Document 0LoxnbM1111RNEj1BxEVaOw4V

August 1, 1969 Dr. J. B. Long Manager, Toxicology 3M Company 3N Canter St. Paul. Minnesota 55101 Dear Jimt Regarding your request ooncerning Aroclor^232Vl248. and 125^. I trust the following will aervc-your pur* Acute oral LD50 - rat - 4470 mg/kg Acute skin minimal lethal dose - rabbit - >1260 <2000 mg/kg. Although no skin or eye irritation studies were done, we know that the liquid Aroolors are good solvents for the normal fats and oils of the skin. Suffi cient akin contaot then could lead to drying and chapping. For this reason we recommend that re peated or prolonged skin oontaot be avoided. We do not have inhalation data. We do not have breakdown products slnoe these are relatively stable compounds. Aroclor 1248 Acute oral LD50 - Rat - 12.500 mg/kg Aoute akin minimum lethal dose - rabbit - >794 <1260 mg/kg. A study was made using a 4% (w/v) solution in com oil applied daily for 20 applications to the dipped lntaot skin of rabbits at doses of 10. 50. and 100 mg/kg/day. The 10 mg/kg/day dose had no effeot on body weight hematology and urine analyses when compared to the controls nor were there any gross or mlcropathologic findings. DSW 020323 STLCOPCB4008252 Dr. J. I. k_.ig August 1. 1969 Fags Two Aroolor^BB (Continued) The 50 mg/kg/day dose produced generalized Inactivity, weakness, lassitude, and loss of appetite. There were no significant loosl skin reactions. Hema tology and urine analyses were comparable to the controls. Cross pathologic examination revealed liver disooloratlon. All other tissues and organs were comparable to the controls. Micro pathologlo examination revealed moderate hepatic nearosls. All other tissues and organs were comparable to the con trols. The 100 mg/kg/day dose was more severe but comparable to the 50 mg/kg/day dose with regard to hematology, urine analyses, gross and micro pathologic examin ation. We do not have inhalation nor breakdown product data. Aroclor 1254 Acute oral LD50 - rat - 11,900 mg/kg Acute skin minimal lethal dose - rabbit - >1260 <2000 mg/kg. 20 Day Subacute Dermal - Rabbits Doses were 10, 50, 100, and 200 mg/kg/day. The LD50 was 75 mg/kg/day. No adverse reactions including hematology, urine analyses, gross or mloropathology, except after ten days sosllng and wrinkling of the skin, was observed from the 10 mg/kg/day dose. The 50, 100, and 200 mg/kg/day dose produced gener alized Inactivity, weakness, lassitude and loss of appetite. The 200 mg/kg/day dose produced death before adverse skin reactions were observed. At the 50 and 100 mg/kg/day levels, there were skin reactions which revealed scaling, wrinkling and fissures. At these doses there were no effeots on hematology or urine analyses. Gross pathologic examination revealed liver dis coloration. However, all other tissues and organs were comparable to the controls. OS M 020324 STLCOPCB4008253 Dr* J. I* ~-/ng August 1, 1969 Fag# Thr#t 20 Day Subacute Dermal Rabbit# (Continued) Microscopic examination r#v#al#d mod#rat# llvar n#oro#l#. However, all oth#r tlaaua and organa were comparable to the controls. V# do not have Inhalation or breakdown data for this product. Zf your weather has b##n anything Ilk# ours during July* you wouldn't ask such a silly question. Bast regards. Sincerely* William H. Hunt* Ph.D. Toxicologist* Medical Dept. iju DSW 020325 STLCOPCB4008254