Document 0q4OvapQKLGm6O79d9mzrm2nR

aeptemer s, 1*5 Hr. 0. T. Bom union Caitlde Corporation SlUoonos Urlalon But Vasil Drive t vootard Atou ftnuandii Man Soak Our Mr. IMioi hu informed aa that yon ara dMlnw erf obtaining tddlttofltl tarUologlosl ant dawntalaginal Infer* nation far AroolorC123? iM utt. beyond that referred to la oar technical MUhb. Areolar 1232 - Aoata Axloltp Screening Data Metered undiluted fbm euvvlval tlna noat teethe In tna dajre. An toxic ilfn atra cheaply redeood appetite# lethargy, dlanrt-- and laereaelng ueakneee. At autopey# gram examination revealed renal and liver congestion u well u lafTwnatlnw of the gastrlo anooaa. By this roota of adalnlatretlou# this preparation am olaaaad u slightly toxin fee rata. ada Absorption - Venale Babbits - Applied andilutad intern bm. fca njntnal lethal daaa wan greater than laQO aad laaa than 2000 ag/fcg. Survival turn mm 4 to dare. Axle algae warn reduced appetite, gradual uasfeuv# lethargy# and vaatataaa after several daps to point of colleges. At autopsy# groee examination revealed 11 dlenoToration end puJamnary hyporanla. Wf this route of delnitration to rabbits# the preparation aa alldip toxlo. Ve have no data. OSW 020307 STLCOPCB4008236 Nr. o. ?. 2 2* 1969 - He her* not obtained ohronlo Inhalation 92. Bawiwr, it la ttaa opinion of our Medical Paparfmsnt that, IT anything, It would b laaa toxio than Areelev 1242. This opinion la based on the fact that tho 46 per cant chlorinated material (Aroolor 1246) appooro to bo tho noot taxis of tho sorloo baaod on acuta taodalty data and subaeute darnel application. Aroelor 1242 - Acuta Toxicity Screening Data 1 Toxicity - Kata. Mixed Sax - Administered undiluted u*go wos8650 (7ol0-9775) mg/kg. The survival tine was from about 24 hours to 3 days with most of the deaths In 2 days. The toxic sign* were diarrhea, laaa of appetlta. increasing weakness, dyspnea and collapse. At autopsy, macroscopic examination revealed liver and renal hyperemia, hr this routs of administration, tho preparation was classed as practically non-toxic. Skin Abaoptlon : Femala Rabbits - Applied undiluted Intact akin. Tho tainiaal lethal dots was greeter than 794 and less than 1260 mg/kg. The survival tire was 4 to 10 days. Toxic signs ware poor eppotlto with marked weight loss, occasional squealing after several days, and collapse. At autopsy, macroscopic examination revealed a soft liver with light color and pulmonary congestion. By this route of adoiniatratlon, this preparation was classed as moderately toxio to female rabbits. - Those otudiea were conducted on tho clipped intact akin "oof mixed aax rabbits with tho preparation being emplooyysed as a 4 per cent solution la com oil. Three doe# levels were employed; namely, 3Q, 75, and 100 mg/kg/day for 20 days. The body weights of those receiving 50 tag/kg compared favorably with those of the treated control group. Slight adverse effects were noted during tho dosing of tho 75 mg/kg group. However, tho surviving oalo of this group regained tho slight weight loos duriiK the subsequent observation period. There were moderate adverse body weight effects in those receiving the 100 mg/kg dote. The mean lethal dose for this preparation by this route and doeing procedure was 75 mg/kg. The toxic signs exhibited by the 100 ng/kg doe# group were generalised inactivity, severe weakness, lassitude, and loss of appetite. HO untoward signs were noted in tho 50 mg/kg group. There DSW 020308 STLCOPCB4008237 Nr. C- T 3 t, 1*5 wars o slgolfloaot looil ikia roostlona aaM M Uf of tho 4m lmli. liaNais far Um Nal worn oooparabla to thru of tha trsatad ooatrala. Ttm bawatolagla data and moults of urlaa analysis for tha tost groqp of anlaala naapawl mil with thasa of tha tnatti oootmla. Thara mra no algnlXloaa* groaa or nlorosoopla pathslagiool tiaaua altarstlons notad taring tha tost anlaala aerLflond at tho oooalualoa of ttaa otody which vara attrlkwtad to absorption of tha toot notarial. Findings for tha toot anloola wort cooparabla to thoaa soon in tha trootad control aolaals. YWf fafaHtUgft SglftM Attaehad la a rsprlat of tha pwtiioation tm Toxioity of tha Yapora of Araalar I2td and Aroslor 12*. In addition to tha abora* m wlah to point out that tha Arsalara. whan la oontaot with haaaa akin, baro a dafattlag affaat slallar to that of mop organic solwaats. Thsrsfora, oara ahoold to axorolaod to aroid akin eoataot. IWpootad or Brolaagod skin oontaot oould lndooo a drying and oroofciiig of tho akin and tho possibility of a daraatltla. Slnoarsly, williau 1. Bant. Fh.9. TQocloologlat Msdloal Papartnant cot or. Hoary F. Swyth# dr. Nolion Xnstltwt* iikoo Fifth krona Pittsburgh, Panaaylvonla 15213 toot Nr. F. Stum - Haw York Nr. J. F. Lonabarg * How York Nr. Nr. V. R. aH.. Naddos - Haw York Foatorino - St. Louis DSW 020309 STLCOPCB4008238