.~| -r- I I ^ Spectrographic analysis for load of samples of urine from 4 men* Samples collected before exposure to lead tetraethyl and Immediately after cleaning a tetraethyl fluid tank, using special Ethyl Gasoline Corporation nen equipment at Standard Oil Company of Louisiana plant at Baton Rouge* Dr* Machle, Hame Mgs Pb/Ll ter Before Exposure o.o6 0,09 0.07- o.o8 Mgs Pb/Liter After Exposure 0*11 0*09 0.13 0.l4 Reported ; 4-10-19 HZ 0022301 \

There is absolutely nothing in the Public Health Bulletin from which he quoted to indicate that there might be any danger of lead absorption as the result of exposure to gasoline containing tetraethyl lead* He must have either mis-understood what I had to say, or he must have mis-quoted me, I dare say what happened is that he confused certain statements.of mine as to the toxicity o f 'feetraethyl lead with the experimental evidence . on leaded gasoline* This may or may not be of any importance to you, but if you find it possible to present evidence that j\ have been mis-quoted or mis-interpreted by Dr* Baker, it might be useful to let me know exactly what ha ha3 said in order that I may straighten out the points at issue.

One L of gasoline contains 0.4 - 0.6 cc tetraethyl lead=425-340 mg of "pure'' Pb, 0.6 being the maximum permissible concentration in both Swiss and German gasolines.

Kehoe: I am writing to request whether or not you might be interested in giving me your medical opinion concerning the .physical status of one of our tetraethyl lead workers who had an unusually large exposure to tetraethyl lead in August, 1968 and who persists in showing insidious mental changes.

It produces a clinical pioture of lead poisoning, which is different from that associated with any other lead compound, as you will see from the article describing the clinical tetraethyl lead poisoning.

ABSTRACTS FROM CURRENT LITERATURE 537 Praxis of an Industrial Laboratory for Prevention of Tetraethyl Lead Poisoning.

One L of gasoline contains 0.4 - 0.6 cc tetraethyl lead=425-640 mg of "pure1' Pb, 0.6 being the maximum permissible concentration in both Swiss and German gasolines.

We have studied this problem with a great deal of care, and perhaps I should point out briefly what seems to occur* Under the conditions of storage of leaded gasoline in tanka, there la a 3light decomposition of tetraethyl lead in the formation of organic lead compounds in the sludge at the bottom of the tank, which seem to be capable of reforming small quantities of tetraethyl lead.

The lo w va lu e s o btaine d on the u rin e d e m o n s tra te c le a r l y that th e s e m e n did not abs o rb s ign if of lead as tetraethyl lead or in any other form . _/ Signed: Ro b e rt .

It produces a > clinical picture of lead poisoning, which is diffrent from that associated with any other lead compound, as you will see from the article describing the clinical tetraethyl lead poisoning.

It produces a clinical pioture of lead poisoning, which is different from that associated with any other lead compound, as you will see from the article describing the clinical tetraethyl lead poisoning.

ETH00003584 TETRAETHYL LEAD (LEAD TETRAETHYL, TEL) Pb (C2II5)4 From Ethyl Chloride and Lead-Sodium Alloy Crushed leadsodium alloy Ethyl chloride Condenser |--By-product gases Ethyl chloride Ethylene dibromide Ethylene dichloride Autoclave Water Dye XJ~ -Waste Blender TEL Water Lead ^ {to recovery) Washer Brine (to waste) Antiknock fluid containing Tetraethyl lead Reaction 4NaPb + 4C2H5C1 -* Pb(C2H5)4 + 3Pb + 4NaCl 85-90% yield (based on sodium) Material Requirements Basis--1 ton tetraethyl lead (100%) Sodium Lead (theo) Ethyl chloride (theo) Catalyst Ferric chloride Sodium thiosulfate 650lb 1,280lb 1,595 lb 15 to 50 lb Small Small Process Tetraethyl lead is made by reacting a lead-sodium alloy with ethyl chlo- r'de in an 'oclave.

Vinether it is due to tetraethyl lead is very questionable, in fact, I third; it quite unlikely, but he apparently has been able to give the impression of genu ine mritai upset, which, as we know-, would be considered a likable possi bility of tetraethyl lead poisoning

If it should turn out to be analogous to lead tetraethyl, which I tend to doubt, the scope of the toxi cologies investigation could be curtailed greatly.

Warren outlined the interest of the company in the industrial hygiene of tetraethyl lead over the past 30 or more years, and invited Mr.