Document 0g57L4QBOYMoX6QkyJnqJN4On

Corporate Occupaiaaa Mcine S3M eTneE, BEuildLing Y220-305 AR126-0470 5173 5060 Fn SIM > An Evidemiotogic Mortaity Study of Employees at the Chemolite Pant "This isthe original retrospective cohort mortality reportof employees at the Chemolite Plant in Cottage Grove, Minnesota conducted by Schuman and Mandelofthe University ofMinnesota. Summary results were cited by Ubel et al (se study # 1). A review of personnel records indicated there were 3688 workers employed for a least 6 months between 1947 and 1978. Vital status was ascertained through 1978. The results of this analysis revealed no significant findings. The authors reported that a number of SMR's, particularly forthe cancers, did exceed the null value but were not statistically significant. Therefore they recommended continued updating ofthe vital statusof this cohort. tis important to note that line by line abstraction of work history cards was not done in the original study; rather only the date of first employment at Chemie, last date of employment at Chemolite, and period ofemployment in the Chemical Divisionof the Chemolite plant were abstracted. Individual jobs and departments were not abstracted. This original data file was subsequently used for two updates (see studies #3 and #4). However, in the ongoing retrospective cohort mortality study ofthis Cottage Grove workforce (scheduled for completion by September 2000), the entire work history record has been abstracted and will be used to construct an exposure matrix related to perfluorooctanoic acid 03126 WO BESTCOPYAVAII ABLE ofhnTaEppltedpaeeastotaocpttcheMoCrhteaslaliittyeStFuadnye February, 1580 Lreoonarrd H. Schuman, 1.0. + 373sc3c Epidentolony Associates c0a127 An Eptdentologtc Mortality Study of Esployees at the Chenolite Plant tncroduction A retrospective cohort mortality seudy of esployees at the Chemolite Plane in Cottage Grove, Minnesota vas conducted. ALL employees who had worked at least six sonche at the Plant vere included in the study. The baste objectives of the study vere twofold: 1. To determine vhether the mortality experience of employees at the Chesolite Plant vas significantly different from that expected in population group of this demographic composition. 2. To decernine vhether the morcalicy expertence of employees fn the Cheteal Division of the Chemclite Plant vas significantly different fron that expected. Methods ALL employee records for all divisions of the Chesolite Plant are stored in a central location (Personnel Office). The personnel recordkeeping syscen has been designed so that complece rcords have been maintained on all enployees who ever worked at the Chemolite Plant. These records are also nsintained for employees vho transfer vithin the JN Corporation. Thus, tn constructing the study cohort ft vas assumed that a cosplete roster could be assesbled of all enployees vho ever worked at the Chemolite Plant since its opentng 10 1947. A careful review of the personnel records indicated that a total of 4218 hat been employed at Chemolite for some period of time since 1947. Of these, 1688 vere employed for at least 6 months. This group comprised 03128 Sl ' 3 BEST COPY AVAIABLE che haste cohort for study. Information vas sbatraceed fron persomel records. In sany tne acances number of records exited for & given employee and these records wre stored fn different aress in the personnel office. Nevertheless, 411 sources of information vere ascertained and the appropriace daca sbscracted. For each individual the folloving information vas coded onto Fortran costa sheets: Eaployee number ase sarens Telephone umber Soctal securtey nusber sex Birthdate Marital acatus Date of first eoployment at Chemolite Dace of lsc employment at Chemolte Period of eaployment in the Chentcal Division Status (current, retired, deceased, disabled, latdotf, Cranstersed terminated, reason not seated and returned to school) Date of death (4 noted on record) Ares teanatferted to (11 noted on record) For each of the 3688 employees, two computer cards vere punched with the information mentioned shove. : A computer tape Listing the nase, soctal security nuaber and birchdace of G03129 11 but the current esployees vas deveioped and sent to the Social Security Administration (SSA) to ascertain those individuals vho had dhe during the period of study (1947 - 1928). A otal of 180 deaths vere ascertained froo SSA records. For each each the state of last residence, the state of last employment, of the state from vhich the benefit vas filed along vith the date of death was listed. This fnformation vas used to obtain a copy of the deach cereificate for ech decedent. Unfortunately, since the most vical piece of inforsation - state in Vhich the death occurred = vas not pro- vied by the SSA, acquisition for all death cercificates vas a foratdsble cask. For those deaths for vhich a death cerciticate vas not available from the state of last residence, the state of last esployment, of the state from ubich the benefit vas filed, & search vas made in Minnesota using - the Winnesota Health Department's comulative sfcrofiche death index : 1962 = 1978 and the death records prior to 1962. Information (name, social security number, birthdate, date of death) on all deaths for which the death certificate vas not acquired by any of the sbove mentioned methods vas sent to the Wisconsin Health Department to determine if a death certificate vas on file in their records. UEt1zing these procedures, 168 of the 180 (33.3%) death certificates vere acquired. Inforaation on the remaining tvelve vith a request for a copy of the death certificate vas sent to every state health department except Ninnesota, Wisconsin and New York. Minnesota and Uisconsin vere excluded since heir records had already been reviewed. New York vas exclude since they require the borough fn which the death occurred to : 03130 BESTCOPY AVAIIABLE secortala the death cereiticate. Hovevets 1 an of the tueive desch cere : Clientes emai outstanding atcer & search by all other state heateh deparcnente, then an access wild be ade to access New Tork vical records. The death certificates vere coded by 4 professions] nesslopist ace cording othe Internacional Classi ication of Diseases (1..0.), Elghih Revision. ALL fnforsscton Sn che cause of desth section of che dench cecciticate vas coded, This included the snberiping <a of death, fn mediate cavie of durch, conditions related to the dmmebiate cause of death (se(erTe8 0 on the desch cercificate an "an a consequence of" ax dur 16"), 104 other signdfScant condictons. These coten slong ith the ntividuat's none and sncial security masher (i factlicace inking hese daca co che main (130 vere trasaferrad ono Torcean codion sheets and keypunched. In addition co taeacitying the deatha, SA reporced that for 485 members of the study cohort oo benetien vere cursencly being said. Tain mesnc chat : 3 ssh could cer cophactently scace vhecher chase Sndsvicunta vere dead or Alive. Woveves, published reports (see for exseple Hans, N. nd Machanen, 5. 5. Occup Wed, 21, 745, 1978) have seated that che sscercatonent of more City by S90 fa victuntly complete and hac addicional follow up on (nn eividusia for whom no tnformation 1a available from SSA records ie unneccensary. Nevertheless, 4 crer to be abaclutely certain that all deans were ascertained, every affort vas sade through extensive tracing feces Cn Incermine the curtent statun of these 485 unaccounted for scudy meehern. The SEAR OF Virtually S11 of these people vas decerained in chin vay. ath of Ansiyats The nacho of anaiyais 1s bused an + comparison of the chrerved to expected Geach Fates apectfic for cause, ape, ine, sex snd race. The 03121 BEST COPY AVAILABLE 7 and proportional mortality, Conp. Biosed. Res., 7, 325-332, 1974. or int +11 Qs - aff vrs upper Liste = ub = (B11 = Use) + 1.96VTB) 12 2 Only those vho worked ac Chesolite for six or more months (3,688) vere : 03132 fable 1. EptdentologJtoely,Mor1t97a8li=tyDSetcuedaydero,f C1h97e3solite Plant Records Abscracted Nusber Studied Nusber of Deaths Death Certificates Analyzed wus 3,608 180 (6.51) 18 063133 able 2. Results of WCaalvesse,-SpeCchtetsicclitNeorPelaalnitc.y (A3na6lyosnttshe) Couse of Death 140 - naitgnant Neoplasas 000 - ALL Infective and Pacasicic Diseases Tubereulosts 200 - Allersic, Endocrine, News, Note. Disesses Diabetes Mellitus 320 AIL Diseases of Nervous Sys. & Semse Oras 390 = A12 Disesses of Cireutacory System Chrone Mhevaatsc Heart Disease Arteriosclaroic K.0., Incl. 0 M11 vascular Lestons of os 460 ALL Respiratory Diseases ALL Paeveonta Eaphysens Ashes 520 - ALL Diseases of Digestive System ALL Gaseric and Duodensl Ulcer Cirrnosts of Liver 500 = ALL External Causes of Death a1 pcctdents Hotar Vehicle Accidents sutetde ALL Causes of Death o or u wm 2 ova a0 a as 12s ao aa To so ws 3 34.5 2. 2. Tze a a ae 2 24.5 a 3. & mow 6 a Tne wo 22 0 e486 1a "oes soa aa m a a as 3s 6 oa 2a 120 so ze 14 2a 0 ase Ime 6 2 aa 11 so ew " esa au 3 so 6 a os Ne a ware 183 11 ae soma soa aa us wes as 03134 fate J. Results ofWaClaevss.e-SCCpaheneccsteolrliciteMorPtlaanltity(5An6alsyosntisa) CoseofPeh M1 madtgnant Neoplases Cancer of Digestive Organs Feritonesm 150 - Cancer of Esophagus 151 = Cancer of Stomach 153 - Cancer of Large Intestine 154 - Cancer of Rectum 157 = Cancer of Pancreas Cancer of Respiratory System 161 = Cancer of Larynx 162 - AL) Concer of Lung (Peta. & Sec.) 172 = Cancer of Skin 185 = Cancer of Prostate 186 + Concer of Testis 169 = Cancer of Kidney 191 Cancer of Brat & Other cs M1 Lysphopotetic Cancer 201 Hodgkins Disease 108 - Cancer of Lysphattc Tiasue op omom ow oma one a an 3 5.0 1.0.3 Ls roe ow 0 aa Toes 0 as 329 11 a2 aa 110 10 0 se 2 1s 11a as 2 ozs aa aa 1s 1 0 0a TS 11s 0 so 2 10 20 2 aa 1 us was 1 10 10 0 se 21s 1a a as 4 oso 8 2 20 2 1s a es : 9 22 a wo 158 omer Digestive 1 195 111 Defined Stees 1 199 Nalig. Neopl. Without Specif. of Site 6 03135 : BEST COPY AVA ABLE . 1 Table 3, the 31 concer each are dscribueed by ste. one of he sess vere signtican. viet ant 5 govt abe Toe destin sn wen V5 Ser emptnge we for sc teas sx manc in the Chemical Division of che Cresotice Franc. vere, th eaters same of deaths (35) vn lens han expecens (66.1). his vas mainly the result of the lover than expected Dumber of deaths | Lom ssenses of the creutatery system. Th bighest OIE race, 5.2, curred for dent du vo ast. Fever, hin vaio, based on omy ingle 44th 1 oe 73 ear study periods vee nek sescietically signifies. A tote of 13 concer desc occurred amen the Chemical vision mate coterees. This as apreniasiely he mbes eapected C112). Aicheugh re 90 ast for 4 anes. oF ener, eines series mts 79 ween seectnete J-- . A seriburion of the 19 cherved death song fesele explores 4s 3 presented 1n Table 6. No major departures from expected vere noted in these siscnsion Th tower hen pected mosatacy from +13 couse 1 often fount 4m Jute of sccupactonal. coher. This veFleces "the healthy veskes cs. Coerely, tndividunls ho are $isbles or ehrankently 11 axe excluded from corata work stations, pariculariy hone requiring considerable shystent Acieker. Th, ploy cohorts compares to the genera] pepulacion generale 1 have ore favorable soraiey outcomes, parcieviarly for younger aployees. To compenace fox hin affect the duce could be reviewed vith an OE ratio of Jess 0 1, puchaps 3 1a preprint) considered equivalent to ne T itttermce Seruern chaerved and expected destha. Reviewing the dacs wich : c03136 : zante 4. ResMualltess.of CChoeumsiecaSlpeDciivfiiscioNnortGa6licMyontAhnsa)lysis Causeof Death ot or wu ow 140 = Malgnant Neoplasss Ln B22 6 as 200 - Allergic, Endocrine, Metab, Mute. Disesses Diabetes Nellitus 2 L119 2 ea 1s 1 0 es 320 = ALL Diseases of Nervous Sys. & Sense Organs 1 13 0 a0 350 = ALL Diseases of Circulatory System Artertosclerotic K.D. Incl. CHD 63 wows a 4 aa ou a 460 = ALL Respiratory Diseases ALL Pressonta hsthas 427 1s a as 21 1s a2 en 1a s2 a sma 520 = AI Disesses of Digestive Systea . ALL Gastric and Duodenal Ulcer 3 Cirrhosis of Liver 5% 14 324 uw a0 26 0 ws 13 oa ag 800 = AIL External Causes of Death ALL Acetdents Motor Vehicle Accidents Suteide 181 sa a 1212s 10 saa T0136 2a 2 36 6 a 20 AL Causes of Denth ss el 8 6 1a 03137  fale 5. ResMualltess.of CChaeussiec-aSlpeDciiiviicsioNnort(a3l6itKyoncAhnsa)lysis Cancer 140 - Malignant Neoplasms Bowe 12 6 ws Cancer of Digestive Organs & Feritonem 326 1 2 aa Cancer of Eaophagos 12 esa as Cancer of Large Intestine 1 12 0 es Cancer of Pancreas cancer of Respiratory System 16 18 0 02 "37 1a a as Cancer of Larynx 12 er a oma Cancer of Lung (Peta. & Sec.) 3 Cancer of skin Cancer of Prostate Cancer of Tests 3 as 1a 13 103 saa 20 0 wa 3s a ome wo a oma 199 - Malis. Neopl. Wichout Specification of Site = 3 05138 > . ) BEST COPY AVAIABLE Table 6. feSaprelceisf.ic CChoeumsoelsitoef PDleaanteh (36 nontha) 009 Diareheat disease 1 " 162 Melts. neopl. of lung 11 172 wadss. neopl. of skin 1 2 176 Nadia. mecpl. of bremst 2 25 18) Madde. neopl. of ovary 1 . 191 Malsa. oop. of brash 1 " 02 Wypertesasve nb. I Go acute 1. (2 Cnronte Tachente HD. 1 . ns @7 Symptomatic HD. 2 72 Tnllvenss vith other resp. mintfestations 1 1 3 ena 1 a B12 Car accident vich other car 19 Car ace. of unspecified nature 21 1s . Toca 1 03139 gL BESTCOPY Avan ABLE waliD.eat4hsnfooer sU.pSp.rewphietteemcaElmepserainsdonfeemaplueisnvieorne sutseehdt thoavdeeribveeenegxpeeecsteed for 404 he comten Vashrgton 10 In hich sh sapiayes ianesats and Perce resides, mnety and St. Crate fn Dake, Roeey Wacom, Tiere re co expects mor pblens with velo. First, spe unin sen te race from and chev cone comets specie so geviee denen ruses Src aot 1 such ALI by county fo periods aces contd be ertund From he Bac basic co the dnc, Sate 1540%s. he sebativety Suuend, sous fsopruicstioonmbiasbs evenrdeirgesdisifsfeeIrncenecpgehsrlfyoaostsracbhaliescracedosco.erOmaenssevrsuapie ata for de costes of For camer, ae sfucced sarest 1 deh sate relacion co the Unted Sumsen reruns are availabe by comty for tn pueses Bera1950-r65. Then co te ats were race for aomeirnevdsfosr tchee,shooverssehncoieenceosmouevsenmspee he rate vas bs ecsb Slarene on 2m scape of betwen che aces a east for Eh ome senh $ councte per and yen eh co ony 0.8, wor . for he unk Cancer where 3 counties than the he spe-adjuces race vas U.S. a a whele (che spprecianly oer gp 0 race for Renney comer of prenteeid 10. te ta he am U.S. case). The underestiouse of OI the tio 90 45 for lun cancer ver rene culculaced wing county 1am sunen. SKeIeEneI,OBTAeL-YClTualkaCein40 She 4m 9 using county Sof shou 1.5. ata co derive expecres virus which vol nat he sattnctontiy p-- About She results of umbofSeHRr, paretcutardy ftohriscahnaclaynsciesrsr,ev4e4sdlecdxcneosdsiegnnei.ticTanosn,ficnosnttinngeena,t een tor serait ie eerrenes, 03140 :. e BEST COPYAVAIIABLE As of the vesting of this report (February 36, 1980) information seatlble ac 2 ime th duce vas alpen dn 28 follows: 2 ated trom concer 3 ced trom fourtes susaiond 1a sn airplane crash 3 Ccaounnt cofoldeepaetehsuhnkanoamch(e2dofatcChahseadmuascheforcutrenrsed Gn wen) om the shove dtsribuion of deche, 1 obvious sha he C coa141