Document 101EM8K7462LvqdRNQmJEXKGK
V
HLOtlSS-^^'
Report To
E. I. duPont deNemours and Company On
The Contact Sensitizing Potential of Paint Samples 2 and 7
5935 - Enamel, White, Polyurethane 9350-350
5936 - Activator 9350-35C
5937 - Promotor 9350-35c
5948-----Enamel* White 183-508
5949 - Thinner. .3810
Submitted By
Albert M. Kligman, M. D. Ivy Research Laboratories, Inc. "T1 Philadelphia, Pennsylvania 19101
ca.&.^.SYoWS-.........
Unonou- C#r 3
4. Pus. Co^l S "3.0. Anr5
fe-ll.xf?. fttOTyiaii - P ip -
C11-5-fcFJ.
vvr v -a z ia .
.
' DECEIVED.
jar i HAStCai LABORATORr
STUDY SYNOPSIS
OBJECTIVE To evaluate the contact sensitizing potentialities of two paints.
MATERIALS
The two experimental paints were supplied by die Haskell Laboratories of the E. I. duPont deNemours and Company and were identified as follows:
Sample 2
Part A Part B Part C
H-5935 H-5936 H-59.37
Sample 7 Part A Part B
H-5948 H-5949
SUBJECTS
Twenty-five healthy adult males were utilized.
METHOD
The experimental paints were mixed according to the protocol directions two hours before application each day.
The experimental paints were applied to one-inch square skin sites on the volar forearms of all subjects for a total of fifteen applications on alternate days. A cotton tipped applicator was used to apply the paint. Before each new application the dried paints were removed by peeling. Following a two-week rest period the paints were applied to new skin sites and evaluated twenty-four and forty-eight hours later.
DUP040000882
RESULTS
The results are recorded in the accompanying tables.
No subject presented signs of having become sensitized. Daring induction some mild irritation was noted, usually erythema and slight glazing. Removing the paint each time may have contributed to this slight non-allergic inflammation. None of the subjects reported any itching, burning or other subjective symptoms associated with contact allergy.
CONCLUSIONS
Neither paint sample 2 or 7 induced any cases of contact sensitization. The contact sensitization capacity of these paints is very low and not likely to be a significant hazard under conditions of actual use.
Respectfully submitted,
- 2-
DUP040000883
E. I. duPont deNemours and Company Contact Sensitizing Potential of Paint Samples
- Subject Data -
je<
Initials Age Weight
Race
1
A.H.
45
195
2
H. 0.
31
170
3
J. W.
37
167
4
R. C.
23
150
5
Y. B. . ... 26
175
6
G.W.
48
165
7
H. CD
35
192
8
W.B.
30
178
9
S. V,
33
208
10
J. R.
28
159
11
B. H.
23
150
12
E. A,
48
175
13
H.M.
28
149
14
R. B.
34
145
15
B.T,
21
172
16
W.W.
47
180
17
C.E.
35
160
18
P. M.
32
165
N W W W N
w
N W N N W N N N N 1ST N N
DUP040000884
E. I. duPont deNemours and Company Contact Sensitizing Potential of Paint Samples
- Subject Data *-
Subject No. Initials
19 W. A. 20 C. B. 21 W.H. 22 B. G. 23 P. S.
24 w.c.
25 G. M.
Age
33 44 33 43 29 24 33
Weight
157 185 160 170 160 159 180
Race
N N N P.R, N N N
DUP040000885
PAINT SAMPLE 2
PAINT SAMPLE
PAINT SAMPLE
PAINT SAMPLE
si 4o->
s<D
m
DUP040000839
w
or 55
H co
A *#
.-.
o
o
o
o
a.. _
<1 .
w ># o 05
o
o
o
o
o
o
o
-f + .:
V+
lO
o . ,; _
O1 O. V - *
:v
-+ o'.f o -
V'" C: :)
-+
o.
' `o
:;;
'1 '-f-
.-'..
4-
;
`4*
CO o ' P
rH
o - - - pp:'r
+
CQ
, o ;'
4-
... ' -~--------
rrl
... '
. 4;
"f r'`
PAINT SAMPLE
r** +
4-
fcr r- .
o:
" '". .
- !>' 'J` 'l-.* '..~s
O
r-i
p
O
- + " ., ,,! . P"-' '
. v. '
.
.+
,
'+
Eh a> .
;
- o . . -
:;r, . +
Q p
o
" 4: .
Q o o o+ O/v O' O
o
oo
4
o o ( ^ ^_ . Q
Ol O .. .O '
2PS
o02
' Q
co O O . : O
O . .. O. .. . .
..
.
.....
4a<-D> ca co *t< ia . . . t- .. oo r--) 1
DUP040000890
PAINT SAMPLE 7
K E Y-
INDUCTION:
0 0+ I. 2 3 4
No reaction Faint erythema Brisk erythema Brisk erythema peeling Erosion Ulceration
CHALLENGE:
0 1 2 3 4
No reaction Erythema edema Erythema edema vesicles Erythema edema spreading tiered vesicles Tiered weeping vesicles
DUP040000892