Document 0gr65GRMg6YrB2vRBqbR3K9ek

May 24, 1971 i bll^Firbir Buffalo Dyo Plant Thora la roportod to bo aa artlclo la May, 1971, laaue of Cancar Boaaarch on *0000(0010 Baapoooo to Vlayl Chlorida" Author ladlestod la f.L. Viola. Xt will bo opprodatad If you eao arrange to havo photoprint aont to no (Boon M40 - DAB-1). An aaaoalng that yoor library taboo Coneor Rasaarch. V do not. VAKiarl W. A. Knapp Consultant-Toxicology AS1 000016554 3?/? WA. tit*** J1 '</ /*7*7 / f7/ /j+j/ \A^ cjo ^^/<L*_ C^ii yfsji / -* -A >/A* AA? ` /1 *T**- il - ^ r 4^4 / J?++-** 4*-+*~ 'JiLs*4 +**+/ ir- m 4SCHIFFERU J'Jj w- - ^ /"A~^ AS! 000016555 vjr/y f Ch/er'S& DATE: PHOTODUPLICATION ORDER J 0 U R N A L: 7?Z.-r/. afr.__________ A U T H 0 R: l/fn/a . 7? L*.', * / LM Tf VOLUM E: 6 / fr3 Y E A R: '776 P A G E /7V to / tS* REQUESTED B Y: CJ L 0 C A T I 0 N: ~2> A B /?>/*/ Q EXTENSlO N:_______ ________________ C 73 ^ cfS*/S-2~S? C'Hc^) DATE: 1L P, HOTODUPLICATION ORDER JOURNAL: AUTHOR: (S'C-Ctt / 7 tff 7. (7^ iMc CcmC VOLUM E: /~2- Y E A R:/f70 P A G E 23 SZ to REQUESTED B Y: L 0 C A T I 0 N: 7V3Z? EXTENSlO N:2J?V</ V /3 Z/Q ASI 000016556 > r*e* t in vitro. K* i * mcui^'d only |nviIIby In;. It ^Hfttcs in I'li V. N. W,.' , eiura anil pi-., . , Mcram'.ir, t .'at. Health V., nl. 1970. -IS s , were fed for 1 . ere then iup, t- is conducted. At g bones, livi r. V significant difS:,al Ca or abc,,*,.. i of I' by 1 be l,.,1 uiitrols. Altln.n ontents of tin- 1- significant itu r<- breaking lieul ` on bone stmi. \o significant tUf,, * i tllC soft tissui s , 1 at in the corre f tasc activity in t' act anil the at nl miparablc valin It i . artol on pyridine ; lant, Harold; h Iniv. Toronto. . 70, 48(8), 542 v di in dosage fors or 9-10 g, kg , icaloric amts. . ie ale. After nit increase in NAD eotien.. ; and NADl'Ii ic NAD + the NADU ' _ 11 ratio di pr. "When ^Wtotal NAD - ratio return., NAD PH ami n i after 6 wetk reversed after i of a test dose '. d, was follow..; \DH ratio 1 am! I Chronic EtOH m changes leading t 1<V tenzene and sonic B. (Biokhim. Lab., inst., Moscow, i 33(4). 409-Wl . and e-xylene, in ih y PhOH in rats am ene or one of its ; excreted with tne . tetrachloride-induced 0, Dianzam, M- \ Italy)- FEUS l/-o; (Eng). Antiovnlau phcnyl-Z'-phcnyh-iu i liver polyrihosoiia 1 e CCh had no effect ycloheximide prt'i vas suggested that tion may act at tii^ . m the caprolactam >' 1. Bavelova.t . a.. Gid. im. Ilrtsumiiu, 1-5 (Russ). Theeiu 5 (cyclohexane. O'C" oxime) was evaiinii with rats. The <-" d the total toxicity m ^^entafluoride. > Inst. Gig. - ( >70, 35(7), 2.V t* of SbFi for mice is ,nths to an av. coiicm and thyroid function,' 14--Toxicology Vol. 73, 1970 85994 and in cardiac, renal, and lung morpliol. The 85988h Pathology of vinyl chloride- Viola. P. Luigi (1st. - ' mn ncrmissiblc concii. was 0.3 mg of Sb/m3 if l'atol. Gen., Univ. Perugia, Perugia, Italy;. Med. Lai-. 1970, ' s 's. ;- John Howe Scott 01(3), 174-80 (Kngj. Twenty-five rats after being exposed to i Influence of cadmium compounds on the generative vapors of vinyl chloride (30,000 ppm) 4 hr/day 5 days a week for T-.eetkova, R. r. (Med. Inst. im. Sechenova, Mos- 12 months were sacrificed in lots at 20-day intervals. After 10 tT.'.c- Tr. Pm}. Zahnl. 1970,. 14(3), 31-3 (Russ). months some animals showed a decrease in wt. and aggressiveness i `it.'iluicd by various Cd cnmpils. on the generative to outside si11utili and disturbed equil. Thirteen aumals died ni females working with alkali storage batteries and from cardiorespiratory complications. Two animals died from i. ,i;ts eoiitg. Cd and 7m was studied. The women were hematuperitiiueum. Most of the animals showed pathol. de . . , (),, effect of Cd compds. in coneiis. of 0.03-33 mg/in3. generation of tlie brain, liver, kidneys, and thyroid. Six rats ,, ;-,s. do not affect the menstrual cycle, the course of showed histopathol. alterations of the skeleton. Degeneration ',vu! UTtn of delivery. However, the wt. of children of the skeleton and connective tissue was similar to that observed '.e females differed significantly from that of neonates in human acroosteolysis of the bands. L. D. Pagnotto ,! funalcs- Evpts. on rats divulged the functional 8S989j Pathomorphological changes in the lungs during , -i i, mi the cstrous cycle in females. The wt. of preg- experiments involving boron carbide and corundum dust. T , \|,ii ul to the aetion of CdSOi and the wt. of new- Brunshtcin, I. P.; Danilova, R. I. (Uzb. Naueh.-Issled. Inst. re signifin antly below that in control animals. The Sanit,, Gig. Frofzabol., USSR). Mcd.Zh. Uzb- 1969, (12), 40-2 , .-.rii rats horn to exposed female rats contained 2.5 (Russ), Male rats (1.5 month old) were given lionin carbide and is p Cd as those of the control animals. Within 3 corundum dust intratraclieally in a dose of 50 mg/ml of physiol, . r delivery 7% of control animals and 2fi% of treated saline. The dust of various dispersions contained about 90% titer 7 months' exposure to Cd the wts. of the pres A1*0). The animals were killed after 3, C, 9, and 12 months. s' , nitr.il animals were not different. G.Muacevic Intoxication with dust resulted in inflammatory processes with .. Action of the polycyclic aromatic hydrocarbon 3,4- peribronchial and perivascular sclerosis. Some animals had - r.e on isolated mitochondria of normal and tumor cells, catarrhal pneumonia. Tlie permeability of the arterial wall i. N. A.; I'etrikevich, S. B. (Inst. Chcm. Natur. increased and dystrophy of connective tissue, ,:u d by destruc M iwow. USSR). Izv. Aknd. Nauk SSSR, Ser. Bin!. tion of the procollagen complex, caused reticular pin ainosclerosis. ds 2d fRuss), Respiration of rat liver mitochondria ,\I Slavikova mis markedly inhibited by 3,4-benzopyrenc when 85990c Embryotoxic actions of trypan blue ir. mice in relation - j.f min at 20 in the dark, and even more so when to the time of administration. Schlucter, C. ,in-;. Toxikol., b" Mug-wave uv light. Only a slight effect of 3,4- E'arbenfabriken Bayer A.-G., t\ uppcrtib-IUbi-iV- , Gcr.). .i.i- obsd. under similaT conditions with mitochon- Naunyn-Schoiiedfbcrgs Arch. Phannakol. 197C. _ :7 '.,, 20-30 ii -areoina, presumably due to disturbances in tlie (Ger), Mice received 1 s.c. injection of tryo.... c 1 i mg, kg) . j -u m. Petr Skrabanek at days 6-14 of pregnancy. Injection at day y caused highest .selenium. Hogue, Douglas E. (Dep. of Anim. Sci., percentages of resorptions or malformations hiotably cxen- . Ithaca, N.Y.). J. Dairy AV*. 1970, 53(8), 1135-7 cephaly). Injection at days 8 to 14 cause grout,, rctsr h.. ,n. . : uiitv and deficiency in animals is reviewed with 27 J. Dm:-" `y BCJN 85991d Production of atherosclerosis in laihyriuc aortas of A. cumulation of manganese in rats during experi- rats. Hosoda, Yasuhiro; Suzuki, Minoru (Dep. o: Pathol., mese intoxication. Boyarizhicv, V.; Khalacheva, Baylor Coll, of Med., Houston, Tex.). Patl.nl. .'.hcroh !, 1970, flfup. Varna, Varna, Bulg.). J. Eur. Toxicol. 35(4), 267-79 (Eng). Weanling maiv rats receiving p-.ivcnopro- .'.J '5 (Fr). The distribution of Mil in various pionitrile funiarate (BAP.Vj (fj.4% ) for 3 v,\ik-, a.,ci .id an - i'.vci lfi<) mg Mn1+ (soln. of MnCli)/kg orally, atherogenic diet supplemented with 9.2% B/ P.\ to- w. and fur f!d flays, was examd. In control animals, the with 0.1% BAJ'N for 9 weeks cxl.ioiiid gro- , , of of Mu was found in the adrenals; brain, liver, the aorta in as early as 3 week-., Lih.scctu. i, , . -orta . i, m.o' parietal bone followed in this order. Exptl. were filled with proliferating medial cells, a-.-; , ,do- . .- increased the concn. in all tissues, but it was highest thelial zone, the smooth muscle cells were n . ; .den bruin and lowest in liver. A correlation existed macrophages. Between ti.e test and control ,. of , accumulation of Mn and the duration of poisoning, the major serum lipid fractions were signifiear.tiy d.f tv ' ..,us Kurt H. Zingraf indicating that lathyritic changes of rat aortc' .i.ru^e only 7 Seel of alpha naphthyl isothiocyanate on the liver of active repair of damaged media but also enhance ::.tn . ! pid - ..lives. Gopinatli, C.; Ford, E. J. H. (Dep. Vet. deposition. vi Univ. Liverpool, Liverpool, Engl.), J. Pathol. 85992e Histological and histochemical pattern or '; of 1;, 269-SO (Eng). o-Xaphthyl isothiocyanate rats exposed to carbon disulfide. Gondzik, Maria d.a . '0, 4iJ, or 600 mg/kg, intragastrically) increased both Akad. Med., Szczecin, Poland). Patol.Pol. 1970. a, - , \TPa.e activity around tlie caualiculi and the sinus- (Pol). In rats poisoned by i.p. administration of Cs; ,d~. -56 25 .ph.utast activity, and decreased glutamate dehy- mg/kg every other day for 60-120 days), regressive, di vi., ...vc, nccinie tetrazolium reductase, and esterase activity and atrophic changes were obsd. ir. the spermatogem ..mm ; -!u-cp livers. In the serum, sorbitol dehydrogenase, and interstitial tissue when the 25 mg/kg dose was g! ,v. . re dehydrogenase, and arginase activity increased, than 60 days. Irreversibility of the changes was pe_tu..u- i. nrn. increased, and Bromsulplithalein clearance owing ANIT administration. Hepatic periportal Jerzy T.a- 85993f Pathogenesis of asbestosis. Szymezykicvi. ..i-.- i suclling, vacuolation, and loss of particulate staining, rad (Dep. Aerosols, Inst. Ind. Med., Lodz, Poland'. . . cd. ni iho above changes, chronic administration of ANIT Sci. Hist. Bull. 1970, 13(3), H5-19, 138 lEng). . . * . mg dsg/day) decreased the albumin-to-globulin ratio structure of chrysotile asbestos (T and quartz is revp f,.r ' :--i and caused intravascular red cell breakdown. their similar noxious biol. activities. Cryst. I eausei. ;... iry DZJN changes in guinea pigs characteristics for asbe-t. * Role of gastrointestinal absorption of kerosene in pro- amorphous I did not. Cryst. I and quartz suniiL\:u,i d i ;r.eur.ionitis in' dogs. Wolfe, Bruce M,; Brodcur, the O consumption of lung sections of while mice ...... t . Shields, J. B. (vSch. of Med., St. Louis Univ., St. globulin fraction of rabbit blood serum compared u .ih o.. r ... V ..I J. Pediat. 1970, 76(6), 867-73 (Eng). After amorphous I, coal dust, fiber glass, and (or) fine glr.--, . ,.v * ' .I- injected directly into the stomachs of 7 pups, none asbestos factory workers in the spinning and w.jvi-., . - u.als had any radiol. evidence of pneumonitis, while which have higher conens. of longer fibers, have a hici-. r ! e 5 of the 7 had histol. suggestions of edema. One had of asbestosis than workers in preparatory depts., where t . * . ;fringe. DCJN concn. is highest. ' ' 1 Solar simulator sunscreen evaluations in guinea pigs. 85994g Inhibition of the acute ethanol-induced :.,;.y . .. . o> . iinuel; Martin, Garland N\; Pieclmta, H.; Hockctt, 'fan, Margaret M. (Smith Kline and French Ltd., Gin.). J. Sac. Cost,,ft. Chcm. 1970, 21(8), 007-12 pyrazole. Morgan, J. C.; Dc Luzio, N'ichola-K . 8,. , )!,,!.. Tulauc Univ., New Orleans, La.), J'roe, Sn, ir.-: . ' 1970, 134(2), 462-0 (Eng). Since pyrazole vpeviii, - ..t sunscreen propns. contg. such active ingredients as liver ale. dehydrogenase and impairs tlie met.ibi !..;: . 1 '' -dinicthylaminobenzoate, homomenthyl salicylate, studies were undertaken in rats to cvaluau the "hen/oic acid, were evaluated on guinea pigs with inhibition of EtOH metabolism on the development of nl erythema both with and without washing after EtOH-induced fatty liver. Inagreementwitiiprcvio-.lv.. . On the nonwashed site, most of the sunscreens tions, 20 hr after EtOH administration a 5-fold increa-e i. P' tul from irradn. ranging from 1 min. erythcmal dose triglyceride concn. occurred. In marked contrast, tin MED's. When sunscreen sites were rinsed with and EtOH-trcatcd group showed complete inhibition , 1'janiyl-p.jV.TV-dimethylaniinobcnzoatc in 75% induced hepatic triglyceride accumulation. Tin : - .-iiydroalc. lotion with emollients and p-aminobenzoic the EtOII-induced hepatic triglyceride nc. , EtOH showed >50% protection at 1 MED; 2 of in the presence of enhanced blood EtOH cm - , . showed some protection from higher exposures. group. The CCh-indueed fatty liver and , DZJN eridemia was not modified by pyrazole, denoting s, .. > . AS I 000016557