Document 02zwyZbODwp8OnaGqkBYz9NM

April 8, 1957 Mr, James 0, Lofotrom Standard Oil Gortpany 30 Kook*fell*r Plaza New York 20, How York Demr Mr, Lofstromi I have boon asked to forward to you toxieit^-^ata^jai our fluids, Pydraul 7-9, Pydraul 150, Pydraul 600, and Pydraul A<Tx &*&*klzS. There has been considerable toxicity research on Pydraul P-9, Attached la a dleousslon and Interpretation of the toxlolty studies. The result* are also summarised in a briefer fashion on page 18 of the attached Pydraul 7-9 Technical Bulletin. The tenacity report on Pydraul 150 indicates that it is practically InnootMmr men fed orally to rats since the animals survived single dotes of 28,5 gramo per kilogram with lose of appetite and sever* diarrhea as the only tootle effoots. The fluid apparently is not absorbed through the unbroken skin of rabbits ainee this species survived doses up to 9#5 grans per kilogram of body weight. In rabbit skin and eyo irritation studies, Pydraul 150 was no more irritating than a lOjf soap solution tested similarly. As indicated with Pydraul 7-9 above, however, Pydraul 150 will cause severe pain if there is sooldental splashing in the eyes of humans, Rats survived a 6-hour exposure to an atmosphere saturated with Pydraul 150 vapors, Pydraul 60Q The oral lethsul dose for rata iu approximately 30,5 grams per kilo gram, When applied undiluted to the unbroken skin of rabbits tbj lethal dose woe from 3*9 to 5.2 grams per kilogram. Animal skin and eye irritation studies indicated that Pydraul jOO la not a skin irritant, We know from experience with humans that accidental splashing in the eyes does cause severe pain but no permanent injury. Rats survived a 6-hour exposure to an atmosphere saturated with the vapors of Pydraul 600, DSW 018676 STLCOPCB4005220 Mr* Jsns 0. Iof8trora--Pae 2--Aprll 8, 1957 Tha oral lethal dooe In rats Iv approximately 40 irons* par VdUo^rea jnd th-i ftiaiwutt iuthal dooo b/ u'vin absorption (in ras' ) i c.iy to 5.0 &;** per kilogram. Rabbit akin and eye Irritation studi** indicate that ?ydraul AO Is nut a aorloua irritant. Accidental acmtaot xlth the eyea in the case of humans will result in Irritation but no permanent daage, .late survived a 0-hour atpoaure to an at&oepher* saturated with vapora of Pydraul .10. if I oan bo of any further ;-&r. 1st once, pleaa lot rto know. Sincerely yours, STVidh Enclosures o Mr. M. 9. Pi-owner Elmer P, '.'^heeler Aeeletart .Oir<K>tor Medical Dopartaent . jffll 'I'ittvrn .1- DSW 018677 STLCOPCB4005221