Document 0gbwOG3QajRV24owwL8g6Y3zV

fr den Aufsichtsbezirk Westfalen ,>efl' .orst ehendes Akt enzeichen angeben) Der St aat liche Gewerbearzt , 463 Bochum, Marienpiet z 2 Mr.Robert A.Kehoe, M .D . Professor of Occupt.Med. College of Medicine Eden und Bethesda Ave. Cincinnati, Ohio 45219 1 j X1.Bochum 'fX- rv Fernruf 60575 - 79 Post scheckkont o Dort mund 32799 Bear Professor Kehoe! Many Thanks for your kind letter of 15 dec. 1970. A copy of the final communique'of the Amsterdam-conference is added. In this paper you may see the recommended limit values being for ALA 10 mg/1 and for 6PTJ 300^/ug/l. The limits should not be exceeded but for short periods. As they are only slightly higher, than upper normal limits (M+3s = 8 .mg ALA and 250 yug CPU/l) the matter will lead to extreme difficulties in factory inspection. A report on the Amsterdam- conference including the "final Paper' 'published in Arbeitsmed.Sozialmed. Arbeitshygiene 4, 56,1969 With best wishes for the new year Sincerely yours / 7<w// ftersystryy T)i2yglcj?a;feo3.g^"'" ...-.~ A great wei&h of possible biccfc* parameters- provide Insight into the- effects of lead on biological systems* 'ilelatiyely fey of them have been used up to now frequently enough, to provide data for their use as- biolog*'permissible limits* fpidemiolcgicai study should be promoted* i$- possible a s& international basis* In those parameters that have a - -relatively high speaificity . '' * * relatively high sensitivity . in regard to .. - beginning exposure - current exposure .and long-term exposure - post exposure* the cybernetic approach should be promoted in the study of industrial toxicology; it may increase the understanding of functional behaviour of biological systems* the combined increase of A M and G? in urin and P*P* in erythrocytes is highly specific for the action of lead* unnoe/ot of poisoning . Poisoning io present if physical-, mental and/or social veil being has been impaired; it supposes the presence of clini cal symptche and signso Pho diagnosis of lead poisoning should be based upon well informed clinical judgement; the use of the term poisoning should be restricted to the above definition* ' One should distinguish, between parameters indicating absorpv ticii and parameters indicating response* She-response can fee classified into three phases* ' acceptable s exposure below permissible limits ~ excessive; exposure beyond permissible limits6 where . ~ poisoning may occur " dangerous; Exposure beyond permissible limits*- where poisoning is likely to. occur* ' i HE 001S372 ./-icdicai experts should stud,7 the establishment of' the re lationship feetvreds. exposure absorption - response! they should lay down acceptable mdical, criteria.: he practica bility of this In different societies' and cultures 'may depend on socio-economic factors'and.ether namsdicsl criteria, but should always be considered in the light of expert medical advice . . . where is sufficient correlation between, certain parameters, to permit calculation of interrelationships and hence permissible limits* , . Chronic effects, 1;. Present evidence suggest that industrial standards which prevent cases of lead prisoning.- even after many 2-ears of exposure, also prevent long term.sequelae* Further, under standing of this problem say follow from epidemiological studies in groups of workers under less satisfactory send?. tionss partisulary by following up hnovni cases of poisoning* fra*sii'BAvii uf .es'saen 1, In establishing permissible limits for lead in air most .reliance''should- be given to data bases upon personal sampling Results should bo qualified by particle siso and composition of the dust* . '* Re If absorption is to be acceptable the blood lead concen tration should be below* TO yUg/100 ral which will prevent I any untoward effect of lead* This corresponds to values for; I ill I Fell a * 10 iag/I /V130 ^ug/X- CHI ,~J 300 yUg/l ` Pbin air 150 yug/cr% 3o fhese values .are solely guides* Because the wide can fidcnee limits of the calculations no undue emphasis should be placed upon a single parameter* ;-* here tnere is adequate medical supervision above mentioned slight!;/ exceeded for short periods* .-o -- ove cu-aoicaea values only apply for a population at work not being-treated with chelates* . " - Kff 0 0 1 S 3 7 3