Document 0g2oyVeRG0QjdZQw6ogq0g67k

VAPOR PRESSURE TEST SUBSTANCE Identity:N-Ethylperfluorooctanesulfonamidmea;y alsobe referredtoas U 1464, ETFOSA, ETPOSA, F-6309, or FX-1 2. (1Octanesulfonamide,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-N-ethylC-A,S # 4151-50-2) Remarks: Materialisa whitesolid.Report statesthatsample purityis 99% based on informationsuppliedby Sponsoes representativeT.he lot number was not recorded. METHOD Method: OECD 104, Dynamic Method GLP (Y/N): Yes Year completed: 1998 Remarks: The followingquotefrom thetestreportdescribesthe onlytestdeviation: 'Whiletestingtestitem,the aircondenser was used inplaceofwater condenser because oflow meltingpointofthe testitem. To the bestof our (ASciCorporationc)urrentscientifkincowledge and understanding, thisdeviationshouldhave no effecton the outcome ofthistest."(Quote takenfrom the testreport). RESULTS Vapor Pressure: The vapor pressures at 10,20, 25, and 300C were 0.047,0.142,0.239,and 0.395 Pa, respectivelbyased on the increasing pressure regressionequation. Decomposition (yes/no/ambiguous): Not noted Remarks:. The estimatedvapor pressuresforthe increasingand decreasingpressureconditionsdiffebry 20 to24%. CONCLUSIONS The vapor pressureas determinedwiththe dynamic method was assumed tobe 0.142 Pa at200C based on the increasingpressure regressionequation. DATA QUALITY ReliabilitKyl:imiscrhankin=g2. Thisstudymeetsallthecriterfioar qualitytesting.However, the 99% puritymay notbe correct.The value was assigned by NMR which isincomplete.Possiblenon-linearplot(not enough data points). REFERENCES Study conducted atthe requestof3M Company by,ASci Corporation, Duluth,MN. OTHER Submifter: 3M Company, EnvironmentalLaboratory,P.O. Box 33331, St.Paul,Minnesota,55133 Last changed: 5/16/00 ASclRcport#045-VP.R3M ASclStudyID #5030-045-01 Page1 STUDY TTRLE Determinationof Vapor PressureCurve by Dynamic Method forU1464 (ET POSA) DATASTANDARD OECD Guideline104,"Vapor PressureCurve, Dynamic Method" AUTHORS Mike Signorelli Linda Christensen PhillipMarquis MDY COMPLETED November 6, 1998 TESTING FACILITY ASCI Corporation/AScl-Duluth EnvironmentalTestingDivision 4444 AirparkBoulevard Duluth,MN 55811-5712 Tel.No. (218)722-4040 STUDY IDENTIFICATION NUMBERS AScl Study ID# 5030-045-Ola 3M Company EnvironmentalTechnology and SafetyServices Sponsor Study ID# U1464 a This studyreportcontainstotalof 26 pages. The raw datapackage (34 pages)supportingthis studyiskepton fileatAScl-DEM. SponsorStudy ID# U1464 t, J ASCI Report#045-VP.R3M ASci Study ID #5030-045-01 Page 2 CERTMCANON OF GOOD LABORATORY PRACNCE COMPLIANCE To thebestof my knowledge,thisstudywas conductedin accordancewith OECD Good Laboratory Practicreegulation(s1). ASCI Study Director Name (signed) Name (typed):Iioi@'Christensen Date: 14 Sponsor Study M# ui464 ASci Report#045-VP.R3M AScl Study ID #5030-045-01 Page 3 STATEMENT OF OUALITY ASSURANCE The studydatawere reviewedby the'AScIQualityAssuranceUnit to assurethatstandardoperating proceduresand guidelinesused to conductthisstudywere followed,and thisreportisan accurate reflectioonf theraw data.The typesofauditsperformedforthisstudyarelisteidnthefollowing table. Type of Auditfor ASCI Study ED# 5030-045-01 Test Protocol in-Ufe Phase Raw Data and DraftReport FinalReport AuditDate 3/26/98 4/3198,4nlgs 5/27/98 11/4/99 Date ReportedtoStudy Directorand Management 3/27/98 4/6/98,4/8/98 5/27/98 1115/98 ASdI'sQualityAssuranceUnit Auditor Name (signed): do Name (typed):AlaMnozol Date: SponsorStudy ID# U1464 ASciReport#045-VP.R3M ASciStudyID #5030-045-ol Page4 TABLE OF CONTENTS COVER PAGE CERTIFICATION OF GOOD LABORATORY PRACTICE COMPLIANCE .............2. STATEMENT OF QUALITY ASSURANCE ..............................3.. TABLE OF CONTENTS 4 STUDY SYNOPSIS 6 1.0 INTRODUCTION 8 2.0 TEST hl=ODS 8 3.0 TREATMENT OF RFSULTS ..................................1.0. 4.0 RESULTS AND DISCUSSION .................................1.0. 5.0 CONCLUSIONS 6.0 DEVIATIONS FROM APPROVED TEST PROTOCOL 11 ....................11 7.0 REPORT SIGNATURE ......................................1.2 . 8.0 REFERENCES ...........................................12... TABLE ITABLE 2. TABLE 3. TA13LE 4- Toluene (ReferenceItem): BoilingPointsM and CorrespondingVapor Pressures(p) at IncreasingPressure ....................................13... Toluene (ReferenceItem): BoilingPointsM and CorrespondingVapor Pressures(p) atDecreasing Pressure ..................................1.4. Toluene (ReferenceItem): EstimatedVapor Pressures(p)atDifferentTemperatures M Determined from Equation1 .............................15. Toluene (ReferenceItem): EstimatedVapor Pressures(p)at DifferentTemperatures M Determined from Equation2 .............................1.6 . sponsor study ID# ul464 TableofContent(scont.) ASciReport#045-VP.R3M ASciStudyID #5030-045-01 Page5 TABLE5. Range of Vapor PressureValues forToluene by theDynamic Method from OECD and EEC-LaboratoryIntercomparisonTestingPrograms (4) .............1.7 TABLE 6. ET POSA (TestItem): BoilingPointsM and CorrespondingVapor Pressures(p)at RisingPressure ..................?.......................18. TABLE 7. ET POSA (restItem):BoilingPointsM and CpffespondingVapor Pressures(p)at DecreasingPressure ...................................19.... TABLE 8. ET POSA (TestItem): EstimatedVapor Pressures(p)atDifferenTtemperaturesM Determined from Equation3 ..............................2.0... TABLE 9. Fr POSA (TestItem): EstimatedVapor Pressures(p)atDifferenTtemperaturesM Determined from Equation4 ..............................2.1 .. TABLE 10. ET POSA (TestItem):ResponsibilitieSsi,gnaturesa,nd Initialosf Key Personnel Involvedi.n theStudy .................................2.2... FIGURE 1. A RepresentativPelotof Log P (Pa)and I/T (K) Toluene atIncreasinPgressure 23 FIGURE 2. A RepresentativPelotof Log P (Pa)aL@dI/T (K) Toluene atDecreasingPressure 24 .FIGURE 3. A RepresentatiPvleotof Log P (Pa)and I/T (K) ET POSA atIncreasing Pressure ........................................2.5.... FIGURE 4. A RepresentatiPvleotof Log P (Pa)and I/T (K) ET POSA atDecreasingPressure26 RAW DATA PACKAGE APPENDIX Approved Study Protocol#045-VP.P3M and Amendments APPENDIX B. TestItemInformation APPENDIX C. TestItemReceiptand Usage APPENDIX D. Raw DataSheets SponsorStudy ID# U1464 ASCIReport#045-VP.R3M ASelStudyID #5030-045-01 Page6 STUDY SYNOPSIS Title: Determinationof Vapor PressureCurve by Dynamic Method forU1464 (ET POSA) TestMethod: Dynamic method asdescribedin'AScIProtocol#045-VP.P3M Key Findings: 1) The estimatedvapor pressuresof the testitem,ET POSA, are0.142 and 0.176 Pa at20OC; and 0.239 Pa and 0.293 Pa at 250C. Study Slmnso Company: 3M EnvironmentalTechnology & SafetyServices 935 Bush Avenue Building2-3E-09 St.Paul,Minnesota 55133-3331 Study Representative: Dr. Rich Purdy Ecotoxicologist Phone: (612)778-5379 Fax: (612)778-6176 Test item Trade Name: ET POSA. Lot/BatchNumber: FC12 from John Eberlin3/12/98. SponsorStudy IdentificatiNounmber: U1464 MolecularFormula: C8Fl7SO2NCH2CH3 Chemical AbstractServiceRegistry#/Code#:TradeSecret PhysicalDescriptionW:hite waxy solid PercentPurity(% activeingredient9)9:% Based on informationsuppliedby Sponsor's Represeiitative. Sponsor Study ID# U1464 ASel Report #045-VP.R3M ASel Study ID #5030-045-01 Page 7 StabilitDyata: Stableatroom temperature. StorageConditions:Room temperaturein darkness. TesfinpF-agility Company: ASCI Corporation/AScI-Duluth EnvironmentalTestingDivision(ASCI) 4444 AirparkBlvd Duluth,Nfixinesot5a5811-5712 ASCI Study Director: Phone: Linda Christensen (218)722-4040 Fax: (218)722-2592 ReferenceItem Trade Name: Toluene. Lot/BatchNumber: 8608KTMH. CAS Registry#/Code#:108-88-3.PercentPurity:99.9%. Source: Mallinckrodt.Date ContainerOpened: 4/3/98. Study InitiatiDoante: 3/30/98. ExRcLnmental Dates ExRpn:men Determinationof Vapor Pressure StartingDate 4/3/98 TerminationDa 4/8/98 LocationRaw Data and FinalR=rt Certifiecdopieswillbe archivedat'testinfgacilitfyorfiveyearsfrom thedatethestudyis completed,afterwhich, theSponsorwillbe contactedtodeterminefurtherdispositioonf allrecords. Sponsor Study ID# U1464 ASelReport#045-VP.R3M ASclStudyID #5030-045-01 Page8 1.0 INTRODUCTION Chemical substancesintroducedintotheenvironment presentpotentiadlisposaland reentry hazards. The assessmentof environmentalfateand effectof thesesubstancesisrequiredby variousgovernmentalagencies.Accordingly,one of the testsistodeterminethevapor pressureof a substance.In thisexperiment,the testitem boilingpointisdeterminedata desiredpressureand thenvapor pressureand boilingpointare correlated. The vapor pressureof a substanceisan environmentallyrelevantpropertybecause(1)it indicatestheprobabilitoyf phase transitionv,olatilizati(olniquid/gaso)r sublimation (solid/gas)o,f a chemical,(2)ithelpssubstantiatperedictionrsegardingtheenvironmental behaviorof chemicals,(3)chemicalvaporpressureand watersolubilitayllowforthe. calculatioonf chemicalvolatiliftryom an aqueoussolutiona,nd (4)itisusefulindeciding whether photochemicallyinduceddegradationcan be determinedin thehomogenous gas phase or inan absorbedphase (OECD 1993). 2.0 TEST METHODS 2.1 Glassw All glasswareemployed were cleanedbeforeuse by performingthefollowing: 1) -Washed in hot detergentwater and rinsedthreetimeswith warm tapwater. 2). Immersed in 10% HN03 acidbathand then rinsedwith deionizedwater. 3) Rinsed threetimeseach with acetonefollowedby hexane. All glasswareused were labeledwith therelevantinformationrequiredforproper identification. 2.2 Test item. The testitem,ET POSA, materialsafetydatasheets,and cerdficatoef analysis were receivedatASCI on March 27, 1998. The testitem was inone glassbottleand was storedatroom temperaturein darknessasreceived.All relevantinformatioanboutthetest itemisdescribedearlieirnthisreport.In thistest,13.39g of testitemwas used. 2.3 ReferenceItem. Reagentgrade toluenewas used as a referencechemical.All relevant informationaboutthereferenceitemisdescribedearlieirn thisreport.In thistest,35 ml of referencechemicalwas used. 2.4 Test ARparatus. The testsystem consistedof: 5-L Ballastbulb to vary pressurein double-neckdistillatifolnask. Sponsor Study ID# U1464 ASel Report #045-VP.R3M AScl Study ID #5030-045-01 Page 9 2) Closed-tubemercury manometer to measure pressure. 3) 100-ml double-neckdistillatifolnask. 4) Centigradethermometer, 0.2*C, with one holerubberstoppertofit in thedistillatifolnask. 5) Reflux condenser. 6) Heating element. 7) Vacuum pump. 8) Aspirator. 9) Boilingstones. 10) Nitrogencylinder. 2.5 DeterminationofVaMr Pressure.The proceduretodeterminethevapor pressuresof test and referenceitemswas as follows: 1) Placedthe item indouble-neckdistillatifolnaskata volume aboutone- thirdtheflaskvolume, and added threetofourboilingstones. 2) Flanged testsystem togetherand purged itwith nitrogen.The pressure in thesystem was adjustedusingvacuum. 3) Heated the item graduallyuntiltemperatureequilibriuwmas reached, thatis,when a constantboilingtemperaturewas found.' 4) At thispoint,recorded totalpressure(inmm Hg) and boilingpointT (in*C). 5) For atleastfivedifferenptressures,increasedpressureand recorded new totalpressuresand boilingpointswhen equilibriwaere reached. 6) To obtainthesecond setof data,recordedtotalpressureand boilingpointas the pressurewas lowered. Sponsor Study ID# U1464 ASclReport#045-VP.R3M ASclStudyID #5030-045-01 Page10 3.0 1 -A'TMENT OF RESULTS For each data setwith testand referenceitems,totalpressurewas convertedto Pa unitby muttiplyintgheobservedmillimetemrercurypressurewith 133.3. Similarlyt,heboiling pointM was convertedto *K by adding273.15 totheobserved*C boilingpoint.The log of totalpressure(Pa)vs.(1/T)from theindividuadlatasetswere regressedtodevelopthe vapor pressurecurvesforeach item. Vapor pressuresfor thetestitem and the reference item were determinedat10*C, 20*C, 25*C, and 30*C usingappropriatleinearregression equations. 4.0 RESULTS AND DISCUSSION ReferenceItem: Toluene The observeddataobtainedforincreasinagnd decreasingthepressureare shown in Tables I and 2, respectivelfyortoluene.The calculaterdegressioncurvesfrom the plottedcurves, Figures1 and 2, are: Increasingpressure: logp = 10.27-1994(1/T) r = -0.999n, = 5 (1) Decreasing pressure: logp = 10.35-202(3I/T) r = -0.998,n = 5 (2) The two datasetsare similarand have correlatiocnoefficientgsreaterthan0.995. The estimatedvaporpressuresat10,20, 25, and 30*C are listedinTables3 and 4 forthe two toluenedatasets.Table5 listtsherangeof vapor pressurevaluesdeterminedby the dynamic method from interlaboratocroymparisons(4). The toluenevapor pressuredseterminedfrom equationI arewithinthe rangeslistedforthe interlaboratocroymparisons.The valuesdeterminedfrom equation2 are slightllyower at10 and 20*C. The vaporpressurefortolueneat20*C (2.8X 103 Pa)islower thanthecriterion establisheidn.theprotocol(2.9-3.1X 103Pa). The vaporpressurefortolueneat 10*C (1.6X 10-3 Pa) islowerthanthecriteriosntatedinreference4 (1.7-1.8X 10-3Pa). A problem occurredwiththesystemas thepressurewas decreased.To getthe tolueneto boil as thepressurewas decreased,more boilingchipswere added to theitem. Itisnot clear whether thiswould have affectedthe temperatureand pressuremeasurements. Sponsor Study ID# U1464 ASclReport#045-VP.R3M A&I StudyID #5030-045-01 Page11 The experimentaldesignpresentedh.erefordeterminingvapor pressurecurvesappearsto providedatacomparabletothatreportedinreference4. The regressiocnurvesare linearfor both increasingand decreasing'pressures. TestItem: ET POSA The observeddataobtainedforincreasingand decreasingthepressureare shown inTables 6 and 7, respectivelyT.he calculaterdegressiocnurvesfrom the plottedcurvesof log p vs (1/T),Figures-3and 4 are: Increasinpgressure: logp = 12.64-3954(I/T) r = -0.999,n = 5 (3) Decreasing pressure: logp = 12.45-3871(1/T) r = -0.997,n = 5 (4) The estimatedvapor pressuresat 10,20, 25, and 30*C arelistedinTables8 and 9 forthe testitem. The estimatedvapor pressuresfortheincreasingand decreasingpressure conditiondsifferby 20 to24 percent. 5.0 CONCLUSIONS The placementof thethermometerin theapparatusproved to be'pivotalin establishing accurate,steadytemperaturemeasurements. The placementof thethermometer forthetest item was differentthanthatof thereferenceitem. The thermometerwas placed approximatelyone inchabove thebubblingtestitem*inthecollectiofnlask.The thermometerforthereferenceitem was placedin the neck of thecollectiofnlask. Based on theincreasinpgressureregressionequation,thevapor pressuresat 10"C, 20"C, 25 *C, and 30*C were 0.047 Pa, 0.142 Pa, 0.239 Pa, and 0.395 Pa, respectively. 6.0 DEVIATIONS FROM APPROVED TEST PROTOCO The deviatiownhich occurredwhileconductingthisstudyis: 1) While testintgestitem,theaircondenserwas used inplaceof watercondenser becauseof low meltingpointof thetestitem. Sponsor Study ID# U1464 ASciReport#045-VP.R3M A&I StudyID #5030-045-01 Page 12 To the best of our currentscientifikcnowledge and understanding-,thidseviationshould have no effecton theoutcome of thistest. 7.0 RIEPORT SIGNATURE ASCI Study Di;reeccttoo Name (signed)- Date: L Name (typed):LindaChristensen Responsibilitiesi,gnaturesi,nitialsa,nd names of key personnelinvolvedinthisstudy are in Table 10. 8.0 REFERENCES 1) OrganizationforEconomic Cooperationand Development (OECD), 1993. OECD GuidelinesforTestingof Chemicals. OECD PublicatioInnformationCenter, Washington, DC. 2) Shoemaker, D.P. and C.W. Garland. 1962. Eiperimentsin Physicalchemistry. McGraw-Hill.Book Co., pp. 162-163. 3) OrganizationforEconomic Cooperationand Development (OECD), 1997., Environment DirectorateC,hemicals Group and Management Committee. OECD Serieson Principlesof Good LaboratoryPracticeand Compliance Monitoring. Number 1. OECD Principleson Good LaboratoryPractice. SponsorStudyID# U1464 TABLE 1. mmHg 47 64 77 100 124 ASci Report #045-VP.R3M ASci Study ID #5030-045-01 Page 13 Toluene'(Reference'ltem):BoilingPoints(1) and CorrespondingVapor Pressures(p)at IncreasingPressure Memred Pressure p (Pa) 6265 8531 1026413330 16529 Log p (Pa) 3.797 3.931 4.011 4.125 4.218 T (OC) 35.0 41.2 45.5 51.2 56.5 Observed Tempemture T (-K) 308.15 314.35 318.65 324.35 329.65 I/T(-K) 0.003245 0.003181 0.003138 0.003083 0.003034 Sponsor Study ID# U1464 TABLE 2. mmHg ISO 128 110 77 52 AScl Report #045-VP.R3M AScl Study ID #5030-045-01 Page 14 Toluene (ReferenceItem): BoilingPoints (7).and Corresponding Vapor Pressures(p)at Decreasing Pressure Memred@ Press=-ure p (pa) Log P (Pa) 19995 17062 4.301 4.232 14663 4.166 10264 4.011 6932 3.841 Observed Temperature T (OC) T (OK) 61.2 334.35 57.7 330.95 53.6 326.75 45.0 -]F 318.15 38.0 -T 311.15 I/T(-K) 0.002991 0..003023 0.00306 0.0.03143 0.003214 Sponsor Study ID# U1464 AScl Report #045-VP.R3M ASR-IStudy ID #5030-045-01 Page 15 TABLE 3. Toluene (ReferenceItem): Estimated Vapor Pressures(p)at Different Temperatures M Determined from Equation I T (OC) 10 20 25 30 Vapor Pressur-(cPa) 1.7 X 103 2.9 X 103 3.8 X 103 4.9 X 103 VaporPremre (mmHg) 12.7 22.0 28.6 36.9 Sponsor Study ID# U1464 ASci Report #045-VP.R3M ASci Study ID #5030-045-01 Page 16 TABLE 4. Toluene(ReferenceItem): EsirunatiVdapor Pressures(p)at Different Teinperatum (1)Determinedfrom Equation2 T (*C) 10 20 25 30 Vapor Pressure(Pa) . 1 .6 X 103 2.8 X 103 3.7 X 103 4.9 X 103 Vapor Premm (mmHg) 12.0 21.1 27.5 35.6 Sponsor Study ID# U1464 TABLE 5. ASci R"rt #045-VP.R3M ASel Study ID #5030-045-01 Page 17 Range of Vapor PressureValues for Toluene by the Dynamic Method from OECD and EEC-Laboratory IntercomparisonTestingPrograms (4) Tempp,rattm(*C) 10 20 30 Range of Vapor Pressure(Pa) (1.7-1.8)X 103 (2.9-3.1X) 103 (4.9-5.0X)10 SponsorStudyID# U1464 TABLE 6. mrnhg 42 58 68 83 94 AScl Report #045-VP.R3M AScl Study ID #5030-045-01 Page 18 ET POSA (TestItem) Boilingpoints(1) and CorrespondingVapor Pressures (p)at RisingPressure Observed Premre P (Pa) 5599 7331 9064 11064 12530 Log p (Pa) 3.748 3.998 3.957 4.044 4.098 T (-C) 171.6 178.9 181.8 186.4 190.2 Observed Tempemture T T (-K) 444.75 451.95 454.95459.55 463.35 I/T(-K) 0.002248 0.002213 0.002198 0.002176 0.002158 Sponsor Study [D# U1464 TABLE 7. mmHg 106 95 86 75 47 ASCI Report #045-VP.R3M AScl Study ID #503G-045-01 Page 19 ET POSA (TestItem): Boilingpoints(1)and CorrespondingVapor Pressures (p)at DecreasingPressure Observed Pmmre p (Pa) 14130 12664 11464 99W---T6265 Log p (Pa) 4.150 4.103 4.059 4.000 3.797 T (OC) 193.0 191.0 189.0 183.8 174.4 Observed Tempemture T (*K) 466.15 464.15 461.15 456.95 447.55 I/T (OK) 0.002145 0.002154 0.002168 0.002188 0.002234 Sponsor Study ID# U1464 ASci Report #045-VP.R3M ASci Study ID #5030-045-01 Page 20 TABLE 8., ET POSA (TestItem): EstimatedVapor Pressures(p)at Different Temperatures M Determined from Equation 3 T (OC) 10 20 25 30 Vapor Pressure(Pa) 0.047 0.142 0.239 0.395 Vapor Pressure(mmHg) 0.36 X 10-3 1.06 X 10-3 1.79 X 10-3 2.97 X 10-3 Equation3 - Log Pa 12.64-3954(lfl) ExiMle Calculation Log Pa = 12.64-3954(IM 10*C = 283.15*K Log Pa = 12.64-3954(1/283.15) Log Pa = 12.64-13.9643 Log Pa = 1.3243 Pa = Inv Log (-1.3243) Pa = 0.047 For mm Hg 0.047 133.33 0.36 X 10-3 Sponsor Study ID# U1464 AScl Report #045-VP.R3M ASci Study ID #5030-045-01 Page 21 TABLE 9. ET'POSA (TestItem): EstimatedVapor Pressures(p)at Different Temperatures M Determined from Equation 4 T'(OC) 10 20 25 30' VVor Prmum (Pa) 0.060 0.176 0.293 0.479 Vapor Pressure(mmHg) 0.45 X 10-3 1.32 X 10-3 2.20 X 10-3 3.60 X 10-3 Equation4 L4Dg Pa 12.45-3871(IM Sponsor Study ID# U1464 AScl Rcport #045-VP.R3M ASci Study ID #5030-045-01 Page 22 TABLE 10. ET POSA (TestItem): ResponsibilitieSsi,gnatures,and Initialosf Key Personnel Involved in the Study iersonnel Title/Responsibility LindaChriswasen Study Director U4 Mike SiporcHi IAboratoryassistance Alan Mozol QualityAs@umce Auditor Joe Amato ProjectManager PhilliMparquis ReportPreparation Naney Jordan Archivist Signature -'7e Initials Sponsor Study [D# U1464 Figure1. A RepresentativePlotofLog p (Pa)and 1/T(K)forToluenIncreasingPressure 4.254.204.154.104.05CL4.00 0 3.953.903,85 3.80 3.75 0.00300 0.00305 0.00310 0.00315 I/T(K) 0.00320 0.00325 Sponsor Study ID# U 1464 Figure 2. A RepresentativePlotofLog p (Pa)and 1/T(K)forToluene Decreasing Pressure 4.40- 4.30- 4.20CL d4.10 0 4.00- 3.'90- 3.80 0.00295 0.00300 0.00305 0.00310 1/T (K) 0.00315 0.00320 Sponsor Study ID# U1464 Figure3.A RepresentatPilvoetofLogp (Pa)and 1/T(K)forET POSA IncreasiPnrgessure 4.15 4.10 - 4.05 - 4.00 - a-m 3.95 - CL 0 3.90 - 3.85 - 3.80 - 3.75 - 3.70 1 0.002140 1 0.002160 0.002180 0.002200 IIT,K 0.002220 0.002240 Sponsor Study ID# U 1464 Figure4. A RepresentativePlotofLog p (Pa)and 1/T(K)forET POS7) - Decreasing Pressure 4.20 4.15 4.10 4.05 0%...0 4.00 - CL 003.953.90 3.85 3.80 3.75 0.00214 0.00216 0.00218 0.0022 I/T(K) 0.00222 Sponsor Study ID# U 1464