Document 0JO8083EjjKEdr39ymmK868dM

CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE . POLYVINYL CHLORIDE AND STRUCTURAL ANALOGUES March 20-21, 1980 . National Institutes cf Health Masur Auditorium Building 10 Clinical Center Bethesda, Maryland Cosppnsors National Institutes of Environmental Health Sciences National Institute for Occupational Safety and Health Occupational Safety and Health Administration CTL030428 Thursday, March 20/ 1930 v 8:00 A.M. REGISTRATION 8:30 A.M. INTRODUCTORY REMARKS Dr. David Rail, NIEHS SESSION I - CARCINOGENESIS BIOASSAYS OF VINYL CHLORIDE MONOMER Chairperson: Dr. Umberto Saffiotti, NCI 8:45 A.M. 1. Carcinogenesis Bioassay of Vinyl Chloride Monomer with Particular Reference to Multiple Sites and Dosage Review Dr. Caesar Maltoni, Institute of Oncology and Tumor Center, Bologna 9:45 A.M. '2. Experimentally Induced Pulmonary Cancer Dr. Y. Suzuki, Mt. Sinai Medical School 10:00 A.M. Discussion 10:15 A.M. Break -- 10:45 A.M. 3. The Role of Aging on Vinyl Chloride Monomer - Induced Cancer Dr. David Groth, NIOSH 11:00 A.M. 4. Carcinogenic Effects of Exposure to Vinyl Chloride Monomer and Ethyl Alcohol on Rats Dr. Martha Radike, University of Cincinnati 11:15 A.M. 5. Cancer Induction Following Single and Multiple Exposures to a Constant Amount of Vinyl Chloride Monomer Dr. Robert Hehir, CPSC SESSION II -TOXICOLOGY STUDIES OF POLYVINYL CHLORIDE 11:30 A.M. 11:45 A.M. Chairperson: Dr. Peter Infante, OSHA 6. Pneumoconiosis in Animals Exposed to Polyvinyl Chloride Dust Dr. David Groth, NIOSH 7. Results of Carcinogenesis Bioassay of Polyvinyl Chloride Dr. Chris Wagner, BMRC, Penarth, Wales CTL030429 Thursday, March 20, 1980 SESSION III-SPUTUM CYTOLOGY OF VINYL CHLORIDE WORKERS Chairperson: Dr. Peter Infante, OSHA 12:00 P.M. 8. Results of Sputum Cytology Among Vinyl Chloride Polymerization and Polyvinyl Chloride Fabrication Workers Dr. Caesar Maltoni, Institute of Oncology and Tumor Center, Bologna 12:15 P.M. Discussion 12:30 P.M. LUNCH SESSION IV -MORTALITY STUDIES OF WORKERS EXPOSED TO VINYL CHLORIDE Chairperson: Dr. Philip Landrigan, NIOSH 2:00 P.M. 9. Multiple Site Risk Analysis of Vinyl Chloride Related Cancer in Workers - Review Dr. Peter Infante, OSHA 2:15 P.M. 10. Cohort Mortality Study of Vinyl Chloride Workers Dr. H. Weber, Der Staatliche Geverbearzt, Fed. Deutch Republic 2:30 P.M. 11. Epidemiological Study of Vinyl Chloride Workers Dr. Clark Cooper, Consultant 2:45 P.M. 12. Power Considerations in Epidemiologic Studies of Vinyl Chloride Workers Dr. Jay Beaumont, NIOSH 3:00 P.M. Discussion 3:15 P.M. Break SESSION V - LIVER AND BIOCHEMICAL CHANGES ASSOCIATED WITH VINYL CHLORIDE Chairperson: Dr. David Groth, NIOSH 3:45 P.M. 13. Epidemiologic Review of Hepatic Angiosarcoma in the United States Dr. Henry Falk, CDC CTL030430 Thursday, March 20, 1980 4:00 P.M. 14. United Kingdom Angiosarcoma Registry Dr. Peter Baxter, CDC 4:15 P.M. 15. Pathology of Vinyl Chloride Induced Liver Lesions Dr. Hans Popper, Mt. Sinai Medical School 4:30 .P.M. 16. Liver Screening Tests for Vinyl Chloride Exposed Workers Dr. Carlo Tambero, University of Louisville SESSION VI - INDUSTRIAL HYGIENE MEASUREMENTS OF POLYVINYL CHLORIDE OPERATIONS -Chairperson: Mr. James Gideon, NIOSH 4:45 P.M. 17. Polyvinyl Chloride Processes and Products Dr. R. Nick Wheeler, Union Carbide 5:00 P.M. 18. Characterization of Polyvinyl Chloride Homopolyme r.d- Additives Mr. Jay Jones , NIOSH 5:15 P.M. Discussion CTL030431 Friday, March 21, 1930 SESSION VII - MORBIDITY AND MORTALITY STUDIES OF POLYVINYL CHLORIDE EXPOSED WORKERS l Chairperson: Dr. R. Greenberg, University of Louisville 8:30 A.M. 19. Mortality Among Polyvinyl Chloride Fabricators Dr. Leonard Chiazze, Georgetown University 8:45 A.M. 20. Heart Disease in the Swedish Polyvinyl Chloride Fabricating Industry Dr. Gustavo Molina, Colombia 9:00 A.M. 21. An Epidemiological Study of Respiratory Disease in United Kingdom Workers Exposed to Polyvinyl Chloride Dust Dr. Anthony Seaton, University of Edinberg 9:15 A.M. oo .M. /V.i j -- Tv-'--*- i. Uxj V A.1AJT 1 viiXUX AUC i>uo u liiUU^UU Pneumoconiosis Dr. A. Arnaud, Marseille, France 9:30 A.M. 23. An Epidemiologic Study of Pneumoconiosis in the Italian Polyvinyl Chloride Industry Dr. Guiseppe Mastrangelo, Padova, Italy 9:45 A.M. 24. A Case-Control Study of Lung Cancer Among Vinyl Chloride-Polyvinyl Chloride Workers Dr. Richard Waxweiler, NIOSH 10:00 A.M. 25. Review of Pulmonary Effects of Polyvinyl Chloride Exposure Dr. Ruth Lilis, Mt. Sinai Medical School 10:15 A.M. Discussion 10:30 A.M. Break CTL030432 h Friday, March 21, 1980 SESSION VIII - REPRODUCTIVE EFFECTS OF VINYL CHLORIDE Chairperson: Dr. James Wilson, University of Cincinnati 11:00 A.M'. 26. Transplacental Teratogenic Effects of Vinyl Chloride in Experimental Animals Dr. Jackie John, DOW Midland 11:15 A.M. 27. Transplacental Carcinogenic Effects Dr. Jerry Rice, NCI 11:30 A.M. 28. Mutagenic Effects of Vinyl Chloride Dr. Jill Fabricant, University of Texas, Galveston 11:45' A.M. 29. Power Considerations in Studies- of Reproductive Effects Associated with Vinyl Chloride and Some Structural Analogues Ms. Maureen Hatch, Columbia UniverseLy 12:00 P.M. Discussion 12:30 P.M. LUNCH SESSION IX - ENVIRONMENTAL EXPOSURE TO VINYL CHLORIDEPOLYVINYL CHLORIDE AND LIVER ANGIOSARCOMA Chairperson: Dr. Pier Bertazzi, Institute of Occupational Health, Milan 2:00 P.M. 30. Fugitive Emissions of Vinyl ChloridePolyvinyl Chloride Speaker to be Announced 2:15 P.M. 31. Case-Control Study of Liver Angiosarcoma Among Residents in New York Dr. Nicholas Vianna, N.Y.S. Department of Health CTL030433 A h Friday, March 21, 1980 SESSION X 2:30 P.M. CARCINOGENICITY OF SOME STRUCTURAL ANALOGUES OF VINYL CHLORIDE Chairperson: Dr. Kim Hooner, University of California, Berkeley 32. Comparative Pathology of Vinyl Chloride and Vinyl Bromide Induced Liver Pathology in Animals' Dr. William Busey, Experimental Pathology Laboratories 2:45 P.M. 33. Review of Experimental Carcinogenesis of Vinyl Chloride Related Compounds Dr. Ken Chu, NCI 3:00 P.M. 34. Review of Epidemiologic Study Results of Vinyl Chloride Related Compounds Ms. Rosanne Apfeldorf, OSHA 3:15 P.M. Discussion 3:30 P.M. Break SESSION XI - RESEARCH NEEDS AND PUBLIC HEALTH INTERVENTION Chairperson: Dr. Anthony Robbins, NIOSH Panel Discussion: 4:00 P.M. 4:15 P.M. 35. Dr. Dale Haddis, Center for Policy Alternatives, MIT 36. Mr. Steve Wodka, OCAW 4:30 P.M. 37. Dr. Maurice Johnson, B.F . Goodrich 4:45 P.M. 38. Dr. Irving Selikoff, Mt. Sinai Medical School 5:00 P.M. 39. Dr. Joseph Wagoner, EDF 5:15 P.M. Discussion Proceedings from the Conference will be published. , \v CTL030434 Program Planning Committee Dr. Richard B. Everson NIEHS, Research Triangle Park, North Carolina Dr. Peter F. Infante OSHA, Washington, D.C. Dr. Philip J. Landrigan NIOSII, Cincinnati, Ohio Dr. Raymond E. Shapiro NIEHS, Research Triangle Park, North Carolina Dr. Richard J. Waxweiler NIOSH, Cincinnati, Ohio CTL030435