5794
.1704
1.5878 1.6029 1.5994 1 7054 1 4378 1 5556 1 7144 1 5114 1 5699 1 6212 1 6381 1 8534 1 6543 1 7120 14 1.6260
.1013
2.7515 2 7151 2 8357 2.4616 2.2318 2 4551 2 8217 3.1287 2 3663 2.8625 2 5155 2 7785 2 2787 2 6365 14 2 6319
.2548
^OOZGO
rwOvi>
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ABSOLUTE ORGAN WEIGHT DATA (G)
5 WEEK SACRIFICE
HWI 6329-100 PRINTED ll-OCT-91
PAGE: 5
TABLE INCLUDES: SEX*ALL;GROUPALL,WEEKS-ALL DEATH*1;SUBSET"ALL
SEX DOSE ANIMAL GROUP NUMBER
M 6 C67726 M C67727 M 6 C67733 M 6 C67735 M 6 C67741 M 6 C67742 M 6 C6774S M 6 C6775I M 6 C67757 M 6 C67759 M 6 C67761 M 6 C67762 M 6 C67764 M 6 C67769 M 6 C67770 NUMBER IN GROUP:
MEAN: STANDARD DEV:
TERMINAL BOOT WT (9 )
371 4 311.9 314.1 3(3 7 393 5 3(6.0 396.0 3(7.0 403.1 402.3 391.9 3 ( ( .( 392.0 402.7 362.5
15 3 ( ( .9
11.1
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - L F . TESTIS, TE1 - RT. TESTIS.
BR 2.0124 2.0154 1.(316 1 9243 1.9496 1.9377 2.0090 2.0547 2 1(07 2.0779 2.06(7 2 0710 1.9914 2.1204 2.0136 15 2.0172
.0(57
LI 16.49(9 15.3142 16.7275 1 7 ,0S6( 15.6120 16.1264 15.1598 14.2522 16.2709 15.2773 15.4561 16.75(5 16.5557 17.3502 13.0996 15 15.(344
1.1305
LU 1.4624 1.6498 1 5339 1.54(2 1.5300 1 .2(00 1.5159 1.5778 1.5378 1.4004 1 4140 1 5928 1 7763 1.7430 1.5011 15 1.5376
.1266
TEO 1.2929 1.6110 1.7651 1.5107 1.6557 1.6971 1.77(3 1.4513 1.61(7 1.5(86 1.5977 1.6769 1.6393 1.6996 1.5705 15 1.6102
.1234
TEI 1 3762 1.5435 1.7714 1.4701 1.7416 1.6902 1.7371 1.4922 1.6308 1.4905 1.5925 1 6002 1 8390 1 7401 1.4(55 15 1.6001
.1212
SO - ACCESS/SEX ORG
SO 2.4971 2.(367 1.6099 2.2190 2.(005 2.(718 2 4131 2 4998 2.9108 1.9775 2 6961 2.6627 2.4532 2.276( 2.6226 15 2 4898
.3579
~$OOZQO
ru-o>j
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ABSOLUTE ORGAN WEIGHT DATA IGl
8 WEEK SACRIFICE
HWI 6329-100 PRINTED ll-OCT-91
PAGE: 1
TABLE INCLUDES: SEX-ALL;GROUP>ALL WEEKS-ALL DEATH- 2:SUBSET-ALL
".EX DOSE ANIMAL GROUP NUMBER
M 1 C674SS M l C674S8 M 1 C67463 M 1 C6746S M 1 C67466 M 1 C67469 M 1 C67472 M 1 C67474 M 1 C87478 M 1 C67480 M 1 C674I1 M 1 C674I4 M 1 C67494 M 1 C87495 M 1 C87498 NUMBER IN GROUP :
MEAN: STANDARD DEV:
TERMINAL BODY WT (g|
483.7 450.9 482.6 422.1 490.3 494.0 516.8 478.1 474.1 459.0 435.1 486.7 452.1 485.5 506.0
15 473.1
26.0
: BR - BRAIN, LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - L F . TESTIS. TE1 - RT. TESTIS
BR 1 9797 2.0532 2.2372 2.1366 2.0832 2.0755 2 0216 2.0492 2.0505 2.1222 2 0951 2.1086 2 1980 2.0187 2.1556 IS 2.0923
.0696
LI 15.5440 16.0617 16.5945 15.6909 19.3228 21.3445 21.0580 17.5871 16.6694 16.4500 15.4762 18.2573 16.7526 18.0970 21.5087 15 17 7610
2.1244
LU 1.6555 1.5344 1.7682 1.4707 1.4311 1.5986 1.5394 1.5651 1.6043 1 3840 1.5414 1.7544 1.6485 1.6654 1.5832 IS 1.5829
.1077
TEO 1.5477 1.8369 1.6595 1.6221 1.5484 1.6613 1.9755 1.7169 1.6764 1.7231 1.5888 1.7484 1.6608 1.6692 1.5765 15 1.6808
.1 1 1 0
TE1 1 5884 1.5900 1 7104 1.7658 1.6178 1 7176 . 1 9855 1.7802 1.6448 1 7252 1.6946 1 7861 1.6441 1.7320 1.5739 15 1.7038
.1052
SO - ACCESS/SEX ORG
SO 2 7615 2.5526 3.5580 2.5484 3.1784 3.0237 3.3550 3.3959 3 4645 2 8279 2 5278 2 9883 3 0165 3.4893 3.3224 15 3.0673
.3617
M 2 C67506 M 2 C67512 M 2 C67S22 M 2 C67S27 M 2 C67531 M 2 C87S32
441.4 440.1 525.9 495.1 524.8 484.2
** CONTINUED ON NEXT PAGE *
2.0323 2.0451 2 0794 2.2223 2.0324 2.0003
15.2133 15.8500 21.9998 16.3032 19.6474 17.3673
1.5973 1 6805 l 5873 1.7484 1 5564 1.3694
1 6841 1 5562 1.7694 1.7954 1.5863 1.7019
1.6619 1 4831 1 7859 1 8030 1.5311 1 7102
3 1538 3 0679 3 3206 3 2105 2 7387 3 0757
o
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A
APPENDIX D INDIVIDUAL ABSOLUTE ORGAN WEIGHT DATA (G)
8 WEEK SACRIFICE
HWI 6329-100 PRINTED U-OCT-91
PAGE 2
TABLE INCLUDES: SEX-ALL;GR0UP-ALL;WEEKS-ALL DEATH-2;SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 2 C67539 M 2 C67540 M 2 C67542 M 2 C67545 M 2 C67546 M 2 C67547 M 2 C675S4 M 2 C67557 M 2 C67560 NUMBER IN GROUP:
MEAN: STANDARD DEV.
TERMINAL BODY WT |g)
510.7 552.7 432.9 436.6 476 9 464.8 496.4 505.0 472 1
15 484 0
36.6
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - L F . TESTIS. TE1 - RT. TESTIS. SO - ACCESS/SEX ORG
BR 2 0356 2.1032 1 9704 2 0517 2 1157 2 1074 2.1668 2.1055 2.0403 IS 2.0739
.0649
LI 17.4985 24.6735 14.9745 16.0053 16.1950 15.3574 19 4081 17.0301 17.4734 15 17 6798 2 7374
LU 1.6069 1.8603 1.5792 1.5610 1.5385 1 6518 1 6152 1 7292 1.5854 15 1.6178
.1110
TEO 1.7637 1.6493 1.6601 1.7831 1.6988 1.5788 1.7070 1.7846 1.5902 15 1.6866
.0921
TEI 1.7937 1.6416 1.7024 1.8184 1 6887 1 6548 1.6770 1 8211 1.5396 15 1 6875
.1076
SO 3 3431 3 0235 2 2701 3 1652 2.7084 2 5313 3 5907 3.6050 3.6806 15 3 0990
.4021
M 3 C87570 M 3 C67578 M 3 C67580 M 3 C67581 M 3 C67582 M 3 C67583 M 3 C67584 M 3 C67585 M 3 C67586 M 3 C67587 M 3 C67594 M 3 C67602
442.7 466.6 441.8 483.8 457 3 453.8 497 1 450.7 413.7 493.0 523 8 504.0
** CONTINUED ON NEXT PAGE **
2 2485 2 0477 2.0828 1 9335 2 1754 2 0247 2 0062 2.0252 2.0816 2.2704 2 0620 2.0978
18 0879 17.5462 19 3210 18 5770 22 3152 18 8334 24 1724 19.3391 15.8206 19.5473 21.2955 20.2097
1 4029 1 5098 1 5312 1 7077 1 5590 1.4036 1.8070 1.5069 1.4648 1 5632 1 6331 1.6142
1.8392 1 7745 1.0539 1.7079 1.5470 1 4218 2 0352 1 5553 1 6005 1.6964 1 7855 1 9214
1 7892 1 6667 1 5651 1 6983 1 5773 1.4119 1 9161 1 5890 1 5758 1 7142 1.7988 1.8826
3 9881 3 2620 3 6804 3.4546 3 1744 3 5708 3 5310 3 0661 3 5940 3 9945 3 9196 3 0233
O'
o?*3
O
riCooJ
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ABSOLUTE ORGAN WEIGHT DATA |G)
I WEEK SACRIFICE
HWI 6329-100 PRINTED: ll-OCT-91
PAGE : 3
TABLE INCLUDES: SEX-ALL.GROUP-ALL;WEEKS-ALL DEATH- 2;SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 3 C67606 M 3 C67612 M 3 C67614 NUMBER IN GROUP:
MEAN: STANDARD DEV:
TERMINAL BODY WT (g|
475.9 489.9 489.4
15 470.9
28.8
: BR - BRAIN. LI - LIVER, LU - LUNG ORGAN ABBREVIATION: TEO - LF . TESTIS. TE1 - RT. TESTIS
BR 2 0932 2.0627 2.0882 15 2.0852
.0881
LI 16.7844 19 6334 19.8089 15 19.4195 2.0972
LU 1.2778 1.5689 1.4582 15 1.5339
.1297
TEO 1.7686 1.6686 1.6205 15 1.6664
.2296
TE1 1.8576 1 6955 1.6179 15 1.6904
.1397
SO - ACCESS/SEX ORG
SO 2.9217 2.9468 3.5666 IS 3.4448
.3649
M 4 C67617
M 4 C67629
M 4 C87634
M 4 CQ703I
M 4 C67639
M M
4 C67642 4 C67644
M 4 CS7646
M 4 C67647
M 4 C6785S
M 4 C876S8
M 4 C876S7
M 4 C67661
428.8 505.2 475 1 488 9 479.0 504.7 456.2 478 8 432.6 479.5 465.4 469.9 412.9
** CONTINUED ON NEXT PAGE
1.9841 2.1037 2 1873 2 1911 2.0544 2.1505 2.0121 2.0739 2 1070 2.1033 2.0411 2 1891 2.1541
22.6410 27.1705 24.6474 26 540S 26.8281 30.2508 21.5018 24.2582 19.5653 23 6742 21.4435 28.9855 17.9125
1.4213 1.5019 1.5054 1.6116 1.4064 1.4758 1.2512 1.7329 1 5717 1.6199 1.3818 1.5997 1 4235
1.5918 1.8013 1.7292 1.4847 1.9760 1.7243 1.8552 1.7144 1 61SS 1.6080 1.9006 2 0112 1.5288
2.4218 1 8955 1.8230 1.4910 2 0156 1.7436 1.8384 1 7213 1.6969 1.5815 1 9595 1 9089 1.5247
3.6044 2.8563 3.0844 3.2086 3.2112 3.0769 3.2252 3.1011 2.7296 3 6047 2.6730 3 2783 2.5689
goozQo
rO4ok
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ABSOLUTE ORGAN WEIGHT DATA (G|
( WEEK SACRIFICE
HWI 6329-100 PRINTED: ll-OCT-91
PAGE 4
TABLE INCLUDES: SEX*ALL;GR0UP*ALL;WEKS*ALL DEATH*2;SUBSET*ALL
SEX DOSE ANIMAL GROUP NUMBER
M 4 C67662 M 4 C67667 NUMBER IN GROUP:
MEAN: STANDARD DEV:
TERMINAL BOOT WT (g)
431 7 494 5
15 466.9
21 7
: BR - BRAIN, LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF . TESTIS. TE1 - RT. TESTIS, SO - ACCESS/SEX ORG
BR 2 0559 2.1607 15 2.1032
.0650
LI 20.0101 25.7940 15 24 0114
3 5791
LU 1 3732 1.4690 15 1.4902
.1217
TEO 1 54(7 1.6719 IS 1.7163
.1649
TEI 1.5113 1.7338 15 1 7911
.2401
SO 3.2091 3.5244 15 3.1306
.31(4
M 5 C676(0 M 5 C67699 M 5 C87702 M 5 C67703 M 5 C67705 M 5 C67707 M 5 C67708 M 5 C67709 M S C67710 M 5 C67711 M 5 C67718 M 5 C67719 M 5 C67721
430 9 451 9 482 * 473 9 4(6 8 497.5 505 364.7 453 1 44(5 479 7 476 3 451.9
m * CONTINUED ON NEXT PAGE *
2 0122 1.9(12 1 9730 2 1139 2.0(59 2 193* 2 2070 2 1310 2 0(12 1 9929 2 1511 2 1768 2 0(55
30.3922 23.6(52 25.0007 27 2361 26.4(25 30.2279 24.6949 23.2540 31.2(47 23 6(96 34 0653 30.95(6 2(54(4
1.5506 1.6440 1.7193 1.6909 1 5050 1 8564 1 5957 1 3(45 1 46(3
.9224 1 5717 1.5670 1.4156
1.55(7 1.7(74 1.5536 1 7440 1.6570 1 7721 1 6074 1.6261 1.(449 1.(353 1 4320 1.6091 1 (756
1 5216 1.6750 1 5152 1 6(16 1 5958 1 7930 1 5917 1 5577 1 67*9 1 (30( 1 5203 1 6220 1 8333
2.(374 2.5243 3.1093 3.1259 2.5926 3.1442 2.6153 2 3407 3.0033 2 4993 2 9666 2 9267 2 (522
00200
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ABSOLUTE ORGAN WEIGHT DATA (G)
< WEEK SACRIFICE
HWI 6329-100 PRINTED: 11-OCT-91
PAGE. 5
TABLE INCLUDES: SEX-ALL;GROUP-ALL;WEEKS-ALL DEATH- 2; SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 5 C67722 M S C87724 NUMBER IN GROUP:
MEAN: STANDARD DEV:
TERMINAL BODY WT (g|
429 * 472.1
IS 459.0
34.2
: BR - BRAIN. LI LIVER. LU - LUNG ORGAN ABBREVIATION: TEO L F . TESTIS. TE1 - RT. TESTIS. SO - ACCESS/SEX ORG
BR 1.9(11 2 1162 15 2.0(55
.0101
LI 25 0187 31.7972 15 27.7557
3.5077
LU 1 5412 1.5794 15 1.5201
.1904
TEO 1.6711 1.7527 IS 1.6115
.1265
TE1 1.6720 1.7111 15 1 8533
.1070
SO 2.9523 3.2795 15 2 1513
.2775
M 6 C6772* M t C67729 M 6 C67731 M 6 C67734 M 6 C87737 M 6 C67739 M 6 C87743 M 6 C87750 M 6 C67752 M 6 C67753 M 6 C67758 M 6 C677S3 M 6 C6776S
43*. t 460 1 44*. 5 416.5 460 5 467.4 43*. 9 441.0 490 0 475 7 445.6 479.9 439.3
CONTINUED ON NEXT PAGE **
2.0153 2 0389 2.023* 2 0770 2 1644 2.1329 2 2613 1.9796 2 1*00 1 9936 2.1977 2.0385 2.1596
16.4515 19.1395 16 1915 15.5695 15.90*1 16.0550 17.6532 15.542* It.719 21.3720 14 8527 18 8615 16.4701
1.3173 1 4*6* 1.6026 1.4530 1.6510 1.4065 1.6951 1 3520 1.5*44 1 8053 1 5914 1.8331 1.7457
1.6152 1.7331 1.7209 1 5371 1.5674 1.4691 1.6251 1 4122 1.7674 1.6930 1.5123 1.7633 1 551*
1.6560 1 6101 1 7494 1.5231 1.5173 1 4418 1.52(9 13.4660EX 1 7356 1 7542 1 6445 1 7636 1.5485
3 6721 3 1071 3.5167 3 0402 3.1*73 2.0103 2 2169 2.6175 2 6611 3 1*31 2.9296 2 4933 2 9217
4oozoo
N-r\U>
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ABSOLUTE ORGAN WEIGHT DATA (G)
I WEEK SACRIFICE
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 6
TABLE INCLUDES: SEX-ALL;GROUP-ALL;WEEKS-ALL DEATH-2;SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 6 C67766 M 6 C67768 NUMBER IN GROUP :
MEAN: STANDARD DEV:
TERMINAL BODY WT (9)
392.4 437.3
15 449.3
24.9
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - L F . TESTIS, TEi - RT. TESTIS. SO - ACCESS/SEX ORG
BR 1.9591 2.0700 15 2.0162
.0907
LI 12.4009 17.7753 15 16.9071 2.2232
LU 1 4526 1.7744 15 1.5615
.1317
TEO 1.5927 1.(269 IS 1.6305
.1177
TEI 1 5825 1.7633 14 1.6335
1111
SO 2.8564 2 7252 IS 2.8806
.4391
&OOZO)
r04\4k>
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ABSOLUTE ORGAN WEIGHT DATA (G)
14 WEEK SACRIFICE
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 1
TABLE INCLUDES: SEX-ALL;GROUPALL:WEEKS-ALL DEATH- T; SUBSET- ALL
SEX DOSE ANIMAL GROUP NUMBER
M I C67454 H 1 C87459 M 1 C67460 M 1 C67462 M 1 C67470 M 1 C67473 M 1 C6747S M 1 C674S2 M 1 C674I5 M 1 0674*7 M 1 C67411 M 1 C67499 M 1 C67501 M 1 C67504 M 1 C67S05 NUMBER IN GROUP :
MEAN: STANDARD DEV:
TERMINAL BODY WT (g)
569.7 495.1 531 9 596.7 519.7 610.5 567.4 511. 595 6 523 4 621 2 577.0 511 0 600.3 54 1
IS 55 7
41 1
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF. tESTIS. TEI - RT. TESTIS. SO - ACCESS/SEX ORG
8R 2 .1 * 22 2.1392 2.4141 2.1057 2.0425 1.9927 2.3230 2.1415 2.2154 2.3102 2.2904 2 2040 2 1*25 2.1334 2.1167 15 2.1914
.1113
LI 20.7919 15.7049 20.9163 11.3191 20.1664 23.9641 20.4091 16.291* 21 0922 17 4732 22.4633 11.5020 11.9192 21.1053 19.6743 15 19.7299
2.2290
LU 1.6464 1.5291 1.6761 1.4199 1 .Siti 1.5642 1.7(91 1.6517 1.9151 1.5735 1.7742 1.6464 1.6017 1.*414 1.5111 IS 1.6543
.1403
TEO 1.7305 1.1054 1 6212 1.7111 1.1097 1.7392 1.9015 1.9007 1.9466 1.7150 1.6540 1 1157 1.5330 1 *1*5 1.613 IS 1.7591
.1174
TE1 1.7609 1.1211 1 6150 1 7438 1.7907 1 7136 1.9175 1.997 1.9120 1.6766 1 6235 1 *021 1 5214 1.7134 1.62*2 15 1 7572
.1126
SO 3 5431 2.90*9 4 1441 4.2601 3.3*56 3 5245 3.5652 3.1952 2 9746 4 220* 3.9901 3.1600 3 3014 2.0144 3 3370 15 3.5217
.4974
M 2 C67S07 M 2 C67S1I M 2 C8T519 M 2 C67S21 M 2 C67S23 M 2 C67526
527 0 467.2 SIS 4 557.6 613 6 513.2
** CONTINUED ON NEXT PAGE "*
3.1322 2.0016 2.1131 2.2002 2.17 2.1591
16.9792 14.0143 16.7043 16.9153 20.1353 15.4771
1.5175 1.3711 1 6032 1.7320 1.7937 1.5033
1 9512 1 6312 1 1623 1.5141 1.(941 1.6993
1.9094 1 7067 1 1267 1 6421 1*579 1 7274
3 1032 3 1439 3.0411 3 4940 3 2076 2.9030
ozoo
no
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A
APPENDIX D INDIVIDUAL ABSOLUTE ORGAN WEIGHT DATA (G)
14 WEEK SACRIFICE
HWI 6329-100 PRINTED U-OCT-91
PAGE 2
TABLE INCLUDES: SEXALL;GROUP-ALL;WEEKS-ALL DEATH- T:SUBSET ALL
SEX DOSE ANIMAL GROUP NUMBER
M 2 C67S33 M 2 C67535 M 2 C67536 M 2 C67S41 M 2 C67S49 M 2 C67551 M 2 C67552 M 2 C67553 M 2 C67556 NUMBER IN GROUP:
MEAN: STANDARD DEV:
TERMINAL BODY WT (g)
MISSINO 549.3 570.3 562 1 609 5 513 4 610 2 560 6 532.3 14 555 1 42 0
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF. TESTIS. TEI - RT. TESTIS, SO - ACCESS/SEX ORG
BR 2.0S36EX 2.1067 2.1616 2 1370 2 2603 2 3262 2 0215 2 1217 2 2605 14 2 2279
.2745
LI 18 5414EX 17.0119 18 4336 16 4604 23.4192 17.3852 23.8634 17.9913 16.9166 14 18 0355 2.8120
LU 1 4960EX 1 .6975 1.6590 1 8520 1 7373 1.5754 1 1710 1.7719 1.4190 14 1 6008
.1886
TEO 1 6960EX 19135 1.8364 1.5904 1.8229 1.7933 2.0816 1.7765 1.5240 14 1.7329
.2279
TEI 1 6749EX 1 9137 1 8860 1.5660 1 8225 l 6257 2.5860 I 7760 1.5304 14 1 8269
.2499
SO 3.5576EX 3.5420 3.0024 3.7892 3 9714 4.3740 3.8105 3.5994 3.7276 14 3.4797
.4298
M 3 C67563 M 3 C67S64 M 3 C67S71 M 3 C67S96 M 3 C67S9S M 3 C67600 M 3 C67603 M 3 C67604 M 3 C67605 M 3 C67607 M 3 C8760I M 3 C67610
631.7 569 9 491 6 5115 534 3 595 1 609 4 556 I 573 2 527 1 500 4 541.1
" CONTINUED ON NEXT PAGE *
2 1397 2.1277 2 1255 2 2403 2 0731 2 2575 2.1709 2.1210 2 2442 2.0524 2.0934 2 4094
26 7202 20 0061 17.3730 20 2379 22 4725 24 7003 22.3081 19 9391 22.2101 17 8774 17.2484 18.4583
1.8608 1 5696 1 4238 1 4079 1 6083 1 7639 1.7242 1.7130 1.6579
9333 1 5348 1.7268
1.8004 1 8240 1 9603 1.6654 1 6629 1.7801 1.6844 1 9040 1.7716 1 8299 1 8529 1.7350
1 7096 1 7241 1 8607 1 6369 1 6661 1 7600 1 6867 1 8820 1 7867 1 8216 1. 7698 1.7383
3 8610 3 9433 4 2992 4 5678 2 8754 3 5697 3 2306 3 4395 3 2634 2 5374 3 2045 4 0026
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ABSOLUTE ORGAN WEIGHT DATA (Gl
14 WEEK SACRIFICE
HWI 6329-100 PRINTED: 11-OCT-91
PAGE: 3
TABLE INCLUDES: SEX-ALL;GROUP-ALL;WEEKS-ALL DEATH-T;SUBSET-ALL
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - L F . TESTIS. TE1 - RT. TESTIS.
SO - ACCESS/SEX ORG
SEX DOSE ANIMAL TERMINAL
GROUP NUMBER BOOT WT 19 J
BR
LI
LU
TEO TEI SO
M 3 C67611 M 3 C67613 M 3 C6761S
529.2 513 2 529.4
2 1143 2.2002 2.1700
1IIIM 21 3304 16.6536
1.4205 1.7412 1.6116
1.6407 1.6462 1.6900
1.7116 1 6651 1.6593
3 9583 3.1016 3.2906
NUMBER IN GROUP: MEAN:
STANDARD DEV:
15 552.7
40.7
15 2.1740 .0196
15 20.4416
2.1657
15 1.5103 .2250
15 1.7767 .1017
15 1.7519 .0772
15 3.5435 .5535
M 4 C67616 M 4 C67618 M 4 C67621 M 4 C67623 M 4 C67624 M 4 C6763S M 4 C67641 M 4 C67643 M 4 C67645 M 4 C67650 M 4 C67652 M 4 C67653 M 4 C676S8
566.8 596.6 807.0 470.7 536.7 544.9 545 4 455.6 621 6 556.3 506 3 592.1 444 1
** CONTINUED ON NEXT PAGE **
2 1783 2.1851 2.2076 2 1070 2 1104 2.0595 1 9354 2 0837 2 2238 2 1319 2 0904 2 0977 2 1339
26 1955 22 8185 25 0527 17 9421 26.4596 20.2688 24.7182 17 6129 24.2640 28 2076 21 0718 28 8583 19.2486
1.6784 1 6356 1 7479 1.5822 1.4814 1.5667 1.2912 1 7374 1 6907 1 7301 1 5510 1.8177 1 5343
2.0033 1 7618 1.6589 1 6761 1.7078 1 8801 1.5795 1.7180 1.9887 1.7603 1 8529 1.8866 1.7072
1.9311 1 7267 1.6305 1.6628 1.7554 1.9577 1.6706 17418 2 0271 1 7022 1 8162 1 8649 1 6782
3.7408 3 9577 2.4959 3 7735 3.3864 3.0409 2.5436 3 7702 3 1797 3.4488 4 0836 3 3819 3 2944
T0ZG9
N -C *
CTl
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ABSOLUTE ORGAN WEIGHT DATA (G|
14 WEEK SACRIFICE
HWI 6329-100 PRINTED U-OCT-91
PAGE: 4
TABLE INCLUDES: SEX-ALL;GROUP-ALL;WEEKS-ALL DEATH-T,SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 4 C67668 M 4 C67669 NUMBER IN GROUP:
MEAN: STANDARD DEV:
TERMINAL BODY WT (9 )
4(4.9 523.5
15 531.2
56 1
: BR BRAIN, LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF. TESTIS, TE1 - RT. TESTIS.
BR 2.0351 2.0615 15 2 .1 0 ( 1
.0724
LI 14.2750 24.0567 15 22.7367
4.2 1 2 (
LU 1.525( 1.5(17 15 1.6101
.1316
TEO 1.6947 1.7(25 15 1.7771
.1216
TE1 1.6942 1.7785 15 1.7759
.1197
SO - ACCESS/SEX ORG
SO 2.90(2 3.6346 15 3.3760
.4782
M 5 C67671
550.6
M M
5 S
C67672 C67673
459.5 501.9
M 5 C67677
532 1
M 5 C67679
437 4
M 5 C676S6 MISSING
M 5 C676SI
412 5
M 5 C67691
405.9
M 5 C6769S
315.9
M 5 C67697
411.7
M 5 C67700
558.6
M 5 C67712
5(3.9
M S C67714
415.5
** CONTINUED ON NEXT PAGE *
2.2213 2.1400 2.3369 2.1273 2.0367 2 1931EX 2 2203 1.9935 2.11(9 2 1143 2.0545 2.2039 2.1574
29.9610 2 0 .0(20 23.3503 23.0049 28.2020 25.94I2EX 25.7541 19 6478 21.7(97 30.4173 34.0432 33.3(05 29.6577
1.71(0 1 4046 1.5036 1.4376 1.5392 1 6253EX 1.4103 1 29(9 1.3370 1 4679 1.7753 1.6121 1.4941
1.9706 1.6796 1.7338 1.6225 1 8515 1 .((43EX 1.5410 1 5029 1.(195 1.8159 2.0474 1.(780 1.6633
l 9721 1 8773 1 70(5 1 6322 1 7670 1 8268EX 1 6223 1.40(9 1 7250 1 (220 1 95(4 1 8628 1 7522
3 50(7 3.3349 3.3(36 2.6019 3.05(4 3.1812EX 2.3(41 2 8857 3.04(8 4 1308 4.1528 4 1255 3 2741
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ABSOLUTE ORGAN WEIGHT DATA |G)
14 WEEK SACRIFICE
HWI 6329-100 PRINTED: U-OCT-91
PAGE: S
TABLE INCLUDES: SEX-ALL;GROUP-ALL;WEEKS-ALL OEATH-T;SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 5 C67716 M S C67720 NUMBER IN GROUP :
MEAN. STANDARD DEV:
TERMINAL BOOT WT (g|
464.7 6St. 1
14 419 1
79.0
: BR - BRAIN, LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF . TESTIS. TE1 - RT. TESTIS. SO - ACCESS/SEX ORG
BR 2.2060 1.9403 14 2.1342
.1044
LI 21.3462 36.3471 14 26.7(46
5.4675
LU 1 5976 1.5044 14 1.5123
.1401
TEO 1.6694 1.7913 14 1.7576
.1547
TEI 1.6342 1.7716 14 1.7373
.1460
SO 2.1111 4.4059 14 3.3647
.6309
M 6 C67730 M 6 C67732 M 6 C67736 M 6 C6773S M 6 C67740 M 6 C67744 M 6 C67746 M 6 C67T4T M 6 C6774I M 6 C67749 M 6 C67754 M 6 C67755 M 6 C677S6
490.1 532 2 516.5 523 1 466.7 503.7 474.3 536.4 503.4 495.6 546 3 473.7 490.0
a CONTINUED ON NEXT PAGE **
2.03(7 2.2336 2.1141 2 1396 2.1000 2.2132 2 1136 2.1360 2 1320 2 1303 2.1798 2 1551 2 0271
16.350( 15.6333 15.(73( 17.0909 15.2555 16.5(20 14.3227 2 0 .(ttt 15.9957 16 2509 It .1(30 13.9650 16.32(5
1.5931 1.5756 1 4705 1 6276 1.3691 l.S76t 1 7241 1.497t 1 6252 1 59(0 1 7299 1 7195 1.5033
1.6753 2.0543 1.7649 1.9505 1 6609 1.6972 1 6021 1 6121 1 6997 1 8322 1.79(4 1 .722t 1.5453
1.6759 1 9(61 1.7359 1.7333 1.6399 1.73(1 1.576t 1.5406 1.7396 1 5716 1 (0(6 1.73(5 1.5535
3 3686 2 244t 3.23(4 3.2127 3 0965 4.6774 3 42(1 3.5361 3 7221 2.t(74 4 4033 2.2(31 3.0065
P0200 *
no
CO
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ABSOLUTE ORGAN WEIGHT DATA f0)
14 WEEK SACRIFICE
HWI 6329-100 PRINTED: 11-OCT-91
PAGE. 6
TABLE INCLUDES: SEX*ALL;GROUP*ALL;WEEKS*ALL DEATH* T;SUBSET* ALL
SEX DOSE ANIMAL GROUP NUMBER
M 6 C67760 M 6 C67767 NUMBER IN GROUP:
MEAN. STANDARD DEV:
TERMINAL BODY WT (g|
496 1 503.9
15 503 S
23.7
' 8R - BRAIN, LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF. TESTIS. TEI - RT. TESTIS, SO - ACCESS/SEX ORG
BR 2.1114 2.2220 15 2.1364
.0594
LI 15 6452 16.1(37 15 16.3033
1.6241
LU 1.6650 1.5364 15 1 5(75
.1016
TEO 1.5640 1.6959 15 1.7117
.13(1
TE1 1.5650 1.7503 15 1.6903
.1204
SO 2.7657 3.0260 15 3.2597
.6635
^TOZ.OO
IN> (O
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ABSOLUTE ORGAN WEIGHT DATA (G
22 WEEK SACRIFICE
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 1
TABLE INCLUDES: SEX-ALL;GROUP-ALL;WEEKS-ALL DEATH-U;SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 1 C674S2 M 1 C67453 M 1 C674S6 M 1 C67471 M 1 C67479 M 1 C674I3 M 1 C67490 M 1 C67493 M 1 C67496 M 1 C67497 NUMBER IN GROUP :
MEAN. STANDARD DEV:
TERMINAL BOOT WT (9 )
564.9 666.3 564.9 653.6 469.7 615.4 610.6 510.4 507.2 597.7
10 576 l
616
: BR - BRAIN, LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - L F . TESTIS, TE1 - RT. TESTIS, SO - ACCESS/SEX ORG
BR 2.1655 2.1363 2.1450 2.2174 2.0754 2.2214 2.0230 2.0441 2 0397 2.2377 10 2.1328
.0822
LI 18.0358 23.8464 17.3831 23.0661 14 3558 19.7955 19 8409 15.5493 15 7533 19.0055 10 18 6432
3.0867
LU 1.6150 1.8553 1 5932 1.6203 1.4853 1.5677 1 6371 1,5130 1.5019 1 5723 10 1 5961
.1050
TEO 1.6436 1.9776 1 4105 1.7540 1.5307 1.7633 1.7820 1.7096 1.7336 1.6288 10 1.6934
.1536
TEI 1.7469 2.0904 1.4101 1 7921 1.5801 1.7407 1.8683 1 8119 1.8395 1.6645 10 1.7544
.1811
SO 4 3278 3 5866 3.5658 3.8614 2 4799 3 7585 3.8663 2.9258 3.2306 3.9372 10 3.5540
.5410
M 2 C6750S M 2 C67513 M 2 C67516 M 2 C67517 M 2 C67520 M 2 C67528 M 2 C67S34 M 2 C67S38
563 4 680.3 678 8 618.8 551 1 567.8 610 9 692.6
* CONTINUED ON NEXT PAGE *
2.1800 2 2957 2.2907 2.2742 2.2930 2.2437 2.1679 2 2904
18.9139 21.4368 19.8095 18.9402 15 6840 17.2706 17 1901 20.1806
1.7534 1 9058 1.9520 1.6369 1 8581 1 5680 1 7502 1.9530
1.5465 1 6522 1 8836 2.0113 1 7258 1 7632 1 8921 1.8505
1.6334 1.7142 1.8377 2.1674 1.7081 1 7366 1 8614 1 7197
3 8153 3.9260 3 2904 4 2763 4 2444 3 6242 3 5869 3 8643
o
rcoon
'
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ABSOLUTE ORGAN WEIGHT DATA (G)
22 WEEK SACRIFICE
HWI 6329-100 PRINTED U-OCT-91
PAGE 2
TABLE INCLUDES: SEXALL GROUP*ALL:WEEKSALL DEATH* U;SUBSET ALL
SEX DOSE ANIMAL GROUP NUMBER
M 2 C67S43 M 2 C6754S NUMBER IN GROUP :
MEAN: STANDARD DEV.
TERMINAL BODY WT (9 )
546.2 560.7
10 607.1
51.1
: BR BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF. TESTIS. TEI - RT. TESTIS,
BR 2.2028 2.2262 10 2.2465
.0498
LI 16 9593 17 9884 10 18.4373
1.7410
LU 1.7226 1.5154 10 1 7415
.1548
TEO 1.4962 1.7379 10 1.7559
.1607
TE1 1.5087 1.7066 10 1 7592
.1739
SO - ACCESS/SEX ORG
SO 2.3864 3.5678 10 3 6582
.5408
M 3 C67561 M 3 C67S67 M 3 C67572 M 3 C67573 M 3 C6757S M 3 C67S79 M 3 C675M M 3 C67SI9 M 3 C67S93 M 3 C67609 NUMBER IN GROUP :
MEAN: STANDARD DEV:
612.6 640.3 553.3 526 7 729 2 517.0 571.7 630.8 709 5 730.9
10 629.2
73 4
2 2294 2 3313 2.2251 2.1454 2.2754 2.1446 2 1857 2.1870 2.0594 2.2589 10 2 2042
.0774
18.9096 18.9256 18.4045 14 1228 22.2539 18.3980 17.7967 21 7957 20.5211 18 0752 10 18.9203 2.2968
1.5853 1 6677 1.7515 1 5733 1 7949 1.6293 1 5797 2 1373 1 5600 1.5208 10 1.6800
.1827
1.3128 1.7847 1.6489 1.7071 2.0338 1.7570 1 5047 2 0235 1.8891 1.7566 10 1.7398
.2194
1.6840 1 8164 1 5651 1 7022 2 0447 1 7759 1 5683 2 1199 1 8484 1.8681 10 1 7991
.1834
4 2129 3.2880 3 3023 3 6631 3.4670 3 8273 3.5672 3 6165 3 7032 3 2434 10 3 5891
2931
M 4 C67622 M 4 C67626 M 4 C67628
563 6 560 2 666.5
** CONTINUED ON NEXT PAGE *
2.1055 2.0641 2.2129
21 3009 18 6121 21.4594
1.5222 1 6345 1.7619
1.8721 1.8775 1.8651
2.0008 1 8955 1 .8660
3 8759 4 2949 4 4556
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ABSOLUTE ORGAN WEIGHT DATA |G)
22 WEEK SACRIFICE
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 3
TABLE INCLUDES: SEX-ALL;GROUP*ALL WEEKS-ALL DEATH-U ;SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 4 C67637 M 4 C87649 M 4 C67651 M 4 C67660 M 4 C67664 M 4 C67666 M 4 C67670 NUMBER IN GROUP:
MEAN: STANDARD DEV:
TERMINAL BODY WT (g)
529.9 601.5 614.9 557 1 694.3 609.1 620.5
10 601.9
51.2
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF . TESTIS, TE1 - RT. TESTIS
BR 2.1437 2.1373 2.1395 2.3756 2.1999 2.2312 2.2129 10 2.1922
.0963
LI 22 6290 17.4747 20.7605 20.6459 20.9493 19.4575 24.0443 10 20.7334
1.9917
LU 1.6904 1 5153 1.6295 1.7257 2.0241 1.6434 1.7924 10 1.6937
.1476
TEO 1.5730 1.2237 1.9009 1.7347 1.6929 1.4773 1.9460 10 1.7055
.2246
TEI 1.6060 1.9322 l 7725 1.7606 1.6949 1.4605 1.9042 10 1.7913
.1655
SO - ACCESS/SEX ORG
SO 3 3451 4 0603 3.2537 3.9045 4.3942 4.0236 4.0490 10 3.9577
.4056
M 5 C67674 M S C67676 M S C6767I M 5 C676I3 M 5 C676I4 M S C67694 M 5 C67701 M 5 C67704
655.4 399.4 552.5 593 0 490.9 595.7 541.9 597.4
** CONTINUED ON NEXT PAGE **
2.2179 2 2129 2.0649 2.1457 2 0711 2.2799 2 0229 2 .0053
21.6330 15 9177 19 4957 17.4599 14 1733 20.0263 19.0290 19.9950
1.6911 1 6120 1.4101 1.5412 1 4541 1.7747 1 8734 1.5265
1.9654 1.7404 1 7275 1.5634 1 6550 1.9411 1.7353 1.6107
1.9093 1.6794 1.7204 1 5733 1 7139 1.7296 1 7266 1.6761
3 9142 4.5674 3.6056 3 6391 2 4774 4 1212 4.9046 3 0959
T0200
rcn-noo
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ABSOLUTE ORGAN WEIGHT DATA (G)
22 WEEK SACRIFICE
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 4
TABLE INCLUDES: SEX-ALL;GROUPALL;WEEKS-ALL DEATH-U:SUBSET ALL
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION. TEO - LF. TESTIS. TEI - RT. TESTIS.
SO - ACCESS/SEX ORO
SEX DOSE ANIMAL TERMINAL
GROUP NUMBER BODY WT (9 )
BR
LI
LU
TEO TEI SO
M 5 C67706 M S C67723
572.9 561.3
2.1126 2.1426
21.5633 16.9016
1.5660 1.6659
1.7092 2.0423
1.6766 1.9492
3.4295 3.2844
NUMBER IN GROUP: MEAN:
STANDARD DEV.
10 556 0
69. t
10 2.1345 .0909
10 16 6190
2.4465
10 1.5919 .1130
10 1.7590 .1509
10 1.7355 .1116
10 3 6939 .8923
gtOZOO
M
in
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL OROAN-TO-BODV WEIGHT PERCENTAGES
5 WEEK SACRIFICE
HWI 6329-100 PRINTED: 11-OCT-91
PAGE: 1
TABLE INCLUDES: SEX*ALL;GROUP*ALL;WEEKS-ALL DEATH-1;SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 1 C67451 M 1 C67457 M 1 C67461 M 1 C67464 M 1 C67467 M 1 C6746I M 1 C67476 M 1 C67477 M 1 C67466 M 1 C874S9 M 1 C67491 M 1 C67492 M 1 C67500 M 1 C67502 M 1 C67503 NUMBER IN GROUP :
MEAN: STANDARD DEV:
TERMINAL BOOT WT (g)
447 6 375 7 409.0 425.9 420.5 391.0 419.9 420.1 397.0 3*2.7 311.1 451.9 401.7 409 0 411*
IS 411.1
21 7
: BR - BRAIN, LI - LIVER. LU - LUNG ORGAN ABBREVIATION; TEO - L F . TESTIS. TE1 - RT. TESTIS. SO - ACCESS/SEX ORG
BR .4919 .550* .51*4 .4101 .5226 .5097 .4942 .4661 .5324 .5550 .4995 .4*09 .49*2 .4955 .4*2* 15 .5053 .0260
LI 3.(570 4.0747 3.9907 4 0519 3 4925 3.7439 3 7770 4.0414 4.10*1 3.*659 3.7161 5.1567 3 *6*3 4.0500 3.7249 15 3.96*0
3714
LU .3909 .379* .3671 .3564 .3914 .39*1 .3319 .3*56 .31*3 .2296 .373* .3774 .3117 .3626 3159 15 .3676 .0413
TEO .3979 .4091 .3*59 .3716 .3767 .4352 .4405 .3369 .3*91 .4773 .3*67 .3*50 .4210 .4072 .3129 15 .4007 .0332
TEI .3919 .4014 .4033 .3175 3722 4544 .4311 .3325 .3902 .456* .3912 .4065 .4216 .4032 .3932 15 .4025 .0309
SO .5129 .7121 .700* .5494 .6123 .6490 .6*93 .5698 .6S 12 .6995 .7029 .7113 .6136 .6365 .6361 15 .6530 .0545
M 2 C67S09 M 2 C67510 M 2 C67511 M 2 C67S14 M 2 C67S1S M 2 C67524
464 S 390.4 399 2 440 2 396.0 376.6
* CONTINUED ON NEXT PAGE **
.4154 .5355 4944 .4716 .4937 .5392
3.7543 3.6547 3.5734 3 6732 3 7729 4 1973
.3634 .4123 .3655 .3613 .3761 .3501
.3719 4221 .4065 .4091 .4017 .3479
3664 4224 .4051 4016 .4027 .3532
.6033 *024 7307 6061 5514 .6737
h iozoo
IOMl
iMADI&S!OJN2.N WISCONSIN U.*S.MA!.RICA- INC
APPENDIX D INDIVIDUAL ORGAN-TO-BODY WEIGHT PERCENTAGES
5 WEEK SACRIFICE
HWI 6329-100 PRINPATGEED' 2ll-OCT-91
TABLE INCLUDES. SEX-ALL GROUP-ALL;WEEKS-ALL OEATH-L.SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 2 C67525 M 2 C67529 M 2 C67530 M 2 C67537 M 2 C67S44 M 2 C67550 M 2 C67555 M 2 C6755 M 2 C67SS9 NUMBER IN GROUP.
MEAN: STANDARD DEV.
TERMINAL BODY WT |g)
434.7 404.5 422.6 359 6 387.7 387.9 422.1 433.7 488.4
15 413.9
34 5
: BR - BRAIN, LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - L F . TESTIS, TEI - RT. TESTIS. SO - ACCESS/SEX ORG
BR .4355 .5363 .5007 .5368 .5219 .5129 .4755 .4943 .4200 15 .4927 .0416
LI 4 0990 3.6443 3.4827 3.5758 3 3495 3.6464 3.7406 4.0486 3.7321 15 3 7297
.2293
LU .3586 .3467 .3688 .4025 .3786 .3983 .3738 .3772 .3313 15 .3710 .0216
TEO .4349 .4364 .3738 .4461 .3975 .3873 .3549 .3850 .3232 15 .3933 .0350
TEI .4279 .4211 .3774 .4541 .4197 .3825 .3533 .3721 .3234 15 .3922 .0350
SO .6260 .6293 .6247 .5605 .6517 .6513 .6541 .6074 .7286 15 .6472 .0657
M 3 C67562 M 3 C67565 M 3 C67S66 M 3 C67568 M 3 C67569 M 3 C67574 M 3 C67576 M 3 C67577 M 3 C67S90 M 3 C6T591 M 3 C67592 M 3 C67595
433 8 390 4 421 7 397 0 389 8 396 8 387 9 363 6 391 4 379.3 341.8 414.9
* CONTINUED ON NEXT PAGE **
4751 .5066 .5002 .4988 5290 5042 .4873 .5654 .5757 .5268 .6369 .4880
4 4689 4 1906 4 6701 4 5189 4 1049 4 0703 4 5038 4 4265 4 3968 4 3939 4 0989 4.6751
.3452 .3807 3499 .3493 .3420 3534 3387 .3534 3798 3777 .3803 .3756
.4080 .3888 .4051 .3813 .4430 .4706 .4173 .4350 3967 .4161 4428 .4471
.4002 .3979 4065 .3837 .4534 4561 4181 4581 3904 4075 .4492 .4345
.7210 .5853 .6189 .7484 .6834 .8S69 8221 .6499 6583 .7512 7762 .8S80
Niinn
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BODY WEIGHT PERCENTAGES
5 WEEK SACRIFICE
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 3
TABLE INCLUDES : SEX-ALL;GROUP-ALL WEEKS-ALL DEATH-1 ;SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 3 C67597 M 3 C67S99 M 3 C67601 NUMBER IN GROUP:
MEAN: STANDARD DEV:
TERMINAL BODY WT (g)
3(0.0 407.5 410.6
IS 39(4
32.0
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - L F . TESTIS. TE1 - RT. TESTIS, SO - ACCESS/SEX ORG
BR .5270 .4733 .44(7 15 .5162 .0474
LI 5.1113 5.0(43 4.5552 15 4.4(46
.3162
LU .3(09 .3752 .3548 15 .3625 .0162
TEO .3934 .4200 .3475 15 .4142 .0310
TEI .4097 .4133 .3610 15 .4160 .0290
SO .69(9 .5(52 .6(97 15 .7122 .0910
M 4 C67619 M 4 C67820 M 4 C67625. M 4 C67827 M 4 C67630 M 4 C67631 M 4 C87832 M 4 C67S33 M 4 C67636 M 4 C67640 M 4 C6784I M 4 0 7654 M 4 C676S9
409.2 489. ( 371.2 396 2 457.0 3(1 1 3(6.5 453.7 385 3 397.0 392.0 333.5 416.0
* CONTINUED ON NEXT PAGE **
.5123 .4290 .5732 51S9 .4474 .5592 .4973 .4792 .5255 .5004 .5451 .5966 .5237
6 4396 5.3969 5.4305 5.2430 5.9193 5.(811 4 7329 5 8443 5 8(95 6 0438 5.51(4 6.33(9 5.9558
.3(17 .3160 .4207 .3(12 .3309 .37(9 .3507 .3(71 .3942 .3432 .35(4 .3761 .39(2
.3(46 .3207 .4454 .3(17 .3579 .3726 .4132 .3(21 .3(96 .3926 .4213 .4701 .3636
.3907 .3064 .4511 .4032 .3648 3688 .3928 3793 3763 .3993 3998 .4653 35(3
.5(70 .6774 .7176 .64(7 .6563 .7867 6197 .7240 .6436 .7333 .6(76 .(26( 5583
riooin
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BOOY WEIGHT PERCENTAGES
5 WEEK SACRIFICE
HWI 6329-100 PRINTED ll-OCT-91
PAGE: 4
TABLE INCLUDES: SEX-ALL;GROUP-ALL ;WEEKS-ALL DEATH- 1 SUBSET- ALL
SEX DOSE ANIMAL GROUP NUMBER
M M
4 4
C67663 C6766S
NUMBER IN GROUP: MEAN:
STANDARD DEV:
TERMINAL BODY WT (9 )
413 9 317.1
IS 403.3
35.5
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF. TESTIS, TEI - RT. TESTIS,
BR .4114 .5192 15 .5142 .0444
LI 5.0991 7.19t 15 5.78*2
.6020
LU .3613 .3607 15 .3713 .0271
TEO .3941 .4529 15 .3962 .0391
TEl .3992 .4607 15 .3944 .0414
SO - ACCESS/SEX ORO
SO .5729 .627 15 .6710 .076
M 5 C67675 M S C67681 M s C676I2 M 5 C67687 M S C676I9 M S C67690 M 5 C67692 M 5 C67693 M 5 C67666 M S C6769I M S C67713 M 5 C67715 M 5 C67717 M S C6772S NUMBER IN GROUP:
MEAN: STANDARD DEV:
401.9 372.9 373 0 313 1 392.4 365.2 390 9 402.0 350 6 319.6 373.3 317. 361 0 346.6
14 371.4
16.4
.5003 .5437 .5752 .5(19 .5101 .5404 .5247 .5105 .5404 .5144 .59(4 .5139 .5842 .554 14 .5409 .0305
7.316 6.94(7 7 211 5 9977 7.0064 7.0001 6.674 5.5963 7 0760 6 1522 6.9277 6.7163 6.9695 6.6011 14 6 7292
.493
.3525 .3(90 .369 .3769 .3680 .3137 .4141 .3503 .3573 .3416 .391 .3651 .3792 .3131 14 .3739 .0111
.3761 .4366 .4120 .4166 .3661 .4231 .4406 .3121 .3107 .4260 .4443 .4612 .4410 .5051 14 .4179 .0475
.3I3 .429 .4211 .4452 .3664 .4260 .43(6 .3760 .447 .4161 .43 .4779 .4513 .4939 14 .430 .0359
.6729 .7211 .7602 .6425 .5705 .6723 .721 .77(3 .6749 .7347 .6739 .7165 .6312 .7607 14 .6956 0579
o o
oc ) '
y.
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BODY WEIGHT PERCENTAGES
5 WEEK SACRIFICE
HWI 6329-100 PRINTED li-OCT-91
PAGE: S
TABLE INCLUDES: SEX*ALL;GROUP*ALL.WEEKS'ALL DEATH*1;SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 6 C67726 M 6 C67727 M 6 C67733 M 6 C67735 M 6 C67741 M 6 C67742 M 6 C6774S M 6 C677S1 M 6 C67757 M 6 C67759 M 6 C67761 M 6 C67762 M 6 C67764 M 6 C67769 M 6 C67770 NUMBER IN GROUP:
MEAN: STANDARD DEV:
TERMINAL BODY WT (9 )
371.4 311.9 314.1 313.7 393.5 316.0 396.0 317.0 403 1 402.3 391.9 311.1 392.0 402.7 362. S
IS 311 9
11 1
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF . TESTIS. TEl - RT. TESTIS.
BR .5411 .5112 .4769 .5015 .4955 .5020 .5073 .5309 .5410 .5165 .5279 .5327 .5010 .5265 .5555 15 .5111 .0207
LI 4.4424 3.9371 4.3550 4.4453 3.9675 4 1771 3 1212 3.6127 4.0364 3 7975 3.9439 4.3103 4.2234 4.3015 3 6137 15 4 0714
2734
LU .3931 .4242 .3993 .4035 .3111 .3316 .3121 .4077 .3115 .3411 .3601 .4097 .4531 .4321 .4141 15 .3955 .0319
TEO .3411 .4142 .4595 .3937 .4201 .4397 .4491 .3750 .4016 .3949 .4077 .4313 .4112 .4221 .4332 IS .4139 .0211
TEI .3705 .3969 .4612 .3131 .4426 .4379 .4311 .3156 .4046 .3705 .4064 .4118 4111 .4321 .4091 15 4113 .0274
SO - ACCESS/SEX ORG
SO .6723 .7294 .4191 .5713 .7117 .7440 .6094 .6459 .7221 .4915 .6110 .6149 .6251 .56S4 .7235 15 .6401 .0943
fzo z o o
roioon
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BODY WEIGHT PERCENTAGES
> WEEK SACRIFICE
HUI 6329-100 PRINTED. 1l-OCT-91
PAGE : 1
TABLE INCLUDES: SEX-ALL;GROUPALL;WEEKS-ALL DEATH-2;SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 1 C674S5 M 1 CB7458 M 1 C87463 M 1 C67465 M 1 C67466 M 1 C67469 M 1 C67472 M 1 C67474 M 1 CC747I M 1 C674IO M 1 C674I1 M 1 C674I4 M 1 C67494 M 1 C8749S M 1 C67498 NUMBER IN GROUP:
MEAN: STANDARD DEV:
TERMINAL BODY WT (g)
463.7 450 9 412.6 422.1 490.3 494.0 S16.8 476.1 474.1 459.0 435.1 466.7 452.1 485.5 506.0
15 473.1
26.0
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF. TESTIS, TE1 - RT. TESTIS. SO - ACCESS/SEX ORG
BR .4269 .4554 .4636 .5062 .4249 .4201 .3912 .4286 .4325 .4624 .4815 .4332 .4862 .4158 .4260 15 .4436 .0311
LI 3.3522 3 5621 3.4386 3.7173 3.9410 4 3207 4.0747 3 6785 3.5160 3.5839 3.5569 3.7512 3 7055 3.7275 4.2507 15 3 7451
.2850
LU .3570 .3403 .3664 .3484 .2919 .3236 .2979 .3274 3384 .3015 .3543 .3605 .3646 .3430 .3129 15 .3352 .0249
TEO .3338 .3630 .3439 .4317 .3158 .3363 .3823 .3591 .3536 .3754 .3652 .3592 .3673 .3438 .3116 15 .3561 .0291
TEI .3425 .3526 .3544 .4183 .3300 .3477 .3642 .3723 .3469 .3759 .3895 .3670 .3637 .3567 .3110 15 .3609 .0258
SO .5955 .5661 .7373 .6037 .6483 .6121 .6492 .7103 .7308 .6161 .5809 .6140 .6672 .7187 .6566 15 .6471 .0557
M 2 C67506 M 2 C67S12 M 2 C67S22 M 2 C67527 M 2 C67S31 M 2 C67532
441 4 440.1 525 9 495 1 524.6 484.2
** CONTINUED ON NEXT PAGE **
.4604 .4647 .3954 .4489 .3873 .4131
3.4466 3 6015 4.1833 3.2929 3 7819 3.5868
.3619 .3818 .3018 .3531 .2966 .2828
.3815 .3536 .3365 .3626 .3023 .3515
.3765 ' .3370
3396 3642 .2917 .3532
.7145 .6971 .6314 .6485 .5219 .6352
O
4 rtno \0
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A
APPENDIX D INDIVIDUAL ORGAN-TO-BOOY WEIGHT PERCENTAGES
8 WEEK SACRIFICE
HWI 6329-100 PRINTED ll-OCT-91
PAGE 2
TABLE INCLUDES: SEX.ALL;GROUPALL;WEEKS*ALL DEATH-2SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 2 C67539 M 2 C67S40 M 2 C67542 M 2 C6754S M 2 C67546 M 2 C67S47 M 2 C675S4 M 2 C67557 M 2 C67560 NUMBER IN GROUP :
MEAN: STANDARD DEV:
TERMINAL BOOT WT (g)
510 7 552 7 432.9 436.6 476.9 464.9 496.4 505 0 472 1
15 414 0
36 6
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - L F . TESTIS. TE1 - RT. TESTIS. SO - ACCESS/SEX ORG
BR .3986 .3805 .4552 .4699 .4436 .4534 .4365 .4169 4322 15 .4304 0298
LI 3 4264 4 4642 3.4591 3 6659 3 3959 3.3041 3 9098 3 3723 3.7012 15 3 6394
.3334
LU .3146 .3366 .3648 .3575 3226 .3554 .3254 .3424 .3358 15 .3355 .0281
TEO .3453 .2984 .3835 .4084 .3541 .3397 .3439 .3534 .3368 15 .3501 .0283
TEI .3512 .2970 .3933 .4165 .3541 .3560 .3378 .3606 .3261 15 .3503 0323
SO .6546 5470 .5244 .7250 .5679 .5446 7233 .7139 7796 15 .6419 0839
M 3 C67570 M 3 C67578 M 3 C67580 M 3 C67591 M 3 C67582 M 3 C67583 M 3 C67584 M 3 C67585 M 3 C87586 M 3 C6758T M 3 C67594 M 3 C67602
442 7 486.6 441 8 483 8 457 3 453 8 497.1 450 7 413 7 493 0 523.8 504 0
* CONTINUED ON NEXT PAGE **
5079 4389 4714 .3996 .4757 4462 .4036 .4493 .5032 .4605 3937 4162
4 0858 3 7604 4 3732 3 8398 4 8798 4.1502 4.8627 4 2909 3 8242 3 9650 4 0856 4 0099
.3169 .3236 .3486 3530 .3409 .3093 .3635 3343 .3541 .3171 .3118 3203
4155 .3803 .2385 .3530 .3383 .3133 .4094 .3451 3869 3441 .3409 3812
4042 3572 .3543 3510 3449 3111 .3855 3526 3809 3477 .3434 3735
.8959 6991 .8330 7141 .6942 .7869 7103 6803 8687 8102 7483 5999
IooN>>
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ORGAN-TO-BODY WEIGHT PERCENTAGES
I WEEK SACRIFICE
HWI 6329-100 PRINTED 11-OCT-91
PAGE: 3
TABLE INCLUDES:
SEX-ALL;GROUP-ALL;WEKS-ALL
DEATH-2.SUBSET-ALL
: BR - BRAIN, LI - LIVER, LU - LUNG
ORGAN ABBREVIATION: TEO - LF . TESTIS. TE1 - RT. TESTIS.
SO - ACCESS/SEX ORG
SEX DOSE ANIMAL TERMINAL
GROUP NUMBER BODY WT (9 )
BR
LI
LU
TEO TEI SO
M 3 C67606
M M
3 3
C67612 C67614
475.9 469.9 419.4
.4391 .4390 .4222
3.5269 4.1762 4.0476
.2685 .3339 .2980
.3716 .3551 .3311
.3903 .3608 .3306
.6139 .6271 .7288
NUMBER IN GROUP : MEAN:
STANDARD DEV:
15 470.9
2 t .6
IS .4445 .0349
15 4.1240 .3702
15 .3261 .0246
15 .3536 .0429
15 .3592 .0242
15 7340 .0900
M 4 C67617 M 4 C67626 M 4 C67634 M 4 C6763I M 4 C67639 M 4 C67642 M 4 C67644 M 4 C67646 M 4 C67647 M 4 C676SS M 4 C676S6 M 4 C67657 M 4 C67661
42 8 505.2 475.1 4SS.9 479.0 504.7 45 2 471.6 432 6 479.5 465.4 469 9 412.9
** CONTINUED ON NEXT PAGE **
.4627 .4164 .4604 .4412 .4269 .4261 .4411 .4333 .4171 .4316 .4316 .4616 .5217
5.2101 5 3762 5 1178 5.4286 5.6009 5 9938 4 7132 5 0682 4 5227 4 9373 4 075 6.1684 4.3382
.3315 .2973 .3169 .3296 .2936 .2924 .2743 .3621 .3633 .3378 .2984 .3404 .344
.3712 .3566 .3640 .2996 .4125 .3416 .4067 .3582 .3741 .3353 .4084 .4280 .3703
.5648 .3752 .3837 .3050 .4208 .3455 .4030 3597 .3923 .3298 .4210 .4062 .3693
.8406 .5654 .6492 .6563 .6704 .6096 .7070 .6480 .6310 .7518 .5748 6977 .6222
rr O
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ORGAN-TO-BOOV WEIGHT PERCENTAGES
I WEEK SACRIFICE
HW1 6329-100 PRINTED: U-OCT-91
PAGE: 4
TABLE INCLUDES: SEX-ALL;GROUP-ALL;WEEKS-ALL DEATH-2.SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M M
4 4
C67662 C67667
NUMBER IN GROUP : MEAN:
STANDARD DEV:
TERMINAL BODY WT (9)
431.7 494.5
15 466.9
26.7
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF . TESTIS, TE1 - RT. TESTIS. SO - ACCESS/SEX ORG
BR .4762 .4369 IS .4519 .0274
LI 4.6352 5.2162 15 5 1384
.5317
LU .3181 .2971 15 .3199 .0271
TEO .3587 .3381 IS .3682 .0342
TEI .3501 .3506 15 .3851 .0598
SO .7435 .7127 15 .6720 .0725
M S C676IO M 5 C67699 M 5 C67702 M 5 C67703 M 5 C67705 M S C67707 M 5 C6770I M S C67709 M 5 C67710 M 5 C67711 M 5 C6771I M S C67719 M 5 C67721
430.9 451.9 462.6 473.9 466.6 497.5 505.6 364.7 453.1 448.5 479.7 476.3 451.9
** CONTINUED ON NEXT PAGE **
.4670 .4384 .4263 .4461 .4285 .4410 .4363 .5843 .4593 .4443 .4484 .4570 4615
7 0532 5 2412 5.4021 5.7472 5.4401 6.0759 4.8823 6.3762 6.9046 5.2820 7.1014 6.4998 6.3174
.3599 .3638 .3715 .3568 .3092 .3329 .3155 .3796 .3241 .2057 .3276 .3290 .3133
.3617 .3955 .3357 .3680 .3404 .3562 .3179 .4459 .4072 .4092 .2985 .3378 .4150
.3531 .3707 .3274 .3549 .3278 .3604 .3147 .4271 3705 .4092 .3169 .3405 .4057
.6585 .5566 .6718 .6596 .5326 .6320 .5171 .6418 .6629 .5573 .6194 .6145 .6312
o
10
o ro 1 0 Na\
<9
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ORGAN-TO-BODY WEIGHT PERCENTAGES
I WEEK SACRIFICE
TABLE INCLUDES: SEX-ALL;GROUP-ALL;WEEKS-ALL DEATH- 2;SUBSET- ALL
SEX DOSE ANIMAL GROUP NUMBER
M S C67722 M 5 C67724 NUMBER IN GROUP:
MEAN: STANDARD DEV:
TERMINAL BOOT WT (g)
429.1 472.1
15 459.0
34.2
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF. tESTIS. TEI - RT. TESTIS. SO - ACCESS/SEX
BR .4609 .4413 15 .4565 .0374
LI 5.1210 6.7353 15 6.0517
.7111
LU .3516 .3345 15 .3321 .0415
TEO .3111 .3713 15 .3699 .0404
TE1 .3190 .3624 15 .3620 .0342
SO .6169 .6947 15 .6225 .0562
M 6 C6772I M 6 C67729 M 6 C67731 M 6 C67734 M 6 C67737 M 6 C67739 M 6 C67743 M 6 C67750 M 6 C677S2 H 6 C67753 M 6 C677SI M 6 C67763 M 8 C67765
439. 480.1 441.5 418.5 460.5 467.4 431.9 441.0 490.0 475.7 445.6 479 9 439.3
* CONTINUED ON NEXT PAGE
.4593 .4425 .4S12 .4917 .4700 .4563 .5152 .4419 .4449 .4191 .4932 .4241 .4916
3 7492 4.3054 3.6101 3.7312 3.4547 3.4350 4 0221 3.4694 3.1514 4.4927 3.2113 3.9303 3.7493
.3162 .3227 .3573 .3419 .3515 .3009 .3162 .3011 .3233 .3375 .3571 .3404 .3974
.3611 .3761 .3137 .3691 .3404 .3145 .3703 .3152 .3807 .3559 .3551 .3674 .3532
.3774 .3646 .3901 .3659 .3295 .3014 .3413 3.0051EX .3542 .3611 .3691 .3675 .3525
.1369 .6743 .7141 .7299 .6921 .4301 .5211 .5143 .5431 .6691 .6575 .5195 .6651
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: S
$ZOZG
IOuMl>
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BODV WEIGHT PERCENTAGES
I WEEK SACRIFICE
HWI 6329-100 PRINTED: 11-OCT-B1
PAGE: 6
TABLE INCLUDES: SEX-ALL GROUP-ALL.WEEKS-ALL DEATH-2;SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 6 C67766 M 6 C6776I NUMBER IN GROUP:
MEAN: STANDARD DEV:
TERMINAL BODY WT |g>
392.4 437.3
15 449.3
24 9
: BR - BRAIN, LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - L F . TESTIS, TE1 - RT. TESTIS. SO - ACCESS/SEX ORG
................................................................................. BR LI LU TEO TEI SO
.4994 .4734
3.1603 4.0641
.3702 .4056
.4059 .4171
.3912 .4032
.7279 .6232
15 .4654 .0292
15 3.7541 .3705
15 .3463 .0325
15 .3636 .0279
14 .3641 .0254
IS .6439 .1090
ro\i>
MADISON, WISCONSIN U.SS.8A!."10* ' INC
APPENDIX D INDIVIDUAL ORQAN-TO-BOOY WEIGHT PERCENTAGES
M WEEK SACRIFICE
HWI 6329-100 PRINPATGEED: 1ll-OCT-91
TABLE INCLUDES: SEX-ALL;GROUP-ALL;WEEKS-ALL DEATH-T;SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 1 C67454 M 1 C674S9 M 1 C6T460 M 1 C67462 M 1 C67470 M 1 C67473 M 1 C6747S M 1 C67482 M 1 C6748S M 1 C67487 M 1 C67488 M 1 C67499 M 1 C67S01 M 1 C67504 M 1 C67505 NUMBER IN GROUP :
WAN: STANDARD DEV:
TERMINAL BODY WT (9 )
569.7 495. S 531.9 596.7 519.7 610.5 567.4 511.6 595.6 523.4 621.2 577.0 511 0 600 3 548.8
15 558 7
41.1
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF . TESTIS. TE1 - RT. TESTIS.
BR .3830 .4315 .4539 .3529 .3930 3264 .4094 .4198 3720 .4548 3687 .3820 .4271 .35S4 3857 15 .3944 .0377
LI 3.0509 3.1676 3.9455 3.0818 3.8804 3.9254 3.5970 3.1846 3 5413 3.3384 3.6161 3.2066 3 7024 3 5158 3.5850 15 3.5293
.2808
LU .2890 .3086 .3152 .2497 .2921 .2562 .3153 .3241 .3333 .3006 .2856 .2853 .3148 .3067 .2755 15 .2968 .0239
TEO .3038 .3641 .3048 .2985 .3482 .2849 .3351 .3714 .3268 .3277 .2663 .3147 .3000 .3029 .2941 15 .3162 0292
TEI .3091 .3674 .3168 .2922 .3446 .2922 .3379 .3712 .3210 .3203 .2613 3124 .2991 2971 .2967 15 .3160 .0296
SO - ACCESS/SEX ORG
SO .6219 .5867 .7792 .7139 .6515 .5773 .6283 .6243 .4994 .8064 .6423 6690 .6461 .4355 .6081 15 6327 .0937
M 2 C67507 M 2 C67518 M 2 C67S19 M 2 C67521 M 2 C67523 M 2 C67526
527 0 467 2 515 4 557 6 613.6 513.2
* CONTINUED ON NEXT PAGE *
.5943 .4299 .4100 .3946 3551 .4208
3 2219 2.9996 3 2410 3 0461 3 3956 3.0158
.2880 .2950 .3111 .3106 .2923 .2929
.3702 3491 .2255 .2841 .3087 .3311
.3623 .3653 .3544 .2945 .3028 .3366
5888 6729 5914 .6266 .5228 .5657
0CO2G3
r\> 0in1
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ORGAN-TO-BODY WEIGHT PERCENTAGES
14 WEEK SACRIFICE
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 2
TABLE INCLUDES: SEX-ALL GROUP-ALL;WEEKS-ALL DEATH-T;SUBSET-ALL
SEX DOSE ANIMAL GROUP NUM8ER
M 2 C67533 M 2 C6753S M 2 C67538 M 2 C67S41 M 2 C67S49 M 2 C675S1 M 2 C67552 M 2 C67SS3 M 2 C67556 NUMBER IN GROUP:
MEAN: STANDARD DEV:
TERMINAL BODY WT |g)
MISSING 549.3 570.3 562.1 609.5 513.4 610 2 560.6 532.3 14 555.1 42.0
: BR - BRAIN, LI - LIVER, LU - LUNG ORGAN ABBREVIATION: TEO - LF . TESTIS. TE1 - RT. TESTIS. SO - ACCESS/SEX ORG
BR LI LU TEO TEI SO
.3139 .3790 .3102 .3706 .3917 .3313 , .3765 .4247 14 .4037 .0613
3.0970 3 2323 2 9319 3 6424 2.9600 3.9106 3 2093 3.1760 14 3.2356
.3001
.3090 .2909 .3295 .2650 .2700 .1919 .3161 ,2666 14 .2692 .0329
.3464 .3220 .2629 .2991 .3074 .3411 .3169 .2663 14 .3124 .0366
.3464 .3307 .2766 .2990 .3129 .4236 .3166 .2675 14 .3295 .0392
.6448 .5265 .6741 .6516 .7497 .6245 .6421 .7003 14 .6273 .0641
M 3 C67563 M 3 C67564 M 3 C67571 M 3 C67S96 M 3 C6759S M 3 C67600 M 3 C67603 M 3 C67604 M 3 C6760S M 3 C67607 M 3 C67606 M 3 C67610
631.7 S69.9 491.6 511.5 534.3 595.1 609.4 556 1 573 2 527.1 500.4 541.1
* CONTINUED ON NEXT PAGE **
.3367 .3733 .4324 .4360 .3660 .3793 .3562 3614 3915 3694 4163 4396
4.2299 3.S105 3 5340 3.9586 4 .2060 4.1506 3.6607 3.5655 3 6746 3.3917 3.4469 3.3677
.2946 .2755 .2696 .2752 .3010 .2964 .2629 .3060 .2692 .1771 3067 .3151
.2650 .3201 .3966 .32S6 .3112 .2991 .2764 .3424 .3091 .3472 .3703 .3165
.2706 .3025 .3765 .3200 3116 2957 .2768 .3384 3117 .3456 .3537 .3172
.6123 .6919 .8745 6930 5382 .5998 .5301 6185 5693 .4814 .6404 .7303
C02G0
foOo>t
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S.A.
APPENDIX D INDIVIDUAL OROAN-TO-BOOV WEIGHT PERCENTAGES
14 WEEK SACRIFICE
HWI 6329-100 PRINTED: U-OCT-91
PAGE: 3
TABLE INCLUDES: SEX*ALL;GROUPALL;WEEKS*ALL DEATH*T:SUBSET*ALL
SEX DOSE ANIMAL GROUP NUMBER
M 3 C67611 M 3 C67613 M 3 C67615 NUMBER IN GROUP:
MEAN: STANDARD DEV:
TERMINAL BOOT WT (9 )
529.2 513.2 529.4
IS 552.7
40.7
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - L F . TESTIS. TE1 - R T . TESTIS,
BR .4124 .3773 .4099 15 .3951 .0296
LI 3.5693 3.6575 3.1135 15 3.6113
.323
LU .2614 .299 .3044 15 .2158 .0329
TEO .3100 .2(26 .3570 15 .3234 .0343
TE1 .3235 .2155 .3512 15 .3119 .030S
SO - ACCESS/SEX ORG
SO .7410 .5311 .6216 15 .6454 .1221
M 4 CB7616 M 4 C6761S M 4 C87621 M 4 C67623 M 4 C67624 M 4 C67635 M 4 C67641 M 4 C67643 M 4 C87645 M 4 C67850 M 4 C67852 M 4 C67853 M 4 C6765*
516 1 596.6 607 0 470.7 536.7 544.9 545 4 455.6 621.6 556.3 506.3 592.1 444.1
* CONTINUED ON NEXT PAGE
.3712 .3629 .3637 .4476 .3932 .3780 .3549 .4574 .357 .3(32 .4129 .3543 4(05
4.4641 3 1241 4 1273 3.1111 4.9301 3 7197 4 5321 3.1659 3.9035 5 0706 4.1619 4.(739 4.3343
.2160 .2742 .2 ( 1 0 .3361 .2760 .2(75 .2367 .3113 .2720 .3110 .3063 .3070 .3455
.3414 .2953 .2733 .3561 .31(2 .3450 .2(96 .3771 .3196 .3164 .3660 .31(6 .3844
.3291 .2194 .26(6 .3533 .3271 3593 .3063 .3123 .3261 .3060 .35*7 .3150 .3779
.6375 .6634 .4112 .1017 .6310 .5511 .4664 .1275 .5115 6200 .1066 .5712 .7411
l
T^ozoo
rO-olg
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BODY WEIGHT PERCENTAGES
14 WEEK SACRIFICE
HWI 6329-100 PRINTEO: 11-OCT-91
PAGE: 4
TABLE INCLUDES: SEX-ALL GROUP-ALL;WEEKS-ALL DEATH-T;SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 4 C6766I M 4 C67S69 NUMBER IN GROUP:
MEAN: STANOARD OEV:
TERMINAL BODY WT (g)
414.9 523. S
15 531.2
56.9
: BR - BRAIN, LI - LIVER, LU - LUNG ORGAN ABBREVIATION: TEO - LF. tESTIS. TEl - R T . TESTIS. SO - ACCESS/SEX ORG
BR .4197 .3931 15 .3954 .0401
LI 2.9439 4.5954 15 4.2106
.5609
LU .3147 .3021 IS .3016 .0349
TEO .3495 .3405 15 .3327 .0322
TEI .3494 .3397 15 .3325 .0321
SO .5999 .6943 15 .6361 .1240
M 5 C67671
550 6
M S C67672
459.5
M 5 C67673
SOI!
M 5 C67677
532.1
M S C67679
437.4
M 5 C676I6 MISSING
M S C676II
412.5
M S C67691
405.9
M 5 C6769S
395.9
M 5 C67697
411.7
M S C67700
SSI 6
M 5 C67712
513.1
M 5 C67714
415 5
** CONTINUED ON NEXT PAGE *
.4047 .4657 .4657 .3991 .4656 .5393 .4911 .5491 .4319 .3679 .3775 .5192
5.2599 4.3704 4.6533 4 3234 6.4476 6 2434 4.1406 5.6465 6 3146 6.0944 5.7171 6.1972
.3122 .3057 .2996 .2702 .3519 .3419 .3200 .3465 .3047 .3179 .2112 .3596
.3579 .3655 .3455 .3049 .4233 .3736 .3703 .4715 .3770 .3665 .3217 .4003
.3512 .3650 .3405 .3067 .4040 .3933 .3471 .4470 .3712 .3506 3191 .4217
.6373 .7259 .6743 .4190 .6992 .5710 .7109 .7900 .1575 .7434 .7067 .7190
CQ2Q3J
rv)
oC\O
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ORGAN-TO-BODV WEIGHT PERCENTAGES
14 WEEK SACRIFICE
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 5
^ sI x a LUGROUP-ALL ;WEEKS.ALL DEATHT;SUBSET*ALL
SEX DOSE ANIMAL GROUP NUMBER
M 5 C67716 M 5 C67720 NUMBER IN GROUP :
MEAN: STANDARD DEV:
TERMINAL BODV WT (a)
464.7 651.1
14 489.1
79.0
m
ORGAN ABBREVIATION: TEO
BRAIN, LI - LIVER, LU - LUNG LF. TESTIS, TE1 - RT. TESTIS.
SO
ACCESS/SEX ORG
BR .4747 .2949 14 .4466 .0713
LI 4.5935 5.5230 14 5 4947
.8403
LU .3438 .2286 14 .3136 .0357
TEO .3635 .2722 14 .3653 .0466
TEI .3517 .2703 14 .3610 .0464
SO .6049 .6695 14 .6910 .0946
M 6 C67730 M 6 C67732 M 6 C67736 M 6 C6773 M 6 C67740 M 6 C67744 M 6 C67746 H 6 C67747 M 6 C6774S M 6 C67749 M 6 C67754 M 6 C6775S M 6 0 7756
490.1 532.2 516.5 523.1 466.7 503.7 474.3 536 4 503.4 495.6 546.3 473.7 490.0
* CONTINUED ON NEXT PAGE *
.4160 .4197 .4093 .4091 .4500 .4394 .4456 .3982 .4235 .4298 .3990 .4550 .4137
3.3362 2.9375 3.0733 3.2872 3.2688 3.2920 3.0198 3.9943 3.1775 3.2790 3.3284 2.9481 3.3323
.3251 .2961 .2847 .3112 .2934 .3130 .3637 .2792 .3228 .3224 .3167 .3630 .3068
.3418 .3860 .3417 .3729 .3559 .3369 .3379 .3005 .3376 .3293 .3292 .3837 .3154
.3420 .3733 .3361 .3314 .3514 .3451 .3324 .2972 .3456 .3171 .3311 .3670 .3170
.6969 .4218 .6270 .6142 .6635 .9286 .7229 .6592 .7394 .5826 .8060 .4920 .0136
'
JCOZGt
rtovo>>
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ORGAN-TO-BODY WEIGHT PERCENTAGES
14 WEEK SACRIFICE
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 6
TABLE INCLUOES: SEXALL;GROUP*ALL;WEEKS*ALL DEATH.T;SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 6 C67760 M 6 C67767 NUMBER IN GROUP:
MEAN: STANDARD DEV:
TERMINAL BODY WT (g)
496.1 503.9
15 503.5
23.7
: BR - BRAIN, LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF. tESTIS. TE1 - RT. TESTIS. SO - ACCESS/SEX ORG
................... ............................................................. BR LI LU TEO TEI SO
.4258 .4410
3 1536 3.2117
.3356 .3049
.3153 .3366
.3155 .3474
.5575 .6005
15 .4250 .0111
15 3.2347 .2274
15 .3159 .0247
15 .3400 .0224
15 .3360 .0218
15 .6470 .1241
o
e CO
rVOoi
0\
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BODY WEIGHT PERCENTAGES
22 WEEK SACRIFICE
HWI 6329-100 PRINTED: ll-OCT-91
PAGE 1
TABLE INCLUDES: SEX*ALL;GROUPALL;WEEKS*ALL DEATH*U,SUBSETALL
SEX DOSE ANIMAL GROUP NUMBER
M 1 C674S2 M 1 C67453 M 1 C674S6 M 1 C67471 M 1 C6747S M 1 C674I3 M 1 C67490 M 1 C67493 M 1 C67496 M 1 C67497 NUMBER IN GROUP :
MEAN: STANDARD DEV:
TERMINAL BODY WT (9)
564.9 666.3 564.9 653.1 419.7 615.4 610.6 510.4 507.2 597.7
10 57*. 1
61.6
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - L F . TESTIS, TE1 - RT. TESTIS, SO - ACCESS/SEX ORG
BR .3169 .3209 3797 .3392 .423* .3610 .3313 .4005 .4021 .3744 10 .3720 .0330
LI 3 1927 3 54*9 3 0772 3 52*0 2.9316 3.2167 3.2494 3.0465 3.1059 3.179* 10 3.2077
.1976
LU .2IS9 .27*4 .2 * 2 0 .2471 .3033 .2547 .26*1 .2964 .2961 .2631 10 2778 .01*7
TEO .2910 .2961 .2497 .26*3 .3126 .2165 .291* .3350 .3418 .2725 10 .2946 .028*
TEI .3092 .3137 .2496 2741 .3227 .2129 .3060 .3550 .3627 .27*5 10 .3054 .0357
SO .7661 .53*3 6312 .5906 .5064 .6107 .6332 .5732 .6369 .6517 10 .6145 .0714
M 2 C8750I M 2 C67513 M 2 C67516 M 2 C67517 M 2 C67520 M 2 C6752I M 2 C67534 M 2 C67S3S
563.4 610 3 67* * 618 551.1 567 * 610 9 692.6
ftft CONTINUED ON NEXT PAGE
.3*69 3375 3375 .3675 .4161 3952 3549 3307
3 3571 3 1511 2.9113 3.0601 2 8459 3.0417 2 1139 2 9137
.3112 2101 .2870 2645 .3009 .2762 .2*65 .2120
.2745 .2429 .2775 .3250 .3132 .3105 .309 7 .2672
2*99 2520 .2707 3503 3099 305* .3047 24*3
6772 5771 .4*47 .6911 7702 63*3 5*72 5579
fycozoo
MJ
HAZLETON LABORATORIES AMERICA. INC MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BOOY WEIGHT PERCENTAGES
22 WEEK SACRIFICE
HWI 6329-IOO PRINTED 11-OCT-91
PAGE 2
TABLE INCLUDES:
SEX-ALL;GROUP-ALL WEEKS-ALL
DEATH-U;SUBSET-ALL
: BR - BRAIN. LI - LIVER. LU - LUNG
ORGAN ABBREVIATION: TEO - LF . TESTIS, TE1 - RT. TESTIS.
SO - ACCESS/SEX ORG
SEX DOSE ANIMAL TERMINAL
GROUP NUMBER BODY WT (9 )
BR
LI
LU
TEO TEI SO
M 2 C67543 M 2 C67548
546.2 560.7
.4033 .3970
3 1050 3.2082
.3154 .2703
.2739 .3100
.2759 .3044
.4369 .6363
NUMBER IN GROUP: MEAN:
STANDARD DEV:
10 607 l
51.1
10 .3727 .0311
10 3.0416 .1717
10 .2175 .0169
10 .2904 .0266
10 .2912 .0306
10 .6057 .0989
M 3 C67561 M 3 C67567 M 3 C67572 M 3 C67573 M 3 C6757S M 3 C67579 M 3 C67588 M 3 C675I9 M 3 C67593 M 3 C67609 NUMBER IN GROUP :
MEAN: STANDARD DEV:
612 640.3 553.3 526.7 729.2 587.0 571.7 630.8 709 5 730 9
10 629.2
73 4
.3638 .3641 .4022 .4073 .3120 .3653 .3823 .3467 .2903 .3091 10 .3543 .0397
3.0858 2.9557 3.3263 2 6814 3.0518 3.1342 3.1129 3.4552 2.8923 2 4730 10 3.0169
.2876
.2587 .2605 .3166 .2987 .2461 .2776 .2763 .3388 .2199 .2081 10 .2701 0408
.2142 .2787 .2980 .3241 .2789 .2993 2632 .3208 .2634 .2403 10 .2781 .0345
.2748 .2837 .2829 .3232 .2804 .3025 .2740 .3361 .2605 .2556 10 .2874 0259
6875 .5135 .5968 .6955 .4755 .6520 .6240 5733 5219 .4438 10 5784 0879
M 4 C67622 M 4 C67626 M 4 C6762S
563 6 560 2 666.5
* CONTINUED ON NEXT PAGE **
.3736 .3685 .3320
3.7794 3 3224 3.2197
2701 .2918 .2644
.3322 .3351 2798
3550 .3384 .2800
6877 7667 6685
&COoO
N
IN>
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORQAN-TO-BOOY WEIGHT PERCENTAGES
22 WEEK SACRIFICE
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 3
TABLE INCLUDES : SEX-ALL;GROUP-AlL.WEEKS-ALL DEATH- U;SUBSET -ALL
SEX DOSE ANIMAL GROUP NUMBER
M 4 C67637 M 4 C67649 M 4 C676S1 M 4 C67660 M 4 C67664 M 4 C67666 M 4 C67670 NUMBER IN GROUP:
MEAN: STANDARD DEV.
TERMINAL BODY WT t9 )
529 9 601 5 614.9 557.1 694.3 609.1 620.5
10 601.1
SI.2
ORGAN
: BR - BRAIN, LI ABBREVIATION: TEO - LF. TESTIS.
LIVER. TEI -
LU RT.
- LUNG TESTIS.
BR .4045 .3553 .3479 .4259 .3167 .3663 .3566 10 .3647 .0320
LI 4.2704 2 9052 3.3762 3 7013 3.0173 3.1945 3.8750 10 3.4661
.4278
LU .3188 2519 .2646 .3094 .2915 .2698 .2889 10 .2921 .0214
TEO .2968 .2034 .2929 .3110 .2424 .2425 .3139 10 .2850 .0431
TEI .3031 .3212 .2983 .3192 .2441 .2399 .3069 10 .2996 .0375
SO - ACCESS/SEX ORG
SO .6313 .6784 .5291 .6821 .6329 .6606 .6525 10 .8590 .0594
M S C67674 M 5 C67676 M S C67678 M S C676I3 M 5 C67614 M 5 C67694 M S C67701 M S C67704
655.4 399.4 552 5 593 0 490 9 595.7 541.6 597.4
** CONTINUED ON NEXT PAGE *
.3364 .5541 .3737 .3616 .4219 .3625 .3733 3357
3.3007 3.9854 3 5286 2 9441 2 8872 3 3618 3 5120 3.3453
.2580 .4036 .2552 .2599 .2962 2979 .3089 .2559
.2999 .4356 .3127 .2636 .3371 3091 .3203 .2696
.2912 .4205 .3114 2653 3491 .2902 .3187 .2806
5972 1.1436
.6526 .6137 .5047 .6918 8866 .5182
$C02GD
Ul
HAZLETON LABORATORIES AMERICA, INC. MAOISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BODY WEIGHT PERCENTAGES
22 WEEK SACRIFICE
HWI 6329-100 PRINTED: U-OCT-91
PAGE: 4
TABLE INCLUDES: SEX-ALL GROUP-ALL WEEKS-ALL DEATH-U;SUBSET-ALL
: BR - BRAIN. LI - LIVER, LU - LUNG ORGAN ABBREVIATION: TEO - L F . TESTIS, TE1 - R T . TESTIS,
SO - ACCESS/SEX ORG
SEX DOSE ANIMAL TERMINAL ................................................................................
GROUP NUMBER BODY WT (9 )
BR
LI
LU
TEO TE1 SO
M 5 C67706 M 5 C67723
572.9 561.3
.3110 .3811
3.7639 3.0124
.2737 .2961
.2963 .3639
.2930 .3473
.5916 .5151
NUMBER IN GROUP: MEAN.
STANDARD DEV:
10 556.0
69.
10' .3904 .0624
10 3.3642 .3531
10 .2906 .0447
10 .3210 .0499
10 .3187 0455
10 .6792 .1950
o
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ORGAN-TO-BRAIN WEIGHT RATIOS
5 WEEK SACRIFICE
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 1
TABLE INCLUDES: SEX-ALL;GROUP*ALl;WEEKS-ALL DEATH- 1;SUBSET- ALL
SEX DOSE ANIMAL GROUP NUMBER
MM
1 1
C674S1 C67457
M 1 C67461
M 1 C67464
MMM
1 1 1
C67467 C67468 C67476
M 1 C67477
MM
M
MM
M M
1111111
CCCCCCC66666667777777S44S544OIS90906O19322
NUMBER IN GROUP : MEAN:
STANOARD DEV:
TERMINAL BODY WT (9 )
447.6 375.7 409.0 42S.9 420 5 39. 0 419.9 420.1
33434449S110507111219.......1177900 4121151 71
: BR - BRAIN, LI - LIVER. LU - LUNG
ORGAN ABBREVIATION: TEO - LF. TESTIS, TEI - RT. TESTIS,
BR
1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000
1111111......0000000000000000000000000000 151 ..000000 00
LI
7.1411 7.3910 7 8976 4267 6 6125 7.3446 7.6429
10677717...69747771764612171604543362607595 157 ..19130520
LU .7947 .696 .7011 .7413 .7490 .7110 .685
.......7477777*31192241309974(312333I IS ..70390699
TEO .0(9 .742 .7444 .7(74 .720 .153 .913
.....7177703679422003504127111009 15 ..70594312
TEI
.7967 .72(7 .7779 .059 .7122 .1914 .1723
.....1771(17411324116332354312692334 15 .70957612
SO - ACCESS/SEX ORG
SO 1 1(50 1.2929 1.3517 1.1426 1.3055 1.2731 1 394
11111111.......2244322222091361237311041121546 IS1 .02991265
M M M M M M
222
2 2 2
CCCCCC668666777777555555012111954041
333434879984469006 .....62240
** CONTINUED ON NEXT PAGE *
1111 ...000000000000 0000
1.0000 1.0000
967777 ...6620*774232472154116244
......7776177354760949411193
.. 17 91 5( 24 ...1<6541265321262
....16<73521(tS29505211977 111111 144224357649127691141446
G0204
i\> in
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BRAIN WEIGHT RATIOS
5 WEEK SACRIFICE
HUI 6320-100 PRINTED: ll-OCT-91
PAGE. 2
TABLE INCLUDES: SEX.ALL.GROUP-ALL.WEEKS-ALL DEATH-1,SUBSET-ALL
: BR - BRAIN, LI - LIVER, LU - LUNG ORGAN ABBREVIATION: TEO - LF . TESTIS. TE1 - RT. TESTIS.
SO - ACCESS/SEX ORG
SEX DOSE ANIMAL TERMINAL
GROUP NUMBER BODY WT (9 )
BR
LI
LU
TEO TEI SO
M 2 C67525 M 2 C67S29 M 2 C67S30 M 2 C67537 M 2 C67S44 M 2 C67S50 M 2 C6755S M 2 C6755 M 2 C675S9
434.7 404.5 422.6 359.6 317.7 3(7 9 422 1 433.7 4M. 4
1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000
9.4123 6 7950 6 9552 6 6614 6.41(0 7.10(9 7.(663 (.1900 (.8(56
(235 .6465 .7366 .7498 .7254 .7765 .7(60 .7630 .78(8
.99(7 (137 .7464 .8310 .7617 .7551 .7464 .77(9 .7694
.9(25 .7(51 .7537 .8460 .8041 .7456 .7430 .7528 .7701
1.4374 1.1734 1 2475 1 0442 1 24(7 1 2698 1.3755 1 .22 (8 1.7347
NUMBER IN GROUP : MEAN:
STANDARD DEV:
15 413.9
34.5
IS 1.0000 .0000
15 7.6323 .9170
15 .7564 .0575
15 .8015 .0794
15 .7990 .0742
IS 1.3224 .1743
M 3 C67S62 M 3 C6756S M 3 C67566 M 3 C6756I M 3 C67569 M 3 C67574 M 3 C67S76 M 3 C67577 M 3 C67S90 M 3 C67591 M 3 C67592 M 3 C67595
433 a
390.4 421.7 397.0 319 a 396 .a 387 9 363.6 391.4 379.3 341.a 414.9
1.0000 1.0000 1.0000 1 0000 1 0000 1 0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000
9.4062 ( 2728 9.3371 9 0602 7.7598 ( 0723 9 2426 7 (2(6 7.6369 (.3413 6.4358 9.5(01
.7266 .7516 6996 .7003 .6465 .7009 .6951 .8250 .6597 .7170 .5971 .7696
.85(9 .7675 .8100 .7645 .8375 .9332 .8564 .7893 .6(91 .7(99 .6953 .9182
.8424 7(54 (127 .7694 .8571 .9046 (5(1 .8102 .67(0 .7735 .7052 .8905
1.5178 1 1159 1 2374 1 5004 1.2919 1 6994 1 .6(70 1 1494 1 1435 1.4260 1 .2 1 ( 8 1.75(2
** CONTINUED ON NEXT PAOE * e> vJ ON
Ol
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BRAIN WEIGHT RATIOS
S WEEK SACRIFICE
HWI 6329-100 PRINTED- ll-OCT-91
PAGE! 3
TABLE INCLUDES: SEX-ALL;GROUP-ALL;WEEKS-ALL DEATH-1;SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 3 C67597 M 3 C67599 M 3 C67601 NUMBER IN GROUP :
MEAN: STANDARD DEV.
TERMINAL BOOT WT (g|
310.0 07.5 410.6
15 391.4
32.0
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - L F . TESTIS, TE1 - RT. TESTIS, SO - ACCESS/SEX ORG
BR 1.0000 1.0000 1.0000 15 1.0000
.0000
LI 9.6913 10.7416 10.1521 15 1 7711 1 1310
LU .7227 .7927 .7901 15 .7083 .0573
TEO .7464 .6173 .7745 15 .1084 .0739
TE1 .7774 .1732 .8046 15 .8095 .0644
SO 1.3262 1.2363 1.5373 15 1.3897
.2163
M 4 C67619 M 4 C67620 M 4 C67625 M 4 C67627 M 4 C67830 M 4 C67631 M 4 C67632 M 4 C67633 M 4 C67636 M 4 C67640 M 4 C6764I M 4 C67654 M 4 C67659
409.2 469 8 371.2 396.2 457 0 381.1 386.5 53 7 385 3 397.0 392.0 333 5 416.0
a CONTINUED ON NEXT PAGE *
1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1 0000 1.0000 1.0000 1.0000 1.0000 1.0000
12.5708 12.5805
9.4741 10.1623 13.2292 10.5166
9 5175 11.7787 10.8271 12.0779 10.1241 10.6253 11.3720
.7452 .7367 .7340 .7390 .7396 .6775 .7052 .8093 .7501 6859 .6576 .6304 .7603
.7507 .7475 .7771 .7398 .7999 .6662 .8310 .797 .7415 .7845 7729 .7880 .6943
.7627 .7142 .7870 .7815 .8154 .6S95 .7900 .7915 .7160 .7980 .7334 .7800 .6842
1.1459 1.5790 1.2519 1.2573 1 4667 1.4069 1 2463 1.5110 1 2247 1 4655 1.2614 1 3859 1 0622
NMJ
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BRAIN WEIGHT RATIOS
5 WEEK SACRIFICE
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 4
TABLE INCLUOES: SEX-ALLGROUP-ALL:WEEKS-ALL DEATH-l;SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 4 C67663 M 4 C6786S NUMBER IN GROUP :
WAN: STANDARD DEV:
TERMINAL BODY WT (91
413.9 317.1
IS 403.3
35.5
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - L F . TESTIS. TEi - R T . TESTIS. SO - ACCESS/SEX ORG
BR 1.0000 1.0000 15 1.0000
.0000
LI 10 4422 13.1475 15 11.2764
1.3499
LU .7399 .7S24 15 .7242 .0452
TEO .8070 .8724 15 .7713 .0513
TEI .8174 .8874 15 .7679 .0580
SO 1.1731 1.2091 15 1.3098
.1497
M 5 C87675 M S C676I1 M 5 C676I2 M 5 C676I7 M 5 C676I9 M S C67890 H S C67892 M S C87893 M 5 C876B8 M 5 C6789I M S CB7713 M 5 C67715 M 5 C67717 M S C67725 NUMBER IN GROUP :
MEAN: STANDARD DEV:
409.9 372.9 373.0 313.1 392.4 365.2 390.9 402.0 350.6 319.6 373 3 317 1 381.0 346.6
14 378.4
11.4
1.0000 1.0000 1.0000 1 0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000
14 1.0000 .0000
14.6242 12.7795 12.5501 10.3078 13.7341 12.9544 12.7203 10 9615 13 0942 11.9600 11.5777 13.0699 12.3526 11.9117 14 12 4713
1.0996
.7046 .7155 .6430 .6478 .7175 .7100 .7904 .6980 .6612 .6778 .6547 .7118 .6720 .6905 14 .6925 .0383
.7517 .8030 .7162 .7180 .7191 .7844 .8397 .7414 .5750 .8282 .7426 .8975 .7940 .9117 14 .7734 .0852
.7761 .7905 .7455 .7651 .7183 .7883 .8358 .7364 .8286 .8089 .7334 .9300 8122 .8904 14 .7971 .0604
1 3450 1.3391 1.3217 1.1043 1.1184 1.2441 1.3756 1.5244 1.2490 1.4283 1.1262 1.3943 1 1188 1.3712 14 1.2900
.1328
gi.-ozoy
rs) oo
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ORGAN-TO-8RAIN WEIGHT RATIOS
5 WEEK SACRIFICE
HWI 6329-100 PRINTED: 11-OCT-91
PAGE. S
TABLE INCLUDES:
SEX-ALL;GROUP-ALL;WEEKS-ALL
DEATH-1SUBSET-ALL
: 6R - BRAIN. LI - LIVER. LU - LUNG
ORGAN ABBREVIATION: TEO - LF . TESTIS. TE1 - RT. TESTIS.
SO - ACCESS/SEX ORG
SEX DOSE ANIMAL TERMINAL
GROUP NUMBER BODY WT (9 )
BR
LI
LU
TEO TEI SO
M 6 C67726 M 6 C67727 M 6 C67733 M 6 C67735 M 6 C67741 M 6 C67742 M 6 C67745 M 6 C67751 M 6 C67757 M 6 C67759 M 6 C67761 M 6 C67762 M 6 C67764 M 6 C67769 M 6 C67770
371.4 311.9 384.1 383.7 393.5 386.0 396.0 387.0 403.1 402.3 391.9 388.8 392.0 402.7 362 5
1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1 0000 1.0000 1 0000 1.0000 1.0000
8.1986 7 5986 9.1327 8 8639 8.0070 8 3224 7 5459 6.9364 7.4613 7.3523 7 4714 8 0920 8.3136 8 1825 6.5056
.7287 .8186 .8375 .8046 .7847 .6606 .7546 .7679 .7052 .6739 .6835 .7691 .8920 .8220 .7455
.6425 .7993 .9637 .7851 .8492 .8758 .8852 .7063 .7423 .7845 .7723 .8097 .8232 .8015 .7799
.6839 .7659 9671 .7640 .8932 .8723 .8650 .7282 .7478 .7173 .7698 .7727 .8230 .8206 .7377
1.2409 1.4075
.8790 1.1531 1.4363 1 4921 1 2011 1.2166 1.3348
.9517 1.3033 1 2957 1.2319 1 0738 1.3024
NUMBER IN GROUP: MEAN:
STANDARD DEV:
15 388 9
11 1
15 1.0000 .0000
15 7.8656 .6950
15 7631 .0659
15 .8000 .0767
15 7951 .0771
15 1 2333 .1678
zoo
IV )
10
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ORGAN-TO-BRAIN WEIGHT RATIOS
I WEEK SACRIFICE
HWI 6329-100 PRINTED: U-OCT-91
PAGE. 1
TABLE INCLUOES:
SEX-ALL;GROUP-ALL;WEEKS-ALL
DEATH-2 iSUBSET-ALL
: BR - BRAIN. LI - LIVER, LU - LUNG
ORGAN ABBREVIATION: TEO - LF. TESTIS, TEI - RT. TESTIS.
SO - ACCESS/SEX ORG
SEX DOSE ANIMAL TERMINAL
GROUP NUMBER BOOT WT (9 )
BR
LI
LU
TEO TE1 SO
M M
1 1
C67455 C6745
M 1 C67463
M 1 C6746S
M 1 C67466
M 1 C67469
M 1 C67472
M 1 C67474
M 1 C67478
M 1 C67480
M 1 C67481
M 1 C674I4
M 1 C67494
M 1 C6749S
M 1 C67496
463.7 450 9 412.6 422.1 490.3 494.0 516 6 478.1 474.1 459.0 435.1 486.7 452 1 415 5 506.0
1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000
7.8517 T .8226 7.4175 7.3439 9 2755 10.2940 10.4165 8.5824 8.1294 7 7514
78 .36856859
7 6217 8 9647 9.9781
.8362 .7473 .7904 .8883 .6870 .7702 .7615 .7639 .7824 .6522 .7357 .8320 .7500 .8250 .7345
.7818 .7972 .7418 .8528 .7433 .8004 .9772 .8378 .8176 .8119 .7583 .8292 .7555 .8269 .7314
.8023 .7744 .7645 .8264 .7766 .8276 .9821 .8687 .8021 .8129 .8089 .8471 .7480 .8580 .7301
1.3949 1 2432 1.5904 1.1927 1.5257 1 4569 1 6596 1.6572 1.6898 1.3325 1.2064 1.4172 1 3724 1 7295 1.5413
NUMBER IN GROUP : MEAN:
STANDARD DEV:
15 473 1
26.0
15 1 0000 .0000
15 8 4990 1.0685
15 .7571 .0536
15 .8042 .0614
15 .8153 .0608
15 1 4672 .1780
M 2 C67506 M 2 C67512 M 2 C87522 M 2 C67527 M 2 C67S31 M 2 C67532
441 4 440 1 525.9 495 1 524 8 484.2
** CONTINUED ON NEXT PAGE **
1.0000 1.0000 1.0000 1.0000 1.0000 1.0000
7.4859 7.7502 10.5799 7.3362 9 7655 8 6823
7860 .8217 .7633 .7868 .7658 .6846
.8287 .7609 .8509 .8079 .7805 .8508
.8177 7252 8589 .8113 .7533 .8550
1 5518 1 5001 1 5969 1 4447 1 3475 1.5376
fO Z O O
M00 o
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BRAIN WEIGHT RATIOS
WEEK SACRIFICE
HWI 6329-100 PRINTED: ll-OCT-91
PAGE : 2
TABLE INCLUDES: SEX-ALL;GROUP-ALL.WEEKS-ALL DEATH- 2;SUBSET ALL
SEX DOSE ANIMAL GROUP NUMBER
M 2 C67539 M 2 C67540 M 2 C67S42 M 2 C6754S M 2 C67546 M 2 C67547 M 2 C67554 M 2 C67SS7 M 2 C67580 NUMBER IN GROUP:
MEAN: STANDARD DEV:
TERMINAL BODY WT (9)
S10.7 552.7 432.9 438 6 476.9 464.8 496.4 505.0 472.1
15 484.0
36.6
: BR - BRAIN, LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - L F . TESTIS, TEI - RT. TESTIS, SO - ACCESS/SEX ORG
BR 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 15 1.0000
.0000
LI 8.5962 11.7314 7.5997 7 8010 7.6547 7.2874 8.9570 8.0884 8.5641 15 8 .S2S3 1.2877
LU .7894 8845 .8015 .7608 .7272 .7838 .7454 .8213 ,7770 15 7799 .0455
TEO .8664 .7842 .8425 .8691 .7982 .7492 .7878 .8476 .7794 15 .6136 .0395
TE1 .8812 .7805 .8640 .8863 .7982 .7852 .7740 8649 .7546 15 .8140 .0517
SO 1.6423 1.4376 1 1521 1.5427 1.2801 1 2011 1.6571 1.7122 1.8040 15 1.4939
.1863
M 3 C67S70 M 3 C6757I M 3 C67SI0 M 3 C675I1 M 3 C67582 M 3 . C67583 M 3 C67584 M 3 C6758S M 3 C67586 M 3 C67S87 M 3 C67594 M 3 C67602
442.7 466.6 441 8 483 8 457.3 453 8 497 1 450.7 413.7 493.0 523.8 504.0
CONTINUED ON NEXT PAGE **
1.0000 1.0000 1.0000 1.0000 1 0000 1.0000 1.0000 1.0000 1 0000 1.0000 1.0000 1.0000
8.0444 8.5887 9 2773 9.6080 10.2580 9.3018 12.0489 9.5492 7 6002 8.8096 10.3278 9.6338
.6239 .7373 .7352 .8832 .7166 .6932 .9007 .7441 .7037 .6885 .7920 .7695
.8180 .8666 .5061 .8833 .7111 .7022 1 0145 .7680 .7689 7472 .8659 .9159
.7957 .8139 7515 .8784 .7251 .6973 .9551 .7846 .7570 7550 .8724 .8974
1.7639 1.5930 1 7672 1 7867 1 4592 1.7636 1.7600 1 5140 1 7266 1 7594 1 9009 1 4412
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORQAN-TO-BRAIN WEIGHT RATIOS
t WEEK SACRIFICE
HWI 6329-100 PRINTED: 11-OCT-91
PAGE. 3
TABLE INCLUDES:
SEX-ALL;GROUP-ALL WEEKS-ALL
DEATH-2;SUBSET-ALL
: BR - BRAIN, LI - LIVER. LU - LUNG
ORGAN ABBREVIATION: TEO - L F . TESTIS. TE1 - RT. TESTIS. SO - ACCESS/SEX ORG
SEX DOSE ANIMAL TERMINAL
GROUP NUMBER BOOT WT (9 )
BR
LI
LU
TEO TE1 SO
M 3 C67606 M 3 C67612 M 3 C67614
475.9 469.9 419.4
1.0000 1.0000 1.0000
9.01(5 9 5113 9 5971
.6105 .7606 .7057
.9449 .90(9 .7(43
.9(74 .9220 .7(30
1.3951 1.42(6 1.7262
NUMBER IN GROUP: MEAN:
STANDARD DEV:
IS 470.9
29.6
15 1.0000 .0000
15 9.3301 1 1031
15 .7377 .0795
15 .9004 .1154
15 .9117 .0727
15 1.6524 1631
M 4 C67617 M 4 C67629 M 4 C67634 M 4 C97639 M 4 C67639 M 4 C67642 M 4 C67644 M 4 C67646 M 4 C67647 M 4 C67655 M 4 C67656 M 4 C87657 M 4 C67661
429.9 505 2 475 1 499.9 479.0 504 7 456 2 479.6 432 6 479.5 465.4 469.9 412.9
** CONTINUED ON NEXT PAGE
1.0000 1.0000 1.0000 1.0000 1.0000 1 0000 1 0000 1.0000 1 0000 1 0000 1 0000 1 0000 '.0000
11.4112 12.9156 11.26(4 12.1129 13.0599 14.0669 10 6(82 11.6959
9.2(59 11 2557 10.5059 13.3629
(.3155
.7183 .7139 .6(92 .7355 .6(46 .8(63 .6219 .9356 .7459 7702 .6(04 .7375 .6609
.9022 .9563 .7906 .66(5 .9619 .9019 .9220 .9267 .76(2 .7645 .9312 .9272 .7097
1 2206 .9010 .9334 .6(05 .9(11 .9109 .9137 .9300 (054 .7519 .9600 9(00 .7079
1.(166 1.3579 1.4101 1.4644 1 5631 1.4309 1 6029 1.4953 1 2955 1.7139 1.3106 1 5114 1.1926
O
ow IS> CrDo
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BRAIN WEIGHT RATIOS
t WEEK SACRIFICE
,
HUI 6329-100 PRINTED ll-OCT-91
PAGE: 4
TABLE INCLUDES: SEX-ALL;GROUP-ALL;WEEKS-ALL DEATH-2SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 4 C67662 M 4 C67667 NUMBER IN GROUP :
MEAN: STANDARD DEV:
TERMINAL BOOT WT |g)
431.7 494.5
IS 466 9
26.7
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF. TESTIS. TE1 - RT. TESTIS. SO - ACCESS/SEX ORG
BR 1.0000 1.0000 15 1.0000
.0000
LI 9.7330 11.9378 IS 11.4408 1.5808
LU .6679 .6799 15 .7083 .0518
TEO .7533 .7738 15 .8172 .0864
TEI 7351 .8024
15 .8543 .1342
SO 1.5613 1.6311 15 1.4905
.1662
M 5 C67680 M S C67699 M 5 C67702 M S C67703 M 5 C67705 M 5 C87707 M S C6770I M 5 C67708 M 5 C67710 M 5 C67711 M 5 C6771 M 5 C67719 M 5 C67721
430 9 4SI .9 462.8 473.9 486.1 497.5 505.8 364.7 453.1 448 5 479 7 476.3 451.9
** CONTINUED ON NEXT PAGE *
1.0000 1 0000 1.0000 1 0000 1.0000 1.0000 1.0000 1 0000 1 0000 1.0000 1.0000 1.0000 1.0000
15 1040 11 9550 12.6714 12.8843 12.6960 13.7787 11 1894 10.9122 15.0320 11 8870 15.8362 14 2221 13 6890
.7706 .8298 .8714 .7999 .7215 .7550 .7230 .6497 .7055 .4628 .7306 .7199 .6788
.7746 .9022 .7874 .8250 .7944 .8078 .7283 .7831 .8865 .9209 .6657 .7392 .8994
.7S62 .8454 .7680 .7955 .7850 .8173 .7212 .7310 .8067 .9187 .7068 .7451 .8791
1 4101 1.2741 1.5759 1 4787 1 2429 1.4332 1.1850 1 0984 1.4431 1.2541 1 3791 1 3445 1 3676
$TrOZQQ
ICNDJ
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BRAIN WEIGHT RATIOS
1 WEEK SACRIFICE
HWI 6329-100 PRINTED: 11-OCT-91
PAGE: 5
TABLE INCLUOES: SEX-ALL GROUP-ALL WEEKS-ALL DEATH-2 ;SUBSETALL
SEX DOSE ANIMAL GROUP NUMBER
M S C6T722 M 5 C67724 NUMBER IN GROUP :
MEAN: STANDARD DEV:
TERMINAL BOOT WT (g)
429.1 472.1
IS 459.0
34.2
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF. TESTIS. TEI - RT. TESTIS. SO - ACCESS/SEX ORG
BR 1.0000 1.0000 15 1 OOUO
.0000
LI 12 6217 15.0256 15 13.300*
1.5175
LU .77*0 .7463 15 .7295 .0929
TEO *435 .82*2
15 <111 .0722
TEI .1440 016 15 .7939 .0604
SO 1.4902 1 5497 IS 1 36*5
.1361
M e C6772I M 6 C67729 M 6 C67731 M 6 C67734 M 6 C67737 M 6 C67739 M 6 C67743 M e C67T50 M 6 C677S2 M 6 C67753 M 6 C6775I M 6 C67763 M 6 C6776S
43 * 460. S 44*. 5 416.5 460.5 467 .4 431.9 441.0 490.0 475 7 445.6 479.9 439.3
CONTINUED ON NEXT PAGE
1.0000 1 0000 1.0000 1.0000 1.0000 1.0000 1.0000 1 0000 1.0000 1.0000 1.0000 1.0000 1.0000
8.1633 9.7305 *.0005 7.4961 7.3502 7 5273 7.(067 7 *515 I 6568 10.7203 6.6673 9 2S26 7.6261
.6114 .7292 .7919 .6996 .7621 .6594 .7496 .6130 .7261 *052 .7241 *015 .*0*3
*015 .*500 .1503 .7401 .7242 .6191 .71*7 .7134 *107 *492 .7200 .1650 .71*6
.1217 .1240 .1644 .7337 .7010 .6759 .6761 6 . 1024EX .7961 .1799 74*3 .1651 .7170
1 1221 1 5239 1.7377 1 4637 1 4726
.9425 1 0113 1 3222 1 2207 1 5967 1.3330 1 2231 1.3529
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BRAIN WEIGHT RATIOS
I WEEK SACRIFICE
HWI 6329-100 PRINTED. ll-OCT-91
PAGE: 6
TABLE INCLUDES: SEX-ALL;GROUP-ALL.WEEKS-ALL DEATH-2;SUBSET-ALL
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF . tESTIS. TE1 - RT. TESTIS.
SO - ACCESS/SEX ORG
SEX DOSE ANIMAL TERMINAL .................................................................................
GROUP NUMBER BODY WT (9 )
BR
LI
LU
TEO TEI SO
M a C67766 M a C6776
392.4 437.3
1.0000 1.0000
6.3276 6.5671
.7412 .6572
.6127 .6826
.7973 .8518
1.4575 1.3165
NUM8ER IN GROUP: MEAN:
STANDARO DEV:
15 449.3
24.9
15 1.0000 .0000
IS 1.1176 1.1411
15 .7465 05S6
IS .7831 .0872
14 .7123 .0727
15 1.3864 .2390
r>
O
n
o
cn
r0U\0>1
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORQAN-TO-BRAIN WEIGHT RATIOS
14 WEEK SACRIFICE
HWI 6329-100 PRINTED: U-OCT-91
PAGE: 1
TABLE INCLUDES: SEX-ALL GROUP-ALL:WEEKS-ALL DEATH-T;SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 1 C674S4 M 1 C674S9 M 1 C67460 M 1 C67462 M 1 C67470 M 1 C67473 M 1 C67475 M 1 C674I2 M 1 C67485 M 1 C67487 M 1 C67488 M 1 C67499 M 1 C67S01 M 1 C67504 M 1 C67505 NUMBER IN GROUP :
MEAN: STANDARD DEV:
TERMINAL BODY WT (g)
569 7 495.1 531 9 596.7 519 7 610 5 567.4 511 1 595.6 523 4 621 2 577 0 511 0 600.3 548.1
15 558 7
41.1
: BR - BRAIN, LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - L F . TESTIS. TE1 - RT. TESTIS. SO - ACCESS/SEX ORG
BR
1 0000 1 0000 1.0000 1 0000 1 0000 1 0000 1 0000 1 0000 1.0000 1 0000 1 0000 l 0000 1.0000 1.0000 1 0000
15 1.0000 .0000
LI 9 5312 7 3415 8 6932 8 7330 9 8734 12.0263 8 7857 7 5861 9 5207 7 3411 9.8076 8 3947 8 6686 9.8928 9.2948 15 9 0327 1.2007
LU .7545 .7151 .6946 .7076 .7433 .7850 .7702 7720 .8960 .6611 .7746 .7470 .7371 .8631 7142 15 7557 .0609
TEO .7930 .8440 .6716 .8458 .8860 .8728 .8186 .8847 .8787 .7205 .7221 .8238 .7024 .8524 .7624 15 8053 .0723
TEI .8069 .8516 .6980 8281 .8767 .8951 .8254 .8842 .8630 .7044 .7088 .8180 .7003 8359 .7692 15 8044 .0708
SO 1.6236 1.3598 1.7169 2 0231 1 6576 1 7687 1 5347 1 4872 1 3427 1.7733 1.7421 l 7514 1 5127 1 2255 1 5765 15 1.6064
2047
M 2 C7507 M 2 C6751I M 2 C67519 M 2 C67521 M 2 C67S23 M 2 C67S26
527.0 467.2 515.4 557.6 613 6 513 2
*ft CONTINUED ON NEXT PAGE **
1.0000 1.0000 1 0000 1 0000 1.0000 1.0000
5 4209 6 9771 7 9051 7.7199 9 5627 7.1660
.4845 .6861 .7587 .7872 .8233 .6960
6229 8121 .5500 .7200 .8693 7868
6096 8497 .8645 7463 8527 7998
9907 1 5652 1 4425 1 5880 1 4722 1 3441
ro 0<n0
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BRAIN WEIGHT RATIOS
14 WEEK SACRIFICE
HWI 6329-100 PRINTED ll-OCT-91
PAGE: 2
TABLE INCLUDES: SEX*ALL;GROUP*ALL;WEEKS*ALL DEATH* T;SUBSET ALL
SEX OOSE ANIMAL GROUP NUMBER
M 2 C67533 M 2 C67535 M 2 C67536 M 2 C67S41 M 2 C67549 M 2 C675S1 M 2 C67552 M 2 C67553 M 2 C67SS6 NUMBER IN GROUP:
MEAN: STANDARD DEV:
TERMINAL BODY WT (9 )
MISSING 549 3 570 3 562 I 609.5 513.4 610 2 560.6 532 3 14 555.1 42 0
ORGAN
. gg _ BRAIN. LI ABBREVIATION! TEO - LF. TESTIS.
LIVER, TEI -
LU RT.
- LUNG TESTIS.
BR LI LU TEO TE1
1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 14 1.0000
.0000
1.0675 8 5271 7 7119 10.3611 7.4736 11.1041 8.4797 7.4836 14 8 1901 1.5593
.8050 .7675 .8666 .7686 .6772 .5793 :8351 .6277 14 .7259 .1075
.9074 .8496 .7442 .8065 .7709 1 .0297 .8373 .8742 14 .7844 .1209
.9075 8725 .7328 .8063 7848 1.2792 8371 .6770 14 .8300 1528
SO - ACCESS/SEX ORG
SO
1.6797 1 3890 1.7731 1.7570 1 8803 1 8850 1.6965 1.6490 14 1 5795
.2402
M 3 C67S63 M 3 C67564 M 3 C67571 M 3 C67S96 M 3 C6759* M 3 C67600 M 3 C67603 M 3 C67604 M 3 C6760S M 3 C67607 M 3 C6760I M 3 C67610
631 7 569.9 491 6 511 5 534 3 595 1 609.4 556.1 573.2 527.1 500.4 546.1
** CONTINUED ON NEXT PAGE **
1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1 0000 1.0000 1.0000 1.0000 1.0000
12.4878 9 4027 8 1736 9 0336
10 8400 10.9414 10.2760
9.4008 9 8969 8 7105 8 2394 7.6610
.8697 .7378 .6699 .6284 .7758 .7814 .7942 .8076 .7388 .4547 .7332 .7167
.8414 .8573 .9223 .7434 8021 .7885 .7759 .8977 .7894 .6916 .8851 .7201
.7990 8103 .8754 .7307 .8037 .7796 .7770 .8873 7962 .8875 .8454 .7215
1.8077 1 8533 2 0227 2 0389 1 3870 1 5813 1.4861 1 6216 1 4542 1 2363 1 5308 1 6612
,
% %
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BRAIN WEIGHT RATIOS
14 WEEK SACRIFICE
HWI 6329-100 PRINTED ll-OCT-91
PAGE 3
TABLE INCLUDES: SEX*ALL;GROUP*ALL WEEKS-ALL DEATH*T;SUBSETALL
SEX DOSE ANIMAL GROUP NUMBER
M 3 C67611 M 3 C$7613 M 3 C6761S NUMBER IN GROUP :
MEAN: STANDARD DEV:
TERMINAL BOOT WT (gj
529.2 513 2 529.4
15 552 7
40.7
: BR - BRAIN LI LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF. tESTIS, TEI - RT. TESTIS. SO - ACCESS/SEX ORO
BR 1.0000 1.0000 1.0000 IS 1.0000
.0000
LI 8 6475 9 6948 7.7666 15 9 4115 1.3310
LU .6503 .7946 .7427 15 .7264 .0982
TEO .7511 .7491 .8710 15 .8191 .0655
TE1 .7837 .7568 .8568 15 .6074 .0532
SO 1 8122 1.4097 1.5164 15 1.6281
2354
M 4 C67616 M 4 C67618 M 4 C67621 M 4 C67623 M 4 C67624 M 4 C87635 M 4 C67641 M 4 C67643 M 4 C6764S M 4 C67650 M 4 C676S2 M 4 C676S3 M 4 C676SI
586.9 596.6 607.0 470.7 536.7 544.9 545.4 455 6 621 6 556 3 506 3 592 1 444.1
** CONTINUED ON NEXT PAGE **
1 0000 1 0000 1 0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000
12 0257 10.5392 11.3484
8.5155 12.5377
9.8416 12 7716
8 4527 10 9111 13 2312 10 0803 13 7571 9.0204
.7705 .7554 .7918 7509 7020 .7607 .6671 .8331 .7803 .8115 7420 8665 .7190
.9197 .8137 .7514 .7955 .8092 .9129 .8161 .8245 .8934 .8257 .8864 .8994 .8000
.8865 .7975 .7386 .7892 .6318 .9506 .8632 8359 9115 .7984 .8688 .8890 7864
1.7173 1.8240 1.1306 1.7909 1 6046 1 4765 1 3143 1 8094 1 4298 1 6177 1 9535 1 6122 1 5438
50200
N0>0 00
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BRAIN WEIGHT RATIOS
14 WEEK SACRIFICE
HWI 6329-100 PRINTED: U-OCT-91
PAGE: 4
TABLE INCLUDES. SEX-ALL;GROUP-ALL;WEEKS-ALL DEATH- T;SUBSET -ALL
SEX DOSE ANIMAL GROUP NUMBER
M 4 C67668 M 4 C67669 NUMBER IN GROUP :
MEAN: STANDARD DEV:
7ERMINAL BODY WT (9 )
484.9 523.5
15 538 2
56.8
ORGAN
: BR - BRAIN. LI ABBREVIATION: TEO - LF. tESTIS.
LIVER. TEI -
LU RT.
- LUNG TESTIS.
BR 1.0000 1.0000 15 1.0000
.0000
LI 7.0144 11.6695 15 10.7811 1.9614
LU .7497 .7673 15 .7632 .0499
TEO .8327 .8647 15 .8430 .0498
TEI .8325 .8627 15 .8428 .0555
SO - ACCESS/SEX ORQ
SO 1 4290 1.7631 15 1.6014
.2198
M 5 C67671
550.6
M 5 C67672
459.5
M 5 C67673
501.8
M 5 C67677
532 1
M 5 C67679
437.4
M 5 C67686 MISSING
M S C67688
412.5
M 5 C67691
405.9
M S C67695
385.9
M 5 C67697
481.7
M 5 C67700
558 6
M 5 C67712
583.8
M 5 C67714
415.5
** CONTINUED ON NEXT PAGE **
1.0000 1.0000 1 0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1 0000 1 0000 1.0000
12.9969 9.3841 9.9924
10.8141 13.8469 11 5994
9 8559 10.2835 14.3865 16 5701 15.1468 13.2834
.7714 .6564 .6434 .6758 .7557 .6352 .6516 6310 .6943 .9641 .7636 .6925
.8844 .7849 .7419 .7627 .9091 .6941 .7539 .8587 .8589 .9965 .8522 .7710
.8850 .7838 .7311 .7673 .8676 .7307 .7067 8141 .8618 9532 .8453 .8122
1.5746 1.5584 1.4480 1.2231 1.5016 1 0738 1 4476 1 4389 1 9537 2 0213 1 8720 1 5176
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BRAIN WEIGHT RATIOS
14 WEEK SACRIFICE
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: S
TABLE INCLUDES: SEX-ALL.GROUP-ALL;WEEKS-ALL DEATH-T;SUBSET-ALL
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF . TESTIS. TE1 - RT. TESTIS.
SO - ACCESS/SEX ORG
SEX DOSE ANIMAL TERMINAL
GROUP NUMBER BOOT WT (9 )
BR
LI
LU
TEO TEI SO
M 5 C67716 M 5 C67720
464.7 65*. 1
1.0000 1.0000
9.8764 1*7327
.7242 .7753
.7651 .9232
.740* .9167
1.2743 2.2707
NUMBER IN GROUP: MEAN:
STANOARD DEV:
14 4*9 1
79.0
14 1.0000 .0000
14 12.6121
2 .*123
14 .7096 .0816
14 .1255 .0(49
14 .1154 .0759
14 1 5(40 .3327
H 6 C7730 M 6 C67732 M 6 C67736 M 6 C6773* M 6 C67740 M 6 C67744 M 6 C67746 M 6 C67747 M 6 C6774S M 6 C67749 M 6 C67754 M 6 C67755 M 6 C67756
490. 1 532.2 516.5 523 1 466.7 503.7 474 3 536 4 503.4 495.6 546 3 473 7 490.0
** CONTINUED ON NEXT PAGE **
1 0000 1 0000 1.0000 1 0000 1.0000 1 0000 1 0000 1.0000 l .0000 1.0000 1 0000 1 0000 1.0000
1 0202 6.9991 7.5015 7 9*71 7 2645 7 4923 6.7764 9 7794 7 5027 7.6214 *3416 6 4*00 * 0551
.7(14 .7054 .6956 .7606 .6520 .7125 .1160 .7012 .7623 .7501 .7936 .7979 .7416
*217 .9197 .134* .9115 .7909 .7669 .7510 .7547 .7972 .7662 .1250 .7994 .7623
.1220 .1*95 .1211 .*100 .7109 .7*53
7460 .7213 (159 .7377 .1297 .1067 .7664
1.6513 1.0050 1.5311 1 5014 1.4745 2 1134 1.6223 1.6555 1 7451 1 3554 2 0200 1 0504 1.4132
sozo-o
r*ooo
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BRAIN WEIGHT RATIOS
22 WEEK SACRIFICE
HWI 6329-100 PRINTED U-OCT-91
PAGE 1
TABLE INCLUDES: SEX-ALL;GROUP-ALL WEEKS-ALL DEATH-U:SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 1 C674S2 M 1 C67453 M 1 C67456 M 1 C67471 M 1 C67479 M 1 C674I3 M 1 C67490 M 1 C67493 M 1 C67496 M 1 C67497 NUMBER IN GROUP :
MEAN: STANOARD DEV:
TERMINAL BOOT WT (g)
564 9 666 3 564.9 653.1 469.7 615.4 610 6 510.4 507.2 597.7
10 576 1
61.6
: BR - BRAIN, LI - LIVER, LU - LUNG ORGAN ABBREVIATION: TEO - L F . TESTIS. TE1 - RT. TESTIS. SO - ACCESS/SEX ORG
BR
1.0000 1 0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000
10 1.0000 .0000
LI 8 2525 11.0585 8.1040 10.4023 6 9171 8 9113 9.8077 7.6069 7 7233 8.4933 10 8 7277 1 3187
LU .7390 .8677 .7428 .7307 .7157 .7057 .8092 .%7402 .7363 .7026 10 .7490 .0512
TEO .7520 .9248 .6576 .7910 .7375 .7938 .8809 .8364 .8499 .7279 10 .7952 .0799
TEI .7993 .9776 .6574 .8082 7613 .7836 .9235 .8664 .9018 .7438 10 .8243 .0966
SO 1 9802 1 8773 1 6624 1 7414 1 1949 1 6920 1 9112 1 4312 1.5839 1.7595 10 1 6634
.2255
M 2 C67508 M 2 C67513 M 2 C67S16 M 2 C67517 M 2 C67520 M 2 C67528 M C67S34 M 2 C67538
563 4 680.3 678.8 618 8 551 1 567 8 610.9 692.6
* CONTINUED ON NEXT PAGE *
1 0000 1.0000 1.0000 1.0000 1 0000 1.0000 1.0000 1.0000
8.6761 9 3378 8.6478 8 3283 6.8399 7.8974 7 9294 8.8109
.8043 .8302 8521 .7198 .7231 .6988 .8073 8527
.7094 .7197 .8223 .8844 7526 7858 8728 8079
7493 .7467 8022 .9530 .7449 .7740 .8586 .7508
1 7501 1 7102 1.4364 1 8804 1 8510 1 6153 1 6546 1 6872
tn
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BRAIN WEIGHT RATIOS
22 WEEK SACRIFICE
HWI 6329-100 PRINTED 1l-OCT-91
PAGE: 2
TABLE INCLUDES: SEX-ALLGROUP-ALL;WEEKS-ALL DEATH-U;SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 2 C67S43 M 2 C67S4I NUMBER IN GROUP:
MEAN: STANDARD DEV:
TERMINAL BOOT WT (g)
546 2 560.7
10 607 1
Sl.l
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - LF . TESTIS, TE1 - RT. TESTIS. SO - ACCESS/SEX ORG
BR 1 0000 1.0000 10 1.0000
.0000
LI 7 .6990 1.0*03 10 . 2047
.7112
LU .7(20 .6107 10 .7751 .0645
TEO .6792 .7*07 10 .7(15 .0610
TEI .6140 .7666 10 .730 .0746
SO 1 0133 1.6026 10 1 6271
2294
M 3 C67561 M 3 C67567 M 3 C67572 M 3 C67573 M 3 C67575 M 3 C67579 M 3 C675II M 3 C67SI9 M 3 C67S93 M 3 C67609 NUMBER IN GROUP:
MEAN: STANDARD DEV.
612 640.3 553 3 526.7 729 2 517.0 571 7 630.1 709.5 730 9
10 629 2
73 4
1 .0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000
10 1.0000 .0000
4(19 11*0 2713 6.512 9.7102 571 1423 9.9660 9.9648 1.0011 10 S 5ISI 1.0599
.7111 .7154
.7972
.7333 .71(1 .7597 .7227 .9773 .7575 .8732
10 .7626 .0S35
.5I9 .7655 .7410 .7957 .193 .193 .6(14 .9252 .9076 .7776 10 .7903 .1042
.7554 .7791 .7034 .7934 (916 .211 .7166 .9693 .1975 .1270 10 16 0*52
1 197 1.4104 1.4141 1.7074 1.5237 1 746 1 6321 1 6536 1.79(2 1 4351 10 1.6320
.1649
M 4 C67622 M 4 C67626 M 4 C67629
563.6 560.2 666.5
** CONTINUED ON NEXT PAGE *
1 0000 1.0000 1.0000
10 116 9 0171 9.6974
.7230 .7919 .7962
191 .9096 .9421
.9503 .9113 (432
1 1401 2 OSO 2.0135
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BRA1N WEIGHT RATIOS
22 WEEK SACRIFICE
HWI 6329-100 PRINTED. ll-OCT-91
PAGE: 3
TABLE INCLUDES. SEX-ALL.GROUP-ALL;WEEKS-ALL DEATH-U;SUBSET-ALL
SEX DOSE ANIMAL GROUP NUMBER
M 4 C67637 M 4 C67649 M 4 C67651 M 4 C67660 M 4 C67664 M 4 C67666 M 4 C67670 NUMBER IN GROUP :
MEAN: STANDARD DEV.
TERMINAL BODY WT (g)
529.9 601 5 614.9 557 9 694 3 609.1 620 5
10 601 1
51.2
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - L F . TESTIS, TE1 - RT. TESTIS. SO - ACCESS/SEX ORG
BR
1.0000 1.0000 1.0000 1.0000 1.0000 1 0000 1.0000
10 1 0000 .0000
LI 10.5560
8.1761 9 7034 8.6908 9.5272 8.7206 10.8655 10 9 5071
.8621
LU .7881 .7090 .7612 .7264 .9205 .7366 .8100 10 .7763 .0618
TEO .7338 .5725 .8417 .7302 .7653 .8621 .8803 10 .7828 .1097
TEI .7492 .9040 .8285 .7495 .7708 .6546 .8605 10 .8229 .0917
SO 1.5604 1.9091 1.5208 1.6015 1.9984 1 8034 1.8297 10 1 8158
.1973
M S C67674 M 5 C67676 M S C67676 M 5 C676S3 M S C676I4 M 5 C67694 M 5 C67701 M 5 C67704
655.4 399 4 552 5 593 0 490.9 595.7 541.8 597.4
A CONTINUED ON NEXT PAGE **
1 0000 1.0000 1.0000 1.0000 1.0000 1 0000 1.0000 1.0000
9.7543 7.1931 9.441S 8 1368 6 8434 8 7881 9.4068 9.9661
.7625 .7285 .6829 .7183 .7021 .7788 .8273 .7622
.8862 .7865 .8366 .7286 .7991 .8079 .8579 .8032
.8604 .7589 8332 .7332 .8275 .7586 .8536 .8358
1.7649 2 0640 1 7461 1 6980 1 1962 1 8085 2 3752 1.5438
GO2 0 5 $
M wVO
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ORGAN-TO-BRAIN WEIGHT RATIOS
22 WEEK SACRIFICE
HWI 6329-100 PRINTED: 11-OCT-91
PAGE. 4
TABLE INCLUDES: SEX-ALL;GROUP-ALL;WEEKS-ALL DEATH-U;SUBSET-ALL
: BR - BRAIN. LI - LIVER. LU - LUNG ORGAN ABBREVIATION: TEO - L F . TESTIS. TE1 - RT. TESTIS.
SO - ACCESS/SEX ORG
SEX DOSE ANIMAL TERMINAL .................................................................................
GROUP NUMBER BODY WT 19 )
BR
LI
LU
TEO TE1 SO
M 5 C67706 M 5 C67723
572.9 561.3
1.0000 1.0000
9 1796 7.6910
.7164 .7774
.7631 .9531
.7692 .9097
1.5713 1.5326
NUMBER IN GROUP: MEAN:
STANDARD DEV:
10 556.0
69.6
10 1.0000 .0000
10 6.7300 1.1471
10 .7456 .0434
10 .6242 .0827
10 .6140 .0563
10 1 7299 .3196
j
^ozo
Nl>
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 16-OCT-91
PAGE: 1
ANIMAL NUMBER: C674S1
SEX. MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 447.6 GRAMS
DATE AND TIME OF NECROPSY: 01/2S/91 9:11
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU| LF TESTIS (TEO) RT. TESTIS (TE1| ACCESS/SEX ORG (SO)
2.2017 17.2631
1.7496 1.7109 1.7540 2.6091
.4919 X 3.1570 X
.3909 X .3979 X .3919 X .5129 X
1.0000 7.1411
.7947 .1069 .7967 1.1150
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC| GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CGI. LF . TESTIS (TEO|. LIVER (LI|, LUNG (LU). PROSTATE (PR|. SEMINAL VESICLE (SV|. URETHRA (UR|
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 18-OCT-91
PAGE: 2
ANIMAL NUMBER: C674S2
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS. SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/17/91
STUDY DAY OF DEATH: 149
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 564 9 GRAMS
DATE AND TIME OF NECROPSY: 05/17/91 1:21
PROSECTOR: DEBBIE PIRKEL
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DENNIS HOFFMAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (8R ) LIVER (LI) LUNG (LU) LF. TESTIS (TEO ) RT. TESTIS (TE1 I ACCESS/SEX ORG (SO)
2.1155 11.0351
1.6150 1 6436 1.7469 4.3276
.3869 X 3.1927 X
.2159 X .2910 X .3092 X .7661 X
1 0000 8.2S25
.7390 .7520 .7993 1.9102
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT.TAKEN
ORGAN NAME
* * PA T H 0 L 0 G Y O B S E R V A T I 0 N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC GROS!S: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR), COAGULATING OLD |CG). L F . TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
r>
? ) fUO\)i>
O
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE 3
ANIMAL NUMBER: C674S3
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/16/91
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 22
TERMINAL BOOY WEIGHT: 666.3 GRAMS
DATE AND TIME OF NECROPSY: 05/16/91 7:27
PROSECTOR: DEBBIE PIRKEL
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: OR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS ITE01 RT. TESTIS ITE 11 ACCESS/SEX ORG (SO)
2.1363 23.8464
1.6553 1.9776 2 0904 3.5666
.3209 X 3.5469 X
.2764 X .2966 X .3137 X .5363 X
1.0000 11.0565
.6677 .9246 9776 1 6773
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT. TAKEN
ORGAN NAME
* P A T H O L O G Y KEYWORDS. SEVERITY, DISTRIBUTION
O B S E R V A T I O N S GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI GROSS: -ALL TISSUES/ORQANS NORMAL
LIVER fLX| . . . . MICRO: -s l i g h t ; FOCAL
NECROSIS.COAGULATIVE
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CO). L F . TESTIS (TED). LUNG (LU). PROSTATE (PR), SEMINAL VESICLE |SV|, URETHRA (UR)
oo
N
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 4
ANIMAL NUMBER: C67454
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 569.7 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 9:22
PROSECTOR: STEVE VAN ADESTINE
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS 1
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2.1122 20 7969
1.6464 1.7305 1.7609 3.5431
.3630 X 3.6509 X
.2690 X .3036 X .3091 X .6219 X
1.0000 9.5312
.7545 .7930 .6069 1.6236
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT, TAKEN
ORGAN NAME
** PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
GENERAL COMMENT (G C ) ......................... GROSS: -A\L TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING GLD ICG). L F . TESTIS (TED). LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
90209
NU>
00
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOQY DATA
HWI 6329-100 PRINTED: 18-OCT-91
PAGE: 5
ANIMAL NUMBER: C67455
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDV DAY OF DEATH: 57
STUDY WEEK OF DEATH: 9
TERMINAL BODY WEIGHT: 463.7 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 7:45
PROSECTOR: KEVIN BILLINGS
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR) LIVER ILI) LUNG (LU| LF. TESTIS (TEO1 RT. TESTIS (TE1 ACCESS/SEX ()RG (SO)
1.9797 IS.5440
1 6555 1.5477 1.5114 2.7615
.4269 X 3.3522 X
.3570 X .3336 X .3425 X .5955 X
1.0000 7.6517
.8362 .7618 .8023 1.3949
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O Q KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI1 .................................... MICRO. -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR), COAGULATING OLD (CG). LF . TESTIS (TEO|. LUNG (LU). PROSTATE (PR| SEMINAL VESICLE (SV|. URETHRA (UR)
(?)
K rttooo
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE. 6
ANIMAL NUMBER: C674S6
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/16/91
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 564.9 GRAMS
DATE AND TIME OF NECROPSY: 05/16/91 7:41
PROSECTOR: DEBBIE PIRKEL
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BRI LIVER (LI) LUNG (LU) LF TESTIS (TEO| RT. TESTIS (TElj ACCESS/SEX ORG (SO)
2.1450 17.3131
1.5932 1.4105 1 4101 3.5659
.3797 X 3.0772 X
.2920 X .2497 X .2496 X .6312 X
1.0000 9.1040
.7429 .6576 .6574 1.6624
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * * P A T H O L 04 Y O B S E R V A T I O N S
KEYWORDS, SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD ICG). L F . TESTIS (TEO), LIVER |L1), LUNG (LU), PROSTATE (PR). SEMINAL VESICLE |SV|. URETHRA |Uli|
o
Q
?) e>
Ooo)
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 16-OCT-91
PAGE: 7
ANIMAL NUMBER: C67457
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: fl
TERMINAL BOOY WEIGHT: 375.7 GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 l:3<
PROSECTOR: KEVIN BILLINGS
RECORDER: VAL OUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TE01 RT TESTIS It e i ) ACCESS/SEX ()RG (S0|
2 0693 15.3097
1 4270 1.5370 1 5010 2.6754
.5506 X 4.0747 X
.3796 X .4091 X .4014 X .7121 X
1.0000 7.3910
.6196 .7426 .7267 1.2929
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS *** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BRI. COAGULATING GLD (CG). LF . TESTIS (TEO). LIVER (LI). LUNG (LU|, PROSTATE |PR), SEMINAL VESICLE (SV). URETHRA (UR|
o
Uol
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED. 16-OCT-91
PAGE: I
ANIMAL NUMBER: C674S9
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDY DAY OF DEATH: S7
STUDY WEEK OF DEATH: 9
TERMINAL BOOY WEIGHT: 450.9 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 9:32
PROSECTOR: RUTH SCHMITZ
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT 1GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR 1 LIVER (LI ! LUNG (LU) LF. TESTIS 1TEOI RT. TESTIS 1TEI j ACCESS/SEX ORO (SO)
2 0532 16.0617
1.5344 1.6389 1.5900 2.5526
.4554 X 3.5621 X
.3403 X .3830 X .3526 X .5661 X
1.0000 7.6226
.7473 .7972 .7744 1.2432
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL C0W4ENT IGCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). L F . TESTIS (TEO), LIVER (LI), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
ao o0
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 19-OCT-91
PAGE: 9
ANIMAL NUMBER: C67459
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF DEATH: 97
STUOY WEEK OF DEATH: 14
TERMINAL BOOY WEIGHT: 495.9 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 9:10
PROSECTOR: DEBBIE PIRKEL
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT 1GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BRI LIVER (LI) LUNG (LU) IF. TESTIS (TEOI RT. TESTIS (TEl| ACCESS/SEX ORG (SO)
2.1392 15.7049
1.5299 1.9054 1 9219 2.9099
.4315 X 3.1678 X
.3096 X .3641 X .3674 X .5967 X
1.0000 7.3415
.7151 .9440 .9516 1.3599
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
*** PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI ..................................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
GENERAL INFORMATION (XX) ..........................................................................................................
GROSS:
NECROPSY NOTE: >MASS (VENTRAL HIND RIGHT) NOTED IN CLINICAL OBSERVATIONS WAS NOT
FOUND AT NECROPSY
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). LF . TESTIS (TEO). LIVER (LI). LUNG (LUI. PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
0200
u ou (ft
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 10
ANIMAL NUMBER C67460
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/2S/91
STUDY DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 531.9 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 7:31
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE '
PATHOLOGIST: OR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT 1GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI| LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2.4141 20.9163
1.6761 1 6212 1.6150 4.1441
.4539 X 3.9455 X
.3152 X .3041 X .3166 X .7792 X
1.0000 6.6932
.6946 .6716 .6960 1.7169
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
BSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI| ................................... MICRO: -MINIMAL, FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG), L F . TESTIS (TEO). LUNG (LU). PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA |UR|
oo oN
uot
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED lt-OCT-91
PAGE: 11
ANIMAL NUMBER. C67481
SEX: MALE
DOSE GROUP. 1
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUDY DAY OF DEATH: 35
STUDY WEEK OF DEATH: 5
TERMINAL BOOY WEIGHT: 409.0 GRAMS
DATE AND TIME OF flECROPSY: 01/23/91 (:34
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER. GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS TE1 ACCESS/SEX ORG (SO)
2.1204 16.3219
1.5015 1.57(5 1.6495 2.(661
.5114 X 3.9907 X
.3671 X .3(59 X .4033 X .7009 X
1.0000 7.6976
.70(1 .7444 .7779 1.3517
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOG KEYWORDS. SEVERITY. DISTRIBUTION
0 BSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER ill| .................................... MICRO: -SLIGHT. FOCAL
-INFILTRATES,MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). LF . TESTIS (TEO), LUNG |LU|. PROSTATE (PR|. SEMINAL VESICLE (SV). URETHRA (UR|
Qn
N OoiJn O
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIHAL PATHOLOGY DATA
HWI 6329-100 PRINTED: I8-OCT-91
PAGE: 12
ANIMAL NUMBER: C67462
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
OATE OF OEATH: 03/25/91
STUDY DAY OF DEATH. 96
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 596.7 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 9:50
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. KIZ2IEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
0RGAN S TA TU S
BRAIN 1BR ) LIVER (LI) LUNG (LU | LF. TESTIS (TEO) RT. TESTIS 1TEL I ACCESS/SEX OAO (SO)
2.1057 11.3191
1.4199 1.7111 1.7436 4.2601
ORGAN NAME
* P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
.3529 X 3.0111 X
.2497 X .2965 X .2922 X .7139 X
1.0000 8.7330
.7076 .8458 .8281 2.0231
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
O B S E R V A T I 0 NS
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI GROSS : -ALL TISSUES/ORGANS NORMAL
LIVER (LI) . . . . MICRO : -SLIGHT, FOCAL
-INFILTRATES,MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING1 GLO (CG), LF. TESTIS (TEO). LUNG (LU). PROSTATE (PR) . SEMINAL VESICLE (SV). URETHRA (UR|
fOZGO
wo
<71
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED. ll-OCT-91
PAGE: 13
ANIMAL NUMBER: C67463
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDY DAY OF DEATH: 55
STUDY WEEK OF DEATH: t
TERMINAL BODY WEIGHT. 462 6 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 9:30
PROSECTOR: KEVIN BILLINGS
RECOROER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: OR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER 1LI) LUNG (LU1 LF. TESTIS (TEO]I RT. TESTIS (TCI ACCESS/SEX ORQ ISO)
2.2372 16.5945
1.7612 1.6595 1 7104 3.SSI0
.4636 X 3.4316 X
.3664 X .3439 X .3544 X .7373 X
1.0000 7.4175
.7904 .7416 .7645 1.5904
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I OHS ' * '
1
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR I. COAGULATING OLD (CG(. L F . TESTIS fTEO). LIVER (LI), LUNG |LU). PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UA)
.0200
uoN>l
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED. lt-OCT-91
PAGE: 14
ANIMAL NUMBER: C67464
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/01
STUDY DAY OF DEATH: 37
STUOV WEEK Of DEATH: 6
TERMINAL BOOY WEIGHT: 425.B GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 1:01
PROSECTOR: NANCY DIEDRICH
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN 1BR) LIVER (LI) LONG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2.0479 17.2570
1 5111 1 .812 1.6505 2.3400
.4101 X 4.0519 X
.3564 X .3716 X .3675 X .5494 X
1.0000 6.4267
.7413 .7674 .6059 1.1426
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ................................... MICRO: -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR). COAGULATING GLD (CO). L F . TESTIS |TE0). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE fSVJ. URETHRA (UR)
w
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED. 16-OCT-91
PAGE: 15
ANIMAL NUMBER: C67465
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH: 56
STUDY WEEK OF DEATH: I
TERMINAL BOOY WEIGHT: 422.1 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 9:04
PROSECTOR: DENNIS HOFFMAN
RECOROER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS ITEOI RT. TESTIS ]TE1 ACCESS/SEX <)RG (SO)
2.1366 15.6909
1.4707 1.6221 1.7656 2.5464
.5062 X 3.7173 X
.3464 X .4317 X .4163 X .6037 X
1.0000 7.3439
.6663 .6526 .6264 1.1927
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G V O B S E R V A T I O N S **
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC I ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBRK COAGULATING OLD (CG), L F . TESTIS |TE0|. LIVER (LI). LUNG (LU). PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UA)
frLOZOD
oto
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 19-OCT-91
PAGE. 16
ANIMAL NUMBER: C67466
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUOV DAY OF DEATH: 56
STUDY WEEK OF DEATH. <
TERMINAL BOOY WEIGHT. 490.3 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 1:05
PROSECTOR: JULIE A. LARSEN
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER. JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (Y)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT TESTIS (TE1) ACCESS/SEX ORG (SO)
2 0132 19 3221
1 4311 1 5414 1 6171 3 1714
4249 X 3.9410 Y
.2919 Y .3151 Y .3300 Y .6493 Y
1.0000 9.2755
.6170 .7433 .7766 1.5257
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). LF . TESTIS (TEO), LIVER (LI). LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
w 3 Mo
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1S-0CT-91
PAGE: 17
ANIMAL NUMBER. C67467
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 420 5 GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 9:40
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TElj ACCESS/SEX ORG (SO)
2.1977 14.6161
1.6460 1 5141 1 5651 2 6690
.5226 X 3.4925 X
.3914 X .3767 X .3722 X .6823 X
1.0000 6.6625
.7490 .7208 .7122 1.3055
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC BINDINGS
GENERAL COMMENT (GC| ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CO). L F . TESTIS (TEO). LIVER (LI), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: II
ANIMAL NUMBER: C6746I
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUOY DAY OF DEATH: 35
STUDY WEEK OF DEATH: 5
TERMINAL ODY WEIGHT: 391.0 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 1:43
PROSECTOR: NANCY DICDRICH
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR11 LIVER |LI]1 LUNG (LU) LF. TESTIS (T0 | RT. TESTIS 1TE11 ACCESS/SEX ORG ISO)
2.0211 14 9001
1.5145 1.7321 1.1014 2.5129
.5097 X 3.7439 X
.3911 X .4352 X .4544 X .6490 X
1 0000 7.3446
.7110 .1531 .1914 1.2731
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L 00 Y O B S E R V A T I O N S *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT |GC} ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI| ................................... MICRO: -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD ICG). L F . TESTIS |TEO). LUNG |LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
C0Z077
fs>
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 19
ANIMAL NUMBER: C67469
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. SECONO INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH: 56
STUDY WEEK OF DEATH: I
TERMINAL BOOY WEIGHT: 494 0 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 9:17
PROSECTOR: RUTH SCHMITZ
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT 1GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) IF TESTIS (TEO) RT. TESTIS TE1 ACCESS/SEX ORO (SO)
2 0755 21 3445
1.5966 1 6613 1 7176 3 0237
.4201 X 4.3207 X
.3236 X .3363 X .3477 X .6121 X
1.0000 10.2840
.7702 .1004 .1276 1.4560
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT JGCI .......................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER ILI) ..................................................................................
MICRO: -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BRI. COAGULATING OLD (CG), L F . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE |SV). URETHRA (UR I
0
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HUI 6329-100 PRINTED: 18-OCT-91
PAGE: 20
ANIMAL NUMBER. C674T0
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL ODY WEIGHT: 519.7 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 i:55
PROSECTOR: STEVE VAN AOESTINE
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE11 ACCESS/SEX ORG (SO)
2.0425 20.1664
1 5111 1 1097 1.7907 3.3856
.3930 X 3.8804 X
.2921 X .3482 X .3446 X .6515 X
1.0000 9.8734
.7433 .8860 .8767 1 6576
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * * P A T H O L 0.0 Y O B S E R V A T I O N S *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT jGC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR |, COAGULATING OLD (CO I. L F . TESTIS (TEO|, LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
o o
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE. 21
ANIMAL NUMBER. C67471
SEX. MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, FIRST POST-RECOV SAC
DATE OF DEATH: 05/17/91
STUDY DAY OF DEATH: 149
STUDY WEEK OF DEATH: 22
TERMINAL BOOY WEIGHT: 653.1 GRAMS
DATE AND TIME OF NECROPSY: 05^17/91 6:31
PROSECTOR: RUTH SCHMITZ
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILAB
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DENNIS HOFFMAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT TESTIS (TE1 ACCESS/SEX <)RG (SO)
2 2174 23.0661
1.0203 1.7540 1 7921 3 0614
.3392 X 3.52*0 X
.2479 X .2603 X .2741 X .5906 X
1.0000 10.4023
.7307 .7910 .0002 1.7414
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
*** PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COFMENT GROs!: -ALL TISSUES/ORGANS NORMAL
PROSTATE IPR I MICRO: -SLIGHT! FOCAL
-INFLAMMATION. CHRONIC ACTIVE
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). LF. TESTIS (TEO). LIVER (LI). LUNG |LU|. SEMINAL VESICLE fSV), URETHRA |UR|
o
oo
*0
O*c--Jn
(JO
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 22
ANIMAL NUMBER: C67472
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH: 56
STUDY WEEK OF DEATH: t
TERMINAL BODY WEIGHT: 516 * GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 7:50
PROSECTOR: JULIE A. LARSEN
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: OR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT 1GRAMS 1
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORG A N S TA IU S
BRAIN (BR I LIVER 1 LI J LUNG (LU) LF. TESTIS (TEOI RT. TESTIS TEI ACCESS/SEX ORG (SO)
2 0216 21.05(0
1 5394 1 9755 1.9155 3.3550
.3912 X 4.074.7 X
.2979 X .3123 X .3(42 X .6492 X
1 0000 10.4165
.7615 .9772 .9(21 1.6596
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG), L F . TESTIS (TEG). LIVER (LI), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV), URETHRA (UR|
G020S
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 19-OCT-91
PAGE: 23
ANIMAL NUMBER: C67473
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/25/91
STUDY DAY OF DEATH: 98
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT. 610.5 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 1:02
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. K1Z2IEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS 1
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS |TEO) RT. TESTIS (TE11 ACCESS/SEX ORG (SO)
1 9927 23 9941
1 5642 1 7392 1 7136 3 5245
.3264 X 3.9254 X
.2562 X .2949 X .2922 X .5773 X
1.0000 12.0263
.7150 .1729 .9951 1.7697
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN N A M
** P A T H O L O G Y KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATI 0 N S * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
MANOIB/CERV LN ( M N 1 .................................................................................... ..............
GROSS: -LARGE
-LEFT: UP TO 16 X 10 X I MM (FOR COMPARISON. RIGHT IS
5 X 4 X 3 MM) (CAP 6 ]
MICRO: -MODERATE. MULTI-FOCAL
-HYPERPLASIA. LYMPHORETICULAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR|, COAGULATING GLD (CG). LF . TESTIS (TEO). LIVER |LI), LUNG (LU|, PROSTATE (PR). SEMINAL VESICLE |SV|. URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTEO: ll-OCT-91
PAGE: 24
ANIMAL NUMBER: C67474
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDY DAY OF DEATH: 57
STUDY WEEK OF DEATH: 9
TERMINAL BODY WEIGHT: 471.1 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 9:04
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR]1 LIVER fLX|1 LUNG (LU| LF. TE$TI$ (TEO) RT. TESTIS (TEI) ACCESS/SEX ORO (SO)
2.0492 17 5171
1 5651 1.7169 1 7*02 3.3959
.4216 X 3.6715 X
.3274 X .3591 X .3723 X .7103 X
1.0000 1.5124
.7631 .1371 .1617 1.6572
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S ** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) ......................... GROSS: -ALL T1SSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|, COAGULATING OLD (CGJ, LF . TESTIS (TEO). LIVER (LI|. LUNG (LU). PROSTATE (PR|. SEMINAL VESICLE (SV|. URETHRA |UR)
o
CO
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HUI 6329-100 PRINTED: 18-OCT-91
PAGE: 25
ANIMAL NUMBER: C67475
SEX: MALE
DOSE GROUP: l
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 567.4 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 (.50
PROSECTOR: KEVIN BILLINGS
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS 1
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BRI LIVER (LI) LUNG (LU) LF. TESTIS (TEOI RT. TESTIS (TEli ACCESS/SEX ORG (SO)
2.3230 20 4091
1.7(91 1 9015 1 9175 3.5652
.4094 X 3.5970 X
.3153 X .3351 X .3379 X .6213 X
1.0000 8.7857
.7702 .8186 .8254 1.5347
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT. TAKEN
ORGAN NAME
* PATHOL O G V OBSERVATIONS
KEYWOROS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCJ GROSS:
LIVER (LI) GROSS:
......................... -ALL TISSUES/ORGANS NORMAL
NECROPSY NOTE:
>TRIMMING COMMENT: ONLY ONE PIECE OF LIVER FOUND AT TIME OF TRIMMING.
IN WET
TISSUE
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CGI, LF TESTIS (TEO|, LIVER (Lit. LUNG (LU), PROSTATE (PR). SEMINAL VESICLE |SV), URETHRA (UR)
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 19-OCT-91
PAGE: 26
ANIMAL NUMBER: C67476
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 419.9 GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 9:39
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: OR. TOM PALMER
WEIGHER. PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS It e i I ACCESS/SEX 0RQ (SO)
2 0751 15.1597
1.4231 1.9496 1.9101 2.9944
.4942 X 3.7770 X
.3399 X .4405 X .4311 X .6993 X
1.0000 7.6429
.6959 .9913 .9723 1.3949
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S ** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR), COAGULATING OLD (CG|, LF . TESTIS (TEO), LIVER (LI), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR|
o
UNO)
N
O
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 16-OCT-91
PAGE: 27
ANIMAL NUMBER: C67477
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 420 1 GRAMS
DATE ANO TIME OF NECROPSY: 01/25/91 9:31
PROSECTOR: NANCY DIEDRICH
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR) LIVER |LI I LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORQ (SO)
1.9579 16.9711
1.6197 1.4154 1.396 2.3930
.4661 X 4.0414 X
.3150 X .3369 X .3325 X .5696 X
1.0000 1.6716
273 .7229 .7134 1.2222
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
O B S E R V A T I O N S * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION. BRAIN (BRJ. COAGULATING GLO (CG|, LF . TESTIS {TEO|, LIVER (LI). LUNG |LU|. PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 21
ANIMAL NUMBER: C6747I
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH 02/14/91
STUOY DAY OF DEATH: 57
STUDY WEEK OF DEATH. 9
TERMINAL BOOY WEIGHT: 474.1 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 (:01
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
OROAN WEIGHT RELATIVE TO BOOY WEIGHT (X|
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER ILI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1| ACCESS/SEX ORQ (SO)
2.0S05 16.6604
1.6043 1 6784 1.6448 3.4645
.4325 X 3.5160 X
.3314 X .3538 X .3469 X .7306 X
1 0000 6.1294
.7124 .8176 .8021 1.6896
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT. TAKEN
ORGAN NAME
P A T H O L O G Y O B S E R V A T I O N S **
KEYWORDS. SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). L F . TESTIS (TEO), LIVER (LI). LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
S0200
rwMo
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1S-0CT-91
PAGE: 29
ANIMAL NUMBER: C67479
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE DATE
OF DEATH AND TIME
05/17/91 OF NECROPSY:
STUDY 05/17/91
POST-FIX WEIGHER: NOT AVAILABLE
DAY OF 1:41
DEATH: 149
STUDY WEEK OF DEATH:
PROSECTOR: RUTH SCHMITZ
PATHOLOGIST: DR. TOM PALMER
22
TERMINAL BODY WEIGHT: 410.7 GRAMS RECORDER: JOE N. KIZZIEE WEIGHER: DENNIS HOFFMAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI 1 LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TElj ACCESS/SEX ORG (SO)
2.0754 14 3551
1.4153 1.5307 1.5101 2.4799
.4231 X 2.9316 X
.3033 X .3126 X .3227 X .5064 X
1.0000 6.9171
.7157 .7375 .7613 1.1949
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC| G3ROSS
LIVER (LI) MICRO
PROSTATE (PR) MICRO
-ALL TISSUES/ORGANS NORMAL -MINIMAL. FOCAL.......... -SLIGHT', MULTI-FOCAL
-INFILTRATES,MONONUCLEAR CELL -INFLAMIATiON, CHRONIC ACTIVE
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING OLD (CG). LF . TESTIS (TE0|. LUNG (LU|. SEMINAL VESICLE (SV|, URETHRA (UR)
ftsozoo
urwo
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-OCT-9L
PAGE: 30
ANIMAL NUMBER: C674I0
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDY DAY OF DEATH: 55
STUDY WEEK OF DEATH: I
TERMINAL BODY WEIGHT: 459 0 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 7:51
PROSECTOR: KEVIN BILLINGS
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER 2LI) LUNG (LU) LF. TESTIS (TE0| RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2.1222 16.4500
1.3140 1 7231 1.7252 2.6279
.4824 X 3.5139 X
.3015 X .3754 X .3759 X .6161 X
1.0000 7.7514
.6522 .1119 .1129 1.3325
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT |GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ................................... MICRO: -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR). COAGULATING GLD (CG). L F . TESTIS (TEO), LUNG |LU), PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA |UR|
o Q ?0
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 31
ANIMAL NUMBER: C67461
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDY DAY OF DEATH: 55
STUDY WEEK OF DEATH:
TERMINAL BODY WEIGHT: 435.1 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 9:07
PROSECTOR: KEVIN BILLINGS
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG |LU) LF. TESTIS ([TEO 1 RT. TESTIS (TE1 ACCESS/SEX Of(G (SO)
2.0951 15.4762
1.5414 1.5111 1.6946 2.5279
.4615 X 3.5569 X
.3543 X .3652 X .3195 X .5609 X
1.0000 7.3669
.7357 .7563 .6069 1.2064
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y ' O B S E R V A T I O N S * *
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
GENERAL COMMENT IGC1 .................................... ................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI| ..................................................................................
MICRO: -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|. COAGULATING GLD (CG). L F . TESTIS (TEO), LUNG |LU), PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR)
uiU-o1 <?> o
o0
HA2LET0N LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTEO: 1I-0CT-B1
PAGE: 32
ANIMAL NUMBER: C674I2
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL BOOY WEIGHT: 511.1 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 9:19
PROSECTOR: KEVIN BILLINGS
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS 1TE1) ACCESS/SEX ORG (SO)
2 1415 16 2911
1.6517 1.9007 1.1997 3.1952
.4191 X 3.1(46 X
.3241 X .3714 X .3712 X .6243 X
1.0000 7.5161
.7720 147 .(42 1.4(72
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY' OBSERVATIONS
KEYWORDS. SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COFMENT (GC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). LF TESTIS (TEO), LIVER (LI 1. LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (uAl
00209
OrJo
o\
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX O INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED. 1I-0CT-91
PAGE: 33
ANIMAL NUMBER: C67463
SEX: MALE
DOSE GROUP. 1
SACRIFICE STATUS: SCHEDULED, FIRST POST-RECOV SAC
DATE OF DEATH: 05/16/91
STUDY DAY OF DEATH: 146
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 615.4 GRAMS
DATE AND TIME OF NECROPSY: 05/16/91 1:00
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: OR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TCIi ACCESS/SEX ORG (SO)
2.2214 19.7955
1.5677 1.7633 1.7407 3.7565
.3610 X 3.2167 X
.2547 X .2665 X .2629 X .6107 X
1.0000 6.9113
.7057 .7936 .7636 1.6920
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ................................... MICRO: -MINIMAL. FOCAL
-INF LAMMATION,GRANULOMA TOUS
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR). COAGULATING GLD |CG), LF . TESTIS (TEO). LUNG |LU|. PROSTATE (PR). SEMINAL VESICLE (SV|, URETHRA (UR)
uwvi
002095
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 34
ANIMAL NUMBER: C674I4
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDY DAY OF DEATH: 55
STUDY WEEK OF DEATH:
TERMINAL BOOV WEIGHT: 416 7 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 1:13
PROSECTOR: NANCY DIEDRICH
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: OR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO I RT. TESTIS TE1 ACCESS/SEX ORO (SO)
2.1066 It 2573
1.7544 1.7414 1 7661 2.9663
.4332 X 3.7512 X
.3605 X .3592 X .3670 X .6140 X
1.0000 6.6565
.8320 .6292 .8471 1.4172
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIQHT TAKEN
ORGAN NAME
* * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS ** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING OLD (CO). L F . TESTIS (TEO), LIVER (LI). LUNG (LUJ. PROSTATE (PR). SEMINAL VESICLE (SV), URETHRA (UR)
r(ao)
CO
6
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOQY DATA
HWI 6329-100 PRINTED: 16-OCT-91
PAGE. 35
ANIMAL NUMBER: C674I5
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 595.6 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 7:50
PROSECTOR: KEVIN BILLINGS
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR) LIVER U l ) LUNG |LU) LF. TESTIS (TEOI RT. TESTIS m i l ACCESS/SEX ()RG (SO)
2.2154 21.0922
1.9451 1.9466 1.9120 2.9746
.3720 X 3.5413 X
.3333 X .3266 X .3210 X .4994 X
1.0000 9.5207
I960 .6767 .6630 1.3427
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * P A T H O L O G Y - O B S E R V A T I O N S *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR |, COAGULATING OLD (CG). LF. TESTIS (TE0|. LIVER (LI). LUNG <LU|, PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA IUR I
kN0l
to
ja?
HA2LET0N LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HUI 6329-100 PRINTED: lt-OCT-91
PAGE: 36
ANIMAL NUMBER: C674I6
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUDY DAY OF DEATH: 35
STUDY WEEK OF DEATH: 5
TERMINAL BODY WEIGHT: 397.0 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 9:45
PROSECTOR: NANCY DIEDRICH
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEOI RT. TESTIS TE1 ACCESS/SEX ORG (SOI
2.113 16.3091
1.5415 1.5441 1.5492 2.5(54
.5324 X 4.1011 X
.3913 X .3191 X .3902 X .6512 X
1.0000 7.7155
.7293 .730 .7329 1.2231
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L O G Y KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR), COAGULATING OLD (CG). L F . TESTIS (TEO), LIVER (LI). LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UA|
OOoll
^60200
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATH0L0QV DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 37
ANIMAL NUMBER: C674I7
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/25/91
STUDY DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: $23.4 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 1:19
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR| LIVER LI LUNG (LU) LF. TE STIS (TEO) RT. TESTIS TE1 ACCESS/SEX ORG (SO)
2.3602 17.4732
1.5735 1.7150 1.6768 4.2206
.4546 X 3.3364 X
.3006 X .3277 X .3203 X .6064 X
1.0000 7.3411
.6611 .7205 .7044 1.7733
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC I ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|. COAGULATING GLD (CG|, LF . TESTIS (TEO), LIVER (LI). LUNG (LU). PROSTATE (PR|. SEMINAL VESICLE (SV|. URETHRA (UR)
uui
^60200
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE: 31
ANIMAL NUMBER: C674II
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF OEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL BOOT WEIGHT: 621.2 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 7:22
PROSECTOR: STEVE VAN ADESTINE
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: OR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN LIVER
((BLRI||11
LUNG (LU|
LF. TESTIS (TEO)
RT. TESTIS (TEI
ACCESS/SEX ORG (SO)
2.2904 22.4633
1.7742 1.6540 1.6235 3.9901
.3617 X 3.6161 X
.2658 X .2663 X .2613 X .6423 X
1.0000 9.1076
.7746 .7221 .7016 1.7421
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y ' O B S E R V A T I O N S **
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COFMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN fSR), COAGULATING OLD (CQ), L F . TESTIS (TEO). LIVER (LI). LUNG (LU|, PROSTATE |PR), SEMINAL VESICLE (SV|, URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX 0 INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED. 16-OCT-91
PAGE: 39
ANIMAL NUMBER. C67489
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 382.7 GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 9:27
PROSECTOR: KEVIN BILLINGS
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR)
LIVER (LI I
LUNG (LU|
LF TESTIS ITEO)
RT. TESTIS ACCESS/SEX
ORGTE1 (SOI
2.1231 14.7941
.1781 1.8265 1.7483 2.6769
.5550 X 3.8859 X
.2296 X .4773 X .4568 X .6995 X
1.0000 6.9662
.4138 .8600 .8232 1.2604
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY1 OBSERVATIONS
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT
LIVER (LI)
J & l : -ALL TISSUES/ORGANS NORMAL
MICRO: -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR). COAGULATING GLD (CG). LF . TESTIS (TEOI. LUNG (LU|, PROSTATE (PR|, SEMINAL VESICLE (SV). URETHRA (UR)
uuui>
-$ 6 0 2 0 0
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 40
ANIMAL NUMBER: C67490
SEX: MALE
DOSE GROUP: I
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/16/91
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 22
TERMINAL BOOY WEIGHT: 610.6 GRAMS
DATE ANO TIME OF NECROPSY: 05/16/91 7:11
PROSECTOR: GAIL M. NOVAK
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS ITEO) RT. TESTIS (TEll ACCESS/SEX ()RG (SO)
2.0230 10.1409
1.6371 1.7120 1.1613 3.1663
.3313 X 3.2494 X
.2611 X .2911 X .3060 X .6332 X
1.0000 9.1077
.1092 .1109 .9235 1.9112
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT 1GC] ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI| ................................... MICRO; -SLIGHT. FOCAL
-INFILTRATES,MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|. COAGULATING OLD (CO). L F . TESTIS (TEO|, LUNG (LU). PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR)
o uu
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 329-100 PRINTED: 18-OCT-9I
PAGE. 41
ANIMAL NUMBER: C87491
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUDY DAY OF DEATH: 3S
STUDY WEEK OF DEATH: 5
TERMINAL BODY WEIGHT: 319.1 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 9:57
PROSECTOR: NANCY DIEDRICH
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS!
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER |LIi LUNG (LU| LF. TESTIS (TEOI RT. TESTIS 1TEI I ACCESS/SEX ORG (SOI
1.9387 14.4250
1.4507 1.500 1.5182 2.7280
.4995 X 3.7188 X
.3738 X .3887 X .3912 X .7029 X
1.0000 7.440
.7483 .7740 .7831 1.4071
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
*** P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) ......................... GROSS. -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING GLD |CG), L F . TESTIS (T0|. LIVER ILI I. LUNG (LU). PROSTATE (PR J. SEMINAL VESICLE |SV|. URETHRA |UR|
0OTZOO
wOUll
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOQY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 42
ANIMAL NUMBER: C67492
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 451.9 GRAMS
DATE AND TIME OF NECROPSY. 01/24/91 1:36
PROSECTOR: JULIE A. LARSEN
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
0 RGAN S TA TU S
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS ITEOJ RT. TESTIS tei ACCESS/SEX ORO (SO)
2.1730 23.3031
1.7054 1.7399 1 1369 3.2461
ORGAN NAME
PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
.4909 X 5.1567 X
.3774 X .3150 X .4065 X .7193 X
1.0000 10.7230
.7949 .9007 .9453 1.4939
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
OSSERVATI 0 N S GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEV(S) (KOI GROSS : -LARGE PELVIS(ES) MICRO : -PRESENT
LIVER (LI) MICRO : -MODERATE. FOCAL
-RIGHT: BOTH COLLECTED -OILATATION.PELVIC -INFLAMMATION.GRANULOMATOUS
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR) . COAGULATING OLD (CG). LF . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV), URETHRA (UR)
foTZOO
ttOonJ
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 43
ANIMAL NUMBER: C67493
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/17/91
STUDY DAY OF DEATH: 149
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 510.4 GRAMS
DATE AND TIME OF NECROPSY: 05/17/91 7:03
PROSECTOR: RUTH SCHMITZ
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR)1
LIVER LI)1 LUNG (LU)
'
LF. TESTIS (TEO)
RT. TESTIS (TEI
ACCESS/SEX ORO (SO)
2.0441 15.5493
1.5130 1.7096 1 1119 2.9256
.4005 X 3.0465 X
.2964 X .3350 X .3550 X .5732 X
1.0000 7.6069
.7402 .1364 .1164 1.4312
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* ** PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
SKIN
|SK|
................................................ ...............................................................
GROSS: -ABRASION!S)/ULCERATION!S|
-MID VENTRAL CERVICAL REGION: SINGLE ABRADED AREA. 30 X 10 MM
TAN AND MOIST (CAP 6|
MICRO. -SEVERE. FOCAL
-DERMATITIS
-SEVERE. FOCAL
-ULCERATION
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION. BRAIN |BR), COAGULATING OLD (CQ|. LF. TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HW1 6328-100 PRINTED: 18-OCT-91
PAGE: 44
ANIMAL NUMBER: C67494
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDY DAY OF DEATH. S7
STUDY WEEK OF DEATH: 9
TERMINAL BODY WEIGHT: 452.1 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 1:54
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOT WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER jLI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1J ACCESS/SEX ORG (SO)
2.1910 16.7526
1 6415 1 6606 1 6441 3 016S
.4962 X 3.7055 X
.3646 X .3673 X .3637 X .6672 X
1.0000 7.6217
.7500 .7555 .7490 1.3724
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
O B S E R V A T I O N S ** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IQC] .................................
..................................
GROSS: -ALL TISSUES/ORQANS NORMAL
PROSTATE (PR) ................................................................................
MICRO: -SLIGHT, FOCAL
-INFLAMMATION. CHRONIC ACTIVE
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). LF . TESTIS (TEO). LIVER (LI). LUNG (LU). SEMINAL VESICLE (SV). URETHRA (UR)
o T2G3
ttoo
CD
HAZLETON LABORATORIES AMERICA, INC. MAOISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 18-OCT-B1
PAGE: 45
ANIMAL NUMBER. CB7495
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDY DAY OF DEATH: 55
STUDY WEEK OF DEATH: I
TERMINAL BODY WEIGHT: 415.5 GRAMS
DATE AND TIME OF NECROPSY 02^12/91 9:11
PROSECTOR: RUTH SCHMITZ
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILAB
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (SR} LIVER (LI) LUNG (LU) LF. TESTIS 1TEO) RT. TESTIS (TEI ACCESS/SEX ()RG SO)
2.0117 11.0970
1.6654 1.6692 1.7320 3.4693
.4156 X 3.7275 X
.3430 X .3436 X .3567 X 7167 X
1.0000 6.9647
.6250 .6289 .6560 1.7285
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY1 OBSERVATIONS *
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IQCI .........................
GROSS: -ALL TISSUES/ORGANS NORMAL
LUNG (LU)
GROSS :
NECROPSY NOTE:
MICRO: -TISSUE MISSING
>TRIMMING COMMENT: OF TRIMMING
LUNG SECTION MISSING FROM WET
TISSUE AT TIME
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR). COAGULATING OLD (CGJ, LF. TESTIS (TEO), LIVER (LI), PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR)
fiOTZOO
Uttoo)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 18-OCT-91
PAGE: 46
ANIMAL NUMBER: C67496
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/16/91
STUDY DAY OF DEATH: 14*
STUDY WEEK OF DEATH. 22
TERMINAL BODY WEIGHT: 507.2 GRAMS
DATE AND TIME OF NECROPSY: 05/16/91 7.25
PROSECTOR. JULIE A. LARSEN
RECORDER: JOE N. KIZ2IEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT ,
ORGAN NAME
ABSOLUTE OROAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI! LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2 0397 15.7533
1.5019 1.7336 1.1395 3.2306
4021 X 3.1050 X
.2961 X .341 X .3627 X .6366 X
1.0000 7.7233
.7363 .1499 .9011 1.5(39
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY' O B S E R V A T I O N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
GENERAL C O G E N T IOC) .............................................................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
GENERAL INFORMATION IKK) .........................................................................................................
GROSS:
NECROPSY NOTE: >WART-LIKE LESION (HEAD) NOTED IN CLINICAL OBSERVATIONS.
INADVERTENTLY NOT COMMENTED ON AS TO ABSENCE OR PRESENCE AT TIME
OF NECROPSY
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN JBR), COAGULATING GLD (CO). LF TESTIS (TEO). LIVER (LI). LUNG (LU|. PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
JOTZGO
u> .O* *
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: II-OCT-91
PAGE: 47
ANIMAL NUMBER: C67497
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/17/91
STUDY DAY OF DEATH: 149
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 597.7 GRAMS
DATE AND TIME OF NECROPSY: 05/17/91 7:37
PROSECTOR: RUTH SCHMITZ
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEOl RT. TESTIS ITE1 ACCESS/SEX ORG (SO)
2.2377 19.00SS
1 5723 1.6211 1.6645 3.9372
3744 X 3.1791 X
.2631 X .2725 % .2715 X .6517 X
1.0000 1.4933
.7026 .7279 .7431 1.7595
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOGY' OSSERVATI 0N S
KEYWORDS, SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER (LI) SPLEEN (SP)
MICRO GROSS MICRO
-SLIGHT. FOCAL -CYST(S) -PRESENT
-INFLAMMATION.GRANULOMATOUS -VENTRAL SURFACE : SINGLE CYST. 2 MM IN DIAMETER. FILLED WITH CLEAR FLUID (COLLECTED) -CYST. SEROSAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG|, LF. TESTIS (TE0|. LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
ptOTZO
HAZLETON LABORATORIES AMERICA. INC. MAOISON, WISCONSIN U.S.A,
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 49
ANIMAL NUMBER: C6749I
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/01
STUDY DAY OF DEATH: 56
STUDY WEEK OF DEATH: t
TERMINAL BODY WEIGHT: 506.0 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 7:59
PROSECTOR: DENNIS HOFFMAN
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR| LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TEI ACCESS/SEX ()RG (SO)
2 1556 21.5097
1.5932 1.5765 1.5739 3.3224
.4260 X 4.2507 X
.3129 X .3116 X .3110 X .6566 X
1.0000 9 9791
.7345 .7314 .7301 1.5413
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * PATHOLOGY- O B S E R V A T I O N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
LUNG
(L U 1
.......................................................................................................
GROSS: -MOTTLED
-ALL LOBES: RED AND DARK RED
MICRO: -UNREMARKABLE
HISTOPATHOLOGICAL COMMENT: >NO MICROSCOPIC CORRELATE TO GROSS OBSERVATION.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD |CG), L F . TESTIS (TEO), LIVER (LI). PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
A0T200
ru4oki
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 49
ANIMAL NUMBER: C67499
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL OOY WEIGHT: 577.0 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 8:27
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER ILI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1 ACCESS/SEX ORG (SO)
2.2040 18 5020
1.6464 1.8157 1.8028 3.8600
.3820 X 3.2066 X
.2853 X .3147 X .3124 X .6690 X
1.0000 8.3047
.7470 .8238 .8180 1.7514
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * P A T H O L O G Y - O B S E R V A T I O N S **
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING OLD |CG>, L F . TESTIS (TEO), LIVER (LI). LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HUI 6329-100 PRINTED: 1I-OCT-B1
PAGE: SO
ANIMAL NUMBER: C67500
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/01
STUDY DAY OF DEATH: 3S
STUDY WEEK OF DEATH: S
TERMINAL 6oOV WEIGHT: 401.7 GRAMS
DATE AM) TIME OF NECROPSY: 01/23/91 7:S0
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR11
LIVER LUNG
(L(UL)I!1
LF. TESTIS (TEO 1
RT. TESTIS (TEI)
ACCESS/SEX ORO (SO)
2.0014 15.5319
1.5614 1.6913 1.6935 2.4646
.4962 X 3.6663 X
.3667 X .4210 X .4216 X .6136 X
1.0000 7.7640
.7602 .6451 .6462 1.2315
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY' OBSE RV AT IO NS *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (QC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING GLD (CG). L F . TESTIS (TEO). LIVER (LI), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|, URETHRA (UR)
N
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: II-OCT-01
PAGE: SI
ANIMAL NUMBER: C67S01
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/25/91
STUOY DAY OF DEATH: 98
STUOV WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 511.0 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 9:31
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR) LIVER }LI) LUNG (LU) LF. TESTIS (ITEO) RT. TESTIS |TEl 1 ACCESS/SEX OfIQ (SO)
2.1125 11.9192
1.6017 1.5330 1.5214 3.3014
.4271 X 3.7024 X
.3141 X .3000 X .2991 X .6461 X
1.0000 1.6616
.7371 .7024 .7003 1.5127
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y ' O B S E R V A T I O N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (OC I ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BRI, COAGULATING OLD (CG), LF. TESTIS (TEO), LIVER (LII. LUNG (LU), PROSTATE (PR). SEMINAL VESICLE |SV). URETHRA (Ulh
CO
oO
-*k
cn
N
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 52
ANIMAL NUMBER: C67502
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 6
TERMINAL BOOY WEIGHT: 409.0 GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 7:50
PROSECTOR: NANCY DICDRICH
RECORDER: NANCY DIEDRICH
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT 1GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR | LIVER iLIj LUNG (LU| LF. TESTIS (TEO) RT. TESTIS (TE1I ACCESS/SEX ORG (SO)
2 0266 16 5645
1.4431 1 6655 1.6449 2.6034
.4955 X 4.0500 X
.3828 X .4072 X .4032 X .8385 X
1.0000 4.1735
.7314 .4214 .4138 1.2448
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
OROAN NAME
PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ................................... MICRO: -SLIGHT, FOCAL
INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG|, L F . TESTIS (TEO). LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (U R )
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: S3
ANIMAL NUMBER: C67503
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/9!
STUOV DAV OF DEATH: 39
STUDY WEEK OF DEATH:
TERMINAL BODY WEIGHT: 411.1 GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 1:19
PROSECTOR: JULIE A. LARSEN
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: OR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT IGRAMS|
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR I LIVER (LI} LUNG (LU) LF. TESTIS (TEOI RT TESTIS It e u ACCESS/SEX ()RQ (SO)
2.0221 15 5999
1.6163 1 6037 1.6466 2.6669
.4626 X 3.7246 X
.3156 X .3126 X .3632 X .6361 X
1.0000 7.7147
.7663 .7931 .1143 1.3119
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN 1BRI, COAGULATING OLD (CGI. I F . TESTIS (TEO). LIVER (Lit, LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA IUR|
*^TT200
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE: 54
ANIMAL NUMBER : C67504
SEX: HALE
OOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL BOOY WEIGHT: 900.3 GRAMS
DATE AND TIME OF NECROPSY 03^22/91 9:31
PROSECTOR: KEVIN BILLINGS
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILAB
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN LIVER
(BR1 (LI)
'
LUNG |LU)
LF. TESTIS (TEOI
RT. TESTIS (TEI
ACCESS/SEX ()RG (SO)
2.1334 21 1053
1 1414 1 1115 1.7134 2.6144
.3554 X 3.5151 X
.3067 X .3029 X .2971 X .4355 X
1 0000 9.1921
.1631 .1524 .1359 1.2255
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COfWENT (OC I G9RCOSS: -ALL TISSUES/ORGANS NORMAL
LIVER ILI I MICRO: -MINIMAL. FOCAL..........
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD ICQ). L F . TESTIS (TEO). LUNG (LU). PROSTATE |PR|. SEMINAL VESICLE (SV). URETHRA (UR|
COZll
CD
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1S-OCT-91
PAGE: 55
ANIMAL NUMBER: C67505
SEX: MALE
DOSE GROUP: 1
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH. 03/22/91
STUDY DAY OF DEATH: 93
STUOY WEEK OF DEATH: 14
TERMINAL ODY WEIGHT: 549.9 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 9:22
PROSECTOR: RUTH SCHMITZ
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR)
LIVER (LI)
LUNG (LU)
LF. TESTIS (TEO)
RT TESTIS ACCESS/SEX
()RiGlEl fSO)
2.1167 19.6743
1.5119 1.6139 1.6292 3.3370
.3957 X 3.S9SO X
.2755 X .2941 X .2967 X .6091 X
1.0000 9.2949
.7142 .7624 .7692 1.5765
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y ' O B S E R V A T I O N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) GROSS : -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR| , COAGULATING GLD (CG). L F . TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE (PR), SEMINAL VESICLE (SV|. URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 56
ANIMAL NUMBER: C87508
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDY DAY OF DEATH: 57
STUDY WEEK OF DEATH: 9
TERMINAL ODY WEIGHT: 441.4 GRAMS
DATE ANO TIME OF NECROPSY: 02/14/91 1:42
PROSECTOR: RUTH SCHMITZ
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER jLI| LUNG (LU) LF TESTIS (TEOI RT. TESTIS (TEI f ACCESS/SEX (>RQ (SO)
2.0323 15.2133
1 5973 1.6141 1.6619 3.1539
.4604 X 3.4466 X
.3619 X .3115 X .3765 X .7145 X
1.0000 7.4659
.7960 .9297 .9177 1.5519
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS ** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). L F . TESTIS (TEO1. LIVER (LI I. LUNG (LU), PROSTATE (PR|, SEMINAL VESICLE (SV). URETHRA |UR)
uUo1
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-B1
PAGE: ST
ANIMAL NUMBER: C67S07
SEX: HALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL BOOY WEIGHT: 527.0 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 S:24
PROSECTOR: KEVIN BILLINGS
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI| LUNG (LU) LF. TESTIS (TEO ) RT. TESTIS (TE1 ) ACCESS/SEX ORQ (SO)
3.1322 16.9792
1.5175 1.9512 1.9094 3.1032
.5943 X 3.2219 X
.2190 X .3702 X .3623 X .5111 X
1.0000 5.4209
.4145 .6229 .6096 .9907
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATI 0 NS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL C0M4ENT (GC ) .................................... GROS!S: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BRI COAGULATING GLO (CQ|. L F . TESTIS (TEOI, LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
Uul>
ATTZO
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: SI
ANIMAL NUMBER: C6750I
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, FIRST POST-RECOV SAC
DATE OF DEATH: 05/16/91
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 22
TERMINAL BOOY WEIGHT: 563.4 GRAMS
DATE AND TIME OF NECROPSY: 05/16/91 1:52
PROSECTOR: GAIL M. NOVAK
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1I ACCESS/SEX ORG (SO)
2.1100 11.9139
1.7534 1 5465 1.6334 3.1153
.3169 X 3.3571 X
.3112 X .2745 X .2199 X .6772 X
1.0000 1.6761
.1043 .7094 .7493 1.7501
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S ** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT JQC) .................................
.........................
GROSS: -ALL TISSUES/ORGANS NORMAL
LF. TESTIS (TEO) ...................................................................
MICRO: -SLIGHT. FOCAL
-ATROPHY/DEGENERATION
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CGI. LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV), URETHRA (UR)
ey
O
Uor)o
K
h*
f-*
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329*100 PRINTED: 19-OCT-B1
PAGE: 59
ANIMAL NUMBER: C67509
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH 36
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 464.1 GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 6.56
PROSECTOR: DENNIS HOFFMAN
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU| LF. TESTIS (TEO) RT TESTIS (TE1) ACCESS/SEX ORG (SO)
1.9307 17.4500
1.6690 1.7267 1.7032 2.6041
.4154 X 3.7543 X
.3634 X .3719 X .3664 X .6033 X
1.0000 9.0362
.6746 .6954 .6622 1.4524
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATH OL OG Y' O B S E R V A T I O N S
KEYWORDS, SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ................................. ,.....................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ..................................................................................
MICRO. -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR), COAGULATING OLD |CG|. LF. TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR i
u1U7iI1
TTICO
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX O INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 60
ANIMAL NUMBER: C67S10
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL BOOY WEIGHT: 390.4 GRAMS
DATE AND TIME OF NECROPSY 01^24/91 9:09
PROSECTOR: DENNIS HOFFMAN
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILAB
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR) LIVER (LI) LUNG (LU| LF. TESTIS TEO RT. TESTIS (TEI 1 ACCESS/SEX (M G (SO)
2.0904 14.2679
1.6091 1.6477 1.6491 3.1326
.5355 X 3.6547 X
.4123 X .4221 X .4224 X .6024 X
1.0000 6.1254
.7701 .71*2 .7119 1 .49*6
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS I HISTOPATHOLOGIC FINDINGS
GENERAL COPWENT |0C] ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) .................................... MICRO: -SLIGHT. FOCAL
INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). L F . TESTIS (TEO), LUNG (LU). PROSTATE |PR). SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 19-0CT-B1
PAGE: 61
ANIMAL NUMBER: C67S11
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 399.2 GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 9:23
PROSECTOR: KEVIN BILLINGS
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE P1RKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF TESTIS (TEO) RT. TESTIS (TE11 ACCESS/SEX ORG (SOI
1 9731 14 2649
1.4519 1.6229 1.6199 2.9169
.4944 X 3.5734 X
.3655 X .4065 X .4051 X .7307 X
1.0000 7.2271
.7391 .9222 .9207 1.4779
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y ' O B S E R V A T I O N S ***
KEYWORDS. SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
GENERAL COMMENT IGCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BRK COAGULATING GLD (CG), L F . TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE ISV), URETHRA tuft)
D
CO
Q utni
10
b
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 18-OCT-91
PAGE: 62
ANIMAL NUMBER: C67512
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF OEATH: S6
STUDY WEEK OF DEATH. I
TERMINAL BODY WEIGHT: 440.1 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 1:00
PROSECTOR: RUTH SCHMITZ
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TElj ACCESS/SEX ORG (SO)
2.0451 15*500
1.6105 1.5562 1.4(31 3.0679
.4647 X 3.6015 X
.3111 X .3536 X .3370 X .6971 X
1.0000 7.7502
.1217 .7609 .7252 1.5001
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y ' O B S E R V A T I O N S * *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
MANDIB/CERV LN ( M N ) ...................................... ...........................................................
GROSS: -LARGE
-LEFT: UP TO 16 X 11 X 6 MM IFOR COMPARISON RIGHT IS
6 X 4 X 2 MM| (CAP 61
MICRO: -MODERATE. MULTI-FOCAL
-HYPERPLASIA. LYMPHORETICULAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|. COAGULATING OLD (CGI. LF . TESTIS (TEO). LIVER (LI|. LUNG |LU|, PROSTATE |PR|. SEMINAL VESICLE (SV|. URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HUI 6329-100 PRINTED: 18-OCT-91
PAGE: 63
ANIMAL NUMBER: C67513
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, FIRST POST-RECOV SAC
DATE OF DEATH: 05/17/91
STUDY DAY OF DEATH: 149
STUOY WEEK OF DEATH: 22
TERMINAL ODY WEIGHT: 660.3 GRAMS
DATE AND TIME OF NECROPSY: 05/17/91 1:07
PROSECTOR: RUTH SCHMITZ
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (%)
ORGAN TO 8RAIN WEIGHT RATIO
ORG A N S TA IU S
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TE01 RT. TESTIS (TEI 1 ACCESS/SEX ORG (SO)
2.2957 21.4361
1.90SI 1.6522 1.7142 3.9260
.3375 X 3.1511 X
.2601 X .2429 X .2520 X .5771 X
1.0000 9.3376
.8302 .7197 .7467 1.7102
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * P A T H O L O G V' O B S E R V A T I O N S
KEYWORDS, SEVERITY. DISTRIBUTION
OROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
GENERAL COMMENT (GC) GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR), COAGULATING1 GLD (CGI, LF. TESTIS (TEO).. LUNG (LU). PROSTATE (PR) . SEMINAL VESICLE (SV). URETHRA (UR)
GJ in
o
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 10-OCT-91
PAGE: 64
ANIMAL NUMBER. C67S14
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 440.2 GRAMS
DATE ANO TIME OF NECROPSY: 01/24/91 7:03
PROSECTOR: JULIE A. LARSEN
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF TESTIS (TEO) RT. TESTIS (TEli ACCESS/SEX ORG (SO)
2.1070 16.1693
1.5906 1 1031 1 7679 2.6662
.4786 X 3.6732 X
.3613 X .4098 X .4016 X .6061 X
1 0000 7 6741
.7S49 .8561 .8391 1.2664
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * * P A T H O L O G Y - O B S E R V A T I O N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) ........................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ..................................................................................
MICRO. -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). L F . TESTIS (TEO). LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
feTZOO
UUJl
CD
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 18-OCT-91
PAGE: 65
ANIMAL NUMBER. C67S15
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUOV WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 396.0 GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 7:16
PROSECTOR: JULIE A. LARSEN
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORG A N S TA TU S
BRAIN (BR|
LIVER (LI 1
LUNG (LU)
LF. TESTIS (TE1
RT. TESTIS ACCESS/SEX
iORGTEI (SO)
1.9S49 14.9406
1.4192 1.5906 1.5946 2.2112
.4937 X 3.7729 X
.3761 X .4017 X .4027 X .5564 X
1.0000 7.8426
.7611 .1136 .1157 1.1311
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * * P A T H O L O G Y . O B S E R V A T I O NS *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI GROSS : -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL. MULTI-FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR ). COAGULATINGI GLD (CG|. LF. TESTIS |TEO )., LUNG (LU). PROSTATE (PR) . SEMINAL VESICLE (S V ). URETHRA (UR)
u iMn>
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 66
ANIMAL NUMBER: C67516
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: OS/16/91
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 671.1 GRAMS
DATE AND TIME OF NECROPSY: OS/16/91 1:17
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. KI2ZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR | LIVER |LI| LUNG (LU| LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2.2907 19.1095
1.9520 1.1636 1.6377 3.2904
.3375 X 2.9163 X
.2676 X .2775 X .2707 X .4647 X
1.0000 6 6476
.6521 .6223 .6022 1.4364
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L O G Y ' O B S E R V A T I O N S **
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT tGC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|, COAGULATING OLD (CG|. L F . TESTIS (TEO). LIVER (LI). LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
(TV o
Uool>
N
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED ll-OCT-91
PAGE: 67
ANIMAL NUMBER: C67517
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/17/91
STUDY DAY OF DEATH: 149
STUDY WEEK OF DEATH: 22
TERMINAL BOOT WEIGHT: 611.1 GRAMS
DATE AND TIME OF NECROPSY: 05/17/91 9:33
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DENNIS HOFFMAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE11 ACCESS/SEX ORG (SO)
2 2742 19.9402
1.6369 2.0113 2.1674 4.2763
.3675 X 3.0609 X
.2645 X .3250 X .3503 X .6911 X
1.0000 9 3293
.7199 .9944 .9530 1.9904
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * PATHOLOGY' O B SE RV AT IO NS
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) .................................... ..................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI | ..........................................................., .....................
MICRO: -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|, COAGULATING GLO (CG|, LF . TESTIS (TEG). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
QZJZCO
wo
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAQE: 61
ANIMAL NUMBER: C67S19
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/28/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL ODY WEIGHT: 467.2 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 9:04
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT 1GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR]1
LIVER LUNG
1LI (LU)
11
LF. TESTIS (TEO)
RT. TESTIS (TEI)
ACCESS/SEX ORG (SO)
2.0016 14.0143
1.3781 1.6312 1.7067 3.1439
.4299 X 2.9996 X
.2950 X .3491 X .3653 X .6729 X
1.0000 6.0771
.6161 .1121 .1497 1.5652
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TKKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN 1BR|. COAGULATING OLD (CG). L F . TESTIS (TEO), LIVER (LI|, LUNG <LU), PROSTATE (PR). SEMINAL VESICLE (SV), URETHRA (UR)
o
K Ul h * rv>
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE: 69
ANIMAL NUMBER: C67S19
SEX. MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: SIS.4 GRAMS
OATE AND TIME OF NECROPSY: 03/26/91 1:43
PROSECTOR: DEBBIE PIRKEL
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N KIZZIEE
ORGAN NAME
ABSOLUTE (MIGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG |LU) LF. TESTIS (TEO) RT. TESTIS (TEI ACCESS/SEX ()RG (SO)
2.1131 16.7043
1.6032 l .1623 1.1267 3.0411
.4100 X 3.2410 X
.3111 X .2255 X .3544 X .5914 X
1.0000 7.9051
.7517 .5500 .I64S 1.4425
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y ' O B S E R V A T I O N S * * *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LF. TESTIS CTEOI ..................... GROSS: -SMALL MICRO: -MODERATE, DIFFUSE -MOOERATE, FOCAL
LIVER (LI I MICRO: -MINIMAL. FOCAL
-II X 10 MM IFOR COMPARISON RIGHT IS 25 X 15 X 10 MM) -ATROPHV/DEGENERATION -INFLAMMATION, GRANULOMATOUS -INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR). COAGULATING GLD |CG), LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
gzrzoo
aut
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6320-100 PRINTED: ll-OCT-91
PAGE: 70
ANIMAL NUMBER: C67S20
SEX: MALE
DOSE GROUP. 2
SACRIFICE STATUS. SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH. 05/17/91
STUDY DAY OF DEATH: 149
STUDY WEEK OF OEATH: 22
TERMINAL OOY WEIGHT: 551.1 GRAMS
DATE AND TIME OF NECROPSY: 05/17/91 1:02
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR!1
LIVER LUNG
(LI (LU)
I1
LF. TESTIS 1TEO I
RT. TESTIS (TEI
ACCESS/SEX ORG (SO)
2.2930 15.8640
1 6561 1.7256 1.7061 4.2444
.4161 X 2.6459 X
.3009 X .3132 X .3099 X .7702 X
1.0000 6.6399
.7231 .7526 .7449 1.6510
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY' O B S E R V A T I O N S *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) ...............................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER a n .........................................................................
MICRO: -SLIGHT. FOCAL
-NECROSIS.COAGULATIVE
-SLIGHT. MULTI-FOCAL
-HYPERPLASIA.BILE DUCT
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG|, LF. TESTIS (TEO), LUNG (LU). PROSTATE (PR|. SEMINAL VESICLE (SV). URETHRA (UR)
UOr
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE: 71
ANIMAL NUMBER: C67521
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS. SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL BOOY WEIGHT: 557.6 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 9:43
PROSECTOR: KEVIN BILLINGS
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR) LIVER (LI) LUNG (LU| LF. TESTIS (TEOI RT. TESTIS (TEI ACCESS/SEX ()RG (SO)
2.2002 16.9153
1. 7320 1.5141 1.6421 3.4940
.3946 X 3.0461 X
.3106 X .2141 X .2945 X .6266 X
1.0000 7.7199
.7972 .7200 .7463 1.5990
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* ** PATHOLOGV KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S ** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BRI, COAGULATING GLD (CGI. LF . TESTIS (TEO|. LIVER (LI 1. LUNG (LU|, PROSTATE (PR|, SEMINAL VESICLE (SV|. URETHRA (UA|
002131?
uoc?>n
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 72
ANIMAL NUMBER: C67S22
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDY DAY OF DEATH: 55
STUDY WEEK OF DEATH: I
TERMINAL OOV WEIGHT: 525.9 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 7:49
PROSECTOR: RUTH SCHMITZ
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN IBR1 LIVER (LI) LUNG (LU) LF. TESTIS 1TEO1 RT. TESTIS }TE1) ACCESS/SEX ORG (SO)
2.0794 21.9991
1 5173 1 7894 1.7859 3.3206
.3954 X 4.1133 X
.3019 X .3365 X .3396 X .6314 X
1.0000 10.5799
.7633 .1509 .1519 1.5969
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLO G V OSSERVATI 0 N S * *
KEYWORDS. SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) . . GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING1 OLD (CO). LF. TESTIS (TEO),, LIVER (LI|, LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 16-OCT-91
PAGE: 73
ANIMAL NUMBER: C67S23
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL BOOY WEIGHT: 613.6 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 1:32
PROSECTOR: DEBBIE PIRKEL
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIQHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN IBR
LIVER LUNG
ILI (LUI
LF. TEs u s 1TE0
RT. TESTIS (TEI
ACCESS/SEX ORG SO)
2.1766 206353
1.7937 1.6941 1 6579 3.2076
.3551 X 3.3956 X
.2923 X .3067 X .3026 X .5226 X
1.0000 9.5627
.6233 .6693 .6527 1.4722
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
N NAME
... pa T H 0 L 0 G V O S S E R V A T I 0 N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING OLD (CO). L F . TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|, URETHRA (UA)
uo>>
*4
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HUI 6329-100 PRINTED: lt-OCT-91
PAGE: 74
ANIMAL NUMBER: C67S24
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUDY DAY OF DEATH. 3S
STUDY WEEK OF DEATH. 5
TERMINAL BODY WEIGHT. 376.6 GRAMS
OATE AND TIME OF NECROPSY: 01/23/91 7:16
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER |LI| LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2.0306 15.1071
1.3165 1.3102 1.3303 2.5370
.5392 X 4.1973 X
.3501 X .3479 X .3532 X .6737 X
1 0000 7.7644
.6493 .6452 .6551 1.2494
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). L F . TESTIS (TE0|. LIVER (LI), LUNG |LU), PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
CT205
uCT>
00
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-OCT-91
PAGE: 75
ANIMAL NUMBER: C67S2S
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUDY DAY OF DEATH: 35
STUDY WEEK OF DEATH: 5
TERMINAL BOOY WEIGHT: 434.7 GRAMS
DATE ANO TIME OF NECROPSY: 01/23/91 7.22
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN IBRI LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TElj ACCESS/SEX o Ag (SO)
1.6931 17.1115
1.5590 1.1906 1.1599 2.7211
.4355 X 4.0990 X
.3586 X .4349 X .4279 X .6260 X
1.0000 9.4123
.6235 .9917 .9825 1.4374
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L O G Y ' O B S E R V A T I O N S *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR| COAGULATING OLD (CG). LF . TESTIS (TEO), LIVER (LI ). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE <SV|. URETHRA (UA)
CT
KO
^ETZO
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE: 76
ANIMAL NUMBER: C67S26
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/25/91
STUOY DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL 600Y WEIGHT: 513.2 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 10:07
PROSECTOR: JACK SERFORT
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF TESTIS (TEO) RT. TESTIS (TE1i ACCESS/SEX ORG (SO)
2.1591 IS 4771
1 5033 1.6993 1.7274 2.9030
.4201 X 3.0151 X
.2929 X .3311 X .3366 X .5657 X
1.0000 7.1660
.6960 .7161 .7996 1.3441
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* ** PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORQANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR), COAGULATING OLD |CG|, LF . TESTIS (TEO), LIVER (LI), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
(A> o
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE: 77
ANIMAL NUMBER: C67527
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH: 56
STUDY WEEK OF DEATH: 9
TERMINAL BODY WEIGHT: 495.1 GRAMS
DATE ANO TIME OF NECROPSY 02/13/91 1.51
PROSECTOR. RUTH SCHMITZ
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER jLI 1 LUNG (LU) LF. TESTIS (TEOJ RT. TESTIS (TEI | ACCESS/SEX ORO (SO)
2 2223 16 3032
1.7484 1.7954 1.1030 3.2105
.4489 X 3.2929 X
.3531 X .3626 X .3642 X .6485 X
1.0000 7.3362
.7868 .8079 .8113 1.4447
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y . O B S E R V A T I O N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (OC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR) COAGULATING OLD (CG). LF . TESTIS (TEOJ, LIVER (LI1 . LUNG (LU). PROSTATE (PRJ. SEMINAL VESICLE (SV). URETHRA (UA)
to
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 16-OCT-91
PAGE: 7S
ANIMAL NUMBER: C87S2I
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH. 05/17/91
STUDY DAY OF DEATH: 149
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 567.1 GRAMS
DATE AND TIME OF NECROPSY: 05/17/91 7:30
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER. HOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR)
LIVER (LI)
LUNG (LU)
LF. TESTIS (TEO)
RT. TESTIS ACCESS/SEX
ORGTE1 (SO)
2.2437 17.2706
1.5660 1.7632 1.7366 3 6242
.3952 X 3.0417 X
.2762 X .3105 X .3056 X .6363 X
1.0000 7.6974
.6966 .7656 .7740 1.6153
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y ' O B S E R V A T I O N S
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI .......................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ..................................................................................
MICRO: -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). LF . TESTIS |TEO|, LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
A ctsoo
ro
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1S-OCT-01
PAGE: 79
ANIMAL NUMBER: C67529
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 404.S GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 1:47
PROSECTOR: KEVIN BILLINGS
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER. DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR|
LIVER (LI) LUNG (LU)
'
LF TESTIS tTEOI1
RT. TESTIS Itei
ACCESS/SEX (JRG j[SO)
2.1694 14.7411
1 4026 1.7652 1.7033 2.5456
.5363 X 3.6443 X
.3467 X .4364 X .4211 X .6293 X
1.0000 6 7950
.6465 .1137 .7851 1.1734
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
OSSERVATI 0 NS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCJ1 .................................... GROS!>: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|, COAGULATING GLD (CG|, L F . TESTIS (TEO|. LIVER (LI). LUNG (LU|. PROSTATE |PR|. SEMINAL VESICLE (SV|, URETHRA (UA)
&TZQ
U)
*v (
ItJ
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1S-0CT-91
PAGE. 10
ANIMAL NUMBER: C67S30
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUDY DAY OF DEATH: 35
STUDY WEEK OF DEATH: 5
TERMINAL BODY WEIGHT: 422.6 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 9:20
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1f ACCESS/SEX ORG (SO)
2 1161 14 7171
1 5517 1.5795 1 5950 2.6396
.5007 X 3.4127 X
.3661 X .3736 X .3774 X .6247 X
1.0000 6.9552
.7366 .7464 .7537 1.2475
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y' O B S E R V A T I O N S *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT |GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ................................... MICRO: -MINIMAL, FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). L F . TESTIS (TEO), LUNG |LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENOIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: II
ANIMAL NUMBER: C67531
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDY DAY OF DEATH: SS
STUDY WEEK OF DEATH: I
TERMINAL BODY WEIGHT: 524.1 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 1:25
PROSECTOR: KEVIN BILLINGS
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR) LIVER (LI) LUNG (LU) LF. TESTIS ([TEOl RT. TESTIS |TE1 ACCESS/SEX Of\Q (SOI
2.0324 19.1474
1.5564 1.5163 1.5311 2.7317
.3173 X 3.7119 X
.2966 X .3023 X .2917 X .5219 X
1.0000 9.7655
.7651 .7105 .7533 1.3475
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY' OB SE RV A T I O N S
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). LF . TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR)
GO2140
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 12
ANIMAL NUMBER: C67532
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDY DAY OF DEATH: S5
STUDY WEEK OF DEATH: I
TERMINAL ODY WEIGHT: 94.2 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 9:44
PROSECTOR: KEVIN BILLINGS
RECOROER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS TO RT. TESTIS (TEI ACCESS/SEX ()RG (SO)
2.0003 17 3673
1 369 1 7019 1 7102 3 0757
.4131 X 3.5969 X
.2121 X .3515 X .3532 X .6352 X
1 0000 9.6923
.6946 .9509 9550 1.5376
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y . O B S E R V A T I O N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR). COAGULATING GLO (CG). L F . TESTIS (TE0|. LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE fSV). URETHRA (uA)
OJ T*
h*
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-OCT-B1
PAGE: (3
ANIMAL NUMBER: C67533
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/2S/91
STUDY DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL BOOY WEIGHT: NOT ENTERED
DATE AND TIME OF NECROPSY: 03/25/91 9:23
PROSECTOR: JACK SERFORT
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT 1GRAMS 1
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR)1 LIVER (LI)1 LUNG (LU| LF TESTIS (TEO) RT. TESTIS (TEI 1 ACCESS/SEX ORG (SOI
2 0136 It 5414
1.4960 1.6960 1 6749 3.5576
1.0000 t .1917
.7110 .1140 .1031 1.7074
EXCLUDE EXCLUDE EXCLUDE EXCLUDE EXCLUOE EXCLUDE
ORGAN NAME
" P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S ** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) .................................
.................................... .............................
GROSS: -ALL TISSUES/ORGANS NORMAL
GENERAL INFORMATION (XX| ...................................................................................................
GROSS:
NECROPSY NOTE: >TERMINAL BOOY WEIGHT INADVERTENTLY NOT TAKEN PRIOR TO BLOOD
COLLECTION AND NECROPSY
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN JBR). COAGULATING GLD (CQ). LF . TESTIS (TEO). LIVER (LI). LUNG (LU), PROSTATE (PR). SEMINAL VESICLE |SV). URETHRA (UR)
'X'TZQO
u
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 14
ANIMAL NUMBER: C67534
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 0S/16/91
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 610.9 GRAMS
DATE AND TIME OF NECROPSY: 05/16/91 1:20
PROSECTOR: DEBBIE PIRKEL
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIOHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X|
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO RT. TESTIS Itei ACCESS/SEX RG SO)
2.1679 17.1901
1 7502 1 9921 1 1614 3 5969
.3549 X 2.9139 X
.2965 X .3097 X .3047 X .5972 X
1.0000 7.9294
.9073 .9729 .9596 1.6546
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * P A T H 0 L 0 GY' O B S E R V A T I 0 N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC] ............................... GROS!,: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR I, COAGULATING OLD (CG). LF TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE (PR), SEMINAL VESICLE (SV|. URETHRA (UR)
&T20D
u-- i
00
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-OCT-9I
PAGE: 15
ANIMAL NUMBER: C67S35
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF OEATH: 03/22/91
STUDY DAY OF DEATH. 93
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 549.3 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 1:10
PROSECTOR: RUTH SCHMITZ
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER. NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS 1
(MOAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (Bit) LIVER (LI 1 LUNG 1LU 1 LF. TE STIS (TEOI RT. TESTIS |TE1) ACCESS/SEX ORG (SO)
2.1017 17.0119
1.6975 1.9135 1.9137 3.5420
.3139 X 3.0970 X
.3090 X .3414 X .3414 X .6441 X
1.0000 6.0675
.1050 .9074 .9075 1.6797
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY' OBSERVATIONS
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR), COAGULATING GLD |CG), LF. TESTIS (TEO). LIVER (11). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (Uli|
^t'TZGO
(a)
U3
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1S-OCT-91
PAGE: 16
ANIMAL NUMBER: C67536
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: S70.3 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 l:3S
PROSECTOR: RUTH SCHMITZ
RECORDER: JOE N KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU| LF. TESTIS (TEO) RT. TESTIS (TEI ACCESS/SEX 0RG (SO)
2.1616 11.4336
1.6590 1.1364 1.1160 3.0024
.3790 X 3.2323 X
.2909 X .3220 X .3307 X .5265 X
1.0000 I.S279
.7675 .1496 .1725 1.3190
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* ** PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG), LF . TESTIS (TEO). LIVER (LI), LUNG (LU|. PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA |UR)
jJfaTZGO
OJ 0o0
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6320-100 PRINTED: ll-OCT-01
PAGE: 17
ANIMAL NUMBER: C67537
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL BOOV WEIGHT: 3S0.6 GRAMS
DATE AND TIME OF NECROPSY: 01/24/01 0:00
PROSECTOR: KEVIN BILLINGS
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN IBR) LIVER (LI) LUNG (LU) LF. TESTIS (TE0| RT. TESTIS (TE1 | ACCESS/SEX ORG (SOI
1.0303 12.0515
1.4473 1.6041 1.6330 2.0150
.5360 X 3.5750 X
.4025 X .4461 X .4541 X .5605 X
1.0000 6.6614
.7400 .0310 .0460 1.0442
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * * PATHOLOGY' O B S E R V A T I O N S * * *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEY! S| (KD) ........................................ GROSS: -LARGE PELVIS(ESI MICRO: -PRESENT
......................... -RIGHT: BOTH COLLECTED -DILATATION.PELVIC
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR I. COAGULATING OLD ICG). LF. TESTIS ITEO). LIVER ILI I. LUNG (LU|, PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (URI
00214
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-OCT-B1
PAGE: IS
ANIMAL NUMBER: C67536
SEX. MALE
DOSE GROUP: 2
SACRIFICE STATUS. SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/16/91
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 692.6 GRAMS
DATE AND TIME OF NECROPSY: 05^16/91 6:37
PROSECTOR: GAIL M. NOVAK
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILAB
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO RT. TESTIS (TE1 ACCESS/SEX ORG SO)
2 2904 20 1606
1 9530 l .6505 1.7197 3.6643
3307 X 2.9137 X
.2620 X .2672 X .2463 X .5579 X
1.0000 6.6109
.6527 .6079 .7506 1.6672
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
N NAME
* * * PATHOLOGY' OBSERV AT I 0 N S *
KEYWORDS. SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI| ................................... MICRO: -SLIGHT. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR}. COAGULATING OLD (CO). LF. TESTIS (TEO), LUNG (LU). PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR I
GJ o" N
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE: 19
ANIMAL NUMBER: C67539
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDY DAY OF DEATH: 57
STUDY WEEK OF DEATH: 9
TERMINAL BOOY WEIGHT: 510.7 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 7:51
PROSECTOR: KEVIN BILLINGS
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI I LUNG (LU) LF. TESTIS (TEO) RT. TESTIS TE11 ACCESS/SEX C>RG (SOI
2.0356 17.4915
1.6069 1.7637 1.7937 3.3431
.3916 X 3.4264 X
.3146 X .3453 X .3512 X 6546 X
1.0000 1.5962
.7694 .6664 .1612 1.6423
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS *** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCJ .......................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ..................................................................................
MICRO: -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR). COAGULATING GLD (CG). LF . TESTIS (TEO). LUNG (LU). PROSTATE |PR). SEMINAL VESICLE |SV). URETHRA (UR)
fcTZQ!)
u0Ci0O
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-B1
PAGE: 90
ANIMAL NUMBER: C67540
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDY DAY OF DEATH: 55
STUDY WEEK OF DEATH: 9
TERMINAL OOY WEIGHT: 552.7 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 9:42
PROSECTOR: NANCY OIEDRICH
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (ORAMS)
OROAN WEIGHT RELATIVE TO 800Y WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR| LIVER jLX i LUNG (LU) LF. TESTlS JTEOl RT. TESTIS Itei ACCESS/SEX ()RG (SO)
2.1032 24.6735
1.1603 1.6493 1.6416 3.0235
.3905 X 4.4642 X
.3386 X .2994 X .2970 X .5470 X
1.0000 11.7314
.9945 .7942 .7905 1.4376
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
M O A N NAME
*** P A T H O L O G Y ' O B S E R V A T I O N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
MANDIB/CERV LN ( M N 1 .............................................................................................................
GROSS: -LARGE
-LEFT: UP TO 15 X 10 X 5 M (FOR COMPARISON RIGHT IS UP TO 9 X 3
X 2 MM| (CAP 61
MICRO: -MOOERATE, MULTI-FOCAL
-HYPERPLASIA. LYMPHORETICULAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR), COAGULATING GLO (CG). L F . TESTIS (TEO). LIVER (LI). LUNG ILUI. PROSTATE (PR|. SEMINAL VESICLE (SV). URETHRA (UR)
021
Ul
CD
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 91
ANIMAL NUMBER: C87541
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: U
TERMINAL BOOY WEIGHT: S 6 2 .1 GRAMS
DATE AND TIME OF NECROPSY. 03/22/91 9:42
PROSECTOR: KEVIN BILLINGS
RECORDER: JOE N KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT IGRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BRI LIVER (LIi LUNG (LU) LF. TESTIS (TEOI RT. TESTIS (TEI ACCESS/SEX ()RG (S0|
2.1370 18.4104
1 1520 1.5904 1.5680 3.7192
.3902 X 2.9319 X
.3295 X .2829 X .2718 X .8741 X
1.0000 7.7119
.9888 .7442 .7328 1.7731
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN N A M
* * * P A T H O L O G Y - O B S E R V A T I O N S *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR), COAGULATING OLD (CGI. LF. TESTIS (TEOI. LIVER (Lit, LUNG (LU|. PROSTATE (PR|, SEMINAL VESICLE (SV|, URETHRA |UR)
P
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 92
ANIMAL NUMBER: C67542
SEX: MALE
POSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH. 02/13/91
STUDY DAY OF DEATH: 58
STUDY WEEK OF DEATH: I
TERMINAL BODY WEIGHT: 432.9 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 1:13
PROSECTOR: RUTH SCHMITZ
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS 1
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR)
LIVER (LI)
LUNG (LU)
i
LF. TESTIS (TEO)
RT. TESTIS Itei
ACCESS/SEX (>RG (SO)
1.9704 14.674$
1.S792 1:6601 1.7024 2.2701
.4552 X 3.4591 X
.3641 X .3135 X .3933 X .5244 X
1.0000 7.5997
.1015 .1425 .1640 1.1521
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY' OBSERVATIONS
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR). COAGULATING GLD ICO). L F . TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
u> 0er0 h*
&
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 93
ANIMAL NUMBER: C67S43
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, FIRST POST-RECOV SAC
DATE OF DEATH: OS/16/91
STUDY DAY OF DEATH: 149
STUDY WEEK OF DEATH: 22
TERMINAL BOOY WEIGHT: S46.2 GRAMS
DATE AND TIME OF NECROPSY: OS/16/91 1:22
PROSECTOR: GAIL M. NOVAK
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT TESTIS (TE1 j ACCESS/SEX ORG (SO)
2.2021 16.9S93
1 7228 1.4962 1.5067 2.3164
.4033 X 3.1050 X
.3154 X .2739 X .2759 X .4389 X
1.0000 7.6990
.7120 .6792 .6940 1.0933
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * * P A T H O L O G Y - O B S E R V A T I O N S
KEYWORDS. SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC1 ......................... GROSS: -ALL TISSUES/ORANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR), COAGULATING OLD (CG). LF . TESTIS (TE0|, LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
r>
(0A0)
?0
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 94
ANIMAL NUMBER: C67544
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE DATE
OF DEATH AND TIME
01/25/91 OF N4ECROPSY:
STUDY 01/25/91
DAY OF 1:46
DEATH: 37
STUDY WEEK OF DEATH:
PROSECTOR: NANCY DIEDRICH
6
TERMINAL BOOY WEIGHT: 317.7 GRAMS RECORDER: JILL SEVAN
POST-FIX WEIGHER NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TEI ACCESS/SEX ()RG (SOI
2.0234 12.9162
1.4677 1.5412 1.6271 2.5267
.5219 X 3.3495 X
.3718 X .3975 X .4197 X .6517 X
1 0000 6 4110
.7254 .7617 .1041 1.2417
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOG KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL CO MENT : -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL, MULTI-FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG), IF TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
r> O0J0 CD
0
`V
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A
APPENOIX O INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-B1
PAGE: 95
ANIMAL NUMBER: C67S4S
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH. 02/14/91
STUDY DAY OF DEATH: 57
STUDY WEEK OF DEATH: 9
TERMINAL BODY WEIGHT. 436.6 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 7:37
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT 1GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS TEOI RT. TESTIS (TEl ACCESS/SEX ()Ag |S0)
2.0517 16 0053
1.5610 1.7131 1 11(4 3.1652
.4699 X 3.6659 X
.3575 X .4014 X .4165 X .7250 X
1.0000 7.1010
.7601 .(691 .((63 1.S427
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI
GROSS : -ALL TISSUES/ORGANS NORMAL
LUNG (LU| ........
GROSS :
NECROPSY NOTE: >TRIMMING COMMENT: ONE SECTION OF LIVER MISSING FROM WET TISSUE
AT TIME OF TRIMMING
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD |CG). L F . TESTIS (TEO|. LIVER (LI). LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA fuA)
r> Q
00(a)
IO
W
h*
in
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HUI 6329-100 PRINTED: H-OCT-91
PAGE: 96
ANIMAL NUMBER. C67S46
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH: 56
STUDY WEEK OF DEATH: I
TERMINAL BODY WEIGHT: 476.9 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 9:03
PROSECTOR: RUTH SCHMITZ
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: TILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER |LI I LUNG (LU) LF TESTIS ITEOI RT. TESTIS Itei ACCESS/SEX ()RG (SO)
2.1157 16.1950
1.5315 1.6199 1.6997 2.7094
.4436 X 3.3959 X
.3226 X .3541 X .3541 X .5679 X
1.0000 7.6547
.7272 .7992 .7992 1.2901
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COfWENT IOC) OROSS: -ALL TISSUES/ORQANS NORMAL
LIVER (LI) MICRO: -MINIMAL, FOCAL..........
INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBM). COAGULATING GLO |CG), LF . TESTIS (TEO). LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
UUo>)
N P
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED. 1S-OCT-91
PAGE: 97
ANIMAL NUMBER: C67547
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDY DAY OF DEATH: 57
STUDY WEEK OF DEATH: 9
TERMINAL BOOY WEIGHT: 464.1 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 1:59
PROSECTOR: KEVIN BILLINOS
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS 1
ORGAN WEIGHT RELATIVE TO BODY WEIGHT |X|
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS m o i RT. TESTIS (TEH ACCESS/SEX ORG (SOI
2.1074 15.3574
1.6511 1.5711 1.6541 2.5313
.4534 X 3.3041 X
.3554 X .3397 X .3560 X .5446 X
1.0000 7.2174
.7131 .7492 .7152 1.2011
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLO 0 Y OSSERVATI 0 N S *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI . . GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR1. COAGULATING; GLD (CGI. LF. TESTIS (TEO)., LIVER (LI). LUNG (LU), PROSTATE (PR). SEMINAL VESICLE |SV|. URETHRA (UR)
f 0215
ui
ID
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-Ol
PAGE: 9
ANIMAL NUMBER: C67S4I
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, FIRST POST-RECOV SAC
DATE OF DEATH: 05/17/91
STUDY DAY OF DEATH: 149
STUDY WEEK OF DEATH: 22
TERMINAL BOOT WEIGHT: 560.7 GRAMS
OATE AND TIME OF NECROPSY: 05/17/91 7:09
PROSECTOR: DEBBIE PIRKEL
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR | LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1I ACCESS/SEX ORG (SO)
2.2282 17 9114
1.5154 1.7379 1.7066 3.5671
.3970 X 3.2012 X
.2703 X .3100 X .3044 X .6363 X
1.0000 1.0103
.6107 .7107 .7666 1.6026
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOG KEYWORDS. SEVERITY. DISTRIBUTION
B S E R V A T IO N S * GROSS FREE- TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC)
GROSS : -ALL TISSUES/ORGANS NORMAL
LUNG (LU| ..........
GROSS:
NECROPSY NOTE: >TRIM4INQ C O W E N T : MISSING FROM WET TISSUE AT TIME OF TRIMMING
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|. COAGULATING GLD (CG). L F . TESTIS (TEO). LIVER (LI). LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
OtrvJ>>
U\
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 99
ANIMAL NUMBER: C67549
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/25/91
STUOV DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 609.5 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 9:12
PROSECTOR: JACK SERFORT
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (Llj LUNG 1LU| LF. TESTIS (TEO) RT TESTIS Itei j ACCESS/SEX ()RG (SO)
2.2803 23.4192
1.7373 1.1229 1.1225 3.9714
.3701 X 3.1424 X
.2150 X .2991 X .2990 X .6516 X
1.0000 10.3611
.7666 .1065 .1063 1.7570
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
*** P A T H O L O G Y ' O B S E R V A T I O N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) .......................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ..................................................................................
MICRO. -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD ICQ), LF . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
o n
t/I c>
itjoj
(a )
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: li-OCT-91
PAGE: 100
ANIMAL NUMBER: C675SO
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 317.9 GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 1:10
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT 1GRAMS 1
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
1.9197 14 1445
1.5451 1.5024 1.4136 2.5265
.5129 X 3.6464 X
.3913 X .3173 X .3125 X .6513 X
1.0000 7.1019
.7765 .7551 .7456 1.2691
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y ' O B S E R V A T I O N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING OLD (CGI, L F . TESTIS (TEO). LIVER (LI). LUNG (LU|, PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
u>
to
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 0329-100 PRINTED: ll-OCT-91
PAGE. 101
ANIMAL NUMBER: CS7SS1
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/25/91
STUDY DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL BOOY WEIGHT: 513.4 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 10:09
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN IBR) LIVER (LI) LUNG (LU) LF. TESTIS (TEOI RT TESTIS 1TE11 ACCESS/SEX ORG (SO)
2.3262 17 3152
1 5754 1.7933 1 *257 4.3740
.3997 X 2.9900 X
.2700 X .3074 X .3129 X .7497 X
1.0000 7.4736
.6772 .7709 .7949 1.9*03
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * * P A T H O L O G Y ' O B S E R V A T I O N S **
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR J, COAGULATING GLD (CG), L F . TESTIS (TEO), LIVER (LIJ. LUNG (LU). PROSTATE (PR ). SEMINAL VESICLE |SV), URETHRA |UR)
C021S
u> IwO
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTEO: 18-OCT-91
PAGE: 102
ANIMAL NUMBER: C67552
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH. 03/26/91
STUOY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL BOOV WEIGHT: 610.2 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 9:01
PROSECTOR: STEVE VAN AOESTINE
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIQHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR1 LIVER (LI) LUNG (LU| LF. TESTIS (TEO) RT TESTIS (TE1I ACCESS/SEX ORG SO)
2.0215 23.6634
1.1710 2.0116 2.5660 3.6105
.3313 X 3.9106 X
.1919 X .3411 X .4236 X .6245 X
1.0000 11.1048
.5793 1.0297 1 2792 1.6850
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) GROSS : -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO. -SLIGHT. FOCAL
-NECROSIS, COAGULA U V E
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR). COAGULATING GLD (CO). L F . TESTIS (TEO), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
O
Q
U> VoO>
M
(f)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6320-100 PRINTED: ll-OCT-Bl
PAGE: 103
ANIMAL NUMBER: C67SS3
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/25/01
STUDY DAY OF DEATH: 00
STUDY WEEK OF DEATH: 14
TERMINAL BOOY WEIGHT: 560.6 GRAMS
OATE AND TIME OF NECROPSY: 03/25/01 0:30
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: OR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BRI LIVER (LI) LUNO (LU) LF TESTIS (T0I RT TESTIS TEI ACCESS/SEX ORQ (SO)
2.1217 17.9913
1.771# 1.7765 1.7760 3.5994
.3715 X 3.2093 X
.3161 X .3169 X .3169 X .6421 X
1.0000 6.4797
.1351 .6373 .1371 1.6965
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
*** P A T H O L O G Y . O B S E R V A T I O N S *
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC I ........................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI| ..................................................................................
MICRO: -MINIMAL, FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CGI. L F . TESTIS (TEO), LUNG (LU|, PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA |UR|
9T200
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 104
ANIMAL NUMBER: C87554
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, SECONO INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH: 56
STUDY WEEK OF DEATH: I
TERMINAL 00V WEIGHT: 496.4 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 7:45
PROSECTOR: DENNIS HOFFMAN
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT |X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI I LUNG (LU) LF. TESTIS (TEOI RT. TESTIS (TE1 ACCESS/SEX ()RG (SO)
2 1661 19.4011
1 6152 1.7070 1.6770 3.5907
.4365 X 3.9096 X
.3254 X .3439 X .3378 X .7233 X
1 0000 6.9570
.7454 .7878 .7740 1.6571
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
*** P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
GENERAL COMMENT GCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBM). COAGULATING OLD ICO). L F . TESTIS (TEO), LIVER |L1), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA |UR)
fSTSOO
CO
K0O0
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1S-OCT-01
PAGE: 105
ANIMAL NUMBER: C67S55
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUDY DAY OF DEATH: 35
STUDY WEEK OF DEATH. 5
TERMINAL BODY WEIGHT: 422.1 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 1:01
PROSECTOR: NANCY DIEDRICH
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR| LIVER (LI) LUNG (LU) LF. TESTIS ITEO I RT. TESTIS Itei ACCESS/SEX ()RG (SO)
2.0072 15.7692
1.5776 1.4911 1 4914 2.7610
.4755 X 3.7406 X
.3731 X .3549 X .3533 X .6541 X
1.0000 7.1663
.7160 .7464 .7430 1.3755
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * PATHOLOGY- O B S E R V A T I O N S * *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEY(S) (KD) .......................................... ....................................
GROSS: -LARGE PELVIS(ES)
-RIGHT: BOTH KIDNEYS COLLECTED
MICRO: -PRESENT
-DILATATION.PELVIC
LIVER (LI| ..................................................................................
MICRO: -SLIGHT, FOCAL
-INFILTRATES,MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING GLD (CG). L F . TESTIS (TEO), LUNG |LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR|
^9T200
<uA>>
IO
HA2LETON LABORATORIES AMERICA, INC. MAOISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 106
ANIMAL NUMBER: C67SS6
SEX. MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 532.3 GRAMS
DATE AND TIME OF NECROPSY. 03/28/91 1:35
PROSECTOR: STEVE VAN ADESTINE
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER. JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR1 LIVER (LI) LUNG ILUI LF. TESTIS ITEOl RT. TESTIS (TE1 ACCESS/SEX ORG (SO)
2.2605 16.9166
1.4190 1.5240 1.5304 3.7276
.4247 X 3.1760 X
.2666 X .2863 X .2875 X .7003 X
1.0000 7.4836
.6277 .6742 .6770 1.6490
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L O G Y - O S S E R V A T I 0 N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCl . . GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR1. COAGULATINC OLD (CG). LF. TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 329-100 PRINTED: lt-OCT-91
PAGE: 107
ANIMAL NUMBER. C67557
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUOY DAY OF DEATH: 57
STUDY WEEK OF DEATH: 9
TERMINAL BODY WEIGHT: 50S.0 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 7.29
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORQ A N STA TU S
BRAIN (BR) LIVER |LI$ LUNG (LU) LF. TESTIS (TEO) RT. TESTIS jTE1) ACCESS/SEX ORQ (SO)
2.1055 17.0301
1.7292 1.7949 1.9211 3.6050
.4169 X 3.3723 X
.3424 X .3534 X .3606 X .713 X
1.0000 9.0994
.9213 .947 .9649 1.7122
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WE IGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
O B S E R V A T I o NS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI . . GROSS: -ALL TISSES/RGANS NORMAL
LIVER ILI 1 ............ MICRO: -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATINGi GLO (CG). LF. TESTIS (TEOI. LUNG (LU), PROSTATE (PR) . SEMINAL VESICLE |SV). u r e t h r a IUR)
<9TZi>
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED. ll-OCT-91
PAGE: 109
ANIMAL NUMBER: C67556
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/01
STUDY DAY OF DEATH. 35
STUDY WEEK OF DEATH: 5
TERMINAL BODY WEIGHT: 433.7 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 1:20
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORG A N STA t U S
BRAIN (BR) LIVER jLIj LUNG (LU) LF. TESTIS 1TE0) RT. TESTIS (TEll ACCESS/SEX ORG (SO)
2.1439 17 5518
1 6351 1.6699 1.6140 2.6345
.4943 X 4.0416 X
.3772 X .3650 X .3721 X .6074 X
1.0000 1.1900
.7630 .7719 .7521 1.2211
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * * P A T H O L O G Y' O B S E R V A T I O N S *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC1 GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL, FOCAL
-INFLAMMATION.GRANULOMATOUS
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR) . COAGULATING1 OLD (CG). LF. TESTIS (TEO), LUNG (LU). PROSTATE (PR) . SEMINAL VESICLE (SV). URETHRA (UR)
00216
No
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1S-0CT-91
PAGE: 109
ANIMAL NUMBER: C67559
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 111.4 GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 7:51
PROSECTOR: DENNIS HOFFMAN
RECORDER: NANCY DIEDRICH
POST-FIX WEIGHER. NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR) LIVER (LI 1 LUNG (LU) LF. TESTIS (TEO) RT TESTIS jTE11 ACCESS/SEX ORG (SO)
2 0513 19 2277
1 .6191 1.5713 1.5797 3 5514
.4200 X 3.7321 X
.3313 X .3232 X .3234 X .7216 X
1.0000
9.. 79999599
.7694 .7701 1.7347
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y 1" O B S E R V A T I O N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCJ ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BRJ. COAGULATING OLD (CG|. LF . TESTIS (TE01. LIVER (LI|, LUNG (LU). PROSTATE (PR). SEMINAL VESICLE |SV). URETHRA |UR)
G0216
ow
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTEO: ll-OCT-Ol
PAGE: 110
ANIMAL NUMBER: C67S60
SEX: MALE
DOSE GROUP: 2
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUOY DAY OF DEATH. $S
STUDY WEEK OF DEATH: I
TERMINAL BODY WEIGHT: 472.1 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 1:22
PROSECTOR: RUTH SCHMITZ
RECOROER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEOI RT. TESTIS ITE11 ACCESS/SEX ORO (SO)
2.0403 17 4734
1.5154 1.5902 1.5396 3.6606
.4322 X 3.7012 X
.3356 X .3366 X .3261 X .7796 X
1.0000 6.5641
.7770 .7794 .7546 1.6040
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY* OBSERVATIONS
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING GLD (CGI, L F . TESTIS (TEO). LIVER (LI ). LUNG (LU ). PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR)
o
N
P
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 111
ANIMAL NUMBER: C6T561
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/17/91
STUDY DAY OF DEATH: 149
STUDY WEEK OF DEATH: 22
TERMINAL BOOY WEIGHT: 612.1 GRAMS
DATE AND TIME OF NECROPSY. OS/17/91 1:09
PROSECTOR: DEBBIE PIRKEL
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER jLI) LUNG |LU) LF TESTIS (TEO ]I RT TESTIS (TE1 1 ACCESS/SEX ORG |[SO)
2 2294 11.9096
1.5153 1 3121 1.6140 4.2129
.3631 X 3.0151 X
.2517 X .2142 X .2741 X .6175 X
1 0000 (.4119
.7111 .5119 7554 1.1197
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY- OSSERVATI 0 N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC1 ....................................
GROSS. -ALL TISSUES/ORGANS NORMAL
LF, TESTIS ITEO) ....................................................................
MICRO: -MODERATE. MULTI-FOCAL
-ATROPHY/DEGENCRATION
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG), LIVER (LI|. LUNG (LU|, PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
TZOO
oin
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 16-OCT-91
PAGE: 112
ANIMAL NUMBER: C67562
SEX: MALE
DOSE GROUP. 3
SACRIFICE STATUS. SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 433.1 GRAMS
DATE ANO TIME OF NECROPSY: 01/25/91 >:2t
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL BEVAN
POST-FIX WEIGHER. NOT AVAILABLE
PATHOLOGIST: DR TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS|
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER |LI) LUNG |LU) LF. TESTIS (TEO) RT. TESTIS (te i i ACCESS/SEX (JRG (SO)
2.0610 19.3161
1 4976 1 7701 1.7361 3 1276
.4751 X 4.4660 X
.3452 X .4060 X .4002 X .7210 X
1.0000 9.4062
.7266 .6569 .6424 1.5178
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
*** p a t h o l o g y ' OBSERVATIONS
KEYWORDS. SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER ILI) .................................... MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR THIS "ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL"
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD |CG), L F . TESTIS |TE0). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
f.TZOQ
oo>
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1S-OCT-91
PAGE: 113
ANIMAL NUMBER: C67563
SEX: MALE
DOSE GROUP 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 631.7 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 6:01
PROSECTOR: KEVIN BILLINGS
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER jLI| LUNG (LU) LF. TESTIS ITEO]1 RT. TESTIS ITElj ACCESS/SEX ORO ISO)
2.1397 26.7202
1.I60S 1.6004 1.7096 3.6660
.3367 X 4.2299 X
.2946 X .2650 X .2706 X .6123 X
1.0000 12.4676
.6697 .6414 .7990 1.6077
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY ' OSSERVATI 0 N S **
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCj GROS!>: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTR1L08ULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP' APPEARANCE. EXCEPT FOR THIS 'ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). L F . TESTIS (TEOJ. LUNG 1LU|. PROSTATE (PR), SEMINAL VESICLE (SV|. URETHRA (UR)
G027JL
o''j
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1S-OCT-B1
PAGE: 114
ANIMAL NUMBER: C67564
SEX: HALE
DOSE GROUP. 3
SACRIFICE STATUS SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/25/91
STUDY DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL BOOY WEIGHT: 569.9 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 9:14
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST. DR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR)
LIVER (LI)
LUNG ILU]
LF TESTIS (TEO
RT. TESTIS ACCESS/SEX
OR(GTEI
SO)
2.1277 20.0061
1.5691 1.6240 1.7241 3.9433
.3733 X 3.5105 X
.2755 X .3201 X .3025 X .8919 X
1.0000 9.4027
.7376 .6573 .6103 1.6533
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWOROS, SEVERITY, DISTRIBUTION
OBSERVATI 0 NS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (OC I GROS:i: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL, MULTI-FOCAL -MINIMAL
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRIL08ULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BOROERS ARE MORE ROUNDED GIVING THE CELLS A MORE `PLUMP" APPEARANCE. EXCEPT FOR
THIS `ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL'
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG|, L F . TESTIS (TEO), LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
gT20D
o00
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 19-OCT-91
PAGE: U S
ANIMAL NUMBER: C67S6S
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUOY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 6
TERMINAL OOY WEIGHT: 390.4 GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 1:59
PROSECTOR: NANCY DIEORICH
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN LIVER LUNG
(L|(ULB)IRj1I
LF. TESTIS ITEOI
RT. TESTIS CTCI 1
ACCESS/SEX ORO (SO)
1.9776 16 3602
1.4164 1.5171 1.5533 2.2069
.5066 X 4.1906 X
.3107 X .3669 X .3979 X .5653 X
1.0000 9.2721
.7516 .7875 .7954 1.1159
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * PATHOLOG KEYWORDS. SEVERITY. DISTRIBUTION
BSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT 1GC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ................................... MICRO: -MINIMAL, FOCAL -MINIMAL
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCVTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP" APPEARANCE EXCEPT FOR
THIS 'ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). LF . TESTIS (TEO|. LUNG (LU|. PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
#TZOO
Io
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE. 116
ANIMAL NUMBER: C67566
SEX: MALE
DOSE GROUP. 3
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUOY WEEK OF DEATH: 6
TERMINAL BOOY WEIGHT: 421.7 GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 9.-14
PROSECTOR: KEVIN BILLINGS
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT 1GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO]1 RT. TESTIS (TE1|1 ACCESS/SEX ORG jISO)
2.1092 19.6931
1.4756 1.7064 1.7142 2.6099
.5002 X 4.6701 X
.3499 X .4051 X .4065 X .6119 X
1.0000 9.3371
.6996 .6100 .6127 1 2374
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOGY ' OBSERVATI 0 NS **
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC1 GROSS : -ALL TISSUES/ORGANS NORMAL
LIVER ILI) MICRO: -MINIMAL. MULTI-FOCAL -MINIMAL
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BOROERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR THIS 'ENLARGED' APPEARANCE, THE CELLS ARE OTHERWISE `NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). L F . TESTIS |TE0). LUNG |LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
O
N
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 19-OCT-91
PAGE: 117
ANIMAL NUMBER: C67S67
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/16/91
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 22
TERMINAL BOOT WEIGHT: 640.3 GRAMS
DATE AND TIME OF NECROPSY: 05/16/91 9:09
PROSECTOR: DEBBIE PIRKEL
RECORDER: JOE N. KIZ2IEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN fBR1 LIVER jLIi LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2.3313 11.9256
1.6877 1.7147 1.9164 3.2990
.3641 X 2.9557 X
.2605 X .2797 X .2937 X .5135 X
1.0000 9.1190
.7154 .7655 .7791 1.4104
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY' O B S E R V A T I O N S *
KEYWORDS, SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ................................... MICRO: -MINIMAL, FOCAL
-INFILTRATES,MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BRI, COAGULATING OLD (CG|, LF . TESTIS (TEO), LUNG (LU|, PROSTATE
(PR I. SEMINAL
VESICLE
(SV|, URETHRA
(UR|
qTzoo
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX O INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: U S
ANIMAL NUMBER: C67S6S
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY OAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 397.0 GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 7:55
PROSECTOR: KEVIN BILLINGS
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TEI ACCESS/SEX (JRG (SO)
1.9901 17.9401
1.3967 1.5139 1.5234 2.9710
.4999 X 4.5199 X
.3493 X .3913 X .3937 X .7494 X
1.0000 0.0602
.7003 .7645 .7694 1.S004
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT oiosl: -ALL TISSES/RGANS NORMAL
LIVER (LI) MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTR1LOBULATED PATTERN IN WHICH THE HEPATOCVTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR THIS "ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD ICO). LF . TESTIS (TEO). LUNG |LU|. PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
TZG3
ro
HA2LET0N LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 119
ANIMAL NUMBER: C67S69
SEX: MALE
DOSE GROUP. 3
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL OOY WEIGHT: 319.1 GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 7:29
PROSECTOR: JULIE A. LARSEN
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORG A N S TA TU S
BRAIN (BR| LIVER |LI) LUNG (LU| IF. TESTIS m o i RT. TESTIS (TEI 1 ACCESS/SEX ORG (SO)
2.0620 16.0001
1.3330 1.7269 1.7674 2.6631
.5290 X 4.1049 X
.3420 X .4430 X .4534 X .6134 X
1.0000 7.7591
.6465 .6375 .1571 1.2919
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T M 0 L 0 G Y O B S E R V A T 1 0 NS *
KEYWORDS. SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT ICI GROSS : ALL T1SSUES/0RQANS NORMAL
LIVER (LI I MICRO: -MINIMAL. FOCAL
-INFLAMMATION.ORANULOMATOUS
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR| . COAGULATING1 OLD (CG|. LF. TESTIS (TEO) . LUNG (LU|. PROSTATE (PR) , SEMINAL VESICLE |SV). URETHRA (UR|
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PACE: 120
ANIMAL NUMBER: C67S70
SEX: MALE
DOSE CROUP: 3
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF OEATH: 02/14/91
STUOY DAY OF DEATH: S7
STUDY WEEK OF OEATH: 9
TERMINAL BODY WEIGHT 442.7 CRAMS
DATE AND TIME OF NECROPSY: 02/14/91 7:40
PROSECTOR: RUTH SCHMITZ
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG 1LUI LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2.2465 1IOI79
1.4029 1.1392 1.7192 3.9661
.5079 X 4.0656 X
.3169 X .4155 X .4042 X .6959 X
1.0000 6.0444
.6239 .6160 .7957 1.7639
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * PATHOLOG KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ............ GROSS: -MALOCCLUSION
LIVER |LI) ....................... MICRO. -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR THIS "ENLARGED" APPEARANCE, THE CELLS ARE OTHERWISE "NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CO). L F . TESTIS |TE0), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
n
o
go
HA2LETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE. 121
ANIMAL NUMBER. C67ST1
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL ODY WEIGHT: 491.6 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 7:41
PROSECTOR: RUTH SCHMITZ
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BRIl
LIVER jLI 11 LUNG (LU)
,
LF TESTIS (TEO)
RT TESTIS (TEI I
ACCESS/SEX ORG (SOI
2.12S5 17.3730
1.4239 1 9603 1.9607 4.2992
.4324 X 3.5340 X
.2996 X .3999 X .3795 X .9745 X
1 0000 9.1736
.6699 .9223 .9754 2.0227
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATI 0 N S GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI I .................................... MICRO: -MINIMAL. FOCAL -MINIMAL
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNOEO GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR THIS "ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING GLD (CG|. LF . TESTIS (TEO). LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV), URETHRA (UR)
GO21S0
on
HAZLETON LABORATORIES AMERICA. INC. MAOISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED. U-OCT-91
PAGE. 122
ANIMAL NUMBER: C67S72
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/17/91
STUDY DAY OF DEATH: 149
STUDY WEEK OF DEATH: 22
TERMINAL BOOY WEIGHT: SS3.3 GRAMS
DATE AND TIME OF NECROPSY: 05/17/91 7:11
PROSECTOR: DEBBIE PIRKEL
RECORDER: JOE N. K12ZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG 1LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2.2251 11.4045
1.7515 1.6419 1.5651 3.3023
.4022 X 3.3283 X
.3168 X .2910 X .2929 X .5961 X
1.0000 1.2713
.7172 .7410 .7034 1.4141
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOG KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC)
GROSS: -ALL TISSUES/ORGANS NORMAL
LUNG (LU) ........
GROSS:
NECROPSY NOTE:
>TRIMMING COMMENT: TWO LEFT LOBES OF LUNG FOUND IN WET TISSUE: BOTH PROCESSED. ONE IN BLOCK 2, AND ONE IN BLOCK 16
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR), COAGULATING OLD ICG). LF . TESTIS (TEO), LIVER (LI). LUNG (LU). PROSTATE (PR), SEMINAL VESICLE (SV|. URETHRA (UR)
6
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE: 123
ANIMAL NUMBER. C67573
SEX: HALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/17/91
STUDY DAY OF DEATH: 149
STUDY WEEK OF OEATH. 22
TERMINAL BODY WEIGHT: 526.7 GRAMS
DA7E AND TIME OF NECROPSY: 05/17/91 7:40
PROSECTOR: DEBBIE PIRKEL
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |8R) LIVER (LIf LUNG (LU) LF TESTIS (TEO) RT. TESTIS (TEI 1 ACCESS/SEX ()RG (SO)
2 1454 14.1221
1 5733 1 7071 1 7022 3.6631
.4073 t 2.6114 X
.2917 X .3241 X .3232 X .8955 X
1.0000 6.5926
.7333 .7957 .7934 1.7074
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOGY' O B S E R V A T I O N S
KEYWORDS, SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
BRAIN (SRI .............................................. .................................................................
GROSS:
NECROPSY NOTE: TRIMMING COMMENT: MISSING FROM WET TISSUE AT TIME OF TRIMMING
MICRO: -TISSUE MISSING
GENERAL COMMENT (OC) ...................................................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: COAGULATING GLD (CG). L F . TESTIS (TEO). LIVER (LI), LUNG (LU). PROSTATE (PR), SEMINAL VESICLE (SV|, URETHRA (UR)
021
HAZLETON LABORATORIES AMERICA. INC. MAOISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE. 124
ANIMAL NUMBER: C9T574
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS. SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH: 37
STUDY WEEK OF DEATH. 6
TERMINAL ODY WEIGHT: 396.9 GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 9:22
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR| LIVER (LI) LUNG |LU) LF. TESTIS (TEO RT TESTIS (TEI ACCESS/SEX ()RG (SO)
2.0001 16.1510
1.4023 1.1672 1 1099 3.4002
.5042 X 4.0703 X
.3534 X .4706 X .4561 X .9589 X
1.0000 1.0723
.7009 .9332 .9046 1.6994
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC I .................................. ....................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ...........................................................................................................
MICRO: -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
-MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR
THIS "ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). LF . TESTIS (TEO). LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
C021SJ'
00
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-B1
PAGE: 12S
ANIMAL NUMBER: C67S7S
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/16/91
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 22
TERMINAL ODV WEIGHT: 729.2 GRAMS
DATE AND TIME OF NECROPSY 05^16/91 7:14
PROSECTOR: DEBBIE PIRKEL
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVA1LAB
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOT WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
0RGAN S TA TU S
BRAIN IBRI LIVER (LI) LUNG (LU) LF. TE STIS (TEOI RT. TESTIS tei ACCESS/SEX ORQ (SO)
2 2754 22 2539
1.7949 2.0331 2.0447 3.4670
.3120 X 3.0511 X
.2461 X .2769 X .2104 X .4755 X
1 0000 9.7102
.7116 .6936 .6966 1.5237
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L O G V' KEYWORDS. SEVERITY. DISTRIBUTION
BSER VA T IONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER |LI) ................................... MICRO: -SLIGHT. FOCAL
-NECROSIS.COAGULATIVE
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG|. L F . TESTIS (TEOI. LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
ySTZOO
sO
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329*100 PRINTED: II-OCT-91
PAGE: 126
ANIMAL NUMBER: C67576
SEX: HALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUDY DAY OF DEATH: 35
STUDY WEEK OF DEATH: 5
TERMINAL BODY WEIGHT: 317.9 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 1:25
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT TESTIS (TEI ACCESS/SEX 0iRG (SO)
1.1902 17.4704
1.3139 1 6117 1.6220 3.lilt
.4173 X 4.503 X
.3317 X .4173 X .4111 X .1221 X
1.0000 0.2426
.6951 .1564 .1511 1.6170
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOG KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVA T IO N S * GROSS FREE- TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) GROSS ALL TISSUES/ORGANS NORMAL
LIVER |LI ) . . . MICRO. -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTR1LOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP" APPEARANCE. EXCEPT FOR THIS 'ENLARGED' APPEARANCE, THE CELLS ARE OTHERWISE "NORMAL'
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR|. COAGULATING OLD (CQ). LF . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
^STOi}
MO
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 127
ANIMAL NUMBER: C6T577
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUDY DAY OF DEATH: 35
STUDY WEEK OF DEATH: 5
TERMINAL BODY WEIGHT: 363.6 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 9:46
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT 1GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR|1 LIVER (LI I1 LUNG (LU) LF TESTIS (TEO) RT. TESTIS (TEI) ACCESS/SEX ORG (SO)
2.0559 16.0941
1 2149 1.5117 1.6657 2.3630
.5654 X 4.4265 X
.3534 X .4350 X .4511 X .6499 X
1.0000 7.6216
.6250 .7693 .6102 1.1494
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT 1GC) GROSS : -ALL TISSUES/ORGANS NORMAL
LIVER ILI) MICRO: -MINIMAL
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP' APPEARANCE EXCEPT FOR THIS 'ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL'.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING GLD (CG). L F . TESTIS (TEO), LUNG (LU). PROSTATE |PR). SEMINAL VESICLE ISV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC MADISON, WISCONSIN U S A
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-OCT-91
PAGE: 121
ANIMAL NUMBER: C6757I
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS. SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDY DAY OF DEATH: 55
STUDY WEEK OF DEATH: I
TERMINAL BOOY WEIGHT: 466.6 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 9:38
PROSECTOR: RUTH SCHMITZ
RECORDER. DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (Lit LUNG (LU) LF TESTIS ITEO) RT. TESTIS (TEI ACCESS/SEX ()RG (S0|
2.0477 17.5462
1.5091 1.7745 1.6667 3.2620
.4399 X 3 7604 X
.3236 X .3103 X .3572 X 6991 X
1.0000 t .5617
7373 .1666 .1139 1 5930
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI GROSS:
LUNG |LU) GROSS MICRO
......................... -ALL TISSUES/ORGANS NORMAL
NECROPSY NOTE: -TISSUE MISSING
TRIMMING COMMENT: OF TRIMMING
LUNG SECTION MISSING FROM WET TISSUE AT
TIME
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|. COAGULATING GLD (CO), L F . TESTIS (TEO), LIVER (LI). PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
STZOO
rMs>
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: H-OCT-91
PAGE: 129
ANIMAL NUMBER. C67ST9
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, FIRST POST-RECOV SAC
DATE OF DEATH: 05/16/91
STUOY DAY OF DEATH. 141
STUDY WEEK OF DEATH. 22
TERMINAL BODY WEIGHT: 5(7.0 GRAMS
DATE AND TIME OF NECROPSY: 05/16/91 1:33
PROSECTOR: DEBBIE PIRKEL
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER. NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR)
LIVER (LI) LUNG (LU)
'
LF TESTIS (TEOI
RT. TESTIS TEI
ACCESS/SEX ORG (SO)
2 1446 11.39(0
1.6293 1.7570 1 7759 3.(273
.3653 X 3.1342 X
.2776 * .2993 X .3025 X .6520 X
1.0000 (57((
.7597 (193 (211 1.7(46
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWOROS. SEVERITY. DISTRIBUTION
OBSERVATIONS ** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ........................................................................
GROSS: -ALL TISSUES/ORQANS NORMAL
LIVER (LX) ..................................................................................
MICRO. -SLIGHT. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). LF. TESTIS (TEOI. LUNG |LU|. PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6320-100 PRINTED : ll-OCT-91
PAGE: 130
ANIMAL NUMBER. C67S90
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH: 56
STUDY WEEK OF DEATH: I
TERMINAL BODY WEIGHT. 441.B GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 9:11
PROSECTOR: DENNIS HOFFMAN
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF . TESTIS (TEO RT. TESTIS TE1 ACCESS/SEX ()RG |SO|
2.0926 19.3210
1.5312 1 OS 39 1.5651 3.6104
.4714 X 4.3732 X
.3466 X .2315 X .3543 X .9330 X
1.0000 9.2773
.7352 .5061 .7515 1.7672
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * * P A T H O L O G Y ' O B S E R V A T I O N S **
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LF. TESTIS (TEOJ ........................................ ...........................................................
GROSS: -SMALL
-10 X 11 X 20 MM (FOR COMPARISON RIGHT IS 10 X 13 X 211; SOFT
MICRO: -MOOERATELY SEVERE. DIFFUSE
-ATROPHY/OEGENERATION
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG|, LIVER (LI|. LUNG (LU|, PROSTATE (PR), SEMINAL VESICLE (SV), URETHRA (UR 1
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329*100 PRINTED: 16-OCT-91
PAGE: 131
ANIMAL NUMBER: C675S1
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH: 56
STUDY WEEK OF DEATH: I
TERMINAL OOY WEIGHT: 463.1 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 9:30
PROSECTOR: RUTH SCHMITZ
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF TESTIS (TEO) RT. TESTIS jTE1{ ACCESS/SEX ORG (SO)
1.9335 11 5770
1.7077 1.7079 1.6913 3.4546
.3996 X 3.1396 X
.3530 X .3530 X .3510 X .7141 X
1.0000 9.6060
.6632 .6633 .6764 1.7667
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O Q KEYWOROS. SEVERITY. DISTRIBUTION
BSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT |GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ................................... MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE `PLUMP' APPEARANCE. EXCEPT FOR THIS `ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL" .
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR). COAGULATING GLD ICG), LF . TESTIS (TEO), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
Q6TZ0)
rcon
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 132
ANIMAL NUMBER: C87562
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH: 56
STUDY WEEK OF DEATH: t
TERMINAL BODY WEIGHT: 457.3 GRAMS
DATE AND TIME OF NECROPSY 02^13/91 1:36
PROSECTOR: DENNIS HOFFMAN
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILAB
PATHOLOGIST: JULIE A. LARSEN
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN fBR1 LIVER iLI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS jTE1 ) ACCESS/SEX 0|RG (SO)
2.1754 22 3152
1.5590 1 5470 1 5773 3.1744
.4757 X 4.1791 X
.3409 X .3313 X .3449 X .6942 X
1.0000 10.2560
.7168 .7111 .1251 1.4592
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * PATHOLOGY' OBSERVATI 0 N S * *
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER |LI) ................................... MICRO: -SLIGHT. FOCAL -MINIMAL
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BOROERS ARE MORE ROUNOEO GIVING THE CELLS A MORE 'PLUMP' APPEARANCE. EXCEPT FOR
THIS 'ENLARGED' APPEARANCE, THE CELLS ARE OTHERWISE 'NORMAL'.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR). COAGULATING GLD (CG|, L F . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
|6T209
roiy
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 18-OCT-91
PAGE: 133
ANIMAL NUMBER C67583
SEX MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
OATE OF DEATH: 02/12/91
STUOY DAY OF DEATH: S5
STUDY WEEK OF DEATH: 1
TERMINAL BODY WEIGHT: 453 I GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 8:10
PROSECTOR: KEVIN BILLINGS
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (ORAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO 8RAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS TEO RT. TESTIS (TEl ACCESS/SEX <)RG (SO)
2.0247 11 8334
1.4038 1 4218 1.4119 3.5708
.4462 X 4.1502 X
.3093 X .3133 X .3111 X .7869 X
1.0000 9.3018
.6932 .7022 .6973 1.7636
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) .................................. .............................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ................................................................................................................
MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZEO BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR
THIS 'ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL'.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR), COAGULATING OLD (CG). L F . TESTIS (TEO). LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
tfSTZOO
rNoJ
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE. 134
ANIMAL NUMBER. C6T5I4
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. SECONO INTERIM SACRIFICE
DATE OF DEATH. 02/12/91
STUDY DAY OF DEATH: 55
STUDY WEEK OF DEATH: (
TERMINAL BOOY WEIGHT: 497.1 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 9:46
PROSECTOR: RUTH SCHMITZ
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF TESTIS ITEO]1 RT. TESTIS TE1 ACCESS/SEX ORO {[SO)
2 0062 24.1724
1.6070 2 0352 1.9161 3.5310
.4036 X 4.1627 X
.3635 X .4094 X .3155 X .7103 X
1 0000 12.0499
.9007 1.0145
.9551 1.7600
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
*** PATHOLOGY KEYWOROS. SEVERITY. DISTRIBUTION
OBSERVATI 0 N S * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT LIVER (LI )
LUNG (LU)
(QCI GROSS: MICRO:
GROSS. MICRO:
......................... -ALL TISSUES/ORGANS NORMAL -MINIMAL
-TISSUE MISSING
NECROPSY NOTE:
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED c e n t r i l o b u l A t e d PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR THIS "ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL" . TRIMMING COMMENT: LUNG SECTION MISSING FROM WET TISSUE AT TIME OF TRIMMING
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG|. L F . TESTIS (TEO|, PROSTATE (PR). SEMINAL VESICLE |SV), URETHRA (UR)
oO f0v0)
N
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 135
ANIMAL NUMBER: C67585
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF OEATH. 02/14/91
STUOY DAY OF DEATH. 57
STUDY WEEK OF DEATH: 9
TERMINAL BODY WEIGHT. 450.7 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 9:13
PROSECTOR: KEVIN BILLINGS
RECORDER: JILL SEVAN
POST-FIX WEIGHER. NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR!1
LIVER LUNG
jLI (LU)
11
LF. TESTIS (TEO)
RT. TESTIS (TEI
ACCESS/SEX ORO (SO)
2.0252 19.3391
1.5089 1 5553 1.5990 3 0681
.4493 X 4.2909 X
.3343 X .3451 X .3526 X .8803 X
1.0000 9.5492
.7441 .7690 .7848 1.5140
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * * PATHOLOGY' OBSERVATIONS * * *
KEYWORDS, SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL CO M E N T oiosl: -ALL TISSUE/ORGANS NORMAL
LIVER a n MICRO: -MINIMAL
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE `PLUMP* APPEARANCE. EXCEPT FOR THIS `ENLARGED* APPEARANCE, THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD |CG), LF . TESTIS (TEO). LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
TUS)>
frajzoo
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX 0 INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: U-OCT-91
PAGE: 136
ANIMAL NUMBER: C675I6
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH. 02/13/91
STUDY DAY OF DEATH: 58
STUDY WEEK OF DEATH: I
TERMINAL BOOY WEIGHT: 413.7 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 1:35
PROSECTOR: JULIE A. LARSEN
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER. JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BRI LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT TESTIS (TCI) ACCESS/SEX ORG (SO)
2.0116 15.1206
1.4646 1 6005 1 5756 3. S940
.5032 X 3.6242 X
.3541 X .3669 X .3609 X .6667 X
1.0000 7.6002
.7037 .7669 7570 1 7266
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
*" P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COFWENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNOEO GIVING THE CELLS A MORE 'PLUMP' APPEARANCE. EXCEPT FOR THIS 'ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR). COAGULATING GLD (CG). L F . TESTIS (TEO), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
jj6T200
Uo)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY OATA
HWI 6329-100 PRINTED: 1S-OCT-B1
PAGE: 137
ANIMAL NUMBER: C675I7
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUOY DAY OF DEATH: SS
STUDY WEEK OF DEATH: I
TERMINAL OOY WEIGHT: 493.0 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 1:59
PROSECTOR: RUTH SCHMITZ
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI 1 LUNG |LU) LF. TESTIS (TEO) RT. TESTIS 1TE1} ACCESS/SEX ORG (SO)
2.2704 10 5473
1.5632 1.6964 1 7142 3.9945
.4605 X 3.9650 X
.3171 X .3441 X .3477 X .1102 X
1.0000 6.6096
.6665 .7472 .75SO 1.7594
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * P A T H O L O G Y ' O B S E R V A T I O N S *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) .................................... .............................................................
GROSS: -ALL TISSUES/ORQANS NORMAL
LIVER (LI) ......................................................................................................................
MICRO: -MINIMAL
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR
THIS ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). L F . TESTIS (TEO). LUNG |LU). PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR |
N P
S
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 18-OCT-91
PAGE: 131
ANIMAL NUMBER. C6TSS9
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/17/91
STUDY DAY OF DEATH: 149
STUDY WEEK OF DEATH. 22
TERMINAL BODY WEIGHT: 571.7 GRAMS
DATE AND TIME OF NECROPSY: 05/17/91 7:31
PROSECTOR: DEBBIE PIRKEL
RECORDER: JOE N. K1ZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST. DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER |LI) LUNG (LU) LF TESTIS (TEO) RT TESTIS (TElj ACCESS/SEX ORG (SO)
2 1157 17.7967
1 5797 1 5047 1 5663 3.5672
.3123 X 3.1129 X
2763 X 2632 X 2740 X .6240 X
1.0000 1 1423
.7227 .6184 .7166 1.6321
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOGY' O B S E R V A T I O N S *
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT |QC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR|. COAGULATING OLD (CO). L F . TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (Ult)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: II-OCT-91
PAGE: 139
ANIMAL NUMBER: C675I9
SEX: MALE
DOSE GROUP. 3
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/16/91
STUDY DAY OF DEATH: 141
STUOY WEEK OF DEATH. 22
TERMINAL BOOY WEIGHT: 630.1 GRAMS
DATE AND TIME OF NECROPSY: 05/16/91 7:47
PROSECTOR: GAIL M. NOVAK
RECORDER: JOE N. KIZ2IEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR 1 LIVER |LI i LUNG (LU) LF TESTIS (TEO) RT. TESTIS (TEI) ACCESS/SEX ORG (SO)
2.1170 21.7957
2 1373 2 0235 2.1199 3.6165
.3467 X 3.4552 X
.3311 X .3201 X .3361 X .5733 X
1.0000 9.0660
.9773 .9252 .9693 1.6538
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y ' O B S E R V A T I O N S
KEYWORDS. SEVERITY, DISTRIBUTION
OROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI .........................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER |LI) ....................................................................................
MICRO: -MODERATE, FOCAL
-FATTY CHANGE
GENERAL INFORMATION |XX) .....................................................................
GROSS:
NECROPSY NOTE: >ANIMAL PRIOR TO EXSANGUINATION
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CGI. LF . TESTIS (TEO). LUNG (LU|. PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
n
o
h*
&
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX 0 INDIVIDUAL ANIMAL PATHOLOOY DATA
HWI 6329-100 PRINTED: H-OCT-91
PAGE: 140
ANIMAL NUMBER: C67590
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL ODY WEIGHT: 391.4 GRAMS
DATE AND TIME OF NECROPSY. 01/24/91 t:5t
PROSECTOR: JULIE A. LARSEN
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X|
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TEI ACCESS/SEX (IRQ (SO)
2.2534 17.2091
1.4(66 1.SS2I 1 5279 2.5767
.5757 X 4.3966 X
.3799 X .3967 X .3904 X .65(3 X
1.0000 7.6369
.6597 .6(91 .67(0 1.1435
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS *** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN JBR|, COAGULATING GLD (CG|. L F . TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (U6)
r> o
N
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-Bi
PAGE: 141
ANIMAL NUMBER: C6TS91
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUOY DAY OF DEATH. 35
STUDY WEEK OF DEATH: 5
TERMINAL OOY WEIGHT: 379.3 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 1:49
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS|
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN IBRI LIVER (LI) LUNG (LU) IF TESTIS (TEO) RT.TESTIS 1TE1) ACCESS/SEX ORG (SO)
1.9910 16.6859
1 4326 1.5712 1 5455 2.1492
.5261 X 4.3939 X
.3777 X .4161 X .4075 X .7512 X
1 0000 1.3413
.7170 .7699 .7735 1.4260
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER (LI) ............................................ ......................................................................
MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR
THIS 'ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
SKIN (SK) ....................................................................................................................
GROSS: -CRUSTED AREA(S)
-MID DORSAL THORACIC REGION:DARK RED CRUSTED AREAS.
15 X 10 MM (CAP 6)
MICRO: -MODERATE. FOCAL
-DERMATITIS
HISTOPATHOLOOICAL COMMENT: >FOCAL, SUBACUTE TO CHRONIC DERMATITIS WITH EPIDERMAL HYPERPLASIA
AND FOCAL EXUDATE FORMATION. FOCAL GRANULOMATOUS INFLAMMATION
IN THE DERMIS AND AROUND HAIR FOLLICLES.
HAZLETON LABORATORIES AMERICA. INC. MAOISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 142
ANIMAL NUMBER: C6TS91
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUOY DAY OF DEATH: 3S
STUDY WEEK OF OEATH. 5
TERMINAL BODY WEIGHT. 379.3 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 1:49
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING GLD (CGI. LF. TESTIS (TE0|, LUNG (LU|, PROSTATE (PR). SEMINAL VESICLE (SV), URETHRA (UR)
(" I 01
r-o o
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-OCT-B1
PAGE: 143
ANIMAL NUMBER: C67592
SEX. MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 341.1 GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 7:47
PROSECTOR: JULIE A. LARSEN
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI 1 LUNG (LU) LF. TE STlS (TEO) RT. TESTIS TE1 ACCESS/SEX ORQ ISO)
2.1769 14.0101
1.2991 1 5136 1.5352 2.6531
.6369 X 4.0999 X
.3103 X .4421 X .4492 X .7762 X
1.0000 6.4351
.5971 .6953 .7052 1.2191
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * P A T H O L O G Y ' O B S E R V A T I O N S *
KEYWORDS. SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR |, COAGULATING GLD (CG). L F . TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE |PR), SEMINAL VESICLE (SV). URETHRA (UR)
u
0022 $.0
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE. 144
ANIMAL NUMBER. C67593
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, FIRST POST-RECOV SAC
DATE OF DEATH: 05/16/91
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 709.S GRAMS
DATE AND TIME OF NECROPSY: 05/16/91 7:43
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. KIZ21EE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS 1
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STA 7U S
BRAIN (BR|1
LIVER LUNG
|L(UL)I]1
LF. TESTIS ITE01
RT. TESTIS (TEI
ACCESS/SEX ORG (SO)
2.0594 20.5211
1.5600 1.9691 1.1414 3.7032
.2903 X 2.1923 X
.2199 X .2634 X .2605 X .5219 X
1.0000 9 9646
.7575 .9076 .1975 1.7912
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y ' O B S E R V A T I O N S
KEYWORDS, SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR I COAGULATING GLD (CG). LF. TESTIS |TE0). LIVER ILI). LUNG |LU). PROSTATE |PR|, SEMINAL VESICLE (SV|. URETHRA (U*|
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-Bl
PAGE: 146
ANIMAL NUMBER: C6T595
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUDY DAY OF DEATH: 35
STUDY WEEK OF DEATH: 5
TERMINAL BOOY WEIGHT: 14.9 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 6:04
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: OAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER )LI) LUNG (LU) LF TESTIS ([TEOI RT TESTIS ITEI ACCESS/SEX Ofla ISO)
2.0247 19 3969
1 55*2 1.9551 1 9029 3.5599
.4990 X 6751 X
3756 X .4471 X .4345 X .9590 X
1.0000 9.5901
.7696 .9162 .9905 1.7592
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O Q KEYWORDS. SEVERITY. DISTRIBUTION
BSER VA T IONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER 1L) ................................... MICRO: -MINIMAL. FOCAL -MINIMAL
INFILTRATES.MONONUCLEAR CELL HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR THIS 'ENLARGED' APPEARANCE, THE CELLS ARE OTHERWISE 'NORMAL' .
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG), LF. TESTIS (TEG). LUNG UU). PROSTATE (PR|, SEMINAL VESICLE (SV|, URETHRA (UR)
OZZOO
uvio
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HUI 6329-100 PRINTED: 1I-0CT-B1
PAGE: 14S
ANIMAL NUMBER: C67594
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULEOJ SECOND INTERIM SACRIFICE
DAtE OF DEATH: 02/13/91
STUDY DAY OF DEATH. 56
STUDY WEEK OF DEATH: I
TERMINAL OOY WEIGHT: 523.6 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 1:23
PROSECTOR: DENNIS HOFFMAN
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU| IF. TESTIS (TEO| RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2.0620 21.2955
1.6331 1.7855 1.7998 3.9196
.3937 X 4.0656 X
.3116 X .3409 X .3434 X .7493 X
1.0000 10.3276
.7920 .1659 1724 1.9009
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIOHT TAKEN
ORGAN NAME
* P A T H O L O G Y ' O B S E R V A T I O N S
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) .............................................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ..................................................................................................................
MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BOROERS ARE MORE
ROUNDED GIVING THE CELLS A MORE *PLUMP` APPEARANCE. EXCEPT FOR
THIS -ENLARGED- APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). L F . TESTIS |TEO), LUNG (LU). PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR 1
HAZLETON LABORATORIES AMERICA. INC. MAOISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED. 1-OCT-91
PAGE: 147
ANIMAL NUMBER. C67S96
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: Sll.S GRAMS
DATE AND TIME OF NECROPSY. 03/26/91 7:41
PROSECTOR: STEVE VAN ADESTINE
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (Lit LUNG (LU) LF. TESTIS (TEO) RT. TESTIS It e i I ACCESS/SEX <)RG (SO)
2.2403 20.2379
1 4079 1.6654 1.6369 4.5671
.4360 X 3.9566 X
.2752 X .3256 X .3200 X .1930 X
1.0000 9.0336
.6294 .7434 .7307 2.0369
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A TH OL OG Y- O B S E R V A T I O N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) GROSS : -ALL TISSUES/ORGANS NORMAL
LIVER (LI I MICRO: -MINIMAL. FOCAL -MINIMAL
PROSTATE (PR) MICRO: -SLIGHT. FOCAL
-INFILTRATES,MONONUCLEAR CELL -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR THIS "ENLARGED" APPEARANCE, THE CELLS ARE OTHERWISE "NORMAL". -INFLAMMATION. CHRONIC ACTIVE
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD |CG). LF. TESTIS (TEO). LUNG (LU|. SEMINAL VESICLE (SV|. URETHRA (UR)
(QOZZO
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE: 141
ANIMAL NUMBER: C6TS97
SEX: MALE
OOSE GROUP: 3
SACRIFICE STATUS. SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH. 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL BOOY WEIGHT: 360.0 GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 6:26
PROSECTOR: DENNIS HOFFMAN
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS .(TEO) RT. TESTIS (TEI ACCESS/SEX ()RG (SO)
2.0027 19.4226
1.4474 1.4949 1.5566 2.6580
.5270 X 5.1113 X
.3609 X .3934 X .4097 X .6969 X
1.0000 9.6963
.7227 .7464 .7774 1 3262
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWOROS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ...........................................................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ....................................................................................................................
MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE `PLUMP* APPEARANCE. EXCEPT FOR
THIS `ENLARGED" APPEARANCE, THE CELLS ARE OTHERWISE `NORMAL'.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG) , L F . TESTIS (TEO). LUNG |LU). PROSTATE (PR). SEMINAL VESICLE |SV), URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 149
ANIMAL NUMBER: C67S9I
SEX: MALE
OOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 534.3 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 1:13
PROSECTOR: DEBBIE PIRKEL
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZ1EE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR| LIVER (LI) LUNG |LU) LF TESTIS (TEO) RT. TESTIS (TElj ACCESS/SEX ORG (SO)
2.0731 22.4725
1.6013 1.6629 1.6661 2.6754
.3660 X 4.2060 X
.3010 X .3112 X .3116 X .5362 X
1.0000 10.6400
.7756 .6021 .6037 1.3670
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) .................................. .................................... ...............................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI I ......................................................................................................................
MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE "PLUMP* APPEARANCE. EXCEPT FOR
THIS "ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BRI. COAGULATING GLD (CG). L F . TESTIS (TEO), LUNG (LU), PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX 0 INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 8329-100 PRINTED ll-OCT-91
PAGE: ISO
ANIMAL NUMBER. C8TS99
SEX. MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH. 01/23/91
STUDY DAY OF DEATH : 35
STUDY WEEK OF DEATH: 5
TERMINAL BODY WEIGHT: 407.5 GRAMS
OATE AND TIME OF NECROPSY: 01/23/91 9:17
!PROSECTOR : DENNIS HOFFMAN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
!PATHOLOGIST: DR . TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO 1BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT TESTIS (TE1) ACCESS/SEX ORG (SO)
1.92M 20 7114
1.5219 1.7114 1.6142 2.3145
.4733 X 5.0143 X
.3752 X .4200 X .4133 X .5152 X
1.0000 10.7416
.7927 .1173 .1732 1.2363
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * * PA T H 0 L 0 G Y O S S E R V A T I 0 N S
KEYWORDS, SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) .................................
...........................................................
GROSS: -ALL TISSUES/ORGANS NORMAL LIVER (LI) ......................................................................................................................
MICRO: -MINIMAL
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATEO PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE `PLUMP" APPEARANCE. EXCEPT FOR
THIS "ENLARGEO" APPEARANCE, THE CELLS ARE OTHERWISE "NORMAL" .
GENERAL INFORMATION (XX) ................. ............................................ .......................
GROSS:
NECROPSY NOTE: >ANIMAL DIED PRIOR TO EXSANQUINATION
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR), COAGULATING GLD |CG|, LF. TESTIS (TE0|, LUNG (LU). PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 18-OCT-91
PAGE: 1S1
ANIMAL NUMBER: C67600
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL BOOY WEIGHT: 595.1 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 9:26
PROSECTOR: DEBBIE PIRKEL
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2.2575 24.7003
1.7639 1.7IOL 1.7600 3.5697
.3793 X 4.1506 X
.2964 X .2991 X .2957 X .5998 X
1.0000 10.9414
.7814 .7185 .7796 1.5813
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
GENERAL COMMENT IGC) GROSS : -ALL T ISSUES/ORQANS NORMAL
LIVER (LI) MICRO: -MINIMAL, FOCAL -MINIMAL
-INFLAMMATION,GRANULOMATOUS -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCVTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP' APPEARANCE. EXCEPT FOR THIS 'ENLARGED' APPEARANCE, THE CELLS ARE OTHERWISE 'NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). LF . TESTIS (TEO), LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (S V ), URETHRA (UR)
00221C
cn
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-Oi
PAGE: 1S2
ANIMAL NUMBER: C67601
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 410.6 GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 9:41
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BRI LIVER (Lit LUNG (LU) LF. TESTIS (TE01 RT TESTIS (TE1J ACCESS/SEX ORG (SO)
2.1563 21 9925
1.7051 1.6701 1.7349 3.3149
.4497 X 4.5552 X
.3549 X .3475 X .3610 X .6997 X
1.0000 10.1529
.7909 .7745 .9046 1.5373
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * * P A T H O L O G Y - O B S E R V A T I O N S *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
AcQiCOAGULATING OLD GROSS:
NECROPSY NOTE: >TRIMMING COMMENT: MISSING FROM WET TISSUE AT TIME OF TRIMMING
MICRO: -TISSUE MISSING
GENERAL COMMENT IOC)
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) . . . .
MICRO: -MINIMAL
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE `PLUMP' APPEARANCE. EXCEPT FOR
THIS -ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL'.
PROSTATE (PRJ . . .
GROSS:
NECROPSY NOTE: >TRIMMING COMMENT: MISSING FROM WET TISSUE AT TIME OF TRIMMING
MICRO -TISSUE MISSING
SEMINAL VESICLE (SV)
NECROPSY NOTE: TRIMMING COMMENT: MISSING FROM WET TISSUE AT TIME OF TRIMMING
MICRO: -TISSUE MISSING
URETHRA (UR |
GROSS :
NECROPSY NOTE! TRIMMING COMMENT: MISSING FROM WET TISSUE AT TIME OF TRIMMING
O'
N N
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 19-OCT-91
PAGE: 1S3
ANIMAL NUMBER: C6760I
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 6
TERMINAL OOY WEIGHT: 410.6 GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 1:41
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
P A T H O L O G Y O B S E R V A T I O N S (CONTINUED) * * *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
URETHRA (UR) ..................................................... MICRO: -TISSUE MISSING
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). LF. TESTIS (TEO), LUNG (LU)
N
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A .
APPENDIX O INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-Ol
PAGE: ISA
ANIMAL NUMBER: C67602
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDY DAY OF DEATH: 57
STUDY WEEK OF DEATH: 9
TERMINAL BOOY WEIGHT: 504.0 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 9:49
PROSECTOR: KEVIN BILLINGS
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR)
LIVER jLI)
LUNG (LU)
LF. TESTIS ITEOj
RT TESTIS ACCESS/SEX
ORGTE1 (SO)
2.0979 20.2097
1.6142 1 9214 1 9926 3.0233
.4162 X 4.0099 X
.3203 X .3912 X .3735 X .5999 X
1.0000 9.6339
.7695 .9159 .9974 1.4412
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
O B S E R V A T I O N S GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL CO m E N T (QC) .......................................................................... .....................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER |LI) ................................................................................................................
MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE `PLUMP' APPEARANCE. EXCEPT FOR
THIS `ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL" .
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD ICO). LF . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA |UR)
TZZOO
oo
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED. ll-OCT-Ol
PAGE: 1SS
ANIMAL NUMBER: C67603
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 609.4 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 9:36
PROSECTOR: KEVIN BILLINGS
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT 1GRAMS 1
ORGAN WEIGHT RELATIVE TO BOOT WEIGHT (X|
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS TEO RT. TESTIS (t e i ) ACCESS/SEX ()RG (SO)
2.1709 22.3011
1.7242 1.6944 1.6667 3.2306
.3S62 X 3.6607 X
.2929 X .2764 X .2769 X .5301 X
1.0000 10.2760
.7942 .7759 .7770 1.4991
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y ' O B S E R V A T I O N S * *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCJ
.................................... ................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ......................................................................................................................
MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE "PLUMP' APPEARANCE. EXCEPT FOR
THIS `ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL' .
PROSTATE (PR| ....................................................................................................................
MICRO: -SLIGHT, MULTI-FOCAL
-INFLAMMATION. CHRONIC ACTIVE
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). L F . TESTIS (TEO), LUNG (LU). SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 1S6
ANIMAL NUMBER: C67804
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 556.1 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 9:10
PROSECTOR: RUTH SCHMITZ
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS TEO) RT. TESTIS (TEI ACCESS/SEX ()RG SO)
2.1210 19.9391
1.7130 1.9040 1.6120 3.4395
.3114 X 3.5155 X
.3010 X .3424 X .3314 X .6115 X
1.0000 9.4001
.1076 .6977 .6673 1.6216
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC I GROSS : -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -SLIGHT. FOCAL -MINIMAL
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR
THIS "ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). LF . TESTIS (TEO). LUNG |LU|. PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
G922
cOn
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-OCT-B1
PAGE: 1ST
ANIMAL NUMBER: C6760S
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL ODV WEIGHT: 573.2 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 9:39
PROSECTOR: DEBBIE PIRKEL
RECORDER. JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR1 LIVER 1LI I LUNG (LU) LF. TESTIS ITE01 RT. TESTIS (TEI) ACCESS/SEX ()RG (SO)
2.2442 22.2101
1.6579 1.7716 1.7167 3.2634
.3915 X 3.1741 X
.2192 X .3091 X .3117 X .5693 X
1.0000 9.1969
.7316 .7194 .7962 1.4542
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L O G Y - O B S E R V A T I O N S *
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI .................................... .............................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER |LI | ......................................................................................................................
MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE `PLUMP* APPEARANCE. EXCEPT FOR
THIS `ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL" .
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD ICG), L F . TESTIS |TEO|, LUNG |LU|, PROSTATE (PR), SEMINAL VESICLE (SV|. URETHRA (UR)
TZZOO
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN US .A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-01
PAGE: 1SI
ANIMAL NUMBER: C67606
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDY DAY OF DEATH: 57
STUDY WEEK OF DEATH: 9
TERMINAL BODY WEIGHT: 475.9 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 1:34
PROSECTOR: KEVIN BILLINGS
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO ) RT. TESTIS (TE1 ACCESS/SEX ORG (SO)
2.0932 16.7844
1.2771 1.7686 1.8576 2.9217
.4398 X 3.5269 X
.2685 X .3716 X .3903 X .6139 X
1.0000 8.0185
.6105 .8449 .8874 1.3958
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATI 0 NS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC GROS!S: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE `PLUMP* APPEARANCE. EXCEPT FOR THIS 'ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD |CG|, L F . TESTIS (TEO), LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-Ol
PAGE: 1S9
ANIMAL NUMBER: C67607
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 527.1 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 l:0S
PROSECTOR: STEVE VAN ADESTINE
RECORDER: TILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: TOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN IBR) LIVER (LI LUNG (LU) LF. TESTIS ITEO) RT. TESTIS (TElj ACCESS/SEX ORG (SO)
2.0524 17.1774
.9333 1.1299 1.1218 2.5374
.3194 X 3.3917 X
.1771 X .3472 X .3456 X .4114 X
1.0000 1.7105
.4547 .1916 .1175 1.2383
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
*** PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S ** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
GENERAL COMMENT (QCI .......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR). COAGULATING OLD (CG). L F . TESTIS (TE0|, LIVER |LI|, LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV), URETHRA (UR)
ctnJ
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 160
ANIMAL NUMBER: C67606
SEX: HALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/25/91
STUOY DAY OF DEATH: 96
STUOY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 500.4 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 1:36
PROSECTOR: JACK SERFORT
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER 1LI) LUNG (LU) LF. TESTIS ITEO) RT. TESTIS TEI ACCESS/SEX ORO (SO)
2 0934 17 2484
1 5348 1.8529 1.7698 3 2045
4183 X 3.4469 X
.3067 X .3703 X .3537 X .6404 X
1.0000 8.2394
.7332 .8851 .8454 1.5308
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (QCI GROSS : -ALL TISSUES/ORGANS NORMAL
LIVER | U | MICRO: -MINIMAL. FOCAL -MINIMAL
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR THIS 'ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL'.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG), LF . TESTIS (TEO), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
o
K)
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-Ol
PAGE: 161
ANIMAL NUMBER: C67609
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, FIRST POST-RECOV SAC
DATE OF DEATH: OS/17/91
STUDY DAY OF DEATH: 149
STUDY WEEK OF DEATH: 22
TERMINAL BOOY WEIGHT: 730.9 GRAMS
DATE AND TIME OF NECROPSY: 05/17/91 1:53
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DENNIS HOFFMAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR| LIVER (LI) LUNG |LU| LF. TESTIS (TEO) RT. TESTIS |TE1) ACCESS/SEX ORG (SO)
2 2519 11.0752
1.5201 1.7566 1.1661 3.2434
.3091 X 2.4730 X
.2011 X .2403 X .2556 X .4431 X
1.0000 001
.6732 .7776 .1270 1 4351
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y ' O B S E R V A T I O N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI .......... GROSS: -ANIMAL OBESE
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|. COAGULATING GLD |CQ|, L F . TESTIS (TEO), LIVER (LI). LUNO (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR|
n
iinn N
N
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6320-100 PRINTED: ll-OCT-01
PAGE: 162
ANIMAL NUMBER: C67610
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/25/01
STUDY DAY OF DEATH: 06
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 541.1 GRAMS
DATE AND TIME OF NECROPSY 03/25/01 0:56
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: STEVE VAN AOESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR)
LIVER (LI)
LUNG (LU)
LF. TESTIS (TEOJ
RT. TESTIS ACCESS/SEX
OROTE1 (SO)
2.4004 16.4563
1.7266 1.7350 1.7363 4.0026
.4306 X 3.3677 X
.3151 X .3165 X .3172 X .7303 X
1.0000 7.6610
.7167 .7201 .7215 1.6612
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER ILI I ................................... MICRO: -MINIMAL
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR THIS `ENLARGED' APPEARANCE, THE CELLS ARE OTHERWISE `NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CO). L F . TESTIS (TEO|, LUNG (LU). PROSTATE fPR), SEMINAL VESICLE (SV). URETHRA (UR)
fZZZGO
io>n
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 163
ANIMAL NUMBER: C 6 7 6 U
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/2S/91
STUDY DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL ODY WEIGHT: 529.2 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 9:21
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER |LI) LUNG (LU) LF TESTIS (TEO) RT. TESTIS |TE1) ACCESS/SEX ORQ (SO)
2.1143 11.I I M
1.4205 1.6407 1.7111 3.9513
.4121 X 3.5693 X
.2614 X .3100 X .3235 X .7410 X
1.0000 1.6475
.8503 .7511 .7137 1.1122
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI ....................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) .................................... MICRO: -MINIMAL. FOCAL -MINIMAL
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR THIS "ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL"
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). LF . TESTIS (TEO), LUNG (LU). PROSTATE (PR|. SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 164
ANIMAL NUMBER: CS7612
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDV DAY OF DEATH: 55
STUDY WEEK OF DEATH: t
TERMINAL BODY WEIGHT: 469.9 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 9:02
PROSECTOR: NANCY DIEDRICH
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN' STATUS
BRAIN (BR) LIVER ILI 1 LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORQ (SO)
2 0627 19 6334
1 5619 1 6696 1 6955 2.9469
.4390 X 4.1792 X
.3339 X .3551 X .3609 X .6271 X
1.0000 9.5193
.7606 .9099 .9220 1.4296
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y ' O B S E R V A T I O N S
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN fBR) COAGULATING OLD (CG). LF . TESTIS (TEO). LIVER (LI 1. LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
ZZ3
iono
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-OCT-91
PAGE: 16S
ANIMAL NUMBER: C67613
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 583.2 GRAMS
OATE AND TIME OF NECROPSY: 03/22/91 7:24
PROSECTOR: KEVIN BILLINGS
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
A8S0LUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI 1t LUNG (LU) LF TESTIS ITEOJ RT. TESTIS ITE1 ) ACCESS/SEX ORG |S0)
2.2002 21.3304
1.74(2 1.64(2 1.6651 3.1016
.3773 X 3.6575 X
.2998 X .2(26 X .2(55 X .5318 X
1.0000 9.6948
.7946 .7491 .7568 1.4097
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * * PATHOLOGY- O B S E R V A T I O N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CO). LF . TESTIS (TEO|, LIVER (LI). LUNG (LU), PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR)
fazZZQO
itno
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 166
ANIMAL NUMBER: C67614
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDY DAY OF DEATH: 57
STUDY WEEK OF DEATH: 9
TERMINAL AoOV WEIGHT: 419.4 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 1:15
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN 1BR| LIVER (LI I LUNG (LU) LF. TESTIS ITEO) RT. TESTIS It e i I ACCESS/SEX ()RG (SO)
2.0662 19.1019
1.4512 1.6205 1 6179 3.5666
.4222 X 4.0476 X
.2990 X .3311 X .3306 X .7299 X
1.0000 9.5971
.7057 .7943 .7930 1.7262
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
*** PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATI 0 N S * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEY)S| (KOI
GROSS: -LARGE PELVIS(ES)
-BILATERAL
MICRO: -PRESENT
-DILATATION.PELVIC
LIVER |LI) ......................................................................................................................
MICRO: -MINIMAL
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR
THIS "ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). L F . TESTIS ITEO). LUNG (LU). PROSTATE fPR). SEMINAL VESICLE (SV). URETHRA (UR|
n
<OJ\
N
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 167
ANIMAL NUMBER: C67615
SEX: MALE
DOSE GROUP: 3
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH. 03/2S/91
STUDY DAY OF DEATH: 96
STUDY WEEK OF DEATH; 14
TERMINAL 600V WEIGHT: 529.4 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 1:11
PROSECTOR: JACK SERFORT
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER |LIi LUNG (LU) LF. TESTIS TEO RT. TESTIS Itei ACCESS/SEX ()RG SO)
2.1700 16.1536
1.6116 1.1900 1 1593 3.2906
.4099 X 3.1935 X
.3044 X .3570 X .3512 X .6216 X
1.0000 7.7666
.7427 .1710 .1561 1.5164
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
GENERAL COMMENT (GC) .................................... ...................................... .................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ....................................................................................................................
MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCVTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR
THIS "ENLARGEO" APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR), COAGULATING GLD (CG). L F . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
o
ro w
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 19-OCT-91
PAGE: 169
ANIMAL NUMBER: CB7B16
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/25/91
STUDY DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 596.9 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 9:41
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE M. K12ZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR|
LIVER (Lit LUNG (LU)
'
LF. TESTIS (TEOj
RT. TESTIS )tei I
ACCESS/SEX (M G (SO)
2.1793 26.1955
1.6794 2.0033 1.9311 3.7409
.3712 X 4.4641 X
.2960 X .3414 X .3291 X .6375 X
1.0000 12.0257
.7705 .9197 .9965 1.7173
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL, FOCAL -MINIMAL
-INF LAMMATION,GRANULOMATOUS -HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR THIS "ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG), LF. TESTIS (TEO|, LUNG (LU). PROSTATE (PR|, SEMINAL VESICLE (SV), URETHRA |UR|
tizzz-a
<INn
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 169
ANIMAL NUMBER: C6T61T
SEX. MALE
DOSE GROUP. 4
SACRIFICE STATUS. SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH: 56
STUDY WEEK OF DEATH: I
TERMINAL ODY WEIGHT: 426.1 GRAMS
DATE AND TIME OF NECROPSY: 02^13/91 7:24
PROSECTOR: RUTH SCHMITZ
RECORDER: KEVIN BILLINGS
POST-FIX WEIOHER: NOT AVAILAB
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN fBR)
LIVER (LI | LUNG (LU)
'
LF. TESTIS (TEO)
RT. TESTIS It e i )
ACCESS/SEX ()RG (SO)
1.9141 22.6410
1.4213 1.5916 2.4211 3.6044
.4827 X 5.2101 X
.3315 X .3712 X .5641 X .6406 X
1.0000 11.4112
.7163 .6022 1.2206 1.6166
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOQ KEYWORDS. SEVERITY. DISTRIBUTION
B SE RVA T IO NS GROSS FREE- TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) ......................... GROSS: -ALL TISSUES/ORQANS NORMAL
LIVER (LI) .................................... MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTR1LOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE `PLUMP* APPEARANCE. EXCEPT FOR THIS `ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR), COAGULATING OLD (CQ|, L F . TESTIS (TEO), LUNG (LU). PROSTATE (PR|, SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-Bl
PAGE: 170
ANIMAL NUMBER: C6761I
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL ODY WEIGHT: 596.6 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 1:54
PROSECTOR: RUTH SCHMITZ
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS TEO RT. TESTIS (TEI ACCESS/SEX ()RG (SO)
2 1651 22 6115
1 6356 1 7611 1 7267 3 9577
.3629 X 3.1241 X
.2742 X .2953 X .2194 X .6634 X
1.0000 10.5302
.7554 .1137 .7975 1.1260
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * * PATHOLOGY' OBSERVATIONS
KEYWORDS. SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) .................................................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER |LI) ....................................................................................................................
MICRO: -SLIGHT. FOCAL
-INFLAMMATION,GRANULOMATOUS
-MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTR1LOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE "PLUMP* APPEARANCE. EXCEPT FOR
THIS 'ENLARGEO* APPEARANCE, THE CELLS ARE OTHERWISE `NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING GLO (CG). L F . TESTIS (TEO), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV), URETHRA (UR)
OV
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE: 171
ANIMAL NUMBER: C67619
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 409.2 GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 1:44
PROSECTOR: JULIE A. LARSEN
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER jLIf LUNG (LU) LF. TESTIS TEO) RT. TESTIS It e i ) ACCESS/SEX ()RQ |SO)
2.0982 26.3509
1.5621 1.5736 1.5917 2.4021
.5123 X 6.4396 X
.3117 X .3646 X .3907 X .5170 X
1.0000 12.5701
.7452 .7507 .7627 1.1459
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOQ KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) GROSS : -ALL TISSUES/ORGANS NORMAL
LIVER ILI I MICRO: -MINIMAL, MULTI-FOCAL -MINIMAL
-INFILTRATES,MONONUCLEAR CELL -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE "PLUMP* APPEARANCE. EXCEPT FOR THIS "ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR1. COAGULATING GLD (CG). LF . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
C02234)
toni
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE: 172
ANIMAL NUMBER : C67620
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 6
TERMINAL OOY WEIGHT: 469.1 GRAMS
DATE AND TIME OF NECROPSY 01^25/91 9:01
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILAB
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER |LI| LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2.0154 25.3547
1.4147 1.5066 1.4394 3.1123
.4290 X 5.3969 X
.3160 X .3207 X .3064 X .6774 X
1.0000 12.5105
.7367 .7475 .7142 1.5790
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L O G KEYWORDS, SEVERITY. DISTRIBUTION
BSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ................................... MICRO: -SLIGHT. FOCAL -SLIGHT
-INF LAMMATION.GRANULOMATOUS -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP" APPEARANCE. EXCEPT FOR THIS `ENLARGED' APPEARANCE, THE CELLS ARE OTHERWISE 'NORMAL' .
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD ICG). LF. TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV), URETHRA (UR)
OS Os
N
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED K-OCT-91
PAGE: 173
ANIMAL NUMBER: C6T621
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL ODY WEIGHT: 607.0 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 7:39
PROSECTOR: DEBBIE PIRKEL
RECOROER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS ITEl) ACCESS/SEX ()RG (SO)
2.2076 2S.OS27
1.7479 1.6519 1.6305 2.4959
.3637 X 4.1273 X
.2160 X .2733 X .2616 X .4112 X
1.0000 11.3414
.7911 .7514 .7316 1.1306
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** PATHOLOG KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL, FOCAL -MINIMAL
-INFILTRATES,MONONUCLEAR CELL -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE `PLUMP* APPEARANCE. EXCEPT FOR THIS `ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL-.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG), L F . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA |UR|
'fCZZOO
CTl
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-Bl
PAGE: 174
ANIMAL NUMBER. C6TB22
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/17/91
STUDY DAY OF DEATH: 149
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 563.6 GRAMS
DATE AND TIME OF NECROPSY: 05/17/91 7:25
PROSECTOR: RUTH SCHMITZ
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS 1
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN IBR1 LIVER (LI) LUNG ILU) IF TESTIS (TEO) RT TESTIS 1TE1 ACCESS/SEX ORG 1SO)
2.1055 21 3009
1.5222 1.8721 2 0008 3.S7S9
.3736 X 3.7794 X
.2701 X .3322 X .3550 X .6877 X
1.0000 10.1168
.7230 .8891 .9503 1.8408
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * * PATHOLOGY- OSSERVATI 0 N S *
KEYWORDS. SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC] . . 0ROSS: -ALL TISSUE/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|, COAGULATING1 OLD (CG), LF. TESTIS (TEO). LIVERI (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SVI. URETHRA (UR|
gCZZGO
Ol
CO
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED' II-0CT-B1
PAGE: 175
ANIMAL NUMBER: C67623
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/25/91
STUDY DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL OOY WEIGHT: 470.7 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 1:51
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1 1 ACCESS/SEX ORG (SO)
2.1070 17.9421
1.5122 1.6761 1.6621 3.7735
.4476 X 3.6111 X
.3361 X .3561 X .3533 X .1017 X
1.0000 1.5155
.7509 .7955 .7192 1.7909
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * * PATHOLOGY' O B S E R V A T I O N S *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) .................................... ...........................................................
...
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) .............................................. .......................................................................
MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRIL06ULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE 'PLUMP' APPEARANCE. EXCEPT FOR
THIS 'ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL' .
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CO), L F . TESTIS (TEO), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
Jpzzz00
a\ \o
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 176
ANIMAL NUMBER: C67624
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS. SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL ODY WEIGHT: 536.7 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 7:55
PROSECTOR: STEVE VAN ADESTINE
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF TESTIS (TEO]1 RT TESTIS Itei I ACCESS/SEX ()RG 1[SO)
2 1104 26.4596
1 4114 1.7071 17554 3.3664
.3932 X 4.9301 X
.2780 X .3162 X .3271 X .6310 X
1.0000 12.5377
.7020 .6092 .8316 1.6046
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATI 0 NS *** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ................................... MICRO: -MINIMAL. FOCAL -SLIGHT
-INF LAMMATION.GRANULOMA TOUS -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE `PLUMP* APPEARANCE. EXCEPT FOR THIS `ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD ICO). LF . TESTIS (TEO), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR|
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE: 177
ANIMAL NUMBER: C87825
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/2S/91
STUDY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 371.2 GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 9:22
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BRI LIVER (Lit LUNG |LU) LF. TESTIS TEO RT. TESTIS (TEI ACCESS/SEX >RG SO)
2 1277 20 1581
1 5811 1 8535 1 6745 2 8636
.5732 X 5.4305 X
.4207 X .4454 X .4511 X .7178 X
1.0000 9.4741
.7340 .7771 .7870 1 2519
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * PATHOLOGY' OSSERVATI 0 N S *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) .................................. .......................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) .....................................................................................................
MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNOED GIVING THE CELLS A MORE 'PLUMP" APPEARANCE. EXCEPT FOR
THIS 'ENLARGED' APPEARANCE, THE CELLS ARE OTHERWISE "NORMAL'.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). L F . TESTIS (TEO). LUNG (LU|, PROSTATE (PR). SEMINAL VESICLE (SV), URETHRA IUR I
p.EZZO!>
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-01
PAGE: 171
ANIMAL NUMBER: C67626
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/16/91
STUDY DAY OF DEATH: 141
STUOY WEEK OF DEATH: 22
TERMINAL BOOT WEIGHT: 560.2 GRAMS
DATE AND TIME OF NECROPSY: 05/16/91 7:51
PROSECTOR: DEBBIE PIRKEL
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: OR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS 1
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI| LUNG (LU) LF. TESTIS (TEO) RT. TESTIS |TE1) ACCESS/SEX ORG (SO)
2.0641 14.6121
1.6345 1.4775 1 4955 4.2949
.3645 X 3.3224 X
.2914 X .3351 X .3344 X .7667 X
1.0000 9.0171
.7919 .9096 .9143 2.0404
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* p a t h o l o g y "" O B S E R V A T I O N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (QC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING OLD (CG). LF. TESTIS (TEO), LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (U*)
r>
N 0 to
"98*
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-Ol
PAGE: 179
ANIMAL NUMBER. C67627
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUDY DAY OF DEATH: 3S
STUDY WEEK OF DEATH: 5
TERMINAL BODY WEIGHT: 396.2 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 1:37
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
OROAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TEI) ACCESS/SEX ()RG (SO)
2.0441 20.7721
1.5105 1.5123 1.5975 2.5701
.5159 X 5.2430 X
.3112 X .3117 X .4032 X .6417 X
1.0000 10.1623
.7390 .7391 .7115 1.2573
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
*** P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI ............................................................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER |LI) ......................................................................................................................
MICRO: -SLIGHT
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR
THIS 'ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL' .
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR). COAGULATING GLD |CG), L F . TESTIS (TEO). LUNG (LU). PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR)
00223g
u>
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-81
PAGE. 110
ANIMAL NUMBER. C67829
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/16/91
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 668.5 GRAMS
DATE AND TIME OF NECROPSY: 05/16/01 7:01
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. K1ZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT 1GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER }LIj LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1| ACCESS/SEX ORG (SO)
2.2129 21.4594
1.7619 1.1651 1 1660 4.4556
.3320 X 3.2197 X
.2644 X .2791 X .2900 X .6695 X
1.0000 9.6974
.7982 .9429 .9432 2.0135
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * P A T H O L O G Y ' O B S E R V A T I O N S **
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI .................................. .........................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER |LI) ..........................................................................
MICRO: -SLIGHT. MULTI-FOCAL
-NECROSIS.COAGULATIVE
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING GLD (CG). L F . TESTIS (TEO). LUNG (LU), PROSTATE (PR|. SEMINAL VESICLE (SV), URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6328-100 PRINTED: 18-OCT-B1
PAGE: 111
ANIMAL NUMBER: C67629
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDY DAY OF DEATH: 57
STUDY WEEK OF DEATH: 9
TERMINAL BODY WEIGHT: 505.2 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 7:16
PROSECTOR: RUTH SCHMITZ
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (8R) LIVER (LI| LUNG (LU1 LF . TESTIS (TEO) RT, TESTIS 1TEI ) ACCESS/SEX C>RO (SO)
2.1037 27.170S
1.5018 1.(013 1.1955 2.1563
.4164 X 5.37(2 X
.2973 X .3566 X .3752 X .5654 X
1.0000 12.9156
.7139 (563 .9010 1.357(
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER ILI ) .................................... MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCVTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE "PLUMP* APPEARANCE. EXCEPT FOR THIS "ENLARGEO* APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BRI. COAGULATING OLD (CG). L F . TESTIS (TEO). LUNG (LUI. PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE: 112
ANIMAL NUMBER: C67630
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 8
TERMINAL BODY WEIGHT: 457.0 GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 1:42
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI( LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2.0441 27.0511
1.5123 1.6356 1.6673 2.9991
.4474 X 5.9193 X
.3309 X .3579 X .3641 X .6563 X
1.0000 13 2292
.7396 .7999 .1154 1.4667
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOGY' OBSERV AT IO NS * * *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) .........................................................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) .........................................................................................................
MICRO: -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
-SLIGHT
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR
THIS "ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR), COAGULATING GLD (CG), L F . TESTIS (TEO). LUNG (LU), PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR)
O
O
W
vj a*
eo
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 113
ANIMAL NUMBER: C67631
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUOY DAY OF DEATH: 35
STUOY WEEK OF DEATH: 5
TERMINAL BOOY WEIGHT: 361.1 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 9:39
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (1TEO) RT. TESTIS |TE1 ACCESS/SEX OfIG (SO)
2.1312 22 4129
1.4431 1.4196 1.40S5 2.9963
.5592 X 5.6611 X
.3769 X .3726 X .3666 X .7667 X
1.0000 10.5166
.6775 .6662 .6595 1.4069
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ................................... MICRO: -MINIMAL. MULTI-FOCAL -MINIMAL
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR THIS 'ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CQ). L F . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR|
oO
N
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE: 1(4
ANIMAL NUMBER: C87632
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUDY DAY OF DEATH: 35
STUDY WEEK OF DEATH: 5
TERMINAL BODY WEIGHT: 3(6.5 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 (:53
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR) LIVER (LI) LUNG (LU) LF. TESTIS TEO RT. TESTIS (TEI ACCESS/SEX ()RG (SO)
1.9220 19.2926
1 3554 1.5971 1.51(3 2.3953
.4973 X 4.7329 X
.3507 X .4132 X .3928 X .6197 X
1.0000 9.5175
.7052 .6310 .7900 1.2483
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI GROSS : -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -SLIGHT
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE `PLUMP* APPEARANCE. EXCEPT FOR THIS `ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR). COAGULATING GLD (CG). LF TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|, URETHRA (UR)
o
o
to CD
&
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6328-100 PRINTED: ll-OCT-91
PAGE. 1RS
ANIMAL NUMBER: C67633
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUOY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 6
TERMINAL OOY WEIGHT: 453.7 GRAMS
DATE AND TIME OF NECROPSY 01^25/91 1:30
PROSECTOR: NANCY DIEDRICH
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILAB
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS 1
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (1)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TCI) ACCESS/SEX ORG (SO)
2 1741 25.60(1
1.7594 1.7336 1.7207 3.2150
.4792 X 5.6443 X
.3I7( X .3121 X .3793 X .7240 X
1.0000 11.77(7
.(093 .7974 .7915 1.5110
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
0BSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEVfS) (KD LIVER (LI)
SPLEEN (SP)
GROSS: -LARGE PELVISIES) MICRO: -PRESENT
-RIGHT (BOTH KIDNEYS COLLECTED) -DILATATION.PELVIC
MICRO: -MINIMAL. FOCAL -MINIMAL
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR THIS "ENLARGED" APPEARANCE, THE CELLS ARE OTHERWISE "NORMAL".
GROSS: -RAISED FOCUS!I)/AREA(S)
-ALONG MARGIN: SINGLE RED AND TAN FIRM AREA 4 X 3 X 2 MM:
COLLECTED
MICRO: -UNREMARKABLE
HISTOPATHOLOGICAL COMMENT: >N0 MICROSCOPIC CORRELATE TO GROSS OBSERVATION.
jjfcZZ 00
to
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-B1
PAGE: 1S6
ANIMAL NUMBER: C67633
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH. 37
STUDY WEEK OF DEATH. 8
TERMINAL ODY WEIGHT: 453.7 GRAMS
DATE AND TIME OF NECROPSY: 01/2S/91 8:30
PROSECTOR: NANCY DIEDRICH
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR |, COAGULATING GLD |CQ|, L F . TESTIS (TEO). LUNG (LU|. PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MAOISON, WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-Ol
PAGE: 117
ANIMAL NUMBER. C67634
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDY DAY OF DEATH: 5S
STUDY WEEK OF DEATH: I
TERMINAL OOY WEIGHT: 475.1 GRAMS
DATE AND TIME-- OF NEC3ROCPSY: 02/12/91 9:24
PROSECTOR: RUTH SCHMITZ
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TEl| ACCESS/SEX ORG (SO)
2.1173 24.6474
1 5054 1.7292 1.1230 3.0144
.4604 X 5.1171 X
.3169 X .3640 X .3137 X .6492 X
1.0000 11.2614
.6112 .790 .1334 1.4101
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT 1GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL
LUNG (LU)
GROSS: MICRO: -TISSUE MISSING
NECROPSY NOTE:
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNOED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR THIS "ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL" . >TRIMMING COMMENT: LUNG SECTION MISSING FROM WET TISSUE AT TIME OF TRItMING
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|. COAGULATING OLD (CGI, LF. TESTIS (TEO), PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
P.PZZOO
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 111
ANIMAL NUMBER: C6763S
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL BOOY WEIGHT: 544.9 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 9:40
PROSECTOR: STEVE VAN ADESTINE
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR) LIVER |LIi LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2.0595 20.2611
1.5667 1.1101 1.9577 3.0409
.3710 X 3.7197 X
.2175 X .3450 X .3593 X .5511 X
1.0000 9.1416
.7607 .9129 .9506 1.4765
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * PATHOLOGY. O B S E R V A T I O N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COM4ENT IOC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ................................... MICRO: -MINIMAL. FOCAL -MINIMAL
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE `PLUMP* APPEARANCE. EXCEPT FOR THIS 'ENLARGEO' APPEARANCE, THE CELLS ARE OTHERWISE `NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). LF TESTIS (TEO). LUNG (LU|. PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 119
ANIMAL NUMBER: C67636
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 6
TERMINAL 800Y WEIGHT: 315.3 GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 7:45
PROSECTOR: DENNIS HOFFMAN
RECORDER: JACK SERFORT
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER |LI) LUNG (LU) IF TESTIS ITEDl RT. TESTIS TE1 ACCESS/SEX ORO (SO)
2.0247 21.9217
1.5117 1.5013 1.4497 2.4796
.5255 X 5.6195 X
.3942 X .3696 X .3783 X .6436 X
1.0000 10.6271
.7501 .7415 .7160 1.2247
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
0 B SERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER ILI I ................................... MICRO: -MINIMAL
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE `PLUMP* APPEARANCE. EXCEPT FOR THIS `ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|, COAGULATING OLD |CG). LF . TESTIS (TE0|, LUNG |LU|. PROSTATE |PR|. SEMINAL VESICLE (SV). URETHRA (UR)
ouo>
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329*100 PRINTED: ll-OCT-91
PAGE: 190
ANIMAL NUMBER: C67637
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/16/91
STUDY DAY OF DEATH: 141
STUOY WEEK OF DEATH: 22
TERMINAL OOY WEIGHT: 529.9 GRAMS
DATE AND TIME OF NECROPSY: 05/16/91 ( 4 3
PROSECTOR: DEBBIE PIRKEL
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BRI
LIVER LUNG
(LI * (LU)
LF TESTIS (TEO)
RT. TESTIS ACCESS/SEX
ORGTE1 (SO)
2.1437 22 6290
1 6194 1.5730 1.6060 3 3451
.4045 X 4.2704 X
.3111 X .2961 X .3031 X .6313 X
1.0000 10.5560
.71(1 .733( .7492 1.5604
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COPWENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|, COAGULATING GLD (CG). LF . TESTIS (TEO). LIVER (LI I. LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (Uft)
O
O N
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 191
ANIMAL NUMBER: C6783I
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH; 56
STUDY WEEK OF DEATH: I
TERMINAL BODY WEIGHT: 4 1 * 9 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 9:00
PROSECTOR: JULIE A. LARSEN
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
orfOAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI 1 LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TEI 1 ACCESS/SEX ()RQ (SO)
2.1911 28.5405
1.6118 1.4847 1.4910 3.2016
.4412 X 5.4216 X
.3298 X .2998 X .3050 X .8563 X
1.0000 12.1129
.7355 .6815 .6I0S 1.4844
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y ' O B S E R V A T I O N S *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) ...........................................................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ......................................................................................................................
MICRO: -MINIMAL, MULTI-FOCAL
-INFILTRATES.MONONUCLEAR CELL
-SLIGHT
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTR1L0BULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNOED GIVING THE CELLS A MORE 'PLUMP' APPEARANCE. EXCEPT FOR
THIS `ENLARGED' APPEARANCE, THE CELLS ARE OTHERWISE 'NORMAL' .
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). L F . TESTIS (TEO), LUNG (LU ). PROSTATE (PR). SEMINAL VESICLE (SV), URETHRA (UR)
00225(1!
co
in
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE: 192
ANIMAL NUMBER: C67639
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH: 59
STUDY WEEK OF DEATH: I
TERMINAL BODY WEIGHT: 479.0 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 1:10
PROSECTOR: DENNIS HOFFMAN
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
M O A N WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
0RGAN S TA TU S
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS tei ACCESS/SEX ORQ (SO)
2.0544 26.1211
1.4064 1.9760 2.0156 3.2112
.4269 X S .6009 X
.2936 X .4125 X .4201 X .6704 X
1.0000 13.0516
.6646 .9616 .9611 1.5631
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIOHT TAKEN
ORGAN NAME
* * * P A T H O L O G Y ' O B S E R V A T I O N S *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL CO<ENT IOC) .....................................................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ......................................................................................................................
MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATEO PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE "PLUMP* APPEARANCE EXCEPT FOR
THIS "ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). LF . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
002
ooo
N
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 193
ANIMAL NUMBER: C67640
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUOV WEEK OF DEATH: 6
TERMINAL BOOV WEIGHT: 397.0 GRAMS
DATE AND TIME OF NECROPSY: 01^24/91 7:22
PROSECTOR: KEVIN BILLINGS
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILAB
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS 1
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
1.9166 23.9939
1 3627 1.5SI5 1.5153 2.6113
.5004 X 6.0431 X
.3432 X .3926 X .3993 X .7333 X
1.0000 12.0779
.6159 .7145 .7610 1.4655
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS ` GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL C0M4ENT (GC) .........................
GROSS: -ALL TISSUES/ORQANS NORMAL
LIVER ILI 1 ...................................
MICRO: -SLIGHT
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE `PLUMP* APPEARANCE. EXCEPT FOR
THIS `ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL*.
LUNG (LU)
GROSS:
NECROPSY NOTE: TRIMMING COMMENT : LUNG NOT FOUND IN WET TISSUE AT TIME OF
TRIMMING.
MICRO: -TISSUE MISSING
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|. COAGULATING GLD (CG). LF TESTIS (TEO). PROSTATE (PR|, SEMINAL VESICLE (SV), URETHRA (UR)
qfszzoi
00
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI <329-100 PRINTED: 1S-OCT-01
PAGE: 194
ANIMAL NUMBER: C67641
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUOY DAY OF DEATH: 93
STUOY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 545.4 GRAMS
DATE ANO TIME OF NECROPSY: 03/22/91 7:57
PROSECTOR: RUTH SCHMITZ
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN IBR1 LIVER 1LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
1.9354 24.7112
1.2912 1.5795 1.6706 2.5436
.3549 X 4.5321 X
.2367 X .2996 X .3063 X .4664 X
1.0000 12.7716
.6671 .6161 .1632 1.3143
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOG KEYWORDS, SEVERITY. DISTRIBUTION
BSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER |LI) ................................... MICRO: -MINIMAL. FOCAL -MINIMAL
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP' APPEARANCE. EXCEPT FOR THIS 'ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG), L F . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV), URETHRA (UR|
O
00 CO
o
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 195
ANIMAL NUMBER: C67642
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH. 02/12/91
STUDY DAY OF DEATH. 55
STUDY WEEK OF DEATH, t
TERMINAL OOY WEIGHT . 504 7 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 7:31
PROSECTOR: KEVIN BILLINGS
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG |LU) LF. TESTIS |TED) RT. TESTIS |TE1) ACCESS/SEX ORG (SO)
2.1505 30.2501
1.475S 1.7243 1.7436 3.0769
.4261 X 5.9931 X
.2924 X .3416 X .3455 X .6096 X
1.0000 14.0869
.6863 .1011 .1101 1.4306
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * * PATHOLOG KEYWORDS. SEVERITY. DISTRIBUTION
BSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) GROSS : -ALL TISSUES/ORGANS NORMAL
LIVER ILI I MICRO: -MINIMAL
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR THIS 'ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL'.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|. COAGULATING OLD (CG). L F . TESTIS (TEO), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
CD KO
SZ200
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-OCT-B1
PAGE: 196
ANIMAL NUMBER: C67643
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/25/91
STUDY DAY OF DEATH: 96
STUOV WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 455.6 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 1:53
PROSECTOR: JACK SERFORT
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO RT. TESTIS (TE1 ACCESS/SEX ORG SO)
2.0137 17.6129
1.7374 1.7110 1.7411 3.7702
.4574 X 3.1659 X
.3113 X .3771 X .3123 X .6275 X
1.0000 1.4527
.1331 .1245 .1359 1.1094
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
IN NAME
PATHOLOGY' OBSERVATI 0 N S *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) .........................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER |LI ) ....................................
MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE 'PLUMP' APPEARANCE. EXCEPT FOR
THIS 'ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL*.
GENERAL INFORMATION (XX)
GROSS :
NECROPSY NOTE: SMALL MOVEABLE TISSUE MASS NOTED IN CLINICAL OBSERVATIONS,
INADVERTENTLY NOT COMMENTED AS TO PRESENCE OR ABSENCE AT TIME
OF NECROPSY
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). L F . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV ). URETHRA (UR)
o N fO
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-OCT-9I
PAGE: 197
ANIMAL NUMBER: C67644
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH. 02/12/91
STUDY DAY OF DEATH. SS
STUDY WEEK OF DEATH, t
TERMINAL &OOY WEIGHT: 458.2 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 1:52
PROSECTOR: KEVIN BILLINGS
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
M O A N WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BRI LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS It e m ACCESS/SEX C)RG (SO)
2.0121 21.5011
1.2512 1.1552 1.9314 3.2252
.4411 X 4.7132 X
.2743 X .4067 X .4030 X .7070 X
1.0000 10.6182
.6219 .9220 .9137 1.6029
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOG KEYWORDS. SEVERITY. DISTRIBUTION
BSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI ) .................................... MICRO: -MINIMAL. FOCAL -MINIMAL
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCVTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE `PLUMP* APPEARANCE. EXCEPT FOR THIS 'ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION. BRAIN (BR). COAGULATING OLD (CG). LF. TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|, URETHRA (UR)
o
tn
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 191
ANIMAL NUMBER: C6764S
SEX: HALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL BOOY WEIGHT: 621.6 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 6:53
PROSECTOR: DEBBIE PIRKEL
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI I LUNG |LU) LF. TESTIS 1TE0 RT TESTIS (TEI I ACCESS/SEX (JRG (SO)
2.2231 24.2640
1 6907 1.0167 2 0271 3.1797
.3576 X 3.9035 X
.2720 X .3196 X .3261 X .5115 X
1.0000 10.9111
.7603 .1934 BUS 1.4296
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
OROAN NAME
** P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) .................................... MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTR1LOBULATED PATTERN IN WHICH THE HEPATOCVTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BOROERS ARE MORE ROUNDED GIVING THE CELLS A MORE `PLUMP* APPEARANCE. EXCEPT FOR THIS 'ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD fCQ), L F . TESTIS |TE0), LUNG |LU). PROSTATE (PR). SEMINAL VESICLE (SV|, URETHRA (UR)
o
0
C/1
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTEO: 1S-OCT-91
PAGE: 199
ANIMAL NUMBER: C67646
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDY DAY OF DEATH: 57
STUDY WEEK OF DEATH: 9
TERMINAL ODY WEIGHT: 471.6 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 1:29
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOV WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR)
LIVER (LI I
LUNG (LU)
LF. TESTIS
1
F IRT. TESTIS
ACCESS/SEX (
1 SO)
2.0739 24.2562
1.7329 1.7144 1.7213 3.1011
.4333 X 5.0612 X
.3621 X .3512 X .3597 X .8410 X
1.0000 11.6959
.1356 .1267 .1300 1.4953
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOGY- OBSERVATI 0 N S *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCj GROS:i: -ALL tISSUE /ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDEO GIVING THE CELLS A MORE 'PLUMP' APPEARANCE. EXCEPT FOR THIS 'ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL' .
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CGI. L F . TESTIS (TEOI. LUNG <LU|, PROSTATE (PR|, SEMINAL VESICLE (SV). URETHRA (UR)
O
O so
N
N
C/T
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1S-0CT-B1
PAGE: 200
ANIMAL NUMBER: C67647
SEX. MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. SECONO INTERIM SACRIFICE
DATE OF DEATH: 02/14//91
STUDY DAY OF DEATH: $7
STUDY WEEK OF DEATH: 9
TERMINAL BODY WEIGHT: 432.6 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 7:30
PROSECTOR: RUTH SCHMITZ
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS 1
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR1 LIVER (LI) LUNG 1LU) LF. TESTIS (TEO) RT TESTIS ITEll ACCESS/SEX ORG (SO)
2.1070 19.S6S3
1.5717 1.6195 1.6069 2.7296
.4171 X 4.5227 X
.3633 X .3741 X .3923 X .6310 X
1.0000 9.2159
.7459 .7612 .1054 1.2955
WEIGHT TAKEN WE1QHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOG V KEYWORDS. SEVERITY. DISTRIBUTION
BSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ................................... MICRO: -MINIMAL
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE `PLUMP" APPEARANCE. EXCEPT FOR THIS `ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BRI, COAGULATING OLD (CQ). L F . TESTIS (TEO). LUNG (LU). PROSTATE |PR), SEMINAL VESICLE (SV). URETHRA (UR)
r>
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 201
ANIMAL NUMBER: C67644
SEX. HALE
DOSE GROUP: A
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL BOOT WEIGHT: 392.0 GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 7:41
PROSECTOR: KEVIN BILLINGS
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS ITE0 RT. TESTIS Itei ACCESS/SEX ()RG (SO)
2.1367 21.6322
1.40S0 1.6514 1.5671 2.6953
S451 X 5.5114 X
.3514 X .4213 X .3991 X .6176 X
1.0000 10.1241
.6576 .7729 .7334 1.2614
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOG KEYWORDS. SEVERITY. DISTRIBUTION
B S ER V AT IONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEY(S) (KD) GROSS: -LARGE PELVIS(ES) MICRO: -PRESENT
LIVER (LI| MICRO: -SLIGHT
-LEFT: BOTH COLLECTED -DILATATION.PELVIC -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTR1LOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR THIS 'ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING OLD (CG|. LF . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR|
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-81
PAGE: 202
ANIMAL NUMBER: C67649
SEX: MALE
OOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/17/91
STUDY DAY OF DEATH: 149
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 601.S GRAMS
DATE AND TIME OF NECROPSY: 05/17/91 7:07
PROSECTOR: JULIE A. LARSEN
RECOROER: JOE N. KIZZ1EE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU} LF. TESTIS (TEO) RT TESTIS ItEI ACCESS/SEX ()RG (SO)
2.1373 17.4747
1.5153 1.2237 1.9322 4.0103
.3553 X 2.9052 X
.2519 X .2034 X .3212 X .6714 X
1.0000 9.1761
.7090 .5725 .9040 1.9091
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** PATHOLOGY' O B S E R V A T I O N S
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC1 .................................. .........................
GROSS: -ALL TISSUES/ORGANS NORMAL
LF. TESTIS (TEO) ....................................................................
MICRO: -MODERATE. MULTI-FOCAL
-ATROPHY/DEGENERATION
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING GLD (CG). LIVER (LI|, LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA fUR|
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-B1
PAGE: 203
ANIMAL NUMBER: C676S0
SEX. MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUOV WEEK OF DEATH. 14
TERMINAL ODY WEIGHT: 556.3 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 9:37
PROSECTOR. RUTH SCHMITZ
RECORDER: JOE N. K1ZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR| LIVER (LI) LUNG (LU) IF TESTIS 1TEO J RT. TESTIS TE1 ACCESS/SEX ORG (SOI
2.1319 21 2076
1.7301 1.7603 1.7022 3.4461
.3132 X 5.0706 X
.3110 X .3164 X .3060 X .8200 X
1.0000 13.2312
.1115 .1257 .7984 1.6177
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOG KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC1 GROSS : -ALL TISSUES/ORGANS NORMAL
LIVER ILI) MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCVTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP' APPEARANCE. EXCEPT FOR THIS 'ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL'.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR |, COAGULATING OLD (CG), L F . TESTIS (TEO). LUNG |LU). PROSTATE |PR|. SEMINAL VESICLE (SV). URETHRA (UR|
<32200
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 19-OCT-91
PAGE: 204
ANIMAL NUMBER: C676S1
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/17/91
STUDY DAY OF DEATH. 149
STUDY WEEK OF DEATH: 22
TERMINAL 00Y WEIGHT: 614.9 GRAMS
DATE AND TIME OF NECROPSY: 05/17/91 7:41
PROSECTOR: RUTH SCHMITZ
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS ITEOI RT. TESTIS h e n ACCESS/SEX (IRQ {SO)
2.1395 20.7605
1.6295 1.1009 1.7725 3.2537
.3479 X 3.3762 X
.2641 X .2929 X .2113 X .5291 X
1.0000 9.7034
.7612 .1417 .1215 1.5209
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY' OBSERVATIONS * * *
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEY(S) (KD) .......................................... ............................................................. "
GROSS: -LARGE PELVIS(ES)
-RIGHT; BOTH COLLECTED
-SEMIFLUID MATERIAL-PELVIS
-RIGHT: FILLED WITH CLEAR FLUID
MICRO: -PRESENT
-DILATATION,PELVIC
LIVER (LI) .........................................................................................................
NECROPSY NOTE: TRIMMING COM4ENT: ONE SECTION OF LIVER MISSING FROM WET TISSUE
AT TIME OF TRIMMING
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR |, COAGULATING GLO (CG). L F . TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 20S
ANIMAL NUMBER: C876S2
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/25/91
STUDY DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL BOOV WEIGHT: S06.3 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 9:01
PROSECTOR: JACK SERFORT
RECORDER: JOE N. KIZZ1EE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO 1 RT. TESTIS tei ACCESS/SEX ORG (SO)
2.0904 21.0711
1.5510 1.1529 1.1182 4.0136
.4129 X 4.1610 X
.3063 X .3660 X .3517 X .6066 X
1.0000 10.0103
.7420 .1164 .1611 1.0535
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY' O B S E R V A T I O N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT J G C GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE *PLUMP* APPEARANCE. EXCEPT FOR THIS `ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING GLD (CG). L F . TESTIS (TEO). LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
o
ttoo
HAZLETON WISCONSIN. INC. MADISON, WISCONSIN USA
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 13-DEC-91
PAGE: 206
ANIMAL NUMBER: C67653
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/25/91
STUDY DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 592.1 GRAMS
DATE AM) TIME OF NECROPSY: 03/25/91 10:13
PROSECTOR: JACK SERFORT
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORG A N S TA TU S
BRAIN (BR1
LIVER LUNG
ILUL)I
LF. TE STli 1TE01
RT. TESTIS TEI
ACCESS/SEX ORG (SO)
2.0977 29.9513
1.9177 1.9966 1.9649 3.3919
-.3543 X 4.9739 X
.3070 X .3196 X .3150 X .5712 X
1.0000 13.7571
.9665 .9994 .9990 1.6122
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* pathology' observations
*
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) .................................... ......................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) .......................................................................................................................
MICRO: -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
-SLIGHT, FOCAL
-NECROS1S.COAGULATIVE
-MINIMAL
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM ANO THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR
THIS 'ENLARGED' APPEARANCE, THE CELLS ARE OTHERWISE 'NORMAL*.
GENERAL INFORMATION (XX) .......................................... ...........................................................
GROSS:
NECROPSY NOTE: >WART-L!KE LESION (VENTRAL HIND LEFT) NOTED IN CLINICAL
OBSERVATIONS INADVERTENTLY NOT COMMENTED ON AS TO ABSENCE OR
PRESENCE AT TIME OF NECROPSY
ioo/i
jjszzoo
HAZLETON WISCONSIN. INC. MADISON, WISCONSIN USA
APPENDIX O INDIVIDUAL ANIMAL PATHOLOOV DATA
HWI 6329-100 PRINTED: 13-DEC-91
PAOE: 207
ANIMAL NUMBER: C67653
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
OATE OF DEATH: 03/25/91
STUDY DAY OF DEATH: 96
STUOV WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 592.1 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 10:13
PROSECTOR: JACK SERFORT
RECOROER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: OR. TOM PALMER
WEIGHER: STEVE VAN ADEST1NE
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|. COAGULATING GLD (CG). L F . TESTIS (TE0|. LUNG (LU). PROSTATE (PR). SEMINAL VESICLE |SV|. URETHRA (UR)
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1S-0CT-B1
PAGE: 209
ANIMAL NUMBER: C67654
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 333.5 GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 1:11
PROSECTOR: KEVIN BILLINGS
RECORDER: VAL QUINN
POST-FIX WEIGHER. NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER. DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIOHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS ITEO) RT. TESTIS TE1 ACCESS/SEX ORG (SO)
1.9196 21 1401
1 2542 1 5679 1 5519 2.7574
.5966 X 6.3319 X
.3761 X .4701 X .4653 X .6269 X
1.0000 10.6253
.6304 .7990 .7900 1.3959
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * P A T H O L O G Y ' O B S E R V A T I O N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL C0P94ENT IOC) ..........................................................................
GROSS: -ALL TISSUES/ORQANS NORMAL
LIVER (LI) ......................................................................................................................
MICRO: -SLIGHT
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULAtED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE `PLUMP* APPEARANCE. EXCEPT FOR
THIS `ENLARGED* APPEARANCE, THE CELLS ARE OTHERWISE `NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). L F . TESTIS ITEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
o
Vorsii
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 16-OCT-B1
PAGE: 209
ANIMAL NUMBER: C6765S
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH. 02/14791
STUDY DAY OF DEATH: 57
STUDY WEEK OF DEATH: 9
TERMINAL BOOY WEIGHT: 479.5 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 1:51
PROSECTOR: RUTH SCHMITZ
RECORDER. JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO| RT. TESTIS (TEI ACCCSS/SEX ORG (SO)
2.1033 23.6742
1.6199 1.6010 1.5915 3.8047
.4316 X 4.9373 X
.3371 X .3353 X .3291 X .7511 X
1.0000 11.2557
.7702 .7645 .7519 1.7131
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOG KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT J^GC)
OSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI)
MICRO: -MINIMAL
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCVTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE "PLUMP* APPEARANCE. EXCEPT FOR
THIS "ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
URETHRA (UR) ............................. .............................................................
MICRO: -SECTION EXAMINED; TISSUE NOT PRESENT
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG), L F . TESTIS (TEO), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE |SV)
iuotn
gSZZGO
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOQY DATA
HWI 6329-100 PRINTED: 1I-0CT-B1
PAGE: 210
ANIMAL NUMBER; C678S6
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDY DAY OF DEATH: 57
STUDY WEEK OF DEATH: 9
TERMINAL BODY WEIGHT: 465.4 GRAMS
DATE AND TIME OF NECROPSY; 02/14/91 7:35
PROSECTOR: KEVIN BILLINGS
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI I LUNG |LU) LF. TESTIS (TEOl RT. TESTIS ITE11 ACCESS/SEX ORO (SO)
2.0411 21.443S
1.3111 1.9006 1.9595 2.6750
.4316 X 4.6075 X
.2914 X .4094 X .4210 X .5749 X
1.0000 10 5059
.6904 .9312 .9600 1.3106
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) .......... ......................... MICRO: -MINIMAL, FOCAL -MINIMAL
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTR1LOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR THIS "ENLARGED" APPEARANCE, THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING GLD (CG). LF . TESTIS (TEO|. LUNG (LU|, PROSTATE (PR). SEMINAL VESICLE (SV), URETHRA (UR)
fcZZGQ
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOQV DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 211
ANIMAL NUMBER: C6T65T
SEX: HALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDY DAY OF DEATH: SS
STUDY WEEK OF DEATH: I
TERMINAL BODY WEIGHT: 469.9 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 7:45
PROSECTOR: NANCY DIEDRICH
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER 1LI 1 LUNG (LU) LF. TESTIS (TEO RT. TESTIS (TEll ACCESS/SEX ()RG (SO)
2.1691 21.9155
1.5997 2.0112 1.9019 3.2793
.4616 X 6.1614 X
.3404 X .4260 X .4062 X .6977 X
1.0000 13.3629
.7375 .9272 .1100 1.5114
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY' OBSERVATIONS
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREC-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER (LI) .............................................. ........................................................................
MICRO: -MINIMAL, FOCAL
-INFILTRATES,MONONUCLEAR CELL
-MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
' ROUNDED GIVING THE CELLS A MORE `PLUMP' APPEARANCE. EXCEPT FOR
THIS `ENLARGED* APPEARANCE, THE CELLS ARE OTHERWISE "NORMAL" .
MESENTERIC LN (MSI ..............................................................................................................
GROSS: -MOTTLED
-DARK RED AND TAN (COLLECTED)
MICRO: -UNREMARKABLE
HISTOPATHOLOQICAL COMMENT: >NO MICROSCOPIC CORRELATE TO GROSS OBSERVATION.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). LF . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
oo iUon)
to
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 212
ANIMAL NUMBER: C67658
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH. 03/26/91
STUDY DAY OF DEATH. 97
STUDY WEEK OF DEATH: 14
TERMINAL BOOY WEIGHT: 444.1 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 7:59
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR| LIVER (LI) LUNG (LU) LF. TESTIS JTE) RT. TESTIS tei ACCESS/SEX ORG (SOI
2.1339 19 2416
1.5343 1.7072 1.6712 3.2944
.4605 X 4.3343 X
.3455 X .3644 X .3779 X .7416 X
1.0000 9.0204
.7160 .6000 .7864 1.5438
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y - O B S E R V A T I O N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COFMENTS / HISTOPATHOLOGIC FINDINGS
LIVER (LI | PROSTATE (PR)
...................................... ..................................
MICRO: -SLIGHT, FOCAL
-INFILTRATES.MONONUCLEAR CELL
-SLIGHT
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATEO PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BOROERS ARE MORE
ROUNDED GIVING THE CELLS A MORE `PLUMP* APPEARANCE. EXCEPT FOR
THIS `ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL'.
....................................................................................................................
GROSS: -MASS(ES)
-RIGHT SIDE: SINGLE MASS. TAN AND FIRM. 10 MM IN DIAMETER; ON
SECTION EXUDED GREEN CREAMY SEMIFLUID; COLLECTED INTACT;
REGIONAL LN (LUMBAR) NORMAL (CAP 6)
MICRO: -MODERATE. FOCAL
-INFLAMMATION. CHRONIC ACTIVE
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION. BRAIN (BR). COAGULATING OLD (CG). LF. TESTIS (TEO|, LUNG (LU). SEMINAL VESICLE (SV). URETHRA (UR)
oo iCo/i
fO
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 213
ANIMAL NUMBER: C67659
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL AOOV WEIGHT: 416.0 GRAMS
DATE AND TIME OF NECROPSY. 01/24/91 1:07
PROSECTOR: JULIE A. LARSEN
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR) LIVER (LI) LUNG (LU) LF. TESTIS 1TEO) RT. TESTIS (TEI j ACCESS/SEX <M G (SO)
2 1717 24 7761
1.6564 1.5126 1.4907 2.3142
,5237 X 5.9551 X
.3962 X .3636 X .3563 X .5563 X
1.0000 11.3720
.7603 .6943 .6642 1.0622
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) .................................... MICRO: -MODERATE. FOCAL -SLIGHT
-NECROSIS,COAGULATIVE -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP" APPEARANCE. EXCEPT FOR THIS `ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). L F . TESTIS (TEO). LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA tUR 1
'g.ZZOO
(o*1-14
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE: 214
ANIMAL NUMBER. C6T660
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. FIRST POST-RCCOV SAC
DATE OF DEATH: 05/17/91
STUDY DAY OF DEATH: 149
STUDY WEEK OF DEATH: 22
TERMINAL BOOY WEIGHT: 557.1 GRAMS
DATE AND TIME OF NECROPSY: 05/17/91 1:16
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DENNIS HOFFMAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR| LIVER (LI| LUNG (LU) LF. TESTIS ITEOI RT. TESTIS iTEl) ACCESS/SEX ORG (SO)
2.3756 20.6451
1.7257 1.7347 1.7106 3.1045
.4259 X 3.7013 X
.3094 X .3110 X .3192 X .6621 X
1.0000 6.6901
.7264 .7302 .7495 1 6015
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COTWENT JOCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR |, COAGULATING OLD (CG|. L F . TESTIS (TE0|, LIVER (LII. LUNG (LU). PROSTATE (PR|, SEMINAL VESICLE (SV|. URETHRA (UR|
con
09
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-Ol
PAGE: 215
ANIMAL NUMBER: C67661
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDY DAY OF DEATH: 55
STUDY WEEK OF DEATH: I
TERMINAL OOY WEIGHT: 412.9 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 9:22
PROSECTOR: KEVIN BILLINGS
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (ORAMS 1
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR11 LIVER (LI 1 LUNG (LU| LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2.1541 17.9125
1.4235 1.5216 1.5247 2.5619
.5217 X 4.3312 X
.3446 % .3703 X .3693 X .6222 X
1.0000 6.3155
.6606 .7097 .7076 1.1926
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC| ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER |LI) .................................... MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR THIS "ENLARGED" APPEARANCE, THE CELLS ARE OTHERWISE "NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG|. L F . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
00227
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOOV DATA
HWI 6329-100 PRINTED: ll-OCT-ttl
PAGE: 216
ANIMAL NUMBER: C67862
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH: SB
STUDY WEEK OF DEATH: 8
TERMINAL BODY WEIGHT: 431.7 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 7:50
PROSECTOR: RUTH SCHMITZ
RECORDER: RUTH SCHMITZ
POST-FIX WEIGHER. NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS TEO) RT. TESTIS (TEI ACCESS/SEX ()RG (SO)
2 0559 20.0101
1.3732 1 5417 1 5113 3.2091
.4762 X 4.6352 X
.3111 X .3517 X .3501 X .7435 X
1.0000 9.7330
.6679 .7533 .7351 1.5613
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER (LI) ....................................................................................
...............................
MICRO. -MINIMAL
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR
THIS "ENLARGED* APPEARANCE, THE CELLS ARE OTHERWISE `NORMAL*.
HANOIB/CERV LN IMN) ................................................................................................................
GROSS. -LARGE
-RIGHT: UP TO 16 X t X 6 MM (FOR COMPARISON LEFT IS 5 X 4 X 2 MM)
(CAP 6 |
MICRO: -MODERATE. FOCAL
-HYPERPLASIA. LYMPHORETICULAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). LF . TESTIS fTEOI. LUNG |LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
O in
Qo
N
HA2LETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6320-100 PRINTED: ll-OCT-01
PAGE: 217
ANIMAL NUM8ER: C67663
SEX. MALE
DOSE GROUP: 4
SACRIFICE STATUS. SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUDY DAY OF DEATH: 35
STUDY WEEK OF DEATH: S
TERMINAL BODY WEIGHT: 413.9 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 7:57
PROSECTOR: NANCY DIEDRICH
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LIi LUNG (LU) LF. TESTIS (TEO) RT. TESTIS iTEl) ACCESS/SEX ORQ (SO)
2.0214 21.1079
1.4956 1.8313 1.6523 2.3713
.4194 X 5.0999 X
.3613 X .3941 X .3992 X .5729 X
1.0000 10.4422
.7399 .9070 .9174 1.1731
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOG KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ................................... MICRO: -MINIMAL, MULTI-FOCAL -MINIMAL
-INFILTRATES,MONONUCLEAR CELL -HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTR1LOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BOROERS ARE MORE
ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR THIS 'ENLARGED* APPEARANCE, THE CELLS ARE OTHERWISE `NORMAL' .
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CO), LF. TESTIS (TEO). LUNG (LU), PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR)
o o
M
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: II-OCT-91
PAGE: 211
ANIMAL NUMBER. C67664
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/16/91
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 694.3 GRAMS
DATE AND TIME OF NECROPSY: 05/16/91 7:34
PROSECTOR: GAIL M. NOVAK
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF TESTIS ITEO) RT. TESTIS TE1 ACCESS/SEX ORG (SO)
2.1919 20.9493
2.0241 1 6121 1 6949 4.3942
.3167 X 3.0173 X
.2915 X .2424 X .2441 X .6329 X
1.0000 9.5272
.9205 .7653 .7701 1.9914
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) ......................... GROSS: -ALL T1SSUES/0RQANS NORMAL
LIVER |LI) ................................... MICRO: -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CO). LF . TESTIS (TEO). LUNG (LU|. PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MAOISM, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: it-OCT-91
PAGE: 219
ANIMAL NUMBER: C67665
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF OEATH. 01/23/91
STUDY DAY OF DEATH: 35
STUDY WEEK OF DEATH: 5
TERMINAL ODY WEIGHT: 317.1 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 9:21
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS iTElj ACCESS/SEX ORQ (SO)
2.0135 27.1119
1.5150 1.7565 1.7667 2.4346
.5192 X 7.1691 X
.3907 X .4529 X .4607 X .6276 X
1.0000 13.6475
.7524 .6724 .6674 1.2091
WEIGHT TAKEN WEIGHT TAKEN WEIGHT 1AKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY- OB SE RVATIONS *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COFWENT (OCI
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI)
MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDEO GIVING THE CELLS A MORE -PLUMP" APPEARANCE. EXCEPT FOR
THIS `ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL' .
GENERAL INFORMATION (XX)
GROSS :
NECROPSY NOTE: ANIMAL DIED PRIOR TO EXSANGUINATION
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). LF . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
tMun>
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6320-100 PRINTED: ll-OCT-91
PAGE: 220
ANIMAL NUMBER: C67666
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/17/91
STUDY DAY OF DEATH: 140
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 600.1 GRAMS
DATE AND TIME OF NECROPSY: 05/17/91 7:46
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LIi LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TEI ACCESS/SEX ()RQ (SO)
2.2312 19.4575
1.6434 1.4773 1 4605 4.0231
.3663 X 3.1945 X
.2696 X .2425 X .2396 X .6606 X
1.0000 6.7206
.7366 .6621 .6548 1.6034
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIOHT TAKEN
ORGAN NAME
PATHOLOGY- OBSERVATIONS
KEYWOROS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR), COAGULATING OLD (CQ). L F . TESTIS (TEO). LIVER (LI). LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 8329-100 PRINTED: 1I-OCT-B1
PAGE: 221
ANIMAL NUMBER: CBT8BT
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH: 56
STUOY WEEK OF DEATH: I
TERMINAL AoDY WEIGHT: 494.S GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 1:20
PROSECTOR: JULIE A. LARSEN
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE OROAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR)
LIVER (LI)
LUNG 1LU1
LF. TESTIS RT. TESTIS
1TE01 lui)
ACCESS/SEX (>RG (SO)
2 1607 25.7940
1.4690 1.6719 1.7331 3.5244
.4369 X 5.2162 X
.2971 X .3311 X .3506 X .7127 X
1.0000 11.9371
.8799 .7731 .1024 1.6311
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI GROSS. -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL. FOCAL -MINIMAL
-INFLAMMATION.GRANULOMATOUS -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCVTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR THIS 'ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). LF. TESTIS (TED). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV), URETHRA (UR)
Q&ZZGO
tn i--n*
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: IS-OCT-91
PAGE: 222
ANIMAL NUMBER: C6766I
SEX: MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUOY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 4S4.9 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 7:39
PROSECTOR: KEVIN BILLINGS
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LLIUVNEGR (L(UL)it LF. TESTIS (TEO) RT. TESTIS iTEl) ACCESS/SEX ()r g jsoi
2 .0351 14.2750
1.5259 1 6947 1.6942 2.9012
.4197 X 2.9439 X
.3147 X .3495 X .3494 X .5991 X
1.0000 7.0144
.7497 .9327 .9325 1.4290
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIONEY(S) (KD| ........................................ GROSS: -LARGE PELVIS(ES) MICRO: -PRESENT
..................... -BILATERAL -DILATATION.PELVIC
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING GLO (CG). LF TESTIS (TEO), LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
(It Oft
HAZLETON LABORATORIES AMERICA, INC. MAOISON, WISCONSIN U S A .
APPENOIX O INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 16-OCT-91
PAGE: 223
ANIMAL NUMBER: 067669
SEX'. MALE
DOSE GROUP: 4
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 523.S GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 9:20
PROSECTOR: RUTH SCHMITZ
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER. JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (8R1 LIVER (LI) LUNG ILU] LF. TESTIS ITEO) RT. TESTIS (TEI 1 ACCESS/SEX (>RG (SO)
2.0615 24.0567
1.5617 1.7125 1.7765 3.6346
.3936 X 4.5054 X
.3021 X .3405 X .3397 X .6943 X
1.0000 11.6605
.7673 .6647 .6627 1.7631
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G KEYWORDS, SEVERITY. DISTRIBUTION
B S ER V AT IONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI | .................................... MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE `PLUMP' APPEARANCE. EXCEPT FOR THIS "ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL' .
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR}. COAGULATING OLD ICG I. LF . TESTIS (TE0|. LUNG (LU|, PROSTATE (PR|, SEMINAL VESICLE (SV|, URETHRA (UR)
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1S-OCT-B1
PAGE: 224
MIMM. W . : C . , 0
J
,, ,, ,, ,, SS' ""Si! M
5sssaa*,rwws.
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO 800Y WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN IBRI LIVER (LI i LUNG ILUI LF. TESTIS ITEbl RT. TESTIS jTE1) ACCESS/SEX ORG (SO)
2.2129 24.0443
1.7924 1.9490 1.9042 4.0490
.3566 3.1750
.2119 .3139 .3069 .6525
0000 10 9655
9100 9903 9605 9297
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L O G KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVA T IO N S * GROSS FREE- TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC1 .........................
GROSS: -ALL TISSUES/ORGANS NORMAL
GENERAL INFORMATION (XX) .................
GROSS:
NECROPSY NOTE:
>SMALL MOVEABLE TISSUE MASS IVENTRAL HIND RIGHT) NOTED IN CLINICAL OBSERVATIONS, INADVERTENTLY NOT COMMENTED ON AS ABSENCE OR PRESENCE AT TIME OF NECROPSY
TO
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN CBR). COAGULATING GLD (CG), L F . TESTIS (TEO), LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-OCT-B1
PAGE: 225
ANIMAL NUMBER: C67671
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/25/91
STUDY DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL BOOY WEIGHT: 550 6 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 9:49
PROSECTOR: JACK SERFORT
RECORDER: JOE N. KIZZ1EE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORO (SO)
2 2213 2 9610
1.7199 1.9706 1 9721 3.5017
.4047 X 5.2599 X
.3122 X .3579 X .3512 X .6373 X
1.0000 12.9969
.7714 .9144 .9950 1.5746
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * P A T H O L O G V' O B S E R V A T I O N S *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (QC) GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL, FOCAL -SLIGHT
-INFILTRATES.MONONUCLEAR CELL HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR THIS 'ENLARGED* APPEARANCE, THE CELLS ARE OTHERWISE `NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). L F . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE |SV), URETHRA (UR)
ro
N-
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX 0 INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 18-OCT-91
PAGE: 226
ANIMAL NUMBER: C6T6T2
SEX: MALE
DOSE GROUP: S
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/25/01
STUDY DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 459.5 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 7:20
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. KI2ZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
8RAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS TEO RT. TESTIS (TEll ACCESS/SEX (m o (so)
2.1400 20.0120
1.4046 1.6796 1.6773 3.3349
.4657 X 4.3704 X
.3057 X .3655 X .3650 X .7251 X
1.0000 9.3941
.6564 .7149 .7131 1.5514
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
BSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ................................... MICRO: -MINIMAL. MULTI-FOCAL -MINIMAL
INFILTRATES,MONONUCLEAR CELL -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP' APPEARANCE. EXCEPT FOR
THIS `ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). LF . TESTIS (TE0|. LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
o
in
fOs
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 16-OCT-B1
PAGE: 227
ANIMAL NUMBER: C67673
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL BOOY WEIGHT: SOI.I GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 7:14
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL BEVAN
POST-FIX WEIGHER NOT AVAILABLE
PATHOLOGIST: OR. TOM PALMER
WEIGHER: JOE N. K1ZZ1EE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR I LIVER fLI :1 LUNG (LU) LF. TESTIS (TE01 RT. TESTIS CTEI I ACCESS/SEX ORG (SO)
2.3361 23 3503
1.5036 1.7336 1 7065 3.3136
.4657 X 4.6533 X
.2996 X .3455 X .3405 X .6743 X
1.0000 9.9924
.6434 .7419 .7311 1.4410
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* ** PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC } ......................... GROSS. -ALL USSUES/ORGANS NORMAL
LIVER (LI) ................................... MICRO. -SLIGHT
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM ANO THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE "PLUMP* APPEARANCE. EXCEPT FOR THIS "ENLARGEO" APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLO (CG) . L F . TESTIS (TEO), LUNG (LU). PROSTATE |PR). SEMINAL VESICLE (SV|, URETHRA (UR)
O
05
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN US.A.
APPENDIX O INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1S-0CT-91
PAGE: 22S
ANIMAL NUMBER: C67674
SEX: MALE
DOSE GROUP. 5
SACRIFICE STATUS: SCHEDULED, FIRST POST-RECOV SAC
DATE OF DEATH: OS/16/91
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 22
TERMINAL BOOY WEIGHT. 6SS.4 GRAMS
OATE AND TIME OF NECROPSY: OS/16/91 1:51
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X )
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR| LIVER jLI 1 LUNG | LU) LF. TESTIS CTE01 RT. TESTIS TE1 ACCESS/SEX ORO ISO)
2.2179 21.6330
1.6911 1.9654 1.9013 3.9142
.3394 X 3.3007 X
.2590 X .2999 X .2912 X .5972 X
1.0000 9.7543
.7625 .9962 .9604 1.7649
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * P A T H O L O GY- O B S E R V A T I O N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
MANDIB/CERV LN (MN1 .......... GROSS : -LARGE MICRO: -MODERATE, MULTI-FOCAL
-BILATERAL: EACH IS UP TO 15 X 10 X 5 MM; COLLECTED -HYPERPLASIA, LYMPHORETICULAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR) . COAGULATING OLD (CG). LF. TESTIS ( TEO) ,. LIVER (LI), LUNG (LU| . PROSTATE (PR). SEMINAL VESICLE |SV), URETHRA |UR)
r> N
QG
Urroo1
HAZLETON LABORATORIES AMERICA. INC MADISON. WISCONSIN U S A
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 19-OCT-91
PAGE: 229
ANIMAL NUMBER: C67675
SEX: MALE
DOSE GROUP. S
SACRIFICE STATUS. SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL ODY WEIGHT: 401.9 GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 7:19
PROSECTOR: DENNIS HOFFMAN
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOOIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (8R) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RTfrESTIS (TElj ACCESS/SEX ORG (SO)
2.0451 29.9112
1 4415 1.5379 1.5979 2.7515
.5003 X 7.3169 X
.3525 X .3761 X .3993 X .6729 X
1.0000 14.6242
.7046 .7517 .7761 1.3450
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) ................................... ,, .......................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ......................................................................................................................
MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATEO PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BOROERS ARE MORE
ROUNDED GIVING THE CELLS A MORE `PLUMP' APPEARANCE. EXCEPT FOR
THIS `ENLARGED' APPEARANCE, THE CELLS ARC OTHERWISE `NORMAL'.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING GLD ICO I. L F . TESTIS |TE0). LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
gszzoo
(Mn
CO
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-B1
PAGE: 230
ANIMAL NUMBER: C67676
SEX: MALE
DOSE GROUP: S
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/17/91
STUDY DAY OF DEATH: 149
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 399.4 GRAMS
DATE AND TIME OF NECROPSY: 05/17/91 1:37
PROSECTOR: DEBBIE PIRKEL
RECORDER: JOE N. KIZ2IEE
POST-FIX WEIGHER. NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DENNIS HOFFMAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER jLI) LUNG (LU) LF. TESTIS ITEOII RT. TESTIS Ite i ! ACCESS/SEX ()RG ISO)
2 2129 15 9177
1 6120 1 7404 1 6794 4 5674
.5541 X 3.9154 X
.4036 X .4351 X 4205 X 1.1436 X
1.0000 7.1931
.7265 .7165 .7519 2.0640
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L O G V KEYWORDS. SEVERITY. DISTRIBUTION
OSSERVATI 0 N S * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) .................................. .................................... ...................................
GROSS: -ANIMAL THIN
LUMBAR/ILIAC LN JLM) ..............................................................................................................
GROSS: -LARGE
-BILATERAL: UP TO 20 X 10 X 5 MM(CAP 6 1
MICRO: -SLIGHT, MULTI-FOCAL
-HYPERPLASIA. LYMPHORETICULAR CELL
PROSTATE (PR| ......................................................................................................................
GROSS: -MASS(ES)
-INVOLVING ENTIRE PROSTATE: SINGLE MASS, 20 X 20 X 10 MM. RED
TAN, SOFT AND GELATINOUS: SAME ON CUT SURFACE: COLLECTED INTACT:
REGIONAL LN (SEE LUMBAR]
MICRO: -SEVERE, MULTI-FOCAL
-INFLAMMATION. CHRONIC ACTIVE
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CO). L F . TESTIS |TEO). LIVER tLl), LUNG |LU). SEMINAL VESICLE fSVJ. URETHRA (UR)
O (!)
ON
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-Ol
PAGE: 231
ANIMAL NUMBER: C67877
SEX: MALE
DOSE GROUP: S
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT. 532.1 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 9:04
PROSECTOR: DEBBIE P1RKEL
RECORDER: TILL SEVAN
POST-FIX WEIGHER: NOT AVAILAB LE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN IBM 1 LIVER 1LIi LUNG (LU) LF. TESTIS (T01 RT. TESTIS TEI ACCESS/SEX ORG (SO)
2.1273 23.0049
1.4376 1.6225 1.6322 2.6019
.3996 X 4.3234 X
.2702 X .3049 X .3067 X .4690 X
1.0000 10.6141
.6756 .7627 7673 1.2231
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOQ KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL. FOCAL -MINIMAL
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR
THIS 'ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR), COAGULATING GLD |CG), L F . TESTIS (TEO). LUNG (LU). PROSTATE (PR|. SEMINAL VESICLE (SV). URETHRA (UR)
oO
in
rcon
N
N
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-Si
PAGE: 232
ANIMAL NUMBER: C6767I
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/16/91
STUDY DAY OF DEATH: 148
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 552.5 GRAMS
DATE AND TIME OF NECROPSY: 05/16/91 8:59
PROSECTOR: DEBBIE PIRKEL
RECOROER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI LUNG (LU) LF. TESTIS (TEO]1 RT TESTIS (TE1|I ACCESS/SEX ORG I[SOI
2 0649 19 4957
1 4101 1.7275 1.7204 3.6056
.3737 X 3.5286 X
.2552 X .3127 X .3114 X .6528 X
I.0000 0.4415
.6829 .8366 .8332 1.7461
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* ** PATHOLOGY' OSSERVATI 0 NS **
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT 1GC) GROSS: -ALL TISSUES/ORQANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). L F . TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE |SV|. URETHRA (UR)
tn
O o%
N
8A
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-OCT-91
PAGE: 233
ANIMAL NUMBER: C6T6T9
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS. SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUOY WEEK OF DEATH: 14
TERMINAL ODY WEIGHT: 437.4 GRAMS
DATE AND TIME OF NECROPSY 03/22/91 9:01
PROSECTOR: RUTH SCHMITZ
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI| LUNG (LU) LF. TESTIS ITEOl RT. TESTIS (TEI ACCESS/SEX <)RG jSO)
2.0367 21.2020
1.5392 1.8515 1.7670 3.0514
.4656 X 6.4476 X
.3519 X .4233 X .4040 X .8992 X
1.0000 13.1469
.7557 .9091 .1876 1.5016
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
KIDNEYfS) (KDl GROSS: -LARGE PELVIS)ES) MICRO: -PRESENT
LIVER ILI) MICRO: -SLIGHT
-RIGHT: BOTH COLLECTED -DILATATION,PELVIC -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTR1LOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE `PLUMP' APPEARANCE. EXCEPT FOR
THIS `ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL'.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). L F . TESTIS (TEO), LUNG |LU), PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR)
O tron Q 0 ?0
ip
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1S-OCT-01
PAGE: 234
ANIMAL NUMBER: C67660
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDY DAY OF DEATH: 55
STUDY WEEK OF DEATH: I
TERMINAL BODY WEIGHT: 430.9 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 1:42
PROSECTOR: NANCY DIEDRICH
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI{ LUNG |LU) LF. TESTIS (TEO) RT. TESTIS Ite i { ACCESS/SEX ()RG (SO)
2 0122 30.3922
1.5506 1.5517 1.5216 2.9374
.4670 X 7.0532 X
.3599 X .3617 X .3531 X .6595 X
1.0000 15.1040
.7706 .7746 7562 1.4101
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT ]GC GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -SLIGHT
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBUlAteD PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP' APPEARANCE. EXCEPT FOR THIS `ENLARGED' APPEARANCE, THE CELLS ARE OTHERWISE `NORMAL' .
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATINO OLD |CG), LF . TESTIS (TEO). LUNG |LU|. PROSTATE (PR). SEMINAL VESICLE (SV|, URETHRA (UR)
r> o fU% 2 0 GO 20
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 235
ANIMAL NUMBER: C676I1
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 372.9 GRAMS
DATE AND TIME OF NECROPSY. 01/25/91 7:12
PROSECTOR: JULIE A. LARSEN
RECORDER: JACK SERFORT
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN IBR) LIVER (Lll LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TEI ACCESS/SEX (>rg jso)
2.0276 25.911
1.4507 1.62(2 1.6029 2.7151
.5437 X 6.9417 X
.3190 X .4366 X .4291 X .7261 X
1.0000 12.7795
.7155 .030 .7905 1.3391
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) GROSS : -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL, MULTI-FOCAL -SLIGHT
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR THIS `ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL'.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR). COAGULATING OLD (CG), LF . TESTIS (TEO). LUNG |LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
o U1
o
fS>
so
10
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE. 236
ANIMAL NUMBER. C676I2
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/81
STUDY DAY OF DEATH: 35
STUDY WEEK OF DEATH: 5
TERMINAL BODY WEIGHT: 373.0 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 7:11
PROSECTOR: NANCY DIEDRICH
RECORDER: JILL SEVAN
POST-FIX WEIGHER. NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1} ACCESS/SEX ORG (SO)
2.1455 26.9282
1.3795 1 5366 1 5994 2.1357
.5752 X 7.2111 X
.3691 X .4120 X .4291 X .7602 X
1.0000 12.5501
.6430 .7162 .7455 1.3217
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI ......................... GAOSS: -ALL TISSUES/ORGANS NORMAL
LIVER |LI) ................................... MICRO: -SLIGHT
HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTR1L0BULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE `PLUMP" APPEARANCE. EXCEPT FOR THIS "ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CO). L F . TESTIS |TEO), LUNG ILU), PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED. 1I-OCT-B1
PAGE: 237
ANIMAL NUMBER: C67693
SEX: MALE
DOSE GROUP: S
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF OEATH: 05/16/91
STUDY DAY OF DEATH: 141
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 593 0 GRAMS
DATE AND TIME OF NECROPSY: 05/16/91 6:02
PROSECTOR: GAIL M. NOVAK
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR|1 LIVER }LIj1 LUNG (LU) LF. TESTIS (TE01 RT TESTIS (TE1 ACCESS/SEX ORG (SOI
2.1457 17.4511
1 5412 1.5634 1.5733 3.6391
.3616 X 29441 X
.2596 X .2636 X .2653 X .6137 X
1.0000 6 1366
.7163 .7266 .7332 1.6960
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y KEYWORDS. SEVERITY, DISTRIBUTION
O B S E R V A T I O N S GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI ........................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
liver a n
..................................................................................
MICRO: -SLIGHT, FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR |, COAGULATING OLD (CGI. LF . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR|
o in N <A> N
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOQV DATA
HWI 6329-100 PRINTED. 1t-OCT-91
PAGE: 23t
ANIMAL NUMBER: C 6 7 6 M
SEX: MALE
DOSE GROUP: S
SACRIFICE STATUS: SCHEDULED, FIRST POST-RECOV SAC
DATE OF DEATH: 05/17/91
STUDY DAY OF DEATH: 149
STUDY WEEK OF DEATH: 22
TERMINAL BOOY WEIGHT: 490.9 GRAMS
DATE AND TIME OF NECROPSY: 05/17/91 1:11
PROSECTOR: DEBBIE PIRKEL
RECORDER: JOE N. KI2ZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER. DENNIS HOFFMAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE11 ACCESS/SEX ORG (SO)
2 0711 14.1733
1.4S41 1 6550 1.7131 2.4774.
4219 X 26*72 X
2962 X .3371 X .3491 X .5047 X
1.0000 6.1434
.7021 .7991 .1275 1.1962
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
O B S E R V A T I O N S * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR ) COAGULATING OLD (CG), LF. TESTIS (TE0|. LIVER (LI|, LUNG (LU), PROSTATE (PR|, SEMINAL VESICLE (SV). URETHRA |UR)
O o
N Ut
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE: 239
ANIMAL NUMBER: C676IS DATE OF DEATH: 01/16/91
SEX: MALE STUDY DAY
OF
DEATH:
DOSE GROUP: 5 21 STUOY WEEK
OFSADCERAITFHI:CE4
STATUS:
UNSCHEDULED |M) TERMINAL BOOY WEIGHT:
NOT
ENTERED
DATE AND TIME OF NECROPSY: 01/16/91 13:30
PROSECTOR: DEBBIE PIRKEL
RECORDER: DEBBIE PIRKEL
POST-FIX WEIGHER. NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: NOT AVAILABLE
*** ANIMAL HAS NO ORGAN WEIGHTS RECORDED
ORGAN NAME
** P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER (LI)
MICRO: -SLIGHT. FOCAL -MINIMAL
SKIN (SK)
GROSS: -ABRASION!S|/ULCERATION(S ) MICRO: -SEVERE, FOCAL
-SEVERE, FOCAL
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDEO GIVING THE CELLS A MORE `PLUMP* APPEARANCE. EXCEPT FOR THIS `ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL*. -BILATERAL. CERVICAL REGION: TWO TAN AND RED ABRADED AREAS. ONE IS 25 X 10 MM AND THE OTHER IS 15 X 10 MM (CAP 6) -DERMATITIS -ULCERATION
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR). COAGULATING OLD (CG). LF . TESTIS (TEO), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR|
r>
N
Ul uutt
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 240
ANIMAL NUMBER. C67668
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL BOOY WEIGHT: NOT ENTERED
DATE AND TIME OF NECROPSY: 03/22/91 7:22
PROSECTOR: KEVIN BILLINGS
RECORDER: JOE N. KIZZ1EE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BRI LIVER (LI) LUNG ILU) LF. TESTIS |TEO) RT. TESTIS ITE1 ACCESS/SEX ORG (SOI
2.1931 25.9462
1.6253 1.9943 1.6261 3.1612
1.0000 11.1317
.7411 .1592 .6330 1.4414
EXCLUDE EXCLUDE EXCLUDE EXCLUDE EXCLUDE EXCLUDE
ORGAN NAME
** PATHOLOG KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER ILI) MICRO: -MINIMAL. FOCAL -SLIGHT
GENERAL INFORMATION (XX) GROSS :
NECROPSY NOTE:
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM ANO THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR
THIS "ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL" . >800Y WEIGHT INADVERTENTLY NOT TAKEN PRIOR TO EXSANGUINATION
THEREFORE. ANIMAL WAS EXCLUDED FROM STATISTICAL ANALYSIS
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CO). L F . TESTIS (TEO). LUNG |LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
o ro
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 18-OCT-91
PAGE: 241
ANIMAL NUMBER: C67667
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 313.1 GRAMS
DATE ANO TIME OF NECROPSY: 01/25/91 7:30
PROSECTOR: JULIE A. LARSEN
RECORDER: JACK SERFORT
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR|1
LIVER LUNG
|LI |LU)
1
LF. TESTIS (TEO)
RT. TESTIS iTEI
ACCESS/SEX ORO (SO)
2.2291 22.9772
1 4440 1 5960 1.7054 2.4616
.5119 X 5.9977 X
.3769 X .4168 X .4452 X .8425 X
1.0000 10.3071
.8478 .7160 .7651 1.1043
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L O G KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI I ................................... MICRO: -SLIGHT
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP" APPEARANCE. EXCEPT FOR THIS `ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|, COAGULATING OLD (CG). LF . TESTIS (TEO). LUNG (LU). PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR)
n
e iiunn>
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 18-OCT-91
PAGE: 242
ANIMAL NUMBER: C67688
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/28/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 412.5 GRAMS
DATE ANO TIME OF NECROPSY: 03/26/91 8:14
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEOI RT. TESTIS 1TE1) ACCESS/SEX ORG (SO)
2.2203 25.7541
1.4103 1.5410 1.6223 2.3141
.5393 X 62434 X
.3419 X .3736 X .3933 X .5790 X
1.0000 11.5994
.6352 .6941 .7307 1.0739
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT JOC) .........................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER |LI) ...................................
MICRO: -SLIGHT
-HYPERTROPHY. HEPATOCELLULAR. CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BOROERS ARE MORE
ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR
THIS -ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE -NORMAL".
GENERAL INFORMATION (XX)
GROSS:
NECROPSY NOTE': ANIMAL DIED PRidR TO EXSANGUINATION; BLOOD SAMPLE COLLECTED
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG), L F . TESTIS |TEO). LUNG (LU). PROSTATE (PR ). SEMINAL VESICLE (SV). URETHRA (UR)
C023Q
ucCnOt
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 18-OCT-91
PAGE: 243
ANIMAL NUMBER: C676I9
SEX: MALE
DOSE GROUP: S
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUDY DAY OF DEATH: 35
STUOV WEEK OF DEATH: 5
TERMINAL BODY WEIGHT: 392.4 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 9:32
PROSECTOR. JULIE A. LARSEN
RECORDER. JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORQ (SO)
2 0011 27 4930
1.4362 1.4394 1.4376 2.2316
.5101 X 7.0064 X
.3660 X .3666 X .3664 X .5705 X
1.0000 13.7341
.7175 .7191 .7163 1.1164
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOG KEYWORDS. SEVERITY. DISTRIBUTION
BSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL CO*NT IGC) .........................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI| ...................................
MICRO: -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
-MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR
THIS "ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
GENERAL INFORMATION (XX)
GROSS :
NECROPSY NOTE: ANIMAL DIED PRIOR TO EXSANGUINATION
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). L F . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
"TOC20D
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1S-0CT-91
PAGE. 244
ANIMAL NUMBER: C67S90
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUDY DAY OF DEATH. 35
STUDY WEEK OF DEATH: 5
TERMINAL BODY WEIGHT: 365.2 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 7:44
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER ILIl LUNG (LU) LF. TESTIS (TEO) RT. TESTIS TE1 ACCESS/SEX ORG (SO)
1.9734 25.5643
1.4011 1.5479 1.5556 2.4551
.5404 X 7.0001 X
.3837 X .4231 X .4260 X .6723 X
1.0000 12.9544
.7100 .7344 .7333 1.2441
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) .................................................................................. .................
GROSS: -ALL TISSUES/ORQANS NORMAL
LIVER |LI) ......................................................................................................................
MICRO: -SLIGHT, MULTI-FOCAL
-INFILTRATES.MONONUCLEAR CELL
-SLIGHT
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE "PLUMP* APPEARANCE. EXCEPT FOR
THIS "ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR). COAGULATING OLD (CG), IF. TESTIS (TEO). LUNG (LU), PROSTATE (PR }. SEMINAL VESICLE (SV). URETHRA (UR)
uu0i0>
CO
to*
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-tl
PAGE: 245
ANIMAL NUMBER: C67691
SEX: MALE
DOSE GROUP: S
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF OEATH. 03/25/91
STUDY DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 405.9 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 7:39
PROSECTOR: JACK SERFORT
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1 ACCESS/SEX ()RQ (SO)
1.9935 19 6479
1.2919 1.5029 1.4099 2.9957
.4911 X 4.9406 X
.3200 X .3703 X .3471 X .7109 X
1.0000 9.9559
.6516 .7539 .7087 1.4476
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) GROSS : -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -SLIGHT
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDEO GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR THIS "ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL" .
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). IF TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|, URETHRA (UR)
r>
Q
N Q
UU(a1>)
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 246
ANIMAL NUMBER: C67692
SEX: MALE
DOSE GROUP. 5
SACRIFICE STATUS. SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL BOOY WEIGHT: 390.9 GRAMS
OATE AND TIME OF NECROPSY: 01/24/91 9:20
PROSECTOR: DENNIS HOFFMAN
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR| LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2 0512 26.0919
1 6213 1.T223 1 7144 2.1217
.5247 X 6.6749 X
.4149 X .4406 X .4396 X .7219 X
1.0000 12.7203
.7904 .9397 .9359 1.3756
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ................................... MICRO: -MINIMAL, FOCAL -MINIMAL
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE -PLUMP* APPEARANCE. EXCEPT FOR THIS `ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). LF . TESTIS (TEO), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX O INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 247
ANIMAL NUMBER: C67693
SEX: MALE
DOSE GROUP: S
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 402.0 GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 6:44
PROSECTOR: DENNIS HOFFMAN
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE P1RKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG 1LU} LF. TESTIS (TEO) RT. TESTIS (TEI 1 ACCESS/SEX ()RG (SO)
2.0524 22.4973
1.4325 1.5361 1.5114 3.1217
.5105 X 5.5963 X
.3563 X .3121 X .3760 X .7713 X
1.0000 10.9615
.6910 .7464 .7364 1.5244
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT GROS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -SLIGHT
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRllOBULATED PATTERN IN WHICH THE HEPATOCVTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR THIS 'ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR), COAGULATING GLD (CG). LF . TESTIS (TEO), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 241
ANIMAL NUMBER: C67694
SEX: MALE
DOSE GROUP: S
SACRIFICE STATUS: SCHEDULED, FIRST POST-RECOV SAC
DATE OF DEATH: 05/16/91
STUDY DAY OF DEATH: 141
STUOY WEEK OF DEATH: 22
TERMINAL 00V WEIGHT : 595, T GRAMS
DATE ANO TIME OF NECROPSY: OS/16/91 9:09
PROSECTOR: GAIL M. NOVAK
RECORDER: JOE N. KIZZ1EE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER. JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER jLI{ LUNG (LU) LF. TESTIS (TEO]1 RT. TESTIS TE1 ACCESS/SEX ORG |SO)
2.2711 20.0263
1.7747 1.1411 1.7216 4.1212
3125 X 3.3611 X
.2979 X .3091 X .2902 X .6911 X
1.0000 1.7111
.7711 .1079 .7516 1.1015
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WE10HT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O LO G Y O B S E R V A T I 0 N S *
KEYWOROS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC1 ........................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ..................................................................................
MICRO: -MINIMAL. MULTI-FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG|, LF. TESTIS (TEO). LUNG <LU|, PROSTATE (PR|. SEMINAL VESICLE (SV|. URETHRA (UR|
$0E2G3
r
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 18-OCT-91
PAGE: 249
ANIMAL NUMBER: C67695
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 315 9 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 7:27
PROSECTOR: RUTH SCHMITZ
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN IBR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS 1TE1) ACCESS/SEX ORG (SO)
2.1119 21.7197
1.3370 1.1195 1.7250 3.0418
.5491 X 5.6465 X
.3465 X .4715 X .4470 X .7900 X
1.0000 10.2135
.6310 .1567 .1141 1.4369
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER lLI | .................................... MICRO: -SLIGHT
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE `PLUMP* APPEARANCE EXCEPT FOR THIS `ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR). COAGULATINO OLD ICG), L F . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: li-OCT-91
PAGE: 250
ANIMAL NUMBER: C67696
SEX: MALE
DOSE GROUP: S
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OP DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 350.6 GRAMS
DATE At TIME OF NECROPSY. 01/24/91 7:39
PROSECTOR: DENNIS HOFFMAN
RECORDER: VAL QUINN
POST-FIX WEIGHER NOT AVAILABLE
PATHOLOQIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI 1 LUNG (LU) LF. TESTIS (TEOI RT. TESTIS (TE1{ ACCESS/SEX ORG SO)
1.1946 24.1013
1.2521 1.0194 1.5899 2.3663
.5404 X 7.0780 X
.3573 X .3107 X .4471 X .6749 X
1.0000 13.0942
.6612 .5750 .1266 1.2490
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT. TAKEN
ORGAN NAME
** PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEY|S) (KD) ....................... GROSS: -LARGE PELVIS(ES) MICRO: -PRESENT
IF. TESTIS (TEOI ..................... GROSS; -CONTAINS FLUID MICRO: -MODERATE. DIFFUSE
LIVER (LI| ........................... MICRO: -MODERATE, FOCAL -MINIMAL
-BILATERAL: BOTH COLLECTED -DILATATION.PELVIC -LEFT: CLEAR FLUID -ATROPHY/DEGENERATION -NECROSIS.COAGULATIVE -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR THIS "ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE -NORMAL".
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1S-OCT-91
PAGE: 251
ANIMAL NUMBER: C6T696
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF OEATH: 6
TERMINAL BODY WEIGHT: 350.6 GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 7:39
PROSECTOR: DENNIS HOFFMAN
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING GLD (CG). LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
(PTCZGO
wi4nk
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 19-OCT-91
PAGE: 252
ANIMAL NUMBER: C67997
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/29/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL BOOY WEIGHT: 491.7 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 7:49
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR) LIVER (LI) LUNO fLU) LF. TESTIS 1TEO) RT. TESTIS (TEI) ACCESS/SEX ORG (SO)
2.1143 30.4173
1.4679 1.9159 1.9220 4.1309
.4399 X 6.3148 X
.3047 X .3770 X .3792 X .9575 X
1.0000 14.3965
.6943 .9599 .9619 1.9537
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOG KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER lLI) .................................... MICRO: -MINIMAL. FOCAL -SLIGHT
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE `PLUMP' APPEARANCE. EXCEPT FOR THIS `ENLARGED- APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL' .
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |8R), COAGULATING GLD |CG). L F . TESTIS (TEO). LUNG |LU|, PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA |UR |
flEZO
in er>
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 18-OCT-91
PAGE : 253
ANIMAL NUMBER: C67696
SEX: HALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH. 37
STUDY WEEK OF DEATH: 6
TERMINAL OOY WEIGHT: 319 6 GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 7:33
PROSECTOR: NANCY DIEDRICH
RECORDER: JACK SERFORT
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS 1
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (XI
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN LIVER
((LBlR||11
LUNG |LU)
LF. TESTIS (TEO)
RT. TESTIS ITE1
ACCESS/SEX ORG (SOI
2 0041 23.9691
1 3563 1.6596 1.6212 2.6625
.5144 X 6.1522 X
.3466 X .4260 X .4161 X .7347 X
1.0000 11.9600
.6776 .6262 .6069 1.4263
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G KEYWORDS. SEVERITY. DISTRIBUTION
BSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEY!S I (KD) GROSS: -LARGE PELVIS!ESI -SEMIFLUID MATERIAL-PELVIS MICRO: -PRESENT
LIVER (LI) MICRO: -SLIGHT. FOCAL -SLIGHT
-LEFT; BOTH KIDNEYS COLLECTED -LEFT: FILLED WITH CLEAR FLUID; BOTH KIDNEYS COLLECTED -DILATATION.PELVIC -NECROSIS.COAGULATIVE -HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNOED GIVING THE CELLS A MORE "PLUMP* APPEARANCE. EXCEPT FOR
THIS "ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR). COAGULATING OLD (CG). LF TESTIS (TEO). LUNG (LU|. PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA |UR|
O
O 0 CO
^4
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 254
ANIMAL NUMBER: C67699
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDY DAY OF DEATH: 57
STUOY WEEK OF DEATH: 9
TERMINAL BODY WEIGHT: 451.9 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 1:03
PROSECTOR: RUTH SCHMITZ
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT 1GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TEI I ACCESS/SEX ()RG (SO)
1.9112 23 8952
1.6440 1.7*74 1 6750 2.5243
.43*4 X 5.2412 X
.3631 X .3955 X .3707 X .5516 X
1.0000 11.9550
.1291 .9022 .1454 1.2741
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIOHT TAKEN
ORGAN NAME
** * PATHOLOG KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) .................................... MICRO: -MINIMAL. FOCAL -SLIGHT
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULAtED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE `PLUMP' APPEARANCE EXCEPT FOR THIS `ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE -NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN 1BR), COAGULATING GLD (CG). L F . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE |SV), URETHRA (UR)
in
N CD CJ
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HUI 6329-100 PRINTED: lt-OCT-Bl
PAGE: 2SS
ANIMAL NUMBER: C67700
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/25/91
STUDY DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 551.6 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 7:21
PROSECTOR: JACK SERFORT
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIOHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG |LU) LF. TESTIS (TEO) RT. TESTIS (TEI ACCESS/SEX ()RG (SO)
2.0545 34.0432
1.7753 2.0474 1.9514 4.1521
.3671 X 6.0944 X
.3171 X .3665 X .3506 X .7434 X
1.0000 16.5701
.1641 .9965 .9532 2.0213
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L O G KEYWORDS, SEVERITY. DISTRIBUTION
BSERVATIONS * GROSS FREE-TEXT COM4ENTS / HISTOPATHOLOGIC FINDINGS
GENERAL C0M4ENT (GCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER |LI) .................................... MICRO: -SLIGHT
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE `PLUMP* APPEARANCE. EXCEPT FOR THIS `ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CO). LF . TESTIS (TEO), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 2S6
ANIMAL NUMBER: C67701
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH. 05/16/91
STUOY DAY OF DEATH: 141
STUDY WEEK OF DEATH. 22
TERMINAL ODY WEIGHT: 541.9 GRAMS
DATE AND TIME OF NECROPSY: 05/16/91 9:04
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN IBRI LIVER (LI) LUNG (LU) LF. TESTIS (TEO RT. TESTIS TE1 ACCESS/SEX ORG SO)
2.0221 19.0210
1.6734 1 7353 1.7266 4.9046
.3733 X 3.5120 X
.3019 X 3203 X 3197 X .9969 X
1.0000 9.4069
.9273 .9579 .9536 2.3752
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
IN NAME
* PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATI 0N S ** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COW4ENT IOC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR|. COAGULATING GLD (CG). LF TESTIS (TEO), LIVER (LI). LUNG (LU). PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-61
PAGE: 2S7
ANIMAL NUMBER: C67702
SEX: MALE
DOSE GROUP: S
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE DATE
OAFND.DETAITMHE: OF02/N1EC3Sl/RIC9O1PSV:
STUDY DAY OF DEATH: 56
STUDY WEEK OF DEATH:
02/13/91 1:41
PROSECTOR: DENNIS HOFFMAN
I
TERMINAL BOOT WEIGHT: 462. GRAMS RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN IBR1 LIVER (LI) LUNG ILlii LF. TES u s (TEO) RT. TESTIS tei ACCESS/SEX ORO (SO)
1.9730 25.0007
1.7193 1.5536 1.5152 3.1093
.4263 X 5.4021 X
.3715 X .3357 X .3274 X .6711 X
1.0000 12.6714
.1714 .7174 .7610 1 5759
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L O G Y KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI ) .................................... MICRO: -MINIMAL
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBUlAt ED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE `PLUMP* APPEARANCE. EXCEPT FOR THIS `ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN 10R). COAGULATING OLD (CG). LF TESTIS (TEO). LUNG (LU), PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR)
O O
tunv
0
to
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE: 251
ANIMAL NUMBER C67703
SEX: MALE
DOSE GROUP. 5
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDY DAY OF DEATH: 57
STUOY WEEK OF DEATH: 9
TERMINAL BOOY WEIGHT: 473.9 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 7:52
PROSECTOR: RUTH SCHMITZ
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME BRAIN (BR) LIVER |LIi LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
ABSOLUTE ORGAN WEIGHT (GRAMS 1 2.1139 27.2361 1.6909 1.7440 1.6116 3.1259
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X| .4461 X 5.7472 X .356 X .3660 X .3541 X .6596 X
ORGAN TO BRAIN WEIGHT RATIO 1.0000 12.1843 .7999 .1250 .7955 1.4717
ORGAN' STATUS WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOG KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI I .................................... MICRO: -SLIGHT
URETHRA (UR| MICRO. -SECTION EXAMINED; TISSUE NOT PRESENT
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR THIS "ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL"
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (8R). COAGULATING OLD (CG). LF . TESTIS (TEO), LUNG (LU), PROSTATE (PR). SEMINAL VESICLE (SV|
M C4
Si
UuN!t
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 2S9
ANIMAL NUMBER: C67704
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/17/91
STUDY DAY OF DEATH: 149
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 597.4 GRAMS
DATE AND TIME OF NECROPSY: 05/17/91 1:17
PROSECTOR: RUTH SCHMITZ
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DENNIS HOFFMAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BRI LIVER (LI) LUNG (LU) LF. TESTIS (TEO 1 RT. TESTIS Itei I ACCESS/SEX ()RG (SO)
2 0053 19.9150
1.5215 1 6107 1.6761 3.0951
ORGAN NAME
* PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
.3357 X 3.3453 X
.2559 X .2696 X .2(06 X .5112 X
1.0000 9.9661
.7622 (032 .1351 1.5431
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
OSSERVATI 0 N S
`
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC GROS!5: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBRI. COAGULATING GLD (CG). L F . TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
Stczoo
wwin
>
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE. 260
ANIMAL NUMBER: C6770S
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH: 58
STUDY WEEK OF DEATH: I
TERMINAL BODY WEIGHT: 418.6 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 9:14
PROSECTOR: JULIE A. LARSEN
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BRI LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TEI ACCESS/SEX ()RG (SO)
2.0659 26.4625
1.5050 1.6570 1.5956 2.5926
.4265 X 5.4401 X
.3092 X .3404 X .3276 X .5326 X
1.0000 12.6960
.7215 .7944 .7650 1.2429
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT 1GC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -SLIGHT. FOCAL -MINIMAL
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCVTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR
THIS 'ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL' .
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG), L F . TESTIS (TEO), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE |SV), URETHRA |UR)
Oo
M
tS4
U1
in
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1S-OCT-91
PAGE: 261
ANIMAL NUMBER: C67706
SEX: MALE
DOSE GROUP: S
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/17/61
STUDY DAY OF DEATH: M B
STUDY WEEK OF DEATH: 22
TERMINAL ODY WEIGHT: 572.0 GRAMS
DATE AND TIME OF NECROPSY: 05/17/91 7:54
PROSECTOR: DEBBIE PIRKEL
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JACK SERFORT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS 1
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR!1 LIVER 1LIj1 LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TEI ACCESS/SEX ORO (SO)
2.1126 21.5633
1.5610 1.7092 1.6711 3.4295
.3110 X 3.7639 X
.2737 X .2913 X .2930 X .5916 X
1.0000 0.1796
.7164 .7131 .7692 1.5713
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING OLD (CO). LF . TESTIS (TEO). LIVER (LI). LUNG |LU|. PROSTATE (PR). SEMINAL VESICLE (SV), URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 262
ANIMAL NUMBER: C67707
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH. 02/12/91
STUDY DAY OF DEATH. 55
STUDY WEEK OF DEATH, t
TERMINAL BODY WEIGHT. 497.5 GRAMS
D-A-T-E---A-N-D--T-I-ME---O-F NEC'ROPSY: 02/12/91 7:34
PROSECTOR: NANCY DIEDRICH
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN S 7A TU S
BRAIN |BR ) LIVER LI) LUNG 1LUI LF. TESTIS (TEO) RT. TESTIS 1TE1 ACCESS/SEX ()RG ISO)
2.1931 30.227t
1.6564 1.7721 1.7930 3.1442
.4410 X 6.0759 X
.3329 X .3562 X .3604 X .6320 X
1.0000 13.7717
.7550 .1071 .1173 1.4332
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC) GJRROrSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -SLIGHT
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP' APPEARANCE. EXCEPT FOR THIS 'ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR), COAGULATING OLD (CG). LF . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|, URETHRA (UR|
(It
(oItt
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 18-OCT-91
PAGE: 263
ANIMAL NUMBER: C67706
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/01
STUDY DAY OF DEATH: 56
STUDY WEEK OF DEATH:
TERMINAL 600V WEIGHT: 505.1 GRAMS
DATE AND TIME OF NECROPSY: 02/13/01 7:42
PROSECTOR: RUTH SCHMITZ
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1] ACCESS/SEX ORG (SO)
2.2070 24.6049
1.5957 1.6074 1.5917 2.6153
.4363 X 4.6923 X
.3155 X .3176 X .3147 X .5171 X
1.0000 11.1894
.7230 .7213 .7212 1.1850
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) ......................... GROSS : -ALL T1SSUES/ORQANS NORMAL
LIVER ILI) .................................... MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR THIS 'ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). L F . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
'Tzczoo
tnI
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 18-OCT-91
PAGE: 284
ANIMAL NUM8ER: C6770B
SEX: MALE
DOSE GROUP: S
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDY DAY OF DEATH: SS
STUDY WEEK OF DEATH: I
TERMINAL BOOY WEIGHT: 364.7 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 9:15
PROSECTOR: NANCY DIEDRICH
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS TE1 ACCESS/SEX ORQ (SO)
2.1310 23.2540
1.3(45 1.6261 1.5577 2.3407
.5143 X 6.3762 X
.3796 X .4459 X .4271 X .6411 X
1.0000 10.9122
.6407 .7631 .7310 1.09(4
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOG KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER (LI)
GROSS: -DIFFUSELY DARK MICRO: -SLIGHT
-ALL LOBES: BROWN -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP' APPEARANCE. EXCEPT FOR THIS 'ENLARGEO' APPEARANCE, THE CELLS ARE OTHERWISE 'NORMAL'.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR). COAGULATING GLD (CO). LF. TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (U R )
n
N CO
Os*
uo0i0v
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 26S
ANIMAL NUMBER. 067710
SEX: MALE
DOSE GROUP: S
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDY DAY OF DEATH: 57
STUDY WEEK OF DEATH: 9
TERMINAL ODY WEIGHT: 453.1 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 7:24
PROSECTOR: KEVIN BILLINGS
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR| LIVER (LI) LUNG (LU) LF. TESTIS TEO) RT. TESTIS Itei ACCESS/SEX (M G (SO)
2.0112 31.2147
1.4613 1.1448 1.6719 3.0033
.4593 X 6.9048 X
.3241 X .4072 X .3705 X .6828 X
1.0000 15.0320
.7055 .8665 .1067 1.4431
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S ** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL C0M4ENT (GC1 .......................................................................... .................................
GROSS. -ALL TISSUES/ORQANS NORMAL
LIVER (LI) ......................................................................................................................
MICRO: -SLIGHT
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE 'PLUMP' APPEARANCE. EXCEPT FOR
THIS 'ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION. BRAIN (8R). COAGULATING GLD (CG). LF . TESTIS (TEO), LUNG |LU), PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 18-OCT-91
PAGE: 266
ANIMAL NUMBER: C67711
SEX: MALE
DOSE GROUP: S
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDY DAY OF DEATH: 57
STUDY WEEK OF DEATH: 9
TERMINAL &00Y WEIGHT: 448.5 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 1:25
PROSECTOR: KEVIN BILLINGS
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1 j ACCESS/SEX ORQ (SO)
1.9929 23.6896
.9224 1.8353 1.8308 2.4993
.4443 X 5.2820 X
.2057 X .4092 X .4082 X .5573 X
1.0000 11.8870
.4628 .9209 .9187 1.2541
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOG KEYWORDS. SEVERITY, DISTRIBUTION
BSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI GROSS : -ALL TISSUES/ORGANS NORMAL
LIVER (LI 1 MICRO: -MINIMAL
PROSTATE (PR I MICRO: -MOOERATE. MULTI-FOCAL
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP' APPEARANCE. EXCEPT FOR THIS 'ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL*. -INFLAMMATION, CHRONic ACTiVE
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CO). L F . TESTIS (TEO). LUNG (LU|. SEMINAL VESICLE (SV|. URETHRA (UR)
n
U1 0 o% u
A'
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1S-0CT-B1
PAGE: 267
ANIMAL NUMBER: C67712
SEX: MALE
DOSE GROUP: S
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL OOY WEIGHT: 513.1 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 7.37
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABBllE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR| LIVER (LI) LUNG (LU) LF. TESTIS (TE011 RT. TESTIS TE1 1 ACCESS/SEX ORO |ISO)
2.2036 33.3605
1.6626 1.1710 1.1626 4.1255
.3775 X 5.7176 X
.2412 X .3217 X .3191 X .7067 X
1.0000 15.1469
.7636 .1522 .4453 1.6720
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PA T H 0 LO G Y O B S E R V A T I 0 N S
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL. FOCAL -SLIGHT
PROSTATE (PR) MICRO: -MODERATE. FOCAL
-INFILTRATES,MONONUCLEAR CELL -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBUlA tED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE `PLUMP- APPEARANCE. EXCEPT FOR THIS `ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL*. -INFLAMMATION. CHRONIC ACTIVE
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG), IF TESTIS (TEO). LUNG (LU|. SEMINAL VESICLE (SV). URETHRA (UR)
D
4oJ>1
0
GO
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US .A .
APPENDIX 0 INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 18-OCT-91
PAGE: 268
ANIMAL NUMBER: C67713
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT. 373 3 GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 8:00
PROSECTOR: JULIE A. LARSEN
RECORDER: NANCY DIEDRICH
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2 2337 25 8610
1.4625 1.6587 1 6381 2.5155
.5914 X 6.9277 X
.3918 X .4443 X .4388 X .6739 X
1.0000 11.5777
.6547 .7426 .7334 1.1262
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEY(S1 (KOI ..................................................................................................................
GROSS: -LARGE PELVIS)ES|
-RIGHT: BOTH COLLECTED
MICRO: -PRESENT
-DILATATION.PELVIC
LIVER (LI) ......................................................................................................................
MICRO: -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
-SLIGHT
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR
THIS 'ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). LF . TESTIS (TEO), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
r>
O N VoI> 4
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U S A .
APPENDIX O INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 269
ANIMAL NUMBER: C67714
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/25/91
STUDY DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL ODY WEIGHT: 415.5 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 9:56
PROSECTOR: JACK SERFORT
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG 1LU) LF. TESTIS (TEO) RT. TESTIS 1TE1) ACCESS/SEX ORG (SO)
2.1574 26.6577
1.4941 1.6633 1.7522 3 2741
.5192 X 6.6972 X
.3596 X .4003 X .4217 X .7660 X
1 0000 13.2634
.6925 .7710 .6122 1.5176
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G KEYWORDS. SEVERITY. DISTRIBUTION
B S ER VA T IONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC] GROSS : -ALL T1SSUES/ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL. FOCAL -SLIGHT
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATEO PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP' APPEARANCE EXCEPT FOR THIS 'ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). L F . TESTIS (TEO), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
r> Q fO
CO
Uft
(l
aCa%
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 270
ANIMAL NUMBER. C6T715
SEX. MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 317.1 GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 1:14
PROSECTOR: DENNIS HOFFMAN
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: OR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS 1
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LIf LUNG (LU) LF. TESTIS (TEO) RT. TESTIS TE1 ACCESS/SEX 0*0 SO)
1.9921 28.0457
1.4195 1 7186 1.8534 2.7785
.5139 X 6.7163 X
.3658 X .4612 X % .4779 X .7165 X
1.0000 13.0699
.7118 .8975 .9300 1.3943
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
*** P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORQANS NORMAL
LIVER ILI) .................................... MICRO: -SLIGHT
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP* APPEARANCE. EXCEPT FOR THIS 'ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR). COAGULATING GLD (CGI. LF . TESTIS (TEOI. LUNG (LU|. PROSTATE (PR ). SEMINAL VESICLE (SV). URETHRA (UR)
(?) o ionn Q
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 271
ANIMAL NUMBER: C67716
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL BOOY WEIGHT: 464.7 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 9:05
PROSECTOR: KEVIN BILLINGS
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER. JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEOI RT. TESTIS iTEll ACCESS/SEX ORO (SO)
2.2060 21.3462
1.5076 1.6194 1.6342 2.1111
.4747 X 4.5935 X
.3431 X .3035 X .3517 X .6049 X
1.0000 9.6764
.7242 .7651 .7406 1.2743
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COM4ENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER lLI) .................................... MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULAt EO PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE `PLUMP* APPEARANCE. EXCEPT FOR THIS `ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR). COAGULATING OLD (CG), LF. TESTIS (TEO). LUNG |LU). PROSTATE (PR), SEMINAL VESICLE (SV|. URETHRA (UR)
Ci
co
Co
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-Ol
PAGE: 272
ANIMAL NUMBER C67717
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH 01/23/91
STUDY DAY OF DEATH: 3S
STUDY WEEK OF DEATH: S
TERMINAL BODY WEIGHT: 361.0 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 7:59
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS 1
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR1 LIVER (LI) LUNG (LU) LF. TESTIS TEO RT. TESTIS (TEI ACCESS/SEX 0RG (S0|
2.0361 25.1591
1.3616 1.6172 1.6543 2.2767
.5642 X B .9695 X
.3792 X .4460 X .4563 X .6312 X
1.0000 12.3526
.6720 .7940 .6122 1.1166
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O Q KEYWORDS. SEVERITY, DISTRIBUTION
B S E RV A T I0 N S * GROSS FREE- TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT 1GC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI I .................................... MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR THIS "ENLARGED" APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING OLD (CG). LF . TESTIS (TEO), LUNG |LU|. PROSTATE (PR|. SEMINAL VESICLE (SV), URETHRA (UR)
fZO
i<n
<71
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
MWI 6329-100 PRINTED: U-OCT-91
PAGE: 273
ANIMAL NUM8ER: C87711
SEX. MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/01
STUOY DAY OF DEATH: 57
STUOY WEEK OF DEATH: 9
TERMINAL OOY WEIGHT. 479.7 GRAMS
DATE AND TIME OF NECROPSY: 02^14/91 1:40
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILAB
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2.1511 34.0653
1 5717 1.4320 1.5203 2.9666
.4414 X 7.1014 X
.3276 X .2965 X .3169 X .6164 X
1.0000 15.6362
.7306 .6657 .7068 1.3791
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** PATHOLG KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IQC) GROSS : -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -SLIGHT. FOCAL -SLIGHT
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE `PLUMP' APPEARANCE. EXCEPT FOR THIS `ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE "NORMAL".
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). L F . TESTIS (TEO), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
'gtczoo
U1
a%
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE. 274
ANIMAL NUMBER: C67719
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDY DAY OF DEATH: 5S
STUOY WEEK OF DEATH: t
TERMINAL BODY WEIGHT: 476.3 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 7:20
PROSECTOR: RUTH SCHMITZ
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR1 LIVER (LI) LUNG ILU) LF. TESTIS (TEO) RT. TESTIS ITE1) ACCESS/SEX ORG (SO)
2176* 30.95(6
1 5670 1 6091 1 6220 2.9267
.4ST0 % 6.499* X
.3290 X .337* X .3405 X .6145 X
1.0000 14.2221
.7199 .7392 .7451 1.3445
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWORDS, SEVERITY, DISTRIBUTION
OSSERVATI 0 N S GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IOC] GROSS : -ALL TISSUES/ORQANS NORMAL
LIVER (LI) MICRO: -MINIMAL. FOCAL -SLIGHT
-INFILTRATES.MONONUCLEAR CELL -HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULTED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE 'PLUMP' APPEARANCE. EXCEPT FOR THIS 'ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL'.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING OLD |CG). L F . TESTIS |TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
oO
w
CO
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE : 275
ANIMAL NUMBER: C67720
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF OEATH. 03/22/81
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 1
TERMINAL BOOY WEIGHT: 8 5 1 1 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 7:12
PROSECTOR: RUTH SCHMITZ
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
1.9403 36.3471
1.5044 1.7913 1.7716 4.4059
.2949 X 5.5230 X
.2216 X .2722 X .2703 X .6695 X
1.0000 11.7327
.7753 .9232 .9167 2.2707
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS *** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
LIVER (LI) .................................................................................... ..................................
MICRO: -SLIGHT
-HYPERTROPHY. HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE 'PLUMP' APPEARANCE. EXCEPT FOR
THIS 'ENLARGED' APPEARANCE, THE CELLS ARE OTHERWISE 'NORMAL*.
MANDI8/CERV LN (MNI ..............................................................................................................
GROSS: -LARGE
-RIGHT: 15 X 10 MM (FOR COMPARISON. LEFT IS 7 X 3 X 2 MM)
(CAP 8)
MICRO: -MOOERATE, MULTI-FOCAL
-HYPERPLASIA, LYMPHORETICULAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING OLD (CG). LF . TESTIS (TEO). LUNG (LU|. PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR)
EC2O0
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: It-OCT-91
PAGE: 276
ANIMAL NUMBER: C67721
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH: 56
STUDY WEEK OF DEATH: 6
TERMINAL BOOY WEIGHT: 451.9 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 7:17
PROSECTOR: DENNIS HOFFMAN
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TElf ACCESS/SEX ORG (SO)
2.0(55 2 t .5414
1.4156 1 1756 1 1333 2.1522
.4615 X 6.3174 X
.3193 X .4150 X .4057 X .6312 X
1.0000 13.6190
.6766 .6994 .1791 1.3676
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S ** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT g Jo : -ALL TISSES/RGANS'NORMAL
LIVER (LI) MICRO: -SLIGHT
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE `PLUMP* APPEARANCE. EXCEPT FOR THIS `ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CO). L F . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
O
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED. 1S-OCT-91
PAGE. 277
ANIMAL NUMBER: C67722
SEX: MALE
OOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDY DAY OF DEATH: S$
STUDY WEEK OF DEATH: I
TERMINAL BODY WEIGHT: 429.1 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 1:57
PROSECTOR: NANCY D1EDRICH
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER ILIf LUNG (LU) LF. TESTIS (TEOI RT. TESTIS (TEI ACCESS/SEX ()RG SO)
1.9111 25.0117
1.5412 1 6711 1.6720 2.9523
.4609 X 5.1210 X
.3516 X .3611 X .3190 X .8669 X
1.0000 12.8217
.7710 .1435 .1440 1.4902
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
O B S E R V A T I O N S * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT |GC) ............................................................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ......................................................................................................................
MICRO: -MINIMAL. FOCAL
-INFILTRATES,MONONUCLEAR CELL
-SLIGHT. FOCAL
-NECROSIS.COAGULATIVE
-MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED
CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE
A MORE HOMOGENEOUS CYTOPLASM ANO THE CELL BORDERS ARE MORE
ROUNDED GIVING THE CELLS A MORE "PLUMP* APPEARANCE. EXCEPT FOR
THIS "ENLARGED* APPEARANCE, THE CELLS ARE OTHERWISE "NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD |CG), LF . TESTIS (TEO1. LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV), URETHRA (UR)
o
OI
Li
Li
fik
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 271
ANIMAL NUMBER. C67723
SEX: MALE
DOSE GROUP: S
SACRIFICE STATUS: SCHEDULED. FIRST POST-RECOV SAC
DATE OF DEATH: 05/17/91
STUDY DAY OF DEATH: 149
STUDY WEEK OF DEATH: 22
TERMINAL BODY WEIGHT: 561.3 GRAMS
DATE AND TIME OF NECROPSY: 05/17/91 9:51
PROSECTOR: DEBBIE PIRKEL
RECORDER: JOE N. KI2ZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: OR. TOM PALMER
WEIGHER: DENNIS HOFFMAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2.1421 16.9011
1.6659 2.0423 1 9492 3.2144
.3111 X 3.0124 X
.2961 X .3639 X .3473 X .5151 X
1.0000 7.1910
.7774 .9531 .9097 1.5321
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT 1GC) GR OS$
LIVER (LI) MICRO
PROSTATE (PR| MICRO
-ALL TISSUES/ORGANS NORMAL -s l i g h t ; FOCAL -s l i g h t ; FOCAL
-INFILTRATES.MONONUCLEAR CELL :INFLAMMATION, CHRONIC ACTIVE
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG|. L F . TESTIS (TEO). LUNG (LU). SEMINAL VESICLE (SV). URETHRA (UR)
o ut
r\>
K
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U.S.A.
APPENDIX O INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE: 279
ANIMAL NUMBER: C67724
SEX: MALE
DOSE GROUP: S
SACRIFICE STATUS: SCHEDULED. SECONO INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH: S6
STUDY WEEK OF DEATH: I
TERMINAL BODY WEIGHT: 472.1 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 7:32
PROSECTOR: JULIE A. LARSEN
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2.1162 31.7972
1.5794 1.7527 1.7111 3.2795
.4493 X 6.7353 X
.3345 X .3713 X .3624 X .6947 X
1.0000 15.0256
.7463 .1212 .9096 1.5497
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOLOG KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) GROSS : -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE "PLUMP" APPEARANCE. EXCEPT FOR THIS "ENLARGED* APPEARANCE. THE CELLS ARE OTHERWISE `NORMAL*.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD |CG), L F . TESTIS |TEO). LUNG |LU), PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA fUR 1
in
e -w~4
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US .A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE. 210
ANIMAL NUMBER: C6772S
SEX: MALE
DOSE GROUP: 5
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUDY DAY OF DEATH: 35
STUDY WEEK OF DEATH. 5
TERMINAL BODY WEIGHT. 346.6 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 9:01
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT 1GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI{ LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TElj ACCESS/SEX ORG (SO)
1.9229 22.9039
1.3277 1.7531 1.7120 2.6365
.5549 X 6.6091 X
.3931 X .5059 X .4939 X .7607 X
1.0000 11.9117
.6905 .9117 .9904 1.3712
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L 0.G V O B S E R V A T I O N S
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER |LI) MICRO: -SLIGHT
-HYPERTROPHY, HEPATOCELLULAR: CHARACTERIZED BY AN ACCENTUATED CENTRILOBULATED PATTERN IN WHICH THE HEPATOCYTES APPEAR TO HAVE A MORE HOMOGENEOUS CYTOPLASM AND THE CELL BORDERS ARE MORE ROUNDED GIVING THE CELLS A MORE 'PLUMP' APPEARANCE. EXCEPT FOR THIS 'ENLARGED' APPEARANCE. THE CELLS ARE OTHERWISE 'NORMAL'.
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN fBR1. COAGULATING OLD (CG). LF. TESTIS |TEO), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV), URETHRA (UR)
0023
tn
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 211
ANIMAL NUMBER: C67726
SEX: MALE
DOSE GROUP: 0
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/01
STUDY DAY OF DEATH: 35
STUDY WEEK OF DEATH: S
TERMINAL BODY WEIGHT: 371.4 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 9:20
PROSECTOR: NANCY DIEDRICH
RECORDER. JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF TESTIS (TEO) RT. TESTIS CTCI 1 ACCESS/SEX ORG (SO)
2 0124 16.4919
1 4624 1.2929 1.3762 2.4971
541 X 4.4424 X
.393 X .3411 X .3705 X .6723 X
1.0000 1.1916
.7267 6425 .6139 1.2409
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC| .........................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ...................................
MICRO: -MINIMAL, FOCAL
PROSTATE IPR) .................................
MICRO -MODERATE. MULTI-FOCAL
GENERAL INFORMATION (XX) .................
GROSS
NECROPSY NOTE:
-INFILTRATES.MONONUCLEAR CELL -INFLAMMATION. CHRONIC ACTIVE ANIMAL DIED'PRIOR T EXSANGUINATION
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING OLD ICO). L F . TESTIS |TEO). LUNG (LU). SEMINAL VESICLE (SV). URETHRA (UR)
oo
0 4/1 Q 4SI
&
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIHAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE: 292
ANIMAL NUMBER: C67727
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/2S/91
STUDY DAY OF DEATH. 37
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 391.9 GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 7:09
PROSECTOR: NANCY DIEDRICH
RECORDER: JACK SERFORT
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X1
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BRI LIVER |LI$ LUNG (LU) LF. TESTIS JTEOI RT. TESTIS TE1 ACCESS/SEX ORG (SO)
2.0154 15.3142
1.6496 1.6110 1.5435 2.9367
.5192 X 3.9379 X
.4242 X .4142 X .3969 X .7294 X
1 0000 7.5996
.9196 .7993 .7659 1 4075
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
OSSERVATI 0NS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
PROSTATE IPR| GROSS: -NODULAR MICRO: -SLIGHT. FOCAL
-DIFFUSELY RED AND FIRM -INFLAMMATION. CHRONIC ACTIVE
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR) . COAGULATING OLD (CGI. LF. TESTIS (TEO). LIVER (LI|. LUNG (LU), SEMINAL VESICLE (SV), URETHRA (UR )
C023
tn
o>
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HW1 6329-100 PRINTED; ll-OCT-91
PAGE: 293
ANIMAL NUMBER. C6772
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH: 56
STUDY WEEK OF DEATH: I
TERMINAL BODY WEIGHT. 436.6 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 7:30
PROSECTOR: DENNIS HOFFMAN
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILAB LE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS|
ORGAN WEIGHT RELATIVE TO 800Y WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TElj ACCESS/SEX ORG (SO)
2.0153 16.4515
1.3673 1 8152 1.6560 3 8721
.4593 X 3.7492 X
.3162 X .3661 X .3774 X .6369 X
1.0000 6 1633
.6664 .6015 8217 1.8221
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) .................................... MICRO: -SLIGHT, FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|. COAGULATING OLD (CGI, L F . TESTIS (TEO |. LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV), URETHRA (UR)
C023
i~n4
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 214
ANIMAL NUMBER: C67T29
SEX: HALE
DOSE GROUP:
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDY DAY OF DEATH: 57
STUDY WEEK OF DEATH: 9
TERMINAL BODY WEIGHT: 460.9 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 1:17
PROSECTOR: RUTH SCHMITZ
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT TESTIS (TEl) ACCESS/SEX ORG (SO)
2.0399 19.9395
1.4969 1 7331 1.6901 3.1071
.4425 X 4.3054 X
.3221 X .3761 X .3646 X .6743 X
1.0000 9.7305
.7292 .9500 .9240 1 5239
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOL 0 G Y OBSERVATIONS
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG), LF . TESTIS (TEO), LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR |
00234
in oo
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 11-0CT-91
PAGE: 2SS
ANIMAL NUMBER: C67730
SEX: MALE
DOSE GROUP: B
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/25/91
STUDY DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 490 1 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 9:33
PROSECTOR: JACK SERFORT
RECORDER: JOE N KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS |TE1) ACCESS/SEX ORG (SO)
2.03(7 16.3501
1.5931 1.6753 1 6759 3.3666
.4160 X 3.3362 X
.3251 X .3411 X .3420 X .6169 X
1.0000 1.0202
.7114 .1217 220 1.6513
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
O B S E R V A T I O N S GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). LF . TESTIS (TEO), LIVER fLI I. LUNG (LU). PROSTATE (PR), SEMINAL VESICLE (SV|, URETHRA (UR)
0234
ui >
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX O INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 216
ANIMAL NUMBER: C67731
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDY DAY OF DEATH: 55
STUDY WEEK OF DEATH: t
TERMINAL ODY WEIGHT: 441 5 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 7:20
PROSECTOR: NANCY DIEDRICH
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LIi LUNG (LU) LF. TESTIS (TEO) RT. TESTIS |TE1| ACCESS/SEX ORG (SO)
2.0231 16.1915
1.6026 1.7209 1.7494 3.5167
.4512 X 3.6101 X
.3573 X .3637 X .3901 X .7641 X
1.0000 6.0005
7919 .6503 .6644 1.7377
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y O B S E R V A T I O N S
KEYWORDS. SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI .................................... GROSS: -ALL TISSUES/ORGANS NORMAL
URETHRA (UR) ............................................ MICRO: -SECTION EXAMINED. TISSUE NOT PRESENT
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR |, COAGULATING GLD (CG). LF . TESTIS (TEO). LIVER (LI). LUNG (LU|, PROSTATE (PR). SEMINAL VESICLE (SV|
ro
HAZLETON LABORATORIES AMERICA. INC MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: U-OCT-91
PAGE: 217
ANIMAL NUMBER: C67732
SEX: MALE
DOSE GROUP: 8
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF OEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL ODY WEIGHT: 532.2 GRAMS
DATE ANO TIME OF NECROPSY: 03/26/91 7:52
PROSECTOR: DEBBIE PIRKEL
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZ1EE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BRI LIVER jLI | LUNG (LU) LF. TESTIS ITEOI RT. TESTIS TE1 ACCESS/SEX ORG (SO)
2.2336 15.8333
1.5756 2 0543 1.9969 2 2449
.4197 X 2.9375 X
.2961 X .3960 X .3733 X .4219 X
1.0000 6.9991
.7054 .9197 .9995 1 .ooso
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L OG Y O B S E R V A T I O N S
KEYWORDS, SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT 1GC1 GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CGI. LF . TESTIS (TEO|, LIVER (LI ). LUNG (LU|, PROSTATE (PR|, SEMINAL VESICLE (SV|. URETHRA (UR)
002341
V09
HAZLETON LABORATORIES AMERICA, INC. MAOISON, WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 211
ANIMAL NUMBER: C67733
SEX: MALE
DOSE GROUP:
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUDY DAY OF DEATH: 3S
STUDY WEEK OF DEATH: 5
TERMINAL BODY WEIGHT: 314.1 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 7:33
PROSECTOR: NANCY DIEDRICH
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
0RGAN S TA TU S
BRAIN (BR) LIVER (LI) LUNG |LU) LF. TESTIS (TEO) RT. TESTIS TE1 ACCESS/SEX ORQ (SO)
1 9318 16.7275
1.5339 1.7851 1 7714 1 8099
.4769 X 4.3550 X
.3993 X .4595 X .4812 X .4191 X
1.0000 9 1327
.1375 .9637 .9671 .9790
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * * PATHOL 0 G V O B S E R V A T IONS * *
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI GR OSS: -ALL TISSUES/ORGANS NORMAL
LIVER ILI) MICRO: -SLIGHT, FOCAL -SLIGHT. DIFFUSE
-NECROSIS,COAGULATIVE -FATTY CHANGE
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). L F . TESTIS (TEO). LUNG (LU|. PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
r>
U1
1 0 CrOo
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 219
ANIMAL NUMBER. CB7T34
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDY DAY OF DEATH: SS
STUDY WEEK OF DEATH: I
TERMINAL BODY WEIGHT: 416.S GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 * 3 5
PROSECTOR. KEVIN BILLINGS
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1$ ACCESS/SEX ORG (SO)
2.0770 15.5695
1.4530 1.5371 1.523* 3.0402
.49*7 X 3.73*2 X
.3419 X .3691 X .3659 X .7299 X
1.0000 7 4961
.6996 .7401 .7337 1.4637
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y KEYWORDS. SEVERITY, DISTRIBUTION
O B S E R V A T I O N S * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING OLD (CG). LF . TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (U&)
gl-CZGO
i0n0
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 290
ANIMAL NUMBER: C67735
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF OEATH: 01/24/91
STUDY DAY OF DEATH. 3
STUDY WEEK OF DEATH:
TERMINAL BODY WEIGHT: 363.7 GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 7:53
PROSECTOR: DENNIS HOFFMAN
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR;1 LIVER (LI 1 LUNG (LU) LF TESTIS (TEO) RT TESTIS 1TEI 1 ACCESS/SEX ORO (SO)
1.9243 17.0561
1.5462 1.5107 1 4701 2.2190
.5015 X 4.4453 X
.4035 X .3937 X .3831 X .5783 X
1.0000 8.8639
.8046 .7851 .7640 1.1531
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
*** P A T H O L O G Y KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER |LI1 ................................... MICRO: -MINIMAL. FOCAL
-INFILTRATES,MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|, COAGULATING GLD |CG|, LF . TESTIS (TEO). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
u0i0
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1S-OCT-91
PAGE: 291
ANIMAL NUMBER. C6TT36
SEX: MALE
DOSE GROUP: 8
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL BOOY WEIGHT. 516 5 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 9:27
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER. JOE N. KIZZ1EE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TElj ACCESS/SEX ORQ 1SO)
2.1141 15.9731
1.4705 1 7649 1.7359 3.2314
.4093 X 3.0733 X
.2147 X .3417 X .3361 X .6270 X
1.0000 7.5085
.6956 .1341 .9211 1.5318
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L OG KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ................................... MICRO: -SLIGHT, FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION. BRAIN (BR|, COAGULATING OLD |CG|. LF . TESTIS (TEO). LUNG |LU|. PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR)
O
O fO
i0n0
CO in
cn
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-OCT-B1
PAGE: 292
ANIMAL NUMBER: C67737
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDY DAY OF DEATH: SS
STUDY WEEK OF DEATH: I
TERMINAL &ODY WEIGHT: 460 5 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 1:47
PROSECTOR: RUTH SCHMITZ
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS ITE11 ACCESS/SEX ORG |SOI
2.1644 15.9016
1.6510 1.5674 1.5173 3.1673
.4700 X 3.4547 X
.3595 X .3404 X .3295 X .6921 X
1.0000 7.3502
.7628 .7242 .7010 1.4726
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y KEYWORDS. SEVERITY, DISTRIBUTION
O B S E R V A T I O N S * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG), LF . TESTIS (TEO), LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
rr O
001
a%
?\3
C4
HA2LETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: It-OCT-91
PAGE: 293
ANIMAL NUMBER: C6773S
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/25/91
STUDY DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 523.1 GRAMS
DATE ANO TIME OF NECROPSY. 03/25/91 9:42
PROSECTOR: JACK SERFORT
RECORDER: JOE N. KIZ21EE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOOIST: DR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORQAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR) LIVER (LI) LUNG (LU) LF TESTIS ITEO) RT. TESTIS (TEI ACCESS/SEX 'ORG (SO)
2.1391 17.0909
1.6276 1.9505 1.7333 3.2127
.4091 X 3.2672 X
.3112 X .3729 X .3314 X .8142 X
1.0000 7.9171
.7606 .9115 .1100 1.5014
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O I O G Y O B S E R V A T I O NS
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) . . GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL. FOCAL
-INFILTRATES,MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR) . COAGULATING1 GLD (CG). LF. TESTIS (TEO).. LUNG (LU). PROSTATE (PR) . SEMINAL VESICLE (SV). URETHRA (U R )
r> O
uot
HA2LETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-0CT-91
PAGE: 294
ANIMAL NUMBER: C67739
SEX: MALE
DOSE GROUP: 8
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDY DAY OF DEATH: 57
STUDY WEEK OF DEATH: 9
TERMINAL OOV WEIGHT: 467.4 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 7:13
PROSECTOR: KEVIN BILLINGS
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER {LI| LUNG (LU) LF. TESTIS ITEOI RT. TESTIS Itei ACCESS/SEX (M G (SO)
2.1329 16.0550
1.4065 1.4691 1.4416 2.0103
.4563 X 3.4350 X
.3009 X .3145 X .3064 X .4301 X
1.0000 7.5273
.6594 .6191 .6759 .9425
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S ** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR), COAGULATING OLD (CG). LF . TESTIS (TEO|, LIVER (LI). LUNG (LU|. PROSTATE fPR). SEMINAL VESICLE (SV). URETHRA (UR|
0 N
Co
01
Csl
U 8
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX 0 INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: H-OCT-91
PAGE: 295
ANIMAL NUMBER: C67740
SEX: MALE
DOSE GROUP- B
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 466.7 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 9:29
PROSECTOR: RUTH SCHMITZ
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TElj ACCESS/SEX ORG (SO)
2.1000 15.2555
1 3691 1.6609 1.6399 3.0965
.4500 X 3.2611 X
.2934 X .3559 X .3514 X .6635 X
1.0000 7.2645
.6520 .7909 .7109 1.4745
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
*** P A T H O L O G Y KEYWORDS, SEVERITY, DISTRIBUTION
O B S E R V A T I O N S ** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL C0M4ENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING OLD (CO). LF. TESTIS (TEO). LIVER (LI), LUNG (LU|, PROSTATE (PR 1. SEMINAL VESICLE (SV|. URETHRA (UR|
0023
ICnD
\o
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 296
ANIMAL NUMBER: C67741
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUDY DAY OF DEATH: 3S
STUDY WEEK OF DEATH: 5
TERMINAL ODY WEIGHT: 393.5 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 7:30
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL SEVAN
POST-FIX WEIGHER. NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TEI ACCESS/SEX (>RG (SO)
1.9491 15.6120
1.5300 1.6557 1.7416 2.9005
.4955 X 3.9675 X
.3661 X .4206 X .4426 X .7117 X
1.0000 8.0070
.7147 492 .1932 1.4363
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** * PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS *** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCJ ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN fB R ). COAGULATING OLD (CGI, LF . TESTIS (TEO), LIVER (LI), LUNG (LU|. PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
00235
U1 %oo
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 297
ANIMAL NUMBER: C67742
SEX. MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/91
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 316.0 GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 7:05
PROSECTOR: DENNIS HOFFMAN
RECOROER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: OR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BRI LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TEI) ACCESS/SEX iORG (SO)
1.9377 16.1264
1.2800 1 6971 1.6902 2.8718
.5020 X 4.1778 X
.33IB X .4397 X .4379 X .7440 X
1.0000 8.3224
.6608 .8758 .8723 1.4821
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * * P A T H 0 L 0. G V 0 8 S E R V A T I 0 N S
KEVWOROS. SEVERITY, DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
KIDNEY(S) (KD) GROSS: -LARGE PELVSES) MICRO: -PRESENT
RIGHT: BOTH COLLECTED -DILATATION.PELVIC
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (SR), COAGULATING GLO (CG|. L F . TESTIS (TEO). LIVER (LI). LUNG |LU). PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
ISC200
oot Os
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 296
ANIMAL NUMBER: C67743
SEX: MALE
DOSE GROUP: B
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH: 56
STUDY WEEK OF DEATH: I
TERMINAL BODY WEIGHT: 436.9 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 7:17
PROSECTOR: JULIE A. LARSEN
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOT WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN 1BRI} LIVER (LI] LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2.2613 17.6532
1.6951 1.8251 1.5219 2.2869
.5152 X 4.0221 X
.3162 X .3703 X .3483 X .5211 X
1.0000 7.8067
.7496 .7187 .6761 1.0113
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PA T H 0 L O G V O B S E R V A T I 0 N S *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT |GC| GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -SLIGHT. MULTI-FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|, COAGULATING OLD |CG), LF TESTIS (TE0|, LUNG (LU). PROSTATE (PR), SEMINAL VESICLE (SV|. URETHRA (UR|
ft
N co
if\no>
Cfl
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 299
ANIMAL NUMBER: C67744
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH. 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 503.7 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 1:51
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL BEVAN
POST-FIX WEIQHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER. JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORQ (SO)
2 2132 16.5120
1.5761 1.6972 1.7311 4.6774
.4394 X 3.2920 X
.3130 X .3369 X .3451 X .9216 X
1.0000 7.4923
.7125 .7669 .7153 2 1134
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TfXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCJ ......................... GROSS. -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR), COAGULATING OLD (CG|, LF . TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE (PR), SEMINAL VESICLE (SV|. URETHRA (UR)
SC200
uio
(a )
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 19-OCT-91
PAGE. 300
ANIMAL NUMBER: C6T745
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUDY DAY OF DEATH: 35
STUDY WEEK OF DEATH: 5
TERMINAL BODY WEIGHT: 396.0 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 9:07
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BRI1 LIVER (LI|1 LUNG (LU) LF. TESTIS (TEO) RT. TESTIS iTE 1) ACCESS/SEX ORG (SO)
2.0090 15 1599
1.5159 1.7793 1.7379 2.4131
.5073 X 3.9292 X
.3929 X .4491 X .4399 X .6094 X
1.0000 7.5459
.7546 .9952 .9650 1.2011
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATI 0 NS ** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR), COAGULATING OLD (CGI. LF . TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (Ulh
r>
in
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE. 301
ANIMAL NUMBER: C67746
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS. SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/25/91
STUDY DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL 00Y WEIGHT: 474.3 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 6:27
PROSECTOR: JACK SERFORT
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: STEVE VAN ADCST INC
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO 800V WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR!I LIVER 1LI! LUNG (LU| LF TESTIS ITEO) RT. TESTIS 1TEI ACCESS/SEX ORG (SO)
2 1136 14.3227
1.7241 1.6021 1.5766 3.4211
.4456 X 3.0196 X
.3637 X .3376 X .3324 X .7229 X
1.0000 6.7764
.6160 .7560 .7460 1.6223
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L 00 KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT fGCI GROSS -ALL TISSUES/ORGANS NORMAL
LIVER (LI) . . . . MICRO: -MINIMAL FCL..........
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG|, LF. TESTIS (TEOI. LUNG (LU|. PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
CO
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 302
ANIMAL NUMBER: C67747
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 536.4 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 1:19
PROSECTOR: STEVE VAN ADESTINE
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR| LIVER (LI) LUNG (LU) LF. TESTIS ITEOI RT. TESTIS 1TE 11 ACCESS/SEX ORO (SO)
2.1360 20.6866
1.4971 1.6121 1.5406 3.5381
.3912 X 3.6943 X
.2792 X 3005 X .2672 X .6592 X
1.0000 9.7794
.7012 .7547 .7213 1.6555
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * * P A T H O L 00 V O B S E R V A T I O N S *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT JGCI
GROSS: -ALL TISSUES/ORGANS NORMAL
GENERAL INFORMATION (XX) ...................................................................................................
GROSS:
NECROPSY NOTE: ANIMAL DIED PRIOR TO EXSANGUINATION; BLOOD SAMPLE COLLECTED
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (C Q 1. LF . TESTIS (TEO|. LIVER (LI 1. LUNG |LU|. PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
scsoo
iiOOln
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-Ol
PAGE: 303
ANIMAL NUMBER: C6774S
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUOY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 503 4 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 9:00
PROSECTOR: KEVIN BILLINGS
RECORDER: JOE N KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2 1320 15.9957
1.6252 1 6997 1 7396 3.7221
.4235 X 3.1775 X
.3221 X .3376 X .3456 X .7394 X
1.0000 7 5027
.7623 .7972 .1159 1.7456
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * PATHOLOGY KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS : -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CG). L F . TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
IDO
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 19-OCT-91
PAGE: 304
ANIMAL NUMBER: C67749
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS. SCHEOULEO, TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL OOY WEIGHT: 495.6 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 9:12
PROSECTOR: KEVIN BILLINGS
RECORDER. JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR| LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1I ACCESS/SEX ORG (SO)
2.1303 16.2509
1 5990 1 6322 1.5716 2.9974
.4299 X 3.2790 X
.3224 X .3293 X .3171 X .5926 X
1.0000 7.6294
.7501 .7662 .7377 1.3554
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
*** PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS ** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (OC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER ILI) MICRO: -MINIMAL. MULtl-FOCAL
PROSTATE (PR) MICRO: -SLIGHT; FOCAL
-INFILTRATES.MONONUCLEAR CELL -INFLAMMATION. CHRONIC ACTIVE
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (SR). COAGULATING GLD (CG). L F . TESTIS (TEO). LUNG (LU). SEMINAL VESICLE |SV|. URETHRA (UR)
00236,5
in %00o
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED. 18-OCT-91
PAGE : 305
ANIMAL NUMBER: C87750
SEX: MALE
DOSE GROUP:
SACRIFICE STATUS: SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH: 56
STUDY WEEK OF DEATH: I
TERMINAL BOOY WEIGHT: 448 0 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 7:15
PROSECTOR: RUTH SCHMITZ
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER; JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER ILI) LUNG (LU) LF TESTIS (TEO) RT. TESTIS 1TE11 ACCESS/SEX ORG (SO)
1.9796 15.5428
1.3520 1.4122 13.4660 2.6175
.4419 X 3.4694 X
.3011 X .3152 X 3.0058 X .5143 X
1.0000 7.8515
.6830 .7134 6.8024 1.3222
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN EXCLUDE WEIGHT TAKEN
ORGAN NAME
** PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING OLD (CG). LF. TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 18-OCT-91
PAGE : 306
ANIMAL NUMBER: C67TS1
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 6
TERMINAL BOOY WEIGHT. 367.0 GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 6:15
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL BEVAN
POST-FIX WEIGHER; NOT AVAILABLE
PATHOLOGIST: DR. TOH PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR| LIVER (LI $ LUNG (LU) LF. TESTIS (TEO) RT TESTIS (TE1) ACCESS/SEX ORG (SO)
2.0547 14.2522
1 5778 1.4513 1.4922 2.4998
.5309 X 3.6827 X
.4077 X .3750 X .3856 X .6459 X
1.0000 6.9364
.7679 .7063 .7262 1.2168
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR). COAGULATING OLD (CG). LF TESTIS (TEO), LIVER (LI). LUNG |LU), PROSTATE (PR|, SEMINAL VESICLE (SV). URETHRA (UR)
r>
O
0 CO
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOQV DATA
HUI 6329-100 PRINTED: 18-OCT-91
PAGE: 307
ANIMAL NUMBER: C87752
SEX: MALE
DOSE GROUP. 6
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDY DAY OF DEATH: 57
STUDY WEEK OF DEATH: 9
TERMINAL BOOY WEIGHT: 490.0 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 7:IS
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST. DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) IF. TESTIS (TEO 1 RT TESTIS It e i I ACCESS/SEX (3RG 1|SO|
2.1100 18.8719
1.5144 1.7674 1.7356 2.8611
.4449 X 3.1514 X
.3233 X .3607 X .3542 X .5431 X
1.0000 6.6566
.7266 .6107 .7961 1.2207
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PA T H O L G Y KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVAT I0 N S * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCJ GROS;>: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR|, COAGULATING OLD (CG|, L F . TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR|
Oo
fO
Co
Oo)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: U-OCT-91
PAGE. 301
ANIMAL NUMBER: C677S3
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDY DAY OF DEATH. 57
STUDY WEEK OF DEATH:
TERMINAL BODY WEIGHT: 475 7 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 7:47
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS 1
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO ) RT. TESTIS (TCI ) ACCESS/SEX ORG (SO)
1.9936 21.3720
1.6053 1.6930 1.7542 3.1131
ORGAN NAME
. . * PA T H 0 L 0 G Y KEYWORDS. SEVERITY. DISTRIBUTION
.4191 X 4.4927 X
.3375 X .3559 X .3611 X .6691 X
1.0000 10.7203
052 .1492 799 1.5967
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
OBSERVATI 0 N S ** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT |GC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR}. COAGULATING GLD |CG), L F . TESTIS (TEO). LIVER (LI). LUNG (LU|. PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
00236,
CM
Oro
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HUI 6329-100 PRINTED: li-OCT-91
PAGE: 309
ANIMAL NUMBER: C67754
SEX: MALE
DOSE GROUP: 8
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/25/91
STUDY DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL ODY WEIGHT: $46.3 GRAMS
DATE AND TIME OF NECROPSY. 03/25/91 7:56
PROSECTOR: JACK SERFORT
RECORDER: JOE N. K1ZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS 1
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG |LU) LF TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2 1791 18.1130
1.7299 1.7984 1.8088 4.4033
.3990 X 3.3284 X
.3187 X .3292 X .3311 X .8080 X
1 0000 8.3416
.7938 .8250 .8297 2.0200
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC1 .......................................................................... .....................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ............................................................................................................
MICRO: -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|, COAGULATING GLD (CO). LF TESTIS (TEO). LUNG (LU|, PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
fsCSGO
auo>t
5
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 19-OCT-91
PAGE: 310
ANIMAL NUM8ER: C6775S
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 473 7 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 9:27
PROSECTOR: KEVIN BILLINGS
RECORDER: JOE N. K1ZZ1EE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL BEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN IBRI LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS TE11 ACCESS/SEX 0RG (SO)
2 1551 13.9650
1.7195 1.722* 1.73*5 2.2*31
,,
.4550 X 2.94*1 X
.3830 X .3637 X .3670 X .4*20 X
1.0000 6.4*00
.7979 .7994 067 1.0594
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
BSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) GROSS : -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO: -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). LF . TESTIS (TEO|. LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR|
C023
ooi
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 1I-OCT-B1
PAGE: 311
ANIMAL NUMBER: C677S6
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/26/91
STUDY DAY OF DEATH: 97
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 490.0 GRAMS
DATE AND TIME OF NECROPSY: 03/26/91 7:10
PROSECTOR: STEVE VAN ADESTINE
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JOE N. KIZZIEE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR)
LIVER |L1)
LUNG (LU )
LF. TESTIS ITEOI
RT. TESTIS ACCESS/SEX
0>(RTGEI (SO)
2.0271 16.32*5
1.5033 1.5453 1.5535 3.0065
.4137 X 3.3323 X
.3066 X .3154 X .3170 X .6136 X
1.0000 1 0551
.7416 .7623 .7684 1.4132
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * PATHOL O G Y OBSERVATIONS * *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC) ........................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ...................................................................................
MICRO: -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|. COAGULATING GLD (CG). LF . TESTIS (TE0|, LUNG (LU|, PROSTATE (PR|. SEMINAL VESICLE (SV). URETHRA (UR)
0&CZOO
ooi ni
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 312
ANIMAL NUMBER: C67757
SEX: MALE
OOSC GROUP: S
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH: 37
STUOY WEEK OF DEATH: 6
TERMINAL BODY WEIGHT: 403.1 GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 9:23
PROSECTOR: DENNIS HOFFMAN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR1 LIVER 1LIi LUNG (LU) LF. TESTIS (TEO 1 RT. TESTIS (TE1 1 ACCESS/SEX ORG (SO)
2.1907 16.2709
1.5371 1.6117 1.6309 2.0109
ORGAN NAME
* * PA T H 0 L 0 G Y KEYWORDS. SEVERITY, DISTRIBUTION
.5410 X 4.0364 X
.3915 X .4016 X .4046 X .7221 X
1.0000 7.4613
.7052 .7423 .7479 1.3349
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
OSSERVATI 0 NS
`
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COFMENT (GC1 GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN 1BRI. COAGULATING OLD (CG). LF. TESTIS (TEO), LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
00237
Os oOs
HA2LETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 313
ANIMAL NUMBER: C67756
SEX: MALE
DOSE GROUP 6
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/14/91
STUDY DAY OF DEATH: S7
STUOV WEEK OF DEATH: 9
TERMINAL BODY WEIGHT: 44S.6 GRAMS
DATE AND TIME OF NECROPSY: 02/14/91 9:01
PROSECTOR: RUTH SCHMITZ
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: VAL QUINN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEOI RT. TESTIS (TEl ACCESS/SEX (IRQ {SO)
2.1977 14.6527
1 5914 1.5123 1.6445 2.9296
.4932 X 3.2663 X
.3571 X .3551 X .3691 X .6575 X
1.0000 6.6673
.7241 .7200 .7413 1.3330
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
PATHOLOGY KEYWORDS, SEVERITY, DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL C0*NT (QC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) ................................... MICRO: -MINIMAL. MULTI-FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING OLD (CO). L F . TESTIS |TEO), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR|
oo-i4
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 18-OCT-91
PAGE: 314
ANIMAL NUMBER: C07750
SEX: MALE
DOSE GROUP: 0
SACRIFICE STATUS. SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/24/01
STUDY DAY OF DEATH: 36
STUDY WEEK OF DEATH: 8
TERMINAL BODY WEIGHT. 402.3 GRAMS
DATE AND TIME OF NECROPSY: 01/24/91 7.06
PROSECTOR: KEVIN BILLINGS
RECORDER: VAL QUINN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: DEBBIE PIRKEL
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG 1LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2.0770 15.2773
1.4004 1.5(16 1 4905 1.9775
.5165 X 3.7975 X
.34(1 X .3949 X .3705 X .4915 X
1.0000 7.3523
.6739 .7645 .7173 .0517
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWORDS. SEVERITY, DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC1 ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR), COAGULATING OLD (CGJ, LF . TESTIS (TEO), LIVER (LI|, LUNG (LU|, PROSTATE (PR). SEMINAL VESICLE |SV). URETHRA (U*)
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HW1 6329-100 PRINTED: 19-OCT-91
PAGE: 315
ANIMAL NUMBER: C67760
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED. TERMINAL SACRIFICE
DATE OF DEATH: 03/22/91
STUDY DAY OF DEATH: 93
STUDY WEEK OF DEATH: 14
TERMINAL BOOY WEIGHT: 496.1 GRAMS
DATE AND TIME OF NECROPSY: 03/22/91 1:49
PROSECTOR: RUTH SCHMITZ
RECORDER: JOE N. KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS 1
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER |LI| LUNG (LU) IF. TESTIS (TEO) RT. TESTIS (TE1 j ACCESS/SEX ORG (SO)
2.1114 IS. 6452
1.6650 1.5640 1.5650 2.7657
.4256 X 3.1S36 X
.3356 X .3153 X .3155 X .5575 X
1.0000 7.4099
.7116 .7407 .7412 1.3099
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING OLD (CG|, L F . TESTIS (TEO), LIVER (LI), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV|. URETHRA (UR)
r>
O
N CO
Ooo*
HAZLETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 316
ANIMAL NUMBER: C67761
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUOY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 8
TERMINAL BODY WEIGHT: 391.9 GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 7:45
PROSECTOR: JULIE A. LARSEN
RECORDER: JACK SERFORT
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (B R 11 LIVER fLIj LUNG (LU) LF. TESTIS ITEO1 RT TESTIS (TEI ACCESS/SEX ORG (SO)
2 0687 IS.4581
1 4140 1 5977 1 5925 2.8961
.5279 X 3.9439 X
.3801 X .4077 X .4064 X .6810 X
1.0000 7.4714
.6835 .7723 .7698 1.3033
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y KEYWOROS, SEVERITY, DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING OLD (CO). L F . TESTIS (TED). LIVER (LI|, LUNG (LU), PROSTATE (PR), SEMINAL VESICLE (SV|. URETHRA (UR|
d
ro
AMo
Co
HAZLETON LABORATORIES AMERICA, INC. MADISON. WISCONSIN U.S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 18-OCT-91
PAGE: 317
ANIMAL NUMBER: C67762
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/23/91
STUDY DAY OF DEATH: 35
STUDY WEEK OF DEATH: 5
TERMINAL BODY WEIGHT: 366.8 GRAMS
DATE AND TIME OF NECROPSY: 01/23/91 1:21
PROSECTOR: NANCY OIEORICH
RECORDER: 3ILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: GAIL M. NOVAK
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN LIVER
((LBIRj|1
LUNG (LU)
LF. TESTIS (TEO)
RT. TESTIS (TE11
ACCESS/SEX ORG (SO)
2.0710 16.7S85
1.5921 1.6769 1.6002 2.6627
.5327 X 4.3103 X
.4097 X .4313 X .4116 X .6649 X
1 0000 8.0920
.7691 .8097 .7727 1.2857
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* PATHOL O G V OBSERVA T I O N S
KEYWORDS, SEVERITY. DISTRIBUTION
GROSS FREE- TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) GROSS : -ALL TISSUE S/ORQANS NORMAL
LIVER (LI) MICRO: -MINIMAL, FOCAL
-INFILTRATES .MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLO (CG|. LF . TESTIS (TEO). LUNG (LU1, PROSTATE (PR|, SEMINAL VESICLE (SV). URETHRA (UR)
(Ti
a
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 19-0CT-B1
PAGE: 319
ANIMAL NUMBER: C67763
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH: $6
STUDY WEEK OF DEATH: I
TERMINAL BODY WEIGHT: 479.9 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 1:31
PROSECTOR: RUTH SCHMITZ
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN |BR| LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS (TE1) ACCESS/SEX ORG (SO)
2.0315 11.9615
1.6339 1.7633 1.7636 2.4933
.4249 X 3.9303 X
.3404 X .3674 X .3675 X .5195 X
1.0000 9.2526
.601S .9650 .9651 1.2231
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G Y KEYWORDS, SEVERITY. DISTRIBUTION
OBSERVATIONS GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
MANDIB/CERV LN I M N 1 ............................................................................ ....................................
GROSS: -LARGE
-RIGHT: UP TO 19 X 9 X 5 MM (FOR COMPARISON LEFT IS 6 X 3 X 2 MM|
(CAP 6)
MICRO: -MODERATE. MULTI-FOCAL
-HYPERPLASIA. LYMPHORETICULAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN |BR), COAGULATING OLD (CG). LF . TESTIS (TEO). LIVER fLI 1. LUNG (LU). PROSTATE (PR), SEMINAL VESICLE (SV|. URETHRA (UR)
.C200
*O--l*
IM
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENOIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTCO. 1I-OCT-9J
PAGE: 319
ANIMAL NUMBER: C6TT64
SEX: MALE
DOSE GROUP: B
SACRIFICE STATUS: SCHEDULED, FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH: 37
STUOY WEEK OF DEATH: 6
TERMINAL OOY WEIGHT: 392.0 GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 9:17
PROSECTOR: NANCY DIEDRICH
RECORDER: JILL BEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS 1t e i | ACCESS/SEX ()RQ (SO)
1.0914 18.5557
1.7763 1.6393 1.6390 2.4532
ORGAN NAME
** PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
.5010 X 4.2234 X
.4531 X .4162 X 4111 X 6251 X
1 0000 6.3136
.6920 .8232 .8230 1.2319
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
OBSERVATI 0NS **
*
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI .................................... GROSS: -ALL TISSUES/ORGANS NORMAL
URETHRA (UR) ............................................ MICRO: -SECTION EXAMINED; TISSUE NOT PRESENT
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG). L F . TESTIS (TEO). LIVER (LI). LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV)
8iuczOD
9
M (a>
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 19-OCT-91
PAGE : 320
ANIMAL NUMBER: C6776S
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS. SCHEDULED. SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/13/91
STUDY DAY OF DEATH: 56
STUDY WEEK OF DEATH: (
TERMINAL BODY WEIGHT: 439.3 GRAMS
DATE AND TIME OF NECROPSY: 02/13/91 9:45
PROSECTOR: DENNIS HOFFMAN
RECORDER: KEVIN BILLINGS
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: JILL SEVAN
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BOOY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT TESTIS (TE1) ACCESS/SEX ORG (SO)
2.1S96 16.4709
1.7457 1.5519 1 5495 2.9217
.4916 X 3.7493 X
.3974 X .3532 X .3525 X .6651 X
1.0000 7.6269
.9093 .7196 .7170 1.3529
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S ** GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINOINGS
GENERAL COMMENT IOC I ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|, COAGULATING OLD (CG|. L F . TESTIS (TEO). LIVER (LI|, LUNG (LU|. PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
o*
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: H-OCT-91
PAGE: 321
ANIMAL NUMBER: C67766
SEX: MALE
DOSE GROUP: 8
SACRIFICE STATUS. SCHEDULED, SECOND INTERIM SACRIFICE
DATE OF DEATH: 02/12/91
STUDY DAY OF DEATH: SS
STUDY WEEK OF DEATH: I
TERMINAL ODY WEIGHT: 392 4 GRAMS
DATE AND TIME OF NECROPSY: 02/12/91 7:20
PROSECTOR: KEVIN BILLINGS
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS }TE1) ACCESS/SEX ORG (SOI
1.9591 12.4009
1 4526 1 5927 1 5625 2.1564
.4994 X 3.1603 X
.3702 X .4059 X .3912 X .7279 X
1.0000 6.3276
.7412 .1127 .7973 1.4575
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* P A T H O L O G KEYWORDS. SEVERITY. DISTRIBUTION
OBSERVATIONS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GC) GROSS: -ALL TISSUES/ORQANS NORMAL
LIVER (LI) . . . . MICRO: -MINIMAL. FOCAL..........
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR). COAGULATING GLD (CG|, LF . TESTIS (TEO), LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR)
r>
N Co 00
HAZLETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN U S.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: 16-OCT-91
PAGE : 322
ANIMAL NUMBER: C67767
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED, TERMINAL SACRIFICE
DATE OF DEATH: 03/25/91
STUDY DAY OF DEATH: 96
STUDY WEEK OF DEATH: 14
TERMINAL BODY WEIGHT: 503.9 GRAMS
DATE AND TIME OF NECROPSY: 03/25/91 7:45
PROSECTOR: JULIE A. LARSEN
RECORDER: JOE N KIZZIEE
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: OR. TOM PALMER
WEIGHER: STEVE VAN ADESTINE
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR) LIVER (LI) LUNG ILU) LF. TESTIS (TEO) RT. TESTIS 1TE11 ACCESS/SEX ORG (SO)
2.2220 16.1137
1.5364 1.6959 1.7503 3.0260
.4410 X 3.2117 X
.3049 X .3366 X .3474 X .8005 X
1.0000 7.2134
.6914 .7632 .7677 1.3611
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * PATHOLOGY KEYWORDS. SEVERITY. DISTRIBUTION
OSSERVATI 0NS * GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT (GCl GROSS : -ALL TISSUES/ORGANS NORMAL
LIVER (LI) MICRO : -SLIGHT. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR|. COAGULATING OLD ICQ). LF. TESTIS (TEO), LUNG (LU|, PROSTATE (PR 1. SEMINAL VESICLE (SV). URETHRA (UR|
HAZLETON LABORATORIES AMERICA. INC. MADISON, WISCONSIN U S A .
APPENDIX D INDIVIDUAL ANIHAL PATHOLOGY DATA
HWI 6329-100 PRINTED: H-OCT-91
PAGE : 323
ANIMAL NUMBER: C6776
SEX. MALE
DOSE OROUP: 6
SACRIFICE STATUS. SCHEDULED, SECOND INTERIM SACRIFICE
DATE Of DEATH: 02/12/91
STUOY DAY OF DEATH: 55
STUDY WEEK OF DEATH:
TERMINAL OOY WEIGHT: 437.3 GRAMS
DATE AND TIME OF NECROPSY 02^12/91 1:21
PROSECTOR: NANCY DIEDRICH
RECORDER: DENNIS HOFFMAN
POST-FIX WEIGHER: NOT AVAILAB
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN (BR|1
LIVER LUNG
(L I (LU)
!1
LF. TESTIS (TEO)
RT. TESTIS (TEl)
ACCESS/SEX ORG (SO)
2.0700 17.7753
1.7744 1.1269 1.7633 2.7252
.4734 X 4.064 X
.4051 X .4171 X .4032 X .6232 X
1.0000 1.5171
.1572 .26 511 1.3165
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
* * PA THO L0G V OBSERVATIONS *
KEYWORDS. SEVERITY. DISTRIBUTION
GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT JGC) ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER (LI) .................................... MICRO: -MINIMAL. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (BR), COAGULATING GLD (CGI. L F . TESTIS (TEOJ, LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV), URETHRA (UR)
D
N o% CO t--*
HA2LETON LABORATORIES AMERICA, INC. MADISON, WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: ll-OCT-91
PAGE: 324
ANIMAL NUMBER: 067769
SEX: MALE
DOSE GROUP: 6
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH. 01/25/91
STUOY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 6
TERMINAL BOOY WEIGHT. 402.7 GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 7:19
PROSECTOR: NANCY DIEDRICH
RECORDER: JACK SERFORT
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN IBR) LIVER (LI) LUNG (LU) LF. TESTIS (TEO) RT. TESTIS {TE1) ACCESS/SEX ORG (SO)
2.1204 17.3502
1 7430 1.6996 1 7401 2.2761
.5265 X 4.3065 X
.432 X .4221 X .4321 X .5654 X
1.0000 1.1625
.1220 .1015 206 1 073
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
** P A T H O L O G Y KEYWORDS, SEVERITY. DISTRIBUTION
O B S E R V A T I O N S GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGCI ......................... GROSS: -ALL TISSUES/ORGANS NORMAL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN IBR). COAGULATING GLD ICG). L F . TESTIS (TEO). LIVER (LI). LUNG (LU|. PROSTATE (PR), SEMINAL VESICLE (SV). URETHRA (UR)
fsvzoo
CwCMO
HA2LETON LABORATORIES AMERICA. INC. MADISON. WISCONSIN US.A.
APPENDIX D INDIVIDUAL ANIMAL PATHOLOGY DATA
HWI 6329-100 PRINTED: lt-OCT-91
PAGE: 325
ANIMAL NUMBER: C67770
SEX: MALE
DOSE GROUP: $
SACRIFICE STATUS: SCHEDULED. FIRST INTERIM SACRIFICE
DATE OF DEATH: 01/25/91
STUDY DAY OF DEATH: 37
STUDY WEEK OF DEATH: 8
TERMINAL BOOY WEIGHT: 362.5 GRAMS
DATE AND TIME OF NECROPSY: 01/25/91 1:53
PROSECTOR: JULIE A. LARSEN
RECORDER: JILL SEVAN
POST-FIX WEIGHER: NOT AVAILABLE
PATHOLOGIST: DR. TOM PALMER
WEIGHER: PATHOLOGY DEPARTMENT
ORGAN NAME
ABSOLUTE ORGAN WEIGHT (GRAMS)
ORGAN WEIGHT RELATIVE TO BODY WEIGHT (X)
ORGAN TO BRAIN WEIGHT RATIO
ORGAN STATUS
BRAIN fB R 1 LIVER (LI) LUNG (LU) LF TESTIS (TEO) RT. TESTIS (TE1I ACCESS/SEX ORG (SO)
2.0136 13.0996
1 5011 1.5705 1.4155 2.6226
.5555 X 36137 X
.4141 X .4332 X .4098 X .7235 X
1 0000 6.5058
.7455 .7799 .7377 1 3024
WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN WEIGHT TAKEN
ORGAN NAME
P A T H O L O G Y KEYWORDS. SEVERITY. DISTRIBUTION
O B S E R V A T I O N S GROSS FREE-TEXT COMMENTS / HISTOPATHOLOGIC FINDINGS
GENERAL COMMENT IGC1 ........................................................................
GROSS: -ALL TISSUES/ORGANS NORMAL
LIVER |LI) ..................................................................................
MICRO: -SLIGHT. FOCAL
-INFILTRATES.MONONUCLEAR CELL
THE FOLLOWING TISSUES WERE UNREMARKABLE AT MICROSCOPIC EXAMINATION: BRAIN (6R|, COAGULATING OLD (CG|, LF. TESTIS (TEOI, LUNG (LU). PROSTATE (PR). SEMINAL VESICLE (SV). URETHRA (UR|
CO
*
HWI 6329-100 APPENDIX E Quality Assurance Statement Individual Hormone Analysis Data
620
00238^
HAZLETON
WASHINGTON
9 2 0 0 L E E S B U R G PIRE VIENNA. VIRGINIA 32'93
QUALITY ASSURANCE UNIT
LAOdAIOry Sconces C o "X nv
HWI 6329-100
Project No. : 2200-164_______ ____________________________
Project Title: rLH; rapid Estradiol: rapid Testosterone
Assay Run No.: 17.18.19.20.22.23.86.87.88.90.92.1266.1277,1293 ,
1294a P 4
This report has been inspected by the Quality Assurance Unit and accurately reflects the data generated during the conduct of the study.
In sp e c t i on/cate.
2/28/91 4/29,30/91 4/30/91; 5/1/91 5/1,2/91 6/12/91 6/12/91
Findings Reported
2/28/91 5/7/91 5/3/91 5/6/91 6/12/91 6/14/91
Auditor
D. Bland B. Yeatts B. Yeatts B. Yeatts B. Yeatts B. Yeatts
Qu,ajlLi.ty Assu--rann--c-e---U-n-1i:<-t-u--. Christopher M. Lee b
C " t-) - 1 / Date Released
Uniltd S l i m
G i m n y . J * B * n . f t # n c U n < I 0 K " 9 0 o m
Phon# 7 0 3 8 9 3 - 5 4 0 0
Fai 703-759-8947 T#l#i B993 H A 2L A BS VINA
21
00238^
HWI 6329-100
In d iv id u a l Hormone Data Week 5
Animal Number
C67457 C67461 C67464 C67468 C67476 C67491 C67492 C67500 C67502 C67503
Estradiol (oa/mL)
<20.0 20.1
<20.0 <20.0 <20.0 <20.0 <20.0 <20.0 <20.0 <20.0
Testosterone ina/mll
0 ppm T-5180
77,000 106,000
25,000 48,000 211,000* 45,000 85,000 45,000 19,000 63,000
Luteinizing (nq/mL)
0.4 0.9 0.5 0.6 0.6 0.3 0.3 0.4 0.5 0.3
C67511 C67514
C67515 C67524 C67525 C67544 C67550 C67555
C67558 C67559
<20.0 <20.0 <20.0
20.7 <20.0 <20.0 <20.0 <20.0
21.3 <20.0
1 ppm T-5180
55,000 35,000 45,000 29,000 27,000 289,000*
-
36,000 64,000 16,000
0.4
1.0 0.7 0.5 0.9 1.2 0.4 0.5 0.7 0.4
C67562
C67S68 C67569 C67574 C67576 C76591 C67592 C67595 C67597 C6760I
<20.0 <20.0 <20.0 <20.0 <20.0 <20.0 <20.0 <20.0 <20.0
10 oom T-5180
63,000 28,000 117,000 60,000 66,000 85,000 47,000 16,000 82,000
0.6
0.6 0.4
0.6 0.5 0.5 0.6 0.5 1.0 0.6
a Ressay value.
C023Sjf
HWI 6329-100
I n d iv id u a l Mormone Data Week 5
Animal Number
C67627 C67630 C67632 C67633 C67636 C67640 C67648 C67654 C67659 C67663
Estradiol (Do/mLl
. 28.8 24.5 21.7 <20.0 <20.0 <20.0 <20.0 32.0 <20.0
Testosterone (na/mLl
30 DDm T-5180
25,000 46,000 82,000 39,000 42,000 16,000 76,000 82,000 43,000 51,000
Luteinizing (na/mL)
0.6 0.6 0.5 0.4 0.3 0.7 0.6 1.0 0.6 0.4
C67675 C67681 C67682 C67687 C67690 C67696 C67698 C67713 C67715 C67717
24.1 25.7 31.3 46.3 38.8 52.6 36.5 23.1 25.8 32.7
100 ppm T-5180
10,000 10,000 45,000 13,000 19,000 24,000 70,000 50,000 18,000 65,000
<0.3 0.4
0.6 0.5 <0.3 0.7 0.4
0.6 0.4 0.6
C67727
C67733
C67735 C67741 C67742 C67751 C67759 C67761 C67762 C67769
<20.0
<20.0
<20.0 <20.0
22.5 <20.0 <20.0 <20.0
20.1 <20.0
0 PPm T-5180b
7,000 48,000 104,000 40,000
7,000 63,000 26,000 22,000 82,000 22,000
0.3
0.6
0.5 0.7 0.3 0.7 0.4 0.7 0.5 0.9
b Animals were pair-fed with the high-dose animals throughout treatment.
623
C023Sg
HWI 6329-100
In d iv id u a l Hormone Data Week 8
Animal Number
C67455 C67458 C67463 C67466 C67472 C67478 C67481 C67484 C67495 C67498
Estradiol (DO/mLl
<20.0 <20.0 <20.0
22.6 <20.0 <20.0 <20.0 <20.0 <20.0 <20.0
Testosterone (na/mLl
0 DDm T-5180
28,300 50,100 149,700 29,800 34,300
4,820 30,700 32,500 40,700 64,700
Luteinizing (na/mLl
0.4 0.6 0.4 0.7 0.7 <0.3 0.4 0.5 0.6 0.6
C67512 C67531 C67532 C67539 C67540 C67542 C67545 C67554 C67557 C67560
<20.0 <20.0 <20.0 <20.0 <20.0
-
<20.0 <20.0 <20.0 <20.0
1 .PPm T-519Q
12,200 227,700*
68,400 33,100 18,500 19,900 14,700
7,430 73,200 24,000
0.4 0.9 0.5 0.6 0.5 0.7 0.4 0.7 0.5 <0.3
C67570
C67578 C67581 C67582 C67584 C6758S C67586 C67587 C67594
C67614
<20.0 <20.0 <20.0 <20.0
34.2 <20.0 <20.0 <20.0 <20.0
<20.0
a Ressay value.
10 ppm T-5180
2,840 50,600 44,300 35,300 86,300 24,100 15,900 41,800 22,800 35,900
<0.3 0.5
0.6 0.5 0.5 0.4 <0.3 0.4
0.4
0.3
624
CQ23$q
HWI 6329-100
In d iv id u a l Hormone Data Week 8
Animal Number
C67617 C67629 C67634 C67639 C67644 C67647 C67656 C67661 C67662 C67667
Estradiol (pq/rci)
20.4 34.3 23.9 34.1 24.4 <20.0 <20.0 <20.0 <20.0 37.3
Testosterne (no/mil
30 ppm T-5180
47,900 12,200 38,800 252,000* 286,200* 32,300
9,800 14,300 21,400 23,200
luteinizi (ng/tnll
0.4 0.4 0.4 0.6 0.4 0.5 0.4 0.5 <0.3 0.8
C67680
C67699 C67703 C67708 C67709 C67710 C67711
C67721 C67722 C67724
<20.0
<20.0 32.4
29.3 <20.0 <20.0 <20.0
32.4 33.7 55.0
100 ppm T-5180
26,100 73,900 91,700 25,900 35,800 26,600 62,000 37,000 134,800 43,000
0.6
0.6 0.5 0.7 0.3 0.4 0.4 0.6 0.6 0.5
C67728
C67729 C67734 C67737 C67739 C67743 C67750 C67752 C67753 C67768
<20.0
<20.0 <20.0 <20.0
20.6 <20.0 <20.0
20.6 20.4
<20.0
0 ODm T-5180b
42,400 11,500 23,200 47,400 10,700 18,000 26,300 10,800 138,800 15,000
0.4
0.5
0.3 <0.3
0.4
0.3 0.7 0.5 0.8 0.8
a Ressay value.
b Animals were pair-fed with the high-dose animals throughout treatment.
625
C0239
HWI 6329-100
Animal Number
C67460 C67470 C67473 C67475 C67485 C67487 C67488 C67499 C67504 C67505
C67507 C67519 C67521 C67523 C67533 C67535 C67536 C67549 C67553 C67556
C67563 C67564 C67571 C67596 C67598 C67607 C67608 C67611 C67613 C67615
In d iv id u a l Hormone Data Week 14
Estradiol (DQ/ml)
<20.0 <20.0 <20.0 <20.0 <20.0 <20.0 <20.0 <20.0 <20.0 <20.0
Testosterone (nq/mll
0 oom T-5180
32,200 37,200 48,200
7,960 21,200 17,200 24,100
8,820 30,600 18,300
Luteinizi (nq/ml)
0.5 0.4 0.4 0.4 0.4 0.3 0.4 <0.2 0.3 0.3
<20.0 <20.0 <20.0 <20.0 <20.0 <20.0 <20.0 <20.0 <20.0 <20.0
I ppm T-518Q
67,200 4,990
23,800 88,000 10,000 24,200 26,400 16,200 63,600 32,100
0.5 0.6 0.3 0.5 0.3 0.4 0.5 0.4
0.5 0.5
20.4
<20.0 <20.0 <20.0
22.2 <20.0
20.1
<20.0 <20.0 <20.0
10 ppm T-5180
22,200 30,400 19,000 43,400
7,850 50,300 16,100 76,400
6,230 42,900
0.4
0.3 0.6 0.4
0.3 0.6 0.6 0.6 0.3 0.3
626
C0239
HWI 6329-100
I n d iv id u a l Hormone Data Week 14
Animal Number
C67616 C67618 C67621 C67623 C67624 C67641 C67643 C67652 C67658 C67668
Estradiol (Dq/mtl
<20.0 <20.0 <20.0
23.7 29.6 <20.0 <20.0 <20.0 <20.0 <20.0
Testosterone (nq/mll
30 ppm T-5180
18,000 53,100 10,200 13,000
7,470 16,700 51,500 47,400 11,800
6,600
luteinizi (nq/mll
0.4 0.3 0.3 0.5 0.8 0.3 0.3 0.5 <0.2 0.7
C67672 C67673 C67686
C67688 C67691 C67695 C67697
C67700 C67712 C67720
<20.0 <20.0 <20.0 <20.0
25.4 31.7 24.6 31.0 <20.0 <20.0
100 ppm T-5180
7,670 7,420 29,700 3,560 23,500 27,800 42,000 2,480 39,700 20,300
0.3 0.4 0.5 1.8 0.5 0.5 0.3 0.5 0.3 0.4
C67732 C67744
C67746 C67747 C67748 C67749 C67754
C67756 C67760 C67767
<20.0 <20.0 <20.0 <20.0 <20.0 <20.0 <20.0 <20.0 <20.0 <20.0
0 ppm T-5180b
19,200 58,500
6,830 13,200 12,800 16,400 26,800
5,590 5,900 29,400
0.5
0.6 0.3 0.4 0.7 0.4 0.4 0.3 0.5
0.3
b Animals were pair-fed with the high-dose animals throughout treatment.
627
C0233^L
HWI 6329-100
Animal Number
C67453 C67456 C67483 C67490 C67496
C67508 C67516 C67534 C67538 C67543
C67567 C67575 C67579 C67589 C67593
C67626 C67628 C67637 C67664 C67670
C67674 C67678 C67683 C67694 C67701
In d iv id u a l Hormone Data Week 22
Estradiol (Do/ml}
<20.0 <20.0 <20.0 <20.0 <20.0
Testosterone (no/mLl
0 oom T-5180
7,480 10,800 11,300 8,850
5,140
Luteinizi (nq/ml)
0.4 0.4 0.3 0.5 0.4
26.0 25.7
34.9 <20.0 <20.0
1 DDm T-5180
21,800 15,500 . 17,500 23,600 30,000
0.4 <0.3
0.3 0.4
0.5
29.8 25.8 22.0 27.7 21.1
<20.0 21.0 33.5 21.4
<20.0
<20.0 <20.0
27.1 27.2 23.3
i0.BPm,T-$l&0
16,500 3,940 21,000 3,390 14,900
30 ppm T-5180
17,800 5,830 9,170 20,100 15,400
100 pom T-5180
29,500 8,190 6,130
101,000 34,500
0.5 0.7 0.4 0.4 0.5
0.5 0.4 1.1 0.3 0.4
0.7 <0.3
0.4 0.9 0.5
628
00239$
HWI 6329-100 APPENOIX F Results of Individual Test Material Residue Analyses
629
0239^
HWI 6329-100
Animal Number
C67457 C67461 C67464 C67468 C67476 C67491 C67492 C67500 C67502 C67503
Results of Individual Test-Material Residue Analyses Week 5 - Males
T-5180 fpoml
Group 1
Mean (opmi
a a
a a a a
C67511 C67514 C67515 C67524 C67525 C67544
Group 2
8.33 8.12 6.35 6.87 6.66 6.98 6.81 6.95 6.69 7.79 5.85 5.81
a Below the limit of detection.
8.23 6.61 6.82 6.88 7.24 5.83
630
C9239tf
HWI 6329-100
Animal Number
C67550 C67555 C67558 C67559
C67562 C67568 C67569 C67574 C67576 C67591 C67592 C67595 C67597 C67601
C67627 C67630
Results of Individual Test Material Residue Analyses Week 5 - Males
T-5180 (DDm)
Group 2 (Continued)
7.78
5.88 6.07 11.5
4.46 4.96
Group 3
-
46.4 45.5 54.8 56.2 57.3 57.3 41.2 41.6 54.1 54.5 53.2 53.7 64.6 65.9 65.4 67.2 58.9 59.8
Group 4
-
91.7 92.6
Mean (ppm)
-
5.98
-
4.71
-
46.0 55.5 57.3 41.4 54.3 53.5 65.2 66.3 59.3
92.2
631
C0239^
HWI 6329-100
Animal Number
C67632 C67633 C67636 C67640 C67648 C67654 C67659 C67663
Results of Individual Test Material Residue Analyses Week 5 - Males
T-5180 (ppml
Group 4 (Continued)
99.1 105
97.3 98.7 77.6 78.1 113 101 113 109 124 122 116` 117 89.5
Mean (ppml
102 98 77
107 111 123 117
-
C67675 C67681 C67682 C67687 C67690 C67696 C67698 C67713 C67715 C67717
Group 5
138 133 151 150 142 137 137 147 113 115 202 211 157 156 159 183 171 163 209 206
136 151 140 142 114 207 157 171 167 208
632
GQ239JT
HWI 6329-100
Animal Number
C67727 C67733 C67735 C67743 C67742 C67751 C67759 C67761 C67762 C67769
Results of Individual Test Material Residue Analyses Week 5 - Males
T-5180 (pptnl Group 6
Mean fppm)
a a a
a a
a
a Below the limit of detection.
633
00239.8
HWI 6329-JOO
Animal Number
C67455 C67458 C67463 C67466 C67472 C67478 C67481 C67484 C67495 C67498
Results of Individual Test Material Residue Analyses Week 8 - Males
I:.5180_ )
GrouD 1
-
a
-
a a a a -
a' a a a a
Mea_n_J pern)
* -
C67512 C67531 C67532 C67539 C67540 C67542 C67545
GrouD 2
6.46 6.97 8.04 8.13 5.26 5.36 6.85 6.77 7.22 7.89 -
6.51 7.55
a Below the limit of detection.
6.72 8.09 5.31 6.81 7.56 7.03
HWI 6329-100
Animal Number
C67554 C67557 C67560
C67570 C67578 C67581 C67582 C67584 C67585 C67586 C67587 C67594 C67614
C67617 C67629 C67634
Results of Individual Test Material Residue Analyses Week 8 - Males
T-5180 (ppm)
GrouD 2 (Continued!
10.1 9.96 7.70 8.07 7.55 7.82
Grouo 3
60.8 60.3 24.5 24.4 39.0 39.9 42.9 42.5 63.0 62.5 49.3 50.2 24.4 24.9 32.9 36.8 43.7 41.9 73.4 73.4
SrQup 4
89.3 93.3 105 107 81.7 85.7
Mean (ppm)
10.0 7.89 7.69
60.6 24.5 39.4 42.7 62.7 49.8 24.7 34.8 42.8 73.4
91.3 106 83.7
C0240G
HWI 6329-100
Animal Number
C67639 C67644 C67647 C67656 C67661 C67662 C67667
C67680 C67699 C67703 C67708 C67709 C67710 C67711 C67721 C67722 C67724
Results of Individual Test M aterial Residue Analyses Week 8 - Males
T-5180 (ppml
Group 4 (Continued!
105 106 84.5 88.5 49.9 48.5 79.1 82.2 64.3 63.4 60.2 61.6 145 144
group 5
138 161 113 112 144 141 83.4 83.4 137 152 173 180 139 135 157 170 155 181 203 218
Mean (ppm)
106 86.5 49.2 80.7 63.9 60.9 145
150 113 143 83.4 145 177 137 164 168 211
636
00240^
HW1 6329-OC
Results of Individual Test Material Residue Analyses Week 8 -- Males
Animal Number
C67728 C67729 C67734 C67737 C67739 C67743 C67750 C67752 C67753 C67768
T-5180 (pomi
Group 6
a a a a a
a a a a a
a a
Mean (pomi
a Below the limit of detection.
637
00240^
HWI 6329-100
Animal Number
C67460 C67470 C67473 C67475 C67485 C67487 C67488 C67499 C67504 C67505
Results of Individual Test M aterial Residue Analyses Week 14 - Males
1:5)80 (ppm)
Group 1
a a a a a a a a a a a a a' a a a a a a a
Mean fonml
C67507 C67519 C67521 C67523 C67533 C67535 C67536
Group 2
7.60 8.45 7.82 8.00 8.09 8.88 6.24 5.65 5.95 5.87 6.71 6.81 7.13 7.38
a Below the limit of detection.
8.03 7.91 8.49 5.95 5.91 6.76 7.26
<
638
CQ240^r
HWI 6329-ICO
Animal Number
C67549 C67553 C67556
C67563 C67564 C67571 C67596 C67598 C67607 C67608 C67611 C67613 C67615
C67616 C67618 C67621
Results of Individual Test Material Residue Analyses Week 1 4 - Males
T-5180 (ooml
Group 2 (Continued)
5.41 4.84 6.67 7.83 7.99 8.84
Group 3
51.2 49.9 3.6 38.1 32.2 32.8 38.0 37.6 65.0 62.8 21.9 22.2 58.8 60.6 33.9 35.7 39.4 40.3 33.1 34.1
Group 4
68.7 62.4 61.0 64.2 70.0 67.3
Mean (ppm)
5.13 7.25 8.42
50.6 36.9 32.5 37.8 63.9 22.1 59.7 34.8 39.8 33.6
65.5 62.6 68.7
639
0 0 2 4 Of
HWI 6329-JOO
Animal Number
C67623 C67624 C67641 C67643 C67652 C67658 C67668
C67672 C67673 C67686 C67688 C67691 C67695 C67697 C67700 C67712 C67720
Results of Individual Test Material Residue Analyses Week 14 - Males
T-5I80 (ppm)
Grouo 4 (Continued)
70.0 73.1 109 108 47.6 49.4 57.5 58.4 73.7 73.7 79.5 81.3 64.7 64.7
GrouD 5
136 133 65.8 66.9 104 102 180 177 167 150 139 149 164 157 166 176 130 129 124 132
Mean (DDm)
71.6 109
48.5 58.0 73.7 80.4 64.7
135 66.4 103 179 159 144 161 171 130 128
640
C0240^
HW 6329-100
Results of Individual Test Material Residue Analyses Week 14' - Males
Animal Number
C67732 C67744 C67746 C67747 C67748 C67749 C67754 C67756 C67760 C67767
T-5180 (ppm)
Group 6
a a a a a a a a a a a a a a a a a a a a
Mean (poml
a Below the limit of detection.
641 eo24o
HWI 6329-100
Animal Number
C67453 C67456 C67483 C67490 C67496
Results of Individual Test Material Residue Analyses Week 22 - Males
IiSlSO (ppm)
Group 1
a a a a a a a a a a
Mean (Doml _
C67508 C67516 C67534 C67543
' GfdMP 2
a a 1.18
1.21
a a a a
a Below the limit of detection.
1.20
( 642
00240J
HWI 6329-100
Animal Number
C67567 C67575 C67579 C67589 C67593
Results o f Individual Test Material Residue Analyses Week 22 - Males
IijiSP fppm)
group 3
0.511 0.462 0.191 0.222 a a 2.59 2.59 a a
Mean fppm)
0.487 0.207
2.59
C67626 C67637 C67664
group 4
1.52 1.53 2.59 2.60 0.771 a
1.53 2.60 0.771
C67683 C67694 C67701
group 5
a 2.43 2.58 2.41 2.36
a Below the limit of detection.
2.51 2.39
643
C0240g
HWI 6329-100 APPENDIX G Hethod Validation for FC-143 In Feed Method Validation for T-5180 1n Rat Srum
644
0 0 2 4 tXj
MP-APFO-MA
PAGE 1 OF 6 OATE: 01/04/91 REPLACES: Original SECTION: 6001
ASSAY TITLE:
FC-143 In Rat Feed
HWI 6329-100
AREA OF APPLICABILITY: Hazleton Wisconsin, Inc. Residue Chemistry
SCOPE:
This method 1s applicable to the determination of FC-143 in rat feed samples at levels of 1 to 100 ppm.
PRINCIPLE:
FC-143 1n the feed sample Is extracted Into 1sooctane/ether mixture under acid conditions, methylated, and determined by gas chromatography using an electron capture detector.
SENSITIVITY:
The sensitivity of this method is 1 ppm of FC-143 1n rat feed.
PRECISION:
The relative standard deviation 1s 21% at 1 ppm (n-5), 5.4% at 10 ppm (n-6), 7.7% at 30 ppm (n-6), and 3.4% at 100 ppm (n-6).
ACCURACY:
The average recovery 1s 85.1% at 1 ppm (n-6), 99.4% at 10 ppm (n-6), 100% at 30 ppm (n-6), and 96.9% at 100 ppm (n-6).
REFERENCES:
Method provided by 3N and modified at Hazleton Wisconsin, Inc. (HWI).
HWI Laboratory Notebook Nos. 3418 and 3450.
645
0 0 2 4 Id)
m p -a p f o -m a PAGE 2 OF 6 DATE: 01/04/91 REPLACES: Original SECTION: 6001
HWI 6329-100
APPROVED BY:
??n^la A- Tshabalala, PhO Staff Scientist Methods Development
REVIEWED BY:
Lf r t l L - K
Deborah L. Keller Manager
Quality Assurance Unit
lU U ilj^
(14780)
DATE: DATE: A 3 3 A a
646
C0241
MP-APFO-MA PAGE 3 OF 6 OATE: 01/04/91 REPLACES: Original SECTION: 6001 HWI 6329-100
SAFETY PRECAUTIONS:
Observe all standard laboratory safety procedures as outlined In the HWI Safety Training Manual.
FUNDAMENTAL EQUATIONS:
FC-143 (Ammonium perfluorooctanate) foneula: CF1(CF,),C00-NH+4
Nonadecafluorodecanolc acid (NOFDA) formula: CF,(CF,),COOH
INTERFERENCES:
There may be an occasional Interference peak that Is observed at the 1 ppm level. When 1t does occur, that sample must be reassayed.
QUALITY ASSURANCE:
Two standard curves, low and high, each consisting of a minimum of four points, are used for calculation.
APPARATUS:
o Volumetric pipettes, various sizes o Volumetric flasks, various sizes o Eppendorf digital pipettes, various sizes o Disposable scintillation vials, 20 ml o Horizontal shaker, Eberbach Corporation o Gas chromatograph with electron capture detector, HP 5890A, Hewlett
Packard o Autoinjector, HP 7673, Hewlett Packard o Integrator, HP 3396A, Hewlett Packard
Note: Equivalent equipment may be substituted.
REAGENTS:
o M1111-Q\ water o Isooctane, h1gh>pur1ty solvent, B i J o Ethyl ether, h1gh-pur1ty solvent, B & J o Perchloric acid, concentrated, ACS reagent grade, Aldrich o Hydrochloric acid, concentrated, GR, EM Science o 01azomethane solution In ether, prepared according to procedure
described In Aldrich Technical Information Bulletin No. AL-113.
Note: Equivalent reagents may be substituted.
647
00241^
MP-APFO-MA PAGE 4 OF 6 OATE; 01/04/91 REPLACES: Original SECTION: 6001 HWI 6329-100
TEST MATERIALS: o FC-143, Lot No. 115, purity 98%, 3M o Internal standard, (NDFDA), Lot No. 1120LX, purity 98%, Aldrich
PROCEDURE:
Preparation of Stock Standard Solutions
Solution A. FC-143 (20 uo/mL). Accurately weigh about 20 mg of FC-143 into a 1000-mL volumetric flask. Oissolve the solution and dilute 1t to volume with water. Store 1t at room temperature in a polyethylene bottle. Prepare fresh solution every 6 months.
Solution B. FC-143 (2.000 uo/mLl. Accurately weigh about 200 mg of FC-143 Into a 100-mL volumetric flask. Dissolve the solution and dilute 1t to volume with water. Store It at room temperature in a polyethylene bottle. Prepare fresh solution every 6 months.
Solution C. FC-143 1800 ua/wL. Using a volumetric pipette, transfer 20 mL of Solution 8 to a 50-mL volumetric flask. Dilute It to volume with water. Nix the solution thoroughly and transfer It to a polyethylene bottle. Store 1t at room temperature. Prepare fresh solution as needed.
Solution D. NDFDA fl.5 mo/mL1. Accurately weigh about 30 mg of NDFDA Into a 20-mL volumetric flask. Oissolve 1t In 90:10 v/v Isooctane-ethyl ether. Add 100 HL of perchloric acid and dilute the solution to volume with Isooctane-ethyl ether. Store 1t at room temperature and prepare fresh solution every 6 months.
Solution 1. J I B f Mi lS J H M ) . Using a volumetric pipette, transfer 10 mL of
Solution D to a 1,000-mL volumetric flask. Ollute 1t to volume with Isooctaneethyl ether. Mix the solution thoroughly and store 1t at room temperature. Prepare fresh solution as needed.
Prooiritlon jf MorXliw Solutions
Calibration standards. Following the scheme below, transfer aliquots of the appropriate stock solutions to separate scintillation vials containing 1 g of control rat feed, 4 mL of water, and 2 ml of hydrochloric acid. Mix the solutions thoroughly on a vortex mixer.
648
C024yr
MP-APFO-MA PAGE 5 OF 6 OATE: 01/04/91 REPLACES: Original SECTION: 6001
HWI 6329-100
Sol m i an
A A A A A A C C C C C
YolJflML Hi
25 50 100 200 400 600 25 50 75 100 150
Final Cone
0.5 1.0 2.0 4.0 8.0 12.0 20.0 40.0 60.0 80.0 120
Internal standard extractant (3.S ua/mL\. Using a volumetric pipette, transfer 100 al of Solution E to 1*1 volumetric flask. Ollute 1t to volume with Isooctane-ether. Store the solution at room temperature and prepare fresh
solution every 6 months.
Surot Priflirillsn
Weigh a 1-g feed sample Into a 20-ml disposable scintillation vial. Add 4 ml of water and 2 mL of hydrochloric acid. Mix the sample thoroughly on a vortex mixer.
SiBBll ixtnstlflfl
To each of the vials containing the standards and samples, add S ml of Internal standard extractant. Cap the vials tightly and shake for 2 hours at high speed on a horizontal shaker. Centrifuge and transfer 1-mL aliquots of the organic layer to separate autoinjector vials. Add 0.5 ml of the dlazomethane solution Into each of the vials. Cap the vials and mix the samples on a vortex mixer for 10 to IS seconds. Inject 2 pi of each sample Into the GC system.
ChrwBitMriafctc Condition
Column:
Injection port liner: Purge time, minutes: Carrier gas:
Flow rate: Make-up gas:
Flow rate: Injection port temperature: detector temperature:
5X phenyl methyl silicone, 0.31 pm 1.d. x 50m, 1.03 pm film, Hewlett Packard, Column No. 442-85-04 Splltless glass liner ON - 1; OFF 38 5X methane/95t argon 1 ml/mlnute 5X methane/95X argon
35 ml/mlnute
250*C
2S0*C
649
00241^
MP-APFO-MA PAGE 6 OF 6 OATE: 01/04/91 REPLACES: . Original SECTION: 6001
HWI 6329-100
Temperature program: Initial oven temperature:
Initial time Ramp A: Final temperature:
Ramp B: Final temperature:
Final time: Injection size:
40*C 10 minutes
5 'C/mlnute 160*C
25*C/m1nute 230*C
8 minutes
2 lit
Note: All conditions may be adjusted to optimize chromatography.
CALCULATIONS:
Compute the linear regression equation relating the peak height ratios of the
calibration standards to their respective concentrations 1n the feed. Using the peak height ratio of the sample feed 1n the appropriate linear regression equation, compute the dose concentration In ppm as follows:
ppm FC-I43 - (y -b)/n x F
where y - peak height ratio of the sample feed b Intercept from the appropriate linear regression equation m slope from the appropriate linear regression equation (1/ppm) F calculation factor (1/fi)
G weight of sample feed measured out for extraction (g)
Example:
For a 1 ppm sample, y 0.159 b - 0.08895 m - 0.084
6 - 1.0222
ppm FC-143 (0.159 - 0.08885)/0.084 x ___ L _ - 0.810 1.0222
Average % recovery (Average amount found/amount claimed) x 100
Example: For a 1-ppm sample, average % recovery (0.851/1.00) x 100 85.1
650
C0243j
MP-APFS-HA PAGE 1 OF 7 DATE: 03/05/92 REPLACES: Original SECTION: 6011
HWI 6329-100
ASSAY TITLE:
FC-143 in Rat Serum
AREA OF APPLICABILITY: Hazleton Wisconsin, Inc. Residue Chemistry
SCOPE:
This method is applicable to the determination of FC-143 in rat serum samples at levels of 1.0 /ig/mL to 12.7 /ig/mL.
PRINCIPLE:
FC-143 in the serum sample is extracted into isooctane:ethyl ether mixture under acid conditions, methylated, and determined by gas chromatography using an electron capture detector.
SENSITIVITY:
Sensitivity described as the lowest fortification level that was validated, is 0.7 /ig/mL of FC-143 in rat serum.
PRECISION:
The within day standard deviation (n3) for FC-143 in rat serum is 0.3% at 0.794 /ig/mL, 2.7% at 1.56 /tg/mL, 1.7% at 3.18 /tg/rnL, 0.7% at 4.76 /ig/mL, 0.9% at 6.35 /ig/mL, 2.9% at 7.94 /ig/mL, 0.9% at 9.53 /ig/mL, and 0.4% at 12.7 /ig/mL.
The between days standard deviation (n-6) for FC-143 in rat serum is 10.1% at 1.56 /ig/mL, 10.8% at 3.18 /ig/mL, 10.2% at 4.76 /ig/mL, 10.2% at 6.35 /ig/mL, 10.1% at 7.94 /ig/mL, 9.5% at 9.53 /ig/mL, and 8.4% at 12.7 /ig/mL.
ACCURACY:
The average recovery 1s 99.9% at 0.794 /ig/mL (n-4), 99.9% at 7.99 /ig/mL (n-5), and 97.3% at 149 /ig/mL (n-5).
REFERENCES:
Method provided by 3M and modified at Hazleton Wisconsin, Inc. (HWI). HWI Laboratory Notebook Nos. 3418 and 3450.
651
MP-APFS-MA PAGE 2 OF 7 DATE: 03/05/92 REPLACES: Original SECTION: 6011
HWI 6329-100
APPROVED BY: vJ U Mandla A. Tshabalala, PhD Staff Scientist Methods Development
___
DATE: 3 "
REVIEWED BY: h Shfrry rT W . ' T 'etsel
X /Ayiianager Quality Assurance Unit
652 co? *
MP-APFS-MA PAGE 3 OF 7 DATE: 03/05/92 REPLACES: Original SECTION: 6011 HWI 6329-100
SAFETY PRECAUTIONS:
Observe all standard laboratory safety procedures as outlined in the Hazleton Wisconsin Safety Training Manual.
INTERFERENCES:
There may be an endogenous Interference peak that elutes around the retention time for PC-143. This may be overcome by appropriate dilution or be dampened with control blank serum.
QUALITY ASSURANCE: A standard curve consisting of a minimum of five points is used for calculation.
APPARATUS:
Volumetric pipettes, various sizes Volumetric flasks, various sizes Eppendorf digital pipettes, various sizes Disposable 12 x 75 mm polypropylene test tube (with cap) Horizontal shaker, Eberbach Corporation Gas chromatograph with electron capture detector, HP 5890A, Hewlett Packard AutoInjector, HP 7673, Hewlett Packard Integrator, HP 3396A, Hewlett Packard
Note: Equivalent equipment may be substituted.
REAGENTS:
Milli-Q water Isooctane, high-purity solvent, Burdick & Jackson Ethyl ether, high-purity solvent, Burdick & Jackson Perchloric acid, concentrated, ACS reagent grade, Aldrich Hydrochloric acid, concentrated, GR, EM Science Diazomethane solution 1n ether, prepared according to procedure described
in Aldrich Technical Information Bulletin No. AL-113.
Note: Equivalent reagents may be substituted.
653
-3
MP-APFS-MA PAGE 4 OF 7 DATE: 03/05/92 REPLACES: Original SECTION: 6011
HWI 6329-100
TEST MATERIALS:
. FC-143, purity 98%, 3M Internal standard, (NOFOA), purity 98%, Aldrich
PROCEDURE:
Preparation of Stock Standard .Solutions
Solution 0. FC-143 (320 uq/mL). Weigh 16 mg of FC-143 into a 50-mL volumetric
flask. Dilute it to volume with water. Store at room temperature in a polypropylene centrifuge tube. Prepare fresh solution every 6 months.
Solution H. NOFDA (1.7 mq/mL). Weigh 43 mg of NDFDA into a 25-mL volumetric flask. Dissolve it in isooctane:ethyl ether (90:10,v/v). Add 100 til of
perchloric acid and dilute the solution to volume with Isooctane:ethyl ether, ether. Store at room temperature and prepare fresh solution every 6 months.
Preparation of Working Solution
Internal Standard Extractant (1.6 iw/mLl. Using a volumetric pipette, transfer
1.0 mL of Solution H to a l-l volumetric flask. Oilute it to volume with isooctane-.ethyl ether. Store the solution at room temperature and prepare fresh solution every 6 months.
FC-143 Standard Solution. Following the scheme below, transfer aliquots of the
appropriate stock solution to separate 25-mL volumetric flasks. Dilute to volume with Mill 1-Q water. Store at room temperature in polypropylene centrifuge tubes. Prepare fresh solution as needed.
Standard Number
Stock Solution Concentration
(uq/wLl
Aliquot Volume fmL)
Dilution Volume (mL)
Final Concentration
(ixa/mL)
P-1 320 10
P-2 320 8 P-3 320 7 P-4 320 6 P-5 320 4
25 128
25 102 25 89.6 25 76.8 25 51.2
CQ24f
MP-APFS-MA PAGE 5 OF 7 DATE: 03/05/92 REPLACES: Original SECTION: 6011
HWI 6329-100
Standard Number
Stock Solution Concentration
iua/mU
Aliquot Volume imLl
Dilution Volume ( m U
Final Concentration
(ita/mL)
P-6 320 3
25
P-7 320 2
25
P-8 320 1
25
P-9 320 0.5 25
38.4 25.6 12.8
6.40
Preparation of Matrix Standard Curve
Pipette a 100-/iL control serum Into a 12 x 75 mm disposable polypropylene test tube (with cap). Fortify with 10 pi of standard solution and mix. Add 100 til of
Milli-Q water and 50 ii perchloric acid and mix.
Sample Preparation
Pipette a lOO-jtL serum sample Into a 12 x 75 mm, disposable polypropylene test tube (with cap). Add 110 juL of M1111-Q water and 50 pL Perchloric acid. Mix the sample.
Note: For samples containing levels of FC-143 which exceed the standard curve,
prepare a dilution of the original serum with control serum. The total volume of the matrix diluted sample taken for analysis should be 100 nL.
Sample Extraction
1. To each of the test tubes containing the standards and samples, add 2 ml of
Internal standard extractant, cap the test tube, and vortex vigorously (on a multiple vortexer) for 5 minutes.
2. Place the tubes in a horizontal position 1n a horizontal shaker.
3. Shake at high speed for 30 minutes.
4. Return the tubes to a test tube rack and allow to stand on a lab bench until the layers separate.
5. Transfer 1-mL aliquots of the organic layer (top layer) to separate autoinjector vials.
655
00242^
MP-APFS-MA PAGE 6 OF 7 DATE: 03/05/92 REPLACES: Original SECTION: 5011
HWI 6329-100
6. Add 0.25 mL of diazomethane solution into each of the vials.
7. Cap the vials and mix the samples in a vortex mixer for 5 to 10 seconds.
8. Inject 2 /iL of each sample into the gas chromatography (GC) system.
Chromatographic Conditions
Column:
Injection port liner: Purge time, minutes: Carrier gas:
Flow rate: Makeup gas:
Flow rate: Injection port temperature: Detector temperature:
5* phenyl methyl silicone, 0.31 /tm i.d. x 50 m, 1.03 iaI film, Hewlett Packard Splitless glass liner ON - 1; OFF - 10 5% methane/95% argon 1 mL/minute 5% methane/95% argon 35 mL/minute 250*C 310*C
Temperature program: Initial oven temperature: Initial time:
Ramp A: Final temperature:
Ramp B: Final temperature Final time: Injection size:
70*C 13 minutes 5*C/m1nute 95*C 25*C/m1nute 230*C 10 minutes
2 Ml
Note: All conditions may be adjusted to optimize chromatography.
CALCULATIONS:
Compute the linear regression equation relating the peak height ratios of the calibration standards to their respective concentrations in the serum. Using the peak height ratio of the sample serum in the appropriate linear regression equation, compute the dose concentration in ppm as follows:
656
MP-APFS-MA PAGE 7 OF 7 DATE: 03/05/92 REPLACES: Original SECTION: 6011
HWI 6329-100
ppm FC-143 - (y - b)/(m x F)
where:
y - Peak height ratio of the sample serum b - Intercept from the appropriate linear regression equation
m - Slope from the appropriate linear regression equation F - Calculation factor (100/V) V > Volume of sample serum measured out for extraction (til)*
657
*
