Document 06x59903xZMbYqkDknR29oLmn

The Society of the Plastics Industry, Inc. 355 Lexington Avenue New York, New York 10017 (212) 573 9400 March 6, 1978 TO: THE PVC SAFETY GROUP RE: The Nominating Committee Report Gentlemen: In accordance with the bylaws of the PVC Safety Group, Chairman Nuechterlein appointed a nominating committee consisting of Messrs. Adams, Savage and Laundrie. This committee reported to the PVC Safety Group's Steering Committee at their meeting on February 28, as follows: (1) Nominated to serve on the Steering Committee for a period of three years - D. C. Nuechterlein - Dow Chemical Co. S. W. Schaefer - Diamond Shamrock Chemical Co. T. C. Walker - Firestone Plastics Co. (2) Nominated to serve as chairman and vice chairman for a term of one year D. C. Nuechterlein - Chairman S. W. Schaefer - Vice Chairman (3) Nominated to serve as Treasurer for one year T. C. Walker In presenting these nominations to the Steering Committee, the Nominating Committee noted that three openings would occur on the Steering Committee as of May 31, 1979 at which time mebers of the PVC Safety Group not presently serving would be eligible for nominations to the Steering Committee. In accordance with the bylaws these nominations are sent to all members of the PVC Safety Group for their consideration and review at least 20 days prior to a meeting where the nominations will be considered for a vote. This will be included on the agenda at the meeting of the full PVC Safety Group scheduled for Friday, March 31, 1978 in Arlington, Virginia. Very truly yours. Xt--R . V-^John R. Lawrence Technical Director SPl-08676 Abstracts of Papers for the Seventeenth Annua! Meeting of the Society of Toxicology, San Francisco, California March 12-16,1978 246. The Effect of Disulfiram on Vinyl Chloride-Induced Carcinogenesis in Mice. J. M. Winston, J. C. Bhandari, A. M. El-hawari, R. D. Short, Jr., and C. C. Lee, Pharma cology-Toxicology, Midwest Research Institute, Kansas City, Missouri. Male and female CD-I mice were exposed to 50, 250, or 1000 ppm of vinyl chloride (VC) 6 hr/day, 5 days/week for 49 weeks. To determine the effect of disulfiram (DS) on VC-induced carcinogenesis, one-half of the mice received 0.1% DS in the daily diet for the duration of the study. Bronchiolo-alveolar adenomas were found in all mice exposed to 1000 ppm of VC both with and without DS treatment. However, the tumors tended to occur at a later time in the DStreated mice. The incidence of hepatic hemangiosarcoma in the mice exposed to 1000 ppm of VC was less in the mice treated with DS than mice without DS treatment. The incidence of mammary gland tumors in females exposed to 1000 ppm of VC was also reduced with DS treatment. In mice exposed to 250 ppm of VC, the incidence of bronchiolo-alveolar adenoma was not affected by DS treatment. The incidence of hepatic hemangiosarcoma in 250-ppm VC exposed mice was reduced by DS treatment. Studies of the activity of hepatic mixed function oxidase enzymes showed DS treatment to reduce the activity. DS plus VC resulted in a partial decrease in activity. These data suggest that chronic DS treatment may produce at least partial protection against VC-induced carcinogenesis and that the effect of DS on mixed-function oxidase activity may be involved in this protective effect. (Supported by Contract No. NIEHSN01-ES-2-2084.) March 20, 1978 TO: THE PVC VOTING REPRESENTATIVES Gentlemen: Attached you will find a report on the PVC Safety Group's financial activities through the first three quarters of SPI's current fiscal year. Also included is a projection of the estimated expenditures for the quarter ending May 31, 1978. This material will be reviewed at the meeting of the PVC Safety Group in Arlington, Virginia, on Friday, March 31, 1978 and is being sent to you at this time for your information. Very truly yours. John R. Lawrence Technical Director JRL:gm Attachments SPI-08678 SPI-PVC & VCM PRODUCERS GROUP ESTIMATED SOURCE & DISPOSITION OF FUNDS ----------------tt&WWk1977-W73-------------------- SOURCE: 1. Carryover (Loss) From 1976/77 CperationsPer Ledger Print-Out Plus: Duplicate Entry of Allied Chon.Payment Less: Assessments Paid-Not Recorded on Ledger Great American Chemical Hooker Chemical Net (Loss) Carryover from 1976-1977 2. Assessments: Total Assmt. Assmt. Paid a 1976/77 Assessment No.5 $100000.00 $100000.00 b 1977/78 Assessment No.1 250000.00 246857.50 c 1977/78 Assessment No.2 585660.00 - Total Assessment Income $546857.50 Net Assessments Receivable as of 1/51/78 5. Meeting; Income: Total Funds Available for 1977-1978 ^POSITION: 1 Current Year Expenses: Legal Expense-Paid thru 1-51-78 $229275.52 -Accrued for Febr.'78 28657*94 -Accrued for 4th Quarter 85971.15 Public Relations Exp.-Paid thru 12-51-77 $105855.25 -Acer.for Jan. & Febr. '78 26458.52 -Acer.for 4th Quarter 49500.00 Meeting & Travel Exp.-Paid thru 1-51-78 $ 6850.72 -Acer.for Febr.,'78 761.19 -Acer.for 4th Quarter 2250.00 Research & Development-Paid thru 1-51-78 $ 55018.67 -Acer.for Febr.,'78 -Acer.for 4th Quarter Office Supplies-Paid thru 1-51-78 5668.65 12000.00 $"--866.S7 -Acer.for Febr.,'78 108.56 -Acer.for 4th Quarter 550.00 Messenger & Postage-Paid thru 1-51-78$"-- -Acer.for Febr.,'78 5*70 -Acer.for 4th Quarter 100.00 AMOUNT $(28784.58) ( 2460.00) 912.00 167.50 $(50165.08) Net Assmt. Due $ 5162.50 585660.00 :____________ 546857-50 $588822.50 588822.50 580.00 $705374732 $545884.61 181791-57 9861.91 48687.50 1525.25 155.50 SPI-08679 -2- AMOUNT Telephone Expense-Paid thru -1-31/78 $ 1773.41 -Acer.for Pebr., '78 197.04 -Acer.for 4th Quarter 600.00 $ 2570.45 Total Expense for 1977-1978 Estimated Net Funds Available at 5-31-78 $588254.37 $11/620.55 SPI-08680 18980-ldS u n) o) co h r*-, l rH C-- Ctf O Os CO I ' H bi oo o saO rt a >4 aJ co r-, l Os rH <D -e CJ O r- H CoOo C^ sO pH O r-- SCOO 'O Os CO & a o CQlCO Sj= efe. i Qj3 c]:*: as;a- p > op!. o <> En p- cn x: U o CO 3 O oo t>4 sO CM C-- 3 01 a) co -p c-oP -1 H O' Os pH CA sE? p ctf CO CO p w &o O rH Q) (Xa CO o IA sO pH OCO '--/ ao CM OO CA f^ MW' 1 a S rH C O n o 0x: n <3 88 o 58 1 oo CA r- 3 I II 8 # O o la I co CM rH I xa CO CM rH 8i H in CM i 8 rH XA CM 88 o VA a CM so | H fA | O O a O CO CA O IA CA o XA CM vO rH PA OCO ^P--rlsOO a \nNAVcOOc\rWr-l S3 CM o 3 ca ca Os so CM <A CO o CM oo r-o ca ca fA OssO cm ca co o CM oo <A ca <a OssO Cs! <A CO O CM Cs- (A sO CS) H O aaa rH O CM Cs- C--- c*^ -3 CM pH -3 rA cs- CO pH CNXA VA CA ** fA c^\0 CM (A CO o CM 1 SrtCnOIA WoOlCOo W 0A*_TT HHNU\roO AOs-s0O0 MCO3 WIOfHOIfA~ pH OS OO H CM oo _=f rH o 888 O O Q OP? o ctla O N <P O mtsQ sO pH 888888 ooomng owo i-l Vf\f-Q rl CM SO -3 pH CO -or US CM 00 oo V\ to pH CM O \A 8 XA XA CM o XA O o 888 8oWoOrrnin^Oo \A C-- O pH cm sO _3' 8 \A XcsAi O V\ C- pH C CA O IA \A Os CA CM CA_3f oa** rlp|S-'JS. no Os rH CO cs- co cs- fs1 sO so OS CM Cs-sO Os pH CA CA pH so Os CAsO O -3 rl rHsC CA A- O a a a Os rH CO 00 AN CM sO 'O O Os CM c~-s5 rH pH CA CA pH CM CM CA CO r*rn -zt CM O SO Q m5 so PT tA IA co u~- O 4>S Cvl flrl vO CO C-- \ a 1A IA 0O IA C-- 8 la c^ mo \ c*- \a 3 co- so-o oHo -(aPo\ co co S' &> o co C-- f- \ o -P H CA cj <A SO \ Os ca CO oto CO a C-- eo \ so +3 eo CM cj <\ r- x rH CM 5* ^----s o (A a OO co c**-- sO CM p\ a ao fs- CM CM o 1A o CA oo 8 1 CA 3 o 1A C-- pH CM OO OO so H CM t*- Cs- Q rH O sO NC Cs-sO co <o -3 CM oo a SO so CM aaaa CM O CO vC Os CA C-- CfsO- OsO> pH Os i--I sO LA rl sO CS) r-- O CD O OO r c>o Pt -P\ cm a h sQ CM SO so OssO (A pH co pa 3 ^ 8CA CS- \pH < m a CD C Q) li I nr w ft a w XJ P a 0 sXS 1 H P *rl m o cu J (0 3 CO RR 8 8 SrH 0\C0 00 ei SI P rH A 4(0) * , >H ' A| \ 4) t" PO 4) 3 P OOQQOOOOOQOOOO CMCMddCMOCQCMCMOOcOCMCOO OdcOoJdO [>r AO CD A CD A A ACM A AO d OddO AcO D O A At- 00 AcO A ACO (\J A AO OJ AAcO Ad t- cO CM CM t- 4" t- t~ a if\ r- t~ tf* rvj CM co KN * C/5 te ) CO A m -cJ \ -P 0 v f3l > A ?r 33 d fW C X+I CO rH P SB OH <CO R lAlAO AAAQ O O A A AO AO A AO O ACM A A ACM KMfNUNCJNKN^d MO 00 O CO KNr t- AAA ON 00 d iDOMfNrd 00 CM C\J O v" - CD KMAIAO o CO O A00 A A00 CO 00 4- f A A CM An CO AAcO Ad Ad ACM V f At- V CM d v" t~ lAlAO AAAQ O O lAlAlAO lAOlAlAOO lAlAlA A A AcD A A AAAC'-CM CM O CM O CO AAAAAA CO A AcD Ad AO AA Ad v* AO AAAd O P A CM 00 AQ O At- t" A CD Ad V A A A A AcD O A 00 r- v- CM Ad A00 ACM A A V AK\t" R A KN CO s R A tAf* S P I-FV C & VCM PRODUCERS GROUPl ASSESSMENT- 'IIO T IF T O L lS IS H r O ff ElSCAlL YEAR ^ 7 7 -1 9 7 8 P CM So cAo <a3 s ON fI A A AT"|Pr is OOOOOOOOOOQOOOO CDCMCMddCMOcOCMCMCOcOCMOOQ Av O'- O CD ON CD A A A-CM AAO? 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