Document 0gVZ19j0GDLQJYJbg4861Zedn
WW rWAAgiRsFom,INwShTsIcTOUNTsEI, INC.
AT3
aang: ae rea or Se a Reportsaresubmfi oct liet ntseonda confident names ial basis. No ey Le To referentcoe the Ao ra ho mt work, the results or to the Institute tino tor any form
REPORT
AR226-0127
Sample: 1-165
ARE No. 5011023
Date Received: 1-13-75
Submitted by:
S7S.ti. C5.oPmpteaonngyutnnesota
Testing requested: skin Trritation
Eye Irritation
Conclusion: Under the conditions specified the product has a primary
aye tetpectivaty for amwaches eves skin irritation score of zero and eye irrltation scores of 23.67,
23.67, 21.67, 13.50 and 3.33 at 1, 24, 48, 72 hours and seven
The product is not irritating to the skin and is irritating to the eye.
Report approved by:
Signed
Be
and for WARF Institute, Inc.
Date: January 28, 1975
elleessLseryn
Chief Pathologist/Toxicologist
001785 J
WI WARF INSTITUTE, INC. MADISON, WISCONSIN
Sample: T-1166
Primary Skin Irritation:
WARF No. 5011023
Method: Albino rabbits were used for this work. They were housed in individual screen bottom cages and fed water and rabbit chow ad libitum. The hair was clipped from the back and flanks of the animal. Five tenths of one milliliter
Of test material was placed in intimate contact with. the skin on prepared test sites (abraded and intact), and covered
with gauze patch and tape to maintain contact with the skin. After a 24 hour contact period, the coverings were removed
aS0nkdintthIheerrsic2t4aalteainobdnel7o2swc.ohroeurrReraedaidnignsgsweruesedsakteondeAtgearimninege t35hemnariinsary and the degree of erythema and edema was recordedaccording
Results: aNnuimmbaelr AbFafe2d4 UHnoaurbsrided
Abrade7d2 HOomusrsbaSsd
Average
13
i53
a11nosnitoetsedreiardrinteatsiaocnive
6
Primary skin irritation score: 0 Scale for Evaluation of Skin Reaction
Erythema and Eschar Formation Score EdemaFormation
Score
Slight erythema Defined erythema
MSoedeveserrcsahtaererytfcoohremsmaeatvieortneo ec1riygthhtema Score equals sun of erythema
Skin irritation index equals
1
Slight edema (barely
2
perceptible)
1
3
4
MDoeedfeifrnieandtieteeeddeemrmaiasi(ne(gad)rgeeas 2
Semvroearrieesedtedhea1mnam.m1)(mrma)ised
3
4
and edema readings.
average of 24 and 72 hour scores.
001786
`WlMWADAIRSOFN,IWNISsTCIOTNUEITNE, INC.
Sample: 7-166
Eye Irritation:
WARE No. 5011023
Method: Adult albino rabbits of the New Zealand White
-
variety were placed in a collar such that the animals could
not rub their eyes. One-tenth of a milliliter (0.1 gm for
solids) of test substance was instilled in one eye, the
other untreated eye served as a control. A series of six
athlebintoestrambabtitesriawlabvaussedreafdoracsecaocrhdisnugssctaoncteh:e s"ehmotecoefastcianoknittso for damage to
conjunctivae
the
at 1,
cornea,
24, 48,
iris
72
and
hours
the
and
bulbar
seven
and palpebral
days after
Gye instillation: Any residus of he ress meremiii ois accumulated discharge are flushed from the eye each time
they are scored.
Administration:
Concentration of test sample:
Diluent or solvent: none Special washing: none
as submitted
Results:
.
RNaebmbeirt ORCCoIrneAaTER Irie EdensCoenjhuencsteiviayerehars
13
1i 4: o5 2:
2:
2i
f1our 43
i1
2:
[5
32
32
2;
:5
20
02
0
32
23
23
31 2h4ours 31
5: 1 hwosurs :233;
1 hour eye irritation score: 23.67
1i
4:
50
32
32
i1
2;
00
32
:2
02
02
05
32
2:
1 4 0 2 24 hour eye irritation score: :23.67
313i 3::2 5050
2:33
22; 3
ii1ii
48 hour eye irritation score: 21.67
:2 23 23
1 I13i 1
001787 .
WIMWADAIRSOFN,IWNISSTCIOTNUSITNE, INC.
Sample: 7-116
Eye Irritation: (continued)
WARE No.
5011023
Results:
MReambbbeirt 31
rnows 543
6
331 days 1
5 6
OpiSCTorenreaAres 12 32 511 o3i
2
2
Iris FduessCCohnejmunscstiisvaeDischaras
00
32
00
00
000
::;
000
03:
0
2
0
0
72 hour eye irritation score: 13.50
000 000 000
200
100
020
00o
5
o
5
[J
0
0
0
0
0
1
2
0
0
0
0
7 ay eye irritation score: 3.33
C01788
Wl AWAIRSF,INWSITSICTONUSTIEN, INC. RepoGrtisvareens,ubmnietwtsedrtoecslisent1s oaniarcoPnfuidbesntiSalhboosuis.neNnoreyfereencetao the wwoirk,,hthee erseslu,ltstort1o tthhee Insltiituete iinnaannyfoforr
REPORT
Sample: T-1166
WARF No. 5011023 Date Received: 1-13-75
Submitted by:
2S.i CE.omptaonnyg
St. Paul, Minnesota
Testing requested:
Eve Teritation
Conclusion:
| asncdoresseUvneodnferd7a.ty3h3se, croe6.ns6dp7ie,tcitoi6n.v0se0l,yspe2fco.r6i7fieevadensdthwzeaesrhopersoadtuacb1,tles2h4a,s4 sve Zenit e48y,e 7i2rrhiotuartsion aeCnxedpsosz"uevrraeoshaaendtda1f,etyae2r4',ia'rr43i3,6tats1i2eocnohnodusrcssorroeansndd.otfsee?v8e.6n7,dav1e1'.3s3e,spa7i.i33r,ver4y.67tor
The product is irritating to the eye.
}
Report approved by:
Signed
e
ina for WARE Institute, Tne.
Date: January 28, 1975
Chie PA atnote osistd /mowr ieiogies
01789
--_--
WlMWADARISFON,IWNISSTCIOTNUTTINE, INC.
Sample: 7-166
WARE No. 5011023
Eye Irritation:
Method: Adult albino rabbits of the New Zealand White variety were placed in a collar such that the animals could not rub their eyes. One-tenth of a milliliter (0.1 gm for solids) of test substance was instilled in one eye, the
other untreated eye served as a centres. A serive of shree albino rabbits was used for each substance. The reaction to
the test material was read according to the scale of scoring
Cfoornjudnacmtaigveactoatthe1, Co3r4,nea4;8, ir72ishaonudrsthaendbeslebvaern SaanydepaAflbpeerbear eye instillation. Any residue of the test material and hey are scores, accumulated discharge are flushed from the eye each time
Administration:
Diluent or solvent: none Concentration of test sample: as submitted
Special washing:
Results:
oe erase eyes washed with 300 ml. of distilled
water over a two minute period, after
.
RaNobmbbietr OpECeoirinyeaAfes Iris
1
000
1
2
0
0
0
hour 3
0
I]
o
ChFednoessmCoencjuincrtbivraescarse
1
0
1
1
2
1
2
2
1
Paours 21
00 00 003 3:2 710 7i0 1 hour eye irritation score: 7.33
hwours 132
231
hours 3
24 hour eye irritation score: 6.67
000 800 800 332
i?0
10
48 hour eye irritation score: 6.00
00
00
00
2i
0
00
0
0
0
1
0
0
72 hour eye irritation score: 2.67
01790
Wl WARF INSTITUITNEC,.
Sample: 71166
WARE No. 5011023
Eye Irritation: (continued)
Resuite:
RNianbbbeirt 13
days 3
OpaCcoirtnyeaEres Iris HonesCCohnjeumnccsttisvaebiEchErg
no noted irritation
all readings negative
7 day eye irritation score: 0
c0r1791
'
WI WARF INSTITUTE, INC.
Sample: 7-116
WARE No. 5011023
Bye Irritation:
Method: Adult albino rabbits of the New Zealand White
variety were placed in a collar such that the animals could
not rub their eyes. One-tenth of a milliliter (0.1 gm for
atD slohlbeiirdnrso)urnatofbrbeaittteessdtveossyuebsutsseaedna rcveefdorwaasseacaihnE csotsniutblrsloces lad.ncien.AonsTe"eoTrhsieaevyeer,oenaofcttahietiohnroeeseo
for damage to the cornea, iris and the bulbar and palpebral
conjunctivae at 1, 24, 48, 72 hours and seven days after
eye instillation. Any residue of the test material and
accumulated discharge are flushed from the eye each time they are scored.
Administration:
RE Concentration of test sample: as submitted
Special washing: aeyteesra woavsehreidawibtehg m3i0n0nsutmle. poerfioddi:stiflileerd
Results:
.
RNoambbbeirt OpEeCtotryneaAFem iris FodnessCConhjeumnecsttievaeDTschargs
11
00 0o 00 1i
23
11
hour 3
0
0
0
2
2
1
1 hour eye irritation score: 8.67
P2aours 133
00 000 0o 332
133
331
24 hour eye irritation score: 11.33
1
000 2
3
0
48
2
0
0
0
2
1
0
hours 3
0
0
0
3
1
1
231
hours 3
48 hour eye irritation score: 7.33
0o 05 00 2:
00
0o
0
0
J
2
1
0
72 hour eye irritation score: 4.67
001792
WN WARF INSTITUTINEC,. MADISON, WISCONSIN
Sample: 17-1166 Eye Irritation: (continued)
WARE No. 5011023
Results:
NRuambbbeirt 721
days 3
OpaCcoirtnyeaAres Iris RednessConChjeumnocstiisvaeDischarge
no noted irritation
all readings negative
7 day eye irritation score: 0
001792