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AR226-1377 rr ee hewn PRRRE36_1377 | POND bo . E. 1. Du PonT bE NEMOURS & CompANY WILMINGTON, DELAWARE 19898 POLYMERPROGUCTS DEPARTMENT | | | ` TO: R. L. RICHARDS | FROM: J. W. BAINESQi YYTg N T30I 10 RSMSITHH ou H. E. SERENBETZ M. A. SMOOK 2D Hara, A. LI.. DDADEE- Fer &F B. W. KARRH - ER RB.. LC.. RMCHODKEUSSIC-KTF- CR&D, HASKELL J. H. TODD - WASH. WORKS April 1, 1981 . ' AMMONIUM PERFLUOROOCTANOATE (C-8) RANGEFINDER STUDY |( Dr. R. E. Staples, Teratologist, and Taisan'Chiu, Pathol- |{ oopgFriesgttnh,eantfOrroaramltsHR.aasnkgeTelhfleiyndLeacrbonvcSiltsuuiddteyeddoft3hpMaetrofntlhuMeoarrstocuohdcyt2wa7naotsaotevraelv(iiCde-8w)arndeisnuclhtasc tshoeleopbusreprovseed offetutshiseyetecsthavnagses twoerdeetedrueminteo tthehe Cu-p8p.or Sdionscee letvheel ftohre eayessubsofequfeenttuseosralfrotmeruanteoxlpogoysedstu(dcyontirnolr)atsr,ats3.M did not examine gbne 41g5z0ilmg/63kMgt/podlaadyne,sterttmoheinsestaarmatenoat-sheeftfnheeecwttoorplaeldvoestlee|ralTtehoveellogcoyipnstdthouesdeyRwalinegtveehlfirnawtdiselrl Study. Other dose levels will be 15, 5, 0.05 and 0 mg/kg/day. the second3Mweaerek osftiAlplripll.anning to communicate to their employees bienintghe tbhelTohCoe-d8reobflhoarasotdsb,eleenvTewlseonfmteoyr-cfotinhvfeeusfipeopmnamlweoafsratqthsueotfceeoddncef25nrtomrmgam/tekimgoo/nrdyaofyasCi-n8 dtuheriRnagngbelsfinvdiestreSttuhdayt.bloTohidslweavselsinwaerrreori.n c3heM ctaonlgdeDro.f S1t-a3plpepsm for the low and high dosing levels, respectively. tests thatItthheadhablefenlpirfeevifooursldyecaeystaobflCi-s8hedinwipatlhebortaht3blooadndwaDsu Pont 7na-n9t)dayrsats(,afsteurggeexsptoesdurteh)a.t tEhaerldieecray3Mrawtoerwkawsitmhufchemhailgeher(.notIpnrefga-ct, miantearni'ailntwraasvenaocucsouinntejdectfioronitnestthewiftehmarlaediroaatctuirvieneC-in8'a, amllattteher co-f8 ~ - -: EID079758 ooo ll3 Ko L. Kavancwy - pan my : miuutes, In a i(neqtuhieviarlenbtlootod 90-day feeding test with 300 ppm C-8 dn chet diet daonsdinfgemaalbeout (n3o0tmgp/rkegg/ndaanyt)), rmaatslehardatsonlhyad 0.3285ppppmm.C-8 breeiancgtiocnonTsthoiededgroresediantgbywdiHitafhsfekreCel-nl8ceiisnbedatewvseeiergnynimnsagtlrenaengwaenldypphfelenamoanmlneeendornas.ttsudiTiehnsi.stheisir JWR: 1dr . - 3 EIDO79759 00014