Document 0gmN5wvB85oxke6dZnYa4vdnd

FHF V-*/ . ' August 3. 1933 Ur. Hugh. U. Jackson. Manager Industrial Health Program Johns -Manrllle Corporation 22 Xaet 40th Street New York 16, Now York Dear Hugh! Please find adorned memoranda esmcerolag laboratory studios on sack of th* fix subjects citod la pur latter of July 13. Delay in . forwarding these data to you was caused by racatioc schedules sad . other absences from the office of eerttite staff members. "We bare purposely in this stage deleted costs and starting time estimates as we wished to have a clarification of the technical aspects of the studies and a mutual agreement of procedure of research. The starting, dates and costs can easily be appended at a later date. I will be la New York a few days the week of August 10 and also August 31. If you sad Dr. Smith would like to hare me meet with you either ot those dates. I will be pleased to arrange lor U. , ,Xiade#fc .pfflff-aansl .r.egia^da^ _ Sincerely years. C. Richard Waimer, M* D, Managing Director Ca.W-.fnn cct Dr. Kenneth Smith cc of memorandum also enclosed to Dr, Smith ?A//t' k4- COPY INDUSTRIAL- HYGIENE FOUNDATION OF AMERICA. INC. MELLON INSTITUTE. 4400 EIFTH AVENUE Pittsburgh i*. p*. August 1, 19S3 MEMORANDUM ON RESEARCH PROJECTS FOR JO HNS -MAN VILUE CORPORATION Structure sad Dust Characteristics of Hy^Sogb _ A study of the structure sad dust characteristics at Hy-Sorto would require three steps (l) s*ny dUltactiet to 4ttirmU< If cty*UUUi (th stiles is present isi, It so, the ftissust (2) screen analysis to gif istwasUon ou the mount of {loss, sad (3) field studies to determine the amount oC dust actually disseminated lato tbs air uadar actual working condition*. Tbs first two Items srs simple routine procedures sad require a# special consideration. To conduct tbs ISsld studios it would bo necessary bo know companies which, aro using Hy-5erb and obtain tboir coopstation to porm.it sampling daring actual use o( tbs material. '"U would., M course. o possible to simulate working conditions but it is boliovod that actual in-plant lasts would boos grantor weight. * Laboratory toots bar# boon used in which the dissemination of dust is measured after the dust la dropped through a certain distance. Such toots provide valuable information whoa Studyiag several compounds In order to obtain comparative data. The results tor say one compound would be of >NQuTft'Al. HTUifNl FOUNDATION GW AMtSICA. (NC. I, relatIveiy litu* vein* unless it were possible to compare It to another com* pound, Since only one substance is involved this test might wU be emitted. Solstice Torieltr cf Marine and fresh tstsr Piatomaeawus Earth SUe* the iafsrmatlea desired Is relsttiro toxicity, the UtntrsctMl Insofflstioe test is veil suited (or this purpose, It is proposed, therefore, to study six dusts: ttmtly, oUaf>i, calcined, sad Qua-calcined surio* dlita- otesm earth, sad the cerrespoadlng. freeh water dlatomaceoti* eerth. The rat would be used me the experimental saimel aad the dust sdmlaistersd ia a . single dose, Sufficient animals would be need la each group to permit eaerU flee at 3, S aad 1Z month.* with ths remainder being held for 21 months. Thus, comparative information would be obtained on relative short-time- effects as well as long-time sffaets. The Relative Toxicttv ef Tsrious Asbestos Fibers Again, since the objective is to obtain relative toxicity data, the Intratracheal insufflation tests should give meaningful inform attoa. The pro cedure ia general, would parallel that for the mariae Sad freak water diatomscseeaearth previously outlined. The study could be limited te crecidoUte, hry*etile ' nod umoelte end we would wish te work closely with yen In selecting the material tor the test. 2a inoustmmu i*vi*n* i'ounoatio"i or amcwica. inc. Toxicity of htaaalra Doss by Iahalsilsp ot Ptotomlto *' It U bslis-rwi ths* tstormstton *UioW by to* latrnfcrschool toauC- . flatloc. U*U *f to* sarth praytotealy ssMlnai wocld giro * partial *nwr to this qaastto*. Periodic iatrmtracfcaal tosufflmtios UiU would fir* additions! information. Sewwror, actual tofeaUdan tssts would ho rqulr*d tor a mar* procU* ralo*ilo*u Th* dostgu of aqatpaamt far tost procedure Car *pesinj animals iatormtttontly to mass!** esocsstrstionj of th* dust cm rMuiUy bo sceompUshsd. In ordsr to h*r* a basis for comparison it atU W aacaasary to conduct chronic aapoaur**. ThLa, to taro, would aocoaaitat* ftotof a prnpor t**al tor to* chroaic **p**ars*. If to* intratracheal Uun*f~ QLadea tact* wr coadoatod lira*, to*** data wold V* helpful to *l*ctto* spoaur* larols. 8flf*mr, if (net toata aro Mt cg*lcM drat, U fa possi ble toot tolrmatto* arailabi* * mpesur** to todustry would prorid* to* **e- MW7 lnforasttoc. - Throshold X-iznlt tor yiuxC*icfa*d Piainmacooua Earth Products The threshold limits of S mlllloa partial** ft cubic loot for quarto *m ctobltitod from human aqptrtnct through Inhalation. So Car, n* m ha* trot a*tohUah*d a toxicity limit tor flhroaia-prodnctof tost through * animal oxporim--tarta*. B to* *C course, pocslbi* through animal sxporimsatattou to obtain csxcparatlT* result* which would b helpful la tadteailag to* poosibla xaagsi- - . < *9-*"' </A-<*/>/ h$ INOOVTMIAL. HYOIKNC *euNO*nON or AMWtO. W*r .4 bad* sf a threshold lor this tfuxt it coznptriJoa with silica dust* ?& problem l* particular w fssl sboaid bo girix rmiy earsfui Coasidsratiou bmloT* mttiu&pt tsg to #* tbs ^oootlott by sainssi perlms*Uiioo. Yblt* modoubtsdiy mssstfHgftil utl wotrtbwblU tolormsttos sssld b* sbtaiasd, * ears&i appraisal sf th* UmUttlaM *uch 4ta should bo sadsrsissd. Fosstbis RaUiioasfalp <f Asb*stasis acd Csacsr of tbs 3Lan| 'Tbs rao^ats published by csrtaja iarssflgstsra liuttftstiaj a high taci~ dose* of Jung csztcsr is psrssa* softsrfag fxwm *b*sissisT spparssily or* si rsrisoco with tho smpsriaocs of Mm* othar observers, Thsrs sro asvsrsl possible STpUnstioas (or tbt of thus* observations. St is possible thsi variation* Is the typu operation or tbs characteristics of (bo fiber may ptsy role. and confirmatory {sformstiou is asedod regarding tbs diagnosis of both tbs ssbsstasis sad tbs c*a**r of lung. Until tbs nscnsaary dots u* obtained. by must of ft scientific syidemiotogic itsfy, tbs dlffereac* of opinion wVU osstiaas ts salat, sad os csnetuciag srtdaaes will bs arattahle to either ids. It is paropossd, therefor*, tfcst lbs seedy to bo sadsxIsbso^eUX^m^udss I* A critics! review of tbs literature with detailed study of e*sss reportsd by Idsrwwether sad Hooper, Orbs slabs a high U*4ti*n** i long ssacor among workers showing ftWtto*U 2, A dotailsd study sf tbs operettas* to vUcl these workers wsre involved with reforests to tbs met lype d liber ts wbicb tbsy vsrs exposed, duration of npeioitt and information eUdft| ts age, m sad race. Result* /3&**** dtsv INOU*Tm*i. 1-rrOlK!M* ^OUMOATIOIS. AMCmCA. live. s. of Ki* propoaod ttetdy <an th* relstliro toxicity of clary*ettto, mznocite *od ero- cidoliU flborc would b- correlated with tfcla portion of tie anrroy, 3, 5Ut{tletI atudy of both cd carcinoma (Mu to dotoraiu* (ho boat* ob Which th diagnoai* woo made* ' 4. A parallel statUdeal atudy of a cafELciooUy largo group of uu({octod - workora to um w * control, Sriort uodortakittg tuck an oxtotuiv* it will b aacoaaary to dotormia* whether tho required m*m for iavaatigaiioc m tvtUablc, W would wiah to kaow bow many |U*U we night-hero Mem to, ood to whot oaetoat the iafonnatteu outlined Bboro might ho aeeuaaibie. _ It ia anticipated that a proper atady of thl* wrt would rareal infer* ,.. mattan portiuoat ta the problem of aaboeieeie, se watt oocootrfbating apoeific knowledge rogordiog thep*ibl ceoaoctioo between pulmonary caretaoma ad aabeataaia* ' </As/S/