Document 0gk5LZG9weqq1joq0ORz7drNm

AR 226 - 3270 472 dels --~ - AR 226 3290 `TRADE SECRET Study Title H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 5 of 5 `Laboratory Project ID: DuPont-11418 TEST GUIDELINES: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (AUG-1998) ~~ AuTHOR: Susan A. MacKenzie, V.M.D., Ph.D, D.A. BT. STUDYCOMPLETEDON: PERFORMING LABORATORY: August 1, 2003 E.L du Pont de Nemours and Company `Haskell Laboratory for Health and Environmental Sciences `Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 [-- Service Cope Novos fll ~ ------F-- e SpS opT --e-- ee-- ree LP ------ 9H:02.5D4a2y5:GavSaugbcehrSotnuidcy TinonRiactistywith One-Generation Reproduction Evaluations --~ DuPont-11418 --~ APPENDIX BB INDIVIDUAL ANIMAL SPANE DSPER RMAM TID COUNTS IN Py MALE RATS ~~ - 1256 `Company Sanitized. Doesnotcontain TSCA CBI 9H0--2D5a42y5G:avSaugbecShtoundiyciTnoxRiactistwyith One-GenertionReproducion Evaluations DuPont-11418 --~ INDIVIDUAL ANTMAL SPERM AND SPERMATID COUNTS (MILLIONS) IN 2, MALE RATS GROUP 1-0: 0 mg/kg/day Aneimeal Epididymal sperm cauda Testiecultar spermarteidgs testis essai0aa 2288800.86 973872..49 e504d 263.0 1010.5 1133310.s0 1815 8872.65 521 5se1s31a51 227599.045 1818095..58 665005 264.2 857.0 113366..28 136.8 782785 64.9 66635009715 223584..59 190377.736 113395061 665080 252.5 107519 16.8 8975..09 92.4 665069 264.2 18307 135.0 sills GROUP III-0: 10 mg/kg/day ANnuimnbaelr FerEpciaduiddaymal SPpeerrmG cauda TPeesrtitceusltairs spermaSotridsg testis --~ e66s5105337 226542..25 989589..95 65163 249.0 875.8 113383.059 137.4 8891.90 75 66655102061 225569..05 9171552..09 112250.87 esi2s 251.4 1067.2 1380 8829.04 87.8 66655001771 228538..74 1082269..12 113323031 665032 240.8 904.5 1381s 816.03 831 663997 258.4 918.7 13500 85.3 --~ -_ Ts Company Sanitized. Does not contain TSCA CBI 9H0:-2D5a4y25:GSavuabgcehSotnuidcyiTonxRiactistwyith One-Generation ReproductionEvaluations DuPont-11418 -- INDIVIDUAL ANIMAL SPERY AND SPERMATID COUNTS (MILLIONS) IN Py MALE RATS GROUP V-0: 100 mg/kg/day Animal a Epididymal cauSdperam Testicular spermhtaeetsirtdisss 6se5s013146 226576..70 1080975..25 665051 266.6 109302 1133290.11 13207 982..88 7400 e65s0i8z3a 225631..79 1905342.106 665078 273.6 1156.7 1123281025 126.5 s73l.s6 7611 e66s5o03s6 225395..50 11331260.87 65002 253.7 114603 1123960.82 13300 8894'as 985 65004 256.0 127500 1310 520 GROUP VII-0: 1000 mg/kg/day ANnuimnbaelr FerEpciaduiddaymal SPpeerrmg cauda TToerstitceusltairs spermaPteridgs testis ~~ 6s63e02s2 226359..47 9m291.2 1132940.15 665105 247.8 1230s 12106 88021.79 86.5 e6s5i1e0l2 2245471.32 1935258..94 665133 260.7 898.5 112286..90 184.0 8876.57 72.8 66655105973 225484..43 1819426..10 G630s9 259.5 1160.1 113268.78 1333 775132 2 758 665123 244.3 1086.4 1391 805 -- - Tiss Company Sanitized. Does not contain TSCA CBI 0H--2D5a4y25G;avSaubgcehvSotnuidcy TinoxRiaclistywith One-Generation Reproduction Evaluations Dupont-11418 APPENDIX CC --~ INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS IN Py FEMALE RATS e--------Te-------- ee-- e `Company Sanitized. Does not contain TSCA CBI 9102.5D4a2y5:GevSaubgeehSrtourdiyc iTnoxRiacittywithOne Generation Reproduction Evaluations DuPont 11418 -- INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS IN Py FEMALE RATS EXPLANATORY NOTES Notes Test Days 74-88 = Cohabitation period -- ------ T360- ee `Company Sanitized. Does not contain TSCA CBI 9H02-5D4a2y5G:avSaugbechSrtoundiyciTonxRiactistwyithOe-GeRenproeducrtiotnEvialuoatinons DuPont 11418 ~~ INDIVIDUAL ANTMAL ESTROUS CYCLE PARAMETERS IN GROUP 1-0: 0 mg/kg/day -- PERCENT PERCENT ANIMAL DANYUSMBOEFR DOAFTA DAYOSF IN DAYOSF IN PEDRACYESNTINOF NUMBER COLLECTION ESTRUS DIESTRUS PROSSTRUS 666655323240 221 2398%% sso2t8 211088 666655127557 665336 3252 34 3226%8 575188 208 74% 132% 38 666655213922 665307 225 21 3269%% s5678% ase 52% 1888 08 665246 ses280 23 21 ase ase a 208 2% 108 6s6e5s216845 665206 2211 21 3a8s%s 1587s% s5t% 388 6s 128 666655232066 2232 32078% 5552%8 178%% 666655129489 3201 22798% 6672%% 107%8 ~ 666655224800 665203 2213 2 3a0n8 651288 38 s08 E5Y% 7% Py FEMALE RATS MEALNENGCYTCHLE (days) 4.0000 44l.0000 44l0000 4l0000 5.00 44.l5000 44l.0000 54.0000 33.20s0 41.0000 300 PIRNETCEORIVTAALL (aays) :1 21 11 15 3 11 11 32 110 31 1 Noceovpiudleantcieoonfwcaospaulsastiuomnewtdaosbeftouhndabsuttsatlritutsedruwraisndgecloihvaebrietda.tioTno; ctahlecudlaaytseotfhpeePrrseicsotietnatldIiensttruesrtthvhateadflaoy,lloowfed ~ Evi`dweenrceeeoxfclcuodpeudlftrioomncdaeltceucltaetdi,obnusstiannciemtahl daindimnaolwdaelsipvreeargnlaenrt (diestrus)andths, wasnot cycling normally. - 61 `Company Sanitized. Does notcontainTSCA CBI 9H0:2D5a42y5G:avSaugbcehSrtoundiyciTonxRiactistwyithOne Generation Reproduction Evaluations DuPont11418 --~ INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS IN Py FEMALE RATS GROVE TV-0: 10 mg/kg/day NAUNMIBMEARL NUMBER OF PERCENT OF PERCENT OF PERCENT OF MEAN CYCLE PRECOITAL DACYOSLLOEFCTIDOATNA DAYS IN ESTRUS DAYS IN DIESTRUS DAYS IN PROESTRUS LENGTH (days) INTERVAL (days) 666655128102 665292 2225 3288 s7a6s8 156%8 22 23% Gay 18 44.0205 400 25 2 666655210857 22a1 22588 74558% 20IX%) a4l0o0o 31 666655221603 * 2213 3178% 72088% a13e 4.al0o0o 11 666655214881 * 225 665293 21 32888% 524%3 33 528 80%% ae 4.al0o0o ale 52 1 666655239209 2264 3385%% S2888 aas 665253 23 22% 78 as 440000 00 36 3 666655228816 665186 2233 3256%% 6557%8 5ot 23 358 528 13% 4410205 200 33 3 ~~ 666655239340 665240 2232 a2s3e8 5E2Y8 058% 21 29% 718 08 42210205 4150 23 1 665258 26 EN EN os 5.00 5 ~~ "Noceovpiudleantcieonofwcaospauslsuamteidwoatsonbefotuhnedabsutteasltirtuesrdwraisngdecloihvaebriedt.atiTono;ctahlecualyatse otfhpeerPsreicsotietnatldIinetsetrrvuasl,thtehtedfaoylloofwed `were excluded from calculations since the animalwaspregoant (diestrus) and thus,wasnot cycling normally. _-- Te- Company Sanitized. Doesnot contain TSCA CBI 9205.4Da2y5G;avSaugbeeShtvoundiyciTnoRxaitcistwyithOne-GenerationReproduction Evaluations DuPont-11418 --~ INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS IN By FEMALE RATS SE NANODMIBAELR GROUP VI-0: 100 mg/kg/day --PERCENT PERCA ENT -------- DANYUSMBOEFR DOAFTA OF DAYS IN OF DAYS IN PERCENT OF DAYS IN MELAENNCGYTCHLE PIRNETCEORIVTAALL COLLECTION ESTRUS DIESTRUS PROESTRUS (days) (aays) 666655323189 565267 223 3380%8 7a08 22 27% ean 00%% 58 44.l0000 3.25 33 2 665565332351 665217 2252 32688% 65584% a5% 21 19% 71% 108 41.0000 00 25 1 se66s5226227 665247 2252 24 32638% s6aat8 L0a8s 33% 67% 08 i5e0r0 100 52 a 666655321423 2232 330288 s5a2t8 75%8 3l0400 32 566655220078 * 2231 565273 21 23238% 65218 117%% 5.0000 20% 578 19% 5.00 11 1 566655227724 565195 2221 a318s% aasset 112088 2 16% 508 a 4ll0000 al00 21 a ~~ 666655331146 665173 3221 3114%% 7E1l8 a5%8 2 6s sen 08 a3l8e3 112 aloo 4 --_ eerrs----p-- * Evidenceofcopulatiwoasn found, but animal did not deliver iter 6 Company Sanitized. DoesnotconTtSaCAiCBnI 9H02-5D4a2y5G:avSaugbeehSotnuidcy iTnoxRiactistywith One-Generation Reproduction Evaluations DuPont 11418 --~ INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS IN Py, FEMALE RATS GROUP VITI-0: 1000 mg/kg/day AANOIMBMEARL. NUMBER OF PERCENT OF PERCENT OF PERCENT OF MEAN CYCLE PRECOITAL DCAOYLSLEOCFTIDOATNA_DEASYTSRUISN DDIAEYSSTRIUNS PRDOAYSSSTRIUNS L(EdNayGsT)H INTERVAL (days) 666655129936 * 22 231388 751483 1BE3)% 45.3030 3a 666655331250 2231 3286%8 855%% 1P2y8 44..0607 13 666655237198 222 1280%% s54a3s 11878% i4.e00 23 6s6e5s225244 2211 L24a8s 771%8 195%% 54.0000 11 666655234252 2231 3199%% 5221% 199%% 440000 31 666655231241 22a2 2a32% 658080 98%% 42050 a2 66g655127651 2214 1353%8 s682%8 198%% aallss7 41 66g655116991 226 3155% 753788 1258% a2l5o 53 --_ 66g655225315 2214 2254%% 7368 103%8 aPRlo 41 665213 22 23% san 148 00 2 665280 * 2 25% EO 8s 2.50 5 *No`ecvoipudleantcieonowfcaospauslsatuimoendtwoabsefotuhnedlbatuteastlriutserduwraisngdecloivhearbeidt.atiTooncthae dlaycsotfuhpelPrrseaicsottietnaetl dIinestterrusvtathlhat,fdoalyloowfed ~ Evi`dweenreceexocfcloupdueldfatrioomncawlacsulfoautnido,nbsuincaenithmaladnidmanlotdwaes lpreiganvainetterr(.diestrus) an thus,wasnotcycling normally. 126 CompanySanitized. Does notcontTSaCAiCnBI 0H:-2D5a42y5G:avSaugbcehSvtoundiyc iTnonRiactistywith One-Generation Reproduction Evaluations --~ DuPone-11418 APPENDIX DD INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES IN P; FEMALE RATS -- 1265 `Company Sanitized. Does not contain TSCA CBI 9Ba0sDianys:GoSuvbsSotnuidcy TinoRxiactistywith OeGenerntion Reproduction valutions Dupone11618 ~ INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES IN Py FEMALE RATS EXPLANATORY NOTES Notes TestDays 74:88 = Cohabitation period Abbreviations D = Diestrus PE == EPrsoessis X= Nosample or stage could notbedefined from sample. --~ PN -------------- Company Sanitzed. Doss not contain TSCA CBI ~2 Z z a 3 z g4 a3 J 8s LE Hog #3 i 8 EE 22 i= 8i gq | 25 EE] 55 2 i ~ 2a3g BTR TTT Bllel RTT lle RTT Ler elTTTTTT ELL elTTTTTTITITETTT el eTe TTTTl TTTR El el BT TTeT T ERR TTT de TT Bla a TTT ITT] EENCNCENANRNRNNND-NEN liaal TTeT l Ele eB TTLTE] elfeeelal [TB Hel ellaleme BaERREE ERE EReleledele [<1 - EE-RE - ER | lee slalelel slelalalas] Eleleplalelafieelalalaialalalale] meme EM BE 8 -F-BE-8 Ele ellaae Fle Riel] ElelElElalElalalellaalla alelalsla| elo! EE] joo RR) El aE EE (ele laelelelelafe ole]Bi -l|o G ElelelalalolalaleEllaleall@alslalola] eloEE | ole lele) [2 i = =RRR - = ElofelelelelaleBalolalcBalolo|- BE Blalalelelelololafalolole Rolalo go] (0c8-EE - FE -CE~ - -| i ~ = ~~ I22E2AE8 RseielEsieele deelsiaieiele Sells) 2 i i: 3 3% 532 iz 23 2| 3 HE if 1 3 $2 22 --- = 2 5 3 a 3 i3 g3 --- ga Jd 8. i 53 LI HE gE gz Ego: g3 2% 28 2 3 23 28 Be TTT EL ae TI L de Te E ER OO ELT al felTTT Eee HA ERO HT BULR TT R RU Ia TT oL RTTTTTTT] lee TTA EE ll Ela]T To El LpTe A] WS CEEREREERE8 E 8-8 REE ERR oe ee ole Sleelle ElafallsialalalsliaE l]aa [ooo El = = EeRellc=l BER Elaele eel ela E laa aR =a lalsfa|clo sla | (SEES -|- - HEEE- DEEEEEEE CRER==[SRCARE Elma alele] ; Elo EE ~ el : BleleloElel le ole lolalolalslole] (Elelalalefelelolale Ba Elo EH-lo] RR= ol |= i = ol EE le Bllalo ole EelBol|olo[- lo (Flelalo} GO oe] zlelsiglglelgeleisislsiclaislelsieleisls % 8 3 3 i 5 2 i 3 5 3 & 5 Zz i ECHENNNNNNNEANNNNNNNNRNNRNNNNNRNNNANCNN e ERENNNNNRNe NNRNNNNNCN ECHCNC NNNNRNNRNE NNNANNAC : E ELBE E E T 3i SL6[EETeEETTE Eee [FEE[|J % EERE I 2: Ferme lp EEE di f1s% || cEEpmRiEmEEEEmEc REE f: LI RoE { 4 EERE | gi:: Cie BolCcl :i HgI EEllem fr WR Eo :i rik3 I ol-lI loe 1: (lll ; 1i 5E6l-l60e-08ol8RE-8oc| :: %& lcleofonl hnteslefefosenlesfalesfo fosofhe J :3 2 3 i3: Pa) -~ 83 gs H1I iE [ER 4H5I 2 oF Jf3 gH3si 3 BEEEE RTE E BlEe TTTTTH EEENoCANNNCNAANNNNNAANRRNNNNAARARNNNNNGD) EEREEET TT e T ESREE RENE C NNARNE ERNNC) EREFETH TCE TEE T] (F Eola[ eS eEE eE S olol Ee EE Bees) [oR RERa EE ElEe e Re ECCmEmemSEREE EE EERE [REl=lo SeoIe loBlooel lEelec = oleol eT EREEoEB--GREp --El- h -FloAll f[loloJleolloil=o oi clo- Selo coe ec 52/821521818 SEIR ESEB 2188S8 8) ii |)3Hi (i1s: Hi: ii:H 2: Zz 'H9205-4Da2y5G;avSaugbcehSrtoundiyc iTnoxRiactistywithOne-Generation Reproduction Evaluations ~~ DuPont-11418 -- APPENDIX EE INDIVIDUAL MATING DATA AND GESTATION LENGTH: P; GENERATION -- --@ `Company Sanitized. Doss not contain TSCA CBI 2903-0D2a5y:GovSaugbeehSvtoundiyc iTnoxRiactistywithOneGeneration Reproduction Evaluations Dupont 11418 ~~ INDIVIDUAL MATING DATA AND GESTATION LENGTH: P; GENERATION EXPLANATORY NOTES Abbreviation ~ = NoDaa ~~ -- -- `Company Sanitized. Does not contain TSCA CBI 9H-02-5D4a2y5;GavSaugbeehSrtoundiyciTnonRiaciistywith OneGeneration Reproduction Evalustons ~ INDIVIDUAL MATING DATA AND GESTATION LENGTH: 7) GENERATION GROUPS: II-0,1-0 DOSE: 0 MG/KG/DAY DuPont11418 FAEDOOLLES sseess323240 6e5527557 sg6es1s92 seGe62ss233i0261 Sseessz268a9 SSeessi0a6s SS6ess0;6 SS6esia0s8 ss6ee5ss2z20s03a0 MANMIsMAL#S1 ecsesai0ss 6eeess0tuis sseesi00ss seeessss00rasst esessoorss sseess0i0s0s sseessoisz es66sa0sinss sessaeesssoo0nz8s OBSBEURGVED .: :: :: ++: +: :: :: :: :++ MNDAMEAL#A2 OBSPELRUVGED PLRIOTDTUECRED .: :: :: ::+ :: :: :: :: :++ LGEENSGTTAA(TdIaOyNs) 22 =pA. 2a n22 223 rad 22 22 222 --~ ~~ --------------r *Gestation lengthcouldnotbecalculated sinonevicdeneceofcopulation was observed. - uo ______ `Company Sanilized. Does notcontainTSCA CBI H9:02-5D4a2y5:GavSaugbesSotnuidcyiTnoRxaitcistwyithOne-Generation Reproduction Evaluations ~ DHDIVIDUAL MATING DATA AND GESTATION LENGTH: ; GENERATION GROUPS: 1V-0,111-0 DOSE: 10 MG/KG/DAY Dupont-11418 FANEDOOILES ssseeesss22i19s220 s6e6ssi1e0r5 e6e6s5216130 ssesszien 6e5s219239 6G5e2s9503 sge6ss22e0n6 sseee5ss1i3s40e sSeess2z4sae WANIEMALeSl e66s5a03s7 sseessioeosl sseessiizzse seessoior sseeassosx7 sseesoiar sgeessoisnes cseessoosrss 6s6e3s000s6s gseessotne0 OBSBEURSVED :. :: :: :: :: :+ :: :: :: :: MANNIMEALS? OBSPEIRGVED PLRIOTNTCEERD .: :: :: +: :: +: ++ :: :: :` LGEENSGTTA(TdIaOyNs) 2zn 220 2Za 2Za 223 22 32 3FH 22 F2l --~ --_ tse ------ *Gestation length could not be calculatedsince noevidenceofcopultionwasobserved. TT &- ---- `Company Sanitized. Doesnotcontain TSCA C81 02-5D4a2y5:GavSaubgeehSrtoundiyciTnoxRiactistwyith One-Generation Reproduction Evaluations ~ INDIVIDUAL MATING DATA AND GESTATION LENGTH: By GENERATION GROUPS: VI-0,-0 DOSE: 100 MG/KG/DAY DuPont. 11418 AFNEDOSuLES ses6e5ss21s69e7 6655333215 sseess222117 sseessz2s72 es6ss12423 g6e5s220978 sseessz277a3 sseess2i7s2s egess3iis6 65173 wAoNmDALS eessoinss csaessoosst sseessn0a7a8 ees5o0s3 sseessoo0sde sseessiiaioe essesesssioasans cceessoosnss 6s3e0so0s3s ses OBSPEORGVED :++ :: : :: :: :: ::+ +` :: : wAMNDEOLRY OBSBEoRoVED RLODiKtED ++ :: :: :. :: :: :+: :: :: : LeEsNmGaTHn(idoanys) 22 22 223 22 22 2= 2223 22 23 2 --_ --_ EE `CompanySanitized. Does notcontTSaCAiCnBI H-25425; Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ~~ INDIVIDUAL MATING DATA AND GESTATION LENGTH: Py GENERATION GROUPS: VIII-0,VII-0 DOSE: 1000 MG/KG/DAY Dupont 11418 AFNEIMMMAEL 6655219953 e66s5a32s0 ssseeesssza22l7as9 se6e5ss3zi2ss2a ssss2a1;0 ssesszi6s eSesstieosn s6e5s225351 6G65s221830 AWNADSOL1S ssees0s50 egsessa00zs2 sesesesssii0eszl ecseasss sseess0isz9 eessssoolsss eessosose0s seessosoy sseesiisosss 665077 OBSBEURSVED ::: ::: :: :: i: +: :: :: : MAANEDAL#Y2 OBSFEURGVED PLROuDCmED +. :: ::: :: 3: :+: :: :: ++ GLEENSOTTAHT(IdOayNs) 2oe 2Ze 222 2F3H 22 225 2FH 22 2=. ~~ --_~ ---- * Gestation length couldnotbecalculatedsince no evidenceofcopulationwasobserved. ite Company Sanitized. Does not contain TSCA CBI H9:02-5D4a2y5G:avSaugbcehSrtoundiyeiTnorRiacsitwyith OneGeneration ReproductionEvaluations --~ DuPont 11418 APPENDIX FF INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY: Py GENERATION FS `Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats withOne Generation Reproduction Evaluations DuPont-11418 ~ INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY: Py GENERATION EXPLANATORY NOTES Abbreviations NP = Not Pregnant -- = NoDaa --~ --_~ 17s `Company Sanitized.Doesnot contain TSCA CBI 1.25425; Subchvonic Toxicity 90-Day Gavage Study in Rats withOneGeneration Reproduction valuations DuPont 11418 ~ INDIVIDUAL THPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY: Py GENERATION GROUPS: II-0 DOSE: 0 MG/KG/DAY ANnuimmbaelr SAtnaitmuasl BPourpns ImNpulnabnetratoifon sites plantation Eciciency 665220 1s 16 93.8 665334 1 I 82.4 665257 5 5 66.7 665175 12 12 100.0 665336 15 16 93.8 665192 1 1 100.0 665232 3 15 86.7 665307 1 16 87.5 665246 13 1 52.9 665289 3 -- -- we 665264 10 1 7.4 665185 13 1 52.9 665206 16 16 100.0 665306 15 16 93.8 665226 1 15 86.7 665198 16 18 88.9 ~~ 665249 15 16 93.8 665280 1 16 87.5 665240 13 13 100.0 665203 3 3 100.0 -- me CompanySanitized. DoesnotcontTSaCAiCBnI H25425: Subchyonic Toxicity 90-DayGavageStudyinRats withOneGenerationRproduction Evaluations Dupont-11418 --~ INDIVIDUAL IMPLANTATION SITS DATA AND IMPLANTATION EFFICIENCY: Py GENERATION GROUPS: IV-0 DOSE: 10 MG/KG/DAY Nanutmrbaelr SAtnaitmuasl PBuoprsn ImHpulmabnetratoifon sites pBlEafnitciaetnicoyn 665212 12 13 52.3 665180 1 15 93.3 665292 3 7 a2. 665187 1 16 87.5 665205 5 15 60.0 665263 16 18 88.9 665210 12 13 92.3 665161 13 1 92.9 665208 [ 15 25.0 665293 13 16 81.3 665329 15 15 86.7 665290 1 18 77.8 665253 10 90.0 665286 16 15 100.0 665281 12 19 63.2 665186 12 1 85.7 ~~ 665330 1 16 87.5 665290 14 IY 82.4 665244 7 2 100.0 665258 13 15 86.7 --~ we `CompanySanitized. Donotecontsain TSCA CBI H25425: SubchronicToxicity 90-Day Gavage Study in Rals with One-Generation Reproduction Evaluations DuPont 11418 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY: Py GENERATION GROUPS: VI-0 DOSE: 100 MG/KG/DAY ANnuimmbaelr SAtnaitmuasl Buoprsn ImpNluamnbetratoifon sites Ioplantation Eficiency 665338 18 19 94.7 665219 5 5 100.0 665267 10 16 62.5 665325 12 1a 85.7 665331 1 1 100.0 665217 17 n 100.0 665227 3 15 86.7 665262 5 5 100.0 665247 13 16 81.3 665243 10 13 76.9 665312 12 13 92.3 665298 we - -- -- 665207 1 16 87.5 665273 7 3 77.8 665270 1 1 100.0 665272 1 5 84.6 --_ 665195 15 18 83.3 665314 15 16 93.8 565316 15 16 93.8 665173 1 IY 100.0 --~ CompanySanitized.Does notconTtSaCAiCnBI 1.25425; Subchonic Tosicity 90-DayGavage Study in Rats withOneGeneration Reproduction Evaluations DuPont 11418 --~ INDIVIDUAL IMPLANTATION SITE DATA AND TMPLANTATION EFFICIENCY: P, GENERATION GROUPS: VIII-0 DOSE: 1000 MG/KG/DAY Nanuimmbaelr SAtnaitmuasl BPoupms ImNpulmabnetratoifon sites IBmepEliacniteantciyon 665296 13 13 100.0 665193 15 16 93.8 665320 15 15 100.0 665315 12 12 100.0 665318 18 18 100.0 665279 18 20 50.0 665220 ne -- = --- 665254 15 16 53.8 665245 12 1 85.7 665322 1 13 84.6 665214 3 13 100.0 665321 15 15 100.0 665171 5 12 50.0 665265 16 16 100.0 665169 15 15 100.0 665191 1 1 100.0 --_ 665231 1 15 93.3 565255 1 1 89.5 665213 16 19 84.2 665280 ft 18 94.4 Te CompanySanitized. Does not contain TSCA CBI H-25425: Subckronic Toxicity 90-DayGavageStdyinRas with One-Generation Reproduction Evaluations --_ Dupont 11418 --_ APPENDIX GG INDIVIDUAL PUP SURVIVAL: F; GENERATION Ts `Company Sanitized. Does not contain TSCA CBI 5205D4a2y5:GavSaugbcehSrtoundiyc iTnoxRiactistywithOne GenerationReproduction Evaluations r~ INDIVIDUAL PUP SURVIVAL: F; GENERATION EXPLANATORY NOTES Abbreviations N- P = = NotPregnant Nobama Dupont 11418 --_ --_ Tim Company Sanitized. Does not contain TSCA C81 'H9205-4D2a5y;:GavSaugbcehSrtoundiyc iTnonRiactistywith One-Generation Reproduction Evaluations Dupont11418 ~ DIDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: II-0 DOSE: 0 MG/KG/DAY aWMnBEaR BowY sseess23230 11 se86s3z1s775 2` ss6ess139326 11 5s665s320372 F1e sseess226a9s (wp) 3 sesessz16es4 3 886633320088 156 s8e6s3212968 i5s Ssssssa2d4s i1s sSeessz24003 133 Mouse OF PPS ABOLRNE BREDCAUYLLI4NG RODSTACYU4LLING BAYT u5` 115s 550 55` 2is 1bf 88 88 Iun be1] 65 5s 11 13 s5 55 - 0i Ft] 88- 78: 116s iiss 8 85 116 11 5s 88 11 115 3 fi} .8 s8e i5 8 s DAY Ia DAY 21 555 85c 85 5e 8 s5 s8 85 7-e 75- 5s s5 s5 88 5o5 ee s e PS -- 1285 Company Sanilized.DossnotcontTSaCAiCnBI 2H002-:5DD4aa2yy5GG:aavvSaauggbeceShSrutodundiyyciTinnoRxRaiatctsistwywiitthhOOnnGeeeGneenrearattiioonnRReepprroodduuccttiioonnBEvvaalluuattiioonnss -- INDIVIDUAL FUP SURVIVAL: FIA GENERATION GROUP: 11-0 DOSE: 0 MG/KG/DAY DDuuPpoonntt1114141188 aWBmGoERs BRN sess6s232300 75 s8e6s5127557 52 ss8e66s5s123533226 55 5 segsssz3a0s7 $5 cseesszzs6e6 mm ` s86e5s2i0s6s 5c essess320286 05 sseessi2s0e 10s s8e6a32s40 s` 865203 5 NOMBER OF MALE PUPS BALOIRVNE PREDCUALLI4NG ROSDTACWUALLING DAT 27o 25 2 32 24a s8 55 hi HI s5 c a5 ` 3h3 33 i 5o- 5: a: h: 85 5c h3 3a 108 105 fr} 10 a5 a hi5 55 s s` : hh i 33 a 5 3 5 5 Da ld mara ha .3 2h 3 2aa ia 3a hh 3i i- -a 4i h3 53 a5 aa 3i a:3 33 3 3 -- Pa -_-- 186 CompanySanitized. DossnotconTtSaCAiCanl H:25425: Subchronic Toricity 90-Day Gavage Stay in Rats with One-Generation Reproduction Evaluations DuPont-11418 ~ INDIVIDUAL PUP SURVIVAL: PI GENERMTION GROUP: II-0 DOSE: 0 MG/KG/DAY nNammeER BOW s68836655322325407 5. a asGessiasse 7` sseess129322 5e 8Gd66e35s322084756 (we) 55 - sseessziesas 3a 468365320088 17 asgasssss122942856 735 seGssz2a804 55 865203 10 MBER OF FEMALE PUPS ABOLRNE BREDCAUYLL4ING P0DSATYCULLING DAT 55 55 aa 43 sa 33 ha 33 75 25 33 aa 58 s oe 5 333 hs3 a- i- h- 3- 107 02 33 3a 375 73 ` 13a 3i5 75 78 4a 33 105 105 35 a5 Dale Dara ia i h4 ha 43 hh aa` 31a i- - 33 33 :33 ii5 `3 hh 35 35 --~ --_ 287 CompanySanitized. Doesnotcontain TSCA CBI 9H02.5D4a2y5G;avSaugbechSrtoudiyciTnoRxaitcsitywith OneGenerationReproduction Evaluations DuPont-11418 ~~ INDIVIDUAL PUP SURVIVAL: FIA GENERATION GRO---UP: T3-0 DOSE: O MG/KG/DAY wousER OF FURS, onmeen SEX RATIO (MALES) BORN ALIVE 0-4 DAY VIRILITY rac`TTaoTEIxon gs66ss232304 s6s287 00's.47 0.33 110000..00 100.0 110000..00 10010 110000.000 10000 ole 1000 10010 100'0 Sse6ssi137s5 sseess213522 003583 038 11000000 100.0 105012005 10000 110000..00 100.0 s8e6s323i0s7 ces289 vB) olo-lsa 1100001000 - 110000-0000 01000-.00 Ssseeesssi2za60s46 Gs308 00o.1l63e08 10100.00 10000 101000..00 100.0 1070.50 1000 0's 1000 000 1000 EG5s129286 S65245 0o.6m3 0ls3 110000.00 1000 11000000 10010 1100001100 0010 Gg66s5228440 g65203 0o:a38 023 110000.00 10000 101000170 0 10000 110000000 10000 --~ -- - Tiss CompanySanitized. Does notcontTSaCAiCnBI 9F0-.2D54a2y5G;aSvuabgcehSrtoundiyciTnoxRiactistwyithOne-GenerationReproduction Evaluations ~ INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: I1-0 DOSE: 0 MG/KG/DAY aomsea ss6ess232304 ss6ess127557 sesses139326 sGe6s5233027 Ga6e5s2a8d9e (wp) Sseess12065a 886633320068 Ss6ess21286 sSeess22a8s0 5se6s5228003 BORN ALIVE 1010001.00 1100001100 1100001000 1100000000 01000-0.00 110000..00 111000000...000 110000.00 11000000 NUMBER OF YALE PUPS 0-4 DAY VIBTLITY 110000..00 120007000 150000000 1020000100 110000-.700 10000000 101000.000 110000.00 1100000000 10000 LAC`TTiAwTeIxON 110000..00 1100001100 1100007.00 1100001000 110000-..00 110000.00 11000000 110000.00 111000000011000 ~~ Dupont 11418 ~~ - 12 Company Sanitized. Doesnotcontain TSCA CBI 'H9-02-5D4a2y5;GavSaugbcehSrtoundiycTionxRiactistywithOne-Generation Reproduction Evaluations ~ DDIVIDUAL FUP SURVIVAL: FIA GENERATION eGROUeP: T1-0 DOSE: O MG/KG/DAY MBER OF FEMALE PUPS Seneors 4 BORN ALIVE 0-4 DAY VIABILITY Lac`TTaeTxION 886655323240 863257 110000.000 10070 110000%.00 100%0 110000.0 100.0 se8s63313765 sesis2 1100007700 10010 1010000%0 10000 110000..00 100.0 assseesssa23d30e27 111000000.000 101000..00 20000 Ses28s (ue) - 2 110000.00 100:10 GGeess1a8e5 865206 110000..00 100.0 110000.000 1000 10705.100 100.0 ssse6es3s231209688 101100000.1.000 1100000000 10000 110000.%00 100.0 sesses22s4a9 ses240 1100007100 10070 1100000000 10000 110000.00 1000 665203 1000 10070 1000 --_~ DuPont-11418 --~ - T1290 `CompanySanitized.DoesnotcontTSaCAiCnBI 9F0-2D54y25G;avSaugbecShrtourdiyciTnoRxaitcistwyithOne-GenerationReproduction Evaluations DuPont 11418 ~ INDIVIDUAL PUP SURVIVAL: FIA GENERATION e Gowm: 10-0 DOSE: 10 MG/KG/DAY NuMBER OF UPS aPmomemne sow ABOcRiNe BREDCUALLI4NG POSDTACYULLING D7 DA Daal seGs65z110z0 12 665292 3 123 112 3 e 3 ss 3 88 3 85 3 S86635128075 101 s6s263 is us 55 1 16 66210 1 12 1 88 55 8 8 58 55 53 s5 sseessziesnl be]3 Gs293 1 io ko33 25 5 :5 5 5: 5 8 8 86655322990 13 863253 5 13 11o 55 5 55e 85 8 8: s Sseesa2m86 sesise 116 1 126 2 116 12 56330 pr ie prt e8 8 e` 5e 55 55 558 e SS552240 17 Ses2s8 3 1H 3 117 78 8 75 5 H8 8 78 : --~ --_ - Te `Company Sanitized. Does not contain TSCA Cal 9205.4D2ay5:GavSaubgcehSrtoundiyc iTnoxRiactistywith OneGeneration Reproduction Evaluations DuPont 11418 ~ TDIVOUAL FUP SURVIVAL: FIA GENERATION eGROUm P: TV-0 DOSE: 10 MG/KG/DAY MBER OF MALE FURS mTomoek momy BAOuRNm SREDCUALLI4NG 20DSTC4ULLING DAT DACI4 DAT2Y sss65a118z0 S65292 1052 S63187 7 55 72 es 2 aa h2 ia a2 aa 32 24a a 856633226035 se210 3 ` sesist 5 5s 55 5` 55 I3 hh I3 sh 33 33 33 h3 sSeess2z9a3s `2 Ses320 5 205 2-3 2:" 2:` 2: a 2` i 886655229503 ses286 5a 5 ses281 5 h5 55 .` 5o ii aa aa aa aa 31 33: 4 sseess3i3s0e ses294 5` H5 n ft `5 1 Ges2a 3 3 3 hs 35 3a 53 33 53 3i 35 Ses25e 6 5 1 : 4 a --~ --_ -_ Ti92Company Sanitized. Donotecontsain TSCA CBI 9H02.5D4s2y5G;aSvuabgchSvtoundiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPont-11418 ? INDIVIDUAL PUP SURVIVAL: FLA GENERATION eGReOUP: 10-0 DOSE: 10 WO/KG/DAY ABER OF FEMALE PUPS MneSnRa: pow BAOeRiNv PREDCAUYLLI4NG PODSTACTUALLING DAY? DAY IL DAY 21 sesses211820 ses292 aa 1 `a 71 4` 17 3s 31 P ia a. a1 34 a3 ag66s5210857 Ses263 5i 5 sss210 s .5 5 ss5 hi h ii : 33 3 ii i Sesion sss208 so hi- ses293 n n -a 1 -i 5 .i 5 3` -i 5 sesse2s33209 565253 5 5 `8 55 85 85 a3 33 33 33 3i 4i 33 33 ssesss228816 aesise 75 7 865330 5 77 5 77 hh 3 aa 1: aa 3 ai i ps6r2e9m0 seszse :5 a 33 `3 7 ki h3: "3 i 33 3 a3 3 -- ~ ------ No female pups were born; datawereexcluded from statistical anaes. -_ 9 Company Sanitized. DoesnotcontainTSCA CBI 9205.D4a2y5G:avSaugbecShtoundiyciTnoxRiactistywithOne GenerationReproduction Evaluations Dupont-11418 ~ nnBER se8s63211820 Ss86e63ss212980275 sesses226130 seSs65i2e4n8 8G866655s223992030 s56e5s225835 sseessi28ss1 as8565323904 SSe6ss225480 INDIVIDUAL FUP SURVIVAL: FIA GENERATION eGROUeP: Tv-0 DOSE: 10 MG/KG/DAY sER OF PUBS SEX RATIO (AALS) o0.n67 o00.l64s10 00..5500 o1lle0s0 0o0:ll3s187s 0.0.5404 0ol4a2 00.l4138 o0.l4e3 % BORN ALIVE 105017.0 1100000000 10500.00 1100000..'000 1110000001000 1010000700 110000%% 1010000.00 110000.00 0-4 DAY VIABILITY 110000.000 150200090 110000.00 1100z0000 1100100000.1000 1100000000 1100000000 1100000.00 101000..00 ac`TTATEIxON 1100001.00 1100010000 1100000000 01000:1.00 111000000..000 11000000 11000000 1100002100 1100007000 --~ ~~ - T294CompanySanitized. Doesnot contain TSCA Cal 0H:-2D54a2y5:GavSaugbcehSrtoundiycTionxiRcaittsywith One-Generation Reproducion Evaluations ~ suEnEsR sesses211620 Ss65521972 sGS666s55222160038 sseess2i4s81 sse6ss239230 sGeess225930 saessesssizzssees Ggs6ss323900 8G663s225484 --~ INDIVIDUAL PUP SURVIVAL: F1A GENERATION e GRoum p: 10-0 DOSE: 10 MG/KG/DAY NUMBER OF ALE PUPS BomN ALIVE 0-8 DAY VIABILITY LacTTEaTxION 51000..00 10070 1010007.00 10070 11100000000.000 1100000000 10000 10805007 1000 110000..00 100.0 110000.00 0.0 11000000 1100020.00 1100007000 10070 1010000.00 10070 1100001.00 10000 1100007000 10010 1010007700 100% 11100000000%000 11000000 10010 10100.000 10%0 110000% 100.0 110000100 1100000000 110000..00 DuPont 11418 -- - Tis `Company Sanitzed. Doesnotcontain TSCA CBI 9F-02-5D4a2y5G:evSaugbechSotnuidcy iTnoxRiactistywithOne Generation Reproduction Evaluations Dupont-11418 ~ INDIVIDUAL FUP SURVIVAL: F1A GENERATION = GROVE: Iv-0 - DOSE: 10 MG/KG/DAY NUNBER OF FEMALE PUPS oansoes. seSses211s20 sSe6s12897 s86e5s220653 sseess2i1s0t sesses229438 sseessses23z925093 sseesszzses GG6e5s3i3s0e sS6s52249d4 assase BORN ALIVE 1100001.00 01000.00 108037103 11000100 0 100-.0 111000000...000 101000..00 101000..00 11000000 1000 0-d DAY VIABILITY 1100001.00 1100000000 11000000 1100000%0 100-.0 110000.00 110000.00 1100000000 10100100% 1100000000 LACTTEATxION 110000..00 110000.00 110000100 1100001000 10-0.0 1100000000 1100000700 110000..00 110000..00 110000..00 --_ --_ _-- 12% CompanySanitzed. Does notcontTSaCAiCBnI 9H025D4a2y5;G.avSaubgcehSrourdiyc TinoxRiactistywithOGneeneration Reproduction Evaluators DuPont-11418 ~ INDIVIDUAL FUP SURVIVAL: F1A GENERATION eGROUeP: VI-0 DOSE: 100 MG/KG/DAY rms OF PUES aMmeoann sow sesses323189 i5 SG6e5s23627s G6s331 112 1 sSeess271277 sesz62 Fin] 5 sseess224473 fFHo] see56ss52a290z87 aE) -2 1 Saeessa2m7s4 12 gaesss217925 sssae n1 is ESeess1n7e3 1Hd 3A0LMME RECBUALYLAING POSDTACYUALLING DAY7 un5 15 10 Pt] 5s s 588 1112 2116 `88 855 1: 15 31 55 5 55 5 12 - Fr1]- 85: 55: u7 u2 u1 57 8 785 11 ias 1 is 55 5 55 5 ins 1us 55 55 DA 14 DAY 21 75 75 88 58 85 5 85 5 s5 s8 55: 8a: 38 78 88 85 85 5 585 5 5 --~ --~ - Ter Company Sanitized. Does notconTtSaCAiCnBI 9H02-5D4a2y5G;aSvuabgcehSotnuidyciTnoRxaictistwyithOne-GenerationReproduction Evaluations ~ INDIVIDUAL FUP SURVIVAL: FIA GENERATION eo GROUP: UI-0 DOSE: 100 MG/KG/DAY MBER OF ALE PUPS Namhoas sow ABORwN BREDCUL4LING PODSTaCrUdLLING Dw? Dwi sassss231358 Ses267 1o 5 seas a 18 a5 s1 h5 31 7 1a +7 31 i ssesss323117 s65221 1057 557 5` 7 hh4 aa a ii i 8ga66e53s222446372 5a s 5a h 5a 4 :a h hh h 33 h sSeeas2n98 865207 om) -55 s6s273 5 555 :8 55 :h 35 3: 55 s: 53 ssseeesssi22s17s21 e` 5 5` 5 555 +a 4 aa h 3a 3 sSeessaaea 107 868173 1 107 3 05 1 ha Bi ha 4 h4 H ~~ DuPont-11418 aa 41 7a ia ai 33 3: 53 ai s3 s3 PS -_ Ti Company Sanitized. Donotecontsain TSCA CBI 0H--2D54a2y5:GavSaugbcehSrtoundiyc iTnoxRiactistywithOneGeneration Reproduction Evaluations Dupont-11418 ~ INDIVIDUAL FUP SURVIVAL: FIA GENERATION e RoEm: VI-0 DOSE: 100 YG/KG/DAY NUMBER OF FEGLE PUPS TamBeE som ABOuRNm PREDCUALYL4ING PODSATYCUL4LING DAY 7 DAYI4 DRY 21 asSaseess322361875 04 1 Ses125 8 s3 51 5a `i 4a h1 aa ai i3 31 i5 a1 sseess323117 .7 s8e65s2z2672 51 57 53 52 15 3s :1 33 3i 33 31 :3 31 ssSeeesss22a40137z 57 hi Ges298 op) - 7c -` 5a -3 hH :a 3i :` i4 :i Hi `i 866655227037 25 sSe6ss227722 55 25 58 25 5e 25 :a 25 4a 25 3a 25 ai seSGesesss1s5 555 ses173 a 5s5 a 5` a hh3 : 331 H hs3 i 333 h --_ --~ - Ti%Company Sanitized. Doesnotcontain TSCA CBI 9H02-5D4a2y5;GavSaugbcehSrtourdiycTionxRiactistywith OneGeneration Reproducion Evaluations DuPont 11418 ~~ TDIVIDUAL PUP SURVIVAL: FIA GENBRATION eee GROUP: VI-0 DOSE: 100 MG/KG/e DAY ee. mER OF PUBS. waoBmER SEX RATIO GAMES) BORN ALIVE 0-4 DAY VIABILITY LACETAETION sseess2a1398 ses267 00..2400 0.50 105040.04 100%0 1010001.00 10010 1070..50 100.0 se56s533235 ses217 00..4333 0.5 1100000000 5411 1100007000 10000 0000..00 1000 sseess226z27 S65247 0ol.s80 ols 1100000000 10010 1100000000 10070 10000100 10070 asGs63s2i4z3 oollee0 g65298 ve) - 110000000 - 010000000 - 110000000 - S86655227037 E6274 00.7316 0.43 101000.000 10000 110000..00 100.0 110000..00 100.0 gs663s129752 S634 o05lse ola 1100007%0 10000 110000..00 1000 110000..00 100.0 sSe6s13753 0o7l6s 11000000 10100.000 01000'00 ~ --~ - 00Company Sanitized. Doesnot conTtSaCAiCBnI 9H02-5D4a2y5:GavSaubgcehSrtoundiyc iTnoxRiaciistywithOneGeneration Reproduction Evaluations r~ INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY -- NUMBER OF ALE PUPS anmeEs aassss231398 asgsss236275 sseess231371 sesses226227 sseessses23241a723 sS6e5s220070 (we) 66655227743 886655129752 sSeess33116a s6s173 BORN ALIVE 110000.00 1010001000 1050700.0 1100007000 110010000770000 1002.0 101000000 11000000 110000700 1000 0-4 DAY VIABILITY 101000.000 11000000 11000000 11000000 110000100 10-00 1100000.00 1010000000 1100007000 1010000700 LacDTwaETxION 110000.00 1100001100 111000010000000 110000000 0000000 100-.0 1100000000 1100000000 01000l.00 00.0 --~ Dupont11418 --~ _ Tor CompanySanitized. DoesnotcontTSaCAiCnBI 501.2D54a2y5G:avSaugbeehSvuondiyc iTnoRxaictistwyithOneGenerationReproductionEvaluations ~ DIVIDUAL PUP SURVIVAL: PIA GENERATION e Groves : vi-0 DOSE: 100 MG/KG/DAY amen op PEOLE PUPS jneono Bom ALE 0-4 DAY VISITE cDmEoKn ssGseess2sa6sr7 11052000.00 11100000.000 007005.000 GGes5s323312175 G5227 111000000..000 1011000000..000 1000 10.0 121000000000 2000 pGaresseaa6]e2 111000000..000 01100000..000 111000000..:03 SSs6eesss22a00n782 aie) 110%0-..0 110000-..00 2100020.00 SesSse6s5a2ar77a32 101102200000000 111000000.7000 2120000000 GGGeesssasiitseas Gest7s 111000000.1.000 11p0r00i.n00 15.0 00 11100000.000 15000 DuPon 11418 Tha CompanySaniized. Doesnot conTtSaCAiCBnI 9H02-5D4a2y5:GavSaubgeehSrtoundiyc iTnoxRiacsitywith One-Generation Reproduction Evaluations Dupont 11418 ~~ INDIVIDUAL PUP SURVIVAL: F1A GENERATION e GROUm P: VIZI-0 DOSE: 1000 MG/KG/DAY NomER OF PUBS vMmMe sow seSessaisosn sesaz0 1i3s 1s asgess33iss 863279 118 1 sSe6s52520 om) ses245 15 seSse2s212 ses321 11 1s sseessa1e1s 16s Gse6s5119615 i1s Saeess2z3s1s Sesz13 1n16 S6s280 nw BLOiRvNe PRECDUALL4ING PODSATWCU4LLING DAYT 115 i1 14 55 5 5s 5 1n ias u un 5o 58 8 15- 512 12 :e 8 5: 5 13 11 1s 1s 58 5 55 5 16c 5` is i 55 s 55 i1e n pr1 un 55 5 85 8 1h6i 166 8a 58 DAY 14 DAY 21 55 :s 58 38 :88 s5: 55 88 55 88 55 s8 s8 88 5s s8 5e 8 55 8 ~~ - 03+ Company Sanitized. Doesnot containTSCA CBI 9H-02-5D4a2y5G:avSuabgcelSrtoundiyc iTnoxRiaciistywithOGneeneration Reproduction Evaluations DuPont11418 ~ INDIVIDUAL FUP SURVIVAL: FLA GENERATION eGROUeP: VIII-0 DOSE: 000 MG/KG/DAY NABER OF MALE PUPS Mnoomn sow BAOvRNe BREDCAULYLI4NG PODSTwCULLING DAT DAri4 Darl sseess129936 865320 78 8 78 55 7 57 a. 3: a` aa 3a 33 P ii SSe6s33185 863219 : 17 10" Ses2 ow - - - 33: 33: sh: :sa sSeess2z4ss4 85 ses32z s 5 28 85 35 `` a5 3h 5a ai 5i 3i 35 sseess231241 esi 75 5 seszes 5 s3 5 35 8 3a h 33 a 33 3 33 a SGG6eesss2113691s1 110"` piI]0i 1p0eH7 h: i hs 3h h3 Hi aa 3s ppee Ses280 52 H1 El3 ii hi ii 31 ~ - 104 Company Sanitized. Does not contain TSCA CBI 9H02.5D4a2y5:GaSvuabgcehSvtoundiyc iTnoxRitcistywithOneGeneration Reproduction Evaluations Dupont11418 ~ INDIVIDUAL FUP SURVIVAL: PLA GENERATION -- GRoupA : VIZIO DOSE: 1000 MG/KG/DAY woumem oF Fos UPS Tnoowm, som Baowme pREmCVaLLaING PODSTACWUALLIIG DWT DA DW 2L aGass5ss312299035 77s Gssa1s 7 73` : 23` : a`` a ii` i ii` i `i` : GGGeosr52ias om 10: 2: : ii: ii: :ii :`i GSSe6esssa3si2as2 103i 133 3a S6sa14 & : i 3ii i ii3 i 3ii : 5ii i SsSeeessaas6ans1 5;: sesies 5 3;:s 3;:5 333 ` 35i : 3ia : i5i i ssseeessstaaossns1 57i Sess 5 3&i 5 3:i 5 aai a iii i i:: i iii i Seszs0 5 5 5 a i i i ~ -- - Ti CompanySanitized. Doesnot conTtSaCAiCanl 9H-02.5D4a2y5G;avSaugbecShruodniyc TinoRnaictistwyithOne-GenerationReproduction Evaluations DuPont.11418 ~ DDIVIDUAL PUP SURVIVAL: PIA GENERATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY amEoEnR sessss219953 s6e63a32s0 sep86es532284 (ve) ssssss22saas ssssssa312e2 spees3t21 s85e5s216s5 886633129311 886655221335 863230 SEX RATIO (MALES) 00..5583 00.4523 o0.l5e5s 20.33 00..7637 o0ls.60 00.'5s06 ooll7a1 ol0'ess0 o0.l3a4 NamER oF FURS % BORN ALIVE 110000.000 15010.070 1s00i0a0 100-.0 11000000 10100070 0 110000.00 11000000 101000..00 10506.10 0-4 DAY VIABILITY 110000..00 10503.103 101000..00 100-.0 1100007700 1100001100 10903180 1100001100 11000000 110000.00 LACTTEATxION 1100007.00 110000.100 110000100 100-.0 210000..00 110000..00 110000..00 110000..00 111000000..0000 10.0 ~ ~ 1306 `Company Sanitized. Doesnotcontain TSCA CBI 'H9205-4Da2y5:GavSaugbeclSotnuidcy TinoxRiactistywithOne-Generation Reproduction Evaluations INDIVIDUAL FUP SURVIVAL: F1A GENERATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY mmeens sSeessaisosn 8Se6s833120 sesess23719e sesses225244 up) sseessiz2a2s sesess322114 ssseeesss1i27e61s5 sseessizs31 sseess2z1s3s Ses280 BORN ALIVE 1010001.00 1100007100 1a00s0 100-.0 1100001.00 1100001700 1010007000 1100070000 1100001100 1100s0 NOMBER OF MALE PUPS 0-4 DAY VIABILITY 110000.00 1080705 110000-.00 110000..00 11000000 110000'00 108080s0 1100000%0 1100000%0 10000 ac`TTaeTxI:ON 1100000.00 1100000000 1100<0000 1110000000.7000 110000100 11000000 11000000 110000100 110000..00 --_~ Dupont 11418 --~ T507Company Sanitized. Doesnot contTSaCAiCnBI 9H02-5D4a2y5;GavSaugbcehSrtoundiycTionxRiactistywith One-Generation Reproduction Evaluations TNDIVIDUAL UP SURVIVAL: FIA GENERATION GROUP: VIII-D DOSE: 1000 MG/KG/DAY wommoens 866655129936 8Se6s33312s0 sseess237e9 sesses22524 up) sseess23e25z sseesszs1241 sessseess121766159 ss6sss2i3s1t assess22s1s3 S6s280 NMBER OF FEALE PUPS BORN ALIVE 110000..00 10505007 10000.00 100-.0 1100070000 1100007000 111000000.0000 110000..00 1100070000 1000 0- DAY VIABILITY 1100000.00 1100000000 110000000 100~.0 11000000 11000000 11000000 11000000 110000.00 110000.00 sa`cnmeazxon 110000.100 1100001100 1100001000 100.0 11000000 11000000 11000000 11000000 11000000 110000.00 -- Dupont11418 -- 0s Company Sanitzed. DonotecontsainTSCA CBI 9F-02-5D4a2y5;GavSaulgbeehSrtourdiyciTnoxRiactistywithOneGeneration Reproduction Evaluations --~ Dupont 11418 ~~ APPENDIX HH INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F; GENERATION --~ --_-- Company Sanitzed. Does not contain TSCA CBI H-25425: Subchronic 90-Day Gavage Study TinoxRiactistywithOneGeneration Reproducion Evaluations ~ DDIVIOUAL LIPTER CLINICAL OBSERVATIONS: FIA GENERATION GROUP: 11-0 DOSE: 0 MG/KG/DAY NwDeOsL LACDTAATYION INSCTIODNENCE OBSERVATIONS 665220 NO ABVORMALITIES DETECTED 665334 NO ABNORMALITIES DETECTED 665257 NO ABNORMALITIES DETECTED 665175 NO ABNORMALITIES DETECTED 665336 NO ABNORMALITIES DEFECTED 665192 No ABNORMALITIES DEFECTED 565232 No ABNORMALITIES DEFECTED 665307 NO ABNORMALITIES DETECTED 665246 NO ABNORMALITIES DEFECTED 665264 NO ABNORMALITIES DEFECTED 665185 NO ABNORMALITIES DEFECTED 665206 NO ABNORMALITIES DETECTED ~ 665306 No ABNORMALITIES DETECTED 665226 NO ABNORMALITIES DETECTED 665198 NO ABNORMALITIES DETECTED 665209 NO ABNORMALITIES DETECTED 665284 NO ABNORMALITIES DETECTED 665240 NO ABNORMALITIES DETECTED 565203 NO ABNORMALITIES DETECTED Dupont1415 : --~ -_-- ee `Company Sanitized.DoesnotcontTSaCAiCanl 9H02.5D4a2y5:GavSaubgeehSrtoundiyc TinoxRiactistywith One-Generaion Reproduction Evaluations ~ INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F1A GENERATION GROUP: IV-D DOSE: 10 MG/KG/DAY SAEOEL LACDTAATYION INSCTIODNENCE OBSERVATIONS 665212 NO ABNORMALITIES DEFECTED 665180 NO ABNORMALITIES DETECTED 665292 NO ABNORMALITIES DEFECTED 665187 NO ABNORMALITIES DEFECTED 665205 NO ABORWALITIES DETECTED 665263 NO ABNORMALITIES DETECTED 665210 NO ABNORMALITIES DETECTED 665181 NO ABNORMALITIES DETECTED 665248 ALL PUPS BORN DERD 665293 NO ABNORMALITIES DETECTED 665329 NO ABNORMALITIES DETECTED 665290 NO ABNORMALITIES DETECTED ~~ 665253 NO ABNORMALITIES DETECTED 665286 NO ASNORMALITIES DETECTED 665281 NO ABNORMALITIES DETECTED 665186 NO ABNORMALITIES DETECTED 665330 NO ABNORMALITIES DEFECTED 665294 NO ABNORMALITIES DEFECTED 665244 NO ABNORMALITIES DEFECTED 665258 NO ABNORMALITIES DETECTED Dupont. 11418 -_-- CompanySanitized. Does not conTtSaCAiCnBI 9H-02-5D4a2y5G;avSaugleetSrtoundiyc iTnoxRiactistywithOneGenerationReproduction Evaluations ~ INDIVIDUAL LITTER CLINICAL OBSERVATIONS: PIA GENERATION GROVE: UI-G DOSE: 100 MG/KG/DAY jaonro sammy INsCiIoDnRICE OBSERVATIONS wee 665338 DAY 7 lore SWALLwoLE BoDY Lorem s;egRy: 1 SWALL WHOLE BODY 665219 NO ABNORMALITIES DETECTED 665267 NO ABNORMALITIES DETECTED 665325 NO ABVORMALITIES DETECTED 665331 NO ABNORMALITIES DETECTED 665217 NO ABNORMALITIES DETECTED 665227 NO ABNORMALITIES DETECTED 665262 NO ABNORMALITIES DETECTED 665247 NO ABNORMALITIES DETECTED 665243 NO ABNORMALITIES DETECTED 665312 NO ABVORMALITIES DETECTED ~ 665207 NO ABNORMALITIES DETECTED 665273 NO ABNORMALITIES DETECTED 665274 NO ABNORMALITIES DETECTED 665272 NO ABNORMALITIES DETECTED 665195 NO ABNORMALITIES DETECTED 665314 NO ABNORMALITIES DETECTED 665316 No ABNORMALITIES DETECTED 665173 No ABNORMALITIES DETECTED DuPon-11418 -- eee ---- I ---------- `Company Sanitized. Does not contain TSCA C81 9F-02-5D4a2y5G;avaSugbecShtroundiycTionxRiactistwyithOne GenerationReproductionEvaluations Dupont11418 ~ INDIVIDUAL LITTER CLINICAL OBSERVATIONS: FIA GENERATION GROUP: VEII-O DOSE: 1000 YG/KG/DAY SAoNmDeO LACDTaAvTION INCSIIDGNENCE OBSERVATIONS i 665296 No ABNORMALITIES DETECTED 665153 NO ABNORMALITIES DETECTED 665320 DAY 0 101s SAL WHOLE B0DY LonrER smmgmy: 1 SWALL WHOLE BODY 665315 NO ABUORMALITIES DETECTED 665318 NO ABNORMALITIES DETECTED 665279 NO ABNORMALITIES DETECTED 665254 NO ABNORMALITIES DETECTED 665245 NO ABNORMALITIES DEFECTED 665322 NO ABNORMALITIES DEFECTED 665214 NO ABNORMALITIES DETECTED 665321 NO ABNORMALITIES DETECTED ~ 665171 NO ABNORMALITIES DETECTED 665265 NO ABNORMALITIES DETECTED 665169 NO ABNORMALITIES DETECTED 665191 NO ABNORMALITIES DETECTED 665231 NO ASNORMALITIES DETECTED 665255 NO ABNORMALITIES DETECTED 565213 NO ABNORMALITIES DETECTED 665280 NO ABNORMALITIES DETECTED --~ TB Company Sanitized. Doesnotcontain TSCA CBI 9H02-5D4a2y5:GavSuabgcehrSotnuidcy iTnoxRiactistywithOne.Generation Reproduction Evaluators Dupont. 11418 APPENDIX II -- INDIVIDUAL PUP WEIGHTS: F; GENERATION -- - En CompanySanitized. Does notcontain TSCA CBI 51.02-5D4a2y5:GavSaugbcehSvoundiyc iTnorRiactistywithOne Generation Reproduction Evaluations ~ INDIVIDUAL PUP WEIGHTS: F; GENERATION EXPLANATORY NOTES Abbreviations NP = Not Pregnant Blank Spaces = No Data DuPont 11418 --~ --_--TE------ `Company Santized. Does not contain TSCA Cal 9H02D54a2y5G:avSaugbeehSruondiyciTnoRxaictistwyithOneGeneration eproducionEvaluations = INDIVIDUAL PUP WLEaIcGtHaTtSio(ngrDaamys):0 Fy GENERATION Dupont 11418 Group: 11-0 Dose: 0ma/kg/day _ Mp--R . 2 3 4 PupsNusmber 7 8 3 10 65220 8S 7c.l3a 76.51 67..65 66..66 67.53 76..07 1621 7.0 6533 & 66..80 66.17 56.34 76.61 66..20 56..88 6.4 6.2 ses2s7 665175 & 8 73..80 6.8 82.5 7.0 87..01 87..00 7.5 7.6 1.2 7.7 65336 e 76.30 sl3 76..28 68 67.82 67 61.72 63 67.53 76..56 16..74 7.1 ees192 2 77..48 88.10 76..36 76..86 78..21 7.0 6.5 7.6 7.3 65232 5 76.s8 77.05 47.88 77.8 16.25 7.4 7.4 6.7 65307 65206 & 77.060 6.7 76.70 6.9 77..31 6.7 77..98 6.3 77..15 6.9 78.a1 6.6 76..17 76..71 es289 6x0e 64 63 61 5.6 ~ Gos260 8 8o.w8 8.4 8.2 7.5 8.4 8.4 eesies e s7l.a8 63 77.30 71 67.30 65 7772 63 56.56 77.11 6.1 665206 665306 3 & &6.l85 6.5 67.10 6.9 76..16 6.8 56..85 6.0 66.07 6.0 57..32 6.0 56.83 76..01 6.6 5.8 65226 75.1 75..29 57..24 75.32 66.29 65..66 66..07 6.8 6.9 7.1 65198 8 2& 55.28 sls 65.57 5.4 66..50 5.8 56.51 65..06 55.77 5.6 6.3 6.2 61 . 65200 & 66.03 56.08 66.30 65.30 56.72 55..86 56.18 6.5 ees284 7.0 7.3 7.4 6.7 6.9 1.1 : es200 8@ 5 76.71 64 6s.i5 70 66.94 5.8 67..91 66 76.52 1.2 63 7.0 6.8 66 6.0 6.5 665203 &$677.5 66:48 16..14 5.0 68 67 5.2 63 6.6 6.0 ~~ T16Company Saniized. Does not contain TSCA CBI 9H-02.5D4a2y5:GaSvuabgcehvSourdiyc TinoxRiactitywithOneGeneration Reproduction Evaluations DuPont-11418 ~~ INDIVIDUAL PUP WLEIaGcHTtSa(tgDriaamoysn0): Fy GENERATION Growp: 1-0 Dose: 10 mg/kg/day MAiniemarl SPuep 1 2 3 a B5spSu6gar18 9 10 1 65212 & 77..86 67..29 77..36 81..20 7.6 1.5 7.5 1.8 665180 & 7.0 65 7.1 6.8 6.5 6.6 1.8 6.5 6.8 7.1 6.6 6.3 e522 & 89.50 8.2 665187 ? s5l.s9 67.12 66..44 66.33 66..26 66..31 6.2 6.1 665205 28 78.06 67..43 71.16 67 1.4 7.2 665263 & 87..53 86..94 6.7 7.3 7.6 7.8 8.1 7.4 7.2 7.2 7.8 6.9 7.6 5.9 665210 ? 66.58 65..54 66..14 65.32 66..15 6.6 6.2 65181 ?& 76.65 66.16 76.16 6.7 61 7.3 1.3 7.2 1.7 6.60 665248 &2 NNoo LLiivvee PPuuppss ~ 665203 8 77..18 17..65 7.3 7.1 7.0 7.1 7.6 7.0 6.80 7.10 7.30 65329 & 7.9 7.6 8.0 6.4 7.9 7.7 7.6 7.7 7.5 7.4 7.1 6.8 1.3 665290 & ? 66..42 66..30 6.1 6.3 6.3 63 6.4 5.9 6.5 5.5 6.1 6.7 65253 2& 88..360 78..420 77..160 81..060 7.30 665286 2 76..0500 76..5500 76..7100 67..9100 67..8000 66..8000 77..6500 7.40 6.50 66521 & 2 78..8000 77..3800 77..5300 77..3800 77..6900 7.70 7.50 665186 2 78..8200 78..3300 78..2800 87..0700 78..7300 8.00 6.80 665330 &2 66..5000 55..6400 56..9800 66..1600 76..0300 56..4900 5.80 5.70 665294 & 77..7900 77..8700 77..5000 7.30 6.90 7.40 6.90 7.90 7.00 8.16 7.30 665244 & 77..8300 77..2600 77..6200 7.40 665258 &2 76..3500 77..2500 78..1100 67..4700 68..8000 74..0500 7.30 ~~ Ome pup was misexed on Lactation day 0; datawer excluded fom the mean umofmb aleae ndfer male pups per liter, - Bn Company Sanitized. Doesnotcontain TSCA CBI 9F02D54a2y5:GoSvubeehSatndiyc TinoxRiacittyvith OneGenerationReproduction Evaluations Dupont11418 ~~ INDIVIDUAL PUP WLEaIcGtHaTtSio(ngrDaamys)0: 1 GENERATION Group: VI-0 Dose: 100 mg/kg/day JAnriimpaall BPup, 5; 3 4 0s L6upNu7mber8 9 1012m13 665338 5..4200 56..3300 55..9900 66..3400 66..3700 65..5500 66..6000 46..8100 4.00 665219 665267 82 78..8000 7.90 7.30 8.20 7.50 8.20 6.80 6.50 8.40 8.00 7.60 7.30 5.40 665325 & 68..5100 6.30 7.30 6.90 9 6.40 6.60 6.40 6.10 5.90 6.40 6.40 5.90 665331 &? 66..8900 76..3700 77..6600 77..5800 77..6500 67..8700 7.10 7.70 665217 & 2 55..8300 56..4300 65..3300 55..6300 46..8200 65..0700 56..4400 6.20 6.30 665227 2 77..3000 87..8400 77..6600 78..9000 7.60 7.10 7.70 7.80 7.30 665262 88.3900 8.00 8.50 9.00 665247 78..4000 78..4100 78..5000 88..1300 77..3200 78..4300 7.90 ~ 665263 2 78..7400 77..9500 86..0000 77..2700 7.70 8.30 665312 2 77..0300 66..9700 76..2700 66..7900 6.80 6.90 7.30 6.60 es208 & Wwee 665207 & 66..5800 56..6700 66..0800 66..3600 76..4000 6.10 6.30 6.10 6.40 665273 8.50 8.50 9.20 8.80 9.00 2 8120 8.40 665274 67..7000 78..4400 78..1000 76..7900 77..4000 77..2900 7.00 6.50 665272 76..4900 77..6000 78..7400 77..4700 77..3000 8.40 665195 & 66..1400 56..4300 66..0300 66..3500 66..1000 65..3700 6.00 6.40 6.90 65314 750.7800 88..2400 86..6700 67..0900 78..8600 78..0800 77..5900 6.90 B 665316 665173 4 & 66..1200 6.60 76..0300 5.70 66..7600 6.00 66..2700 6.00 65..2200 6.70 6.50 6.20 6.60 7.00 7.00 6.80 6.40 6.60 7.10 6.90 7.306.40 6.80 2 6.005.60 6.00 5.80 --~ J ETH -------- Company Sanitized. Does notcontain TSCA G81 9F-02-5D4a2y5:GavSaugbechSotnuidcyiTnoRraictistywith One-Generation Reproduction Evaluations Dupont-11418 --_ INDIVIDUAL PUP WLEaIcGtHaTtSio(ngrDaamys)0: Fi GENERATION Group: VIII-0 Dose: 1000 mg/kg/day anid Tp Ser 1 2 3 4 E5upNu6mber.1 8 9 10 1 665296 &2 671.1200 66..7300 67..8000 66..5700 66..7500 67..7000 6.50 665193 2 7.10 5.30 65..6400 64..8500 75..1200 67..1200 57..0400 66..2100 6.90 665320 & 53..7500 55..7500 45..9900 56..8400 65..1500 56..4700 55..8700 6.00 665315 &2 66..6200 66..6400 66..4400 56..6300 66..2500 6.70 665318 23 56..8800 76..4500 56..6600 66..1200 67..5000 66..4300 66..5500 67..2200 6.80 6.60 665279 & 6.70 6.50 7.20 6.50 66..3700 66..3700 66..1300 66..1500 56..0200 6.40 6.70 6.50 e520 WwPe 665254 2 78..3000 77..6800 78..0000 77..2600 77..3200 7.30 5.00 7.60 6.80 6.10 665245 &2 77..6500 78..5000 78..7200 77..9000 8.60 8.00 8.20 7.70 ~~ 665322 &2 66..4700 67..8500 76..0300 7.20 6.40 7.40 7.20 7.30 665214 &2 66..6500 65..8200 66..8600 66..6700 7.00 6.30 6.80 6.20 6.70 665321 & 2 66..5400 56..6700 56..1100 66..3700 65..3800 66..2600 6.50 6.90 6.40 665171 2 88..3500 89..3400 87..5600 665265 24 78..2100 77..6800 77..0300 76..2400 77..3500 55..6000 78..0000 5.90 7.80 665169 665191 &2 & 56..8300 6.60 66..2800 6.30 66..0200 6.20 56..9800 5.60 55..1500 6.30 66..5500 6.30 66..8600 66..5100 66..6000 6.60 665231 ? & 5.50 6.50 6.00 5.80 5.80 6.70 5.50 6.60 6.20 7.00 6.80 665255 & 6.60 6.90 5.80 6.20 6.10 6.50 6.30 6.90 6.30 6.20 66..5300 65..6800 6.80 6.70 7.30 6.40 665213 & 5190 7.00 4.20 6.40 5.80 6.30 66..0300 66..1500 66..0000 6.30 665280 75..3800 75..0300 56..6900 75..4300 76..4300 75..1600 76..4000 6.40 5.70 2 6.10 7.20 6.70 6.70 6.80 6.20 6.60 5.90 6.40 -- --_-- Be CompanySanitized.Doss notcontTSaCAiCnBI 9205D4a25y:GaSugbeehvSowndiyc iTnoRxiacsitwyithOne-Generation ReprodusionBastions DuPont 11418 ~ INDIVIDUAL`LPaUcPtaWtEiIoGnHTDSay (&grPamrse)c:ulliFyngGENERATION Group: 11-0 Dose: 0 mg/ka/day Manb ipal SPusp 1 2 3 a4 Pup5 Nunb6er. 7 8 9 10 665220 665336 &2 & 51.06.05 10.9 910..330 12.0 91.09.08 11.1 91.08.01 12.7 81.07.06 12.4 911..410 12.1 1100..20 11.4 1102..28 ees2s7 & 1116..72 1151..66 10.7 11.0 10.3 11.0 es175 15.3 10.9 1142..74 1150..26 1150..26 11.3 11.3 11.5 11.4 665336 9 1115.511701.91101.20 1117 10.6 6.70 1101.55 9.40 1101..98 1112..31 1100..20 11.1 ses102 1110..27 1110..66 91.14.09 1101..64 9.60 10.7 8.10 10.8 11.8 ees232 $ 11220.17 1123..43 1112..38 51.29.03 1111..98 13.0 12.9 7.20 665307 &$ 11220.35111083.9 1112..15 1120..05 1132..09 2101..58 11.8 11.8 65246 ? 1121..23 1111..20 1100..48 91.09.06 1112..63 11.9 12.2 11.9 --_ Ges289 8 wwee 6es26a cesies & & 1152.551133.501115.101135.35 14.6 14.8 13.3 12.5 12.0 11.5 9.90 11.8 665206 9 9& 112 11.4 112 11.2 1106 11.3 11312122012 12.3 11010519 111011...605 1112..34 10.8 11.4 9.50 9.80 10.2 9.20 665306 ges226 98 & 9.31300 13.1 1200.55 12.4 1101..23 13.2 1101..45 12.8 99.0400 11.3 1100..64 12.8 1100..02 12.1 13.0 12.3 11.9 12.2 665198 & 10.2 9.70 13.0 8.00 12.3 10.9 9.50 9.70 9.30 11.2 9.60 9.60 8.80 665249 95.5800 99..5700 78..8700 99..6200 99..1200 79..8700 8.00 8.70 6es"2842& 51.00.09 9.40 81.00.08 10.4 81.14.09 8.70 81,16.01 11.3 98..8100 10.0 180.4.03 10.7 7.90 10.2 20:.0 665260 1101..05 91.i4.01 1110..09 1111..07 1111..51 10.7 10.8 10.8 6es203 1101..3719.1130 911..720 10.5 10.2 10.6 10.8 11.4 10.2 9.50 -- - ho `Company Sanitized. oesnotcontain TSCA CBI 9H0-.2D5a4y25G;avSaugbehSvtoundiyc iTnoRxaitcsitwyithOneGenerationReproductionEvaluations ~ INDIVIDUALLaPcUtPaWtEiIoGnHTDSay (4grPamrse)c:ulliF1ngGENERATION Dupont-11418 Group: 1V-0 Dose: 10 mg/kg/day animal Momber Pup Sev 1 2 3 4 5PNupum6ber7 8 3 0 1 es212 1112..511131.62 1102..51 911..860 11.4 11.6 10.6 10.1 esi60 1110..26 1100..48 1101..42 1110..19 11.4 12.6 12.0 11.1 6esas2 2 1176..38 16.0 665187 $ 91.08.04 91.05.04 1100..95 11.0 10.3 10.3 10.7 11.3 11.0 9.70 665205 & 1132..68 1122..03 12.2 11.2 12.8 11.9 10.9 665263 & 11020.77 81.2.230 1110..19 11121.90 1131..36 1103..92 1120..70 1112..84 665210 & 1100..09 1100..31 190..670 1110..00 1101..50 81.05.02 es161 2 11200..23 91.18.04 1101..34 1101..13 11.0 11.8 11.2 10.5 10.7 665248 2 NNoo LLiivvee P2uuppss ~ 665203 & 9 13.1 1202 12.9 12.7 12.3 12.9 12.5 12.5 13.1 12.7 12.7 12.8 12.40 665320 9 1133..08 1123..74 1133..21 1132..15 1133..97 13.4 11.4 13.8 665290 & 2 11.2 1009 10.5 10.4 11.1 9.90 11.0 8.60 10.7 10.0 10.8 9.30 11.0 12.0 665253 9 1155..72 1143..28 1155..04 1145..69 13.5 665286 2 11210.07 21021.35 1101..22 1102..71 11.5 10.7 9.40 11.0 10.8 9.80 11.4 9.80 665261 &9 11220.59 11221.96 1122..30 11321.79 13.1 12.2 12.4 12.4 65166 & 11331.12 1113..33 1133..66 1123..54 1132..61 13.0 12.6 3 665330 11021.41 1120..26 99..9500 1102..43 1110..23 190..520 10.0 10.3 665294 & 14.8 13.4 7.60 9.20 1318 10.5 13.2 12.8 13.5 15.0 13.00 : 665204 & 1141..99 1140..47 1350..15 665258 4 14.2 13.4 15.0 12.8 14.0 13.3 14.5 14.0 7.00 13.8 1113 130 12.7 13.1 12.6 12.5 12.1 ~~ -- Toa Company Sanitized. Does not contain TSCA CBI 9H02-5D4a2y5G:aSvuabgeehStoundiyciTnoRxaitcstywithOeGeneration Reproduction Evaluations DuPont 11418 ~ INDIVIDUAL`LPaUcPtaWtEiIoGnHTDSay (4graPmrse)c:ulliFnigGENERATION Group: VI-0 Dose: 100 mg/kg/day aMniigapl rPuBp 1 R 2 3 a 0s P6upNu7mber 8 9 10 wu 12 013 665338 3 98..6300 88..1300 81.08.00 67..4100 89..2900 91.05-00 99..5100 99..6100 8.20 665219 Ges267 & 1156..64 12.7 16.0 13.6 15.0 11.9 16.6 11.9 6.30 13.4 13.1 13.3 13.1 665325 11111.85 10.4 1101..84 51.17.00 1101..42 10.5 10.0 20.7 11.1 665331 94 1101..78 2101..72 1113..73 91.17.07 1101..46 1111..49 11.8 20.8 665217 & 91.03.00 81.01.07 51.06.00 89..8500 89..4800 88..6500 10.6 3.90 9.10 6e5227 6 11210.65 1122..68 1122..74 1133..44 1122..95 1133..62 14.1 ses262 8e 1156:.25 16.2 17.1 16.1 Ges267 11260.61 1133..15 1132..33 1126..13 1124..53 1133..22 12.9 ~~ 665203 11340.82 1144..72 1140..60 1144..28 11.2 14.1 esatz 13.3 13.2 12.5 12.5 12.5 13.0 13.2 11.8 126 12.6 11.3 13.2 es208 &? wwee 665207 1121..29 1101..72 1111..10 2100..61 1110..52 11.0 10.1 10.5 e523 & 1166..86 1123..76 16.8 15.3 13.6 g6s276 & 11110.77 1112..06 1122..96 1122..95 1111..24 1111..09 12.6 11.2 ges272 & 1121..78 1111.77 1121..48 1121..01 2102..90 12.5 gesi95 & 151..510 1102..64 55..8900 2103..66 1111..55 1111..26 10.4 11.1 10.9 esata 13.1 13.6 14.8 12.7 13.3 12.0 13.2 + 6es3t6 9 & 13.0 9.20 12.0 10.6 12.6 11.4 10.8 11.5 20.2 10.6 12.2 9.50 12.0 10.4 13.1 10.4 10.6 10.7 665173 & 91i..520 1112..39 91.01.00 81.07.60 71.04.00 11.1 10.8 20.6 10.1 10.9 11.6 11.5 12.5 10.6 10.6 10.9 5.60 -- - TaCompany Sanitized. Does not contain TSCA CBI 9H02D54a2y5:GavSaugbeehSvoundiyc iTnorRiactistywith One-Genration Reproduction Balustions DuPont11418 ~ INDIVIDUAL`LPaUcPtaWtEiIoGnHTDSay (4graPmrse)c:ulliFingGENERATION Group: VIII-0 Dose: 1000 mg/ka/day aMniipnatl BPop21 2 3 a4 P5up Nu6 nber7 8 9 10 1 6es296 & 1100..69 1100..87 1101..25 1101..33 1110..06 1101..25 11.3 es193 & 1100..80 190..350 81.02.08 91.04.04 81.18.05 1112..51 1110..51 6.60 665320 & 591.3600 58..4400 81.02-08 910..020 88..4900 89..8400 79..9100 esas 665318 98 @ 111i..31 9.10 1101..16 8.00 1100..48 9.60 1101..96 11.3 2101..86 10.3 10.3 10.3 9.40 10.7 10.9 9.90 ese @$1611..78 10.6 71..470 10.2 1810.1.8.800 911.006..029 91.37.00 9.80 130.5.05 7.70 91.12.05 11.2 8.70 10.4 8.10 12.0 ses22a es2se owNe 12.0 11.1 12.7 12.5 12.2 gss265 5.20 13.2 2103..37 1122..00 1113..23 11231.36 1103..95 61.36.00 1103..11 11.3 10.7 - es322 9 & 12.1131 13.4 13.1 12.6 11.7 117 11.9 12.2 12.7 12.7 11.9 1211.4 1217 ees214 $ 11020.71 1111..78 1111,.00 1100..77 1131..75 1111..09 11.6 665321 & 810..900 93..1900 99..9700 910..440 91.06.06 81.08.08 10.3 11.0 5.50 ces171 1176..06 1156..03 1176..10 665265 &2 78..8900 71.06.10 78.13700 86..9700 96..3400 59..0900 81.11.03 9.40 66s169 seston 9& 1110..15 10.2 1111..88 10.2 51.15.00 10.8 51.19.00 10.9 2100..04 10.3 51.12.05 10.7 1100..13 1100..85 1110..65 20.1 . es231 2 8 10.1 1101..15 5.00 1101..59 9.70 91.07.07 1910.0.6.105 191..710 193..940 1110..42 gos255 2@ 51.09.06 1100..02 51.30.06 91.00.06 10.3 10.0 10.1 6.50 1118 20.2 11.0 10.7 9.30 665213 & 1101..20 1110..40 990.5000 190..560 11.3 10.9 10.7 9.90 10.2 8.40 3.40 9.00 665200 &2 1112..63 1102..35 1103..36 1112..26 1131..07 1112..74 1111..27 10.2 10.1 ~~ J Tne ---------- CompanySanitized.Doesnot contTSaOAiCBnI 5H02.5D4a2y5;GavSaugbcehSvtoundiyc iTnoxRiactistywithOGneeneration Reproduction Evahations Dupont 11418 ~~ INDIVIDUALLaPcUtPatWiEoInGHDTaSy (4grPaomsst)c:ullFiingGENERATION Group: 11-0 Dose: 0 mg/kg/day aNniirmbaelr SPeuxp 1 2up N3umber4 5 665220 2& 51.03.05 81.07.03 91.04.08 1100..02 665334 ? 1112..06 1110..17 12.4 10.3 12.1 11.0 665257 3? 1165..23 15.6 14.7 15.2 15.2 665175 1121.54 1111..76 1111..32 1111..55 665336 &2 61.17.00 91.14.08 1102..91 1100..20 es152 & 11.2 10.7 11.6 9.40 11.9 9.80 11.4 9.10 es232 & 1123..43 1121..38 1133..30 11.9 12.9 665307 2 1123:.39 1132..05 2102..50 1111..88 665206 2 11211.23 1101..08 1101..49 11.9 206 ~ 65289 &ewNe ses264 &? 1152.55 1135..40 1141..61 1134..38 65185 & 1121..52 12.0 11.6 9.90 12.3 11.8 11.0 665206 &2 1101..241101..62 1110..83 10.5 10.2 665306 & 91.13.05 911..030 190..460 1100..40 665226 1130.21 1133..20 1122..38 11.9 12.20 665198 & 2 8.00 9170 10.9 8.70 9.70 9.20 11.2 9.70 665243 & 2 97..0800 9.10 8.80 7.80 8.60 8.00 8.40 665284 10.9 16.8 11.9 11.1 . 665240 % 51.17.05 19.12.03 1100..90 20.7 11.5 665203 &2 1111.070 1111..13 1101.027 10.8 2 10.5 10.2 10.6 10.8 9.80 -- e-- e ----------HE------ ee -- -- ---- ---- -- `Company Sanitized. DoesnotconTtSaCAiC8n1 525025: SubchoneToxicity _ INDIVIDUALLaPcUePatWiEoInGHDTaSy (4grPaomsst)c:ullFiingGENERATION Grow: 19-0 Dose: 10 ma/ka/day MAneimbarl P3u2p 1 2 Pup3Numb4er 0s 6 gesa12 ges100 8% 4 1112.1511111.66 10.9 11.4 1110.54 12.0 92.00.06 3i.1 gos22 8 1170.63 1160.008 1004 1011 Ges107 28 1106.6 10.9 0041005 11000.73 1111.030 ss20s sesa6r 3 111322..678181.222.003 111122.227 1121.189 11.8 gss210 1202.39 113091 1101060 2210.000 Sesie1 9%8 1510.1.63061911.16.300 121001..1532 23800...5170 sesaas 5& Nwoo Lviivvee Puuppss --_ sesas3 1132.171122.39 12.9 12.5 13.3 12.7 gss329 ' 1132.74 11322s u1l311139ie gss200 gosass 4% 11011521100.54 15.2 13.8 91.19.0153.1300 15.4 15.9 sesas 8 % 1125.7514110.22 12101013 1151.50 10.7 1106.68 9.50 gesaer $ 11221.s6 1122.70 1123..69 11230.41 geste ses330 1103.21133036 3 12.6 12.3 112035.6 10.3 1133..40 9.50 . seszsa % 1030.2491.02.04 1131..22 1120..80 15.0 nls 2007 100s gesaas gosase 3 1140.2315140.04 12.8 13.3 1154.010 14.0 1136..85 minnie ls -- i EER-- E ------n-- e -------- `CompanySanitized. Does notcontainTSCA CBI 0H--2D5a4y25G:avSaubgcehSrtoundiyc nToxRiactistywithOne-GenerationReproduction Evaluations --_ INDIVIDUALLaPcUtPatWiEoInGHDTaSy (4grPaomsst)c:ullFiingGENERATION Group: VI-0 Dose: 100 mg/kg/day N animual mSPeubxp 1er2 P3upHu4rber5 7 665338 &2 88..8600 68..4300 99..5900 89..2100 665215 2& 1156..64 16.0 15.0 16.6 665267 12.7 13.6 11.9 8.30 13.4 13.113.3 es 665325 2 11010.45 1110..48 1101,.00 11110.12 665331 1101..72 1112..73 191..790 1111.84 665217 2& 51.03.00 81.01.00 88..6500 89..6900 665227 &? 1121..65 1132..48 1132..49 1123..52 65262 & 16.5 16.2 17.1 16.1 e152 665247 1123..61 1132..33 1124..311134.32 m 665203 1134..82 1148..27 1144..06 14.8 14.2 665312 121.2.65 1122..65 113.10 1.1313..82 e528 & Nwee 665207 & 12.2 11.2 10.7 11.1 11.0 1011 10.6 10.5 665273 1166..68 1123..76 16.8 15.3 13.6 665274 9 1111.77 11220.86 1122..99 1111..94 665272 9 1111..77 11120.84 1121..01 1102..95 . 665195 9 59..9800 1103..66 1111..55 1110..29 65314 1123..01 1124..68 103.32 1122..20 665316 2 99..5500 91.01.04 10.6 8.70 10.7 7.40 665173 & 1103..69 1100..60 1100..96 91.16.05 DuPont 11418 - --~ 26 -- CompanySanitized. DoesnotconTtSaCAiC8n1 9H02.5D4a2y5G;avSaubgcehSrtourdiyc TinoxRiactistywith OneGenerationReproduction Evaluations Dupont-11418 ~ INDIVIDUALLaPcUtPatWiEoInGHDTaSy (4grPaomsst)c:ullFiyngGENERATION Group: VITI-0 Dose: 1000 mg/kg/day Nanuimmbaelr SPeupx 1 2Nupun3ber4 5 665296 & 10.7 10.8 11.5 10.3 11.3 11.0 10.6 11.5 665193 &2 1100..80 910..450 51.12.05 181..605 665320 2 39..4300 910..420 88..4900 89..8400 665315 ? 1110.111 1101..46 111006.8 1110..36 665318 &2 87..0400 91.15.03190..230 10.9 8.70 665279 & 1101..88 1101..90 91.16.20 1122..00 e524 8? wwep es25 & 11221.00 1101..91 1102..17 12.2 11.3 66525 1122:.10 11330.16 1123..60 1113..71 --_ esaze 11131.21111174 1122..72 12.7 11.9 65214 9? 1112..71 1111..08 1101..70 11110.05 665321 &2 98..7900 190..104 10.3 9.90 11.0 9.40 6s171 &2 1167..60 1165..30 1167..01 665265 7.30 8.90 10.16.70 6.40 9.00 11.3 8.10 6esies &2 1111..88 91..900 810..240 1101..86 ester 2 1100..2181.00.03 91.07.10 10.5 9.60 665231 2 91.17.09 1100..15 191..710 1101..24 ges255 2 91.00.06 10.6 9.00 10.3 10.0 11.0 6.50 5 665213 & 2 9.00 10.2 10.6 10.0 11.3 9.40 10.7 3.00 665280 2 1112..65 2102..96 1102..36 1121..41 --_ Co---- Treee-- Ste -- er-- er `Company Sanitized. Does not contain TSCA CBI 9H02.5D4a2y5:GaSvuabgcehrSotruidycTionxRiactistywithOneGeneration Reproduction Evaluations PS INDIVIDUAL PUP WLEaIcGtHaTtSio(ngrDaamys)7: Fi GENERATION DuPont 11418 Group: 11-0 Dose: 0 ma/ka/day aRnaibmearl Pup Sex 1 2up N3unber4 5 ees2z0 9& 1167..39 1146..94 1167..11 1177..12 665334 2118..30 1197..36 2108..59 1178..55 665257 8 2244..00 26.4 22.7 23.9 23.3 665175 9& 1179..22 1187..18 1177..86 1177..88 665336 1178.148 1290..07 1191..49 1197..35 6es192 1157..80 1177..30 1174..04 1148..21 s232 & 220025.2 2212..33 2201.96 1199..79 665307 2203..51 22010.51 211.95.0 2201..47 665246 1187..53 1197..00 1179..81 1177..56 sass wNee es264 9 2222.135 2232..90 2233..92 2193..26 6es185 2118.171 1169.006 2108..27 19.7 665206 2 11790.63 1189..72 1169..53 1179..21 665306 9& 1189..59 1175..49 1176..94 1186..33 665226 9 1207..842109.98 2200..89 21.2 21.20 esi98 ? 1167..52 1166..41 1178..11 1157..02 . es2as ? 1154..20 1142..55 1135.34 1153..23 ees284 & 17.117.4 17.3719.1 es240 ? & 16.2 15.1 1178..69 1184..82 1175..33 - 665203 & 1177..23 1178..93 1177..32 17.7 2 15.8 16.7 16.1 17.0 16.90 ~~ - Tse Company Sanitized.DoesnotcontTSaCAiCnBI 0H2-5D4a2y5:GavSaugbeelSvtoundey TinoxRiactistywithOneGenerationReproduction Evlustors DuPon11418 ~ INDIVIDUAL PUP WLEaIcGtHaTtSio(ngrDaamys)7: F1 GENERATION a bose: 10 mg/kg/day MAnoihpearl SPeuxp 1 2 dupu3mbe4 r 5 6 ges212 $19180.35 1176..86 1187..05 1178..57 e510 $ 1190.291178.98 1188.171 2107..09 ces29z &e2202.39 25.4 Ges197 1178.08 1178..16 1187..15 11880.32 665205 11880.50 1176..16 1178..42 119.75.0 665263 2117..182210.68 1196..29 1290.36 665210 1166..64115.5 1 1165. ..3511356..35 este &% 1169..111197..48 1177..52 1186..97 665248 Nxoo LLiivvee PPuuppss ~ 6es203 4 2210..54 2210.033 21.3 20.5 20.1 20.1 Ges320 22.1 21.4 215 21.6 665200 9 2117.38 1270..61 21801.15 1272..28 ges253 4 2151..52 2127..49 2163..46 2117..60 ces2ns 2181.16721170.87 2190.03 21181.54 Ges2e1 11080.1112700.69 1179..80 1187..92 gos166 2108.83 2191..012171.28 2108..37 g65330 8 12080178202070.0 1198..46 1260..52 ses294 $4231.73.91176.30 2115.3411671.42 20.6 - ees2a4 5 2119.055 2128..31 2128..66 ses2s8 2212.1622110.88 2211.48 1290..68 20002000 19.3 19.9 --~ e-- e ----------Te--m-- is-- ame --g-- e CompanySaniized. Doesnot contain TSCA GBI 9H02-5D4a2y5G:avSaugbecShtruodnyciTnoRxaitcsitwyithOneGeneration Reproduction Evaluations ~ INDIVIDUAL PUP WLEaIcGtHaTtSio(ngrDaamys)7: F} GENERATION Group: VI-0 Dose: 100 mg/kg/day Mniianbaelr SPeukp 1 2 u3 pNuanber5s 6 7 Ges330 91.50.03 1136..94 1160..38 1144..88 665219 665267 & & 2230.071222 21.4 19.7 2231..63 2200..02 20.2 20.7 15.9 665325 9 & 18.6 18.6 17.2 17.4 18.1 65331 @ 1260..41 1166.158 1197..83 1386..48 Ges217 821195..131187..631179.83 1197..11 Ges227 & 2116..77 1184..74 1216.32 11490.99 65262 &9 2159..73 2250.38 2216..71 2240..82 e527 2230..46 20.5 26.0 22.1 665243 2211.162221.25 5 2211..42 2211.41 ~ es312 & 1290..48 2200..09 2200..98 2109..94 20.2 19.7 1808 21.2 e528 8 wwee 665207 &$12710.20 11980.13 119.85.6 18.1 17.9 665273 & 2137..512211.55 19.8 23.5 20.5 s6s27a & 2210.000 210081.7 2108..59 2200..78 665272 & 11870.23 1168..26 1197..34 118.85.3 . gesios % 118097.7 1261..74 1179..87 1166..46 665314 & 21.6 22.1 20.6 23.0 - 665316 @ 2108..44 1166..59 1197..88 2170..29 Gos173 & 1176..45 1128..68 1177..20 2105..41 ? 1616 17.3 16.0 18.0 DuPont 11418 : -- --------------0-- eerie----------e-- et `Company Sanitized. Does not contain TSCA CBI 92054Da2y5:GavSaubgeehSrtoundiyciTnoxRiactistyvithOGneneration Reproduction Evaluations ~ INDIVIDUAL PUP WLEaIcGtHaTtSio(ngrDaamys)7: Fy GENERATION Group: VIII-0 Dose: 1000 mg/kg/day Mainnibpearl SFouxp 1 2upNu3mbera 5 665296 % 1168..80 1176..42 1178..63 1187..09 Ges193 1176..03 1157..24 1183..80 1189..82 665320 &% 1145.1821154.54 1146..59 11350.63 g6s315 3S 1174.41168.55 1198..97 1187..73 ges3te 4 1166..88 1184..23 1147..85 2122..86 Ges279 1291..01 1186..35 2109..50 2109..05 es224 & mwwe ges254 $22101.32 2127..20 1291..32 1199..02 Ges205 1201..43 1189..56 2201..80 1209..75 ~ 665322 2 1109..67 1198..07 1270..83 18.4 19.5 Ges2ia 18.3 185 19.4 18.1 es321 @ 1106..511187.10 1168..78 1177..12 esi7 ? 2145..36 2126..60 1244..89 15.2 665265 252..670 1243.054 92.38.00 15.8 Gesies 1127..05 1182.068 1194..82 110.90.6 1305 18.2 16.8 19.8 Ges191 1166..46 1166..26 1166..93 1154..74 . 6es231 1186..02.1157..99 1166..10 1157..70 6ss2ss 4 17.116.0 16.5 18.3 e523 11761.58 1167..28 1157..96 118.13.5 665280 2107..82 1186..98 2114..04 1195..30 18051709 19.1 17 Dupont 11418 . ~~ i-- ee------Tepr---- CS -------------- `Company Saniized. Doesnot containTSCA CBI 9H02.5D4a2y5G;avSaubgeehSvtoundiyc TinoxRiactistywithOne-Generation Reproduction Evaluations DuPont 11418 ~ INDIVIDUAL PUP WLEaIcGtHaTtSion(gDraamys)1:4 F1 GENERATION Group: 11-0 Dose: 0 mg/ka/day Mnuimrbaelr S2epx 122upNu3mber4 5 665220 3345..66 3365..08 3355..96 3325..61 665334 &? 4317..00 3387..62 3388..57 4326..26 6es2s7 8o 4497..96 4477..98 48.6 46.3 Gesi7s 3365.1853355..74 3354..85 3345..75 e536 3365..89 3292..90 3307..89 3387..98 esis2 9 3326..28 3355..99 3323..09 3324..76 ses232 44320.08 4318..03 4401..02 4422..63 665307 & 4411.1014421..06 4403..01 4308..84 Ges2e6 & 3322..28 3323..82 3312..75 3313..46 ~ ses280 @ wwpe Ges260 45.3 44.1 46.8 43.6 esies 9 4328.075 4432..39 4337..88 4339..13 665206 & 3481.85 3492..74 8307..28 38.6 665306 9 & 3395.51 3356..05 3387..06 3356..54 g6s226 & 3442l.94 4308.83 4317..19 4317053 40.50 Ges198 & 4361.174400.12 3367.89 37.9 665209 & 3375..36 3355..64 3337..20 3352..98 3 Ges204 3355..86 3335..62 3358..83 3355..46 - 665200 & 337a.l85 3397..62 3369..75 3311.25 665203 3346..99 3357..70 3346..82 38.0 3418 34.5 33.3 36.5 34.00 -- --or -------------------- EE-------------------- CompanySaniized. Does notcontain TSCA CBI 9F0-2D5a42y5:GaSvuabgcehvSotnuidcy iTnorRiactistywithOGneneration Reproducion Evaluations Dupont11418 --~ INDIVIDUAL PUP WLEaIcGtHaTtSion(gDraayms)1:4 Fi GENERATION Group: 1V-0 Dose: 10 mg/kg/day animal Miner Pup Sew 1 2 Nupu3 mbe4 r 5 6 -- 3 es212 3336.80 3367..35 3337..50 36.0 35.1 665180 & 4391..71 3398..72 4400..76 39.0 39.3 665202 & 49.0 42.6 a2 es187 & 3376..05 3366..48 3366..46 37.9 35.5 665205 3352..473345..83 3348..93 3364..86 665263 3471..22 3399..88 3470..72 4301..44 ges210 & 23920.80 3311..38 2382.163 32.6 32.0 665161 3387..26 3345..15 3387..08 3348..39 665248 8 No No Live Live Pups Pups 6es203 8 42.3 42.2 42.0 42.2 38.3 39.8 41.2 40.8 665320 45.2 43.6 43.0 42.5 4442..48 4431..32 665200 &2 3368..40 3377..51 3366..59 36.4 35.3 6es2s3 4431.374421.37 3490..48 42.6 403 665286 &? 3376..633358.58 3356..35 3357..00 eesasL 2 3367..89 3365..81 3368..99 3406..50 6esiss 3378..68 3407..70 3389..69 3389..43 665330 3471..143377..52 3395..32 3395..00 es200 9& 3428..203397..99 3492..11 38.0 42.6 6es2ea 40.2 40.9 41.6 - 665258 4318.1223398.30 3396..47 3398..29 38.637.4 38.0 37.9 -- --_ one Company Saniized. DoesnotcontainTSCA CBI 9H02.5D4a2y5G;avSaugbcehSrtoundiyc iTnoiRcatistywith One-Generation Reproduction Evaluations Dupont 11418 -- DIDIVIDUAL PUP WLEaIcGtHaTtSion(gDraayms)1:4 Fi GENERATION Group: VI-0 Dose: 100 mg/kg/day NAinmibmealr SPeuxp 1 2 3Nupum4ber5 6 1 665338 3332..29 2374..44 3344..36 33.0 665219 2 4454.137 41.9 44.0 43.0 665267 & a42r.s7 43.8 49.9 42.4 42.8 32.7 42.8 665325 9& 3374..203376.71 3356..18 3346..60 665331 9 3379..93 3481..82 3396..06 3385..55 65217 3358..32 3384..19 3305..75 38.7 33.2 665227 & 3377..26 4307..69 3399..13 37.3 39.0 65262 & 4187..28 49.0 48.9 47.7 665247 & 4414..54 4403..65 4423..29 46.7 42.2 -- 665203 2 3399.0513399..96 3409..19 3388..44 665312 9 4400..57 4401..21 4411..35 4400..49 es208 & we we 665207 2 40.9 3413 38.5 37.3 38.9 36.5 36.5 38.6 665273 ?& 3350..94323.3.3 32.7 35.8 32.7 es274 4381..313419.50 4421..12 3409..70 es272 3374..75 3377..53 3367..47 3368..71 665195 3387..543492..86 3389..26 3450..79 665314 & 46.3 45.5 46.1 43.8 + 665316 43.9 36.3 37.9 36.7 41.1 37.3 42.3 36.9 665173 & 4315..562388..54 3450..76 3348..42 3812 37.2 37.6 37.6 ~~ e-- e --------5---- pie es-- te p -- S-- CompanySanitized. Does notcontTSaCAiCnBI 9205-4D2a5y;GaSvuabgechSrtoundiyciTonxRiacistwyithOneGeneration Reproduction Evaluations DuPont 1418 - INDIVIDUAL PUP WLEaIcGtHaTtSion(gDraamys)1:4 Fy GENERATION Group: VILI-0 Dose: 1000 mg/kg/day NAonmimpaelr Psuepx 1 2upf3er4 5 665296 ? 3388..313365..38 3345..23 3366..79 665193 & e39l.e0 4312..36 3393..86 3260..36 665320 3311..863321.57 3313..17 3302..45 665315 9 3375..643386..65 3346..51 3335..59 es31s 3327..90 3358..14 3308..87 3330..49 665278 & 4329..63 3490..22 4329..66 4412..29 65220 82 WWwe 65254 & 3490..37 4414..40 4319..30 3493..74 665245 & 3419.0753461..90 3399..47 4400..75 --_ 665322 9& 3387..673385.34 3388..06 40.4 37.6 665214 2 3377..54 3366..16 3368..04 3388..36 es321 3335..193234..86 3333..42 3325..33 s171 &? 4445..69 47.7 43.7 47.0 40.5 665265 & 2279..43 3336..27 2255..39 2372..96 es169 & 4308..96 3390..69 3359..96 3379..35 665191 & 33341.64 3331..48 3344..90 3343.75 . 665231 3386..32 3357..84 3377..98 3386..30 665255 & 2396..93 3384..28 3368..52 3368..47" 665213 & 4306..26 3388..36 3379..55 3369..91 665280 &2 3417..353399..67 3492..53 3482..94 --_ -------------- Tse ---- eer---- ---- -- -- CompanySanitized. Doesnot contTSaCAiCnBI 9H02.5D4a2y5:GaSvuabgeehvSotnuidcy iTnoxRitcsitywithOneGeneration Reproduction Evaluations DuPont 11418 ~ INDIVIDUAL PUP WLEaIcGtHaTtSion(gDraamys)2:1 Fi GENERATION Grow: 11-0 Dose: 0 mg/kg/day Mainnibpearl sPeuxp 12PupNu3mber4 5 665220 & 5533.58 5554..25 5536..45 5540..80 665338 4 6624..23 6 69.406712.. .7056954..81 6es257 8 7798.186 78.4 79.5 76.1 74.8 Ges175 @ 5662..74 5575..47 5586..51 5563..27 665336 & 2616.73 6548..70 5653..11 5680..13 665102 & 5503.029 4586..38 5526..64 5523..93 65232 & 6688.121 6634..23 6699..14 6658..84 665307 & 5695..88 6642..53 5684..64 6614..06 665246 & 5566..65 5546..45 5592..04 5535..55 --- ses289 & mwew e520 7744..66 6719..50 7625..97 7705..76 Gos18s & 6641..416519..73 5658..20 65.0 665206 & 6518..02 5636..67 6513..31 5598..6 665306 5587..44 6603..26 5564..20 6505..08 665226 6673.60 6641..74 5663..83 64.5 67.40 665198 5682..34 5566..64 5685..97 6526..46 665249 &9 5545.075532.96 5555..34 5533..26 665284 & 6210 50.7 55.5 43.6 . 665240 5 & 4675..92 5671..43 5654..63 5520..56 665203 & 5660..37 5671..25 5598..36 62.3 9 5613 58.7 54.0 58.1 55.80 -- --_-- TieCompany Sanitized. Does not contain TSCA CBI 2505: StanaTionety OnGeranRprodtion Elution Donuts ~ JR Then h ---- [a sone: 10 narkaday aMosEzatR2Ep, Pup5thnboers qos sosiso 5 B5666o37o 65 62.6 oe20i..3d 6ee1sa.ad6 sesass SSaa70s3r6a0ssa see sseemesnsota60r55a95.81 5a597.33a33n79..69 sesaes 3feansrecahe sn67e3 4saa5an gone semen 34$Se0oas eseeisas aseehrsos s5soo6z cesatn $H 3 sWogLiave roams se PP ~ sess sesso 359HE6SG5eE.no5 6dmR5b.so2 S65e65..e25 E56v60a.sd4 64.2 59.9 cesass SSe75ar.3echunr a6a3e.0 iseoedn qomse qesans 3$ 3GGod a661563aearaisla 0e.e8d esis 3SSaoEnnsaG65a.3 a60.6s6e0.2 . sesso 3St5a6n33 a651sesad 665294 sesaaa {{4 BB6730re.54a7a642s.a07 a6a71sac.3 a72s.1 63.1 - qesass 3HEeSo 671 630 621 ~ FNEL J ------ 5H02-5D4a2y5G:avSaubgeehSvotniyciTnoxRiactistywithOneGeneration Reproduction Evaluations Dupont 11418 --_ INDIVIDUAL PUP WLEaIcGtHaTtSion(gDraamys)2:1 Fl GENERATION Group: VI-0 Dose: 100 mg/kg/day nPiagpaelr PSepz 1 2 P3upduam4 ber5 6 Ges3ze 8 5563.23 85377.945560.82 50.6 Ges219 gosa67 55 4 77260.35 55.4 67.4 72.7 68.3 75.0 68.1 TL.8 69.7 74.6 69.9 665325 4 6601.4 58.7 61.0 58.2 sls 52.7 55.2 57.0 665331 9 6652.2595.6.20 6614..18 6631..25 ges217 6660..40 6586..27 6516..48 5653..52 ges227 6632..08 6633..34 6616..89 6662..83 Gosa62 3 m78i.1 80.4 80.9 76.5 Ges247 58 6686..30 6701.51 6632..33 7644..30 ~ Gos243 S 6663..26 6671..78 6645..27 6604..60 ess312 8 61.6 67.9 64.7 62.6 6302 66.3 60.8 65.5 ees208 6es207 8 wwee 67.4 66.9 61.1 665273 &$ 6603..32 6607..21 5681..74 5660..56 6568..57 g6s276 S53 6672.23662.09 66.7 64.1 62l5 68.4 60.9 61.9 665272 9& 6610.74 5680..01 5576..71 5554..23 . Go5195 6602.19 5673..45 6549..28 6670..36 ges31a 715 74.1 79.4 76.0 . cosa16 8 5673..24 5687..77 57193..22 5679..76 56.257.2 41.6 513 - 665173 s69a..5 6614..54 6611..11 6607..60 -- --ie-- Company Sanitized. Doesnot conTtSaCAi0nB F9-02D54a2y5:GaSvuabgeehSrtouidcyTionxRiaciistywithOne-Generation Reproduction Evaluations --~ INDIVIDUAL PUP WLEaIcGtHaTtSion(gDraamys)2:1 Fy GENERATION Group: VITI-0 Dose: 1000 mg/kg/day Naunmibmearl SPeuxp 12up Nu3 nber4 5 665296 &9 5690..30 6517..43 5643..30 59.3 58.8 665193 & 6671..76 5541..34 6633..81 5680..39 665320 & 5502..98 4583..74 5551..77 52.3 51.9 665315 &9 6622..02 6505..55 6651..49 66.7 55.9 65318 42 5506..75 6565..01 4598..30 59.0 52.5 665279 & 6629..64 6624..21 6626..11 7604..03 665220 8 nWee 665254 & 7657..28 7678..11 7609..22 73.0 69.3 65245 4 6674..31 6685..28 6666..17 68.2 58.8 -- 665322 61.6 66.7 63.8 65.6 61.4 61.7 63.7 58.8 665214 &9 S555..015548..315507..215556..64 665321 9 6537..265630..23 5559..12 58.4 52.9 65171 7738..21 6817..40 71.1 68.9 665265 & 4464..25 4571..98 5435..86 5569..38 665169 &5 46311.35 6550..24 6615..66 6518..27 665191 & 5670..95 6506..40 5610..87 56.5 56.8 652"731 2& 643.0105587:.23 5662..42 6517..92 665255 &9 4658..615609.85 5680..31 5683..83 665213 &o 5637..476517.32 5672..29 65.9 57.4 665280 & 7624..46 6628..47 5688..36 63.7 64.3 Dupont-11418 - --~ - TI `Company Sanitized. Doesnotcontain TSCA CBI 9H-02.5D4a2y5;GavSaugbcehSrtoundiyc iTnonRiactistywithOGneneration Reproduction Evaluations --~ Dupo 11418 --~ APPENDIX J INDIVIDUAL CMLOINRITCAALLIOTBYSDEARVTAATIINONF;S,MADLEEVAENLODPFMEEMNATLAELRLAATNSDMARKS, AND --~ --_-- TIH0 Company Sanitized. Does not contain TSCA CBI 9205.4D2a5y:GavSaubgeehSrotndiyc iTnoxRiactistywith OneGeneration Reproducion Evaluations DuPont 11418 rTM INDIVIDUAL CMLOINRITCAALLIOTBYSDERAVTAATIINONF;S,MADLEEVEALNODPFMEEMNATLAEL LANDMARKS, RATS AND EXPLANATORY NOTES Note Test Day 1 = Postnatal Day 21 Abbreviation NR = Not recovered; the given sign was observed on the date that the animal died. --~ e--e-------------------- En-------------------- Company Sanitized. Doesnotcontain TSCA CB 99F0-0-2.D5D4aa2yy5G;GaSavuvabagceghSrStotunudidycyiTinnoRxRaiatciisstwywiitthhOOnnee-GGeenneerraattiioonnRReepprroodduuccttiioonnEEvvaalluuaattiioonnss ~ INDIVIDUAL CLINICAL OBSERVATIONS IN PIA MALE RATS GROUP: 1-1 DOSE: O MG/KG/DAY. DDuuPpoonntt-1111441188 ADL ose OBSERVATION OsBISRsETRVDEADY 1OaBSSTERDVAEYD 70186 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN TCEOSMTPLDEATYE 40 670150 SFARCERFIUFTIICAELDSBEYPADREASTIIGONN 7C8OSMTPLDETAEY 40 670154 PSARCERFIUFTIICAELDSBEYPADREASTIIGONN TCEOSMTPLEDATYE 40 670196 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN TCOEMSPTLDEATYE 40 670200 SPARCERFIUFTIICAELDSBEYPADREASTIIGONN TCEOSMTPLDEATYE 40 670204 SPARCERFIUFTIICAELDSBEYPADREASTIIOGNN CTOEMSPTLEDTAEY 40 670208 APLROEFPEUTCIIAALBOSETPHAFRRAOTNITONBACWO(MSP)LETE ASLAOCPREICFIICAEDBOTBHY DFERSOINGTNL3TGE(S5T) DAY 40 ~ 670212 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN TCBOSMTPLEDTAEY 40 670216 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN TCEOSMTPLDEATYE 40 670120 SAPALRCOERPPIEUFCTIIICAAELDBSOBTEYHPADERERASOTINIGOTNNPATCNEO(SMSTP)LDETAEY 40 670226 PSRAECPRUITFIIACLEDSBEYPADREASTIIGONN TCEoSwTpLDEATYE 40 670228 SPRAECPRUITFIIACLEDSBEPYADREASTIIGONN CTOEMSPTLEDTAEY 40 670232 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN TCOBMSPTLEDTAEY 40 20 20 20 20 1 1 2 2 2 25 = 2 2200 020 m 0 fom 2 2 2 zn 326 02 m 20 20 3 2 n 2 ~ Ta: `Company Sanitized. Doesnotcontain TSCA CBI 9H-02-5D4a2y5G:aSvugbechSotnuidyciTnoRxaictistwyithOne-Generaion Reproduction Evaluations Dupont 11418 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN FIA MALE RATS GROUP: 1-1 DOSE: O MG/KG/DAY ANIMAL NNBER OBSERVATION FOBISRESRTVEDDAY LOABSSTERDVAEYD 670236 PSRAECPRUITFIIACLEDSBEYPADREASTIIGONN TC2OSMTPLDEATYE 40 670201 PSRAECPRUIFTIICAELDSEBYPADREASTIIGONN TCEOSMTPLEDTAEY 40 670245 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN CToEwSpTLDEATYE 40 670209 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN CTOESMTPLDEATYE 40 670253 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN TCEOSMTPLDEATYE 40 670257 PSARCERPIUFTIICAELDSBEPYADREASTIIGONN TCEOSMTPLEDTAEY 40 1 1 2 2 2 2 20 20 2 20 2 2 --_ Ta. `Company Sanitized. Does not contain TSCA Cal 31H092-05D-4Da2ay5yG:GaavvSaauggbeceShStrtouunddiyyciTinnoRxRaiacttisstwywiitthhOOnee-GGeenneerraattioonnRReepprroodduuccttiioonnBErvaolluoasttioonnss __ --_ INDIVIDUAL CLINICAL. OBSERVATIONS IN PLA MALE RATS GRouP: TII-1 DOSE: 10 MG/KG/DAY DDiuPPoonrt-1111441158 amo woBE oBsERvATION OFBISRESRTVEDDAY LoABSSTERDVAEYD 670261 PSARCERPIUFTIICAELDSBEYPARDAETSIIGONN CTOEMSTPLEDTAEY 40 670265 PSARCERPIUFTIICAELDSBEYPARDAETSIIOGNN TCEOSMTPLEDTAEY 40 670269 PSARCERPIUFTIICAELDSBEYPADREASTIIGONN TCEOSMTPLDEATYE 40 670271 PSARCERPIUFTIICAELDSBEYPARDAETSIIOGNN TCEOSMTPLDEATYE 40 70275 PSARCERPIUFTIICAELDSBEYARDAETSIIOGNN TCEOSMTPLDEATYE 40 70279 SPARCERFIUTFIIACLEDSBEYPADREASTIIGONN CTOEMSPTLEDTAEY 40 70283 SPARCERUITFIIACLEDSBEYARDAETSIIOGNN CTOEMSTPLDEATYE 40 ~ 70287 SPARCERSIUFTIIACLEDSBEYBADREASTIIGONN TCEOSMTPLEDTAEY 40 70291 APRLEOGPUETCIIAALBOSTEHPAFRRAOTNITONPCAWO(MSP)LETE SACRIFICED BY DESIGN TEST DAY 40 670095 TSORREEFULTEIPATL SFERPOANTRATPAIWO(NS)COMPLETE `SCAOCLROIRFEIDCEDDISBCYHADREGSEIGNNOS7E2SRTEDDAY 40 670299 SPARCERSIUFTIICAELDSBEYPADREASTIIGONN CTOEMSPTLEDTAEY 40 70303 PSARCERGIUFTIICAELDSEBYPARDAETSIIOGNN CTEOSMTPLDEATYE 40 70307 PSARCERPIUFTIICAELDSBEYPARDAETSIIOGNN TCEoSMTPLDEATYE 40 2 2 2 2 20 20 2 zn 2 2 2 2 2 zn 20 20 22 2om 236 20m 3 36 20 20 2 2 20 20 --~ 54a `Company Sanitized. Doesnot contain TSCA CBI 9H0-D25a4y25G;avSeubgeehSroundiyciTnoxRiactistywithOne.Generation Reproduction Evaluations DuPont-11418 ~~ INDIVIDUAL CLINICAL OBSERVATIONS IN P1A MALE RATS GROUP: III-1 DOSE: 10 MG/KG/DAY ADL EER oBseRvATION FOIBRSSETRVDEADY LOaBSSTERDVAEYD 7011 SPARCERPIUPTIICAELDSBEYPADREASTIIGONN TCEOSMTPLDEATYE 40 670315 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN TCEOSMTPLDEATYE 40 670319 PSRAECPRUITFIIACLEDSBEYPADREASTIIGONN CTEOSMTPLDEATYE 40 670323 SZRAECPRUIRFIIACLEDSBEYPADREASTIIGONN TCEOSMTPLEDTAEY 40 670128 PSRAECPRUITFIIACLEDSBEYPADREASTIIGONN CTOEMSPTLDEATYE 40 70331 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN CTOBMSPTLDEATYE 40 = FS 2 2 20 20 2 2 2 zn 2 25 --~ --~ Company Sanitized. Does not contain TSCA C81 H25425; Subchvonic Toxicity 90.Dsy Gavage Study in RatswithOneGeneration Reproduction Evaluations Dupont-11418 ~~ INDIVIDUAL CLINICAL OBSERVATIONS IN FIA MALE RATS GROUP: v-1 DOSE: 100 MG/KG/DAY ADL NoEER oBsERvATION OFIBRSSETRVDEADY OLABSSTERVDEADY 670335 SPARCERPIUFTIICAELDSBEYPARDAETSIIOGNN CTOEMSPTLEDTAEY 40 70339 PSARCERPIUFTIICAELDSBEYPADREASTIIGONN CTOBMSPTLEDTAEY 40 70340 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN CTEOSMTPLDEATYE 40 670347 `FSRAECFRUITFIIACLEDSBEYPADREASTIIGONN CTEOSMTPLDEATYE 40 670351 SPARCERPIUFSIICAELDSBEYEADREASTIIGONN CToEuSPTLDEATYE 40 670155 SPARCERUITFIIACLEDSBEYPADREASTIIGONN CTOEMSPTLDEATYE 40 670355 SPARCERFIUFTIICAELDSBEYPADREASTIIGONN CTOEMSPTLDEATYE 40 --~ 670361 PSARCERPIUFTIICAELDSBEYPARDAETSIIOGNN CTOEMSPTLEDTASY 40 670367 PSARCERPIUFTIICAELDSBEYPADREASTIIGONN CTEOSMTPLEDTAEY 40 70371 PSRAECGRUISFIIACLEDSBEYPADREASTIIGONN CTOEMSPTLDEATYE 40 670175 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN CTOEMSPTLDEATYE 40 670379 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN CTOEMSPTLEDTAEY 40 670382 PSARCERRIUFTIICAELDSBEYPADREASTIIGONN CTEOSMTPLDEATYE 40 670387 SPRAECPRUITFIIACLEDSBEYPADREASTIIGONN TCEOSMTPLDEATYE 40 2 2 2 2 2 = 1 1 2s 2 20 20 20 20 2s 2 2 2 2 =n zn 2 zn 2 2 2 2 = --~ 1346 `Company Sanitized. Does not contain TSCA CBI 9H02-5D4a2y5G:avSaugbechSrtoundiyciTnoRxaictistywithOneGeneration Reproduction Evaluations DuPont-11418 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN FIA MALE RATS GROUP: U-1 DOSE: 100 MG/KG/DAY ANDO NMBER oBsERvATION FOBISRESRTVEDDAY OLBASSETRVDEADY. 70391 SPARCERPIUFTIIACLEDSBEYPADRAETSIIOGNN CTEOSMTPLDEATYE 40 670395 ASSLAROCEPRREIUCFTIIICAAELDBOSTEBHPYADRFEARSTOIINGOTNNPACTWEOISMSTP)LDEATYE 40 670399 FSARCERPIUFTIICAELDSBEYPADREASTIIGONN TCEOSMTPLDEATYE 40 670403 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN TCEOSMTPLDEATYE 40 70407 APLROEPPEUCTIIAAL30STEHPAFRRAOTNITONPACMOIMSP)LETE SACRIFICED BY DESIGN TEST DAY 40 2 2 "2 2o3 m 20 20 20 20 2a 20m --~ --_ 547 Company Sanitized.DoesnotconTtSaCAiCBnI 9H0-.2D5a4y25G;avSaugbeeShrtoundiyc TinoRxaitcsitwyith OnGee-nerationReproduction Evaluations -- INDIVIDUAL CLINICAL OBSERVATIONS IN FIA MALE RATS GROUP: VII-L DOSE: 1000 MG/KG/DAY Dupont-11418 ADO NBER oBsERATION GFBISRESTRVDEADY OLABSSTERVDEADY 670411 SPARCERPIUFTIICAELDSBEYPADREASTIIOGNN TCOEMSPTLEDTAEY 40 670015 SSARCERFIUFTIICAELDSBEYPADREASTIIGONN TCBOSMTPLEDTAEY 40 670415 SPARCERPIUFTIICAELDSBEYPADREMSTIIGONN TCEOSMTPLEDTAEY 40 70623 SEARCERPIUFTIICAELDSBEYPADREASTIIGONN TCEOSMTPLEDTAEY 40 670427 PSRAECPRUITFIIACLEDSBEYPADREASTIIGONN TCEOSMTPLDEATYE 40 670431 PSRAECPRUITFIIACLEDSBEYPADREASTIIGONN TCEoSPTLEDTAEY 40 $7035 SPRAECPRUITFIIACLEDSBEYPADREASTIIGONN TCEOSMTPLEDTAEY 40 ~~ 67039 SSRAECFRUITFIIACLEDSBEYPADREASTIIGONN CTEOSMTPLDEATYE 40 670443 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN CTOEMSPTLEDTAEY 40 70448 PSARCERPIUFTIICAELDSBEYPARDAESTIIGONN CToEMSPTLEDTAEY 40 70452 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN TCoEMSpTLEDnAeY 40 670456 PSARCERFIUFTIICAELDSBEYPADREASTIIGONN TCEOSMTPLEDTAEY 40 70659 SPRAECPRUITFIIACLEDSBEYPADREASTIIGONN CTEOSMTPLDEATYE 40 670463 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN CTOEMSPTLDEATYE 40 2 2 2 2 2 2 20 20 2 2 2 = 20 20 2 n 2 2. 2 2 2 2 5 zn 2s 2s = =n ~ Ti `Company Sanitized. Does not contain TSCA CBI 0H--2D5a4y25G;aSvuabgcehrSonticiuTnodRniacytistywithOGneenerationReproduction Evaluations Dupont. 11418 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN PIA HALE RATS GROUP: VIZ-L DOSE: 1000 MG/KG/DAY an EE OBSERVATION OFBISRESRTVEDDAY OLBaSSETRVDEADY. 670467 PSARCERPIUFTIICAELDSEBPYADREASTIIGONN 7C8OSMTPLDEATYE 40 670471 PSRAECPRUITFIIACLEDSBEYPADREASTIIGONN CTOEMSPTLDEATYE 40 670475 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN CTOEMSPTLDEATYE 40 670479 PSARCERFIUFTIICAELDSBEYPADREASTIIGONN TCEOSMTPLDEATYE 40 70483 SPARCERPIUFTIICAELDSBEYARDAETSIIOGNN TCEOSMTPLDEATYE 40 20 20 2 =n = = 2 2 2 2 --_ --~ Te `Company Sanitzed. Doosnotcontain TSCA CBI 0H--2D5a4y25G;avSaugbcehSvtoundiyc iTnoRnaictistywithOneGeneration Reprodsction Evaluations DuPont11418 --~ INDIVIDUAL CLINICAL OBSERVATIONS IN FIA FEMALE RATS RoR: II-1 DOSE: 0 MG/KG/DAY amo wosE onsERVATION OFIBRSSETRVDEADY OLBASSETRVDEADY. 670487 `VSAAGCIRNIAFLICPEADTBEYNCDYESCIOGMNPLTEETSET DAY 40 670451 VSAAGCIRNIAFLICEpDATBEYNCYDEcSIoGwNLETTEEST DAY 40 670455 VSAACGRIINFAILCEBDATBEYNCDYESCIoGwNprTETEEST DAY 40 670459 SVAACGRIINFAILCEpDATBEYNCDYESCIOGMNPLTEETSET DAY 40 670503 VSAACGRIINFAILCEpDATBEYNCYDECSoIwGpNLETTESET DAY 40 670507 SVAACGRIINFAILCEBDATBEYNCDYECSoIwGpNLETETSET DAY 40 70511 SVAACGRIINFAILCEPDATBEYNCDYESCIOGMNPLETETSET DAY 40 670515 VSAAGCIRNIAFLICEBDATEBNYCYDESCIOGMNPLETETSET DAY 40 670519 vSAAGCmRuIAFLICEeDTmBNYCYDECSoIuGpNLETTEEST DAY 40 670523 vSaAGCnRuIaFLICEeDATBEYNCDYECSOIMGPNLETTEEST DAY 40 670527 vSAaCaRmIuFLICEpDaTBmYNCDYESCIOGMNPLTEETSET DAY 40 670530 vSAaCGRmIuPLICEpaDTmBNYCYDESCIOGMNPLTETEEST DAY 40 670514 SVAACGRIINFAILCEPDATBEYNCDYESCIOGMNPLTEETST DAY 40 70538 VSAAGCIRNIAFLICEPDATEBNYCYDECSOIMGPNLETTEEST DAY 40 1 1 1 u un un n un n 12 0 10 1 12 fn 1 0 10 0 10 n 2 5 s 3 5 n un ~~ 1350Company Sanitized. Donote contsain TSCA CBI 9H-02.5D4a2y5G:avSaugbcehSitoundiyciTnonRiactistywith One-Genersion Reproduction Evaluations DuPont. 11418 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN FIA FEMALE RATS GROUP: 11-1 DOSE: 0 MG/KG/DAY ADL OER oBssRvATION OFBISRESRTVEDDAY LOABSSTERDVAEYD 670541 vSAaCGRhIuFLICEPDATBEYNCYDEScIoGwNrLTeBtSeT DAY 40 670545 vSAaCGRhIuFLICEPDATBEYNCDYEScIoGwNLeTTEeST DAY 40 70se SvAaCGRmIuFLICEeDTEBNYCYDEScIOGwNPLTEETSET DAY 40 670553 vSAaCGRmIuFLICEeDTEBNYCYDEScIoGwNLeTTEEST DAY 40 670557 SvaAACGRnIUFAILCEPDaTBEYNCDYESCIOGWNPLTEETSET DAY 40 5 s 10 10 1 10 n 12 un n TI Company Saniized. Does not containTSCA CBI 9H02-5D4a2y5:GavSaubgeehSronticaiTnodRxiacytistywith One GenerationReproduction Evaluations DuPont-11418 --~ INDIVIDUAL CLINICAL OBSERVATIONS IN FIA FEMALE RATS GRowP: TU-1 DOSE: 10 MG/KG/DAY noenwoNoemen opseRvATION 0862 vSaAGCTRWIAFLICEPDATEBNYCDYESCIOGMNPLETTEEST DAY 40 70566 VSAAGCHRUIAFLICEPDATBEYNCDYECSOIMGPNLETTEEST DAY 40 070 SvAaCGRmIuFLICEPDATBENYCYDECSOIMGPNLETTEEST DAY 40 670571 SvAAGCTRNIAFLICEPDATBEYNCDYECSoIWGPNLETTEEST DAY 40 60575 SVAAGCIRNIAFLICEPDATBEYNCDYEcSoIwGpNLeTTEEST DAY 40 70579 VSAAGCDRWIAPLICEPDATBEYNCDYESCIOGMNPLTEETEST DAY 40 7083 vSaAGCIRWIAPLICEPDATBEYNCYDECSOIMGPNLETTEEST DAY 40 --_ 70587 vSaAGCIRWIAPLICEpDREBEYNCDYECSOIMGPNLETTEEST DAY 40 0591 ANVLLAOOGPPIEBNCCAIILAApBBAOOTTTEHHNCFFYRROOCNNOTTMP1LBEA3WT((ESS)) SACRIFICED BY DESIGN TEST DAY 0 670597 uSaAGCTRWIAPLICEpDATEBYNCYDECSOIMGPNLETTEEST DAY 40 670601 vSAAGCHRWIAPLICEpDA7BEYNCDYECSOIMGPNLETTEEST DAY 40 0605 vEAAGCIRWIAPLICEPDATBEYNCYDESCIOGMNPLTEETEST DAY 40 670609 VSAAGCIRNIAFLICEPDRTBEYNCYDESCIOGMNPLTEETSET DAY 40 FGiaRssEtRvDEADY 10 n un s 2 2 1 n 33n6 2 un un 5 LOABSSTERVDEADY 10 12 un s 12 12 12 1 10m fom 2 u un 5 --~ - Ts Company Sanitized. Does not contain TSCA CBI H902-5D4a2y5:GavSaugbecShtroundiyciTnonRiactistywithOneGeneration Reproduction Evaluations INDIVIDUAL CLINICAL OBSERVATIONS IN FIA FEVALE RATS GRouP: Iv-1 DOSE: 10 MG/KG/DAY Ames wes oasERVATION FOIBRSSETRVEDDAY 670613 vSAAGCIRWIAFLICEPDATEBYNCYDECSOIMGPNLETTEEST DAY 40 5 670617 VSAAGCDRWIAFLICEPDATEBYNCYDECSOIMGPNLETTEESE DAY 40 10 670621 SvaAGChRuIAFLICEPDATBENYCDYECSOIMGPNLETTEEST DAY 40 1 670625 SvAACGRHIUFLICEZDATBEYNCDYECSOIMGPNLETETSET DAY 40 2 0628 SvAaCGRmIuFLICEpDTEBNYCYDECSOIMGPNLETTEEST DAY 40 10 60632 SvAaCGRnIuFLICEpADmEBNYCYDESCIOGMNPLETETSET DAY 40 s Dupont-11418 LOABSSTERDVAEYD s 10 u 2 0 s --~ Ts `Company Sanitized. Doesnot contain TSCA CBI 0F--2D5a42y5G;avaSgeubehSrtoundiyc TinoxRiactistwyithOneGeneration Reproduction Evaluations Dupont 11418 ~~ INDIVIDUAL CLINICAL OBSERVATIONS IN PIA FEMALE RATS GROUP: VI-1 DOSE: 100 MG/KG/DAY ANDOL NOHBER oBsERvATION OFBISRESRTVEDDAY AOBSSEERDVAEYD 670636 SvAaCcRmIuFLICEeDmEBNYCYDECSoIuGpNLETTEEST DAY 40 670640 `VSAAGCIRNIAFLICEEADTBEYNCDYECSOIMGPNLETETSET DAY 40 670644 VSAAGCIRNIAFLICEmDATBENYCDYECSIOGMNPLETTESET DAY 40 6064s VSAAGCIRWIAFLICEpDATBEYNCDYECSOIMGPNLETTEEST DAY 40 670805 vSAAGCIRWIAFLICEPDaTBENYCDYESCIOGMNPLETTEEST DAY 40 0653 vSaAGCIRWIAFLICEpDavBEYNCDYECSOIMGPNLETTEEST DAY 40 70657 SvAaCoRmIuFLICEeDaTBmYNCDYESCIoGdNpLTEETSeT DAY 40 --_~ 670861 VSAAGCIRNIAFLICEPDATEBNYCDYECSOIMGPNLETTEEST DAY 40 60662 VSAAGCIRNIAFLICEpDATBEYNCDYESCIOGMNPLTEBTSET DAY 40 670666 SvaAGCIRWIAFLICEPDATBEYNCDYECSOIMGPNLTEETSET DAY 40 670670 VSAACGRIINFAILCEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 60678 vSaAGCmRuIAFILCEeDaTBEYNCYDEcSoIwGpNLeTTESET DAY 40 670679 VSAAGCIRNIAFLICEPDATBEYNCDYECSIOGMNPLETETSET DAY 40 670681 VSAAGCIRNIAFLICEmDATBEYNCDYESCIOGMNPLTEBTSET DAY 40 1s 15 2 12 n 5 5 5 10 10 n 2 n n n n n n 2 12 5 . un n 10 10 3 5 --_ Ise Company Sanitized. Does notcontain TSCA CBI H0.-2D54a2y5:GavSaugbceShrtoundiyc iTnoxRiactistywith OneGeneration Reproduction Evaluations DuPont 11418 ~ THDIVIDUML CLINICAL OBSERVATIONS IN FIA FEMALE RATS GROUP: VI-1 DOSE: 100 MG/KG/DAY nL WE oBsERvATION OPBISRESTRVEDDAY OLBASSTERVDEADY 670685 SvAaCGRIIuFAILCEPDATBEYNCDYECSOIMGPNLETTEEST DAY 40 670689 VEANGODPWHATLHALPMAUTSENRCIYGHCTOMPELYEE(TSE) SACRIPICED BY DESIGN TEST DAY 40 70653 SvAACGRDIWFAILCEPDaTBEYNCYDECSOIMGPNLETTEEST DAY 40 67067 VSAACGRIINFAILCEPDATBEYNCYDECSIOGMNPLETTEEST DAY 40 670701 VSAAGCIRNIAFLICEPDATBEYNCYDESCIOGMNPLETTEEST DAY 40 un u 3i 10m n n un n 2 12 --~ ~~ Tis Company Sanitized. Doesnotcontain TSCA CBI H25425:Subchronic Tosicity 90-Day Gevage Study in Ras withOneGeneration Reproduction Evaluations DuPont-11418 --~ INDIVIDUAL CLINICAL OBSERVATIONS IN FIA FEMALE RATS GROUP: VIII-L DOSE: 1000 MG/KG/DAY Mn ome oBsERvATION OFBISRESRTVEDDAY OLABSSTERDVEYD 670705 VSAAGCIRNIAFLICEPDATBENYCDYESCIOGMNPLTEETSET DAY 40 670709 v`SaAGCDRWIAFLICZEADTBEYNCDYESCIOGMNPLTEETSET DAY 40 670713 SvAaCoRhIuFLICEeDammBwYcyDEScIoGwNpLTeTEsST DAY 40 670717 vSAaCGRDIWFLICEpDaTBEYNCDYECSOIMGPNLETTEEST DAY 40 670721 vSAACGRIIAFLICEPDATBEYNCDYECSOIMGPNLETTEEST DAY 40 70725 VSAAGCIRNIAFLICEPDATBEYNCDYECSOIMGPNLETTEEST DAY 40 670729 vSAAGCIRWIAFLICEmDaTBEYNCDYECSOIMGPNLETTEEST DAY 40 --~ 0733 SvAaCGRIIuFLICEpDAmBEYNCDYECSOIMGPNLETTEEST DAY 40 670737 SvAaCcRhIuFLICEpDATBEYNCDYECSOIMGPNLTEETSET DAY 40 670760 VSAACGRIIWFAILCEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 6707s vSaAGCDRUIAFILCEeDavBaYNcDyEcSoIwGeNreTrEsST DAY 40 670748 SvAaCGRDIuFAILCEBDATBEYNCDYECSoIwGpNLETTEEST DAY 40 0751 vSaAGCIRWIAFLICEmDaTBEYNCDYESCIOGMNPLETETSET DAY 40 670755 SvAaCGRIINFAILCEBDaTBEYNCDYEcSIoGwNprTaErSET DAY 40 2 2 u u un un n 2 1 1 2 2 10 10 u u 10 10 u n is 15 5 5 n un n n ~~ "Ise `CompanySanitized. Doesnot conTtSaCAiCn8 9H-02.5D4a2y5G:avSaugbecShtoiyc TinoxRiactistywithOGneeneration Reproduction Evaluations Dupont 11418 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN FIA FEMALE RATS GROUP: VITI-1 DOSE: 1000 MG/KG/DAY ANDO KOER oBseRvATION FOIBRSSETRVEDDAY OLABSSTERVDEADY 670759 SVAAGCIRWIAFLICEPDATBEYNCDYECSOIMGPNLETTEEST DAY 40 670763 SVAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLETTEEST DAY 40 70767 SVAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLETTEEST DAY 40 670771 SVAACGRIINFAILCEpDATBEYNCDYESCIoGNNPLETTEEST DAY 40 670775 VSAAGCIRNIAFLICEPDATBEYNCYDECSoIMGPNLETTEEST DAY 40 2 12 3 5 Fl Bn un un u 1 ~~ --~ TT `Company Sanitzed. Does notcontain TSCA CBI 9102-5D4a2y5G:avSaubgcehSrtonuidcy iTnoxRiactistywith One-Generation Reproduction Evaluations --~ DuPont 11418 --~ APPENDIX KK INDIVIDUAL BODY WEIGHTS OF Fy MALE AND FEMALE RATS -- 158 CompanySanitized. Doesnot conTtSaCAiCBnI 0H-25D4a2y5G:avSaubgcehSrtoundiyc iTnorRiactistywith One-Generation Reproduction Evaluations DuPont. 11418 ~ INDIVIDUAL BODY WEIGHTS OF F; MALE AND FEMALE RATS EXPLANATORY NOTES Note Test Day 1 = Postnatal Day 21 Abbreviations - = NoDaw ~ BE `Company Sanitized. Does not contain TSCA CBI 0H.-2D5a42y5G:avSaugbecSktoundiyc TinoxRiactistywithOneGeneration Reproduction Evaluations Dupont11418 --~ INDIVIDU. AL BODY WEIGHTS (5) OF FIA MALE RAYS Grove: 1-1 Dos: wo/KO/DAY onoTnevsst: An NomER s7700118560 8s7700119946 887700720040 &s7r002m0z8 777000222221006 &7700222382 &7700214316 87700224455 8770022573 1 5 5 2 36 Sse0s1 esless 1mms2g e2s1l0.0 aLess $Je37 Dsilss 21054323 2220s03 39589020 $S5033 mmllzs l1esa 2231s 33s3s3i92 G8i0 mmoelsl 11s702 22806.06 3406a1l8s 7S3i8s $06 1s8l0a els 1i8s6e3 1959 225:4302 263 33318340 d0s. SGl0e 110074030 11673438 2234905213 23958313 G.l4 1a7m0i1 11sesls 2263080i1 833887 SBilee smelzs Issea l 2a1m9iis 33348710 sSo5l3e 1m0l7e 1a8e7s iasmlao s35z08 -- --~ Th60Company Sanitized. Doesnotcontain TSCA CBI 'F9-02-5D4a2y5G;avSaugbeehSrtoundiyciTnoRxaitcistwyithOne-GeneratonReproduction Evaluations ~ INDIVIDUAL BODY WEIGHTS (g) OF FIA MALE RATS Grove: 111-1 DOSE: 10 MG/KG/DAY onoTaErss: AGL EER 81700226615 7877000222776519 78700228735 87700223817 887700229959 18700330073 700331151. 1100332139 s70o32m8 1 o 15 2 36 GG46 G3 mmi2 mals wmeera 13s amreils 2601 3361s0 120 SS57065 dToorasz a17e0s4 22a411ss 331622 SB6530 Gz wTemz awmia 220200as a2wsa sr 163 2213 3007 7S0a1 583 1al3s sols mle3ss lea saoelss zee 3229s 331 S1s 4 0a2a3 mss 11603s usa 22:5916s 200 33830s0 38a G82z lmoemz l1e5s2s3 226s0a070 3as022l2s GGs1 27 lmoiar 1a 1we2 10s 2aaslss aslo 33ss sis --~ DuPont 11418 --~ Te CompanySanitized. Does not contain TSCA CBI 9H02.5D4a2y5;GaSvuabgcehrSotnuidcy iTnoxRiactistywith One-Generation Reproduction Evaluations Dupont11418 ~ INDIVIDUAL BODY WEIGHTS (5) OF FIA MALS RATS Grove: -1 DOSE: 100 MG/KG/DAY owoTaBvSsT: ATL EER 87700113359 887700334470 88770033551 7700336539 87700337617 887700337758 7700338827 7700339915 47700349053 70407 1 5 5 2 36 7s6e0.s els 1s2a7s3 1200 110206 1s97 22s182lss 2s8ls 43242as 369.3 $se5z @3 1l2o0 sls 11s0 a3 m21s sy 3s3sos JGlss 740 Dnese 134 2113s7 19300 2296525 2603 asess 3695 GGllso 11023s7 s1el3s 222682i 3sa6i1s Sssi i10l90es 1193171 zaiel 3e9n sS031 G3 1e0r8s1 ala 112e222 212 2a3a6slis els 33473 a8l2 0 ss 0m0l1s 1a6190 a2sna0 4173 $0 als as 270 390. -- --_ *Data inadvertently no recorded for est day36. Te `Company Sanitized. Doesnotcontain TSCA C81 9F0--2D54a2y5G;aSvuabgchSrtoundiyiTnoxRiactistywithOne GenerationReproduction Evaluations INDIVIDUAL B0DY WEIGHTS (5) OF FIA MALE RATS - nove: vIz-1 DoE: 1000 MO/XG/DAY onnetsst: 1 s 1s 2 3 An NomER 77000151 70019 Sseeias $23 we0nss7 ses m13s.s2 as 2aamalos mls 3d3ea3T 263.4 7700412273 70431 S3570 Fo zrliss als 1102s ama 2e6l0lo4 2s 34607431 ssi 877700044433398 G320 Gi mim2o dea l19m7ss 12 2206714.08 2s 33m86 32a 667700045828 670455. 3S8604 WI nsesls ae 1as.s3o ae 2s29e08 2esls 3a6m6i1s1 dea 667700446539 70467 S$98078 305 Iosai.s4 ama a13es ass 22001830 als 13a64lkse 7877000444777515 3 aG3s 1m10e3ms5 aammleies 22aea30 3ms7i60e3 s70083 87 ills mss ae 3673 --_ Dupont 11418 --~ J 6 CompanySanitized.Doesnot conTtSaCAiCBnI 9F0-.2D5e4y25G:avSaugbecShrtoundiyc iTnoRxaitcistwyithOne GenerationReproductionEvaluations --~ INDIVIDUAL BODY WEIGHTS (9) OF FiA FEMALE RATS - = Grove: 11-1 Dose: 0 G/KG/DAY owonTEeSsT: 1 5523 nos NomER E770006817 E&770066955 87700550037 7700551115 &a7r00552135 87700552370 7700553348 887700554451 87700555439 &70857 3s900.80 2s s76r.s2 amos 1w1i0.z5 mia a14m9i.s0 201 a18s0.l2 2691 S012 Ss sssesn mio ewliss mwa ammliss sis ammoaisze GG6a S05 160124 san l1e1a2s 17 211830 melo 22569274 2a 0Se7lo Seis 0a72.4 sels 115s3s mez s20s4a0 ama 22s3sl2e 2160 SS56588 Sle sseass sss 1ass 102 asaear amy 2de:s22 289 G233%5 amsweaaeo s1myms 1ed8e6zs3 2aa3s60s6 S58 saa aes ens aauls -- DuPont-11418 --~ : -_-- CH CompanySanitized.DoesnotcontTSaCAiCnBI 9F0L-2D54a2y5G: SaubevhSrtouandiycigTnoRxaeitcsitwyithOneGeneration Reproduction Evaluations ~ INDIVIDUAL BODY WEIGHTS (g) OF FIA FEMALE RATS Rove: 1v-1 DOSE: 10 MG/KG/DAY onoTnEeSsT: Am NBER asrr00ss6626 7a700557701 &&77008s7755 &7700558873 78700859917 ss7100660018 6s7700660153 7700661271 887700662258 70632 1 5 1s 2 36 GSe4o 0s8lss 110sa 1e9l.d4 2205826 GSi5d 0s0l7a 1e0e2s 1s7sso 22809041 $1s 0seaa mmoess eelle m22s1s1 SS7o026 Sis esseilss 108s 1li9s0 Les 1i5e3s 1802 11770003s 2361 ossls S61 dsoarss 10a e13n0s sea 1assso 17s 221:3921738s s3e0s 1T1ee0n 1a9lz3 a1ess0l3s a2oas SSlass 1e0s2 mss 11377a mls 110s0 20a 22200063 247 eGlzs 1103 11e52l33 ssllss 22:62069 ~~ Dupont11418 --~ I6s CompanySanitized. DoesnotcontTSaCAiCnBI 9F0--2D54a2y5G:avSuabgcehSrtourdiycTionxRiactistywith One-GenerationReproductionEvaluations ~ INDIVIDUAL BODY WEIGHTS (5) OF PIA FEMALE RATS ----Group: vI-1 DOSE: 100 MG/KG/DAY onoTREtSsT: 1 8 1s 2 i ANDOL NBER ssr70066306 7700668445 887700665835 887700666517 7s700666662 87700667704 &7700667851 8&7700668855 70693 67700760917 7e3s3s &1 m7e6s2 1065 amsess iso i1e1ss sla a18u0.s9 237 GS71020 S05 seerlss 1m0s7 ses 12 1e8l3o a22n42 1801 2363 3&13 &3 asmas mio aemiae ae mmos 12 2aessa2 ss $Soss Se7 lIooss sa e1:2o. mils i13m0s1 ao e2220s50is0 SSles ssi2 asemz se wweusz we wimsa am aaasi 26d &G076 aslaere eamnis 2a0ss 2a1us S50130 as0seiss smeae 1a4l6e3 2.0 --~ Dupont-11418 --_ a-- r * Data inadvertently not recordedfo test day 36. i366 Company Sanitized. Does not contain TSCA CBI 9F0-.2D5a4y25G;avSaugbechSrtoundiyciTnoRniacsitwyithOne-Generation Reproduction Evaluations ~~ INDIVIDUAL 20DY WEIGHTS (g) OF FIA PENALE RATS Grove: VIII DOSE: 1000 G/KG/DAY owoTnEeSsT: Amos NomER 7700770059. s7o07m1?3 7700772281 67700772393 &100773070 7E07706788 E7&70077555 7&700776539 7700771611 sm 1 5123 : Ss0e3s S15 asaenl 7sle l1e7m.s0 mes 21602.00 wir 21588173 ama SS52055 G3 sssass sez 112112 ws eelss mln 2oa1s2i2s 2:2 8Se0l3e Sos msmzs se 2amsl wm asesz els 2l7e4a7s 1894 S$o0s6 Gs 0s7i4 1203 1mes0s7 1es3 e10l1a4 2034 2200522 2081 GS623 S68 1 sma mi a1maas mea meiilmaos 2s2eslss S$e0l5e S94 0s0s0ns ss mlealsos maa lesao6 assis 225239091 ane G3 aslo esis isan 24907 --~ DuPont11418 --~ 67 Company Sanitized. Donotecontsain TSCA CBI 9H02-5D4a2y5:GavSaugbeckSotnuidyc iTnonRiacistywith One-Generation Reproduction Evaluations ~~ Dupont 11418 ~~ APPENDIX LL INDIVIDUAL BODY WEIGHT GAINS OF Fy MALE AND FEMALE RATS -- FE 1368 ---------- Company Sanitized. Does not contain TSCA CBI H-25425: Subehronic Toxicity 90 DayGavageStuy Rats withOneGenerationReproduction Evausions Done11419 ~~ INDIVIDUAL BODY WEIGHT GAINS OF F; MALE AND FEMALE RATS EXPLANATORY NOTES Note Test Day 1 = Postnatal Day 21 Abbreviation - = NoDaa ~ e-- ee --------Th-- e: -------- Company Sanitized. Doss not contain TSCA CBI 9F0--2D5a42y5G;avSaugbecShtoundiyciTnoRxaitcsitwyithOne GenerationReproduction Evaluations ~~ INDIVIDUAL B0DY WEIGHT GAINS (5) OF PIA MALE RATS e Groves : 1-1 DOSE: MG/KG/DAY onoTneEsST 18 sas as 22-6 1-36 Ano NomER 7700119806 7700119964 87877000222000480 s1100221126 7700222240 s7700223228 7700220316 77002244s3 8&7700213573 d3ae $1 ms3a nr mseaa ms s12l1o8 1a 2377s.0 ase i$s2 505 ealze 3 seonloo een mwalms mus a2m0es os GWBasa 1 esslas tsena eas uwenls 320094 mz 29 $954 Wr mslae elo ne1a 760 naselno sls 1da4d 38s BG7o0 23 3 es an msaie ern anmaln 1asls 2n9e3d3 3063 i$eo 3% smias als eessln sus wmeelna sao 2ze1d 4 20s 21 lh els umes 22 Dupont-11418 ~~ - TI370`CompanySanitized. Doesnotcontain TSCAC81 9F-02-5D4a2y5G:avSaubgcehSrtoundiyc iTnoxRiactistyith One-Generaion Reproduction Evaluations Dupo 11418 ~ INDIVIDUAL BODY WEIGHT GAINS (g) OF FIA MALE RATS _ rove: 111- -1 DOSE: 10 MG/KG/- DAY -- owoTaErSsT: 1 eas 1522 23 1436 ADL OER a7700226615 arr00221618 &7700221755 78700228873 58777000222999158 78700330073 7S0730118 7700331203 7s700333218 6a5. S05 seeso slo s6ee.z4 153 auss.lo 330060.51 uals 3 @8a 35 sserz Sls meaz ea aam7i sms 3308s6 2sie 3365 32 sGl0a 70 eessso sel2 mmelsa isla 22m10l9s 30s7 4433 5 aelsso ql selas mis 1w0os as aamme nels 8S0o7s 22 eses fos eselno aassin ewe 3200026.0 milo dPeo 59% emo3 ell loellz eels ealmss m3 maiin 2m $2.0 sez 12a 12s am ~~ -- -_ Bre Company Sanitized. Does not contain TSCA CBI 9205.4Da2y5;GavSaugbecShtoundiycTionxRiactistywithOne-Generetion ction Evaluations Dupo 11418 ~ INDIVIDUAL B0DY WEIGHT GAINS (g) OF FIA MALE RATS t ieee Groe ve: v-1 ee DOSe E: 100 MG/KG/DAY s owaTvEsST: 1s eas 152 23 1% ToL NER 85777000333343509 7100335471 87700335559 7700336637 a7r00337715 s&7700338725 87700338971 87700339959 78700440073 S5o.l8s S000 @ sez gsr e59e.s9 es uelne sls a26s9ls 2994 $G5s 4 msleso ee ssaas eo slalls mle a23e9s7 men Ss06 SU msaos ls sslssa ers 0si8l6o ms 230750.00 assis 1 Ws fs aslsa fa emliss ma onreo2 ner 2amiss an WS0o7 $5 emails aa emias el 11a930e3 a30lsieo amo 3S6I als sselss es seeers sss 1a3n ea0p30d 9 $6 se ma wa awa ~~ --_ *-- rDaetea f-- or inter-- val coul-- d motb-- ecalculated:data inadvectndy not recorded for test day 36 ----To-- Teerste -- --eeet Company Sanitized. Donotecontsain TSCA CBI 9F-02-5D4a2y5;GavSaugbcehSrtoundiyc TinoxRitcistywithOne.Genero Reproduction Evaluators ~ INDIVIDUAL B0DY WEIGHT GAINS (3) OF FIA MALE RATS Group: viz-1 DOSE: 1000 MG/KG/DAY a- owaTvEsST: 1s eas 1522 2236 136 Am OE 1700015 87700041239 7700843217 8770083395 68770004803 7700445526 7700466535 7700407617 7700407759 Et i 382 53 essss sso s63e.z8 a 11203823 ss 32604.s0 ain $S0e5 Bl mmias ssl meilss soo lwzl mal 3a0 ze SS0l0o We eellss Eo esesa wn aallao siz a30s8l0 267 0 S50 3 lelss als e7e0s4 ses 1u6e3s nes 33067s7 2930 3al8e Bis saleo sels soesn esis assll s 12003 2am1a7n 28s B8E34 eJso sla eesas 70h 117a als 3a26e0 0k 0 HW? ea pe mle -- DuPon 11418 ~~ - Tn `CompanySanitized. Dossnotcontain TSCA CBI 9H02.5D4a2y5G;avSaugbecShtroundiyciTnoxRiactistwyithOneGenerationReproduction Evaluations ~ INDIVIDUAL BODY WEIGHT GAINS (g) OF FIA FEMALE RATS Rove: 11-1 DOSE: 0 MG/KG/DAY onaTvEsST: NTL NBER 867700449817 887700449958 887700550073 87700551115 887700552135 87700552370 s58777000855033184 887700550055 887700858573 18 eas 1522 2236 13 367206 a0 e3s3 sla 2m9s3 ss mal2e 110s2 elo 1943 330610 300 s4el7s 31 msuas ms sselss 1176630 als els 3Lsi 83 ewzl alo asshs es wsenr massls sla iss 53 37 ssah als oownws m2 wsse assaas sels asa 3l0l0sis malles see a3zz aa slolss 118s5 sie 1193 4 3a 307 adellos a7 amllss es amlss 1166a s so amas 3 mls owls aa ase --~ DuPont11418 --~ TI `CompanySaitized. DoesnotcontTSaCAiCnBI 9H02D54a2y5G;avSaugbecShtroundiyciTonxRiacistwyithOne-Generation Reproduction Evaluations Dupont11418 ~ INDIVIDUAL BODY WEIGHT GAINS (5) OF FIA FEMALE RATS i Rove: 1-1 DOSE: 10 M3/KG/DAY -- onoTaErSsT: esas 1522 2-36 13 ANDHAL SOMBER sa77005s662e 7700557701 7700557755 &&7700558837 &87700859917 887700660015 8s7700660153 78700661271 7a&77000666232528 w36s2 wmalzs 243 sesz 1s60e a0o 3205 wasas aed mwls 3003 sslshaasme sas ami 333a 22 welse aso aosaia 3s aelesn a1s2s0o 167 127 iwoo 37 wdois se zmilee zee sslsy mimee als m1 2$322 397 apsza az a 361 za a sa a1s4as 3a 10 W30e% 005 aaemss ss ma3s als aso3r 1aase sls 2093 $$78 bswo ewiss sseo aamal _ --~ EZ CompanySanitized. Doesnot conTtSaCAiCnBI 9H0:-2D5a4y25G:avSaugbeeShtoundiyciTnoxRiactistwyithOneGenerationReproduction Evaluations -- INDIVIDUAL BODY WEIGHT GAINS (3) OF PIA FEVALE RATS Grove: vI-1 DOSE: 100 MG/KG/DAY owaTvEsST: nL NOR s87700864306 887700884458 887700884593 87700886517 s87700886626 887700887704 87700888719 887700888895 87700883373 s70701 18 eas 1522 236 136 32217 eas 21s.2s msl0s 1sess d39l0s8 aml1s e37s3a s4e3n aaees 33sa 3s slsl a2 m2l1ss wa sselzs 1assus sls 1s 3768 as7l aaweas ssszs 112e12 $#24 aelns mml7s sallss 116m00 3241 wsios 2 saa sl 1166070 3390070 asl2s wsass s2l3 a1n7is G30l1s essoas 2a7 aasl a18s3a8 3 2902 a36s3s maeas wa se=a ~ DuPont-11418 ~ ---------- Data for interval could notbecalculated; data inadvertently no recordedfo est day 36. 3%. CompanySanitized. DoesnotcontTSaCAiCnBI H25425: SubchronicToxicity 50-DayGavageStudyinRats with One GenerationReproduction Evaluations ~ INDIVIDUAL BODY WEIGHT GAINS (g) OF FIA FRALE RATS Rovp: vIII-1 DOSE: 1000 4O/KG/DAY onaTvEsST: TOL NOHBER 7700770098 7700771173 7700772251 &7700772383 s70o74m0 7700778488 777000177535591 7100776637 77007715 18 eas 1522 2s 1436 3S9i.a3 mls 3s9s 1 2s5s0 aes 2s9l.s3 1123sd asia no $33s65 adel7s ass ea0o17 mellas 113m06 sols 159 2#33 ae3a masie nsiia 1200s0 S#058 34 saz3 os 2m6l7s ms s2lss i1s0i0s6 als 1523 230641 35 d3e sea 3aeh sis selalr 113290s 2 29ls m3 3258 wma1 mmoo seles 1m2s0 2350 awsleo o2a3siss ssees 116s0a.38 7 sie ass sss ssid DuPont 11418 --~ 7 `CompanySanitized. Does not conTtSaCAiCnBI 9F-02.5D4a2y5;GavSaugbcehSrtoundiyc iTnoxRiactistywithOneGenerationReproduction Evaluations --~ DuPont 11418 -- APPENDIX MM INDIVIDUAL FOOD CONSUMPTION OF Fy MALE ANDFEMALERATS -- _ 7 Company Sanitized. Does not contain TSCA CBI 9H0--2D54a2y5G;avSaugbecShrtoundiyc iTnoRxaitcsitwyithOne-GenerationReproductionEvaluations ~~ INDIVIDUAL FOOD CONSUMPTION (g/day) BY FIA MALE RATS Grove: 1-1 DOSE: 0 MG/KG/DAY onoTaExSsT: mos ER 7700119806 87700119586 7787000222000880 &i70012126 8&7700222200 7700223228 777000222443516 &7700214553 &70287 8 sas 52 236 136 #s3s nls o1m6a3 ms 22119 27 2359 wa 2169.9 3 Bnllea Ble 1ls2 20s mmlasz 2s 2alss m7 2a2u0ss 2800 #nl7s 2w3a 2s0z4 ewlad 2a6s1 mL1I no 2Il3s ma 2al0s ae 0 ass 06 a22s3s mnllss Ba 2105s5 23 s2l1s an 2mis s joa 2al0s an 3 15s5 pmlss 1ls oamsee mo 2m11 22 a2:0s 20s 0n5i omwlas wm3i 21ah a14s --~ DuPonc11418 --~ BECH Company Sanitized.DoesnotconTtSaCAiCBnI 9F0--2D5a4y2G5avSaugbcehSrtondiyciToRxaitcsitwyithOne-GeRenproedurcioan Etvaliuaotionns ~~ TNDIVIDUAL FOOD CONSUMPTION (g/day) BY FIA YALE RATS Rove: 133-1 DOSE: 10 MG/KG/DAY DuPont11418 onaTvess: ADL NOHBER 7sr00226651 75700227615 7700227795 78700228873 87700229915 7700320939 S7700033311057. 7700332139 7&700333218 18 eas 15-22 22:3 1-36 nmles Blo oawlss aa a2e6s8 oma 020383 ms 267 20 LB54l80 allllsss 2oeals2iss a33s00is0a 222044000 w1i0 Wi: m1i2s owls aml0s 252 2m63s 2a3z m4: L1I7 132 1ow3ls als 2ms2 26s a2l1s al 0am2l as BLlios io malws aa a2s3lso ma 2953 wiz aoz:s 263 1wse 123 aa17 101 20 ss 3mlio ze3 2s6a0 xe is aa es 30 280 --_ --~ - T580Company Sanitized. Does not contain TSCA CBI F-25425: Subchronic 90-Day Gavage Study TinoxRiaciistywithOGneenerationReproduction Evaluations --~ INDIVIDUAL FOOD CONSUMPTION (3/day) BY FIA MALE RATS arovR: v-1 DoSE: 100 MG/KG/DAY owaTvEsST: Anos NBER s87700333398 78700338407 7700335315 887700333653 87700337617 7700337785 87700338827 888777000333999155 &87700000073 eels 1522 23 136 mW2i nls 0mos1w 3ow5s 26s 2s6l6a 26 2a1s2e 27 mnlos Le waiess 00 a19n7 ass 22872 7 210920 Bi B1530 wi allaar oma a1e7s ms 2a6a 200 2wsa 2a 113%5 ealess 2m5o3 1 263 2200 WBlio mi m2ow027 228s3 wa o2w9l0s3 ess a24a3 al iBls Wwe melss en mmaa7s 222s sz 22000 als fWee a1las nmaa wsoss 2263 DuPont 11418 TE`Company Sanitized. Doesnot contain TSCA Cal 9H02.5D4a2y5;GavSaugbcehSvtoundiyc iTnoxRiaclistywith One-Generation Reproduction Evaluations ~ -_ INDIVIDUAL POD CONSUMPTION (5/day) BY FIA MALE RATS eaRoevp: vII-1 DOSE: 1000 MG/KG/DAY onaTvesst: 1s eas 1522 236 1% Rm OBER s0a0ns e70a0ss 8777000000323157 887700414339 ssm700eussz 8707105169 s8777000441766137 7700447795 70883 LmEa 1002 wmsas les omwss 20 lssa mo a2l0s3 181 w1i5 Blo owwsn ms 2oassis 20 oomna 23 aalssi ml WLoa nls smo o m3 a28z1 212 awsas mo a3e2 196 nB7o0 nls 2 ma 2 ozzeees 252 woas 2200 2m: 1u0r0s ne eosn ma m2i0s mls aaess es 123030 aa mnllss 12 wawlis 11 2as0l3o zea wal 0 22 26a3 B20 m7 sl 3 zz DuPont 11418 --~ -_ The Company Sanitized. Doesnot containTSCA CBI 25425: Subchronic Tonicity 90.DayGavageStudy inRaswithOneGenerationReproduction Evaluations ~~ INDIVIDUAL FOOD CONSUMPTION (g/day) BY FiA FEMALE RATS Rove: 11-1 DOSE: 0 MG/KG/DAY owoTnEvSsT: mL ym 7877000008985571 87700059053 667700531017 76700881155 777000855732307 87700553348 87700554415 &7700554553 70557 18 eas as 236 136 Bm51s.08 01162172 am1ll6sss 211548.2s4 211306.099 1u0i08 1353 11as 2e0l0ss 1166ss 2u3s ewss 1w9o0 aml2y 1 ss mwlas 1owsls 2 1s a1l8s0 1186)8 0m271o 11w66z21 92 ow0lss 1l18e00z2 111661s4s 1 21 1w6a3 ealss 1a6lss s1lds wsos a1s6lso a1l3s s1l9s0 116130 muss a1s1 o13w aalmsa 11s3 nz as ws ans 15 --~ Dupont 11418 --~ -- T= CompanySanitized. Does not conTtSaCAiCnBI 9H0.-2D54a2y5G:aSvuabgeehSrtoundiyciTnoxRiactistwyithOne-Generation Reproduction Evaluations --~ INDIVIDUAL FOOD CONSUMPTION (g/day) BY PIA FEMALE RATS _ Group: 1-1 D0SE: 10 MG/KG/DAY owoaTxSsT: 18 eas sz 23 1036 Am OEE sr700s36826 7100857710 887700557759 888777000858988137 887700650917 7700850058 777000666211137 78700662285 870632 fwoa ie 1a8n1s 143 mmso ws 118971 22 162s ss 0174 pe 11s2 pa m20os wy 21080s asa 1168a0 ao 02001 ma 1lss 111sss an2lls 1no7na3d aWlso B28 a1l7sa ame 0 10 101 11a s 193 11161s0ss MBee Ba 11s22 10s 1sss 2007 aaeess 201 11s74 se aS3 ew mls ie 13s aslss aes 2aas oasis 01ss aus BE 13 Blo a els --~ DuPont 11418 J ThE Company Sanitized. Doesnotcontain TSCA C8 9H02.5D4a2y5G:avSaugbeeShtruodnyiiTnoRxaitcsitwyithOeGenerationReproduction Evaluations -- INDIVIDUAL 200D CONSUMPTION (g/day) BY FIA FRE RATS aroue: vi-1 sos: 100 wo/KG/DAY DuPont11418 onamvesen: anos EER 666777000666483046 7&77000666665553 &s070605368712 E170006667874s0 EeE1000667585:5 EE7110006698973 Evol w0mi4owmwses e11s5a HWWiiooowool8Ws33 0 wmmss5 32W7hoabsmns Bw1sh2 BWWEaeooapasa mm17sb Ww wsroioNmooEr 1laass $3S35o adWslh Lmmirne 2 de 202 = wamisaa aw1el0d unbnrs aualebss mmwba2 1oual 0wwesaa audeedss wBmssow1aness uwwsos wm1snl to wa --~ TEs `Company Saniized. Does not contin TSCA CBI 9F0--2D5a4y25G:avSaugbechSrtoundiyciTnoRxaictistwyithOne-GenerationReproductionEvaluations --~ INDIVIDUAL FOOD CONSUMPTION (g/day) BY FIA FEMALE RATS Group: viz DOSE: 1000 MG/KG/DAY owDTaExSsT: 1s sas as: 236 136 amos NomER 7700770098 wnor 21032a 2106015 2 182 210502 s7007m173 w7r 1ws3 1i8e7s 1 172 615a3 s7700772218 70720 2 nie ws i1s6lse mle 1a8e3s mls 11928 als a11u632s &8777000777343307 Lnwoes amalleae 1e6z7 20 a 184 23 1a5s0 194 &7700774848 870751 wniae 4 o1as0is 1sls w1ias 20 s1l8as 20 1s17lsss 78700773555 70763 wDoilse ns l15e1 wiz aesso els a1l0s 14 116573 172 7700777617 nmza 1mhl ualles 1280as 11624 0m nis 20 ls 1s 187 Dupont 11418 186 Company Sanitized. Donotecontsain TSCA Cal 1.25425; Subchronic Toxicity 90-Day Gavage Study in Rals with One-Generation Reproduction Evaluations --~ Dupont 11418 pe APPENDIX NN INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - FI ADULTS -- ES Company Sanitized. 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Tos fgCpoo ga EB 8 Igsz 8 pid yal gE: id igi you EE : 155g60:1 SfiEfReS 1}: 3 FI Fg 3: 25 1rd fy FE 18g I: if be EEE 8 iim EEe fggiBE ~8 id iiinin Comsat. srs mcm rsa eo hi ; pod 1 fp of irifEg ggi EigRfE sro # IgR g 58 i; 0 iii H gidEbE esEH 2 gr Hg i|Ie.[I I S1ifE 1E 8ic 10 18; gop p 8 igiir 8 Ii E of & j EEE 3: arbi id 53 shi H it oH52 gIggL IE gp pl ;i oiff g :: 2 ; 15 fio : i id | hg! ! iEiH d E ; a fg 11 i ji EEg:if : RPL ri 3 i if frag id CE lihh i ie Peer fi ~ )' ny Sanitized. Does not contain TS( ii ij | IH EL rg i] I 8 Pe ~~ ny iflg id itil if 11 HH V |11;ie g! id fllli lH 4 Seer ll isg bRrE EaHdEil | simms ~t ; Pd :Polid I::[I i gf 0 hl 1 fiylief J| i gilis 38 5i 11; ih Cd bli i ss aaa 1% ~ 3549 43 G PinL g H id ~ iyy 3 3 : |fo|io:g| i : | 8 EE || HEil ii | gi 1 i izH H 14lI |i; 'ShiTeRoE 25| Epi . H pih lin ~ 83 =8 i or IR ti Company anted. 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Codd ;i HE1 ERY 1Hob Hi ~ liLi:d HBiflEr li, 1 HE fgd ft |jC : i Pela dE |; Pasoled ii DaeHiE i eSe i Petes a 3 | | | nt. tom 5A i 1 i: Po i1 iL in iif8 8 TRE fi g 1 ~ liood El 2s 3 f5: ilfl EBR E s 88 fg iE, ois 11 fHaElL fa: 18 of FEPpLiLiEiEoa i a lid no ~ gl CH 3 gs 0EEEEZ CE :i : Compa Sts, tsrtsr 3c 3 fpf % i8 : 1i Poei hTr8p,i ii h g i 3 gg 18: la ~ HliEt] pe58 013 : gst s 88 fC ' HdEi0 8 P2i8g 5et4 HE feo ie gJ ot: jiE;Yi]f i Pier 13 244 53 gSgigigf FssF a i 8g i [I 1I i : ii:f EI oi i gg 58 jLE M ToReE : oid HIE pei 0 588 5s : 1. HEF g{l I i i3 Fa:d: 1% fk EES 2 qf i; ff 1 0,eiii id 2% 8 gg g wows gE 5 23 i2 sPlaEgiier og ~ % 3 oge PE BEEeRrEeEkE Companys. oectcoran sonGa bo og i iI : i zi g id ifgt, & g . 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