Document 0LLmOyYDOe5qG3xE5EkZJeadk

5-19-55 C. Steven s (2) a method o f e xt r a c t in g (from liv e r ) u n id e n t ifie d or gan ic i* Pb compounds formed by m etabolism of TEL in v iv o .. With t h ese m eth ods, i t appear s t h a t of 10 mgm. o f Pb in h aled as TEL by a r a t , 0 .5 mgm. can be r ecover ed as or gan ic Pb compounds from th e l i v e r a day l a t e r . Of t h at 0 .5 mgm., l e s s th an 0 .1 mgm. i s combined a s TEL. The rem ain der c o n sist s o f io n ic or gan ic Pb decom position produ cts of TEL. if , f1 These methods can be a n a ly t ic a lly in v e st iga t e d t o e st a b lish I t h e ir v a lid it y and lim it a t io n s, t o c la r ify t h e r eason s fo r t h e ir su c c e ss, o r t o exten d t h e ir u t i l i t y ". Or, th ey can be u sed t o a t t a c k qu est ion s such as t h e se : 1 . How i s TEL d ist r ib u t e d among var iou s t i ssu e s ? 2 . How lon g a ft e r exposure i s TEL t o be found in l i v e r ? 3 . What ar e th e decom position pr odu cts o f TEL in th e body ? in th e t e st tube ? 4 . Where ar e io n ic or gan ic Pb d e r iv a t iv e s of TEL lo c a lise d in th e body ? 5. At what r at e does TEL decompose in th e body ? in t issu e s l i c e s ? in t i ssu e homogenates ? 6. What ar e th e mechanisms o f t o x ic act io n o f th e decom position produ cts of TEL t h a t ar e produced in th e body ? 7 . How can t h ese a n a ly t ic a l methods be u sed in developin g pr oph ylactic (and cu r at ive) th erapy ? N 6624 6 0003467