Document 0qaDRLrYnzmJJ6dyQzMZJJLZb

O' i ' ! o i -- - r-' Dr*. 3 iaiu.31 Ru bIn 333 ?at ap 3Co Avenue Balt im or e, Maryland ' Dear Doctor Rubin : At t h e r e q u e s t o f my a s s o c i a t e D r . L. J . Sc h r a d i n , I am se n d i n g you h e r e w it h th e r s 3 u l t 3 o f ou r a n a l y se s on sam p le s o f u r in e an d b l o o d o b t a i n e d fr om t h e gr ou p o f men in v o lv e d in t h e e ,lo an in g o f a go s o l .hie st o r a g e t a n k a t t h e C u r t i s Bay T e r m in a l o f t h e T id e w a t e r A s a o e l a t e d v x l woiup a y . A few camnonta ar e j u s t i fie d In ccn n sction w ith th ese d at a. F i r st , the blood f i n d i n g s on t h e gr ou p o f f i v e men who e r e m o st se r io u sly exposed are u n iform ly low as compared to th e r e su lt s obtain ed in case s of in organ ic lead poison in g o f c o r r e sp o n d in g s e v e r i t y . The r e s u l t s a r e i n good agreem en t fo r th e two m eth ods o f a n a l y s i s , alt h o u gh I n t h e on e i n s t a n c e o f '>V. T . Yv lt t e r , v;e a r e d e a l i n g w it h a somew h at l a r g e r a n a l y t i c a l v a r i a t i o n t h an i s o r d i n a r i l y se e n . The a v e r a ge o f t h e se two r e s u l t s in e ach i n st a n c e can be a c c e p t e d a s somewh at mere accu r at e th an e it h e r sin g le r e su l t alo n e . In any case th e blood v alu e s ar e low as compared to the u r in ar y . v a l u e s , e x c e p t In t h e c a se o f . R o g a l s k l who, p r e su m a b ly , had ver y l i t t l e a c t u a l e xp o su r e . Th is d iscr e p an cy betw een th e b lood and th e u r in ar y r e s u l t s i s c h a r a c t e r ist i c o f t e t r a e t h y l l o a d p o i s o n i n g , I n w h ic h "c a se t h e l e a d com pound ton ds to be d ist r ib u t e d more w id ely, and e sp e c ia lly in the fa t t y t issu e s of the body, r ath er than to c o lle c t In h igh c o n c e n t r a t io n in th e b lo o d . Fo r h ap s ou t h i s accou n t, bu t p o ssib ly becau se of the d iffe r e n c e s in th e d ist r ib u t io n o f lead in the body in the case o f th i3 compound, th e u r in ar y le a d e x c r e t io n ten d s t o be con sid e r a b ly more r a p id th an in th e case o f In or gan ic lead p oison in g. For t h is reason the u rin ary concen t r a t i o n s i n se v e r e c a s e s a r e l i k e l y t o be v e r y much h igh er th an any valu e In in or gan ic le ad p oison in g. From o u r e x p e r ie n c e i t can be a c c e p t e d t h a t u r i n a r y valu es give th e b e st clu e to th e r e la t iv e m agnitude o f the le ad exp osu r e, and In th e case o f t h is group o f men, t h i s w ou ld seem t o be b or n e o u t by t h e o c c u p a t i o n a l h i s t o r i e s o f t h e men an d by t h e i r c l i n i c a l c o u r se . 2 Th ese a n a l y t i c a l d at a ar e o b v io u sly o f sc i e n t i fi c and academ ic I n t e r e st on ly in con n ection w ith th ese c a se s, h ut I fe l t you would pr ob ab ly be I n t e r e st e d in ou r in t e r p r e t a t io n o f t h e se r e s u l t s on th e b a si s o f ou r p r e v io u s ex perien ce . I f th er e I s an yth in g which I can do fo r th e b e n e fi t o f t h e se men, I would be g la d i f you would c a l l upon me. Very tr u ly you rs, h ober fc A. Ee h o e , M.D. 0021141