Document 06wp4vw8xBL69RQM414D70Bwm

ma DEPARTMENT ENVIRONMOEFNTHALEASLURTVHEILLANCE AND ASSESSMENT memo one May17,2007 May 17, 20:t7 TO: JJaammeess KKeellllyy,, MMaannaaggeerr,, EEnnvviirroonnmmeen:nttaali AAsssseessssmmeenntt aanndd SSuurrvveeiillllaannccee SSeeccttiioonn wa Sarah Jon, Supervisor, Health is Assesment Unit | CA~b Sarah Johnson, Supervisor., Health Risk Assessment Unit FROM: Nancy RiclMieatth Risk Assessment Unit | Nancy Ric~ealth Risk Assessment Unit SUBJECT: Health Based Values for Perfluorooctana sulfonate | SUBJECT: Hea~th-gased Values for Perf!uo~'ooctane Suifona~e CCAASS:: &1776633-~2233-~1 ((aacciidd)) | 2299008g1:1--5566--99 ((aammmmoonniiuumm ssaalltt)) | 70225-14-8 d ethanolamine sak) | 70225~Z4~g (die{hanolamine salt) 2795-39-3 (potassium si) ~795~39~3 (potasSium salt) 29457-72-5 (lithium salt) SSiinnccee 22000022,, ssttaaffff hhaavvee ccoommpplleetteedd sseevveerraall eevvaalluuaattiioonnss ooff ppeerrfflluuoorrooooccttaannee ssuullffoonnaattee ((PFPOSF},AOAcSchhr)roonn.iicc nnoonm-ccaamncceerr HHeeaalitthh~-BBaasseedd VVaalluuee ((HHBBVV))ooff 11 ~pgg//LL wwaass ffiirrsstt ddeerriivveedd bbyy MMiinnnneessoottaa DDeeppaarrttmmeenntt ooff HHeeaalltthh {MON in 2002 fer perforochemicals were found in drinking water in several locations in (MDH) in 2002 a~er pe~uorochem[ca:ls were found in ddnMng water in several locations in Minnesota This value was update 0.0. ug/L in 2007 when more toxicological Information was MJnnesata~ This va]lue was updated to 0,3 #BiL in 2007 when more toxicological information was avalabl. 1 2009, the valueof 03 g/L was adopted nt ule. When th US, Environmental avai~labJe, in 2009, th~ value ~f 0.3 #g/L was adopted ~nt@ rule. When the U.S, Environmental Protection Agency (EPA) began review of FOS, MDH commited to another review ofthe HBV value Protection Agency (EPA) began a review of PFOS, MDH committed to another review of the HBV v:ahte after EPA provided the results of s review. The EPA announced a Health Adisory Valueof 0.07 g/L in after EPA provided the results of ~ts review~ The EPA ann~uncecl a Health Advisory Va~ue of 0.07 #g/L 2016 and MOH then began reviewing is 2009 guidance for PFOS to determine the guidance values 20~6 and MDH then began reviewing ~ts 2009 guidance for PFOS to determine ~fthe ~uidanCe values remained sufficient protective remained suffidently protective, P2P0RF1OO6SS/is2s0hh1i!7~ghhrlleyyvbbileioowa,accMcc:uOummHuludalaettitivveeermiinin ntthehdee tssheerrauumms,,uwwinitthhcoaanhhcueunmmtaarnnathhioanalfqwfiafesootffheaabbmooo~uostitt55.4a.y4ppeyraeorapsrrs.i,aDDtueurrdiinongsgetthhmee tr S22a0nen~ddr6utt/mh2ha0act1to1ttnh7hceeernecctvourinera~ctweci,neotMnnrstDoraatHfiiioocdnnoenootcefferPPrmnRFi.OOnSSeFudiirnntth,dhdreariritnn,skkMeiinn~OgguHmwwacactotoeennrrcclmmeuunudstserttdabbttieeohnkkteewpppatrtsobbtteeehclleotowiwmngolleseavtv:geeaallsipsttphhtraaothptirccgioaho,usulelsddhdorroreestsseutuleltmtriienmntric, aesegxexaprpiuoonmsssuutrcrleeoossnncstgheh-anta~terrffaomotriromemnxuupslloaaos--uffferceeddosn.aac~nGeddirnvbb.er~neFeauahsrsettt:-~shffeeeerdd,cMon~nnaDs~niHadtnetscsroaeentxxicppoluenerdsri,ieeedtnnhccteheeasiistts apipmnrodopratoterdracttnaMintnOg,t,Ha~inngeaaqaidudndasdittittihiioo~onngnhutt,oossdpphroroofrttt-ree-tccdetteriimnrniggving against tong4:erm exposures. Given these cons~deratiens~ the standard MDH equation used for derivi~g hefefaelci-obfaPsReOdSgciodnacnecnterwataisonnsotinaddreiqaukaitneg,waantderMoOnRsedrevuemlcoopnecdenattroastciookninetic model 0 ssc the healtMbased guidance was not adequate, and MDH developed a toxicoMnetic mode! to assess the effeG of P~OS concentrations ~n drinking water on serum concentration. cTTohhmeepCCloeontntetaadmmtiihnneaannptrtssimooaffrmEyemrreegvrgiiiennwggaCCnodonncJceiemrrnnJa((CcCoEECbC)us)ppcrrooogmgrpralamemtcceoodmmtpplhleetsteeeddcottnhhdearrreeyvvirieeewwv.i.ewHH.eellAeennn tGGooeeerddeemrn~team icrreoetvvmhiiepecwwlheeewtemaaidssctahhhleeelrldpevrooiimnnewaAAurucyggourumsesptvtliee330t0w,e, da22n00id12n66JF,,im2aa0nnJd1a7ctthohbebeyufnsitnhlcaeoltCmteEepaCalmemptrerrodeegvvtriiheaeewmw,swweaaacnssodnhhtdeehalleddry1oo1rnnetvhAAipepcrwiroilml, p22Al00n,e,2ti2n0e01td1e77r.b~imyPPtFFtheOOeaSSCmi~E:ssCtthhee fi~h chemical review completed ff~ FY20$7 by the CEC program, and the ~2th completed by the CEC #p~roo~grraamm iinn tthhee 22001&66//2200~177 bbi~eennnn~iuumm., Exhibit 2477 22447777..00000011 ER-- STATE 07457240 exposures have the potential to stay inthe body for an extended period of time. Thereafosirngele PPFFOOSS bbiiooaaccccuurmeuullaatteess wwiitthhiinn tthhee bbooddyy,, ccrroosssseess tthhee p[~laacceennttaa,, aanndd ppaarrttiittiioonnss ttoo bbrreeaassttmmiliklL. SShhoorrtt--tteerrmm e~osure~ h~ve the pote~t~a~ to stay ~n the body for an e~t~nd~d period of time, Therefore a single HHBBVV hhaass bbeeeenn rreeccoommmmeenBddeedd ffoorr sshhoormt-tteerrmm,, ssuubbcchhrroonniciq, aanndd cchhrroonnikc dduurraattiioonn., SSttaaffff rreeccoommmmeenndd tthhee ffoolliolwow~inngg hnoonm-cea,rnicceerr HHeeaalltthh~-BBaasseedd VVaalluueess ((HHBBVVs)] ffoorr aal~ll dduurraattibonnss:: short-term (up to 30 days); ssuubbcchhrroonniicc ((uupp ttoo aap~pprrooxx:i~mmataetellyy 88 yyeeaar~ss));; aanndd cchhrroonniicc ((ll~iffeet~timmee)) eexppoossuurree.. casNos. ER| ---- | TThhee ffoolllolowwiinngg HHBBVVss hhaavvee bbeeeennddeeririvveedd ffoorrPPFFOOSS:: 11776633--2233-11 ((aacciidd)) 2299008811-@566-@9 ({aammmmoonniMu;m~ ssaalltt)) 70225.10.8 (ethanolamine ak) | PROS | Acute - - 70225444 (diethanolamine salt) | 2795-39-3 (potassium salt) | | ~ Z795~39-3 {petassium salt) P~OS Acute | 2047.72 (thio ah | ~ 29457q2~5 (litNum salt ................................................................................................................................................................................................................................................................................................................... Sor| erm Sho~4erm -- a [subchronic | system, immune | 2927 | Subchronic Developmer, t~l, Hepatic (Liver) system, ~mmune 0.027 I A Chto~ic ssyysstteemm,,TThhyyrrooiidd ((EE)} ... A .... NNAA =~ NNoott Applicable TTHhhueemauupnpddaHateteaedldtPPh-FFBOOaSSseggduuiiWddaaatnnecceer vGvaauliluudeeassncaaennddtatthbhleeeaaottnttaaMcchDheeHddsssuuwmembmmsaiartreyy.ddToohcceuumGmeuenitndataatnticiooenniwwmiplillll ebbmeeenaatddaddteeiddottnooTttehhaeem Human Heakh~Based Water Guidance table on MDH's website, The Guidance Implementation Team `mmeemmbbeerrss,, wwhhiicchh iinncclluuddee rreepprreesseennttaattiivveess ffrroomm MMiinnnneessoottaa DDeeppaarrttmmeenntt ooff AAggrriiccuullttuurree,, MMiinnnneessoottaa PPoolIlluuttiioonn CCaonntrtrooll AAggeen~sccyy,, MMDDHH DDrdinnkkii~ngg W Waatteerr PPrrootteeccttiioonn aanndd ootthheerr MMDDHH pprrooggrraammss wwiillll bbee iinnffoorrmmeedd about the new values in an upcoming meeting. AGovDelivery message announcing the finalized values about the new values in an upcoming meeting. A GovDelivew message announcing the finalized values willbe sent when the updated information is added to the MOH website. wil be sent when the updated information is added to the MDH webs~te. YYoouurr ssiisgnnaattuu~ree,, iinnddiiccaattiinngg tthhaatt yyoouu hhaavvee rreevviieewweedd aanndd aapppprroovveedd tthhiiss vvaalluuee,, iiss rreeqquueesstteedd.. 8 ely, Section Manager ADDatattteae:c: hm2ent : Ja Toxicological Summaryfo r PFOS Attachment: Toxicological 5ummaq for 22447777..00000022 2 STATE 457261 STATE 07457241 0 ODFEPHAERATLMTEHNT Health Risk Assessment UnHHiee,aalElttnhhviBraaossneemddenGGtuauillddHaaennaccleetfh~ooDrriWWvaitsaietoernr Heatth Risk Assessment Unit, Environmental 651-201-4858 Hea!th Div(sie,n 65~..201~4899 WWeebb PPuubbltiiccaattioiro~n DDaattee:: MMaayy 22001177 TTCAooSx:iicc17oo6l3!o-o2g3gi4i1cca(aalclidSS) uummmmaarryy ffoorr:: PPeerrfflluuoorrooooccttaannee SSuullffoornaattee CAS: i7'720693208-521-.315464.8(9a((~diadim)emtohannioulmamsianlte)salt) 229749557--3792--35((ploittahsisumiusmalsta)lt) Synonym[[NNsoo:tteeP::Fp#OeeSrf,fflluuPoderrroofoolccuttoaarnnooooaacttteeanaaennsiiouol#nfoddnooieecssacnnioodtt hhaavvee aa ssppeeccififiicc CCAASS nnuummbbeerr,.:] Synoriyms: PFOS, Perfluorooctane sulfomic ~c~d aMndDHkecyonsdtuudcytieaddentfiofciucasteidonrec-oonvtaaluianteidonw,itwhhiincthhereElPieAdhHeeaavlitlhyEufpfeocntsEPSAu'pspohratzaDrodcausmseenstsfmoernt tPhoerftlouxoircooolocgtiacnaelSluiltefroantautree w(PaFsOnSo)trceolndeuacsteieddn.May 2016 (EPA 20163). A complete evaluation of `Shortterm, Subchronic and Chronic ~Non-Cancer HealthBasedValue (HBV)= 0.027 ug." a""DrDe~ueeth~teoomtthohesethhiaiggphhpllryyopibroioiaaactccecuudmmousule|aamttivveeetnnaatatuunrrdeeotofhfePPsEFtOaOnS8daaarnndddehhquuumamiaaonnnhhoaalfdqleirffeivooeff tnnheeeaarHrllyyBY5.44wayyeseaarnrsos,l asspeeprrruucmmprcciootnenc.ceenSrtthir:oraartttiioonnss Sfa~,eereerrammntheeerxxeppmcoooosssmuutrmreaeespsnpdhhreaaovdvpeerfiaotthrtheeeshdpuoooorlsteeeenntmrtiamaell,trttiosocussab~tncaadhyyotnrhr~iettchh,seetaabbnnooddddayyirdoffoonerrqiaaucn~a:deetiuxxorttaaeetntniododneedsdde.dppTveeehrrieiotohd2de0oo1Hff7BtmimVeH.eBwVaTTswhheanersoreetfdfaooeprrrepeivraaoepdssriiuinnasggtiellene,gSHHahBBoVVrt~hhaass. tp{3oorexxeeiccsnaoekknriietrn~ecedoeltmiibcceml((oTeTwnKK.)d) emmdoodfdoeerllsddheeovvrete-l,ttooepprmee~d, by MDH with inputfrom anextemal peer review panel. subchronie and chro#ic duration& The 2017 HBV was by MDH wi~h i~put from ah external peer review panel, Mode! details derived using Mo~e/detai~s aaarree. 3res~nted below, nR**aeRtlieaoltnaaitlivvgeeeSSneooruuarrlcceepoCCpouonlnlatrtrbiibuoufntisiooonn ((rRReSSpCrC)e:)s:ebbnatassreeoddn-oownnatcceuurrrrreeexnnpttobbsiuioormmeoson,nitiatoonrriinRngSg Csseeorrfuum0m5ccoo(nn5cc0ee%nn)ttrrwaaattiisoonnssselrferoocmtmedlleofccoaar~lwaaanntdder ingestion. ~ational genera~ ngestion. ~populal:iens to represent nomwater exposures, an RSC of 0.5 (50%) was selected for water oIt~rn)ttueapkkepeeRRreatpteee:r:cIinennkkteeieoeppbiirnneggaswwtiimtthihlMMk DiDnHtHa'skepprrfaaaccttetiisccee(,.Ta99b55l"~e pp1e5e-rm1c,eennUttilSleeEwwPaaAttee2rr01iin1it)aakkweeerrraaetteeussse(~dTT.aabSblrieeea33s--1t1riaalnnkddc33o--n33c,.enUUtSSrEaEtPPiAAon22s00w11e1tr))e ococaerrl!euccatpu~slp!taae-ttreeedddpbeibyrnycaemmnuntlutitellteiixppplblyoyriiesnnuaggrsetttmhhseeictkemmnaiaanlrttieoaormk,neaalalrasspteeeerrrsuium(omTdoaccfboonlneeccxe1cen5lnl~urtsr1aai.ttviiUeooSnnbErbbePyayaAsat2lPP0eFF1eQdO1i)SSnwgbberfrraoeeraas.ousintsmmeeiuillykk,eraB~arrranewnsasaisfesetrmruiffsiaakecctdctoo~rarnscrr~ferf ne11pt..r3r3ae%%t.sio,ennFFtsooarrtwittehvhreeee obfreaarset-afesdonianbfal,e~meaxxpiomsuurme esxcpeonsaurrioe, sacpeneariroido of exclusive breastfeedin9 for one yank was used as representative of a reasonable maximum epos[|re scer~a~r~o, sAAigssniimimfppcllaeenteeqqduiuagat.tiiooHnnowiissevttyyeppriic,caatllllyhy uutssoeexiddcottckoicncaealtlicccuullmaaottedeaHHlBEuVVssedaatt1tthhdeeerppiaarvrtet ppteherer bHbiiElliooVnnfollerevvPeelFl wOwiSit~hsrrheeossuwulslttdss rrtoohuaurtn~dsde8eddruttomo oon~ee. 2ccsoo0i#ne1nc7ceifeniHcntatrrYnaatttiidocoiongnn~sitt.awwiHeenorrseweteiiwmvmoepprdaa.icgcttihtteeesdd.tobb.yyxiccchhoaakninnggeeeti~sc in water concentrataitothnes part per tion level. As mallei used to derive the HBV for PFOS shewed that in water ear, castrations at the pat1 ~er trillion level. As a rosut, serum a result, tthhee 20t 7 HBV cRoen~fae~rne.sntcweoD.#olgsiets/.Concentration: HED/Total UF = 0.00051/100 = 0.000051 mgfkg= Re[Ference DoselCancentratiol~: c(H(CoCEnrr:cDI.e:fCCnTDtDor((taaSStDlDi)Uo)IInFGGiSS=s 6VV0..AA02FF060/RR51a0a1t0ts1s)1)=.~000~{.T=h0h6ee03.cc0moo0gmr0/rLa0e.s0sp5pNo1oonntdmed:iignnttggkhgiss-see~srrueumrmum concenlration concentradon concentration isis is inappropriate to usefor 6.26/100 = 0.063 mg/L. inao#ropriate to use for individual Note: this individual serum Source of toxicity value: Daaesstsseeerssmssmimneeendnt,tb*.y**".1MDH in 2017 Source ol= toxicity vague: Determined by MDH in 20t7 PPFFOOSS-- PPaaggee 11 ooff t111 22447777..00000033 STATE 07457202 STATE 07457242 motor activi and decreased habluson, decreased eves | PPooiinntt ooff DDeeppaarrttuurree ((PPOODD)):: 6a6.v.22e66rammggge//sLLessreeurrmuummcoccnoocnencncetenrntatrtraaitto.iinoonnfor((EEFPP2AAge22n00e11ra6Gtaaioppnrr.eeddNiiccOtteAeddEL Dose Adjustment Factor (DAF): f0farr.ovo0emm0r0aLL0guu8ee1et;sbkekTereourrxmieecrtrocaakolli~n22oe00et00ni55tcrbbaA))tdiojru~s[tomreFn2t generatiot~ NOAEL based on Chernical- Dose .Adjustment Fa~or (DAF): Specific Clearance Rate = Volume of Distribution (Lig) x 0.000081: Toxicokinetic Adjustment based on Chemical~ Specific C~earance Rate = Volume of Distribution (L/kg) (0(LL.tn0~20?lJ0HH0a8alf1ffqfiL~eie,k,gdc-aadyyas~y))(==US00..E2233PALLiik2gg01xx68((0)0..669933//i1987711 ddaayyss,~) = HHuummaann EEqquuiivvaalleenntt DDoossee ((MMDDHH,. 22001t77))1: POD x DAF =6.26 0..000081 L/kg~day ROD x DAF = 6.26 mg/Lx 0.000081 (US EPA 2016a) mg/L. 0.000081 LLi/kkggilddaayy =0.00051 Total uncertainty factor (UF): mm1g0g0klkgg---ddaayy Uncertainty factor allocation: Total uncertainty factor (UF): Uncertainty factor a~tocation: i331n0fflo0orrrasiirpn~ettceeirresssppeevccaiireeissadbdiiifftffeyeraerennndccee3sso((frfoorrdattootxxaiibccaoosddevynnuaanmmciecircsts)a),i,nt1y0 for wa(i(naarhddt-ddaaiinsttiptooeenncadail)el ss~ttvuuaddriiieeassbirrleietgygaaarrdncidinng3gl immunotoxicty are for database uncertainty immunotoxicity are || Co-CCcririittlicccaaallt eeeffffffeeeccct(t((sss)):):: wDIDneaecorcrfrrafeesnaaptssreieedndd)g ppeuuxpppobbsooedddyydwwuereiiiggnhhgttdevelopment: delayed eye || Co-critical effect(s): `doinoeppveoeennffilisnnopggpr,,imniiegnnncce,rrexedpaaeosscesereddedssatdtseueernrdaianlglglddudeecfefoeevsccetetlssot,,polmccehheraaannnntcgg:eeed,sseiliia[n~nyclleruudennaggesyeed | development, decrea,~ed glucose tolerance, omoifnfottahhtdoyyurrrlootaxxcaiitnninvieeimtya((TlTa4s4)n:},diaavdrneeiddrcwrddeeeeaiccgsrrheeetdaascsheehaddabnisstguuurearvsvitiivovaaanlc.l,c. odmepcarenaiseeddblyevels clcIre~hhvaaaennldsgg~eeotssfatiinahniymccrhhaoooxlslile:ensseltitvee(erTror4ol)wl,lleeedivvgeeechllrstsecaaahnrsaiddendghhieiSsssttRooatBlocogCgcyyo~r;meddspeepacocnrnreiseeaead.sseebddy iwliennevccierrgelehsaatsosaeefnddthdNNycrKKoelxcclieneuliea[llr,aia(ct'ctTyti4ivv)i;it[yy~,,eddceereccarreesaeassdeeSddRssBppiCleeeernensaapnnoddnstthehy.ymmuuss AAddddiitiiviitt~y" eennddppooiinntt(ss)):: wDTDheeeyvivregeolhliootdppammned)netncatealll,l,ulHHaerepitpayattiicc ((LLiivveerr)) ssyysstteemm,, Iimmmmuunnee ssyysstteemm,, *=b~a*t,SeSederrouunmmoccioonanccteenontrtraattiiaootnneissduupsaserfuauml effotorrerifnsofoarrnmidninsgghpop~uub~d0iichthh~eeohaaetlythheropposicdl!iiccoyyraaHnnddCninHetrerpSpreraSeitainnSggspe~onotpsufltatofio.noObbaossreed ne~x;xp~oosssueurrser.& oTTuhhtiissvale fs individuals. based ~n populat~omba~ed parameters and ~hou~d not be u~ed ~r clin~ca~ assessment O~ for ~nterDret~ng serum levels JX) TTooxxiiccookkiinneetticc MMooddeell DDeessccridg.ptitioenn:: SS"Teehrirusumemquccaootnnicceoennntwtrraaatstiioounnsssedccaabnny bbEeePAcc,aallcctuoullCaaattleecddulffrarotomemttthhheeeHddooEssDee aafnnrdodmcctlleheaearrPaanOnccDee srraaettreeuuumssicinnoggncttehhneetrffaootlllilooownwsiin.ngg eeqquuaattiioonn, This equation was used by EPA, to calculate the HEDs from the POD serum concentrat;ons, erum Concentration (72) = E7 Clearance Rate (7gaea) WWhte~reer.e: `Doss Do~'e (mg/kg-day) ~m#.~g~dax~ = = Wal Wa~e~ or or 8Br,re~aasst~mmilflkk IInnt~akkee ((lL.i_k~g~-dda~y)} ~ x L~. eevvae!l ~infl WWaalteerr oorr B~rteaaasst#mt~ilit~k ((ram!L!L)3 an CCl[eeaarraannccee ((t~L#i~gd)) <= 'VVo;3l~uumm=oeooff ddibs~tri~bbuuttiioonn ((~Lkigg)) xx ((LLnn h2~aaltit4tifee ((ddaayyss))) wTTawwtooereexxsptpaootssiuunrrgeeasstccbeeinntaahrriiaoonssdwwceeorrneetieenxxuaaimnmignineIedndg:e:sI1t))ioaannnoiifnncffaaonnntttffaeemddinwwaiittthhedffoowrrammtuuellraatrrheerccooounngsshttiiIttufuett:eedadnwwdiitt2hh)ccaoonnntitaanfmmaiinnntaatteedd wesexiacmctlue~ulrus'asistivvteeaedlriyytiinnbbgdrriaev:aaaitsdsbutt4aifrleteshddbaffeonogrdra11cn22oInmmftoeionnwnutithihntshsg,a, iffnoopgllrleoels-woetwiexeoiddnstbboiyyfngcddrorbiirno~ntdkkaiyimnnggbinuccareotdrne~etdtnaawmmtihairnr~taeoaturteegthddhrwwopaluatagetcerher.n:ltifItaren~l; bbraooanttndhhsf2sse)ccreeannonafarirPniiofoFassOntttShhee. simulated ir~dMduafs began life with a pre~exi~tia~ body burder~ through place~ta~ ~ransfer of PFS PFOS- Pag2e0f 11 PFOS * Page 2 of 1 t 22447777..00000044 STSTAATTEE 0077445577224433 A A A AR ((mmaatteerrnnaall sseerruumm ccoonncceennttrraattiioonn xx 4466%%)) bbaasseedd oonn aavveerraaggee ccoorrdd ttoo mmaatteerrnnaall sseerruumm ccoonncceennttrraattiioonn rraattiiooss. reported in the literature The serum concentration of the mother at delivery was assumed t,o be at `ssteteaaddyy--ssttaatteeo. CConosnissistteennttwwiitthh MMDDHH mmeetthr~ooddooltooggyy,, 9955I~ ppeerrcceennttiillee wwaatteerr iinnttaakkee aanndd uuppppeerr ppeerrcceenntitillee bbrreeaassttmmiillkk iinnttaakkee AI A rates were used to simulate a reasor~abfe maximum exposed individual. A P~OS breas~m~lk transter TT a rr AE fel re factor of 1,3%, ba~ed on average breastmilk to maternal serum concentratiot~ ratios repo~ted in ~he SR Iiterature, was used to calculate breastmilk concentration. Accosting ~o the 2016 Breastfeedincj Report LS LT Card (CDC, 2016), nearly 66 percent of mothers in Minnesota topoi1 breastfeeding at six months, with SE a pr foal hn 31,4 percent exclusively breastfeedin9, The percent breastfeeding dropped to 41% at twelve months. Br eR ~DH selected aa exclusi've breastfeeding duration of one year for the breast4ed infant scenario, SO -- Daily post-elimination serum concenttaLion was calculated as someone(19) p- PR py sme. | va i) x Bw kod !| TToo mmaaiinnttaaiinn mmaassss bbaallaannc~e,, ddaaiiliyy mmaatteerrnnaall ssee['rL!u[~m] ccoonncceennttrraattiioo~nss aanridd lloossss--ooff--cchheemmiiccaall vviiaa ttrraannssffeerr ttoo tthhee iinnffaanntt aass wweelt~l aass eexxccrreettiioonn rreepprreesseenntteedd bbyy tthhee cctleeaa:rraannccee rraattee,. wweerree ccaallccuullaatteedd., [ ecopwme `SSuummmmaarryy ooff MMooddeell PPaarraammeetteerrss Model Parameter [~ aHraa~ft4eife VVoolluummee ooff ddiisstttriibbuuttieonn ((VVdd)) VVdd AAggee AAddjjuussttmmeenntt FFaaccttoorr CClleeaarraannccee RRaattee ((CCRR)) PPllaacceen~ttaalt ttrraannssffeerr ffaaccttoorr (%of maternal serum level) BBrreeaassttmmiliikk ttrraannssffeerr ffaaccttoorr (%of maternal serum level) WWaatteerr I~nnttaakkee RRaattee ((LLinkggu-adl)) Seen B~easb~ilk intake Ra[e (L~kg-d) -- Body weight (kg) | Vou Value Used 1199771i ddaayyss ((UUSS EEPPAA 220011660c)) 00..2233 iU.Jkkgg ((bUSS E~PPAA 2001!6cc)) 22.,1I aaggee 11--3300 ddaayyss ddeeccrreeaassiinngg ttoo 1! ..22 aaggee 55--1100 yyeeaarr~s aanndd 11..00 aafftteerr aaggee t100 yyeeaartss ((FFrriiisi-sH-aHann~seenn 11996611:)) 00..000000008811 LUikkgg:--dd,, ccaallccuullaatteedd ffrroomm VVld xx ((LLnn 22a!hiati-fqififee)) 4466%% ((MMDDHH 22001I770b)) 11,.o~3>~%~ ((MMDDHH 22001177bb)) 9955~ ppeertcceenntti}llee ccoonnssuummeerrss oonnllyy ((ddeeffaauulltt vvaal~uueess.~ MMDDHN 22000088)) Tete ((TTaabbllee 33~-11 && 33--33, UUSSEEPPAA 22001i1l)) Upper percentile exclusively breast4~! ~far~ts (Table i 5~!, US S------ Calcula~:ed from ware[ ~ntake and breastmiik iatake rate tables PFOS ~ Page 3 of 1 ! 22447777.,00000055 STATE 07457244 AA rreellaattiivvee ssoouurrccee ccoonnttrriibbuuttiioonn ffaaccttoorr (I RRS$CC)) iiss iinnccoorrppoorraatteedd iinnttoo tthhee ddeerriivvaattiioonn ooff aa hheeaal~tthh~-bbaasseedd wwaatteerr ams Fon et es De Pa guidance va~ue to account for non-water exposures. MDH utilizes the Exposure Decision Tree process Se EP Ss dos pps Ce Wot oat opera pe presented ~n US EPA 2000 to derive appropriate RSCs, MDH re~ied upon the percentage method to er a tdleet relative potions of wa~er and non,water rou~es of exposure The ~81ues d the du~.tion specific re me default RSCs (0,5, 0,2 and 0.2 for shoR4erm, subchronic, and chronic, tespeotively) are based on the a ee magr}itude of contnbution of these other exposures that occur dudng the relevant exposure duration ae ar Eo fk (MDH 2008), However. in the case of PFQS application d ar~ RaG needs to account for the long oe tot tf e~im;nation hal#life, such that a person's serum concentration al any give~ age is not only the resu}t d SA ut ar his or her current or recent exposure~ within the duration of concern, but also from exposu[~ from years oepast. S`Seerruumm ccoonncceennttrraattiioonnss aarree tthhee bbeesstt mmeeaassuurree ooff ccuummu~lalattiivvee eexxppoossuurree aannud ccaann bbee uusseedd iinn pol!aacceeooff tthhee gre RfD in the Decision Tree p[ocess, Biomonitorin9 results from new residents who= were not historically Ds exposed to contaminated water in the East Metro can be used to represent nomwater exposure8 ((NNeellsoonn,, 22001166)).. The seerruumm ccoonncceennttrraattiioonnss iinn tthheessee rreessiiddeennttss wweerree ssiimmiillaarr iipn mmaaggnniittuuddee ttoo tthhoossee ffoorrtthhee a | general public reported in the most recent National Report on Human Exposure to Environmental rr er | Chemical~ (CDC 2017) MDH selected an RSC of 50% [or exposure from water ingestion based or}: + Ahigh-end, conservative estimateof background, non-water exposures represented by the 95 | A high,,-end, conservative estimate of background, nomwater exposures represented by me 95~ ty percentile serum concentration for new East Metro residents (0,02i mg/L serum.u and BL AeTre A is AA ASA | The USEPA Decision Tree RSC ceil:ing of 80% to ensure a margin of safety to account for possible unknown sources of exposure ATE EH ar TE PT TE As mentioned above, two exposure soenanos were examined: 1) an nfant fed formula reconstituted wwiitthh ccoonnt[aammiinnaatteedd wwaatteerr ssttaarrtiningg aatt bbiirrtthh aanndd ccoonnttii~nuuiinngg imnggeessttiioorn} o.off ccoonnttaammii~naatteedd wwaatteerr tthhrroouugghh lliiffee:; and 2) an infant exclusively breast-fed for 12 months, followed by drinking contaminated water through and 2} an infant exclusively breast4ed ff;r 12 months, fo!iowed by drinking contaminated water throL~gh lliiffee., a ---- For the firs~ scenario;, the formuta~fed infant, the: water concentration that maintains a serum en am a erBaae.n concentration attributable to drinking water below an RSC of 50% throughout life is 0,060 LE Because of the long ha:!fqi~e; the serum concentration curve is very flat and even a smalt increment iinncc[reeaassee iinn tthhee wwaatteerr ccoonncceennttrraatflioornt ((00.;00861I #ugg/iLL)) rraaiisseess tthhee sseerruumm ccoonncceennttrraattiioonn aabboovvee tthhee 5500 }p~earrcceenntt threshoid for nearly 9 years. fom Te He ; Agetears) [E---- PFOS - Page 4 of 11 22447777..00000066 erare nirass STATE 07457245 AAapnpppeilyxyicinneggedtthhaiinsscwweaoatfteerrthcceoonn5cce0en%nttrrRaatStiiCoonntohefrfe00s..h00o6l6d00,uHbggu//tLLoiifnttthhheeeeccnootnnrtteeexxrtteofoeffraae: nbbcrreeeaasssettr-ffueemdd ciinonffnaacnnsttnrrueersasutt!oteenddfoiinnr mnnooottrooennllyy ta{ihnhnafananenxotoc,nneeetehdyyeaeeanwaracr..teeiInonrfooctorhrdnedceere5ntt0roto%rmamatRaiiSniontnCtaasiithnhnoi'auaeisssdheeonrruloudtmmebccxuooctnnecoceefedntnht0trer.aa0teti2inoo7tnnirgeaaLtto~.oerrfbebreeelnloocwwe an RSC of 50% fo breastfed serum conce~tration for more an RSC of 50% for breast~fed ir~1ants, the water coneentratior~ should not exceed 0.027 Hg/L. rnsfo Scena (pe cl 5 PS err Concentrations st Wate Connon D027 Fo fi oe ~~ om ~~ Je iDDnuufeaentttooeccxhhprrooonnsiiccebbsoiocaaaccnccauuimmouuasttatitihooennmiionnsttthheemimmolotnthhgeerSrcaaennnddarssi~uo.b~nsbssteqequrueemnnstot ttrraawnnasstffeeerrr cotoonbbcrreeenaatsrstatmmtiiliotkkn,sl .tthheTeobbrereenaasssut#rffeeedd protection of al infant exposure protect:ion of all segmentsof tha poguiation, sce~ario is the most limiting segments of the pof3u!atio~, the final scenario the final healthbased value for PROS is et a 0.027 i~n terms of water concentrations. To ensL~re health~based value for PFOS is set: at: 0,02:7 poll. Ceaanrc,ceortHHea~ll~thh BBaasseeddVVaal~uuee ((ccHHBBVV)} ==NNoottApplicable CCaanncceerr ccllaassssiiffiiccaattiioonn:: "Tumor site(s) `SS!looppee ffaaccttoorr ((8SFF)):: SSoouurrccee ooff ccaanncceerr- ssllooppee ffaaccttoorr ((SSF~)):: T~.~nor site(:s):, SSuuggggeessttiivvee EEvviiddeenncceeooffCCaarcrciinnooggeenniicc PPoot~eentr~iatila/((EEPPAA 2N2o00t1t66Abbp))plicable Not Applicable NNoott AApppplliiccaabbllee Liver and thyroid tumors were identified in both contol ard Liver and thyroid t,.~mors were identified in both contro~ exposed anima at levels that dd not show a direct :exposed animals at levels that d;d not show a direct relationship to cose. relationship to dose, Volatile: No Summary of Guidance Value History: SL~mn~ary of Gaidance Value History: A chronic nHBV of 1 gi was frst derived in 2002. A revised chronic nHBV of 0.3 yqiL was derived in A chronic nHBV d I pg/L was first derived in 2002~ A revised chronic nHBV of 0,3 Ijg/L was derived in 2007 an promuigaled as an nHRL in 2008. In 2016, EPA released a Health Advisory of 0.07 poi. for 2007 and promulgated as an nHRL in 2009. tn 2016, EPA released a Health Advisory or 0.07 #9tL for PPFFOOSS,, MMDDHH ccoonndduucctteedd aa rFee--eev~aalluuaattiioonn aanndd ddeerriivveedd aa rreevviisseedd nnHHBBVV ((aapppplliiccaabbl!ee ttoo aallll dduurraattiioonnss)) ooff 0.027 gL in 2017. Tha 2017 nHBY i lower than he previous valueas th result of: 1 incorporating 0.027 tJg/L in 2017. The 2017 nHBV is lower than the previous value as the result off 1) ir...corporating tthhee mmoosstt rreecceenntt ttooxiiccoollooggiiccaall iinnffoorrmmaattiioonn aanndd 22)) cchheemmicioala-Fssppeceicfifiicc eexxppoossuurree ccoonncceerrnnss ffrroomm bbrreeaassttmmililkk.~ PROS -Page of 11 PFOS ~ Page 5 of 1 ! 22447777..00000077 STATE OrisTase, STATE 07457246 -_-- ey || `Summaryoftoxicitytestingforhealth effectsidentifiedintheHealth StandardsStatue (144.0751): | i Tem [rm[ove [oe mmm] | FEE,rv~oe,mennsiitffuttdeei~settisinngcgoffnoodrauractsspepedeccififo~iroccthhheeeaarllttphhureefpfffoeesccettsww.aaMssDnnoHott hccaoosnnddcuuoccnttseeidddeffborrredttNhtisshecchhfeoemlmilcoicawali~n,g iiinnnfffooorrmrmmaaatttiiiooonnnaaibbnooduuettvet~lhhaoatptieenffgffecchtteai~lgitghhhtptrbebteeacaetvvavaiel!.laabbl!e: | | from ~udies conducted for etlhe~ p~rI:.,oses. M.DH has considered the following info[mation i~ developing heai~h protective uidanc,e Bndocdne ImmunotoxicRy Devei!opment Reproductive Neurotoxicity Tested for ssppeeccififiicc esfffieecntt?? Yes Yes Yes Yes Yes rmEffects observed? Commen~ on extent ~ test~r~g er eff~ec~: Yes2 Ye s" Yes~ Yess [Note." MDH conducted a ~:-u~ed re~evahJatiot~ which re,~@~ upon ~PA~ hazard a~es.~met# a~d key study Mez?fi#caf~on (EPA 2016a). A complete evaluatzon of the toxicological i~teratut~ was t)o~ conducted.] * NNuummeerroouuss hhuummaann eepoiiddeemmioioltooggiiccaall ssttuuddiieess hhaavvee eevvaalluuaatteedd tthhyyrrooiidd hhoorrmmoonnee lleevveellss aanndd/oorr tthhyyrrooiidd digease in association with serum PFOS. Results from these studies have provided Jimited suppo~l for an association. Stronger associations were found in populations at risk for iodine deficiency or positive aannttii-T-TPPOO aannttiibbooddiieess ((aa mmaarrkkeerr ffoorr aauuttooimimmmuunnee tthhyyrrooiidd ddiisseeaassee)).. S`Sttuuddiieess iinn llaabboorraattoorryy aanniimmaallss hhaavvee rreeppoorrtteedd ddeeccrreeaasseedd sseerruumm ttrh~yyrrooiidd lleevveellss,, in ppaarrttiiccuullaarr,, tthhyyrooxiinn (T4) in offspring and adult animals at exposure levels similar in magniiude to the critical effect. Decreased T4 has been identified as :a coocritica! effect and Thy reid has beeo identified as an Additivily En@o~nL :2~ AA ffeeww hhuummaann eeppiiddeemmiiooliooggyy ssttuuddiieess hhaa~vee eevvaalluuaatteedd aassssoocciiaattiioonnss bbeettwweeeenn i~mmmmunuonsouspupprperessssiioonn measures and serum PROS, However, no clear a~sociations were reported between serum PROS and rates of infectious disease, Studies m laboratory animals have shown that RFOS exposure alters several immunologic measures (eeeffff,egec,ct,@tssouocpccpcuruerrasasttioeenxxppooofssSuuRrreeBClleevvreeellssspsosiinmmsiiellaa,rrattnoodtt!hhoeer iPPnOOcDrDe.,asAAessdaanrraeetsusuculalttlt~khhieleleiirmmcmmeululnnaeectssivyyistsytte)e.mmSohhmaa8sebboeefeethnneiisdd.eeennttiiffiieedd aass aann AAdddidtiitivviittyy FEn~dnpdopionintt aanndd aa ddaattaabbaassee uunncceerrttaaiinnttyy ffaaccttoorr" hhaass bbeeeenn imnccoorrspoorraatteedd riontteo ~tnhee ddeerriivvaattiioonn ooff the RfD. *~ HHuummaann eeppiiddeemmiioollooggyy ssttuuddiieess hhaavvee ssuuggggeesstteedd aann aassssoocciiaattiioonn bbeettwweeeenn p~rreennaattaall PPFFOOSS sseerruumm lleevveellss and lower birth weight, however, this association has not been consistent. Studies conducted in laboratory animals have identified several sensitive developmental effects. Decreased pup body weight appears to be among the most sensitive effects and, in par[, forms the basis of the Reference Dose and corresponding serum concentration of concern. A timit[ed number of studies have also reported changes in male reproductive development and changes in energy metabolism (e.g., glucose levels lipid metabolism,~ following exposure dunng developmenL Additional effects, including increased pup death were observed at higher exposure l~vels. "4 AA s~mmaalll nnuummbbeerr ooff hhuummaann eeppiiddeemmiiooliooggyy ssttuuddiieess hhaavvee rree#poorrtteedd aann aassssoocciiaattiioonn bbeettwweeeenn pprreeccoonncceeppttiioonn serum PFOS and gestationa~ diabetes and pregnancydnduced hypertension. There has also been some evidence of associations between serum PFOS and decreased fe~tility~ however concerns have been raised over the possibility that this is due to ~everse causation~ PFOS -- Page 6 of 11 22447777..00000088 STATE 07457247 SrSettpuurddoiiedeussctiinnivllaeabbooorrrgaaattonorrsyywaaeningiimhmtaasl,lss dcdeoocnnrooettasii~enqdddiicecaapttieeditthdhayatmaffeelrrttsiilpiitteyyriimss aacossueerntns,siitatiinvvede eeennvdidpdpoeoinninctte,, owwfiittdhhisddreeuccprtreieoaanssoeefssthiinnemmaal!ee arbbebl!oopovorooedd)d--~.ueescstTtitehveesesr--ebobfaraogrrrradeene,rsrtoowhcceecciuuRgtIrhriDtinsn,vggodaauettlcdeerxxebppaeoosssepuudrrro:eteeeplcleietdvviieedvlelysosmfhhaiitglghhhseeepsrreerttmhehafafnnceoctttuhshr.o~otss,eeaccnaaduuessivinnidggeddneecveveeloloof ppdmmiserneutnpa~tlilo(ntooxoxifcitithcye((sseeee above). Therefore~ the RfD would be protective of these effects, #`~aDDnieemvavelesll.ooppImmnecenrntetaaals!enndeeumuroro0tttoooxriciacicitttiyyviaatnnyddanaaddduudt!et cnnreeueurarosotetoodxxicihciaittbyyitssuttauutddiiioeenssohhfaamvvaeelebbeeoeef)nf~spccrooin,nddguuwcckateseddriiennpollarabtbeoodrraafttooolrrlyyowing cgageinesilstmtcaaatatilisooe.nfnfaaIenlcl ctaasr.nneddaTsllheaaecdcttsaame~tiiooeotifn~ofaarlel aceetcxtiappvrooitessyuuearrnenecdaaotdtmellpeecavvresee~lsassesssdeidimbmyihlaaitrbhittetoouDattehthivoeeer~cclr~oioi~pificmc[aea~llnaetelefafffleeoAccftftdsaapdnnriddnvgihhtaawvvaEeesndbbrpeeeoeepi~nnotr.iitnenccdRlluefuodsdleue!oddlwtaais~sfrgccooom~aScst~rliuutitddcisaiee!ssheuauffsvseiiencntggysi.wweaTlatdhteeeerdrseimmnaaeczozffneeescifttesestssettasnsrteffoorerrenslleucelaoatrrmsnmiiponnraggsesfaafennedddctbmmsyeeamttmhoheorirgDyyhee:iinrvn eaadlnnooiipsmmmeaalellssenvteeealxxlspp.AoodssdeeiddtivddituuyrriiEnnnggdddpeeovivn:eet,lloRpomepsmeunelttonsortfrro.aamss adu!~ have yielded inconsistent result~ or effects at higher dose level~, conducted] | RReessoouurrcceess CCoonnssu~ltteedd DDuurrii~ng RReevviieeww:: | s[,rNtNouotdotye::iMfdte4DnDtHHificccooanntiddouuncc(tteEeddPAaa 2ffo0o1cc6uu3ss)e.eddArreec~-oeomvvpaal[luue~atbto'ioo,e~nvawwlhhuiaiccthhiorrneelloiiefeddthuuepptooonnxiEEcPoPAlAo'gtssichhaaalzzIaatrerdrdaaatsusrsseeeswsosasmsmeennnottt aanndd kkeeyy || atu~.:~v identification (EPA 20t Ca). A oom~.~lete evaluatZon of the toxlcdogicaf literature w~s not conducted.] AAPeSSrTfTlSSuWoWrMiMnOOate((d2200C11h55)e.)m,iAAcssasslooscci(iaaPttFiioCosnn)oo:ffPSSettraafttieeuoaarnnoddocTTteearrnrrioittioocrryAycSSiodollii(ddPW WFaaOsst)tee&MMPaaennrafaiggueeommreoenonctttaOOfnffefiiccSiiuaalllssf..onate (POS) || Information Paper. Perfluorir~ated Chemicals information Paper. (PFCs): Pediuorooctar~oic Add (PFOA) & Perfluorooctane Sullen]ate (PFOS/ AAPeTTrSSfDlDuRRo.r.oa((2l2k00y11'55s))",. "'AARgegeternnicceyyve~fdoorrATTuoogxxuiiscctSSu1u5bb,sst2taa01nn5cc,eessfraaonnmddhoiDDtiwiosseetwaaowsseewx.RRpeeaggirisisstodtrryyfc._dleDDreraafsftt /TTooixxiipccoo2lloo0ggii0ccaa.llPrpPo~fdoiflfiele.ffoorr Perfiuoroall~yls." Retrieved August 15. 2015, from ~./www,atsdr.cdc.~!~~#~.~...0.....0.:~'~..d..~. AAnauutssittorranaallilaiarg~nuHiHedeaaalnlttchhePPorrnoottheecuctmtiioaonnnPPhrediannlcctiihppaarl!eCfCeoormemnmicetitteveae.l,uneesneHafoetrahtpte.hr.-((a220n01dt66)p).o.l""ye-efnnlHHueoearalokatlhhkySSlttaasttueebmmsetenantnt::ceIInnstteferoririmmuse in shs~tiiatteetpiovnAnevaswe~tswigtigugaihadtetaiiaoontnnchsse iinonnsnwAA.uhusgustotmrrvaaalliainaaw.,lh""'eenffarvroltiomhrmornemfeernetnfcacetvsahelueetss/fDoorcpuemrenatsn/dpfpaoslD-iflnutoerroianl-khyel substances for u:se alth-values-ahope po ~~ t. http:~tw~w.hea~th~nsw`.~v`au/environment/factsheets~D~cume~:ts/pfas~in~terim~hea~thva~ues~ah~. BCBihijjafaannngdd,, 5DS.J. EPPhCCvNNesRRmeaennns,seenJn,L...HBEuJJtePPniiheeottfeefrr,mmaaHnaM, GAACCPEErinMMcaeasns,ss,.(2JJ0'W~11)vv.aann"PddeeerrfrlHHuooooroorrannl,,kyMMlJJSuvvlaalnnonEEarrktk,e,sKKCWWauvvsaaenn ADDli}kjjkyk,l, SSCC CPCCrhhhoaaadiinunngct,LLieeDonnJnggtEithnhh--ADrDePeesO,pmoEee"ann3ndd-eeLnJneLttidHBHeeuepntpaeatCntihEiccoTSSfPftteeHMaaitMtcooeGss.iis"sPTaaroinnnxddciecHHonyl.ypop(og2oil0lcii1pap1liid)d~Seecmm"iPiieaaenrMcMfieauasioinnr1ol2yya3(bblk1yyy)l:IImmS2ppu9aal0ifoi-friin3nna0gg3teLLsiipsCoopsarruoostteeeiir.~AnIkyl Productioc~ fn APOE*34~eiden CETP Mice." Toxicological Sciences 23(1.): 290303. BsButututedenynnwhoilottfh,f. pJJo.,,tSaSsCCsiCCuhhmaanpngeg,r,fGGuoW WroOOolclssteeannn,.ePPsJJulTTfhhoonomamtfefoorirdnd,.Sp((22r00a11g22)u).e. "D"CCahhwrlrooennyiiccradtdsi.ie"ettaaLrryoysttioocxxoiiclciottyayyaan2n9dd3:ccaa1rr-cc1iin5n.ooggeenniciciittyy study with potassium perftuorooctane sulfonate in Sprague Dawtey rats." Toxicolog2 293: I ~15. CJCa-arPriioAonuul.,iRRg..n.acBB, VBVeeyLyrreaannBdid,z,eAcA, YY(aa2m0m1a5ad)d.aa,,PAAerfBBleeurrrcrerebobiai,l eDDyiZZaaacllikkodo,,(SSPFDDuAur)raannldde,v.eCCls PPaoltlloa~noo,. PP MMaarrcchhaanndd,, and profiles in breast JJ--CC milk, LLeebbllaanncc,, matermal and ,~-P Antigr~ac, maternal a~d ccBhhooLrredd serum of French women and Bizet, (2015). "Perfluoroalkyl serurr of French women and atthhceeidiirr{nPneeFwwAbbAoor)rnnlses.v.'"e* lEsEnnavvniidrroopnnrmmoeefinlnetts~Iinntteebtrnrneaaatfiisootnnmaallilk884,4: :77%1-8811. CCDOCC ((22001166))~. CCeenntteerrss ffoorr DDiisseeaassee CCoonnttrrooll aanndd PPrreevveennttiioonn., BBrreeaassttifeeeeddiinngg RReeppoorrtt CCaarrdd, CCExDOpCCos((u22r00e1177t)o).. ECCneevnintrteeorrnssmeffonorrtaDDliissCeshaaessreeicCCaooln~stn.rtrooUllpaadnnaddtePPdrreeTvavbeelnnet[sii,oonnJ((aCCnDDuCaC)r).y, FF20oo1uu7r~,tlhhVNNoaalttuiioomln~eaalOnRReeo.ppoerr1t oonn HHuummaann E>,'posure to Environmental Chemicals. Updated Talbles January 2017 Votume One. C(C2hh0a1an6n)gg.,, S".E..,vaBBlCCuaAAtlillloeennn.o,fKKsLLeAArnundmdrrelessp,,,DDtJJhyEErhohir:rdee,ssammnaandn..heRRpaFFtaaillcvvooc,.inAAicPParltoocvvheeennmccihhseterrr,.ieGGsWWin OOalslssseoecnni,.aJJtiLLonBBuuwtiteatnnhhhsooefffr,,um (23!6). 'Evaluation of serum !ipid~ thyroid, and hepatic clinical chemi.stries ;r~ association with so=rum PR -PagOe 7oSf11 22447777..00000099 STSTAATTEE 0077445577224488 TppeerrffolluuoorxrooooccittaanSncecsisseuulno[ficooennslaa(tteSeuo((bPPmRFigOOt,StS)e)idiinmnacccnyyunnsaoocmmroiollptggt)uuss mmoonnkkeeyyss aafftteerr oorraall ddoossiinngg wwiitthh ppoottaassssiiuumm PPFROOSS."" }T~oxicologicat Sciences ~Submitted manu:scri~: CCihnhedenur,ct,esTT,,~oxLLidZZahhtaainnvegg~,stJJr~-eqqssYYuauene,,dZZa--pqqopLLtvvo,,sW Wis XXiiniaa,,t,hYYe-4.lj uWWnagaonn,~f YYra-~yyoLLfi,i-,sSSp--r-qqinXXguu,*, R((e220p01r!22o)d)..uc`"tPPirrveeennaaTttoaaxlliPPcoFFlOOoSgSyee3xx3:ppoo5ss3uu8rr-ee 545.induces 545. oxidative stress and apoptesis in the ~!r~g of rat off-spring," ~roductive Toxico!ogZ 33: 538~ DDEvaaannliiussahhtiMMoininnioissfttrrhyyeoaoflfttthhheehaEEznnavrviidrrosor~anmnmdeenapttro([22p00o1s15a5)l.),oPPfeear~fhflleuuaoolrrtoahaltkbkyaylslaaettdeeddqussauulbibstsyttaacnnrcicteeessr:i:oPPn FFfOoOrAAd,.riPPnFkFi'OOngSSwaaatnneudr,PPFFsoOOiSlSAaA.n.d i `ground water. Environmental project No. 1665, Evaluation of health hazards and proposal of a grt~und wa[.er. Environmental project No. 1665, 2015. health 2~15 based quality criterion for drinking water, soiI and | DDpaeonrnglg,u,orGG.o-.o-H,.cH.t..aYnY-e,:s.HHulZZihhoaannanglg,e, LsLxZZphhoeesnnuggr,,eWWonLLiiJuum,,muYYn--.oHHloJJiixnni,cQQt-~yCCinHHaeed,ul((t2200m00a99)l).e. "C"CC5hh7rroBonnUiiScc eemffiffceeecc.tts"s Aoorffchives of || Toricology 83: 805-815. perfiuorooctanesulfonate Toxicolo.qv. 83: 805~8t 5, exposure on immunotoxicity in adult male C57BL/5 mice." Archives of | pDDeoornnfggl~,uoGGr.o.,.oMcMtMManeLLsiiuuu,.ifDDoiWWaatanerg'(9,P, FLLOZZShh)eenongng,,thZZeFFbLLaiilaaanngng,ceYYoHHf tJJiyinnp,,e((21200a111n1)d.).t""ySSpueubb2--ccchhyrrtooonnkiiiccneeefffifneecactdtuoolfft CS7BLS mice." | Archives of Toxicology 85: 1235-1244. perfluorooctanesuffonate (PFOS) on the Archives of Toxicology 85: 1235~-1244. balance of ~ype 1 and type 2 cytokine in adult C57BL6 mice. ' EEacFFdSSAA(P((F220O000A88)).).anEEduurrtoohpepieeraasnnaFFs.ooooSddcSSeanaftfeeittiyycAAOuupthtihonroiirotityny..ofPPeterhdfelluPuoaornrooeoolccottanannCeeossnuutllaffomoninaanttaeent((FsP~FiFOnOStS)h),e, ppFeoerorffdlluuocohrraooiooncc.ttaanncoiicc (Question No EFSA-Q-2004-163). acid (PFOA) arid their salts. Sc:ier~tific (Question No EFSA-Q~2004-163). Opi~ior~ of the Panel or~ Ccr~taminar~ts ia the Food chai.n. EsEugglefeoggnhhaytye:PPPPAaacnnoddmpMMarLLioosrrobbneerrof(.~2e02s10t1ti)l).m.a"t"AeAdnn iaanssasskeeesssswmmieehnntvtoaoflfuttehhseeIeenxfxepproorsseudurrfeerooofmf AANmmHeeArriNiccEaaSnnssdatttooa.pp" eerJrffoiuulroonrraooloooccttfaannee Exposure suifonate: ~.posure Science and Environmental Epidemiology. 21: 150-168 A comparison of estimated intake witlq values inferred from Science arid Enwronme[~tal ~idemiolo~ 21: 150-168, NHANES data.':' Journal of FFCrrhiiiasin~s-gNHeaasnnssieenn~B,.oBBd.~y((t1C99o66m1p1)o).s.iBBtoiooddnyy.WWaPaetdteierartrCCioocmsm,ppaa2rr8~t(mm2)ee,nl~t1ts6s9i~-nn1C(8;h1hiil,Udrreena:: CChhaannggeess DDuurriinngg GGrroowwt.ltq aanndd RReellaa~teedd Changes in Body Composition Peda,~"ics, 28(2), !69-!8t, `FFG~renoozmmemmleeB,,orH~o4,.v, iCCczMMeoonsysc,chh,B, MMKolMMeootrzorokvoiv,titzzW,l ~|VAAolllbkbeaal--,AAlle(e2jja0an1n0dd)rre.e~,PrSSe-BBooacenhhdmmeeProt~,stMMnatKKaiilrraaEnnxoopggollus,,urFFeFFtaaobbePerer,r, f|!lHHuaoanrnniinnbaibatlae,dl, OO Compounds (PFCs)." Environmental Science & Technology 44: 7123-7125. GenzeI-Bomviczeny, B Koletzko, W Volkel~ (2010t,. "Pre- and Postnatal Exposure Csmpounds (PFCs),!' Environmental Science & Technoto!2 44: 7123-7129~ to Pc[fluorinated GGHoeecrrhmmsaaaunnerMMliainnniidsstktrrryyeioosff.HNeSeatala!ttthhem((22e00n00t66)b).,yAAtsshsseeeDssrssimmnkeeinnn~tg ooWffaPPteFFrOOcAAomiinnmtithhseesiddroriinrn~kk(iiTnnrggiwwnakatwteaersrsooeffrttkhhoeemmGGieesrrsrnmiaoarnn~) of the `G}P4Gre,oe~rvrcmimhsaasi:nnoanuMaMelirinniEaiivsnstadtrrlkyyureaooitfsfi~H}o4enSeaatolaflttthhePmaFattTettnhihtneebDFFyreeitdhdnekeeriranaDlglriEWEnnaknvtivnieigrrroonWwnmimateehtnenttrthcAAeoggGmeeunnmiccdiyysesjJiSuouunnnbees(Tt22ar11in~,,ck22ew00sa00s6P6sle/errreerfkvvuoiiosmsreeo}dd~oic~Jstuusl~aioyynro~I1i33)c,,oa22fc00~i00dh66e~ (PFOA) and Perfluorooctane Sufonate (PFOS) as Examples. Pro~'isional Ewluatio~ of PFT in Drinking Water with the Guide (PFOA) and Perfluotoocta~e S:u!fo~ate (PF'OS) as Examples. Substances, Ped~uorooctar~oic acid HHeeaalltthh CCaannaaddaa ((22001100)).~ DDrriinnkkiinngg W Waatteerr GGuuiiddaannccee VVaalluuee PPeerffllluuootrooooccttaannee ssuullffoonnaattee ((PPFFOOSS).). SHHueeabals!ttthhanCCcaaennsaadd(aaP.,FA((22S00)11"66aa).)R,et"":rHHieeeaavlletthdh CCMaaannyaad2da7a,''ss20DD1rr6iin,nkkfiinrnggomWWaatteerr SSccrreeeenniinngg VVaalluueess ffoo~r PPeerrfflluuoorrooaa!lkk:yyllaatteedd hShSihtu[tepbpe:stf5ltos3ad,3[!~.d.deoosccuL:m(~PmeFneAtnctSci)t,oo"uuddR.ooer~tgriie/ddvooeccduumrMeeneatynst2d/223,775256063138686,6/fHi~Hemaelallthh .C-Caannaaddaa:.P.PAFSAS:-SSCcre~r.,. r~ien{;Ve~aVlanuius.i~ss.-.FnFaacgctt.- Sheet,pdf: CHHeoeanalsltuthhlaCCtaianonanaddDaa.o~c((u22m00e116n6btb).),. ""rPPoeermfflulhouiortorpoo:oc/ctetaaannleethSSyuulattfnoaannaattee ((PPFFOOSS))iinn DDrriinnkkiinngg WWaateterr., DDrraafftt hsystem:-systeme- ffoorr PPuubblliicc sCaonntseullactoionrs-~uaDtoiocnusm/epnert.i",ucfrroomnctane:sultonate/Gocument.ong php. PFPOFSO.S--PPaaggee 8Booff !11I 22447777..00001100 STSATTAETE 0077445577224499 "KKEaaxrrprrmomsaaunnr,,eAA.o,f1 IPeEErrrfiiclcsusooornni,,nEaBtev~daannChBBeaamv~eilec,la, lPPsOOthDDraaomrunegerhruuLdda,c,taMMtiAAounun:nee,L,eAGAvellGyslnyonnfn,~MaStcLLhiiggenndeslllHl=uGGmaLLniinnddMsistltrrkooamm,n,d((2S200e00r77u)}m. and a Temporal Trend, 1996-2004, in Sweden." Environmental Health Perspeciives 115: 226-230. "Exposure of Perfluerina~ed Chemicals through Lactation: iLeve~s of Matched Human Milk and Serum and a Temporal Tre~d, 1996-2004~ in Sw:eden~'~ Env~ronme~tal Health Perspectives 1 i5: 226,230. YKKiSimm,ShSSiK.n-,.K,.J,HKKLTTeeLL,eeee(,,20CC1SS1).KKaa"nnDggi~,stLLriTTbauatooi,onoKKfKKpaaennrnnlaaunno,.roKKcRRheKKmiiimm,c,aCClsKKbKKeiitmmw,,eJJeSSn !Ls.e.eeere,al PaPnSSdPPmaarirkkl,, fYYiWW omYYtohooeo,,sJJaYYmeHHaa., mothers YS Shiin, motl~ers aaJnnHdd implications Lee~ (2011). implications for prenatal and postnatal exposures." Environmental '='Distribution af perfluorochemicals between sara and for prenatal and pestnata~ exposures." Envirol~me!~tal Pollution milk from Po!lution t11h55e99::sa116m699e-~1!7744.. LLaauu.,. GC..., (2003). JJRR "Ex T"Th'hibbooddeeaauuxx,, RRGG HHaan~ssoonn,, posure to perfluorooctane sJJuMMlfoRRnooaggteeerrsds,u,rBBinEEg GGprrreeeyyg,,nMaMnEEc ySSttiaanrnntatootnn,a. nJJdLL mBBouuutsteeen.nhhoIf:ff,,pLoLs&AtnSSattteeavvleennssoonn,, || ee(2vva6al0luu3aa)t.tiioo"Enn.:x"p~ Toosxuiircec ol~ooga ipcearllfluSSoccriioeeonncccteea8sne7744s::u33ff88o22n--a339t9e22.oduring pregnancy in rat and mouse, ti: postnatal | LeLixiuup,,oJJs.,urJ3eoLLii,f, YperLLiliuuu,,orHHiMMnaCClhehadann,c,oYYmpZZohhuaanoo,d:sZZfGCoaraini,eYYwbWWourun,,s.((220011E1n!)v.)i.r'"!oCCnoommmepnpatardiisnsoeorm~naotoinnoggneeaslsttaa3t7t.iioonn12aa0nn6dd-1ll2aa1cc2tt.aattiioonn | eposu~e of perfluo~ii-~a~ed compounds :~or r~ewboms." E~-}vironmer:,t i i}temat:ior~a! 37: i 206~i 212~ ET et J rL,~eoocppeeepzzt--oD-rDosvoa\claa,ln, SSb...e,,RRmodSSiaafltiggeaadddoob,,yAApeLLraalffuuuoeernnotteoe,c,t((a22n=0e0161)s6.u).l"f''foT'nhhaeeteeexx(ppPrrFeeOssSssi)iooninn ooaffdsusleetvveemrraaalllerreerpaptrrsoo.dd"uuGccthtiievvmeeohhsooprrhmmeoornneee165: || 488.497 receptors 488-~497, ca~q be modified by perfluorooctane su!fonate (PFOS)in adult male rats.'" Chemost2here t55: 1rLre4eu8ppe.rrbookddeuurcc,ttiiDoo,n,n and cross-foster studies of perfluorooctanesuifonate (PFOS) in rats."Toxicology 215: 126- MT Case, RG York, JA Moore, KJ Hanson, JL Butenhoff, (2005b): "Two,generation and crose~fos~er ~tudies of pe~luorooctar,esutfona~e (PFOS) i~-.. rats~ '~ Toxicolo~:~ 215:126.,. eLLxuupeebobkskeuerrr,e, DD1..,. pRReGGrfYYlooorrrkko,ocKKtJJanHHeaasnnussleoonn,naJtJAeA(MMPooFooOrrSee,). JJinLLSBlBpuurttae.egrnuhhelo-ffDf,,a((w22l00e00y55raaa)t.).sd"NoNeseoeon-naratetaasllpmmoonorsrtteaaliiatyynffrrobomimociinnheuumt~ieecrraool and pharmacokinetic parameters." Toxicology 215: 149-169 exposure to parfluorooctanesulfonate (RFOS) in Sprague-Daw}ey and pharmaokinetic pa.rameters." Toicoior4)L.._215: 149~169. rats:dose-response and biochemical "LLvGv,,lu2Zc..~osGGeiLa,i,ndYY LLLii,ip,iGCd HYYoii~nmgge,,osJJtCCahhseeinrst,. iTTn ACCdhhueelntr,t.RJaJtWWeIies,LIYmpaLLiiinnr,,eYYd JJbiiyaannEgga,r,yYY-LW WiafaenngEg,xpBBosSSuhhruue, tBBo XXPuue,,rfSluXXouur..oo((c22t001a13n3)e,). S"GufIoJncaotse.e"anEdnvLiirpoidnmHeonmtaeloTsotxaiscisolinogAyd2u8l:t R53a2t-5is42i.mpaired uy Early-Life Exposure te Peffiuorooctane Sulfonate." Environmental "toxiolo~ 28: 532~542. tMMheDDMHHat((t22e00r00o68)f).~PrMMoiipnnnonesesseoodttaaRuDDleeeppsaarRrettmlmaeetnnitntgooftfoHHeHeaealaltlthht:hSSRttiaasttkeemmLieemnnitttsooofffNNGeereeoddunaadnnwddatRReerea.assNoonTnaPabbi(l2ee0nn1ee6sas)ss.((SNSOaOtNNioAAnRRa)l) iinn tTTPheooerrfiiMlcuooaocotrotoeolloroocggotyyfanPPPorrriooocpggoArracasmiem.dd (RDDP~urFalaeOflsASS)RyysoesrtltaeePtmmienaratgfitli~ccuooRRHreoeevovaicieltethwawnReoo~fisSlIkummlmLmfuiomunncnaitttosoetoxo(ixfPciGcFiiOrttoSyy)uAA.nssdsswoocacitieaatrte.eNddTwwPiilth(h20EE1xx6ppoaos)s.uurNreeatttiooonal Perfluorooctanoic Acid (PF:OA} or Pedluorooctane Su~fonate (PROS}, IMMnODcoHHrp((oMMriainntnneeeHssuootmtaaaDDneeEppqaaurritmvmaelenentnttooffDoHHeseaelatlChth)a.)lcu((2l20a01t17i7aoa)n).s. i""MnMtDoDHDHerHHieevaaaltlttihhonRRoifissOkkr.AaAslssseResesfssemmreeennnttceMMeDetothhsooeddsss(ttoMoay 2011, vised 2017)." from ito: healt state, mn.usidivs/ehirisdguidancelhedrefguide pdf !~co.rporate Human Equivale~t Dose Calculations into Derivation of Oral Reference Doses revised 2017)." from [!:~f.# i/www hea th state mn us/d vs/eh/r sk/!~ uidance/hedrefgA!~A~2~d~. (May 2011, MPMFDDOHHS((22a00n1dt77bPb)).F. O((MAMiinan~nnedesslooitstaaUsDDeeeppiaanrrtttmhmeeenDntetrooifvfHaHetaieloantlthho)f} BBHauaccmkkaggnrrooHuuennaddltDDhoo-ccbuuamrsenenedtrf:Wf:aTtToeoxrxiiccGooukkiiidn~eaetntiicccaMMVooaddleeulles:ffoorr Pros and PFOA and its Use in the Derivatio~-~ of Human Health~based Water Guida~ce Values. NpNreeolljsseoocnnt,.dJJa..ta((22b001a16s6)e.).d""PoPneerrJssuoonnneaall9.CCo2om0mm1mu5nuiMneciecatatitiinoognnArrgeegegaanrrdddaiinnaggnMMdDDMaHHteMMriNNal((sEEfaaossrtttMMheeetAtrrdoov))iPPsoFFrCCy bbPiiaoonmmeolornittiatootrfhiinengg ptEEnrnpovvjieirrcoot~ndmmaeetnanthteaabalallsHtHeehedaasltlotathhtne.TTJrurmarai~ccekkuii9nnsggd2ia0avnn1dds5/BBMnliopeommeeotdoin~inigirttooaArrcigiI~kengignndPPagrrlooagpgn2rrada0anm1mMg5.iateurnieamlsatfeorritshlesApddtv.i"sory Pa~el to the .ht~#:flwww. hea Ith..state. n~n, usidivs/h#cd/trackir~.,"~uZPanel/2015Junemater.ials NENxTTpPPos((uSSreeeppttteoemmPbbeeferlru22o00r11o66)o.)ctNNaanatctiiioocnnaAalcliTTdooxoxiriccPooeccraofllloouggoyyroPPorrcootggarnraeammSuMMlofoonnnoaogtgerr.aapphh -- IImmmmunuontootsoixciciittyy AAssssoocciaatteedd wwiitthh Exposure to Perftuoroocta~oic Acid or Pedluorooctar~e Suitor]ate. PP~ROO.SS~ -PPagaege99ooff 1111 22447777..00001111 STSATTAETE 0077445577225500 Q1Qsiiuua,, PLL.o,.t,eXXntZiZahhlaan~Tgag,r,gXXetZZfhhoaarnrP!gge,,rfYYuZZohrhaoanongcg,t,aJJneGGuSu,u. fMMonCCahtheeen-n,I, n2ZdZuZhchaeand~gg,R,epXXrWoWadauncngtg,i,vSSe-~LDLysWWfauannngcgl,,io((n2200i11n33)M.)a. l""SeSeMeritaec~lei.C"ell Toxicological I~ a Potential Tr~xicolo~qical Scisnces 1351). 229-240. Target for Perfluorooctane Sciences 135(i ): 229-240, Suffonateqnduced Reproductive Dysfunction i~q Male RRPIFtVVOMSN... NNAaatptiirooonnpaaollsaIInnlsstftiiottruuwtteaetffoeorrrPPquuubabllliiicctyHHseetaaalIntthdhaaarrndidds ttihnheeacEEcnnovvriirdroaonnnmcmeeennwtitt((h2200t1h10e0).)WaEEtnnevvriirrFoornnammmeeenntwtaoalrl kirissDkkirlmaimicititvsse.ffoorr Report PFOS. Report 601714013/2010. A proposal for water 6017 I4013/2010. q[4ali~y standards n accordance with the Water Framewod~ Directwe. SScchheerr,. DD. PPeerrssoonnaall CCoommmumnuincaictaitoionn.. ((2200116B).). PPFFCCss iinn FFODLL SSttuuddyy.. `Seacal, A, PJ Thomford, KJ Hansen, GW Ofsen, MT Case, JL Butenholf, (2002) "Subchronic toxicity S.eacat A, PJ Thomfo~d, KJ Nansen GW OIsen, MT Case. JL Butenhoff (2002) "Suhchronic toxicity s`stutuddiieess oonn ppe~rrf~lfuuoorreoooccttaanneessuuliffoonnaattee ppoottaassssiiuumm ssaalltt iinn ccyynnoommoollgguuss mmoonnkkeeyyss.?"' TTooxxiiccoelloo~giliccaal! SScciieenncceess 66.249-264. 68: 249~264. SS"eSeauacbca-atct,h.rAAo.n,i cPPJJdiTTehhtoaomrmfyoftorordxd,i.clKKyJoJ fHHpaaonnstseaonsn,s iLLuAAm CCpleleermfmleeunno,,roSSoRRctaEEnlleddsrriiuddlggfeeo,,naGCtRRe Eicombe, JL Butenhafl IEn lrcaotms.b"eT,oxJiLcoBluotgeynh1o8f3f:, (2003). (121070-31)3. 1 . || "Sub-chronic dietary toxicity of potassi[~m perfluorooctanesulfonate in rats." Toxicoloq3 183:117-131. TTPrCCoEElQQa.c.i((v22e001C16o6)n.),ce""TnTteerxxaaatssioCCnoomLmemvmiesilssssii(ooPnnOLooSnn).EEnnvvfi}rrrooonmnmmeennttaa~l QQuualailtityy.. TTeexxaass RRiisskk RReedduuccttiioonn PPrrooggrraamm ((TTRRRRPP)) hgitoovsiiwwrwteoemqteexdasi. alion'tofioehlims Protective Concentration Levels (PCLs).", from https : llwww. tc~ovlremediationltrr#~tri:u.#cfs, htm l. Thibodeaux, J. RG Hanson, JM Rogers, BE Grey, BD Barbee, JH Richards, JL Butenholf, LA Thibodeaux, J., RG Hanson JM Rogers. BE Grey, BD Barbee, JH Richards, JL Butenhoff, LA SSt~eev~e,ennssoonn, CC LLaauu,. ((22000033)).. "'*EExxppoossuurree ttoo ppeerdf~l!uucorrooooccttaannee ssuultffoonnaattee dduurriinngg pprreeggnnaannccyy iinn rraa~t aanndd mmoouussee.. 1. maternal and prenatal evaluation. Toxicological Sciences 74: 369-331. i mate.rnal arid prenatal eva~uafions." Toxicologica} Sciences 74: 369-381. "TThhoommffoorrdd,, PP.. ((22000022)).. 110044--WWeeeekk DDiieettaarryy CChhrroonniicc TTooxxiicciittyy aanndd CCaarrcciinnooggeenniciciittyy SSttuuddyy wwiitthh PerfuorosctaneSufonic Acid Potassium Salt (PFO: T-6295) in Rats. Final Report, Volumes HX Pedluorooctane Sutfonic Acid Potassium Salt (P~OS: T-6295) in Rats, Fina! Report. Volumes IqX Covance Study No. 6326-183 C~vance Study No. 6329~!83. concentrations in drinking water. UURnenigituteelddatKKiioinnnggsdd2oo0mm0..0/DD0rr1iinnskkiipnneggc~Wiaf,~titaecoterrPIlnFnssOppSeecc(ttpooerrraaftteleuo((2r200o0o07c7)t.)a,nGGeuusiiuddlaapnnhccoeenaootnne)tthhaeendWWaPattFeerOr ASSuu(pppppelrlyyfl((uWWcaraottoeecrrtaQQunuaoliaiclittayyc))id) Regulations 2000/0I specific to PFOS (perfluorooctane sufphonate} and PFOA (perfluorooctanoic acid) concentratior~s in drip, king water. UUSS EEPPAA ((22000000).). UUSS EEnnvviirroonnmmeennttaall PPrrootteeccttiioonn AAggeennccyy ((EEPPAA)).o OOffffiiccee ooff WWaateierr.~ MMeetthhooddoollooggyy ffoorr DDeerriivviinngg AAmmbbiieenntt WWaatteerr QQuuaalilittyy CCrriitteerriiaa ffoorr tthhee PPrrootteeccttiioonnooff HHuummaann HHeealatlthh.. EEPPAA-~8.2822-28-B-~0000--0O0044., OOccttoobbeerr 2000. UUSS EEPPAA ({22001111).). UUSS EEnnvviirroorn~mmeennttaalt PPrrootteeccttiioonn AAggeennccyy ""EExxppoossuurree FFaacct!oorrss HHaannddbbooookk.~ OOffffiiccee ooff RReesseeaarrcchh aanndd DDeevveellooppmmeenntt.,'"~ ffrroommh.tbt~.p~st../p/..c~f.;~p[u.~b[.~e.~p..a..~g..o~v.~i`n..c`.eaa.~l`r~i9s.yk~i[r]ceecao/rrisdkiJsrep~lradyis#cj~f-my.?.~dfemi?dd=ei2d3=263265225.2` tos lw epa,ovisiteslproduction/fles/2016.05/documents/hesd.pfos finalplain po. DUUoSScuEEPmPAeA.nt((22f00o1r166P)ce.r).fl""UuUoSSroEEonncvtviairrnooennmSmueelnnfttoaanllatPPreroo(ttePecFctOtiiSoo)nn.AA" ggeeRnentccry-yi-evOOfeffdfiiccMeeaooyff1WW9a,tae2tre0.r16HH,eeafalrlttohhm EEffffeeccttss SSuuppppoorrtt Document for Pedluorooctane Su/fonate (PFOS),." Retrieved May 19. 2016, ~rom htt ps://W w,#~. e p~Lit~e~,~prod u ct io r~, filed2016~0otdOCLt:n~ e~ts/hesd_Dfos itos fume epa.Govisites/producton/tes/2016-05/documents/pfos. health advisoryfinal-piinpal. UUSS EEPPAA ((220011664d).}. ""UUSS EEnnvviirroonnmmeennttaall PPrrootteeccttiioonn AAggeennccyy o- OOffffiiccee ooff W Wataeter.r. DDrriinnkkiinngg W Waatteerr HHeeaalltthh AAddvviissoo~r-yy ffoorr PPeerrffll.uuoorrooooccttaannee SSuullffoorn;aattee ((PPFFOOSS).)."' RReettrriieevveedd MMaayy 1199,. 22001166,, f~rroomm ~tt::)s :l/www,e,,~La~~roduction/files/2016~OS/documentd~:~fos health SWWiapanemsb,baauMugghMha,,rtJJi..n,,,RRKWWDaSSsee,ttzzeJerCr,, DAAeMMWitPPtii,trruuMzzzzeSelt~lrIoyo,n,aJrJ,LLiRiuu,,JDDudMMsoRRneei,fif,.KANNCCHoKKuitceekiin,nssCitrreeLuuaeeurr,,, (NN20CC1h3h)ii.nngg,",DYYosiWWmaeanlngrgi,,c:NN TaSaonnixpcciehhcsooo,rlriioMnngggiMco~aaflrit~Sin~nc.vriiivKevenoDcaaeannssdd1J3iit~6nCvvDii3tetr0o~o8,,-:s~s3/titt2uut,7td.iMieessSfotoryrrnp!a}ereorrfflRluuooJrruoodoosccottanan,nooKaaAtteeHaaonruiddckpp,eerCrffllu~uoaourroo, oo(cc2tt0aa1nn3ees)suul"lDffooonn~aaitntee~.,e""tric Toxicolo~3ical Sconces 136: 308~327. PPEROOSS-- PPaaggee 11000oif 1111 22447777..00001122 STSATTAETE 0077445577225511 | ErTrm 10rn ros W Waanngg,, LL..,, YY W Waanngg,, YY LLiiaanngg~, JJ LLii,, YY LLiiuu,, JJ ZZhhaant]gg,, AA ZZhhaanngg~, JJ FFuu,: GG JJiiaanngg, ((22001!44)).. ""PPFFOOSS ii~ndduucceedd ~liippiidd | metabolism d s~urban.ce~ i~ BALB/~ m~ce ~hrough i~h~bitio~ of low density lipoprote~ns excretion." Scientifio Re:po~,~ 4; 4582. | | 22447777..00001133 STATE 07457252