Document 0gnoYEdQoZBn3KywJV43dRRzm

AR226-2854 IF; S Copies ,, , ,, , .E> 11 Pont de Nemours and Conroanv Haskell Laboratory for Toxicology and Industrial Medicine HASKELL LABORATORY REPORT NO. 1003-76 MR NO Material Tested Pi Haskell No. 10,642 Sample Ready for Testing Organic Chemicals department, Jackson Laboratory PRIMARY SKIN IRRITATION AND SENSITIZATION TESTS ON c p t n p a jd t p o sssaag?gsggs?=sgoef= Results: Concentration i. .istilled water Primary Irritation Test-24 Hours -48 Hours Challenge Test-24 Hours -48 Hours Sensitization Response Ratio** Re-Challenge Test-24 Hours -48 Hours Sensitization Response Ratio** Reactions* on Intact Guineal Pig Skin Test Areas (10 Animals - In. Avg. Wt, = 486 g Avg. Wt. = 778 g Re-challenge - Avg. Wt. = 798 g) 100% 10% (as received) i ---------- :------Cptrl Areas for Challenge Test (9 Nto Animals - Average Wt. = 732 g Re-challenge - Avg. Wt. = 764 g) 100% (as received) 10% 10 neg. 10 neg. 10 neg. 10 neg. 1++. 1+, 8 neg. 1++. 2+, 7 neg. 10 neg. 1+ 9 neg. 1+, 8 neg. 9 ng. 0/10 9 neg. 9 neg. I'*-*- 6+, 3 neg. 1+ 9 neg. 1+, 9 neg. 10 neg. 3+, 6 neg. 9 neg. 9 neg. 9 neg^. 0 /10 Company Sanitized. Does not contain TSC 2- - M M J h - 10,642) produced no irritation when tested as received (100%), and as a 10% aqueous solution on the shaved intact skin of male albino guinea pigs. At challenge one control animal had a very mild reaction to the 100% material while one test animal had a moderate and two test animals had mild reactions to the 100% material. A similar difference in response of test over control animals was seen when re-challenged. While the quantitative increase in erythema was not sufficient to call this material a sensitizer, the increase of test over control animals would suggest that it may be a very weak sensxtizer. Skin contact should be avoided, with immediate washing if contact should occur.* 'I 1 * Reaction, Code: + , + + , + + + = mild, moderate, strong erythema; -H-f+ = erythema plus fedema; +++++ = necro'sis. I ** Sensitization is defined as a significant score increase at challenge over the response expected from the same amount applied initially or on the concurrent controls. Composition: 1 NCG:ms Report No. 1003-76 Date Issued: January 14, 1977 Report by: 7,Nancy C. Goodman Technician Approved by: nond W. Morrow Chief, Dermal and Ocular Toxicology Section Company Sanitised. Does not contain TSCA CBS. m tiisSi