Document 0wxgVByLDKyQNX7k1DzZ4NOd

FILE NAME: Neighborhood Exposures (NE) DATE: 2015 DOC#: NE001 DOCUMENT DESCRIPTION: Medical Journal Abstract - Mesothelioma in Quebec and Canada From: "Huff, James (NIH/NIEHS) [G]" <huffl@niehs.nih.gov> Date: March 14, 2015 at 8:31:40 PM EDT Subject: Malignant Mesothelioma in Quebec Canada From 1984 to 2007, Projections From 2008 to 2032 incidence of Malignant Mesothelioma of the Pleura in Quebec and Canada From 1984 to 2007, and Projections From 2008 to 2032 Alfreda Krupoves, PhD ,1 Michel Camus, PhD ,2 and Louise De Gui re, MDl,2 lDirection des risques biologiques et de la sant au travail, institut national de sant publique du Quebec, Quebec, Canada 2Departement de sant environnementale et sant au travail, Universit deMontreal, Quebec, canada Background continuous increase in male incidence of malignant mesothelioma of the pleura (MMP) despite the drop of asbestos production since 1980 in Quebec motivated this study aiming to assess when the rates of MMP will decli ne. Methods Age-standardized rates and trends were estimated over the 1984-2007 period Page 1 unti tied by sex for Quebec versus "Canada-excluding-Quebec" (Can-Qc). An age-cohort regression was used to make projections for 2008-2032. Results Average rates of MMP in Quebec men and women were significantly higher than in Can-Qc. Projected rates peak between 2003 and 2012 in all four study populations and decline thereafter. Conclusion The higher MMP rates and observed/projected time patterns in Quebec men are consistent with past asbestos production and occupational exposures. The excess in Quebec women may also be explained by domestic and, for some, by neighborhood exposures. To pursue the decrease in MMP rates beyond 2032, efforts to reduce asbestos exposure should be maintained. Am. 3 . Ind. Med. 2015 Wiley Periodicals, Inc. Page 2