Document 06QRm9Eg5k7rQvMN9eqg03QNJ

THE DOW CHEMICAL COMPANY November 25, 1986 MIDLAND MICHIGAN 48674 Ms. Carol Stack CHEMICAL MANUFACTURERS ASSOCIATION 2501 M. Street, N.W. Washington, DC 20037 Dear Ms. Stack: Attached is a copy of a letter I received from Mr. Bennett regard ing the Vinyl Chloride Study. Dr. Ted Torkelson requested that I send you a copy of the letter. If you should have any question, please contact: Dr. Ted Torkelson 3865 John Ln Midland, MI 48640 Phone: (517) 835-1354 Sincerely, Angie Grzegorczyk Epidemiology, H&ES 1803 Building Midland, MI 48674 Phone: (517) 636-2718 Attachment CMA 006421 Hillhouse Site PO Box No 4 Thornton - Cleveleys Blackpool FY5 4Q0 Telephone (0253) 861 632Direct line (S cretary 861370) (0253) 861444 Switchboard 6 632Extension Number Facsimile (0253) 864887 Telex 67433 Idplast Clvlys Imperial Chemical Industries PLC Medical Department Mrs Angie Grzegorczyk Epidemiology, H & ES The Dow Chemical Company 1803 Building MIDLAND Michigan 48674 USA Your ref Our ref BB/MO Date 19 Nov 86 Dear Mrs. Grzegorczyk, FINAL REPORT ON CMA UPDATE OF VINYL CHLORIDE STUDY Thank you very much for sending me a copy of the above report, together with a copy for Sir Richard Doll. I have posted Sir Richard's copy on to him. I very much appreciate receiving this report, in which I am vary interested. Yours sincerely, /]/tt t. ijL xt, B BENNETT M.A. M.B., B.Ch., B.a.O. D.Obst.R.C.O.G. D.I.H., M.F.O.M. CMA 006422 UVER ANGIOSARCOMA GASES GnNFUBfflAL WEX/ASL - ASL_AH)RESS CmCULATICN OF REGISTER AEWC Dr A Ross Air Products, Allentown, Pa, USA BAG3WW Dr I MM Norsk Hydro, Newton Aycliffe, IK RAND Dr P R Cancer Control Agency of British Golunbia, Vancouver, Canada BARNES Jnr W C Monsanto, St Louis, Missouri, USA BARR Dr J T Air Products, Allentcwn, Pa, USA BARRAT Dr G AECRP, Conmentry, France BAXTER Dr Peter EMAS, London, UK REAUPRE M Governnent of Quebec Cancer Registry, Canada BENECH Dr M Naphtachimie, Lavera, France BENNETT Dr B ICI HUlhouse, IK BERIAZZI Dr P Inst of Occupational Health, Milan University, Italy HKSCHF, Dr Dynanit Nobel, Troisdorf, Germany BI5H0P Dr C EMAS, Bootle, UK BORKELLI F E Georgia Gulf, Delaware City, USA BOXER R W Formosa Plastics, Delaware City, USA BURGESS Mr David ICI Anericas, Wilmington, Delaware USA BYREN Dr David Kananord, Stockholm, Sweden CARTER Dr J T EMAS, London, IK CELLA Mr C Enichem Polimeri, Milan, Italy CHANCE Mr M IQ Runcorn, IK CLAUS Mr P G AM, Brussels, Belgian CLAYTON Mr H Norsk Hydro, Newton Aycliffe, UK CDNIASSOT Dr J C Chloe Chimie, Saint-Fors, France DAVIES Mr J G ICI, Everberg, Belgian (2) DE SLOWER Dr Solvay & Cie, Brussels, Belgian DE VOS Mr A J ICI Everberg, Belgian DIETZ Dr H W B F Goodrich, Akron, Ohio, USA DOLL Sir Richard Imperial Cancer Research Fund, Oxford University, IK DOMBRCWSKI S L Dow Chemical, Midland, Michigan, USA DUPONT Mr G AEME, Brussels, Belgium QMDEER Mr H VKE, Frankfurt, Germany ERTST Dr W Berufsgenossenschaft der Chemischen Industries, Numberg, Germany FALK, Dr H Chronic Diseases Div, US Dept of Health & Hunan Services, Atlanta, USA FERQJSON Dr D M ICI Americas, Wilmington, Delaware, USA FORMAN Dr D Imperial Cancer Research Fund, Oxford University, IK ERASE R W DiversiTech General, Akrcn, Ohio, USA ERIEDEL Dr H P Berufsgenossenschaft der Chemischen Industries, Heidelberg, Germany GOLBERG Prof L Duke Utiiv Medical Center, Durham, North Carolina, USA GOSZTONYI Jnr Dr R E Tenneco Chemicals, Piscaraway, New Jersey, USA GOTIESMAN R T Tte Vinyl Institute, New York, USA HARRIS Dr W D Uniroyal Inc, Mlddlebury, Connecticut, USA HILL Dr G B Alberta Cancer Board, Edmonton, Canada (HUMAN Dr D W Diamond Shamrock Corp, Dallas, Texas, USA HINDERER Dr R K BF Goodrich, Cleveland, Ohio, USA HODGSON Mr J EMAS, Bootle, IK HOGG Dr W A Imperial Oil Ltd, Sarnia, Ontario, Canada HUABD Dr J K University of Otago School of Medicine, Wellington, New Zealaid HUMPHRY Dr N F ICI Australia, Melbourne, Australia JAUVERT Mr J Chloe Chimie, Paris, France JERVIS Mr H R ICI Mlllbank, London UK KARRH Dr Bruce Dupont, Wilmington, Delaware USA KKEUGER Dr R A BF Goodrich, Akron, Ohio, USA LALGINE Dr J P Solvay, Brussels, Belgian LAMMM Dr John Dw Chemical Europe, Hopgen, Switzerland LAWRENCE Mr J SPI, New York, USA LAWRENQE-JONES Sir Christojiier, Chief Medical Officer, Id, London IK LEE Dr F I Victoria Hospital, Blackpool, Lancs, IK LEIBACH Prof VK University of Bonn, West Germany LEVEQUE Dr G CDF Chimie, AZF, Bully-les-Mines, France LEVISCN Dr D A St Bartholomew's Hospital, London, UK LEWIS Dr P Chanical Industries Association, London, UK LOLTVUR Mr Solvay, Brussels, Belgian LUSSATO Dr J Arochem, France , ' '^ Q06423 -I- WFX/ASL - ASL ADDRESS,2 mattJ.ard Dr J M Medizinsche Abteilung, Luzern, Switzerland MALHOTRA Anna Statistics Canada, Ottawa MALIOWI Prof C Institute di Oncologia, Bologna, Italy MATIEE Prof In Ffedil-Anic-S, Milan, Italy JttOTUSSI Dr R Montedison, Milan, Italy MUDIEION D Norsk Hydro, Newton Aydiffe, IK MDKKA Mr Neste Oy, Espoo, Finland MONIESANO Dr R IARC, Lyons, France Mom Dr A A Duperial SAIC, Buenos Aires, Argentina MJNN Dr A Montanto, Brussels, Belgiun MUNOZ MXJTCN Dr M Rio Rodano, Madrid, Spain MacSWEEN Prof RNM Western Infirmary, Glasgow, Scotland NAKAMJRA S Japanese FVC Association, Tokyo O'SUILIVAN Dr JJ ICI Runcorn, UK OLSON H G VC Safety Association, Louisiana, USA CHEN Dr R Trades Union Congress, London, IK PADELE Dr G M ICI Central Medical Group, Alderley Park, IK PAGLIAUINGA Dr S Montedison, Milan, Italy POPPER Dr Hans Mount Sinai Medical Center, New York, USA POSSEERG Dr J Wacker-Chemie, Munich, Germany HJEQJ Dr A M Atochmn, Brignoud, France EURDHAM Dr J Canadian Centre for Occupational Health & Safety, Hamilton, Canaia RAMBAUD Dr J SP Recherches, Antcny, France RANGNES P Norsk Hydro, Porsgrunn, Norway RICHARD Dr P Rhone Poulenc, Roussillon, France ROBSCN Mrs D Saskatchewan Cancer Foundation, Regina, Canada RCDRIGUES Dr MJF ia, Sao Paulo, Brazil ROJSH Dr G Monsanto, St Louis, Missouri, USA RUIY Dr J Atochem, St Auban, France SAIO Dr J NIOSH, Cincinnati, USA SARAGCI Dr R IARC, Lyons, Frarve SCHEFFERS Dr M L DSM/CVMD, Geleen, Holland SOHEPER Dr H University of Manitoba, Winnipeg, Canada SERDWE Dr D Diamond Shamrock, Dallas, USA SHAH Dr Has CMA, Washington DC, USA SIGRIST Dr J Shell Chimie, Berre L'Etang, France 3CTH Dr E Division of Environmental Health, World Health Organisation, Geneva, Switzerland SHIH Dr P M Llandough Hospital, Penarth, UK SPIRXAS Dr R NCX/NIH, Bethesda, Marylanl, USA STAFFORD Dr J Somerset, UK STAHECKER Mr BASF, Ludwigshafai, Germany TAMBURHO Prof CH University of Louisville, USA TER HAAR Dr Gary Ethyl Corporation, Baton Rouge, Louisiana, USA TEWIESCH Dr B ChenrLsche Werke Hals, Kreis RecklinghaaEen, Germany THERIAULT Dr Gilles McGill University, Montreal, Canada THLESS Prof Dr AM BASF, Ludwigshhafen, Germany THIIS-EVaeCN Dr E Norsk Hydro, Porsgrunn, Norway THWSON Dr D H Cancer Treatment & Research Foundation, Halifax, Nova Scotia, Canada TEKDOIR Dr W Shell, An Den Haag, Holland VAN DER tRWE Dr H J AECI, Sasolburg, South Africa WAILACE J R Esso, Sarnia, Ontario, Canada WAIIEMA1E H BF Goodrich, Cleveland, Ohio, Usa WEJDUNG S 0 Kananord, Stockholm, Sweden WHEELER Dr D J ICI Hillhouse, UK WISHER R N Union Carbide, South Charleston, USA WHISTON Dr J ICI HilHwme, UK WHITE K H Duperial, Buenos Aires, Argentina WTLTT'SKI 0 Electrochemical Industries, Acre, Israel WILLIAMS Dr EKT BP Chadcals, Penarth, IK WD.SCW Prof R Harvard University, Canfcridge, Massachisetts, USA WRIGHT Dr A P ICI Wiltcn, UK YORK J ICI Everberg, Belgiun From: Dr B Barnett, Medical Department, Imperial Chemical Industries Pic HUlhouae Site, FO Box 4, Thorntoo-Qeveleys, Blackpool EY5 4Cp, UK* CHA 006424 February 1986 CONFIDENTIAL REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVER DUE TO EXPOSURE TO VINYL CHLORIDE PREFACE : Acknowledgments, significant changes and comments REVIEW DATE 1 JANUARY 1986 1. The new cases in the Register are the following : France Germany UK 18 25,24, 25, 26, 27 11, 12 2. There are amendments from the previous Register against the following cases: Germany 21, 22 US 36, 38 3. I would like to thank Dr De Sloover, Dr D M J Williams and Dr Friedel for informing me of new cases. 4. For the case corrections I would like to thank Dr Friedel, Mr J T Barr and Mr R W Frase. 5. For other corrections and information, thanks to Dr D Forman, Mr J T Barr, Mr T H Sutherland and Mr N F Humphry. 6. I should be very grateful if all recipients of the Register could continue to keep me fully informed of any new cases, or, if they should hear of other Companies who have acquired a case of ASL, it would be muchappreciated if I could be notified by the appropriate person. It is extremely helpful if new information is supplied in tabulated form, using the headings in the Register as far as possible. 7. I would like to thank the many people who have suggested research topics, and should be grateful if I could be kept up to date. 8. I shall be happy to supplyto any recipient of the Register a copy of the Paper "Exposureto VinylChlorid andAngiosarcoma of theLiver: a report ofthe Register of cases" by Dr David Forman,myself, DrJohn Stafford and Sir Richard Doll, published in the British Journal of Industrial Medicine, November 1985 (42; 750-753) Dr Brian Bennett Medical Department Imperial Chemical Industries pic Hillhouse Site P 0 Box 4 Thornton-Cleveleys Blackpool FY5 4QD England ` February 1986 CM 006425 IMPERIAL CHEMICAL INDUSTRIES PLC WPX/ASL_2 - LANCIOCASES,4 Index Table Sequence Belgium Canada Czechoslovakia LIVER ANCIOSARCOMA CASES (REVIEW DATE - I JANUARY 1986) Page 1 2-3 4 ASL Case Numbers by year of Death (Table 6) ASL Case Numbers by year of first exposure (Table 7) Page 42 43 France Germany Italy Japan Norway Sweden UK USA Yugoslavia Incidence of Cases per annum (Table i) Distribution of Cases by Country (Table 2) 5-8 9-14 15 16 17 18 19-21 22-28 29 30 31 Western Europe PVC Producers - Start-up Dates vs ASL Cases (Table 8) USA PVC Producers - Start-up Dates vs ASL Cases (Table 9) Canadian PVC Producers - Start-up Dates vs ASL Cases (Table 10) East European PVC Producers - Start-up Dates vs ASL Cases (Table 11) Japanese PVC Producers - Start-up Dates vs ASL Cases (Table 12) South & Central American PVC Producers - Start-Up Dates (Table 13) Australasian P,VC Producers - Start-up Dates (Table 14) 44 45+46 47 48 49 50 51 CMA 0 0 6 4 2 6 Pattern of Cases by Factory (Table 3) 32 Latency Periods (Table 4A) Distribution of Latency Periods (Table 4B-4H) 33 34-40 `' Annual Geographical Incidence (Table 5) 41 tPa I . f #ELC1UM IMPERIAL CilWIJCAL INDUSTRIES HC LIVER Augluearcooa Cause " (Weview lists i I January L9B6) WFX/ASLJZ - LANGtUCASES.b l 2 3 4 56 ft 9 10 II 12 13 14 16 16 COUNTftY AHD REFERENCE NO HAHE OR INITIALS DATE OF |[TH COMPANY TACT*JET FIRST VC EXPOSURE DATE or DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS TEARS OP EXPOSURE DATE OP DEATH HISTOLOGICAL COMPIRHATION ESTIMATED EXPOSURE 1 EVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS ftEI.G 1 tiH 01 12.01.1) Solvay Jansppa 00.QJ.5tt 00.05. 76 63 Ift U 29.06.76 Tea High Au toe leans r Driller in a Hepatic testa 14 yrs foundry in Oct 1974 l9Sd-)96ft (2 yre> were uurei1. exposed it* Polywurker 200 |t| 3 yes Fsraer 05 yre> Retired Feb 1975 fur ft bra Uarl In glees Huapltelleed per Jay Ind. 4 clteail- Huy 1976 and cal Industry certainly Coop lot e under 500 p|*a Cl Inlcel and career details In. 6 to are 1 wen In a paper by eutoclavea vi*-t4>r Hub let at a) In Arclt. ftetg. exposed to 50-200 ppfl Had. Soc., Hyg. Had. ft hra par Trav. Med. day in 2 5a J Leg. 1977 pagea ruIuc1avaa "iHFiSTT 601-622 exposed to 50-200 ppa in autocjawe roa* Pl 1976- 50 PI** RETIRED 1 rett 1976 02 St 29 09 40 Solvsy Jaoeppa 20 Oft 62 00.10.29 39 II 9 23 10 ft! Yea OB.62-03. 63 01.67 -10.71 * 2 00 ppM fth/day 04.63-12. 66 < 200 Pi** Autoc1eaner Flreaan a luce 5 yri 5 at he 10 71 . Operator 3 yre 9atlia. let sign July ?9i Thoracic pain 0 7.79. Hepatic teste altered 10.79. Positlw echogiaphy 11.79. Ileputectuay 02. ttJ . (Jieautliej apy 1 litoiaal lull ................... letter 12 Nuv 19H4 t run IK lie S1 tiuvu . CANADA 5h<tt I 1 IMPERIAL CtlEmCAL INDUSTRIES PLC LIVER Anglunarcou Ca*e* - (Review Date* l Jan 1986) AU datea Uae UX ayalea DAY ~ MONTH - YEAH WPX/ASL_2 - I.AWGIOCASES. 7 2 1 4 36 7 a 9 10 11 12 1 1 14 15 16 COUNTAY AND REFERENCE NO NAME 00 INITIALS HATE OP HATH COMPANY FACTORY PI AST VC EXPOSURE DATE OP DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO D1 ACNOS IS YEARS OP EXPOSUME DATE OP DEA1II HISTOLOGICAL CvWlHHATlOM ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER II1GHL1CIUS 01 HER COMMENTS CANADA 01 SHAUH UCAH 13.12.11 19*4 1935 41 11 11 02.09.53 Yea Reactor cLeaner Operator Smoker po lyae r 1 aa t Ion 02 06.01.14 1941 1957 43 14 14 21.12.37 Yea Kalcttenauce, operator 1llwrIght, plpef 1ttar Worked overt le Saoker 01 26.06.19 1941 1962 42 21 20 21.01.62 Yea Operator, foreaan Wuiked overtlae Noti-aaokar 04 03.0*.19 1943 1967 48 22 22 21.01.66 Yea Reactor cleaner Operator, foreman, water cooling unit Worked over tlaa Saoker 03 07.03. II 1944 1 966 57 24 05 03.07.66 Yea Reactor cleaner Water cooling unit Worked overt lea Saoker 06 13.12.19 or 09.11.19 1947 1971 51 24 21 10.04. 71 Yea 1946 1972 S3 26 25 24.12.72 Yea Reactor c leaner Reactor cleaner Ha 1ntanance, atllui Iglit WotkeJ overtlae Saoker * Machine altop operator and poly on 11 Worked over tlae Saoker 01 11.03.20 1961 1971 51 12 05 12.06.71 Yaa Reactor c 1 eatier Ho 1 nt etiauc a Machine al*op In plant 25 yral Saoker 09 19.07.21 1946 1974 31 28 2b U4.09. 74 Yea Purnace op. pipe!liter * lilt eildlH.4 Worked over tlac Saoke r Paper by D* P WtLOWtE In Anuala* d'Anatoale petliologlqoe Parla, 1976 Vol 23 No 2 pp!05-ll4 clalaa tlil^'caea had both a hapatoaa and ASL alaultaneoualy. Z $ 9 0 0 VWO CO 3 CANADA Shaat 1 IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Aiigloearcoa* Canes - (Review Dale* 1 Jan 1986) DAT - MONTH - "ftAM All dale* uea UK yte UP*/ASt._2 ~ LAHClUCASES^R 1 1 3 4 56 7 a 9 10 11 12 1) 14 IS 16 COUNTRY Ain reference NO RANK OR INITIALS date or BIRTH COMPANY factory FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS TSARS OP EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER highlights OTHER COMMENTS CANADA 10 16.03.IS 1933 1976 61 21 14 00.04. 77 Yea Reactor c1eeuer Furnace oj. a 1 a!a nance, packaging Ex-aaoker CMA 0 0 6 4 2 9 _______ ________ ________ P*l* 4 CZECHOSLOVAKIA iHfeilAI. CHEMICAL 1MDUSTK fS PIC LIVER Ang loser cows Cases - (Review Dalai k Jen At) Wl/AS\._2 ~ LAHC|UCASK6,9 1 2 2 A 16 1 R 10 11 13 1 ) 14 15 16 COUNTRY AND iirutHCB HO MAKE OR INITIALS BATE OP BIRTH COMPANY PACTOHY FIRST VC EXPOSURE OATS or 01ACHGS1S ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OK DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS CZ ECHOS IJ>* VAK1A 01 26.04.2s Stata Co Novaby 01.07.57 24.11.7) 45 14 14 24.12.73 Yes Au toe 1 eve Cleaner 1 ARC letter of 1-4-62 giving detaila from Prof A David of Centra Ind llygleue end l>cc diseases. 01 04. 01.21 State Co Noveky oi.u.io 27.11.44 17 14 1) 24.11.64 Yes Au toe lave Cleaner IAKC letter of 1 -4-S2 gave ausewhal altered dates fur llila caeu . 1 have accepted the changes a luce tlie dalea c<w frow Prof A David of the Cent re of 1nduet(la 1 Hygiene end Occupetlouel Diseases. Hy dates cute originally fru NIOSIJ. C tt* 006430 rM 1 FRANCS Sheet I IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Angloearcowa Caaee - (Review Oetet 1 Jen BA) UH/ASL2 - LANG IOCASK 5, ID 1 2 1 4 14 7 S n9 10 11 12 14 LI 14 COUNTRY AND timewB NO NAME OR INITIALS DATE OF RIRTH COMPANY FACTORY FIRST VC RIFOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OF DEATH II15T0LUCICAI. CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHEk CAREER HicuLicnrs OTHER COMMENTS FRAMC1 01 H IS.0t.14 r Roue** 00.01.44 IS. 01.47 43 21 19 19.02.47 Yea High Autoclave Dion worker and c leaner 19 yra Ref. Ravler el a 1 Arch. He 1. Prof. 1 10 u* 3 Nov 71 p 171-1 77 01 SIM 03,04.11 PCUR irJgnoud 04.07.39 11.01.71 43 14 12 24.01.71 Tee High 2 yra on Italian Kef. CHIDSH ao tmoaer origin G Rouneioo at Crimea nt) 10 yre on al Nuuvelle polya.r- preaae leetlon aedlca)e 1 Nov 1977 p 711 0) NAV 04.01.10 IP St Foil* 00.00.44 11.01.71 11 29 29 29.04.71 Yen Higb Pulp worker VCM production Ref. Rely at 10 yre ee 14 yra al Arcli. Hal. autocleve Italian POU Prof. 1 17 o' c leaner Shepherd, 6 June 71 Compounding Sawyer, >laeon p SSI-151 3 yra 04 HOR 27.01.IT FOUR Irlgnoud 19.10.49 14.01.74 49 24 24 04.01.74 Yea lllgh Hoitomer product Ion worker 4 yra FVC 111 tret Ion 1 4 yre nOS R 29.GI.3R FOUR Rrlgnoud IB.01,41 11.01.74 34 11 11.01.74 Yea Nigh FuJywurker L >Thoraculooy Ref. P Cuudera II yre 9th Feb 1974 et al Semaliie coatal dee liuapltaua eng 1oaa rcooa 10 Septcehre 7 )Sc lot (graph? 1974 found ASL Prevloualy haJ 1 )llaeeor r Itage b 0*1 B fro* ASL ang Imarcuau 4 Ifclglit A l*o lie pat ec t oay P 11 Ic Itouek 1 el a 1 l-a NouvuJlc Pick.u fcdliulu i1 CMA 006-431 pm* IMPERIAL CHEMICAL INDUSTRIES PlC LIVER Aitilotarcosa Caaea - (Review Data) l Jan I9tt) WTX/ASL_2 - LANC10CASES.1 I 1 1 1 4 56 7 8 ft 10 11 12 13 14 15 16 country aho reference HO NAME OR INITIAL DATE OF RIRTH COMPANY FACTOR! FIRST VC EXPOSURE PATE OF P1AGH0SIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS Or EXPOSURE PATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS FRANCK 06 Fa 14.04.34 rcux Irlgnoud 01.01.38 12.Oft.76 42 IE 11 II.Oft.76 Ye* Hodtitata (Ift5ft-1960) (NIOSH eara 12.09.76) 2 yra f1ItralIon 10-11 yra polyworker and worka lab? rhla nan liad AOL prior to AS. Ann. da Hal. Prof. July * 7 7 p 645 4 6. AOL via found In 1971 five yra before ASL 07 GIR 16.04.27 ip Sit Auhan 01.07.30 Af tar death NIOSH aaya 00.07.76 49 26 22 02.07.76 Yea (NIOSH oo consent) High Plant forenan la polyaerteatlon 1972-6 -Jain act 1 on In St Aubeu Pled of aptIcaaala Snail liver lealou found after autopay Oft ft GL .04.34 Solve? Taveux 23.03.57 03.12.75 42 l* 1ft 30.01.77 Yaa Moderate 6 yra packet A autoclave c 1 nr 14 yra autoclave worker Had bean tuimal worker pravloualy Oft RFX 08.10.14 rr St Foua 10.01.48 26.04.76 63 2ft Eft 25.12.77 Ye* Vary tilth Po 1 yaar- 10 yra In Operated 4.76 194ft-1966 iaatIon eulplturlc for aeauvel ot Laaaa r ope re tor, acid factory, lurtour fru*a Empoeura aut ocleaner ^ etorckeeper 4 liver end Ift66-]ft7b aut oc lave Reueral died eficr a lut alienee eervlcee eecond aurglcal uperat 1un tor blUo broiiLti i el tletu)a Paper by Dr Rety et ol fit An lilvee di- Ha1ade - Profeevlonale Vo 1 40 H,, 6 1979 pagee 741-1. CMA 006-432 IMPERIAL CHEMICAL INDUSTRIES PLC J WFX/aSL 2 - I.ANC 10CASE6112 FBAMCI Shut ) LIVER Angloearcoue Ceeea - (Review Datei I Jau 1906) t 1 2 y A SA 7 S S 10 IL 12 n 14 16 16 CQOlitr AND REFERENCE NO NAME UK INITIALS OATS OP BIRTH COMPANY PACTOMY PI1ST VC E1P0SURE DATE OP DIAGNOSIS ACB AT 01ACNOS1S YEARS OP EXPOSURE TO DIAGNOSIS YEABS Op EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIHATED E1FOSURE LEVEL OCCUPATION OTHER CAHEEB HIGHLIGHTS OTHER COMMENTS Franca 10 VP 24.06.19 BP St Font 00.12.56 10.01. 7S sa 11 l IS.01.12 BP St Font 50.OI.Al 11.01.14 66 21 17 ii i4.04.il PCUIC Brlgnoud 00.03.44 05.05.74 6S 10 ii 14.01.11 Solve? Ta vaux 21.04.4) lA.04.T4 4o 16 ------ n------ HJ 05-04-74 Oiloa CL lata (formerly BP) St Fone nn 00.07.61 52 SR 21 10.01.70 Yea 11 11.11. >4 Yea it 11.04.74 Yea l\ 22.04.74 Yea 16 24.07.41 Yea HLgb High Autoclave cleaner [0 yra In aecliaulcal engineering J nduairy 1946-1966 1941-1946 polyaerleetlon general purpose worker 1946-1972 VCM eyntlteele (HCI A Acetylene) Foreaan (agent d aattrlee) 1972 retIred Died of pulaonar y eabollaa 5 daya after eurgery High Hoitoaer production and polyaer- iNNltoU nue rator Autocleaner 2 yra aa cycle Cigarette 2 yre. Autooperator aeclienlc. 10 yra ae enaaellar In aaoker until 1974. Ill all of 1977 due in 9 jrre, Copolyaere 4 yra aanltary ware aanulacture OeaopUageal var [cm. Surgical Inter ventlun 25.05.79 (r IgliL liejtateel nay) Vary High [941-1975 1975-1979 1941-1975 All lypea of aa 1 lit eitalic a and Jobe on work 1niiltt- aanuf ac t ure cndr 4 aaluleueiic l 975-1979 In VCH Poly Proceee CMA 0 0 6 4 3 3 Pag* I FRANCE SI.est 4 IMPERIAL CHEMICAL I NOUS TRIPS PLC LIVER Angloasrcuae Cases - (Review Datei I Jan 1*66) WPX/ASL_2 - LANClDCASEB.l 3 1 2 3 4 S6 7 6 9 10 11 12 13 11 L3 L6 COUNTRY AMD reference NO NAME OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC tlPOSURE HATE OP DIAGNOSIS AGE AT 0IACN091S YEARS OP EXPOSURE TO D1ACHOS1S YEARS OP EXPOSURE DATE Op DEATH IIISTOI 0G1CAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HICHLICHTS OTHER COMMENTS France IS IIEP 03.01.37 Chios St Pons 07.07.33 IS.06.62 43 27 27 Alive Yes HlgJi-20 yr Aut aclevc 0)1 BlS Model ate cJesusr (formerly 7 yrs 1*33-1962 rp> autoclave operator 1 962-1962 J C Coutssaot Letter of 3 10 1*63 16 G1K 13.07.21 Chios St Poos 17.10.41 03.01.63 61 41 36 03.04.63 Yes 111 Hit-33 yrs Polysierl set- Oilols (Foraerly Hodarsta- ton Process Low - 3 yrs Hen 6P> Maintenance Worker Ha.lth i Safety Agent RetireJ Jan 1*79. J C Contsssot Letters of 3 10 1963 and 23 7 64. 17 HAS 11.02.23 Chios St Pons 17.06.46 03.04.S3 60 34 26 03.04.63 Yss High - Autoclave Other sectors Ret Ired ChUle 23 yrs Cleaner of St Puns 01.01.7* (Formerly 1 *4 6-1971 Factory 1971- J C Contaeaut HP) 1*76 Letter of 3 JO 1961 * *w 9P O0 O0 9 W 3 .... II R 14.07.42 Solvey Tsvsuk 0*. 09.63 21.03.64 42 21 21 27.12.64 21.03.64 Hlgh-12 yrs Au toeJ eve Low - 9 yrs Cleaner 09.01.64 Right Heps Uctuay 05.03. 6424.09.64 r Jieaut lici spy for lung- partlal realaslou. 06.64 - liver i ei'ui reiice. 10.64 - long: BVullI 1 1 Oil Of t lie d Inert)! 9 CRRHAHY Sheet I IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Angloearcoaa Ceaee - (Review Detei 1 Jen 1986) WPK/ASI._2 - LAW; LUCASES, I 4 l 23 n COUNTRY AND REFERENCE NO NAME OR INITIALS OATE OP RUTH 4 COMPANY 14 7 8 9 10 11 12 13 14 FACTORY FIRST VC EXPOSURE OATE OP DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OP DEATH HISTOLOGICAL. CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION 15 OTHER CAREER HIGHLICUTS 16 OTHER COMMENTS GERMANY 01 01 00.00.10 Oynaalt Troladorf 01.10.56 19.09.68 IS 12 12 21.01 .69 Yea (NIOSH) 00.00.11 Dynealt Troladorf 14.10.11 21.09.70 39 13 1 1 14.12. 71 Yea (HlOStt) Polyworker Polyworker 0) 00.00.10 Dynnlt RhaJofel- 09.06.12 00.01.71 43 21 16 10.10.7) Yea (MIOSH) PI 11 In* Reported under dao peatIclde non polyaer- aeroeol cane 1 eel Ion ul tli VC worker* In HIOSH ilt of 11.3.77. Thla of cutiric la etrlctly .correct However 1 wo rule r wlittlier thla aan lied hlgli enpoeure to VCH In hi a can filling ope ret lout 04 00.00.10 Wecker urg- 16.04.17 16.11.74 46 17 11 21.11.74 Yea (N10SH) 200-500 ppa Potyworher 6 1958 wee Cl Inlcel haueoe hut 1.1*6 leaporaiy eut oc1eener Jelella in duihi| 1 yc eu( oc leant r fur 1 yr paper Ity autocleaner Cuke 1 et a 1 Vlicltowe Arch A Path 1976 3 72 p 195-201 > V 0 0 VW3 T t.n P*l* 10 GERMANY fillet 2 IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Angioaercoea Caeea - {Review Oetei 1 Jen 1966) NPX/ASLJ - l-AMCIOCASES.il 1 2 ]A 67 a 9 10 11 12 11 16 IS C0UNT1V AHO RRFEKRNCE NO NAME OR INITIALS BATE OP BIRTH COMPANY PACTORY FIRST VC MANURE BATE OP DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OP EIPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREEN H1CHL1CHrs 16 OTHER C0HHENTS CKRHANV 01 (NIOSH |l t CiM OR) 06 (NIOSH |tvea ee Ceae 01) or OB 00.00.16 Nonehat Frankfurt 02.06.60 10.12.71 16 00.00.12 Louse Ua Uilwt 16.12.62 00.00.71 41 00.00.26 UicUr lurj- hauaan 11.06.14 12.11.71 69 00.00.11 Qynealt Truielorf 19.0 7.16 06.06.71 IS 11 01 16.12.74 Yaa (NIOSH) 1) 12 09.01.71 Yes 21 21 11.11.71 Yes (miosm eaye 12) 20 20 21.12.71 Yea 60 Clieale sa ye 'cbeelelry leboretorlan In Elia Techno logical RevearcH Daparteent (NIOSH aaye eaeJ atant factory cheal at which may be wrong traneletIan) PVC - Manu facture Shift Leader PVC Hanufeccura and all work Inct autoclean Ing 12 yre (1916-66) Foreeen Tech Dev S yre (1967-1971) T Polyworker 7 Confl raed Reported under non-po1yacr~ 1 nation workers In NIOSH llat uf 11.1.77 and l. 7B. 1 don* t think till a la a correct claaelfleet Ion by NIOSH. The aaii aay have bean Involved In VCK po 1 yaer 1 net Ion In pilot plant or In aaln plant. 900 Pa|i I GERMANY Sheet I IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Angloaarcuea Caaea - (Revteu Data: 1 Jan 1986) WFX/ASL_2 - LANG IOCASEB.1 4 1 21 *t COUNTRY AND REFERENCE NO NAME OR INITIALS OATE OF 8IRTH 4 COMPANY i6 7 8 9 10 11 12 1) 14 FACTORY FIRST VC EXPOSURE OATE OF UI AGNUS IS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OP E1POSURE DATE UP DEATU HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION 11 OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS GERMANY 09 00.00.14 cwu Karl 10.02.61 16.06.76 41 11 n 24.01. 78 Yea HIih peeke 11 yra poly- worker incl 1 71 auto- clava cleaning Coni rol roue L yr 10/78 Co uf 1 reed Average empueura f 1 rat 9 yra ISO ppe, ace 1000 ppe. Heat 1 yra av. 71 |i|e. Last. yr av 11 ppe 10 <NIOSII glvaa aa Cat* 11) 00.00.H CWH Harl 01.01.61 00.01.77 40 16 10 07.03.77 Yaa High peak* 10 yra poly- woikar loci 1 71 auto clave cleaning Awe rage expoau re 11 rat 9 yra 110 ppe. ucc 1000 ppe. Last yr av 75 ppe. CWII latter of 21.04.78 11 (NIOSH |lvs aa Caae 10) 00.00.29 Wackar Rurg- 10.10.61 18.06, 77 47 11 11 18.06.77 Yaa High 1 yra auto- hauaau c lava c leatiar 19 yra t 11 tar operator 11 oo.oo.i8 Pyuael t Troladorf 00.00.61 00.10.77 19 16 6 07.10.77 Yaa 1 PVC Manu facture Au t uclava worker for 6 yra CMA 0 0 6 4 3 7 PiB 12 iHftM IAL CHEMICAL INDUSTRIES PLC IVER Aii|Iomtcm Caeea " (Revlaw Date! I Jan I9U) WPX/ASL_J - I.ANGIOCASES,! J 1 COUNTRY AND REFERENCE NO * 2 NAME OR INITIALS 1 ~* DATE OF BERTH COMPANY T rAdfum 4 FIRST VC EXPOSURE J DATE OF DIAGNOSIS a ------------ 5------------- 10 ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS TEARS OF EKHJSURE It DATE OF DEATH 12 HISTOLOC1CAL CONFIRMATION n 14 ESTIMATED EXPOSURE LEVEL OCCUPATION GERMANY n ts.os. a00.00.14 Loru UaltfiM 00.00.40 OB.04. JR 41 IS 14 2 Yea 14 15 (HI05N give* title h Caa* 11) ii o 3: > > Nut an Angloearcoaa In tiia latter or 21 12 611 Mr Frledel aalJ ttila vaa a Flattanepltlialkarilnna Dar SpeJearohra ' (a carclfloar of tlia oesophagus) not attribute abU to VCM 4 not recognised rial disease 00.00.1) Uack.tr Burghauae l).!0.51 0).l0.71 44 ii it 31.10.7* Yea t Autoclava cleaoar and worker. Drier operator. Latar alilft leader 00,00.2) kjfAMl t Troladorf 10.0|.is oi.oa.lt SS n 20 oJ.oi.I* Yea High Autoclave (Laibach A5L and worker till guapected Ha pa locallular 1944. ASL at Carcluoaa Leader and Fab I97S neater laparotoajr) IS OTHER CAREER highlights li OTHER COMMENTS F W Heat letter ul 10th Juoe It00 eucloalug data f rua Hr U P FrUdel of RG Cheat le F U Real letter of 10tU June 1900 entlosing deta iron H P Frieda! of BG Cheaila wlthdrawlng t Ula raaa Angloaarcona conf1raed 09/79. Suae detail of tbta 4 eleo caeee 9 , 1), IS, 14 4 17 given In NRIf Report lot 1 978 Angloaarccwaa cuufIreed, full detalla of Itloeee iiluce Mercli 1973 given lo NHU Hed Inep Rep fur I97fl. Ill f ferciit Julelte g 1 veil In VC Aw am' lei ed U1 lumc by 1 e tbecli end Hdituller <i9BI ) |i7t. p age n SERHAtfY gkaet i IMPERIAL C UKHI LAI. NDUSTR1ES PLC LIVER Aogluearcooa Causa - (Review Dacei I Jan 1986) WFA /ASL_2 - l.ANCIUCASEB.lft a' 2 3 A 56 7 9 10 II 13 1 3 14 12 16 COUNTRY AND uriiencE HO NAME OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS GERMANY 17 (NIOSH Rives as Csss 15) it 19 *4 11 13 00.00.17 Dynes!C TroJedorf 01.11.61 14.OB.7ft 41 16 11 2ft.Oft.7ft Yes Hlgli Autoclave No Angiosarcoea worker confIrsed. Annual report of Lhe North Rhine Webtphal la Medical Loapecturete lor 1978 pages 147-177 gives full dels!1 a Vinyl chlorIde d1aeaaa d1 ornosed 02-02-73. Oeaupliegea 1 varices. Radiologically confirmed rru osteolyala. 00.00.12 Bosehat Cendorf 00.MI.i5 25.12.)* u ii it 3l.il.ft Yea Autoclave Worker 6o.Ao.j5 Dynastt Troladorf ii.io.il 00.08.79 ll. .snIS ii 02 Yea High Autoclave Heteatealng Worker ASL Dr Beaclie letter of 11-04-62 to Dr tt C P Adeev is557505" Dynsailt TroJedorf 14.02.11 "557505 19 12 19.l0.SO Yea High Autocleve Haenangto Murker End0the 11oaa of 11 ver with Dr Beache letter of i 1-04-62 to Dr W G V AJjae oo.oo.n DynaaIt Troladorf 01.01.02 00.09.79 a 18 12 is.oA.ao Taa High Autoclave pronounced llaeaaoglo Wo 1ker and c linlcal Endottiu 1 lou worked In 1 Ivcr of liver wills drying aliop .yatua.) Dr Re ache letter of 1 3-04-62 to Ur W G F Adaub 00.00.21 Dynes!t TroiaJorf I5.10.il 3B.OB.ftO 29 19 11 06.l3.ftl Yaa High Autoclave Qtargchend, Dr Bcarlm He taetaalng Worker soLea que ul 1 y letter of ASL Fu reaan 1 3 04-62 to Dt U G Y A.i.imu CMA 0 0 6 4 3 9 Page 14 GERMANY , Sheet t IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Anglouarcoaa Cases ( Raw Data; 1 Jan 1966) W1`X/ASL_2 - LANG LUCASES, I 9 Jl COUNTRY AND HFEUKCB HO 2 NAME OR INITIALS 1 DATE OF RIRTU 4 COMPANY CIIHAHV n ILF 00.00*27 Wacker 1 FACTORY BurgItauaaa 67 FIRST VC EXPOSURE DATE OF DIAGNOSIS 1955 26.03.79 6 AGE AT DIAGNOSIS 52 9 YEARS Of EXPOSURE TO DIAGNOSIS 24 10 11 YEARS Of EXPOSURE DATE OP DEATH 21 29.09.6i 12 1 ) 14 15 HISTOLOG ICAI. CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPA no* OTHER CAREER HIGHLIGHTS Yea High Chselstry <300 pp-) Worker - 16 OTHER COMMENTS Prof CedigM atataa FrleJel leltei 19.04.65 24 HL 00.00.26 Uacker Burg- 1966 11.10*62 54 1) 12 2 6.05*6) Yea mi ah Autoclave haueen (*300 p(aa) Claener 2) E.flch 00.00.2) Vacker Burg- mo hauaae 26.09.61 56 21 u 14.01.6) Yee High Polyclave Worker and Autoclave Cleaner Prof Kiler (Munich) letter 22.OB. 63. Frledel letter 19.04.65 Prof Selaalr (Hunlek) Frledel laltei 19.04.65 16 EM 00.00.22 CWH Harl 1953 14.06.76 54 22 22 22.11.62 Yea High Polyworker Ui ronlc Hepat It 1 a (1 elbach). Frladel let let 19.04.65 27 UR 00.00.21 Dynaelt Troladorf 1955 16.01.61 55 26 16 02.0). M Yea High Aia toe 1 ave Cleaner till 1972 J a 1 bach. Pr 1 eile 1 letter 19.04.65 CMA FeRd 13 ITALY IMPERIAL CNKHICAL INDUSTRIES FLC LIVER Hiiglonrcou Caul " (lovleu Data; I Jan 1916) WPl/ASLj - LANCIUCASES, 1 l 3 4 S4 7 a 9 10 11 12 13 14 15 14 COUNTRY AHO iireiwci NO KAHt OR INITIALS DATE OF aiRTH ITAI-T 01 (0* N10SH ewpplawantery lilt) I.G IS.04,34 COMPANY FANSAC FACTORY HI r* VanJc* FIRST VC EXPOSURE 00.00.43 DATS or DIAGNOSIS 19.04.71 ACS AT DIAGNOSIS 34 YEARS OF EXPOSURE TO DIAGNOSIS 04 YEARS OF OATR OF tirosut DEATH 03 14.04.71 HISTOLOGICAL CONFIRMATION IYhb ESTiMATEO EXPOSURE LEVEL OCCUPATION FVC Bag extruder OTHER CAREER HIGHLIGHTS OTHER COMMENTS Prlaary tuaeur way liavfe been pe rIcardluw. Not Iimit gaiutoua with otliar caaaa. a a* 01 SR 13.11.29 Moatadlaun Forto 00.00.S? 13.12.72 41 IS 04 17.11.72 Y** Marghara Folyworkar a a* 0) VO 14.03.10 Salary Farrar* 00.01.S3 10.01.IS 5S n 11 10.0?.IS Yaa nigh Aulocleaucr 1972-S did S yra (19SJ- a varlaty of 41) Autuclav t Joba oparator Includ1ng 12 yra (1941- FVC packing. aa 04 FI 20.07.3? AN1C Ravenna 00.04.39 00,01.01 41 21 11 30.03.01 Yea 12 yra - 1 yr - Never c1eaned Vary High 3 yra " Honuaier operator autoclave*. See paper by CHIAPPINO el aa Non~ awoke r Hedlu* 20 yra - el Hed Lavuro Coneuwed 4 yra - Autoclave operator 4 Vo 1 4 (1907) pp 555-541 little a 1 coltol. No Low other Jut lee AOL. In auapena- * Ioq pulywer- 1aatIon. Area luftaru In aawe Dept Inca 1973. OS C Oancaln 19.03.37 FA NSAC HI r* 00,00.47 07.01.S3 Vaaica 44 14 0 04.04. S3 Yaa Hedluw-1 Nigh Rag extruder 1947-1975 Cowwerclal Dept 19 7419 S3 S PagllaL-mtg* telex ut 2 Atig 1961 * Ska Haltanl Med dl Lavoro 6i p44S, 1974. Further detail* In letter froa Dr Hunteaano of IARC on April lat 1982. ** Alsu ae Hal ton I and Rondlnelle in Acta Oncologic* Vo I 1 19(113 page* IS - 19, Ifr tr 9 0 0 VWD Fega 16 Japan IMPERIAL CHEMICAL [ NIK'S TRIES PLC LfVER AngloiarcoH Cia< - (Review Dalai I Jan 1966) WEI /AiL_2 - LANGIOCA3ES.21 1 2 3 A iA 7 6 9 to n 12 11 14 15 16 COUNTfV AND REFERENCE NO NAME OR INITIALS DATE OF RJ Itll COMPANY FACTORV first vc EXPOSURE HATE OK DIAGNOSIS AGE At DIAGNOSIS TEAKS OK EXPOSURE TO DIAGNOSIS TEAKS Or EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIHATED EXPOSURE LEVEL occupation OTHER CAREER HIGHLIGHTS OTHER COMMENTS JAPAN aa a 01 TonoJI 01.06.22 Kltaul Naftoy* N.U. 24.10.75 51 12 1 3 24.10.75 Vaa PVC Aaaoc . 11 jrra auto- Mori Toalau aajra not c lave (no COBMIlt known. cleaner ky Jap PVC * Japan 1964 - Aaaoc) TJ aaa aaalgned to Indicated different on 25.10. 75 work elnce axpuauiaa bad 1)1 often at bealtU 3000 ppa up to 1974 Jajan Tinea 25.10.75 4 Japanese PVC Aaaoc latter of 31.03.76 01 SO 02.06* 39 00.11.56 10.06.76 37 17 n 10.06.76 i Hot known In polyner- 1 #atIon work 1ncludlng eutoc1ave cleaning Japaueee PVC Aaaoclatluu letter of 11.03.76 * In 111* latNr of 1*1 April 1962, Dr Hontaaana of IARC aaya ij>ai)ua Hlnlatry of Labour |laa Dm* of Jla|aaii - 21-ON-74 A| of lla|ooaia - 52 Tear# of aspoaura - 22 CMft 0 0 6 4 4 2 17 NORWAY IMPERIAL CHEMICAL INDUSTRIES PLC LIVEN Angioaercuaa Casea - (Review Date: ] Jen I9B6) WFX / ASl._2 - LANC1GCASES,,22 ft1 2 3 4 S *. 1 9 10 n L 2 13 14 15 C0UN7IY AND RIKIBNCB HO NAME OR INITIALS DATE OF 1IRTH COMPANY FACTORY first vc EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER highlights 16 OTHER COMMENTS NORWAY 01 AN 23.17.M Norak lleroya 00.03.SO 21.12.71 56 22 n 04.01.72 Yea High Foreaan 4 Hydro Autoclave Confirmed by Dr Till la' Kvanaan of Ml. Ac APHE HLr of 9 June 1978 Mr P RanRiiaa Mated that AH bad been a caber of a eiad-up leva. VCH A FVC were aade In aeee bullJlo|< Ttie VCH wa* aade froa acetyl tiw CMA 0 0 6 4 4 3 rage it SUBORN IMPERIAL CHEMICAL INDUSTRIES PLC I IVER Jui|li)<rcM Cam - (Review Dit<t I Jen 1966) WFX/ASL_2 - L.ANCIOCASES.2 3 ft1 2 3 4 J 6 7 9 10 n 12 13 14 11 16 COUNTRY AW REPEREHCB NO KAMI 00 INITIALS DATE OP BIRTH COMPANY PACTORT PIRST VC EXPOSURE OATE OP DIAGNOSIS ACE AT DIAGNOSIS TEARS Of EXPOSURE TO DIAGNOSIS TEARS OP EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHCt CAREER HIGHLIGHTS OTHER COMMENTS SWEDEN a 01 NU 31.04,2? fcesanord Sunday*)! 14.06.11 20.10.70 43 19 Ift 20. 10.70 Tee Polyuurkar 6 02 RL 2Ml.ll Eeuanord Sunday*II 00.01.41 00.08. 72 61 27 27 16.0ft. 71 Tee High VCM produc t Iuq 03 HE 10.06.10 Renacurd Sund avail 00.01.47 16.03.76 61 19 21 19.03. 76 Yae ii laic Polymarker Hr Sjoelin'a 1 ftletter of March 197ft cunflraa BL wee a aonoacr heavl Ijr eapoaed. probably even aoia eo than a norael reactor cleaner 04 AL 16.II.14 Kaaenord Suitdavell 00.00.46 12.01.77 62 31 31 12.01.77 Tee High 1946-1918 polynerlaaf ton worker (12 yre) 6 191ft1977 foreman 09 y>w> OS 12.01.19 Keaenord Sundeval1 11.01.64 22. 11.80 61 16 16 22.11.60 Tea High - 1964-1970 6 Teara centrifuge Low - operator 10 Tears 1970-J96U drier operator In flrer 12 yre of eaployaent had been heavily eapoaed. In 1974, liver abnormal11 y end oecroe la dlagnoeed. Date cuitf J rued lu Dr 0 By fen letter L6.ft.77 to CLP 1C Letter uf 2nd Now LVftJ frou Dr David Ryien W V 9 0 0 VW3 * In Hie Idler of let April HB2, Dr ttonteeano of lAJtC ura la Sweden1* National luard of OS He*lib give* 20-02-70 aa data of diagnosis for Case 01 end I1-0W2 for C**a tU 19 JK Sliaat I IMPERIAL CHEMICAL INDUSTRIES PI C LIVER Angloaartowa Caeca * (Review Data: 1 Jun 198b) UPX/AS1._2 - LAMCIOCASES.2 4 1 2 ] 4 56 1 8 9 10 11 12 I 3 14 ]5 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OR RIRTH COMPANY riCTMV FIRST VC EXFOSORE DATE OF UlACHOS IS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXrOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHEt CAREER HICI1L1GIITS OTHER COMMENTS UK 01 UJ 20.04.01 1C1 HlUhMM 04.M.1* 03.12.72 71 28 22 01.12.72 Yea 500 pji 1944-7 VCH (Fun 6 (Foa 4 194 7-8 Drier Collier Col 1 iar 1948-61 paper aaye paper Autoclave 23.12. 72) aaya oparator 21.12. 72) 1961-66 Drier Lee and Harry Lancer 29-06074 jiagea 1)16-8 02 0) &JII 04 JS1 02.06.17 IP t 22.06.20 ICI liiry 00.02.66 00.12.74 37 Htllhouee 26,04.54 00.06.79 59 Dubious fabrics!lun caaa 09 1.5 24.12. 74 Yaa High Autoclave cleaner Eapoaura Halted to 2.66 - 9.69 25 IS 12.10.79 Yea ttadliaa- 54-5 Pre-war fleh Mill 9*111 HR Plant packer 55-6 vehicle Drier Plant weJ ntenance 56-58 iiii-si Autoclava Hah packer woe ke r 38-61 Chargehand Drier Plant 61-72 Fore* in C 2/J Plant ^^900 VWO _____________ j----- Paga 30 UK Shaat 2 1 13 OQUtfTRY AND REFERENCE HO UK OS NAME OR INITIALS JK DAT! OP RIRTH 10.0), 14 oi CEP Hil AT RCR H. M.io 4 CO+fPAKY BP BP BP FACTORY Barry Barry Barry IMPERIAL CHEMICAL NUUSTAIES PLC LIVER AngJoearcooa Case* - (Review Data* I Jan 1966) 14 ----------- ----------- s 9 10 u First vc EXPOSURE OATE OP DIACHOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OP DEATH OB. 01. SI 00.10. AS 26 21 19.11. 19 liil d4.di.Ao H7* it 12 09.01.10 rsn 00.00.10 0 iT i.i I3.0t.10 12 HISTOLOGICAL CONFIRMATION IJFX/ASL 2 - LAHCIOCASES.2 5 ii li ESTIMATED EXPOSURE J EVEL OCCUPA riON 1951-52 Folycleaner 1952-55 Late* 1955-60 Polyfloor 1960-64 Poly Charge ha ml 1964-70 Charging operator 1970-72 Drier operator 7 yra Poly Floor Operator 5 yra Greener on Potv Floor folycleaner 1965-5 Recovery 1965-1971 IS OTHER CAREER HIGHLIGHTS 16 OTHER CUHHENTS ii UTH 0A.O3.l4 BP Barry 13.09.30 2T.1i.il 57 ii i3.ii.ii mo-mi 500 pp* 19 AS-IS 74 200 pp* 1950-51 Autoclave Motor Mechanic operator 1946-1950 1951-1957 Qiargepau autoclave Operator on Acetylene P roduc tIon bill lAtng Plant 1957-1974 Shift enpervlaur Autoclave building - Haver c1eaned lutuc Uvea but eupervlaor'a Job ant a lied entering autoclavea to 1 impel t the* CMA 0 0 6 4 4 ri ii MK Ihiet 1 imperial chemical industries plc LIVER Angloearcoae Caaee - (Review Du let 1 Jan I9A6) 1 2 i --i r"3--: i -----------j----------- i -------------$------------- 10 11 ODUNTBY AND arniNCK iio UK 09 NAH1 01 iNiruu tier DATI OP KI1TH 02.0S.2i COMPANY IP FACTORY mat vc exposure DATE OP DIAGNOSIS Barry IS.02.SO 01.01.15 ACE AT DIAGNOSIS SB TEARS OP EXPOSURE TO DIAGNOSIS YEABS OP EXPOSURE DATE OF DEATH 51 29 24.02.ftl 12 HISTOLOGICAL COMF1CHAT ION Tee WPX/ASL 2 - iJLNC I0CASES, 26 l\ n li ESTIMATED E IPOS URA LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS Med 1 ua Polyworker t yaara oo Acrylonltr1 la Realn Plant. Alao prior to 1950. 4 yeara RAP aalutenance. 5 yeara aocor car palutahop. 2 yeara in Craving Dock. 16 OTHER COMMENTS IQ GJT 04.04.4? IP Baccy 27.04.66 01 05 04 17 IS 4.2 L6.05.ft4 Yaa lll|h - II PoLycleaner Heavy guude Inforaatlou a on Ilia (500 1966-67. vehicle driver given !u ftpa ). Low- Spreyerdrlar until final latter 1B aouthe Li||r 1967- 11Inea. 1 A. 06. 64 fro* <50 ppa). 6ft. Blow Dr D H J Medina - down WJUlaaa 21 anntlia airlpper <200 ,,*) operator 1961-70. II ctr oa.os.it BP tarry 19.12.AS 02.06.IS 57 It 16 02.04.15 Yea Ul|h Polycleaner 1965 -69 l965-6ft. Had 69-79 Service Low 79-B2 opere tor 6ft-69. Poly Operator 69-79. Leading Hand 79-62. 12 JT 24.01.11 ICI HI llliouee 16.09.57 05.06.15 4S 2ft 2ft Yaa Lu 1957-19 Spara aen, High 59-74 Legging Low 74-ft! f loor 1957-59. Autoclave Operator 1959-ft! Letter of 04.06.65 Dr Paul Sol tli and laliar of 04.06. B5 Or 0 H D Eveua Oeaopbegaal heuaorihage Jue to oaeuphageal varlcaa due to Ang1oaa rcoaa of liver Let tar 2 6.06.65 Dr F 1 Lee -9a CMA 0064-47 Pm* USA Sheet I IMPERIAL CHEMICAL INDUSTRIES PLC I I VEK Angloearcona Cases - (Sevlew Datet I Jen 1956) UK ayeteu of dates DAK - MONTH - KKAK WP*/ASL_2 - LAf4ClOCASES.1T i 2 1 4 14 7 6 9 10 11 12 11 14 11 16 COUNTIt AW) ItmtHCE NO NAME ON INITIALS DATE ON HATH COMPANY PACTOKY Fiasr vc iipoaoaa DATE OP DIAGNOSIS ACE AT DIAGNOSIS YEAHS OP EXPOSUKE TO DIAGNOSIS KEANS OP EIPGSUNE DATE OP DEATH HISTOLOGICAL C0NP1HJIATIOH ESTIMATED EXPOSUKE LEVEL OCCUPATION OTNES CAKEEN HIGHLIGHTS OTJtES COMMENTS USA 01 Ear) 17.10.13 arc Louis 09.12.4* 01.01* 71 49 24 21 03.0).71 Yes Parks ville Put Cleaner (Slock Jaaa 1974) p 11 Dietary given Bull|ng Stout In Airnale NY Art ACAD SCIENCES Kef 1 NY Acad Vol 129 (1979) of Sc Syap page 190 In 1974 Paper by Also Slock S B Cot tine of Jaaa 1.7. 74 0SI1A , Ji 01 I9.0fl.il arc Loute- ll.U.ll 00.01.70 17 14 11 27.09. 71 Yaa vllla (NIOSH aaya 26.09.71 ) 01 Edward 15.01.11 ere Louis 2 a. i i.4i 19.12*7) 16 26 25 19.12*7) Yaa Dinwiddle ville 04 11.01.24 arc Louis 04,07.12 19.04.47 41 l) 11 07*01*65 Yaa ville Pot Cleaner (Cf Slock) Pot Cleaner (cr Bloch) LouJevl1le Courier Journa1 02 -09-60 Pot Cleaner (Cf 61uck) Kef 1 Also Slock JAHA 1. 7.74 P 5' Be f 1 Aleo Slock Nef 1 Aleo Block OS 21.01.11 arc Loule- 19.04.44 09.04.44 12 20 20 09.04.64 Yae vl lie 04 Is? n. n.2i arc Louis 17.01.62 00.02. 74 41 12 12 24.07.71 Yas Austin ville Jo ueef Pot Cleaner (Cf Slock) US Air Porce Pot Cleaner (Cf 6 lock) Kef 1 Aleo Slock Kef l t Louisville Tines 2). 7. 71 Retired April 1974 Aleu Slock 07 Otar lea 01.01.22 ucc S Charle- 27.06.44 00.00.66 41 24 17 21.01.66 Yaa T Seart etoa Kef 1 CMA 0 0 6 4 4 8 oa 04.01.20 Goodyear Niagara 07.10,46 00.06.61 41 11 11 2 9.06.61 Yes Kef 1 page IMPERIAL CHEMICAL INDUSTRIES PLC USA Shoot I I LIVER Angloaurcoae Coooa ~ (Review Dote; l Jon I9S6) '2 3 A sA 7 S 9 10 11 UX eyatee of date# day - Horrm - year UPX/ASI. 2 - I ANClOCASES,29 12 11 IA IS 16 COUNTRY AND REFERENCE HO NAME OR INITIALS OATE OF RIRTtt COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EIPOSURE TO DIAGNOSIS TEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION EST1MATED EXPOSURE LEVEL OCCUPATION OTHER CAREEN HIGHLIGHTS OTHER COMMENTS USA 0 Rayaond OR.II.11 RFC Louie** 29.03.AS 01.01. 7A A1 29 2A ll.01.7S Tea 2000 ||M Cottle** villa Finger! Ref 1 haa wrong figure# ra ftrei oepoauro. l.oulavllla Tinea 29.10.74, 12.1.75, 10.1.76 10 16.09.13 Goodyear Niagara 11.Ob.SI OO.OS.6S SS 17 17 10.OS.6ft Tea II I?.OS.09 Goodyear HIagaro IA.10.At 00.01.70 61 - 21 21 16.01. 70 Yea Ref 1 Ref 1 11 Frenclo A 17.11.19 FI roetono Fottetowo 13.07,49 02.OS.69 SO 20 19 02.OS.69 Tea High 10 yra 10 yra ea Utility A Ref 1 let tei IlClOM Fa reactor op. Service op. of 26 Aprl1 (not cleaner Bagger 1979 Iron - eaparate Dryer op. Rueeell A Park crew cleaned Stripping op. to J T Saauell eutocloveo) 1 yra prior of HCA eervlco In tyre plant s 13 Richard 01.12.21 11CC 9 Cherle- 11.12.A1 00.OS,7A S2 12 26 07.0A.7A Yea 2000 ppa Edward otun Clendonlo Char leaton Dally Mel 1 21.7. 75 14 Hover diagnoaed a* augloearcoaa of llvar. InfujriaatIon given In letter 22 Hay 19M fro* J A Salg. CMA 0 0 6 4 4 9 IS Accoimlaot i ASL ~ No v l .Ionic of VCH e tpo aura. 24 IIU IMPERIAL CHEMICAL INDUSTRIES Pl.C LIVER Angloearco** Caaee - (Review Datei l Jan 1984) UK Syaten of date* day - month - year UPE/ASL_2 - I.AMC IQCASES,2 9 . 1 i 4 9- 4 1 a 9 10 11 12 13 14 19 lb COUNTRY A HO REFERENCE HO NAME OR INITIALS DATE or Riimi COMPANY FACTOHV FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION CSTIHATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS IISA 14 Janaa 04.11.22 BPC Howard Louievilla 08.09.90 00.00.49 41 19 04 27.03.49 Yea 1991-4 VCH poljwerlaatlon I'roa 1994 Table 4 In onward a in Uainner Amy and other Teatlaeuy to ervlc*. US Senate 44-90 Amy Confirmed la H N Johuaon Ur 07.oa. ?a l? Faaraabooo 04.09.31 RFC Louievilla 23.04.99 11.10. 24 43 19 18 Clierl le 22.04.28 RFC Arthur Avon Lake 19.09.94 00.00. 29 44 21 Yea 19 14.10.80 on 11.10.74 but no poae-aortaa 14.10.80 13 02.11.79 Yaa 13 yia Navy autocleanar S yra on Eetol Tyre Store plaaticieer 4 Cerboeet operation Or H K Jolwiaou latter of 24.2.81 coir fliwed death 4 yeara after Jiajcnnale Ikmfiraed In N M Johneon Ur 07.08.74 AJ ao Rol1ln| Stone *. 1 9.01.74 19 VI rail 00.00.19 ucc R Charle- 00.00.43 19.04.29 40 32 32 04.04. 74 Yea 2000 ppa Chrlat Ian aton Willlaaeport Sun Carat t a 21 June 1979 Ctia rl eat on Daily Hall 21.7.79 20 11.08.12 Goodyear ttlaRara 00.00.99 30.01.14 9ft 21 IS 30.01.74 Yaa NlGSIl latter of 29. 10.79 21 Cheater 02.09.09 UCC S Charle- OU.12.44 titi/ a 42 30 22 02.01.77 Yea HlaUi a ton 28 yia with UCC at SC Ret IreJ Hewe rcUaeu 21.2.77 P 9 0 0 VW3 tn *5 USA Shaat 4 1 1 ------------- --jr-*--* JA 3A IMPERIAL CHtM[CAL INDUSTRIES PLC LIVER Angloaarcoaa Caaa ~ (luvlav Date; I Jan 19S6) 1a 9 10 11 UK ayatea of dataa OAT - MONTH - YEAR WP*/ASL_2 - LAMUluCASES t30 12 13 14 15 16 COUNTRY AND REFERSNCI NO NAME OR INITIALS DATE 0? E1RTN COKPANY FACTORY FIRST VC EXPOSURE DATE OP DIAGNOSIS ACE AT DtACNOSIS YEARS Of EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CARRES HIGHLIGHTS OTHER COMMENTS USA 22 ii U "(HI 02.10.13 SEC Loul- 11.02.41 00.01.76 52 29 2S 04.12.76 Yaa villa Charlaa Edward Moor a oo.oo.n 177507" Great Aaarlcan Cholcal Coapanv UCC FI tchNtri OS.OS.3S Haaa. S Charlaat on mr oi.oi.7i 17.OS.77 JO i6 ii 14 501771" lea H 141 i7.05.7J CtiolanRto- (NIOSH aarcoaa aaya 24) (R KaaJnekl 26/2/79) j Raaoiral froa rejJ atar conf raad In R J aalnakl lat ar at 3 Movetaker I960 ______ ! __________ l ________ ________ _________ Loulwl 1 la Tlaea 26.1.76 aald lie wee die IDiU AS vlctla at Sella Lane of wliua S had died by 26.1.76 In hla letter of 16.09.SI Or H M Jolmaon eonflrax thla la die cave described by Dannalier Taabnrro 6 Yaa In Feb I9B0 Aa J Medic Jim* Vol 70 i>260 He dime to hl|b for 24 yra 1941-63 non- lit Mi ... N H Wheelar aolvent off and on letter of vinyl realn labourer unit and 1*14-41 1S.S.77 to J Stafford dlaparalon Have been jtlvea delal lx vinyl realm ex^oited aa Roaa Xaalnakl unit flrat rvactar aa fitter cleaner helper, tbe 1943 beraae shift Lift fitter utility aan 1946 bee vac letter of 26/2/79 R KaalnakJ (6 Nov I960) euftgext* that vliift utility Mil 26.04.65 NIOSIt will r.txlu an ref later aliicc eaptuyaent via ttiix neupkaxa tctaluated ay be a avoc1~ auJ u l di ASI . 1 N Wheeler letter of 20/2/79 and Raau Kaaf uak1 letter* of 26/2/79 and 5/1 1 /SO CMA 0 0 6 4 51 r>| 24 USA filftt ) IMPERIAL CHEMICAL HIIUSTRIES PLC LIVED 4i|loircou Caw - (Itvlav Datei I Jan 1984) UK eyele* of date* DAY - MONTH - TEAR UPX/AbL_2 - LANG INCASES,11 COUNTRY AMD RRFRKHCC NO USA 2 NAME 08 INITIALS 2 DATS or BIRTII 24 Join Sorry 07.0?.n A COMPANY src fArtttur Louis** vlHo i. mst vc EXPOSURE 0),10.47 17 J L 11.05.16 ucc Forreet B Charle- oi.o).4i *tO* ift n UVN ii.ol.il ucc li.io.o) ucc S Charli- oa.oa.tt ton 3 Charle 00.0l.l2 ston ior.ir Tmmco riouiosto ll.0i.il Chealcele ii 01.11.25 UCC S Charla li.oi.U st cut 7 DATE or DIAGNOSIS 00.00.77 {up to 2 year* after death) 5o.ii.ia 05.11.51 oo.65.fo io.ii.to oi.oi.ai s ACE AT DIAGNOSIS 22 (death) 62 61 Jl 4i ' 4) * 10 11 TEARS Or EXPOSURE TO DIAGNOSIS TEARS OP exposure DATE Or DEATH IB (death) 18 II.01.75 i) 20 ii.ii.5i (NIOSH aye 27 end C Daily Hall IS) 51 55 05.ii.5a 3i it 6i.6i'.to |5 ---- T5--------- 3o.il.ao is l3 02.04.32 12 HISTOLOCICAL CONFIRMATION 11 ESTIMATED EXPOSURE LEVEL 14 OCCUPAITUH IS OTHER CAREEN HIGHLIGHTS lb OTHER CONNERrS Tee Tee Tee Tee Yea Tea Expoaed In Varloua Jobe eoae degree In PVC to 22 plenta true R KaaJnakl letter of 26/2/79 and chualcale cold rooa to Prof. Taaburro but aaln empoeure peete recovery to letter of 9/1/79 uae to VCHj PTC charging probably operator to high peate charging. Ill Auguat 1965. Te raj fiuted e*P layueiit High Jan 1966 Operator to 10.10.76 Exposure In bulk and R H Uheeler 1tr of 4 Jau d tape re ion I'VC 1979 and aanufacturc Charleston Dally Hall 10.11.78 and R Kualtiakl 26/2/79 R EaafneVI letter of 6/4/79 1 Kaalnakl Letter* of I9tb June I9BO 6 5th Nov 1980 6 - Unknown Maintenance 9 - Hlnlaal Mechanic 6 yra El*ewhere IK yra Roller liuuee Operator High (lut 9 yra Ctiealcal free 1959 to Dr Decoy not aa Itlgb Operator In 1976 Allphet U loiter aa reactor charge Chenlcale 16. 10.81 and cleaner reactor operator aud M N Uheeker would expur lance) fiua July 1976 latter of to data 9.11.8j. Worked ae Fu i auo Aleo Nr Decay 1ubourer i roar Al Ipliat 1c Cheat cak letter of 07.05.85 re June 1941 <Jperut loo dute of death. to May 1946 anal nay Have cleaned reactor* In that llue V9 0 0 vwo fug# 27 USA ShMt 4 1 ---------------23 4 IMPERIAL CHEMICAL N0USTRIR9 LIMITED LIVER Angloaarcoaa Ceaee - (Review Date] 1 Jan 1996) 34 9 9 to II UK eyatua of dele* DAV - HUNT It - YEAR UPU/ASI._2 - I.ANCI0CASES,)2 12 13 14 13 14 country ahu REFERENCE HO HARK OS INITIALS DATE OP B1BTH US 32 C U Giroux 22-02-09 coup** fACVMLY FIRST VC I1NSUU Hohmio l r Him 1 15-10-51 date op DIAGNOSIS 00-0 7-79 US 33 S Ferguaon 09-10-27 Jar PC Loutxvllli 09-09-34 11-05-92 us n Hr Byrua 29-01-34 PC LoulavllJ 1933 03-11-92 US 33 US 34 09-03-12 ucc S CberU- 23-07-44 itoa 18-07-93 IHHi Hie General Asblab Tire end Ule Rubber Ci> U-06-56 2I-G9-9) ACE AT DIAGNOSIS 71 34 49 71 30 YEARS OP EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS 29 14 17-03-90 An eutopajr The death 1940-1931 (In PVC autoclave eree) wee done end leeaillite ceuee of death Riven car11 fleet* Varloue Jobe 9*ve In potyaer Hr Giroux4 aanufaclure ueuel RUTVAR ee occupation LUSTREE `Aug 1 nee rcoea a* kettle 1931-1944 operator Varloue Jobe In In and 'cbealcala round PVC JnJuatry * autoclavee 1944-1973 Varloue clerical job* In PVC polyaer1ee 11 an fecility/ Retired 01-01-7). Inforaatlon Riven In letter uf 24 February 1997 froa Dr Natter C Re nice of Houaauto Springfield to Or A Nunn uf Homnmtu Eu rope. 29 29 Alive Ye* Multiple Jobe IncludIng Poly Operator t Polvcleaner. 1`cof Taabucco letter of 12 Aug 1992 t Dr H N Johueon letter of 29 Feb 199). 27 10 04.09.93 Ye* Paly Operator + Autucleva Cleaner 1955-45. 1945 left RIG to beioae a Clurjfyaan. Ur H N Julio no ii letter uf ) Nuv 1992, 29 Feb 199) and 9 Aug 1994. 39 14 19-07-93 ** High froa 1944 to 1933. Hedlua Iron 1933-1939 Or Uacey letter of 5 Sept 19BJ . 27 27 Alive Ye* Moderate 1934-56 labourer 1954-37 prod helper 195 7-70 operator 1970-73 electrician 1973-prcaent operator R W l.NUitdrle letter uf 12 Sapt 1993; putceJ at aedIt at May 198). Teal lug L LHWiOIIL ed Hay 199) CMA 0 0 6 4 5 3 r*s+ a* USA 8Wt 7 IMPERIAL CHEMICAL INDUSTRIES LIMITED LIVER An|loarco* Cm< - < Review Dele; l Jen 1986) UK lyiiH of ii*t* DAY - MONTH - YEA It WFA/ASL_2 - LAMG LOCASES ,33 1 1 3 A JA 7 a 9 10 11 12 13 14 15 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATA OF BIRTH COMPANY FACTORY FIRST VC UFOSDRS DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS Or EXPOSURE TO diagnosis YEARS OF EXPOSURE DATE jOF DEATH HISTOLOCICAL CON MR NATION ESTIMATED EXPOSURE LEVEL 0CCUPA1JUM OTHER CAREER HIGHLIGHTS OTHER COHHENtS US IT Hr J 19 OS 29 RFC Loula- 1433 06 08 64 34 31 22 06.OB. 64 Yea tilth Worked Feytoe vllle regularly In PVC area. In the aarly day* wae a reactor cleaner 1953-75. Inforeatlon glvae In letter 09.08.64 free Dr H N Johueon US 3* JU it oe 2i Ale Product* Calvert City 00.01.*3 19,01. DA 61 20 20 26,10. 63 Yea HI ftli Noreel prir- 1963-1982 sreeelou froe helper to aeeJor operator, cleaned raactore, tripping apil recovery area* aa well a# charging operator. Throeho cylopenla and leukopenia Inca 1976. Culd trealaent for arthrltle 1976. Undat Or*a care about 6 aunt be before death, had paeeed etandard physical e*ua~ InatIon 3 eonthe earller. J Barr lectern of 22. 10.64 6 73/01/65. CMA 0 0 6 4 5 4 29 (UCOSUVU IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Angloaarcoaa Caaaa - (Review Data: I Jan 1966) WPX/ASL_2 - LAHC[OCASES4lA ) 2 1 4 16 1 a 9 10 11 11 11 L4 16 16 COUNTRY AMD lEP^HMCB NO HAKE Oft INITIALS DATE Oft ftlRTH COMPANY PACTOftV PIRST vc RIPOSURE DATS or DIAGNOSIS AGE AT DIAGNOSIS TEARS OP EXPOSURE TO DIAGNOSIS YEARS Op EXPOSURE DATE OP DEATH U1ST0LOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS YUGOSLAVIA 01 06.04.14 iup Vlall Spile 00.00.11 OS.04. 71 20 20 ua.04.71 Yaa SARIC at mi papt tnv Ileal tli PerapactIva V1 17, pp 169-192 1976 01 16.11.11 JuftO Split 00.00.10 11.07. 71 41 21 ia 11.07.71 Yaa* Vlall 01 11.11.11 J u|a Split 04.06.64 11.01.76 46 21 22 II.01.76 Yaa* Vlall VCM Pr odnet loa VCH Prodaction In lila lattar of 1 Oct 197ft, Dr Splrtaa of HIOSH changed Cm am 01 to VCM production eaployea. Dr Splrlaa alo notified a nau Ca Me 01 alao a VCH pr uduc t Ion writer 04 11.06.10 Jufto Split 15.12.66 01.09. 7ft 4ft 20 IS 01.09.7S Yaa Vlall Ruan KanJuahl Lattar of 19th June I960 and 1 ARC lattar ut 1 April till CMA 0 0 6 4 5 5 Page 30 TABLE 1 (Review Date - 1 Jan 1986) Incidence of ASL Cases Per Annum By date of death 1955 ...................................................................................... 1 60 7 ...................................................................................... 1 8 ............................................................................ 0 90 1960 .........................................................................................0 1 ...................................................................................... 1 21 3 ...................................................................................... 0 4 ...................................................................................... 2 5 ......................................................................................... 0 6 ............................................................................ 0 7 ...................................................................................... 1 8 ...................................................................................... 5 9 ...................................................................................... 3 1970 ...................................................................................... 2 1 ...................................................................................... 3 2 ...................................................................................... 5 3 .........................................................................................8 4 ...................................................................................... 5 5 .......................................................................................11 6 ....................................................................................... 11 7 .........................................................................................9 8 .......................................................................................10 95 1980 ....................................................................................... 10 1 ...................................................................................... 5 2 ......................................................................... 2 3 ...................................................................................... 9 4 ...................................................................................... 5 5 ................................................................................... O 3 Total 117 > N.B. 1 Does not include Italian 01 but does Include Cerman 03. 2 The 1977 total includes US case 24 which is a Cholanglosarcoma. O' -t> (.1 O' 3 The 1982 total does not include US 33 and P 15 who are alive. 4 The 1983 total does not include US 36 who is alive. Page 31 Distribution of ASL Caaes by Country TABLE USA W Germany France UK Canada Sweden Yugoslavia Italy Czechoslovakla Japan Belgium Norway 35 *** 26 ** 18 *** 11 10 5 **** 4 ***** 4* 2 2 2 1 (Review Date - l Jan 1986) 2 Total 120 trVOO ^W 3 * Omit ItOl - atypical case of PVC bag extruder. ** Includes GE03 aerosol can filler. *** Includes case US 24 which was diagnosed as Cholanglosarcoma A US 33, and 36; and F 15 who are alive. **** Includes one monomer worker. ***** Includes two monomer workers. l.e Western Europe North America Rest of World tn 'j 67 45 8 Total 120 P48 3,2 Pattern of ASL Cases by Factory TABLE 3 (Review Date - 1 Jan 1986) (a) W Europe Of the 67 cases in W Europe, 57 have occurred in clusters at 11 factories. Of the 26 Cerman cases, 23 have occurred in clusters at 4 factories. ASL Cases Dynamlt, Troiedorf, Germany Chloe Chlaie (Formerly RP), St Fona, France BP, Barry, UK Wacker, Burghausen, Germany Kemanord, Sundsvall, Sweden PCUK, Brlgnoud, France CWH, Marl, Germany ICI, Hi11house, UK Solvay, Tavaux, France Lonza, Ualdshut, Germany Solvay, Jemeppe, Belgium 11 8 8 7 5 5 3 3 3 2 2 57 NB: There are 32 pre 1962 PVC plants in W Europe; 18 of these have had ASL cases (Ref Table 8) (b) N America Of the 45 cases in N America, 38 have occurred at four factories out of a total of 54 factories:- In N America 43 plants have not had ASL cases. ASL Cases BFC, Louisville, US BFG, Shawlnlgan, Canada UCC, S Charleston Goodyear, Niagara 14 10 10 4 38 NB: There are 28 pre 1962 PVC plants in N America; 11 of these have had ASL cases (Ref Tables 9 & 10) (c) Rest of World The 8 ASL cases are believed to be in 1 cluster of 4 and 2 clusters of 2 cases. T,n>v f act 1 _ i moTfiPii nor *>7 CMA 0 0 6 4 5 8 Page 33 TABLE 4A (Review Date - 1 Jan 1986) Latency Periods (Years from first Exposure to Diagnosis) Country No of Cases Total Years Average W Europe Belglum 2 35 17.5 France 18 459 25.5 * Germany 26 495 19.04 * I taly 4 74 18.5 Norway 1 22 22 Sweden 5 122 24.5 N America UK 11 254 23.09 * 67 1461 21.80 US 35 886 25.31 * Rest of World Canada 10 204 20.4 * 45 1090 24.22 Czechoslovakia 2 30 15.0 Japan 2 39 19.5 Summary Yugoslavia 4 8 85 21.2 154 19.2 W Europe 67 1461 21.80 6 S fr9 0 0 VWO N America 45 1090 24.22 Rest of Uorld 8 120 154 2705 19.2 22.54 * Of the countries wlitth^ >> 10 cases. France, UK and USA have an average latency period above woi below world average. Page 34 DISTRIBUTION OP LATENCY PERIODS TABLE 4B (Review Date - I Jan 1986) 0-9 yrs 10-14 yrs 15-19 yrs 20-24 yrB 25-29 yrs 30-34 yrs 35+ yrs Total Average Latency Period Belgium 2 2 17.5 Canada 3 52 10 20.4 Czechoslovakia 11 2 15.0 France 1 4 3 5 2 3 18 25.5 Germany 5 9 9* 3 26 19.04 Italy 22 4 18 .5 Japan 11 2 19.5 Norway 1 1 22 Sweden 2 21 5 24.5 UK 1 4 42 11 23.09 USA 2 7 8 8 5 5 35 25.31 Yugoslavia 4 4 21.2 TOTAL 1 12 32 33 24 10 8 120 22.54 * Includes G 03 aerosol can filler WPX/ASL_2 - LANG10CASES,39 CMA 0 0 6 4 6 0 TABLE 4C Page 35 (Review dace 1 January 1986) * Cholangiosarcoma ** Aerosol can filler *** US33 and 36; and F15 still alive. WPX/ASL 2 - LANGIOCASES,40 CHA 006461 Page 36 (Review dace 1 January 1986) TABLE 4P LATENCY PERIODS OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION ~~ * Cholangiosarcoma ** Aerosol can filler *** US33 and 36; and F15 still alive WPX/ASL 2 - LANGIOCASES,41 CMA 006462 TABLE 4E Page 37 (Review date I January 1986) PLANT START UP DATE LATENCY PERIODS OF ASL CASES IN SPECIFIC PLANTS (10 OR MORE CASES) NO OF CASES AVERAGE LATENCY PERIOD LOUISVILLE USA SHAWINIGAN CANADA S CHARLESTON USA TROISDORF W GERMANY 1940? 1941? 1939? 1954 12,14,15,19,19.20,24,27,28,28,28,29,29 31 11,12,14,21,22,23,24,24,26,28 24,30,32,32,34,35,37,38,38,39 12,13,16,16,18,19,19,21,23,25,28 14 10 10 11 23.07 20.5 33.9 19 .09 WPX/ASL 2 - LANGIOCASES,42 CMA 006463 Page 38 (Review date 1 January 1986) TABLE 4F LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (10 OR MORE CASES) WPX/ASL 2 - LANGIOCASES,43 ChA 006464 PLANT SUNDSVALL SWEDEN BRIGNOUD FRANCE ST FONS FRANCE BARRY UK BURGHAUSEN W GERMANY NIAGARA USA Page 39 (Review date 1 January 1986) TABLE 4G START-UP DATE LATENCY PERIOD OF ASL CASES NO OF IN SPECIFIC PLANTS(4-9 CASES) CASES AVERAGE PERIOD 1945 16,19,27,29,31 5 24.4 years 1950 11,16,18,26,30 5 20.2 1939 21,28,29,37,38,27,41,35 8 31.88 1948 9,17,18,28,31,33,18,19 8 21.62 1933 17,21,22,25,24,13,21 7 20.43 1947 15,17,21,23 4 19 SPLIT YUGOSLAVIA 1941 20,20,22,23 4 21.25 WPX/ASL 2 - LANG10CASES,44 ^^6-465 Page 40 (Review date 1 January L986) TABLE 4H LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST (4-9 CASES) YEAR OF sundsvall BRIGNOUD ST FONS BARRY FIRST EXPOSURE SWEDEN FRANCE FRANCE UK 1939 1940 1 37 2 3 38 4 5 27* 6 31 29 7 29 8 28,34 9 26,30 1950 31,33 1 19 28 2 3 4 5 6 21 7 8 18 9 16 1960 1 2 18 3 17 4 16 5 11 19 6 18 7 8 9 1970 1 2 EXPOSURE AND BURGHAUSEN W GERMANY 25 21 22,24 17 21 13 SPECIFIC NIAGARA USA 15,23 17 21 PLANT SPLIT YUGC SLAV I 23* 20 22* 20 * Monomer workers WPX/ASL 2 - LANGI0CASES.45 CMA 006466 Pag 41 TABLE 5 (Review Date - 1 Jan 1986) Annual Incidence of ASL Cases (Date of Death) by Geographical Area 1955 7 1961 2 4 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980 1 2 1983 1984 1985 TOTAL Western Europe 1 1 1 1 4 1 3 6 6 6 7 5 6 5 1 6 4 2 66* ** North America 1 1 1 1 1 5 2 1 2 1 4 2 4 3 3 2 4 0 1 3 1 43** Rest of World 1 3 1 2 1 - 8 Annual Total 1 1 1 1 2 1 5 3 2 3 5 8 5 11 11 9 10 5 10 5 2 9 5 2 117 * Includes G03 aerosol can filler but omits It 01 bag extruder ** Does not include US33, and 36; and F 15. All still alive. Cumulatlve Total 1 2 3 4 6 7 12 15 17 20 25 33 38 49 60 69 79 84 94 99 101 110 115 117 Key Events Viola Hal ton! Goodrich CHA 006467 WPX/ASL_2 - LANGIOCASES,46 Page 42 (Review dace 1 January 1986) TABLE 6 ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING IT01) KEY EVENTS | WESTERN EUROPE ! NORTH AMERICA -- REST OF WORLD Viola Maltoni Goodrich 1955 0 7 8 9 1960 1 2 3 4 5 6 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980 1 2 3 4 5 Total FI Gl Swl G2 N1,Sw2,UK1,It2 G3** G4.G5.UK3 F2,F3,G6,G7,G8,It3 B1,F4,F5,F6,F7 ,Sw3 F8,F9,G10,Gll,Gl2,Sw4 F10,FU,G9,G13,G15 G16.G17 FI2,FI3,UK4,U1C5,G18 UK6, UK7,G19,Sw5,G20,G21 It4,F14,UK8,G22,G23 G26 UK09 ,It5,F17,B2,G24,G25 UK10, F16, F18, G27 UK11, UK12 66 Cl C2 US8 C3 US5 Cz2 C4,C5,US4,US7,US10 US12.US16 US11 C6.US2 C7 C8.US1.US3.US23 C9.US13 US6,US9,US18,US26 US19.US20.US22, C10.US21.US24* US27.US28 Y1 ,YZ,.Czl Japl Jap2,Y3 Y4 US17, US29, US30, US32 US31 US35 . US34. US38 US37 43*** 8 * Cholangiosarcoma ** Aerosol can filler *** Does not include US33, and 36; and F15. All still alive. WPX/ASL 2 - LANGIOCASES,47 CMrt 006468 Page 43 TABLE 7 (Review date 1 January 1986; ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION (EXCLUDING IT01) KEY EVENTS WESTERN EUROPE NORTH AMERICA REST OF WORLD Viola Maitool 1939 40 1 2 3 4 5 6 7 8 9 50 1 2 3 4 5 6 7 8 9 60 1 2 3 4 5 6 7 8 9 70 1 2 3 Frll,Frl6 Frl4 UK1 Sw2 Frl,Fr3,Sw4 Sw3 Fr9, Frl7 Frl2,Fr4 Fr7,Nl,UK8,UK9 Swl,UK5 G3** G15,It3,G26 G7,G8,UK4,G19 G11,G16,G18, Frl5*** G23.G28 FR10.G1 Fr8,G4,It2,G2,UK12 Fr6,Bl Fr2,It4 G5,G13,G25 G9,G10,G12,G17,G20,G22 G6,UK6,G21,B2 Frl3, UK7,Frl8 Sw5 Fr5,UK11 UK3, UK10 It5 G24 US24* C3.US27 US13, US29 C2,US19 Cl,C5,US5,US7,US28,US35 C4,US3,US9 C7,C9,US8,US11,US21 ,US31 C6.US22.US26 US1 US12 US16 US10, US32 Y2, Cz2 US4 CIO, US37 Japl.Yl US18.US33*** US2,US17,US20,US34 Y3 US36*** US23 Czl Jap2,Y4 C8 US6 US38 US30 Total 67 45 8 * Cholangiosarcoma (US24) ** Aerosol can filler (G3) *** US33 and 36; and Fr 15 are still alive. WPX/ASL 2 - LANGIOCASES,48 CHrt 006-469 Page 44 WPX/AL_2 - LGIOCASES,49 ff (Review date 9 January 1986) TABLE 8 WESTERN EUROPE FVC PRODUCERS - START-UP DATES V3 ASL GASES (CMUTDC GQ3 & It .01) START-UP ODUNECr NAME COMPANY NAME | LOCATION ASL CASE MJMSER YEAR OF YEAR 1st Exposure 1931 West Germany BASF Ludwigshafen 1933 West Germany Wacker !Burgbausen 04,07,11,15,23,24 25157,54.55,53.55.69,60 1938 Italy Montecatini lAcna 1939 France Rhone Poulenc 1st Ftxis 03,09,10,11,14, 46,48,56,41,43, 115,16,17 55,41,48 1940 United Kingdom ICI Runcorn | 1940 United Klngdan ICI Hlllhouse 01,04,12 44,54,57 1945 Sweden Kenanord Sundsvall(Stockvlk) 01,02,03,04,05 51,45,47,46,64 Switzerland Lonza Sins I 1946 France Rhone-Poulenc Roislllon 01 46 1947 Italy Montedison 1948 United Klngdan BP Chan Porto Marghera Barry 02 57 03,05,06,07,06,09166,51,62,63,50.50 110,11 [66,65 West Germany fills Marl 09,10,26 161,61,53 1949 Belgium Solvay Jemeppe 01,02 |58,62 1950 France Puk Brlgnoud 02,04,05,06,12 59,49,65,58.49 France Rhone-Poulenc St Auban 07 50 Holland Shell Pemis Norway Norsk Heroya 01 50 1951 Italy Montedison Brindisi 1952 Italy Montedison Temi 1953 Austria Halvic Halleln France Solvay Tavaux 08.13.18 57,63,63 Italy Solvay Ferrara 03 53 Spain Rio Rodano Hemanl United Klngdan BIP Aydiffe West Germany Hoechst Gendorf 18 55 1954 West Germany Dynanit Trolsdorf 01,02,08,12,16, 56,57,54,61,55,61, 17,19,20,21,22,27 54,61,62,61,55 1955 Spain Monsanto Iberia Monzon 1956 Spain Caiqsa Sabinanigo Hlspavlc Torrelavega 1958 West Germany Solvay Rhelnberg 1960 Italy S C Ravens Ravenna 04 59 1960 West Germany Lonza Waldshut 06,13 62,60 1962 Pomstal Clres Oporto 1965 France Rhone-Poulenc Montlucon Italy Pozzi Ferrandina West Germany Wacker Cologne 1966 West Germany Hoechst KnapaacWFrankfurt) 05* 60 1967 France AID Chlnde Ral Spain Rio Rodano Miranda de Ebro Greece Esso Pappas Dlavata Salonika 1968 Belgian Badiphil Antwerp 1969 United Klngdan Vinatex Staveley Italy Runlanca Cagliari SattHtm 1970 Italy SIR Porto Torres Sar United Kingdom ICT Runcorn 1971 Italy S C Ravenna Ravema Spain Hlspavlc Martorell Sweden Kananord Sternmgsund United Kingdom BP Chen Baglan Bay 1972 1976 Finland Holland France Pekena Svartback D31 Beek Linfcurg Soc Art D'vinyl Mszingarbe CMA 00647 , 1977 Spain Monsanto Iberia Tarragona * laboratory worker In Research Department PAtBAC, Mira Venice, case not Included (It 05), due not kncwing start up date of the Plant. Page 45 (Review date 1 January 1986) \ TABLE 9 USA EVC PRODUCERS - START-UP DATES vs ASL CASES |STAKT-UP| aWPANlf NAME IDCOTCN | ASL CASE YEAR OF 1 YEAR. 1 NUMBER 1st EXPOSURE 1939? |*UOC S Charleston 107,13,19,21,24, 44,42,43,46,39, 1 127,28,29,31,35 41,44,42,46,44 1940? *BEG Louisville j01,02,03,04,05, 48,55,45,52,44, 06,09,16,17,22, 62,45,50,55,47, 126,33.34.37 47,54,55.53 1946? *ucc Texas City (Partially closed 1977) 1947 Goodyear Niagara Falls [08,10,11,20 46,51,46,55 1948 Firestone Pottstown ]12 49 Uniroyal Painesville (closed 1975) 1950 Monsanto Springfield 32 51 (Closed 1975 1952 Dow Midland (No FVC since c 1975) ETC Avon Lake |18 54 1953 HPG Deer Park (Former'll7 Diamond) 1954 General Tire Ashtabula 36 56 (Closed 1984) 1956 Air Products Pensacola Atlantic Refining Brooklyn(Closed late 1960s) \ Borden Leominster (Closed 1984) Conoco Hebronville (Closed 1975) ETC Niagara Great American Fitchburg 23 58 Plastics (Closed 1983) Hooker Hicksvllle (Qosed 1980-81) Pautosoto Passiac (Qosed 1984) 1957 Atlantic Tubing Cranston (Closed 1967) Tenneco Flemington NJ 30 59 1958 Keysor Csitury Saugus, Cal 1960 BFG Watson, Cal Air Products Calvert City 38 63 (closed March 1982 Re-opened Octol*r 1983) Borden Illiopolis 1962 Tenneco Burlington NJ 1963 Conoco Aberdeen, Miss Stauffer Long Beach, Cal (Qosed 1982) 1965 Conoco ** Assonet, Mass (Qosed by Olin 1975 see below) Ethyl Batoa Rouge (Qosed 1984) 1966 Georgia Gulf Delaware City (Formerly Dianond) General Tire/Pantas Mt Pleasant W Va (Closed 1983) BFG Henry, 111 1967 Stauffer Allied Delaware City (Sold to Formosa 19) *** Painesville, 0 | (sold to Robintech) Hooker Burlington NJ | 1968 Firestone Perryville (Qosed 1982) 1969 BFG Pedrickton NJ Goodyear Plaquanine Olin ** Asscnet, Mass (Qccnd 1975) (See at>cwe) (Formerly Conoco) 1971 Conoco Oklahoma City WEX/ASL 2 - LANGI0CASES.50 Continued 0064?i Page 46 TABLE 9 (Continued) USA PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP| COMPANY NAME YEAR | 1972 1973 1 Nat Starch Borden Robintech *** 1974 1975 1979 1983" Atlantic Tubing/ Tallyrand Shintech Certain-teed Georgia Pacific Tenneco Firestone Formosa | LOCATION 1 | ASL CASE ! NUMBER 1 Meredosia, 111 1 Springfield 1 | Painesville, 0 | (sold to Georgia | Pacific who | converted to | polystyrene) | Cranston RI (Closed 1982) 1 Freeport, Tex | Lake Charles Plaquemine, La Pasadena, Tex Plaquemine Point Comfort, Tex | YEAR OF i 1st EXPOSURE 1 j 1 1 1 ""!'' i * My databank has no information on UCC before 1946 or BFG before 1950 ** Refers to same plant at Assonet ***Refer to same plant at Painesville. Allied plant never operated again for PVC after it was sold to Robintech. NB Some of the plants in this list were closed down, some have changed ownership over the years, some have changed their product. WPX/ASL 2 - LANGIOCASES,51 CMA 006472 Page 47 TABLE 10 (Review date 1 January 1986) CANADIAN PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP YEAR COMPANY NAME 1943 (1941?) Goodrich 1951 Monsanto LOCATION Shavlnigan ASL CASE NUMBER | YEAR OF I 1st EXPOSURE 1 01,02,03,04,05 44,43,41,45,44, 06,07,08,09,10 147,46,61,46,53 t La Salle (Closed 15 '75) 1957 Goodrich Welland 1966 Esso Sarnia 1979 Diamond Shamrock Alb Fort Saskatchewan WPX/ASL 2 - LANG10CASES,52 006-473  T> Page 48 (Review date 1 January 1986) TABLE H EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASL CASES START-UP COUNTRY NAME COMPANY NAME YEAR Pre 1939 East Germany State Company 1941 Russia State Comps 1950 Yugoslavia Jugo Vinil 1951 1955 Czechoslovakia State Comps East Germany State Comps 1956 Rumania State Comps 1957 Poland State Comps Rumania State Comps 1958 1959 1961 1963 1965 1967 1969 1970 1972 1975 1976 1977 Rumania State Comps Hungary State Comps Rumania State Comps Yugoslavia Ohis Bulgaria State Comps Poland State Comps Russia State Comps Rumania State Comps Russia State Comps Yugoslavia Vinilplastika Czechoslovakia State Comps Russia State Comps Yugoslavia Hip Rumania State Comps LOCATION Schopau Vladimir et al Split iNovaky |Bitterfeldt |Icechim lOsweicim (Dwory) Tirnaveni Turda Risnov Berente Borsod Borzesti Skop1e Varna Tarnow D.lerlinsk Rimnicu Vilcea Volgograd Zadar Neratovice Kalush Area Pancevo Rimnicu Vilcea ASL CASE NUMBER 01,02,03,04 01,02 s | YEAR OF | 1st Exposure 1 1 53,50,54,48 57.50 WPX/ASL 2 - LANGIOCASES,53 CMA 006474 Page 49 (Review dace 1 Januarv 1986 TABLE 12 JAPANESE PVC PRODUCERS - START-UP DATES vsASL CASES START-UP YEAR 1950 1951 1952 1951 1955 1956 1957 1960 1964 1966 1967 1968 1970 1971 1973 1974 COMPANY NAME Chisso Corp Kanegafuchi Kag Tekkosha Mitsui Toatsu Mitsubishi Mon Sumitomo Kag Denki Kagaku Nippon Zeon Toa Gosei Ryo-Nichi Nippon Zeon Nisshln Kagaku Kureha Kasel Shinetsu Kag Denki Kagaku Kanegafuchi Kag Chisao Corp Tokuyama Seksui San Arrow Kagak Sumitomo Kag Ryo-Nichi Shinetsu Kag Chisso Corp Denki Kagaku Kanegafuchi Kag Kawasaki Yuki Mitsui Toatsu Nissan Kagaku Shinetsu Kag Tekkosha Asahi Glass Toyo Soda 1975 1977 Central Kagaku Toyo Soda Unknown LOCATION Minamata Osaka Sakata Nagoya Yokkaichi Kikumoto Shibukawa Kambara Tokushima Uozu Takoaka Takeo Nishiki Naoetsu Ohmi Takasago Chiba Tokuyama Tokuyama Chiba Mizushima Tokuyama Mizushima Goi (Chiba) Kashima Kawasaki Sakai Chiba Kashima Yokkaichi Hayatsukl Sakata Yokkaishi Kawasaki Yokkaichi Kashima ASL CASE NUMBER YEAR OF 1st EXPOSURE 01, 02 53, 58 WPX/ASL 2 - LANGIOCASES,54 CMrt 006475 Page 50 (Review date 1 January 1986) TABLE 13 SOUTH AND CENTRAL AMERICAN PVC PRODUCERS START-UP| COMPANY NAME YEAR | 1953 1 Monsanto Mexica 1954 Policyd 1955 1956 1960 Geon Do Brazil Elchlor Electrochlor Viplastic 1961 1965 Indupa (SOC Paramanga (1967 start up PET Columbiana 1966 1967 1968 Carburo De Col Plasticos Omega Primex 1970 Policasa Petro Dow 1971 Polimeros Mex 1975 Rico Chemicals 1976 1977 Petroplas Indust Resistoc 1978 Huls Brasil Polychem Policyd 1979 PET Camacari LOCATION Lecheria (Mexico) Mexico City (Mexico) | ! 1 | Sao Paulo (Brazil) Sao Caetano (Brazil) Capitan Bermudez(Argentina) Mendoz (Argentina) Cinco Saltos (Argentina) Paramonga (Peru) ) Cartagena (Colombia) Medellin (Colombia) Mexico Puebla (Mexico) Managua (Nicaragua) Conception (Chile) St Martin Puebla (Mexico) Guyanilla (Puerto Rico) EL Tablazo (Venezuela) Tlazcala (Mexico) Cubato (Brazil) El Salvador Coatzacoalcos (Mexico) Camacari Bahia (Brazil) ASL CASE NUMBER ] YEAR OF ! 1st EXPOSURE | I 1 WPX/ASL 2 - LANGIOCASES,55 CMA 006476 Page 51 (Review date X January 1986) TABLE 14 AUSTRALASIAN PVC PRODUCERS START-UP TEAR COMPANY NAME Mid 1950s ICI Australia 1960s B F Goodrich Late 1970s ICI Australia LOCATION Botany, Sydney Melbourne Laverton Melbourne ASL CASE NUMBER I YEAR OF | I 1st EXPOSURE I --------------------- 1 ii i( i1 I ii ii WFX/ASL 2 - LANGIOCASES,56 CMA 006477