Document 0EerQ7jLqp67YDwOzBrX7Ymm

Z.4!> R ? V I p ? tSTVIU SM lD'SC ; E. du P o n t d e N e m o u r s & C o m p a n y IM CO rvrORATED W il m in g t o n , Dela w a r e 19898 POLYMER PRODUCTS DEPARTMENT EXPERIM ENTAL STATION p e r s o n a l a n d coi;fi s e ;;1:ia l 3. >'. Karr h L. J . Papa Pral File I.C. - K1I~ 00 - O9 4- & 2Z& - t/ January 6 , 195J LO: DR. Y L. POWER - PPL, Parkersburg FROM: S. S. STAFFORD AIIALYSIS OF BLOOD SAMPLES FOR PERFLUOF.OOCTAHOATE (Job Ko. 810-578; PRAL Nos. 8l-5W3-5*+6l;8l-5791-5308; ______Notebook Kos. E2251L,E26238,E27U32,E27^33 )______ As requested in your letters of 11/17 and 12/0l/8l to L. J. Papa, the 37 blood sar.pl.es subr.itted then have been analyzed for perfluorooctanoate (C-) by the usual gas chromatographic method ES-5c7- Results and sample identification are given in the attached table. Attachment ah Key Words: Per fluorooctanoate GC Blood Analysis There c,a world of llnnqs^ we re doina sorwthmg atroul 000183 EXP000074 EID 713888 TABLE I CONCENTRATION OF PERFLUOROOCTANOATE IN BLOOD (a) Sample PRAL No. 81-5H3 81-5444 0I-5I45 cl-5446 Sl-5117 61-5445 81-5II9 6I-3I50 61-5451 31-54-52 81-5153 8I-5I54 el-5155 6I-5I56 81-5157 81-5I58 5i-5l59 81-5I60 3 1 - 5I61 Date Sampled 11/-/61 1 1 /1/81 11/5/61 11/3/31 11/3/61 11/5/61 ii/b/6i 11/9/61 11/9/61 11/10/61 11/11/81 1 1 /1 2 / 6 1 11/12/dl li/12/il 1 1 /12/81 11/13/61 11/13/81 11/16/31 1 1 /16/81 P.R.No. v.s. 1829 3504 4527 441-, 4631 3659 W.S. 1510 1775 3669 W.S. W.S. 4706 3015 W.S. 3260 3506 3927 Name 81-5791 81-5792 81-5793 31-5794 81-5795 81-5796 81-5797 81-5798 81-5799 Bl-5300 81-5801 1 1 /1 7 /8 1 11/18/81 1 1 /1 8 /8 1 W.S. 3116 Pensioner <U98) 11/13/61 1 1 /18/81 1 1 /1 9 /8 1 3019 1*108 I5I5 11/19/81 11/19/81 1 1 /20/61 1 1 /20/61 933 llLi 3659 v:.S . 11/23/81 j. j GC Analysis ________________(b) Date Analyzed [Cr ] , PR F /p b l o o d 12/21/61 1 2 /9 /8 1 1 2 /1 1 / 6 1 12/11/61 -L * ^ 0. 2 .2 1 .-1 00 12/9 12/15/61 0.20 12/9 & 12/15/81 1 2 /9 /8 1 0.15 0.24 12/11/31 12/11/31 1 2 /9 /8 1 1 2 /9 /6 1 -"-2/11 & 12/io/5l 1 2 /1 1 / 6 1 12 /1 1 / 8 1 12 /1 1 / 8 1 1 2 /1 1 / 8 1 1 2 /1 5 / 8 1 1 2 /1 5 / 8 1 3.4 1.8 0.20 0.31 0.39 0.10 0.052 1 .6 0.12 0.26 C.0?4 12/ 11/81 0.31 1 2 / 15/61 12/25/81 12/15 & 12/21/81 0.25 0.16 2.5 12/ 15/81 12/15/81 12/16/61 12/15/62 12/1 C/S: 12/li/Sl 1 2 /iC/ei 1 2 /1 6 /8 1 0.23 0.11 0.6c 0.90 0.3' 0.14 O.It 0. ] 6 000184 REDACTED* EXP000075 EID 713889 TABLE 1 CONCENTRATION OF PERFLUOROOCTANOATE IN BLOOD (a0) Sample PRAL No. 61-5302 81-5803 Si-5801 51-5305 8l-5S0c 81-5807 81-5808 Date Sampled 1 1 /23/61 1 1 /23/Cl 1 1 /23/81 1 1 /21/Gl 1 1 /25/81 1 1 /25/81 1 1 /30/81 P.R.No. 1591 1625 W.S. V?.s . 1761 3281 1612 Name GC Analysis Date Analyzed 1 2 /16 /8 1 12/16/81 12/17/81 12/16/51 12/17/61 12/17/81 12/17/61 O O ro O O (b) [Cr ], vr F/r blood 0.19 0 .5; 0.02b 0.2c 0.43 81-1117 81-1836 81-3926 1 /6/81 1/27/31 8 /1 2 / 8 1 1111 1198 1631 12/15/81 12/15 & 12/21/81 12/15 & 12/17/61 0.16 (c) 2.8 (c) 0.17 (C.166, c (a) Analysis as described in Lab Method ES-567 ("Determination of Perfluorooctanoic Acid in Blood, Gas Chromatographic Method", S. Stafford, I4/3 /8 1 ), using the packed column GC analysis with perfluoro-n-octanoic acid as calibration standard. (b) Although the analysis is specifically for perfluorooctanoate (acid or salts;, concentrations are given in ppm fluorine for comparison with the results of total organic fluorine analyses. (ppm F = 0.633 x ppm perflnorccctanoic acid) Estimated uncertainty is 10% relative standard deviation. The lover limit for quantitation is 0.007 UgF/g. The detection limit is t 0.00b pgF/g, hut concentrations ir. that range cannot be well quantitated and are reported as < 0.007. Lone detected (n.d.) is reported for samples with [Cg] < 0.001 ppm, which cannot he distinguished from reagent background. (c) Previously analyzed samples, reanalyzed for comparison with repeat samples 81-5M 47, -5793, and -5bb8. Results of the initial analyses were; 5i-lll7, O.lS (1 /16/8 1 ); 81-1836; 2 .7 (5A / 8 1 ); 31-3926, 0.121 (9/1 1 /8 1). 0 0 0 1 SS REDACTED* EXP000076 EID 713890