Pathology Review of Reported Tumorigenesis in a Two Year Study of FM-3924 in Rats November 25,1998 BY Pathology Associates International 6217 Centre Park Drive West Chester, Ohio 45069 Telephone (513) 779-9600 Fax (513) 779-9603 003099 Pathology Review of Tumors Reported in Rats Given FM-3924 Introduction: This report presents an independent assessment of tumorigenesis data obtained from a study to determine the chronic toxicity and carcinogenic potential of the fluorochemical FM-3924 in rats.

ARnt- ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SUBSTANCE Identity: e2rFPet9Cehf9er-yf11rllr-u2-eN5o7d1-r,[o-(tF7oho)Cecatp-as1tna2Ped9Fse,OucFlaSfCofAl-nu1Ayo0,lra9oFm,oCFcid-tC1yo-l2()1es80tuh9olyf-roXl)anasyoclrte]h-Rt,ea1ptem9o;0taa4mjso.asriy(ucGomalmlyscsopianolbetn,e,eCNnAt-Sof# Remarks: The test sample is FC-129 referred to by the test laboratory as R1904.

M a ,se _ 6s ~5 PFOS 3Pharmacokinetic - 000163 * l-`i ci O 28 Day Percutaneous Absorption Study with FC-98 in Albino Rabbits r e c'A Mti i i t w T 6 )L\C ctifyf Experiment No.

A R S 2 6 . 0705 ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SUBSTANCE___________________________________________ Identity: Mixture containing perfluorooctanesulfonate which may also be referred to as PFOS, FC-95, or as a component of FC-201F. (1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-, potassium salt, CAS # 2795-39-3) Remarks: The 3M production lot number was 1.

0750 ACUTE TO XIC ITY TO FISH TEST SUBSTANCE________________________________________________ Identity: A mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-95, or as a component of FC-203CE. (1Octanesulfonic acid) (CAS # 2795-39-3).

Ak R A 6 - 0 7 6 3 MICROBICS MICROTOX TOXICITY TEST TEST SUBSTANCE____________________________________________ Identity: Mixture containing perfluorooctanesulfonate which may also be referred to as PFOS, FC-95, or as a component of FC-203FC. (1Octanesulfonic acid) (CAS # 2795-39-3).

TO XIC ITY TO AQUATIC PLANTS TEST SUBSTANCE Identity: A mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-95, or as a component of FX-3103. (1Octanesulfonic acid) (CAS # 2795-39-3).

AR Z 6 - 0 3 * 0 ACTIVATED SLUDGE RESPIRATION INHIBITION TEST TEST SUBSTANCE_______________________________________________ Identity: A mixture containing perfluorooctanesulfbnate, whichmay also be referred to as PFOS, FC-95, or as a component of FX-3104. (1Octanesulfonic acid) (CAS # 2795-39-3).

3M Specialty Materials 3M Center FihoWO- /37gSt.

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^PRO 1 AZ 1 2 6 - I07Z UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 MAR 1 1 2002 OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES Dear Interested Party: Attached please find copies of two related documents that published in today's Federal Register: a Final Rule (67 FR 11008) on 13 known discontinued perfluoroalkyl sulfonate (PFAS) chemicals making any new manufacture or importation a significant new use; and a Supplemental Proposed Rule (67 FR 11014) on 75 additional chemicals, proposing to exclude from the definition of "significant new use" specifically defined, low volume, controlled exposure uses in semiconductor manufacture, aviation hydraulics, and photography, but to otherwise require submission of a significant new use notice (SNUN) for any manufacture or import of these chemicals after December 31, 2002.

39 ff UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 1133 OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES 21 October 2002 MEMORANDUM: SUBJECT: Focussed statistical analyses of APFO data on >and preweaning loss g?

NORTHERN KENTUCKY OFFICE SUITE 340 1717 DIXIE HIGHWAY COVINGTON, KENTUCKY 41011-4704 606-331-2936 513-331-2839 FAX 513-381-6613 ROBERTA.

fi- R S .0 .& Document 10 of 20 _ u q if .

di f>p M A6 - I & 1 S ' March 21, 2003 ToMUEW1:2P.aaS0Ars.0yhEEiPFnnae.gvsnDttino,roosnMymn, lamDviinaleCinnaCiktaoa2ld0Ae4Pv6r7eo04nt0euc5etM,ioNnWAgency From: Katie Smythe, on behalf of the Telomer Research Program Subject: Final Study Report - Submission to AR-226 ret==o>> ~7rXo03 "T--O3rOrnn Of-rj ro tOhne UbeShaElPfAofftohreiTncelluosmioenr RineAsedamrcihniPsrtoragtriavme R(TecRoPrd), 2th2e6:following study report is submitted to B[TiohicsotnecsetnwtraastipoenrfToersmt eodf 2u-spinegrfl2u-o(proearfllkuyolro(Coc=t4y-l1)6e)thEatnhoalno(Tl einstCsuarbpstance number K1518)] NtIIdonniorsdpettueirctso:tutlvrtyTeyid,bh(eJuiMsattphsEaaetrTunrsda.It)nyuTgadwehnydadersefsthoctpueorodnrtfhytdinetuwoactlarttaehsrnedespspbUloaoyrStntiKoswEonuParreosAudfpm.trbheoyevLtirhadeebepodoJrartatpotiaontnrhtyoeM-ETinRCngiPhslet.irsmyhTi.ohcaefMlEsTEcREoTPvnIaodglmuiadavyten,iooTTntrRafauPdnnedpdaeRntrhmedesiessastruicodhny TonheisorfetphoertitwemassmtheantttihoeneTdRiPn twhoeuMldasrcuhbm14it, t2o0E03PATRinPMLeatrtcehr 2o0f0In3.tent - Appendix 3 (p. 11) as N(CoBnIe)oufntdheeraTttSaCchAe.dNfioletshicnogntianinthiinsftorarmnsamtiiosnsicolnaiims TedSCasACCoBnfIi.dential Business Information ooooov