Document 0LkE4gqG5dzEeZo4xBp71nLmn

which arc analogous to those observed in individuals diphtheria. Vladimir Kostka (|M; Mammalian Pathological Biochemistry, Section 12. ,rct synthesis of rat immunoglobulins--cell-free system for # jviithesis prepared from lymph-node microsomal vesicles , I8658j. lmmunochero. studies on Salmonella--detn. of " 1 (rf specific polysaccharide of Salmonella Strasbourg, ` " p, Salmonella (Sect. 2) 18799f. Topochem. arrangement `^jliosjdes in erythrocyte membrane (Sect. 2) 18808b. Jjuirtive study of reaction of heparin with hexammine cobalt and lysozyme (Sect. 2) 18724c. Ascorbic acid oxidase from different plant materials (Sect, 3) 19064*. Effect "s^wooe prepn. on protein fractions of immunised animal (Sect. 4) 19263p. Changes in body compn. during long- * utatment with cortisone and anabolic steroids in asthmatic (Sect. 4) 19188t. Simplified batch method for isolation " ^.glycoproteins from normal and pathological serums and wrt (Sect. 6) 19409r. Biol, activities of polyelectrolytically *.,, macromols. (Sect. 8) 1971 lh. ' Immunoelectrophoretic of antigenic components of Bacillus megaterium (Sect. i 8) 19757c. Sepn. and characterization of sol. adenovirus type 9 components (Sect. 8) 19716p. Structure and kinetics of forma tion of antibody in turtle (Sect. 0) 19946p. Difference in pro teolytic activity of spleen cells of young and immunologicaUy mature rabbits (Sect. 11) 20213d. Corticosteroid-binding globulin--biochemistry, physiology, and phytogeny (Sect. 11) 20)07x. Detection of embryo-specific globulins in serum of embryos and fulltenn human infants (Sect. 11) 20150f. Com parative immunoglobulin detns. in human serum (Sect. 11) 20178W. Sensitivity to some fungal allergens during penicillin prepn. (Sect. 14) 20587d. Role of histamine in production of immediate reactions of wheal and angioneurotic type (Sect. 16) 20S54p. Effect of some ganglion-blocking prepn*. on develop ment and course of anaphylactic shock (Sect. 15) 20830c. In fluence of chloramphenicol in immune reactinci in rats (Sect. 16) 20806a. Methodology and trends in study and prevention of sir pollution by chem. allergens (Sect. 50) 15779*. Antigen with nucleoside determinant (Sect. A3) 16099d. Fractionation of significant quantities of tool, active prepn*. by prolonged pre parative paper electrophoresis (Sect. 2) 1871 lw. Response of lymphocytes to penicillin; comparison with skin tests and circu lating antibodies in man (Sect. 15) 20706a. 14--TOXICOLOGY t. a. ToexamoN ,J0646Q Chemical analysis of aflatoxin. R. Monacelli and Study Drui Toxicity 8 93-106(l967)(Eng). The report sum i U. Manxone (Inst. Super. Sanita, Rome). Ann. 1st. Super. marize* the behavioral effects of anticholinesterases, and evalu j(pt. 3-4), 316-26(1967)(Ital). A review with 23 rrfer- ates the usefulness of behavioral methods for toxicological in Antonio A. Rizzoli vestigations with Para-oxon, parathion, Chlorthion, Systox ,-j$47r Toxicity of mercury vapor. G. A. Neville. Can. phosphamide, physostigmine, and galanthamine. 46 references. *-. Educ. 3(1), 4-7(1967)(Eng), A review is given of Hg P. S. Sarin .city, covering its history, threshold limits, mode of absorp- 20555* Neurotozic side effects of certain organophosphorus . *ud distribution, and treatments for Hg poisoning. 33 compound*. W. N. Aldridge and J. M. Barnes (Med. Council ,-tns. CRJN Labs., Carshalton, Engl.). Proc. Eur. Soc. Study Drug Toxicity M48* Fluorocarbon toxicity and biological action. J. Wes- 8 l62-8(1967)(Eng). A review of delayed neurotoxic effects i Clayton, Jr. (E. I. du Pont de Nemours and Co., Wilming- of some organophosphorous anticholinesterases. 20 references. ... 1*1.). Fluorine Chem. Rat. 1(2), 197-252(1967)(Eng). Jenifer A. Edwards ' i. eitrnsive review summarizes the known toxicology of the 2Q556t Biochemical and physiological causes of die toxicity t* .njlloines, the fluoroalkenes, and the fluoropolymers, and dis- of alcohol. Ryszaid Wiktor Schramm and Halina Schrammowa various aspects of their biol. action. Much more in- (Univ. A. Micklewicza, Poznan, Poland). Psyehiat. Pol. 1(3), >wuiiun is needed on the mechanism of action of these sub- 343-7(1967){Pol), A review with 47references. Y.Pomeran* * m. Understanding their mode of action in relation to their 20557u In vivo deiodination of Rose Beng*l-U1l in rats after constitution should be a governing factor in further m- administration of CCL. H. Bergner (Humboldt-Univ., Berlin). ". 4*1ions of fluorocarbon toxicity. 67 references. Ada Biot. Med. Get. 16, 294-0(1966)(Ger). About double the M, M. Judge amt. of uiI-labeled Rose Bengal was deiodinated in vivo in `W49t The effect of fluorides on livestock, with particular rats intoxicated by 0.1 ml. CCL/100 g. as compared with con wt-fence to cattle. James L. Shupe and Ernest W. Alther trols. With a protein-free diet, the effect was smaller and S. Agr. Res. Serv., Logan, Utah). Handbvck Exp. Pharma- could not be detected after 6 days. From CZ 1967(30), Abstr. t* 70(1), 307-54(1966)(Eng). A review of the effects of No. 1564. MZCR a mies on sheep, swine, horses, turkeys, and, esp. cattle. The 20558v Effect of acute and chronic hepatitis and of fatty liver cf-ru of fluorosis in cattle on teeth, bones, hair coat, skin, degeneration on erythropoiesis. B. Sari, S. V. Kirilina, Sh. soft tissue, kidney, liver, reproduction, blood, placental Dan, and L. Oros. .4eto Conv. Med. Intemae Hung., 3rd., ****/, milk production, digestion, metabolism, and enzymes Budapest 1965, 923-8(Russ). Rabbits were orally given 3 doses <h*cussed. A comprehensive guide for diagnosing and of 0.25 mg. CCl</kg. and then i.ra. 3 doses of 15 mg. phenyl- ** *-''ul,n2 fluorosis was given. 89 references. hydrazine (I)/kg. Consequently, plasma enzymes (alk. phos Patricia W. Heenan phatase, aldolase, glutamic-oxalacetic transaminase) increased, vlSOm The mammalian toxicology of organic compound! but erythrocyte enzymes did not change or slightly decreased. wtuming fluorine. J. Wesley Clayton, Jr. Handbuch Exp. After a few days, serum enzymes normalized and administration `--mckol. 20(1), 459-500(1966)(Eng). A review of mam- of I did not further alter their level. At the same time, erythro 40 toxicology, history, and uses of fluorocarbons, including cyte enzymes increased in activity due to I and the increase was * : wuxsion of the toxicology of fluoroalkanes, fluorocydo- correlated with the no. of reticulocytes. Later, these enzymes huoroalkencs, fluoroalcohols, and fluoroaromatic normalized as well, with the exception of glucose-6-phosphate " their acute and chronic inhalation toxicities, acute oral, dehydrogenase and aldolase, whose increase outlasted normaliza * u eye toxicities, and their biol. activities. 72 references. tion of the reticulocytes, indicating the presence of a large no. Patricia W. Heenan of young erythrocytes in the peripheral blood. These changes ~5In Botulism. Anton Skulberg (Forskningsutvalget were similar to those in erythrocyte enzymes in animals given ^ITTY?r-. Oslo, Norway). Norsk Pelsdyrblad 41(8), 25SH31 only I without CCL; it is concluded, therefore, that a slight ., ''orweg). A review of the subject in connection with acute injury to the liver does not affect erythropoiesis. Chronic ***** of poisoning of mink in Telemark, Norway, due to injury decreases erythrocyte survival time and accelerates "tniinnt] botulinum toxin in the mink feed. erythropoiesis. M. Kalab Valborg Aschehoug 20559w Poisoning with organic mercury compound* in the 75$2p Botulism in mink. Steinar Hauge, Anton Skulberg, Niigata prefecture along the Agano river. I. Detection of '* Ula Grini (Norges Veterinaerboegskole, Oslo, Norway). methylmercury compounds in hair of patients by gas chromatog '<4 Ptlidyrblad 41(18), 510-ll(1967)(Norweg). A review raphy. Yukio Takizawza and Takao Kosaka Fait., (Med. ,J* tnhject in connection with the recent cases of poisoning in Univ. Niigata, Japan). Acta Med. Biol. (Niigata) 14(3), 153-61 '*tms with CHoslrtdtum botuhnum in Telemark and Aust- (1966)(Ger). Eight patients exhibited poisoning attributable to 'Vt. Norway. As mink is an animal very sensitive to C. organomercury compds. Hair from the patients was treated ^ toxin, vaccination of the puppies should be recom- with detergent, water, HC1, CHClt, and dithizone before anal, ' > prophylactic means Valborg Aschehoug by gas chromatog. was carried out with a Shimazu GC-1C app. =hort term chemical danger. Georges Le Moan with electron capture detector (ECD-IA) with the conditions: ' Paris). Pkarm. Fr. 1967(16), 499-504(Fr). column 1.5 m., inner diam. approx. 3 mm.; column temp. " K given of the hazards of explosion, poisoning, etc., 190-5; 15 or 25'c diethylene glycol succinate on 60-80 mesh " * ol the precautions that should be taken against them, 'ri-nces. George M. Hocking 5Hr Neurotoxicity of anticholinesterase agent*. An- '-otic action of various centrally acting drugs. G. Bignami Sbimalite; N carrier gas at 35 ml./min.; detector temp. 200; sample size 0.5 al. Sepn. of methyl-, ethyl-, and butylmercury chlorides was achieved with the ECD-IA detector, but not by flame ionization. D. S. Plaut * L- Gatti (Ut. Super Sanita, Rome). Proc. Eur. Soc. 20560q Characterization of subtle toxicity of certain plastic ^ OLI 1684 lorcog 20561 Chamlcal Abstracts Vol. 68, 1968 P 14 components need in manufacture of the polyvinyls. W. L. Guess, Sol Haberman, D. F. Rowan, R. K. Bower, and John Autian (Univ. of Texas, Austin). Amer. J. Hosp. Pkarm. 24(9), 494-501 (1967)(Eng). The techniques useful in detecting the subtle toxicity of some ingredients used in the manuf. of poly(viny! chloride) plastics, used in the production of containers and closures for certain biologicals, are discussed. Methods of detection indude tissue culture tests, animal expts., and effects on antibody reactions and on washed blood cells. Certain heat stabilisers showed a marked incompatability with the biol. systems used. Reactions with 5 plastisizers were more subtle. The results suggest the need for further research into the relations between various levels of toxicity and potential harm in humans. H. M. Burlage 20561r Some chemical aspects concerning the occurrence of aliatoxin in foods and feeds. W. D. Raymond (Trop. Prod. Inst., London). An*. III. Super. Sanila 3(Pt. 3-4), 289-306 (1967)(Ital). This paper reviews various aspects of the problem aflatoxin in foods and' feeds. The agricultural, mycological chem., anal., biochem., toxic, com., and public health aspects of the problem are discussed. The presence of mycotoxins in foods and foods also is summarized. 47 references. Katherine H. Fisher 20562s The effect of diet on carbon tetrachloride metabolism. A. A. Seawright and A. E. M. McLean (Med. Res. Council Labs., Carshalton, Engl.). Biochen. /. 105(3), 1055-60 (1967)(Eng). Blood and liver conens. of CCL were measured at intervals after an oral dose, in rats given stock and protein- free diets. The values did not correlate with the resistance to poisoning found in the rats given protein-free diets. Metabolism of CCL to COi in vivo and in liver microsomal prepns. was de pressed in animals given protein-free diets. Rats given a single dose of DDT are highly sensitive to CCL poisoning. The livers of such animals had an increased microsomal protein content and greatly increased microsomal activity in the demethylation of Pyramidon and in the conversion of "CCL into "COi. The incorporation of leucine-14 C into protein by liver slices is de pressed by CCL- This effect is decreased by the addn. of SKF 525A and in slices from rats given protein-free diets. It is suggested that the toxicity of CCL is closely linked to its metabo lism. RCFG 20563t An attempt to influence the collagen defect in ex perimental lathyrism. K. Tmavsky, Z. Trnavska, B. Skrovina, and L. Cebecauer (Res. Inst. Rheumatic Diseases, Piestany, Czech.). Biochim. Physiol. Tissu Conjonctif, Con}. Common. Symp. Ini., Lyon 1965, 663-70(Pub. 1966)(Eng). To study the influence of hydrocortisone (I) and Na salicylate (Q) on the soly. of collagen proteins and on changes in the epiphyseal growth plates in lathyric rats, exptl. lathyrism was induced in 36 male rats by feeding a 60% concn. of sweetpea seeds (Lalkyrus odora- (ar) for 30 days. Twelve of these rats were simultaneously treated with I (10 mg./kg. body wt. daily), i.m.; another group of 12 were treated with II (250 mg./kg. daily), i.p. The 3 exptl. groups were compared with 3 nonlathyric control groups treated similarly. After 30 days, total hydroxyproline (III), dialyzable III, and acid-sol. Ill were detd. in dorsal skin exts. For histol. evaluation, the tibial growth plates from decalcified hind limbs were microscopically examd. Total III was not significantly changed in any of the groups studied. I in intact (control) animals resulted in decreased levels of the neutral saltsol. Ill and dialyzable m. II had no effect on the sol. fractions. Feeding with sweetpea increased the neutral and acid sol. HI; the greatest part of the lathyric neutral sol. fraction being dialyzable. In lathyric rats, I treatment depressed the elevated amts, of sol. m as well as dialyzable III. Even more effective in restoring normal conditions in lathyric rats was II treatment. Histol., the cells of the epiphyseal plate in lathyric animals showed elevated mitotic activity but delayed maturation. The synthesis of ground substance in the intercellular spaces was also disturbed with demasked collagen fibers, granular decompn., and some cystic areas. I depressed lathyTic toxicity, while II restored the tibial growth plate to nearly normal. 19 references. L. K. Allen 20564u Toxicity of 1,2-dichloroethane-extrmeted fish protein concentrate. I. C. Munro and A. B. Morrison (Food Drug Res. Labs., Dept. Natl. Health Welfare, Ottawa). Can. J. Biochem. 45(11), 1779-~81(1967)(Eng); cf. CA 67: 52842d. Wistar rats were fed a protein-free diet with 50% protein from lyophilized or extd. cod fish (lyophilized cod extd. for 24 hrs. with iso-PrOH or 1,2-dichloroethane (I), then heated for 2 hrs. at 60" in vacuo) which contained 4U mg. % chlorocholine chloride (II). Cod fillets extd. with I were toxic to the growing rat. The toxicity was not due to II but was coned, in a MeOH ext. of the I-treated fish. However the MeOH-extd. fish did not support growth even when supplemented with cystine and histidine. Dorothy J. Buchanan-Davidson 20565v Significance of carbon monoxide from cigaret smok ing inside a car. Milan Srch (Karlova Univ., Hradec-Kralove, Czech.). Deut. Z. Gesamte GerichU. Med. 60(3), 80-9(1967) (Ger). A forensic opinion from the author was needed in the case of a 30-year-old woman who had died in a dosed car wit> a garage. In a test on 4 persons, 2 of them smokers and 2 n smokers, who sat in a closed car with a cubature of 2.09 and smoked 5 cigarets with inhalation during 60 min., the C hemoglobin concn. in the blood of the smokers rose from .4 10%, that in the blood of the non-smokers from 2 to 5%. Un such circumstances a fatal intoxication was deemed not possil Consequences for traffic safety are discussed. D. H. Stofcu 20566w Histoautoradiographic studies on mesenchymal a duct cells of thioacetamidconduced cirrhosis of the liver in mi. Balthasar Wohlgemuth (Karl-Marx-Univ., Leipzig, Gcr Exp. Pathol. 1(1), 64-71(1967)(Ger). White mice (19-24 were fed 0.25-0.45 mg. thioacetamide (I) in the drinking wat. Controls without I were treated further by the same procedur. After 70 days`the animals were injected i.p. with 3 pci. of th> 1 dine (Hy-'H/g. body wt. After this the animals were b;; and the livers were fixed in HCHO; sections (5 0) were wav with inactive II to remove unincorporated II-*H, and autora! grams were exposed for 4, 6, 8, and 19 days at 15. After days the development of cirrhosis had proceeded widely m treated animals. The parenchyma was penetrated by reticu: and collagenous fibrillar structures as well as with tnesenchyi. and.duct cells, which increased in relative no. The incomer tion rate of Tl-'H into hcpatocytes increased from 0.03 (contr. to 0.24% in exptl. animals; in Kupffer's cells the resp. label; indexes were 1.67 and 2.41%. Labeling of hepatic capsule a endothelial cells or of the bile duct epithelium showed no r ference between controls and I-treated animals. The duct c< exhibited a labeling rate similar to that of Kupffer's cells ir. treated animals. As early as 1 hr. after II application, blacker, mitotic figures could be seen in Kupffer's cells, both in contr and in I-treated animals. A possible shortening of the ; phase due to unexplained reasons was considered. 34 referent. E. Talafant 20567x Histamine level and histamine fixation in the bra tissues and skin is rats under the effect of industrial poison R. S. Eizengart (Sanepidst., Moscow). Farmakol. Tokstk 30(5), 608~9(1967)(Rus$). Homogenates from rat brain a; from rat skin were tested chromatographically for histami concn. and histamine fixation after rats had been exposed eitl. to threshold concns. or to toxic doses of methylcyelohexsr ethylene sulfide, diethylaminoethyl mercaptan, or 2-methyl- vinylpyridine. At threshold levels there was less histami fixation in skin and more in brain tissue. After toxic dost the changes were irregular both in concn. and in histami fixation. Julian F. Smith 20568y The toxic peptides of Amanita phalloides. Theod Wieland (Gsethe-Univ., Frankfurt/M., Ger.). Fortsehr. Che Or[. Nature!. 25, 214-50(1967)(Eng). A review is given; fa< mushroom poisoning is almost exclusively attributable to mei bets of the genus Amanita. Their toxins are completely a sorbed from the gastrointestinal tract, while their action primarily on the liver; no specific therapeutic agent is known present. Thus, the understanding of the chem. structures 1 the mechanism of the action of the toxins is of great importu from the therapeutic standpoint. Isolation of the toxic gredients, the chem. structure of the toxic peptides, the pi loidin and the amanitin group, and synthetic expts. with an. acids and cyclopeptides are covered. 86 references. CSJ1 20569z Comparative toxicity of mercaptobenzimidazole . ite zinc salt. N. V. Mezentseva. Gig. Otsente a Khim. Fates Vnesh. Sredy 1966, 119-20(Russ). Mercaptobenzimidazole and its Zn salt (H) were studied in acute (mice), subacute (nr and chronic (rabbits) expts. LDh internally for mice was 1- for I and 737 mg./kg. for II. The animals were exposed t.' and Q dust for 2 hrs. daily for 15 days in concns. of 400 me m,* A lag in wt., increase in the content of amino N in t urine, and disturbances in the nervous system were observe Morphological alterations were found only in the lung tissue (p<- bronchitis with slight atrophy of the bronchial mucosa), chronic expts. on rabbits I caused disorder in the protein-for ing function of the liver. II increased the lipid content in t blood. I increased the aldolase content, and II decreased t cholinesterase activity of the blood. I decreased the erythroc\ count in the blood to 20,000. A proliferative reaction was fou in the lungs; edema and fatty dystrophy were observed in t liver, and punctate hemorrhages were observed in the m> cardium. Q caused slight edema in parenchymatous orgat I had no irritating effect on the skin or mucosa of the whereas II caused moderate irritation. From Ref.Zh.. Ftirn:.. Khimoterap. Sredsva. Tohsihol. 1967, Abstr. No. 7.54.531- m y k1.' 20570t Methods for the qualitative and quantitative termination ot aflatoxins. E. H. Marth (Univ. of Wucui Madison). Milk Food Technol. 30(10), 317-20(1967)1 Qual. and quant, measurements of aAatoxins by means of layer chromatog. can be improved by substituting a den- metric "reading" of the thin-layer plates for visual exa/ Examn. of small samples (down to 0.3 mg.) can be accompli' bv a thin-laver chromatoc procedure which emnlovv a