Document 0Lz69b7wg4v3r9GvpkVpykZqO

- -a* tJ.F. AV'H lo^'4 THE NEW YORK ACADEMY OF SCIENCES April 10, 1974 Dr. James Freeman Allied Chemical Corporation P.0. Box 1057R - Solvay 1 Morristown, N.J. 07960 Dear Dr. Freeman: You are cordially invited to participate in a Working Group on Vinyl Chloride - Polyvinyl Chloride on May 10 - 11, 1974 at the Delmonico Hotel, 59th Street and Park Avenue, New York City. As you know, registration starts at 8:00 a.m. on the first day. We are attaching your pocket card; would you please be sure to bring this with you. Besides serving as an identification card, it will expedite registration. The program and other materials will be available for you at the conference. Attendance is limited to a relatively small group representing diverse fields of interest and space is in great demand. Therefore, should your plans change, kindly let us know at your earliest opportunity. We look forward with great pleasure to your participation. Irving J. Selikoff, M.D. E. Cuyler Hammond, Sc.D. Cochairmen 2 East 63rd Street, New York 10021, Phone (212) 83&0230 Cable NYACSCI KSl 000015583 THE NEW YORK ACADEMY OF SCIENCES (Founded in 1817) BOARD OF GOVERNORS, 1974 E. CUYLER HAMMOND, President PHILIP FEIGELSON, President-Elect Honorary Chairman of the Board of Governors BORIS PREGEL I. B. LASKOWITZ MARGARET MEAD Honorary Life Governors Vice-Presidents HERMAN COHEN JOEL L. LEBOWITZ Recording Secretary PAUL MILVY Treasurer GORDON Y BILLARD DETLEV W, BRONK Elected Governors-at-Large 1972-1974 HAROLD D. LASSWELL CHARLOTTE FRIEND MARIE M. DALY 1973-1975 SIDNEY ROTH 1974-1976 RENE DUBOS KENNETH WADE THOMPSON SERGE A. KORFF BERTN. LA DU, JR. Past Presidents (Governors) LLOYD MOTZ Counselors to the Board of Governors Financial Counselors FREDERICK A. STAHL MATTHEW B. ROSENHAUS Budget Counselor GEORGE B. DAETZ BORIS PREGEL H. CHRISTINE REILLY SEYMOUR MELMAN ETHEL TOBACH Corresponding Secretary GEORGE L FUJIMOTO ROSS F. NIGRELLI PHILIP SIEKEVITZ HERBERT J. KAYDEN IRVING J. SEL1KOFF MINORU TSUTSUI N. HENRY MOSS Legal Counselor EDWARD D. BURNS CHAIRMEN AND VICE-CHAIRMEN OF SECTIONS SECTION OF ANTHROPOLOGY STANLEY FREED, Chairman MAY EBIHARA, Vice-Chairman SECTION OF ATMOSPHERIC SCIENCES RAYMOND J. DELAND, Chairman WALTER ZELTMANN, Vice-Chairman SECTION OF BIOCHEMISTRY BERNARD DUBNICK, Chairman MARY J. MYCEK, Vice-Chairman SECTION OF BIOLOGICAL AND MEDICAL SCIENCES CRAIG D. BURRELL, Chairman ERICH HIR5CHBERG, Vice-Chairman SECTION OF BIOPHYSICS SIGMUND E. LASKER, Chairman ADORJAN ASZALOS, Vice-Chairman JOHN HAPPEL, Chairman SECTION OF CATALYSIS WILLIAM R. MOSER, Vice-Chairman SECTION OF CHEMICAL SCIENCES MARVIN L. POUTSMA, Chairman RICHARD W. FRANCK, Vice-Chairman SECTION OF COMPUTER AND INFORMATION SCIENCES SYLVIA WASSERTHEIL-SMOLLER, Chairman EMILE C. CHI, Vice-Chairman SECTION OF ENGINEERING THOMAS C. KAVANAGH, Chairman PAUL N. CHEREMISINOFF, Vice-Chairman SECTION OF ENVIRONMENTAL SCIENCES MORRIS KLEINFELD, Chairman GEORGE KUPCHIK, Vice-Chairman SECTION OF GEOLOGICAL SCIENCES JOHN SANDERS, Chairman WALTER S. NEWMAN, Vice-Chairman SECTION OF INSTRUMENTATION WILLIAM GRUEN, Chairman ROBERT W. HAMILTON, Vice-Chairman JOHN BEATTY, Chairman SECTION OF LINGUISTICS LAWRENCE J. RAPHAEL, Vice-Chairman SECTION OF MATHEMATICS ALLAN GEWIRTZ, Chairman PAUL MEYER, Vice-Chairman ALLEN LASKIN, Chairman SECTION OF MICROBIOLOGY SHALOM HIRSCHMAN, Vice-Chairman SECTION OF ORGANOMETALLIC CHEMISTRY EDWIN H. ABBOTT, Chairman NEIL McKELVIE, Vice-Chairman SECTION OF PHYSICAL SCIENCES HEINZ PAGELS, Chairman FRED COOPER, Vice-Chairman SECTION OF POLYMER SCIENCE DARRELL MORROW, Chairman JAMES E, McGRATH, Vice-Chairman SECTION OF PSYCHOLOGY KURT SALZINGER, Chairman FLORENCE DENMARK, Vice-Chairman SECTION OF SCIENCE AND PUBLIC POLICY PHILIP SIEKEVITZ, Chairman HAROLD FRUCHTBAUM, Vice-Chairman The Sections hold meetings regularly during the academic year, October to May, inclusive, at The New York Academy of Sciences, 2 East Sixty-third Street, New York, N.Y, 10021. Conferences are also held at irregular intervals and announced by special programs. ASI 000015584 ALLIED CHEMICAL CORPORATION MEMORANDUM May 29, 1974 MEMO TO FILE SUBJECT: New York Academy of Sciences Workshop on the Toxicology of Vinyl Chloride Instead of the expected attendance of less than 250 people, there were about 400 at the meeting. The room was packed and much excitement was evident. The tone of the conference for the first day seemed to be one of presenting the known facts and data as received that date without the introduction of hysteria or "political" statements. Th*anghr^V<^e ^ speakers made reference to the relationship between arsenic (form unspecified) and angiosarcomas of the liver. On Saturday, the list of speakers included some union people and some from the NIH & NCI. The tone of these people was very critical of industry/ apf labor seemed to be using the meeting as a tool to further their cause of sitting and the management table as concerns health issues. When V. K. Rowe of Dow announced that MCA ves sponsoring an inhalation study at low levels of VCM (% 50 ppm) exposure, several of these people voiced opposition - calling it a "secret" study. Sometime later, M. A. Schneiderman of the NCI criticized the proposed MCA study as being secret and ill-conceived. Many of the NIOSH, NGI and labor group responded by clapping. ASI 00001558 The meeting was well covered by the press;, and many state ments of the better known speakers were quoted, some erroneously, such as the one that reported that angiosarcomas had been caused Page 3 mechanisms were similar and that the "sulphydryl links" were affected. cx 6. In a question and answer session se doctor from the Mass. Dept, of IH said that PVC , with no possible exposure to VCM, had caused some health problems in some plant in Mass. 7. Dr. C. Levinsen, International Federation of Chemical and General Workers Unions, Geneve^ Switzerland: Outlined international labors concern over VC worldwide - Stated. a) Economics didn't impress them. b) Their goal: to erase the interface to between and labor; "In a few years we'll be on your board of directors." 8. G. Schweitzer of the EPA: Indicated that 4-8$ of(2 x 10^ lb/yr) were lost to the atmosphere during manufacturing operations. They want epidemiological studies in adjacent communities It was Indicated that the National Center for Cancer Studies (Arkansas) is prepared to assist. Indicated the T^ for VCM in air may be on the order of hours. "Industry has the responsibility to know the 'fate' of their products." 9. G. Berkel, AFL-CIO: Plead for: Laws requiring cancer screening for all new industrial products - medical exams after exposure to VCM has ceased and that the government set up surveillance programs to do so. ASI 000015586 Page 2 In VCM and film,plants, when in truth, the only cases have beep^n the polymer plants. Conversations in the hallways and lounges covered the whole spectrum of thought from those who ridiculed the whole VCM problem as a scare to those that advocate zero tolerance. Some of the comments made by the various speakers are listed below: 1. Dr. Creech of BPG: Carefully outlined the history of the BPG problem and their reaction as he saw it. Additionally, he pointed out the difficulty of preassessing the angiosarcoma con dition. Some of the patients had no symptoms whatsoever, others showed some outward sides (at late stages), but liver function tests were still okay. 2. Dr. Mill^of Mt. Sinai: He had done some study of the lung functions of VCM workers which indicated that after 20 years, most non-smokers have as many lung problems as smokers; Indicating occupational disease. 3. Dr. Popper NIH & Mt. Sinai: Talked on the alteration in spleen and liver (at autopsy) and indicated that arsenic caused a very similar appearing angiosarcoma. 4., Dr. Gedick of the University of Bonn: Again mentioned the arsenic link. 5. Dr. Gehring Dow: AS I 000015587 Talked on the biochemical studies. He that the Ti(BIO) is about 40-75 minutes and that the ability of rats to metabolize VCM can easily reach saturation. He mentioned the arsenic cancer link and thought that perhaps the ' Page 4 10. A. Mazzocchi - I.U.B. Political and financial pressures bring solutions to health problems not technical and scientific efforts. He is quite a "hip shooter." 11. E. C. Hammond ACS: Defined a high level of exposure as any level that causes occupational disease. However, he disagreed strongly with the "zero risks" exposure theory. 12. Sir Richard Doll, Oxford University: a) Doctors cause more cancers than industry, i.e. by treatments - Choroblast. b) Cancer is a proeess rather than an effect. c) Scored industry for not having ongoing medical programs to detect and predict occupational disease. AS I 000015588 ibcn THE NEW YORK ACADEMY OF SCIENCES 2 East Sixty-third Street New Yotk, N.Y. 10021 MAY 10, 11r 1974 WORKING GROUP TOXICITY OP VINYL CHLORIDE POLYVINYL CHLORIDE & Cajfer E , Se.D., Herbert J, Kaydm, MJ>,, Cldmaa, Conference Committee Co-Speeien: Americ-- Cancer Society Notional Instttate of Envlromaeatol HeaMh Sdcswes National hMtitnte for Occupational Safety ood Health Society for Occupational and Environmental Health THE DELMONICO HOTEL Part Avenue a 59ft Street New York, N.Y. 10022 FRIDAY, MAY 10.1974 CONFERENCE CHAIRMEN: Irving J. Selikoff, M.D. Mount Shui School of Medicine of the City University of New York and E. Cuyki Hammond, Se.D, American Cmccr Society New York City. N.Y. 8:00 A.M. REGISTRATION 8:45 A M. GREETINGS FROM THE ACADEMY E. C. Hammond, Sc.D., President INTRODUCTORY REMARKS I. J. SeUkoff, M.D., Mount Saud School of Medicine of the City University of New York 9:00 A, M. MORNING SESSION SESSION CHAIRMAN M. M. Key, M.D. Rockville, Md NON-MALIGNANT DISEASE CHAIRMEN E. Mastromstteo, M.D. International Labour Office Geneva, Switzerland M. N. Johnson, MD. B. F. Goodrich Co. Akron, Ohio I a CLINICAL MANIFESTATIONS AND COURSE OF VINYL CHLORIDE DISEASE G. Veltman, M.D, C. E. Lange, M,D,,S. JDbe, M.D., G. Stein, M.D. and U. Badmer, M.D., University of Bonn, Bonn, Germany b. FURTHER RESULTS IN POLYVINYL CHLORIDE PRODUCTION WORKERS C. E. Lange, M.D., S. Juhe, M.D., G. Stein, M.D. andG, Veltman, M.D., University of Bonn, Bonn, Germany 2. DISEASE AMONG VINYL CHLORIDE POLYVINYL CHLORIDE WORKERS IN ROMANIA--OBSERVATIONS 1963-1973 I. Suciu, M.D., L. Prodran, M.D., E. Hea, M.D., A. Paduram, M.D., C. Vakszkxi, M.D. and L. Pascu, M.D., Occupational Diseases Gink, University of Cluj, Romania FRIDAY, MAY 10, 1974 3. LIVER DAMAGE AMONG POLYVINYL CHLORIDE PRODUCTION WORKERS J. L. Creech, M.D. and L Makk, M.D., University of Louisville, Louisville, Ky. 4. ACROOSTEOLYSIS IN VINYL CHLORTDE PLANTS IN JAPAN H Sakabe, M.D., National Institute of industrial Health, Kawasaki, Japan 5. PREVALENCE OF DISEASE AMONG VINYL CHLORIDE AND POLYVINYL CHLORIDE WORKERS R. Ulis, M.D., S. Daum, M.D., H. A. Anderson, M.D., S. A. Fischbein, M.D. and I. J Selikoff, M.D., Mourn Sinai School of Medicine of the City University of New York Discussion opened by: P. Berk, M.D,, National Institute of Arthritis, Metabolic and Digestive Diseases, Bethesda, Mainland and A. Miller, M. D., Mourn Sinai School of Medicine of the City University of New York 6. UNUSUAL SPLENOMEOAUC UVER DISEASE AS EVIDENCED BY PERITONEOSCOPY AND GUIDED UVER BIOPSY AMONG POLYVINYL CHLORIDE PRODUCTION WORKERS H J. Marsteller, M.D., W, K. Lelbach, M.D ,K Muller, M.D. andP. Gedigk, M.D., University of Bonn, Bonn, Germany. 7. ALTERATIONS OF UVER AND SPLEEN AMONG WORKERS EXPOSED TO VINYL CHLORIDE H. Popper, M D., Fogarty Center, National Institutes of Health, Bethesda, Maryland and Mount Sinai School of Medicine of the City University of New York, and L. B. Thomas, M.D , Natinni1_fhh~t InrtjQitr Bethesda, Md. ERVATIONS E. J. Fairchild, IT, Ph.D. National institute for Occupational Safety and Health RockviflerMdr- 8. BIOCHEMICAL APPROACHES TO EVSCUATl ON OF BIOLOGICAL EFFECTS OF VINYL CHLORIDE P. Gehring, Ph.D., Dow Chemical Company, Midland, Michigan . AS I 0 0 0 0 1 5 5 8 9 FRIDAY, MAY 10.1974 Discussion opened by: G. Otter, Ptt.D., Mown Sinai School of Medicine of the Gty University of New York and R l. Jaeger, Ph.D., Harvard School of Public Health, Boston, Mass. LUNCHEON 2 00 P M. AFTERNOON SESSION SESSION CHAIRMAN R. S. F Schilling, M.D. London School of Hygiene and Tropical Medicine London, England NEOPLASTI EFFECTS CHAIRMAN I, W. Uoyd, Sc.D. National Institute for Occupational Safety and Health Rockville, Md. 9. CHARACTERISTICS OF CASES OF ANGIOSARCOMA OF THE LIVER IN U.S. VINYL CHLORIDE - POLYVINYL CHLORIDE WORKERS C. W. Heath, Jr, M.D and H. Falk, MD, Bureau of Epidemiology, Center for Disease , Control, Atlanta, Georgia 10. MORTALITY STUDY OF POLYVINYL CHLORIDE WORKERS ], R. Tabershaw, M.D., and W, Gaffey, Ph D,, Triwrshaw.Cooper Associates. Inc.. Berkeley, California 11. INDUSTRY-WIDE INVESTIGATION OF DISEASE MANIFESTATIONS AMONG WORKERS EMPLOYED IN VINYL CHLORIDE -- POLYVINYL CHLORIDE PRODUCTION i. K Wagoner, S.D. Hyg., 1. Mallov, M.D and W. Stringer, M.D., National Institute for Occupational Safety and Health. Cincinnati, Ohio. 12. MORTALITY EXPERIENCE OF A COHORT OF VINYL CHLORIDE - POLYVINYL CHLORIDE WORKERS, 1946-1973 W, J. Nicholson, Ph.D., E.C. Hammond, Sc.D. and 1. J. Sdikoff, M.D., Mount Sinai School of Medicine of the City University of New York and the American Cancer Society, New York City, New Yotk, Discussion opened by: T. F. Mancuso, M.D., University of Pittsburgh School of Public Health, Murid L, Newhouse, M. D., London School of Hygiene and Tropica) Medicine, London, England and FRIDAY. MAY. 10,1974 B. Holmberg, PhD., National Board of Occupational Safely and Health, Siockhohn, Sweden. 13. PATHOLOGY OF ANGIOSARCOMA OF THE LIVER AMONG VINYL CHLORIDE POLYVINYL CHLORIDE WORKERS L, B. Thomas, M.D. and H. Popper, M.D . National Institutes of Health, Bethesda, Md. Discussion opened by: H. L. Stewart, M D., National Cancer Institute, Bethesda, Md. and 0. Auerbach, M.D., Veterans Administration Hospital, East Orange, N.J EXPERIMENTAL OBSERVATIONS CHAIRMAN (J. Saffkati, M.D. National Cancer Institute Bethesda, Md. 14. HEMATOGENOUS DISSEMINATION OF INGESTED PVC MICROPARTICLES G. Vdkheimer, M.D., Berlin, Germany 13. CARCINOGENICITY B10-AS5AYS OF VINYL CHLORIDE: CURRENT RESULTS C. Matoai, M.D. and G. Lefiemme, M.D., Institute of Oncology and Tumor Center, Bologna, Italy 16. EXPERIMENTAL STUDIES WITH VINYL CHLORIDE M L. Keptmger. Ph D., J.W Goode, Ph.D., D.E. Gordon, D.V.M., Ph D., and 1 C. CtUndrm, M.D., Ph.D., Industrial Bio-tesi Laboratories, Inc., Northbrook, Dl Discussion opened by: EuLa Bingham, Ph.D. University of Cincinnati, Cincinnati, Ohio and B.L. Van Duuren, Ph.D. New York University New York City, N,Y. 730 P.M. SUBSCRIPTION DINNER DELMOMCO HOTEL SATURDAY, MAY It, 1974 9:00 A.M. MORNING SESSION SESSION CHAIRMAN E. Dixon, M,D. Celanese Corp. New York City. N.Y. SATURDAY, MAY 11, 1974 C NTH L FEXP SURE CHAIRMAN C. Levinson International Federation of Chemical and General Wcikers" Unions Geneva, Switzerland \7. EXPERIENCE IN INDUSTRIAL EXPOSURE CONTROL V. K. Rowe, Ph.D., Dow Chemical Company, Midland, Michigan 18. THE ENVIRONMENTAL THREAT FROM VINYL CHLORIDE BEYOND THE WORK PLACE G. Schweitzer, Ph.D., Environmental Protection Agency, Washington, D.C. Discussion opened by: M. Com, Ph D., University of Pittsburgh School of Public Health, Pittsburgh, Pa. and V. A. Newill, M.D.. Environmental Protec tion Agency, Washington, D.C, PROBLEMS AND PERSPECTIVES CHAIRMAN N. J. Roberts, M.D. Exxon Corporation New York City, N.Y. 19. CLINICAL MANAGEMENT OF WORKERS EX POSED TO VINYL CHLORIDE AND POLYVINYL CHLORIDE C. A. Johnson, M.D., Goodyear Tire and Rubber Company, Akron, Qtrio 20. SURVEILLANCE OF WORKERS WITH HISTORY OF EXPOSURE TO VINYL CHLORIDE L. Belkxky, A, Mazzocchi and G, Perktl, Vinyl Chloride Health Committee, Industrial Union De partment, AFL-CIO, Washington, D.C 21. EPIDEMIOLOGICAL APPROACHES TO THE EVALUATION OF EXTENT OF NEO PLASTIC RISK OF VINYL CHLORIDE --POLYVINYL CHLORIDE E C. Hammond, Sc.D., American Cancer Soci ety, New York City, N.Y, 22. MOUSE TO MAN -- EXTRAPOLATION OF LABORATORY RESULTS TO HUMAN DISEASE M. A. Schneiderman, Ph.D., National Cancer Institute, Bethesda, Md. Discussion opened by: R. Doll, M.D., Oxford University, Oxford, England AS! 000015590