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CVfIZ& CHEMICAL MANUFACTURERS ASSOCIATION August 29, 1989 Dear Vinyl Chloride Panel Members: The Illinois Environmental Protection Agency is proposing a listing of air toxics within the State of Illinois. Listed chemicals will be subject to control requirements at a future date. Vinyl Chloride is one of the chemicals proposed for regulation by the Illinois EPA. Several groups within CMA are considering providing comments on this proposed listing of air toxics. If you would like to provide comments or need additional information, please call me at 202/887-1293. Sincerely, Susan K. Howe Manager Vinyl Chloride Panel CONFIDENTTat. 2501 M Street, NW, Washington, DC 20037 202-687-1100 Tele* 89617 (CMA W$H> CMA 010240 Illinois Environmental Protection Agency P.O. Box 1927S, Sprinftwid, il 62794-9276 BASIS FOR SELECTION OF AIR TOXICS CANDIDATES Distribution by CMA CHHMSTAR DIVISION From_ Ref. N( Date _ CONTENTS Legend and Abbreviations .............................................................................. 11 Selection Basis for 79 Air Toxics Candidates ..................................... I - 10 Literature References for 33 Non-Carclnogtnlc Air Toxics Candidates............................................................................ 11-13 Distribution of Toxicity Endpoints ......................................................... 14 Legend for Selection Basis Entries For carcinogens* the entries Include: - classification of carcinogenicity (source) classifications are either known or probable human carcinogens * sources Include one or more of the following sourcts* NTP - National Toxicology Program IARC - International Agency for Research on Cancer EPA - U.S. EPA Carcinogen Assessment Croup ACGIH - American Conference of Governmental Industrial Hygienists For non-carclnogenlc air toxicants* the entries Include: - acute lethality value (lethality score) - subacute value (subacute score) - systemic (toxic) effect [severity of effects score] lowest toxic dose value [lowest toxic dose score] (Integrated systemic toxicity score) Abbreviations mg/kg milligrams per kilogram mg/cu m * milligrams per cubic meter ppm * parts per million mg/kg-day * milligrams per kilogram per day Cat category COKPIDSr-- to Protect 1. ' *"\ Ross v. '.z.-.o-o, Inc..>v -7 14th District Court Calcasieu Parish, Louisiana U CHA 010242 5 > Z 0 T 0 VWO 7/31/B9 Basis for Selection of Air Toxics Candidates Option 2 31 Chewleal Selection Basis Acrylauide Probable Hunan Carcinogen (ACGIH) XXX Acrylic acid Air Toxicant, score *7.00 Acute: 33.5 ng/kg (3) > Subacute: 30 ng/cu (2) Systeulc: Lesions of nasal nucosa [nl id effect on Cat. Ill organ 2] 0 5 ppu [0.19 ng/kg-day - 4] (2.00) XX X Acrylonitrile Probable Hunan Carcinogen (NTP, IARC, EPA, ACGIH) X X XX Alkylated lead compounds Listed by International Joint Coamlsslon X X XX Aniline Air Toxicant, score 9.25 ' Acute: 250 ng/kg (2) Subacute: 10 ng/cu (2) Systeulc: Metheuogloblneula [definite effect on Cat. I organ 7] 0 5 ppu [6.3 og/kg-day - 3] (5.25) X XXX Arsenic and compounds Known Hunan Carcinogen (NTP, IARC, EPA) X XXX Asbestos Known Hunan Carcinogen (NTP, IARC, EPA, ACGIH) XXXX Benzene Known Hunan Carcinogen (NTP, IARC, EPA) XXXX Benzo(a)pyrene Listed by International Joint Couufsslon XXXX Biphenyl t; Jw lUKHTIAL nubjectTto Protective Order in Hobs v. Conoco. Ino.. No. 90-4837 14th Judicial District Court Calcasieu Parish,, Louisiana Air Toxicant, score 10.75 Acute: 2400 ag/kg (1) Subacute: 1.5 ag/cv u (3) Systealc: Central and peripheral nerve damage. liver dauage leading to acute yellow atrophy [severe effect on Cat. I organ 9] 9 5 ug/cu [1-08 ng/kg-day 3] (6.75) -1- 4 CHA 010244 CONFIDENTIAL Subject to Protective Order In Bobs t. Conoco, Inc.,, Ho. 90-4837 14th Judicial 111 strict Court Opti*Ufcleasieu Parish, Louisiana _2 ^3 _4 Chenlcal XXX Boron trifluoride XX X X XX X X 1*3-Butad1ene n-Butyl alcohol XX X X XX X X Cadnlun and compounds Caprolactan X XXX Carbon disulfide X XX X XX X XXX Carbon tetrachloride Chlordane Chlorinated dlbenzodloxlns Selection Basis Air Toxicant* score * 11.00 Acute; 1180 ng/cu n (2) Subacute: 3 ng/cu n (3) Systenlc: Pneunonltis [nlld effect on Cat. I organ * 6] B l.S ppn [0.98 ng/fcg-day * 4] (6.00) Probable Hunan Carcinogen (HTP) Air Toxicant* score " 6.SO Acute: 790 ng/kg (1) Subacute: ISO ng/cu n (1) Systenlc: Decreased hearing acuity [nlld effect on Cat. 1 organ - 6] B 80 ppn [7.5 ng/kg-day - 3] (4.50) Probable Hunan Carcinogen (HTP. 1ARC, EPA) Air Toxicant* score 6.00 Acute: 300 ng/cu n (3) Subacute: 1 ng-dust/cu n (3) Systenlc: none recognized (0.00) Air Toxicant, score 10.00 Acute: 25000 ng/cu n (1) Subacute: 30 ng/cu n (2) Systenlc: Significant vascular* nervous systen, and blochenlcal changes [definite effects on Cat. 1 organs 7J B 9 ppn [0.87 ng/kg-day - 4] (7.00) ^ Probable Hunan Carcinogen (RTF* IARC* EPA, ACG1H) Probable Hunan Carcinogen (EPA) Listed by International Joint CounissIon Option 1111 X X XX XXX X X XX X X XX XX X deleted w a rr- o ' o C+1 O O ooo 4 teS "f 715- a M d- ssj -3 ' <t> P--I ; - 1 tH -> ot 4 -i Co nz > oh) ut Chemical Chlorinated dlbenzofurans Chloroform Chromium and compounds Coal Ur volatiles Cobalt and compounds p-Cre$1dine Cumene hydroperoxide Cyclohexanone 2,4-D Selection Basis Listed by International Joint Commission Probable Human Carcinogen (HTP, IARC, EPA, ACGIH) Known Human Carcinogen (HTP. IARC. EPA) Known Human Carcinogen (AC61H) Air Toxicant, score * 9.00 Acute: no data (0) Subacute: 0.05 mg/cu m (3) Systemic: Lung Injury [mild effects on Cat. I organ ( . )* 6] 0 0.1 ppm [0.0036 mg/kg-day * 4] 6 00 Probable Human Carcinogen (HTP. IAHC) Air Toxicant, score 4.75 Acute: 1365 mg/cu m (2) Subacute: no data (1) Systemic: Pulmonary edema [definite effect on Cat. I organ * 7] 304 mg/kg [304 mg/kg-day 1] (1.75) Air Toxicant, score (.25 Acute: 32111 mg/cu m (0) Subacute: 100 mg/cu m (1) Systemic: Degenerative liver and kidney changes [definite effects on Cat. I organs * 7] 190 ppm (4.4 mg/kg-day - 3] (5.25) Air Toxicant, score 7.75 Acute: 370 mg/kg (2) Subacute: 10 mg/cu m (2) Systemic: Kidney Injury [minor effect on Cat. I organ - 5] 9 5 mg/kg-day [5 mg/kg-day 3] (3.75) -3- CHA 010246 CONFIDENTIAL Subject to Protective Order in Boss v. Conoco, Ina., Ho. 90-4837 14th Judicial District Court Calcasieu Parish, Louisiana Option 234 Chemical XXXX DDT X 4,4'-Diaa1nod1phenyl otter XX Dibutyl phtteUte X XXX X XXX X XX X X p-DIchlorobenzene Dleldrln D1<2-ethylhexyl) phtteUte Dlaethyl sulfate Dlaethylaalne X XX X XX XX 1,4-01 oxane Eplchlorohydrfn Ethyl acrylate Selection Basis Listed by International Joint Coamission Probable Hunan Carcinogen (DTP, IARC) Air Toxicant, score 8.00 Acute: 8000 mg/kg (0) Subacute: S ag/cu (2) Systeutc: Polyneuritis [alld effect on Cat. 1 oran ( . )* 6] 8 1.7 ag/cu a [0.11 ag/kg-dty 4} 6 00 Probable Hunn Carcinogen (DTP, EPA) Listed by International Joint Coamission Probable Hunan Carcinogen (NTP, 1ARC, EPA) Probable Huaun Carcinogen (NTP, IARC, EPA, ACGIH) Air Toxicant, score 6.50 Acute: 8371 ag/cu a (1) Subacute: 18 ag/cu a (21 Systealc: Liver daaage [definite effect on Cat. I orga" 6] t 97 ppa [12 ag/kg-day * 2] (3.00) Probable Huaan Carcinogen (NTP, IARC, EPA) Probable Huaan Carcinogen (NTP, 1ARC, EPA) Air Toxicant, score 6.00 Acute: 8925 ag/cu a (1) Subacute: 20 ag/cu a (2) Systealc: Drowsiness and headache [alld effects of Cat. I organs * 6] 9 50 ppa [27 ag/kg-day - 2] (3.00) -4- Option 12 3 4 XXXX Chemical Ethylene X XXX XXXX X Ethylene dichloride Ethylene oxide Fluorine XXX XXX XXX X X Formaldehyde Hexachlorobenxene Hexachlorocyclo' pentadlene o 3: > o * o M XXX N*l XXXX Hydrazine Hydrogen fluoride CONFIDENTIAL Subject to Protective Order In v Conoco, Inc, , No. 90 - 4837 14th Judicial District Court Calcasieu Parish,, Louisiana Selection Basis Air Toxicant, score * 8.00 Acute: 1090270 mg/cu n (0) Subacute: not listed (1) Systemic: Cholinesterase Inhibition [definite effect on Cat. I organ * 7] 3 mg/kg [0.24 mg/kg-day 4] (7.00) Probable Human Carcinogen (KTP, IARC, EPA) Probable Human Carcinogen (KTP. IARC, EPA, ACGIH) Air Toxicant, score 6.00 Acute: 144 mg/cu n (3) Subacute: 2 mg/cu m (3) Systemic: none recognized (0.00) Probable Human Carcinogen (HTP, IARC. EPA, ACGIH) Listed by International Joint Commission Air Toxicant, score 13.00 Acute: IS mg/cu m (3) Subacute: 0.1 mg/cu m (3) Systemic: Degenerative changes of liver and kidneys [definite effects on Cat. I organs * 7] 0 0.1S ppm [0.11 - 0.16 mg/kg>day * 4] (7.00) Probable Human Carcinogen (HTP, 1ARC, EPA, ACGIH) Air Toxicant, score 11.00 Acute: 1040 mg/cu m (2) Subacute: 2.5 mg/cu m (3) Systemic: Lung injury [mild effects on Cat. I organ 6] 9 17 ppm [0.53 mg/kg-day " 4] (6.00) -5- CONFIDENTIAL Subject to Protective Order in Boss v. Conoco , J no . Ho. 90 48 >DD V * ___ . -- . ~14th Judicial District Corn* Calcasieu Parish, Louisiana Option 123 i Chemical XX Isobutyraldehyde XX X X XX X X Lead and compounds Maleic anhydride XX X X XX Hercury Methyl methacrylate XXX X XXX X 4,4'-Methyleneb1s (PM*-dimethyl) benzeneamine Methylene chloride 4,4' -Methylene dlanallne Selection Basis Air Toxicant, score 6.50 Acute: 39500 mg/cu m (1) Subacute: not listed (1) Systemic: Hemoglomlnemla [mild effect on Cat. I C4950)* # 50 >/lts t2*7 >,9/k9-<,ay " 3] Probable Human Carcinogen (NTP, EPA) Air Toxicant, score * 6.50 Acute: 400 mg/kg (2) Subacute: 1 mg/cu m (3) Systemic: Increased susceptablllty to lung Infection and bronchitis [mild effect on Cat. I organ 6] i undefined concentration [? ng/kg-day 1] (1.50) Listed by International Joint Coomission Air Toxicant, score 6.50 Acute: 15350 mg/cu m (1) Subacute: 410 mg/cu m (1) Systemic: CMS effects (decreased neuronal firing rate) [mild effect on Cat. 1 organ - 6] 0 400 ppm [2.3 ng/kg-day - 3] (4.50) Probable Human Carcinogen (NTP) Probable Human Carcinogen (NTP, EPA, ACGIH) Probable Human Carcinogen (NTP) CHA 0 1 0 2 4 8 -6- Option 1 234 XXXX Chemical Methyleneb1s(phenylIsocyanate) (HB1) XX X X X HI rex Molybdenum trioxide XX X X XX X X Nickel and compounds Nitric acid XXXX 2-M1tropheno1 Selection Basis Air Toxicant, score * 6.00 Acute: 178 mg/cu m (3) Subacute: not listed (1) Systemic: Pulmonary fibrosis [major effect on Cat. I organ 8] 1 undefined concentration [? mg/kg-day - 1] (2.00) Listed by International Joint Commission Air Toxicant, score * 7.75 Acute: 125 mg/kg (2) Subacute: 5 mg/cu m (2) Systemic: Pneumoconiosis [minor effect on Cat. I organ 5] B 10 mg/m3 [1.3 mg/kg-day 3] (3.75) Known Human Carcinogen (NTP, IARC, EPA, ACGIH) Air Toxicant, score * 6.50 Acute: 170 mg/cu m (3) Subacute: 5 mg/cu m (2) Systemic: Increased susceptablllty to pulmonary Infection [mild effect on Cat. I organ 6] 9 undefined concentration [? mg/kg-day - 1] (1.50) Air Toxicant, score 9.00 Acute: 334 mg/kg (2) Subacute: not listed (1) Systemic: CNS effects (disruption of reflexes) [mild effect of Cat. I organ 6] 9 0.003 mg/kg-day [0.003 mg/kg-day - 4] (6.00) CMA 0 1 0 2 4 9 -7- CMA 010250 CONFIDENTIAL Subject to Protective Order In -3ss v. Conoco. Ine1L Wo. 90-4837 14th Judicial District Court Calcasieu Parish, Louisian^ Option i1 3 f Chemical XX 4-N1tropheno1 XX X X X 2-N1tropropane Peracetic acid X X XX Phenol XX Phosphorus X X XX X PCBs Selenium and compounds Selection Basis Air Toxicant, score 9.00 Acute: 250 mg/kg (2) Subacute: not listed (1) Systemic: CHS effects (disruption of reflexes) [mild effects of Cat. I organ * 6] P 0.00125 mg/kg-day [0.001 mg/kgday * 4] (6.00) Probable Hunan Carcinogen (NTP, IARC) Air Toxicant, score * 9.25 Acute: 450 mg/cu (3) Subacute: not listed (1) Systemic: Chemical bronchopneumonia [definite effect on Cat. I organ 7] P 1B6 mg/cu m [3.2 mg/kg-day r 3] (5.25) Air Toxicant, score * 11.75 Acute: 31$ mg/cu m (3) Subacute: 19 mg/cu m (2) Systemic: Severe damage to lung, heart, liver, and kidneys [severe effects on Cat. I organs 9] 25 ppm [1.3 mg/kg-day * 3] (6.75) Air Toxicant,* score * 9.00 Acute: 3.03 mg/kg (3) Subacute: 0.1 mg/cu m (3) Systemic: Bone changes [definite effects on Cat. Ill organs 31 0.05 mg/kg [0.05 mg/kg-day - 4] (3.00) Listed by International Joint Commission Air Toxicant, score * 8.00 Acute: 6700 mg/kg (0) Subacute: 0.2 mg/cu m (3) Systemic: CHS effects (socio-psychiatric dlstrubanc ) [minor effects of Cat. I organ * 5} 0 0.2 mg/cu m [0.02 mg/kg-day - 4] (5.00) ChA 010251 Option 1 234 Chemical Sodium fluoride XXXX Sulfuric acid XX X X XX X X Tetrachloroethylene Toluene 2.4dlIsocyanate (TDI) XXXX XXXX X XX X Toxaphene Trichloroethylene 1,2,4-Trimethylbenzene CONFIDENTIAL Subject to Protective Order in Boss v. Conoco. Inc., Ho. 90-483? 14th Judicial District Court Calcasieu Parish, Louisiana Selection Basis Air Toxicant, score * 8.00 Acute: 52 mg/kg (2) Subacute: 2.5 (for F) mg/cu m (3) Systemic: Bone injury (osteosclerosis) [definite effect on Cat. HI organ - 3] 0 4 mg/cu m [0.26 mg/kg-day 4] (3.00) Air Toxicant, score * 11.00 Acute: 510 mg/cu m (2) Subacute: 1 mg/cu m (3) Systemic: Slight pulmonary hlstopathology [mild effect on Cat. I organ * 6] P 0.38 mg/cu m [0.061 mg/kg-day 11 4] (6.00) Probable Human Carcinogen (NTP, EPA) Air Toxicant, score 12.00 Acute: 95 mg/cu m (3) Subacute: 0.04 mg/cu m (3) Systemic: Sensitizer leading to respiratory difficulty [mild effect on Cat. I organ 6J 0 0.01 ppm [0.0022 mg/kg-day - 4] (6.00) Listed by International Joint Commission Probable Human Carcinogen (EPA) Air Toxicant, score 6.50 Acute: 18000 mg/cu m (1) Subacute: 125 mg/cu m (1) Systemic: CMS (nervous anxiety) and respiratory difficulty [mild effect on Cat. I organ 6] 0 10 - 60 ppm total hydrocarbons [1.5 mg/kg-day 3] (4.50) -9- Option 12 3 4 XX XX XX XX Chemical 2,4,6-Trinitrotoluene Vinyl chloride Vlnylldene chloride Selection Basis Air Toxicant, score * 10.00 Acute: 795 mg/kg (1) Subacute: 0.5 mg/kg (3) Systemic: Liver damage [mild effects on Cat. 1 organ *(66.0] 09) 2.38 ng/cu m [0.15 mg/kg-day * 4} Know* Human Carcinogen (NTP, IARC, EPA, ACGIH) Air Toxicant, score * 7.50 Acute: 25175 mg/cu m (1) Subacute: 20 mg/cu m (2) Systemic: Liver and kidney damage [mild effects on Cat. I organs - 6] 9 25 ppm [5.8 mg/kg-day . 3] (4.50) LDH/A/014 CHA 0102S2 COKFIHENTIAL Subject to PxVcotWo Order In Ross v. Conoco, i c., Nd. 90 -4837 lath Judicial Pi strict Court Calcsvieu Parish/ Louisian*# -10- Chemical Acrylic acid Aniline Biphenyl Boron trlfluoride n-ButanoI Carbon disulfide Cobalt Cyclohexanone 2,4-0 Dibutyl phthalate Dimethylamine References Reference Miller, R. R.; Fund Appl Toxicol 1:271-277 (1981) Oberst, F. W.; Arch Ind Health 13:379 (1956) Hakklnen, 1., S. Hemberg, P. Karll, and E. Vlkkula; "Diphenyl Poisoning In Fruit Paper Production", Arch Environ Health 26:70-74 (1973) Torkelson, T. R., S. E. Sadek, V. K. Rowe; "The Toxicity of Boron Trifluoride when Inhaled by Laboratory Animals", Am Ind Hyg Assoc J 22:263-270 (1961) Seitz, B.; Soc Med Hyg du Travail (April 10, 1972) Velasquez, J.; Med del Trabajo 1:43 (1964) Mihail, J.; Arch Mai Prof 29:109 (1968) Kerfoot, E. J., W. 6. Fredrick, and E. Domeler; "Cobalt Metal Inhalation Studies on Miniature Swine", Am Ind Hyg Assoc J 36:17-25 (1975) Treon, J. F.; J Ind Hyg Tox 25:323 (1943) Hazleton Laboratories, 1983 Document Accession Number 251473, U.S. EPA, Office of Pesticide Programs, Washington, O.C. Mllkov, L. E., at al, "Health Status of Workers Exposeifto Phthalate Plasticizers In the Manufacture of Artlflcal Leather and Films Based on PVC Resins", Env Health Persp pages 175-176 (January, Dow Chemical Co., unpublished report (1964) CMA 010253 *11" CONFIDENTIAL Subject to Protective Order Ross v. Cor.oco, Inc. i Ho. 90-41; 14th Judicial District Court Calcasieu Parish, Louisiana Chemical Ethyl acrylate Ethylene Hexach1orocyc1opentadlene Hydrogen fluoride Isobutyraldehyde Maleic anhydride Methyl methacrylate Methylenebls(phenyl 1socyanate) Molybdenum trloxide Nitric acid 2-Nltrophenol 4-N1trophenol Peracetic acid CONFIDENTIAL Subject to Protective Orddf Ift aa_v. Conoro^jnc^so. 90-4837 14th Judicial District Court Calcasieu Parish,, Louisiana Reference Nemec, J. W., W. Bauer, Jr.; Klrk-Othmer Encycl Chem Tech. 3rd ed. Vol 1 pages 330-354,"John W1ey and Sons, N.Y. (1978) Krasovltskaya, M. L., L. Malyarova; Gig Sanlt 33(5), 7 (1968) Treon, J. F.; Arch Env Hlth 11:459 (1955) Largent, E. J.; Fluorosis. Ohio State University Press, Columbus, OH (1961) Svlntukhovskll, 0. A.; "Toxicological Characteristics of Iso Butyraldehyde", Tokslkol Gig Prod Neftekhlm Ncftekhlm Prodlzvod 187 (1972) Tanaka, S.; J Scl labor page 117, Japan (February 1976) Inncs, 0. L.; Neurotoxicol 2(3):515-522 (1981) Ann Occup Hyg, 21(2):121 (1978) Mogilevskaya, 0. Ya. (1963) In: Toxicology of Rare Metals, pages 12-27. Izrael'son, 77 I. (Ed.) Gosudarstvennoelsdatel'stvo Medltslnskol Llteratury, Moscow (Translated by Israely Program for Scientific Translation, Jerusalem, 1967) Falrhall, L. T.; Industrial Toxicology 2nd ed., Williams and HI1k^ns, bait(more, MD (1957) Trelger, P.; "Nitric Acid Fume Pneumonia", Ind Med 16:395 (1947) Makhlnya (1969) abstract only Ibid Helnze, W.; "Peracetic Acid Aerosol Effect In Long-term Use of Geniicldal Concentrations on Experimental Animals", Hiss, Z., Humbolt - Unlv. Berlin, Math - Naturalss Ralhe 33(5):513-517 (1984) 12< CMA 010254 Phenol Chemical Phosphorus Selenium m Sodium fluoride Sulfuric acid Toluene 2,4-diisocyanate 1,2,4-Trimethyl benzene 2,4,6-Trinitrotoluene Vinylidene chloride LDM/A/020/psf Reference Deichmann, W. B.; Am J Clin Path 14:273 (1944) Fleming, R. B. L.; J Ind Hyg Tox 24:154 (1942) Glover, J. R., B. Chlr; "Selenium and Its Industrial Toxicology", Ind Med 39:50 (1970) Williams, C. R.; J Ind Hyg Tox 24:277 (1942) Alarle, Y., W. M. Busty* A. A. Kruno, C. E. Ulrich; "Long-term Continuous Exposure to Sulfuric Acid Mist In Cynomolgus Monkeys and Guinea Pigs", Arch Environ Health 27:16-24 (1973) Elkins, H. B., G. W. McCarl, H. G. Brugsch, J. P, Fahy; "Massachusetts Experience with Toluene Di-Isocyanate", Am Ind Hyg Assoc J 23:265-272 (1962) Battlg, K.; Z Prav Med 1:389 (1957) Goodwin, J. W.; "Twenty Years Handling TNT In a Shell Loading Plant", Am Ind Hyg Assoc J 33:41-44 (1972) Patty's Industrial Hygiene and Toxicology 3rd ed. Vol. 2B pages3545-1550, Wiley and Sons N.Y., N.Y. (1981) ~E-oTs7sthv. Conn T 1Te 0rd9e0r-4gIn". -13- CMA 010255 SysUalc T*cUy Score - Severity of Effects Scorfeo Distribution of Toutcity Endpoints Score: t subjective symptoms *3d lesions-of MU) mucosa fin symptoms dilation nf blood vessels . bladder . blood stones alteration . skin abnorwlltles . osteoporosis . reduced growth . osteo sclerosis . nlnor blood changes ft . decreased MC . headache/ nausea/ dirtiness . fatty degeneration of liver . loss of concentration . Cat. I organ Injury . hectic contests . Cat. I organ dysfunction . Increased Cat. 1 organ weight decreased uptake of norepi nephrine dyspnea CMpgerated long workings Cat. 1 organ congestion ulcers 1ft narcotic effect histology of liver . decreased cholin esterase . bepato- , euphoria cellular susceptible vacuolization to pulnonary . significant Infection biochemical depression changes hearing loss . pulnonary asthMtic bronchitis . histology of histology or brain lung . decreased hepatemegally birth weight anemia with noter disrupt Im ns 1 effects of ref loses . asthmatic henogtoh- sensiti Inemta sation decreased . methemoglob pulmonary inemia compliance . kidney Cat. 1 organ tubular dengeratlM damage polyneuritis . broncho pneanMltlS pneumonia (K changes . hepatitis Jaundice . fetal organ nephritis wight change . focal anphysane fflJiMIV" pathy^ 89 bone narrow damage to suppression multiple Cat. I organ organs necrosis . hepatic pulmonary atrophy fibrosis respiratory CMS paralysis deterior ation reversible teratogenesis reproductive effects neuro- psychiatric effects fetal toiletty convulsions sterility emphysema aberration . decreased n 3>: sperm production Note: Reversible effects cm lower score. Multiple organ effects can raise score. 0 t0o1 tK -14- CHEMICAL MANUFACTURERS ASSOCIATION August 9, 1989 Osar Vinyl Chloride Panel Members: The California Air Resources Board (ARB) has identified vinyl chloride as a toxic air eontaainent. For their process of identification and regulation of toxic air contasiinents, they have produced a draft report of findings, We have received a copy of the preliminary draft report for vinyl chloride. Public review of this report includes two coament periods. The first comment period began on August 1, 1989 with the nailing of the draft report. Written comments are to be submitted to the California ARB by September 8, 1989. Comments received by the California ARB will be reviewed, compiled in Part C of the report, and where appropriate, the report will be revised. This revised report will be mailed to the public for a second and final review. A 20 day comment period will be given for this review. If the Panel wants to provide comments, they may contact the California ARB at 916/323-8543 for a copy of the Technical Support Document for Proposed Identification of Vinyl Chloride as a Toxic Air Contaminant. I will be contacting the Research Coordinators to schedule a conference call to discuss the retrieval of hlstopathologieal materials by the member companies for review of misdiagnosed angiosarcoma by Dr. Kamal Ishafc of the Armed Forces Institute of Pathology. Sincerely, Susan R. Howe - Manager Vinyl Chloride Panel CONFIDENTIAL ' Subject to Protective Order in Boss V. Conoco, Inc., Ho. 90-4837 L4th Judicial District Court V Calcasieu Parish, Louisiana CMA 010257 2501 M Street. NW, Washington. DC 20037 202-887-1100 Telex 89617 (CMAWSH)