Document 09nyny9Dagb0aB0Xa7ozbY8d

transplantation in a l2ycar-old patient with severe comllina! lmmunodifficiency.. N. EIigJ. 1. Med.,3/2(J8): 1151-1159, 1!f8S. 62. Levine, A.M. Lymphoma Complicating immunodeficiency disorders. Ann. Oncology, 5: s29-s35, 1994. 63. Purtilo, D.T., Tatstmrl. E., Mano!ov, G., Manolova, Y., Harada, S.., Lipsccmb. a, and Kruegc:r, G. Epstein-Barr Virus as an etiological agent in the pathogenesis of 1ymphoproliferative . '., and aprolifcrativ(l diseases in immune deficient patients. Tnt. Rev. Exp. Path., 27: 113-1 !l3, 19&5. 64. Kagami, Y., Nakamura. S., Suzuki, R.. Yatabe, Y.. Ok:w:la, Y.. Kobayasi, T:, Taniwaki, M., Seta, M., Ogura, M.. !lJ1d SuchL, T. A 1lOdn.! gammnld T-cell lymphoma with an association of Epste.inBarrvlrus. Am. 1. Surg. Pathol., 21: 729-736,1997. 65. McKnight. 1.LC., Ccn., H.. Riddler, SA, Breinig, M.C., Willimns, P.A, Ho, M., and Joseph. p.s. EBV gem: expression, EBNA antibody responses and EBV+ peripheral bloo;l. lymphocytes in post-transplant Iymphoproliferative disease. Leuk. Lymphoma, 1.5: 9-16, 1994. 66. Jones, J.P Shurln, 5., Abrmnowsky, C" Tubbs, R.R., Sciotto, C.G., WBhI, R.., Sands, J., Gottm1m, D., Katz, B.Z., and. Sklar, 1. T-cell lymphOlnas conllUning Epstein-Barr viral DNA in patients With chronic EpsteinBllITvitus infections. N. Engl. 1. Med., 318: 733-741,1988. 61. Su. t-1., Hsieh, H.-C., Lin, !c'-H., Uen, W.-C., Kao, C.-L., Cben, C.-l., Gbeng, A..-L., Kndin, M.E., and Chen, 1.-Y. Aggressive periphcraJ. T-cell lymphomas containing Epstein-Barr viral DNA: A clinicopathologic and molecular analysis.. Blood. 77: 799808, 1991. 68. Purtl1o, D.T. Epstein-bllTT-virus~induced oncogenesis in imrnune-dr::flcieru individuals. Lancet, 300-303,1980. 69. Jaske, D. and Knecht, H~ Ep.stein-Barrvirus in lymphomas: A review. Blood Rev., 7: 215222,1993. 70. Purtilo, D.T. and Stevenson, M. Lymphotropic viruses as etiologic agents of lymphoma. . Hematology/Oncology Clinics ofNortb America, S: 901923.1991. 71. De Vita, S., Sacco, C., Sansonno, D., Gloghini, A., Damma=, F, Crovatto. M, Snntini, G., . Dolcetti, R., Boiocchi. M., Carbqn\!,. A.; 1lD~ 0g11ne~ V. ~ctenzatJon of overt B-cdl . lymphomas in patients with.~e~~tis C.virus infection. Blood, 90: 776-78~,.1~~7. 72. Zuckerman, E., Zuekcn:nan, T.. Levin, A.M.. Dauer, D., Gutekunst, K., Mizokami, M., Qian. D.G.., Velanlau:, M., Nllthwani, B.N., and Fong, T.-L. Hepatitis C virus infection in patients with B-cell non-Hodgkin lymphoma. Ann. Intern. Med., 127: 423-42&., 1997. 73. Fern. C., La Civita, L, Monti, M., Giunnini, C., Cecchetti, R, Carac:cioto, F., LongQrnbardo, anaG., Lombardinl, F., Zignegn, A..L Chronic hepatitis C and !kell'non-Hodgkin's lyrnpl1oma. Q1M, 89: 117-121. 1996. 37 '" MOC00044349 74. Silvestri, F., Barillari, G., Fanin. H.. Pipan, C., Falasca, E., Salmasa, F., Zaja, F., lnfnnti, L., Patriarca, F., and Botta, G.A. The genotype (lethe hepatitis C virus in patients with HCV-related B cell non-Hodgkin's lymphoma. Leukemi~ JJ: 11?7-2161, 1997. 75. Zignego, A.L., Macchia, D., Monti, M., Thien, V., Mazzetti, M, Foschi, M., Maggi, E., Rc'Illl!gIl!l.IIi, S., Gcntilini, p.. and Brcchot, C. lnflKltion of pcriplu:ral mono[luclear blood cells by hepatitis C virus. Journal ofhepatoiogy, 15: 382-386, 1992. 76. Lee, S.-H., Su, I.-I., Chen, H.-L., Lin, K.-S., Lin, D.-T., IUld Chuu, W.-M A pathologic study of childhood lymphoma in Taiwan with special reference to peripheral T-cell lymphoma and lhcassoc:ialion with Epstein-Ban-viral infectioo.. CaDcer, 68: 1954-1962.1991. ' 77. Canmwota, G., Tursi, A., Mantalto, M., Pllp<!, A, BI1illC8, 0., Vecchio, P.M., Renzi, C., Verzl, A., Armuz:zi, A.. Preto\ani, S., Fedeli, G., a.o.d Ciusbnrrini. O. Prevention and treatment of lOW-grade B-cell priroaty gastric lympboma Jiby anti-H.Pylori therapy. I. Clin. Gastroc:ntcroI, 21: 118-122, 1995. . 78. Bayerdorffcr. E., Neubauer, A., Rudolph, a., Thiede, C., Lebn. N., Edt, S., and Stolte, M. Regression of primary gastric lymphoma. of mucosa-associated lymphoid tissuo type after cUre of Hdicobar:ler pylori Infeatioo.. Lancet, 345; 1591-1594, 1995, 79. Dogliooi, C., Wotherspoon. A.C., Moschini, A., De Boni, M... and Isaacson, P.O. High incldence ofprimary gastric lymphoma in nortlu:a.stt:m Italy. Lancet, 339: 1134-835, 1992.. 80, Eck, M-, Schmauber, B., Haas, R., Greiner, A., Czub, S., and Mul1cr-Hcrinelink. H.K. MALT-type lymphoma of the stomanh is lISSOCiated with He{icnbar:ler pylori strains expressing the Ca&A protem.. Gastroenterology, 112: 1482-1486, 1997. 81. Forman, D., Silas, P., Newell, D.O., Stacey. A.R.., Borebnrn., I., Peto, R., Campbell. T.C., Li. J.. and C~n, I. OeogtaphU: association of Helicobar:ter pylori antibody prevaleoce and gas\:Jic cancer mortality in rural China.ln1. J; Cancer, 46: 608-611, 1990.' . 82. Walt, R..P. IU:.gression of MALT lymphoma and treatment for Helicabacter pylori. Lancet, 348: 1041-1042, 1996. . 81.. Tatham, L., Tolbert, p" an.d Kjelclsberg, C. Occupatio.nal risk fa,clon; for subgroups of non::. Hod~'s Iyrnp?o~ ~idemiology. 8: ~Sl-55g.1.~~7, ... . .. . . .. &4. Harris, N.L., Jaffe, E.S., Sldn, Il, Banks, P.M., Chan, J.K.C., Cleary, M.L., Del501, G., De WolfPeeters, C., Falii:d.. B., Garter, K..C.. Grogan, T.M., Isaacson. P.O., Knowles, J:).M. Mason, D. Y., MuUer-Herntelink, H.-K.., PUen, S.A.. Pins. M.A., RalIkiacr. E~ II.!ld WI!I'Ilke, It.A. A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group. Blood, 84: 1361-1392, 1994. 38 MOCQ0044350 85. Ide, ES, Harris. N.L., Diebold, J., Il.!ld Muller-Hennelink. H.K. World Health Orgll.'lli:z:ation clessifica.t:ioQ of lympholIUlS: A work in progress. Ann. Ducat.. 9 Suppl: S25-S30, 1998. 86. Koeppen, H. and Vardiman, l.W. New entities, issues, and controversies in the classification of malignant lymphoma. Sonin. Oncol., 2$: 421-434, 19911. 87. Hanington, D.S., VII, Y.. Weisenburger, D.O., Annilage, 1.0., Pierson, I., Bast. M., and PurtiJo, D.T. Malignant lymphoma in Nebl'llSb and GWIllgzhOU, China. Hum. PaJ.l:Jol, 18: 924928. 1987. a~~~~~~~~~~~~~~~~ S.-W. REAL classification of malignant lymphomJlS in the RJ:pubuc of Korea: IncidenCl! of rw::ntly recognized entities and changes in clinicopathologic features. Cancer, 81: 806-811, 19911. 89_ IniragumtDmchai, T., WlIllW.lknUroj, P., Chaimoogkol. B., Bhoopat., L., LekhakuJa, A., Thamprasit. T., SUWlIIlWC\a, N., Suthipinthawong. C., Prayoonwiwat, W., Meek:ungwo:l, P. Sirijer.mbai, C., and Pa:irojlrul, C. Non-Hodgkin's lymphoDlllS in Thailand: A retrospa:tive pathologic and clinical ana\ysi& of 1391 cases. Cancer, 78: 1IU3181~, 1996. !il(). Yang. K. A histopathologic and immunopathologic study of 209 malignant Jymplunna ca!lgiODS ofChlna: Suzhou, Nanjing, Qinlrdao and Shcnyang. Chung HuaChung Liu Tsa Chih, }5: 85-90, 1993. 91. Klein, G. and Klein, R Sinking surveillance's flagsbip. Nature, 395: 441-444,1998. 92. Nilsson, K. and Klein, G. Phenotypic and cytogenenc chanicteristics of human B-Iumpboid cielliines and 1heirrclevance for the etiology of Burkitt's lymphoma. Adv. Can:er Res., J 7: 319 3110,1982. 93., Cbmlg. K..L. and Weiss. L.M. The association of the, Epstein-Barr virus with m.alignant lymphoma. Biomed. Pharmacothcr., SO: 459-467,1996. 94. Chan. J.K.C., Tsang, W.Y.W., Ng. C.S., Wong, C.S.C., and to, E.8.F. A study of the association of Epstein-Barr virus with Burkitt's Iymph~ma occurring in a Chinese population. ,Histopathology, 26: 239-245, 1995. . , ,.. . 95. Quintauilla-Martlncl., L.. Lome-Maldonado, C., Ott, G., Gschwendtncr, A., Gredlcr. E., Reyes, E., Angeles-Angeles,'A., and Fend, F: PririliIy non.Kodckin's lymphoma'Of the intestine: High prevalence ofEpstein-Bart virus in Mexican lymphomas as compared with European cases. Blood, 89: 644-651, 1997. ,96. Wolvius, E.B., liwa, N.M., van del VaIk. P., Horstman, A., II.Ild van dec Waal. E. Adcnolyrnphoma and non'Hodgldn's lympboma of the salivary glands and oral cavity in immunocompetent patients are not associated with latent EpsteinBarr virus. Oral Oncology, .H: [(9-, 23, 1991. 39 MOC00044351 97. Elenitoba. K..SJ. Zarate-Osoroo, A., Meneses, A., Krenacs, t., IGngrn.a, D.W., Raffeld, M., and Jaffe, E.S. Cytotoxic gIaIluIar protein expressi(ltl, Epstein-Barr virus strain typC!. and latent membrane protein-1 oncogeoc deletions in nasal T-Iymphocyte/natural killer cdI. lymphomas from Mexico. Mod. Pathol., II: 754-761, 1998. 98. Ohsawa, M. Nakatsuka, S.-t, Kanno, H" Miwa, H., Kojya, S., Harabuc:hi, Y.., Yang, W.-l, and Aozasa.. K.. Immunopheootypic and genotypic cbarncterizn.tioll of nasa[ lymphoma with polymoIpruc reticulosis mOIpboiogy.1nt J. Cancer. 8/: 865870. 1999. 99. Wu. S,-J., Lay,l.-O'1 Chen. C.-L.. chen. J.-Y., Liu. M-Y. a.nd So. L-J, Genomic analysis of Epstein-Barr virus in nasal and pcripbcmJ T-cell lymphoma; A comparison with nasopharyngeal cm;:inoma in an endemic an::a.. JMed Viral, 50: 314-321, 1996. 100. Buh,J... Cho, K.., Heo, D.S., Kim, r.E., aru1 Kim, C:W. Detection of Epstein-Barr virus in Korean peripberal T-eelllymphoma. Am. J. Hematol., 60: 205-214, 1999. 101. Clmn, J.K-C., Yip, T.T.C., Tsang, W.Y.W., Ng, e.s.., Lau, W.H., Poon. Y.F., Wang, C.C.S., and Ma.. V.W.S. Detection of Epstein-8m vim! RNA in. malignant lymphomas of !he upper . acrodigestivc tract. Am. J. Surg. PllthDl., 18: 938-946, 1994. 102. Ha, F.C.s., Srivastava. G., Loke, SL., Fu, IC.H., Leung. B.P.Y., Liang. R., and Choy, D. Presence ofEpslcinBarrv~ DNA in nasallympholllf!.S ofB .and'T' cell type. HcmatoL Oncol., 8: 271281.1990. . 103. Hambuchl, V.. Imai, S., Wakashima, J., HiI:lllJ, M., Kataura., A., Osalo, T.. a.nd Ken, S. Nasal T-cell lymphoma causally associated with Epstein-B= virus. Cancer, 77: 2137-2149. 1996. . 104. Cheng, A.-L., Su, L-1., Chen, Y...c~ Ucn, W.-C., and W.ang, C.-H. Cbarac!t!rlstic clinicopathologic features of Epstein-Barr virus-associated peripberal T-cell lymphoma. Cancer, 72: 909-916, 1!f93. 105. Zhou, x.G., Hamilton-Dutoit,. SJ., Yan, Q.H.. and Patlesen, G. High frequency of Epstein~ Barr virus in Chinese periphcra! T-celllympbarna. HistopatholDgy, 24: 1[Sl22, 1994. tvr.,106. Abdel-H.amid, M, ..cb~n, J.-I., Constantine, N., Ma.sso~~, and Ra.a.b-Traub, N. EBV strain variation: Gwgraphlca1 distribution and relation to disease slate. Virology, 190: [68175, 1992. .. _. . . ,- ... .. le1. Lung. M.L., Chang, &.8., Huang, ML., Guo, H.-V., Cho,)" D., Sham, J., Tsao, S.-Y., Cheng, P. .and Ng, M.N. Epstein.Sarr virus genotypes ll5Sociated with nasopharyngeal carcin()Jna in Southcm China. Virology, 177: 44-53, 199C. 40 MOC00044352 108. Chen, X., Pepper, S..cie V.. and Arrand, 1.R. Prevalence of Ihe A IlIld B types of Epstein- Barr virus DNA in nasoph:UYngcaI carcinoma biopsies from southern Chlna. J Gen Viml. 73: 463-466, 1992. . 109. YWlJ1, J.-M Govindarajan. S Henderson., a.E. IlIld YU, M.e. Low prevalence of hepatitis C infection in hcpatoccUular carcinoma (BCC) cases and population controls ill Guiulg:Jd. a hyperendemic region for HCC in the People's Republic of China. Br. J. CanCer. 7-1; 491..493, 1996. 110. Wu, R.-R., Mizokami. M., ClIO, K Nakano, T., Gc, X.-M., Wang, S,-S. Orito. 8.. Ohba, K.-I.. Mukaide. M., Hikiji, K., Lau, J.Y.N., and lino, S. OR virus Clhepatitis G virus'infection in southern China. Jo1lllllll of Infectious Diseascs,175: 168-171. 1997. 111. Suzuki. K.. Miwkami, M. Cao, K... Wu, :x.-S. Wu, R.-R., Hata, A., Sasaki. M.. Fang, Z. x., Zhang. L.-Y.. Lan, J.Y.N., and lino, S. Prevalence of hepatitis C virus infection in NlIlljing, Southern China. Eut'ope3ll Journal ofEpidemiology, 11: 51 t-5 I5, 1997. 112. McColl, M.D., Singe:r, 1.0., Tad. R.C McNeil. I.R.R., Cumming, R.L.C. and Hogg. R.B. The role ofbcpatitis C virus in the aetiology ofnon-Hodgkins lymphoma-A regional associatioD.? Leuk. Lymphoma. 25: 121-130.1991. c..11.3. Mazzara, Zag(JIle~ V., Mtmfardini, S., Tulissi, P., Pussini, E. Fanni, M. Soria, R.. Bortoius, R.. Croval.1D, M., Santini, G., T'aribelli, C.. Sasso, P., Masutti, R.. and PozzatD, G.. HepBiiti:l C virus and noD-Hodgkin's Iymphomus. Br. J. Haematol., 94: 544-550. 1996. l14. Ohsawa,. M., Shingu. N., Miwa, H Yoshih.ara, H. Kubo, M., Tsukuma, H.. Tesbi.ma, H Hashimoto, M.. and Aozasa, K. Risk Df non-Hodgkin's lymphoma in patients with hepatitis C virus infection. lot. J. Cancer, 80; 237-239, 1999. ItS. Vallisa., D.. Berte, R., Rocca, A" Civw:di, G., Giangregorlo, F., Fcnari, B.,SboUi, G. and Cavanna, :L. Association between lLaPatltis C virus and Non-Hodgkin's lymphoma, and effeots of viral infection an histologic: :rubtype and ciinical cour.se. Am. J. Merl., }06: 556-560, 1999.. I Hi. A1va:m. T., Bosch, R., SaIvado, M.T., and PUis, M.A. True hlstioc.ytic lymphoma of the stomach IISsociated with low-gru.de B-cell mucosa-associated lymphoid tissue (Malt)-type lymphoma. Am. J. Surg. Pathol., 20; 14061411, 1996. . 117. 0:;Cammarota, G.. Tursi. A.., Montalto, M., Papa, A., Veneto, G., Trua, F., Addolorato, Verzi, A., Certo, M.. Cuoco, L., Branca:, G.; Fedeli, !l., and Gasbw:riui, O. Clinical asseSsment of the relationship ofHelicdbacter pylori to gastroduodenal pathologil:S. Panmi.nerva Med., 37: 178- un, 1995. Itit Catnrnarota, G., Tursi, A. Papa, A., Vasa, M.T., Sew&!, F., ChlUSQl0, P., Fedeli, 0'1 md Gasbanini, O. Tbl'l growth of prim:ll}' low-grade B-cell gastric lymphoma is sustained by Hel1cabacter pylori. Scand. 1. Gastroente.rol., 32: 125287. 1997. 41 Mocoa044353 119. Carlson., SJ., Yo\coo, H.t and Vanagunas, A. Progression of gastritis to mODocloo.a! B-ceU lymphoma with l1!lSOlutien and recurrence following eradication of He:/ieobac/el' pylarl. lAMA, 275: 937-939. 1996. 120. Chan, I.LC. Gastrointestinal lymphomas: At. overview with emphasis on new findings and diagnostic problems. SeLDin. Diagn. PathoL. }3: 260296, 1996. 111. So1cia, E., Fiocca, R.. Luinetti, 0., Villani, L., Padovan, L., Calisiri., D., Ranzani, G.N., CbiaravaDl, A., IlIlli Capella.. C. Intestinal and diffuse gB$1rlc cancers arise in a different backgrolmd of Helicohacler pylori gastritis througb diffcrent gene involvemcnt Am. J. Surg. Pallial, 20: SaS22. 1996. 122. Martin, J.t Boyle, S.,l!Od ]1IDj'1la.. M. Regressioll of a large gastric MALT lymphoma with antibiotic tteatm=nt to eradicate Helicobacter pylori. postgrad. Mild. 1., 73: 109-110, 1997. 123. Vanagunas.. A. Eradication of Relicabaerer pylori and regression of B-cell lymphoma. Biomed. Pharmacother., 51: 156-160, 1997. 124. [ARC Monographs on the: Evaluation of carcinogenic risks 10 humans: Infection with .'. Relicobacter pylori. IARC, 0/: 177-241, 19~4. 125. HoUstcin, M., Sidransky, D Vogelstein, B., and Harris, C.C. p53 mu!a1ions in human caIlcctS. Science, 2iS: 4953,1991. 126. Hm:ris, C.C. 1995 Deiohm.ann Lccture-pS3 tumor suppressor gene:: at the crossroads of molecular c:an:inogenesis, moJecullll' epidemiology aru:I cancer risk assessment Tomeol Lett, 8283: 1-7.1995. 127. Kleibues. P., Aguzzi, A., and Ohgaki, H. Genetic aru:I environmental factors in the etiology pfhuma.n brain tumors. Texicol. Lett,82-8:1: 601-605, 1995. . 12K. 1..0 Coco, P., Grud!i:no, G.. Louie, D.C., Offit. K., Cbagimti, R.S.K., and DaIlaFavCIa,. R. pS3 mutations .M: llS50cinted witb histologic Il:lInSformation of fonicular lymphoma. Blood, 82: 22K9-2295, 1993. 129. Bhatia, K.., Go[dschmidts. W., Gutierrez, M., Gaidano, G., 'Oalla-Favera, R., and Magrath, I. Hemi-or homozygosity: a requirement for some but not other p~3 muta}lt. proteins .to -ll.ccumuiate and exert a pathogenetic effect. FASEn J., 7: 951-956., 1993. no. Oka, T., Sarker, A.B., Teramola, N., Yoshino, T., and A.kagi, T. p53 protein expression in non-Hodgkin's lymphomas is infrequently related to p53 gene mutations. Pathology International,48: 15-21.1998. 131. Clodi, L, YOIl.tleS. A,., Goodacre, A., R.oberts, M. Palmer, J., Younes, M... Cahanillas, F., and Audrt:c.ff, M. Analysis of p53 geue; de.letiuus in patients with non-Hodgkin's lymphoma by dua!-colour fluoresceneinsiw hybridi7Ation. Br. 1. Haematol., 98: 9L3-921, t997. . 42 MOC00044354 132. Cben, P.-M.. Chiou. T.-l., Hsieh. R.-K., Fan, F.S., ChI!, C.-J.. Un, C.-Z.., Chiang, It., Yen, C.-C., Wnag, W.-S., and Liu, 1.-H. p53 gene mutations and rearrangements In non-Hodgkin's lymphoma, Cancer, 8$; 718724, 199!1. 133. Koduru, P.R.K.. Raju. K., Vadmal, V~ Menezes, G., Shah, S., Susin, M., Kolin, J., IUld Broome, 1.0. Correlation between mutation in P53, p53 expression, cytogenetics, IWllologio type, and survival in patients with ~U non-Hodgkin's lymphoma. Blood, 90; 4078-4091, 1991. 134. Moller, MB., Ino, Y., Gerdes, A.-M., Sigodt, K., Louis, D.N., and Pedersen. N.T. Aberrations 'of the p53 pathway components p53, MOM2 and CDKN2A appear independent in diffuse large Bcelilymphomll.. Leukemia, ! J: 453-459, 1999. 135. Ncri, A., Baldini, L., Tr=a., D., Crn, L., PoUi, E., lind Maiolo, A.T. p53 gene mutations in multiple myeloma are associated with advanced foons of malignancy. Blood, 81: 1211-135, 1993. l36. Prcudhomme, C..., Pacon, T., Zandecki, M., Vanrumbeke, M., Lal, 1.r:... Nataf', E.., Loucheux~ Lefebvre,M.H., Kerckaert, 1.P., and Fellll.llX, P. Rare occum:nce of p53 gene mutations in multiple myeloma. Br. J. Haemarol.. 81: 440-443, 1992- 131. YlI.SlJgI, Y", Hirosawa. S.. Yamamoto, K.. Tomiyama, I., Nagata, K.., and Aokia, N. Nras nod p53 gene mutations are very Il1l"C events in multiple myeloma. International Journal of Hematology, 62; 91-97. 1995. 138. Wada, M.. Belram, C.R., NWtamWll., H., Hachiya, M., Chen, D.-L.., Borenst!:in, I., Miller, C.W Ludwig., L.,Hansen-Hagge, T.E., Ludwig, W.-D., Reiter, A., Mizogucbi, H., and Kaeffier, H.P. Analysis of pS3 mutations .in a !arge: series of Iympboid hematologic IIlIIllgDllllcies of childhood. Blood, 82: J 163-3169,.1993, 139. Kipell, H.M.. Cody, R.P.. Crump. K.S... Allen, B.C., lUld Goldstein, B.D. Hematologic effeclS of benzene: a thirty-five year longitudinnl study of rubber workers. Toxicol Iad Health, 4(4): 411-430, 1988. . 140. Momose.. H., Jaffe, E.S., Shin,. 8.S. Chen, Y.Y., and Weiss, L.M. Chronic Iympbocytic leubmtia1small lympbocytic lymphoma with Reed-Sternberg-like cells and possible trallsfonnation to Hodgkin's disease. Am. J. Sorgo I>at}tq~,J: 859-867, 1997. 141. Tsai, S.P., Wen, C.P., Weiss, N.S., Wong, 0:,' McClellan, W.A., and 'GibsOn, R.L. Retrospective Monality and Medica.l Surveillance Studies o( Workers in Benzene Areas of Rdineries. I. Occup. Med.. 25(9): 585-692, 1983. 142. Rotlmian, No, LI, G.-L.. Do~rncci. M., lkcbiold, W.E., Marti, G.E., Wang. Y.-Z.t Linct. M., Xi, L., Lu., W., Smith, M.T., TitcnkoHolland, N.. Zhang, L.-P., Blot, W., Yin, B.-N.. and Hayes, R.B. Hematotoxicity among Chinese warkeis heavily el{posed to \;Cozen!:. Am. J. Ind. Med., 29: 236-246,1996. 43 - - - - - - - - -_ _ _ _ _ _ _ _ _ _........c_. _ _ _ _ _ _ _ _ . _ _ __ MOC00044355 143. RothmM., N., Smith, M.T., Hayes., R.B., Ii. G.L., Irons. R.D., Dosemcci, M., Haas, ll, Stillman, W..s., Linet, M., X~ L,Q., Bechtold, W.E., Wlemels, I Camplem.an. S" Zhang. L,P., Quintana, P.J.E., TitenkoHolland, N,. Wang, Y.z. Lu. W., KolachanB, P., Meyer, K.B., and Ym, S.N. An epidemiologic study of early biologic effects of benzene in ClUncse workers. Environ. Health Perspect,lD4Suppl. 6: 13651370, 1996. 144. Zhang, L.P., Rothman, N., Wang. y.x., Hayes., ItB., Bechtold, W.o Venkntesh, P., YIn, S.N.. WMg, y.z., Dosenw::i, M., Li, O.L., Lu, W.. and Smith, M.T. Interphase cytogenetics of workers exposed to beOZCIlC. Environ. Health Perspeet., 104 Suppl. 0: 1325-1329, 1996. 145. Bennett, J.M., Catovsky, D., Daniel, M.T., Flandrln. G..., Galton, D.A.G.,Gmlnick, H.ll, and Sultan, C. Proposals for the classification of the myelodysplastic syndromes. Br. J. HaemafDl., 51: 189\99,1982. 146. Cheson,. B.D., Cassileth, P.A., Head, D.ll, Schiffer, C.A., Bennett, I.M. Bloomfield, C.D., Bnmning, ll, Gale, llP., Grever, M.ll, Keating, MJ., Sawitsky, A.. Stass, S., Weinstein, H.t and Woods, W.O. Report of tile NatiomU Cruiccr Institutesponsored workshop an definitions of diagnosis and response in llCute myeloid leukemia. 1. Clin. Onrol, 8: 813819, 1990. 147. Bennett, 10M., Catovsky, D., Daniel, M.~T. FlaIldrin, G., Galton, DAG., Gmlnick, H.R., and Sultan, C. Proposals for the classification ofthe acute hmkaemias. Br. 1. Hll.CII1l!toL. 33: 451- 458,1976. 148. Bennett, 1.M., Catllvs!cy, D., Daniel, M.T., PlaIldrln, 0., Galton, DAG., Gra.lnick, H.lt, and Sultan. C. Proposed revised criteria for the classification of lICute myeloid leukemia. Ann. Intern. Med.. 103: 626-629, 1985. 149. Third MIC Cooperative Study Group, Recommendations for it morphologic, immnnologic. and cytogenctiCl (MlC) jworking classification of the primary and therapy.related myclodysplastic disordCtli: Report of the workshop held in Scottsd:!.le, Arizona, USA, on February 2l~25, 1~87. Cancer Genet. Cytogcncl, 32: )10, 1988. 150. Bennett, I.M. Secondary acute myeloid leukemia. Leak. Res" 19: 23 J-232, 1995. 15... VllI'diman,"J.W., Coelho, A., Golomb, H.M., and Rowley, J. Morphologic and cytochcmh:al observations on the overt \eukellJi.c plwse,of .therapyrelate~ leukemia. f>I!!. !. Glilt- Pat/"loL. 525- 530, 1983, ., 152.. OM, A., Cattoretti. 0., Soligo, D., LukscIt, It. and Lambeneoghi-Deliliers, G. Therapy~ related myeJodysp!astic syndromes: FAB olas.s1ficalion, bone marrow histology, l!Ild immunohistology ofthe prognostic assessment. Leukemia, 7:' 838-847, 1993. 153. Estey, E.a, Kea.ting,M.l, Dixon, D.O Trujillo, J.M., McCredie, K.B., and Freireicb, E.J. Karyotype is prognostically more important than the E' AB system's distinction between myelodysplastic SYlldrom~ and lIeute myelogenous lcula::mia. Hc:matol. Pathol~ 1: 203-208,19117. 44 MOC00044356 154. Bam, BJ. LeukacmiaDiagnosis. p. 1. Malden: Blackwell Science, 1999. 155. Pugh, W.C., Pearson, M.N., Vardiman, J.W., and Rowley, 1.0. Pliiladelphia ChromosomeNegative Chrtmic Myelogenous Leuk:a.ernhl.: A Morphological Reassessment. Sr. I. HlI.CmaiOl., DO: 457-467, 1985. 156. Van Lom, K., Hagt:JDeijer, A., Vandekerekhove, P., De Greef; G.E., Sanrlli. N., and LDwen'berg, B. Clonality analysis of hematopoietic cell lineages in acute myeloid leukemia and translocation (8jll): Only myeloid cells arc part of the malignant clone. Leukemia, II: 202-205, 1997. 157. Hussey, C.E~ Lyon. E. MillsoR, A., Lay, MJ., Wittwer. C.T., and Segal, G.H. A rapid practical RT-PCR-based approach. for the detection oftbe PMLlRARalpha fusion transcript in acut:c promyelocy11c leukemia. Am. J. elin. Palhol., J12; 256-262. 1999. 158. Seckcr-W8l\cr::r, L.M.. Moorman. A.V., Bam, B.1., and Mebta, A.B. Secondary acute leuk:cmirI. and myelodysplastic syndrome with llq23 ahnor:m.alities. Leuktmia, 12: 840-844, 1998. x..l59. Poirel. H., Rack, R., Delabesse, E.., Radford-Weiss, 1., TroU,5sard, Debert,C., L:boeuf, D., Bastard, C, Picard. F.. Veil-Buzyn, A., Flandrin, G., Bernard. 0., and Macintyre, E. Incidence and characterization oC MLL gene (11q23) I1:lImIDgements in acute myeloid leukemia Ml and MS. Blood.. 87: 2496-2505,1996. 160. Rash-Traub, N. and Flynn, K. The structure of the termini of the Epstein-Barr virus as a lIIIIl'ker ofclolllll cellular proliferation. Cen, 47: 883-889. 1986. 161. Moore, p.s., Kingsley. L.A., Holmberg, SD., Spira, T Gupta, P., Hoover, D.R., Parry, I.P., Conley, L.t, Iaffe, H.W., and Chang, Y. Kaposi's SllI'Coma-assoclated herpesvirus infection prior to DllSct of Kaposi's sarcoma. AIDS, 10: 175-180, 1996. 162. Sa.wada, K.. Sato, N., Nataya, A., Tarumi, T., Himyama, S. Takano, H., Koivuol, K., Yasukoucm. T., Y!II:IIIIg!.IChi M, and Koike, T. Proliferation. and differentiation of mye!odysplastic CD34+ cells: Phenotypic; subpoll):1l,~tions9f marrow CD34+ cells. Blood, 85: 194-202, 1995. 163. ljolll1fjord, (l.R, Steen, R...Vciby, D.P., wd EgehUld" T. ,Lineage C(lrnmltment of CD34.i: ., b\lIlUlll hematopoietic progenitor'cells. Exp. Hemalol.. 21: B75-88Z, 1996. 164. Siegel. D., MCGUlMeslI, S.M., Wiski, S.L., and Ross. D. Genotype-phenotype relationshlps in studies oC a polymorphism in NAD(p)H:quinone oxidoreductase 'I. Ph.armarogenetics.9: 113-121, 1999. 45 , '--., ----------,'----------------- MOCOO044357 165. Traver, R..D. Sjege~ D. Beall, H.D., Phillips, R.M., Gibson, N.W., Franklin. W.A., and RosEl. D. Cbarw:terization of It polymorphism in NAD(p)H:quinone oxidoreductase (DTdiaphorase). Br. J. Cancer, 7J; 69-75, 1997. 166. RIlthman. N., Smith, M.T., Hayu, R.B., Traver, R.D.~ Hoener, B.A., CmnpIeman. S., Li, G.L., DOlleIneci. M.. Linel. M., Zhang, L.P., Xi, L.Q., Wacboldcr, S., Lu, W.o Meyer. K.B.. Titeoko-HoUand, N., Stewart, J.T... YlI1, S.N., and Roo., D. Ben:z=ne poisoning, a risk factor for bematological IlllIligrumcy. is lL'lSoc:iated with the NQOJ 609C_>T mutation and rapid D:acliooal excretioD of cblorzoXll2Dne. Cnnc:er Res", 57: 2839-2842, 1997. 167. Larsen, R..A.. Wang, Y:X., BanCljee, M., Wicmels, J., Hartford. C., Le Beau, M.M., and Smith, M.T. Prevalence of the inactivating 609C->Tpolymorphisrn in the NAD(p)H:quinone oxidoreductase (NQDI) gene in patients with primary and therapy-related myeloid leukemia. Blood, 94: 803-807, 1999. 16B. Marin, A. Lopez de Cetain, A., Hamilton, E.. Lewis. A.D., Martinez...Penuela, 1.M., Ideate, M.A.. and Bello, 1. DT-diaphorase and cytochrome B5 reducfJISC in human lung and breast f:umOIlI4. Br. J. Cancer, 76: 923-929, 1997. 169. Kelsey, K.T., Ross, D., Traver, R.D., Christiani, D.C" :luo, Z.-P., Spitz. M.R., Wl!Ilg, M., Xu.. x:., Lee, B.-K.. Schwartz. B.S., and Wieneke. 1.K. Ethnic: variation in the prevalence of a common NA.D(P)H quixlone oxidoreductAse polymorphism and its implications fur anti-cancer chemotherapy; Br. I. Cancer, 76: 852854, 1991. 170. Sc~nberg, D.G.. Stillmaa. W:g., Gnmlmcir,1J.,Helm, K.M., Irons, R..D. and Ross, D. Peroxidase activity in murine IIIld hUQ1llll hematopoietic progeoitor celk. Potential relevance to benzene-induced toxicity. Mol. Pharmacol., 46; 346-351, 1994. 171. Emrtmonrl, D.A., Smith, M T., and Irons, R.D. An interaction of benzene metabolites reproduces the myelotoxlcUy observed with benzene eXposure. Toxicol Appl. Pharmaeol., 91: 85-95,1987. 172. Ross, D., Sicgt:~ D., Scbattenberg, D.O., Sun, X.M.M.; and Moran, J.L. CeU-specific activation and detox.lfication of benzene metabolites in mouse !1lld human bone marrow: Identification oftmgct cells and a potential role for modulation of apoptosis in ben:z=nc toxicity. Environ. Heal1h Perspecl,lQ.f Suppl. 6; 1I71-1l!1:2, 1996. 173. Res; D. Metabolic basis of b~ne tox,icity. Eur. 1. HaematoL. 57 S;upp!...6Q: J II-l,n. 1996. . 174. Landon, SJ., Lehman, T.A., and Taylor, l.A. Myeloperolddase generic polymorphisqI and lung cancer risk. Cancer Res., 57: 5001-5003,1997. 46 MOC00044358 ;, 175. Stlllman,W.S., Vare\la-Garcia, M., !Uld Irons, R.D. The bCI!2eoCo' metabolites hydroquinone and catechol act in synergy to induce: dose-dependent hypoploidy and.5q31in a human cell line. Leuk. Lymphoma.. 3j: 269-281,1999. 176. Stillman. W.S., Varella-Garcia, M., Gruntmeir, 1J., andIrons, R.D. The benzeDe metabolite, bydtoquinone, induces dose-dependent iIypopIOidy in a buman cell line. Leukemia, 11; 15401545, 1997. 177. Stillm.an, W.S., VBR:Il11.-Gan:ia, M., and Irons, R.D. The benzenCo'metabolite, hydroquinoDc, selectively indllCCS 5q31- and -7 in human CD34+CDI9- bone marrow cells. Exp. HemawL, 1999.(in press) 178. Ohshima.,K.. Suzumiya, J, Sato, K.. et at B cell lymphoma: 708 cases in Japan: incident rates and clinical prognosis according to the REAL classification. Cance:r Lett. 135: 73-81, 1999. 179. Inoue, O. et. al Ql.Wltitative relation of urinary phenoles to brcathzone benzene CODCc:nJ:ratiollS: a factory smvey. Br. J. Ind. Med.43; 692-697. 1986. UO. Coll.ins, }J.t Conner, P. et aI. A study of the hematologic !:fI'ects of chronic low level exposun: to botJ:Lt::ue. J. Occup. Mcd. JJ; SupplS. 619-625,1991. 47 MOC00044359