Document 0gJ4LqKpRzRxkrN03LQOXmj1b

To T T Misti a s worts F T hv DH 0K a. v ]/n\y ! <1* Cf^ ^ ^ u*j 4, 1976 ttoofcod Is rs^vt cf tlM SMtlac of tho MC, YJj^l 0 , Tntwwi, M D. J<P Att Qixootor 631025 ;v 4x44 '*if; r ^ u Ji..-*,' W Urn pwyoM of tt lwdttt wu to ropcrt tt* wirrwrt rtrtiu of HS; ip--idead riM>it projects on TOf d to itt >now flm for future saudOHWk of sta^jr of padfelo effort of Ton. fTnaaftAI that HXdcMkftMM Baton*!. toodollr Is artatlo. tto tttMl mm pwter 1b rafcblto tkn la site auK rin* a lew tullaaa f aditetdla mm eboorood at 29Q0|n Iml la to tho afli la aULtlia to tho KM mpoarn. Trtlalrt that the study deco act lead to the aood gm great wnnoam for tho progaest taili wcrldaf la pled* Am KM lonOa era not high- Mai kap la dad lev looelodeec art nwaaTlTy ipiut togrtoggifloitgr tam f pnadWllty rf *|IW asian effect at a arltloal pedal la (d*r* 15-35) Wear* tho wma known oho 1 pregnant. of KM la artaeln. TOR at low tatoke loeel (lose Am lppa), aojorftr of tho aatohollto la iiwrtil la wlaej d high IntAe M (SOOppa or am) aaiodtr of TOt In eamtod la mired air. 0 631026 r*~w studies ahcv daprojsion cf eUrtathloa* levels la tlw Itvir correlate very mil '-,dth tuner (ecglemrctniO Incidence In Maltoai study. Ugfests possible does response level fcr YUM iaay ha In am of 3Dcga. uestica vaa rvlaad as tc possibility <-f use cf high doaeo of glutathione as a prapi^l/ccLs against V ;M tocde offeet however this is speculative and nsads staty. The nooct stop in the Betabolln study should ba to look at V-1K or nstoholito tzlndlag with IS! and 3S.-t and also tc study in vitro vb*rt the prlaery dateodiication reactions are. Tj X l SopHwar - Industrial Biotegt .'ierisved artlnwl stndy procedure aid interia reports cf result 3. prepr-ring final report, -feggested take close lock nt survival rates fcr arpoaed anlnals sad note dos^tlne relatioa In ncrtelity data. shcvs that the lneldonee of toecrr In tlw anlanlj 1* dose -related ultfc 30-50% ocearrlx^ at the fOops level. Incidence rsta In controls is 4-5%. Peak of flcae response In terns of percent of tas*<r incldecsae is at the 2G0pj level. rr 1 7 JchMt^a - lev jjggdcel Reported --a tvw studios for mtageiietle effect of 7CK. jzlaal studies (rats only) showed no unusual laddenee cf abncneal ells at three levels af exposure (50, 300 and 25C0pp) as ec^&red to ecsitrcla. Study of cell* free bisnsn exposed to 718 at levels of l-5pj nnd l-25ppo shoved no Increase In cfcroaoeouel eherrationa es cce^Jered to controls. Reported cae study In literature cf htaen exposure at "high levels' (epedfla level not reported) t&lck 'showed higher aberration rates. Ore--riteii on study done by leHkoff, chewing Increased aberrations In YCH workers. B*s*9vsr it Jchnstoa stated this study vas net fully understood hr c*>researehsrs tdio had reviewed the data. ar MIHm Qeffsr - Stanford ________ (fnnearly with Ttaberabau-OcopSE' 4Soalatee1 Reviewed current status of sjztdMdolagy study of 708 worker*. Study data aov In final st^ns of analysis. Date on 9000 workers In T? plants. states Oaneer Incidence ante to be acre related to teratlc-u of esmlcroaecl rather then latcnay period and that increasing 631027 ru-yrLnaa. level of sxpo.-raro ocrrelatee vdtb irwre&aing Bcrtaiity rtt. Flas! report will be aeon able la 3-4 mV? ate sr. .Attars rereanfe .fit unniber tf studies wadsrvajr ** planned - laalods oerly d^gnooia test awlaatloPj role of i muHwQrtgf^T ps^jooua, nstabollaa (different ajiprah tfasa Dee sto^p), electron sdoroaoogy cf tiswoa, troabaent rntbodclo^. /-resent fwadlng f*"^ Sectional de&ear Inrtltata is 32.7 sillicm/year tart use la Halted to existing mUbadolccp. that Interested aaaibair cre^?aai~ fned otter 0 of L studies at coat of 2C0,CCC/year plag 44X',CCO/y^>ar fear coatlr^oacies* I'Afcrastlca will bo east to ccaposioe for review *5 euGnortt. 'onsidar cm cr grout robber tbwa antret. ui j etalags ca uso of aonay to allow 3 si L to bow flasibilltT'fbr ose cf funds la variooa raoeereh prccheta. tscbaieel panel rscceeaends 1-year grant with review t end of o&s Tear sad reconsideration for sxfcaftsicn* ftfttapnrt taktottfl* ^rtr Dev Jbmiaal seeds *133,000 for additional 7r vtaay. TD1 Amid d ell ffessoa of preseat fcatabollss atn^y. TJH Tsotaical Panel reom--ends funding for ooa year. tfctt feftrta fter dUooaalon the panel daelded to table pleas for tbia sfeidy for the present, ftp* rseaneidar In future. >reas releeaa of reports sad dtseundca at meting f TaAnieal Panel, Panel anted net to safe* press release. Panal approved M2 inwtlnu. a letter covering e presses report < iC --TCM steadies to appropriate gevansaeoi agenda*. Or Torfealsoa (Dow , Qedrmn of Tbehnlasl Penal, authorised to review and approve this letter. So speeiile dets ms set far next meting of the Techrsioel Panel. ft 7 Aep 631028