Denning Staff Associate, Natural Resources and Environmental Quality U.

., New York, a supplier of fragrances and flavors to the food, drug, cosmetic, toiletry and perfume industries, introduced an improved synthetic chocolate flavor.

The Cosmetic, Toiletry and Fragrance Association, Inc. 1133 15th STREET, N.W., WASHINGTON, D.C, 20005 202/331-1770 TELEX 89-2873 TO: Talc Subcommittee FROM: Charles R.

Richland, WA 99352, USA (Accepted 16 June 1994) Summary--A review of the literature reveals two primary issues: (1) a weak, but not causal, association of hygienic use of cosmetic talc and ovarian cancer; (2) lung changes in animals exposed to talc aerosol concentrations that resulted in lung overload.

Cramer's study is an epidemiological one, which merely examined factors which might be associated with the disease.

A review of the selected titles reveals two primary issues, namely (I) hygienic use of cosmetic talc and ovarian cancer risk, and (2) health effects of inhaled cosmetic talc.

Chlorite one of the most common accessory minerals found associ- samples clay ated with talc was not identified in any of the although their | may in fact be chlorite We have examined some of the identical samples reported on by agree Snider et al and cannot with their interpretations of anhydrite .

Toiletry and Fragrance Association, tnc.

JOSEPH C KELLER JCPOMEH HECKMAN CHANLCSM MttMAN WILLIAM M BOROHCSANI.

Overseas, we have introduced such products in Paki 'Includes earnings from Associated Companies.

End, Associate Commisricmer lor Compliance.

Passes test 100% through 100 mesh 98% minimum through 200 mesh Finer grades: as specified by the buyer 0.1% maximum As specified by the buyer 6.0% maximum 5.0% maximum 3 ppm maximum 20 ppm maximum None detected METHOD Heat 1 to 2 g at 200C for 5 minutes CTFA G 3-1 ASTM D 934-74 USPXiX, page 487 CTFA C 6-1 USP XIX, page 487 See test for " Reaction an Soluble Substances" CTFA E 32-1 USP XIX, page 487 CTFA F 1-1, Parts l-A an< CTFA F 2-1, Parts l-A am CTFA J 4-1 As specified by the buyer * a it -a * CTFA J 5-1 (DTA) Alternate: CTFA J 6-1 (X-i Copyright 1976 The Cosmetic, Toiletry and Fragrance Association, Inc

Food and Drug Administration FDA was weighing limits on asbestos in cosmetic talc products & assured the regulator that no asbestos was detected in any sample of talc produced between December 1972 and October 1973.

Weiss This control study evaluated the risk of epithelial ovarian cancer associated with various forms of powder application Cases included all genital exposure to women aged 20-79 years in three counties of western Washington who were diagnosed with borderline or invasive ovarian cancer from 1986 of eligible cases were interviewed A sample of similarly aged women who lived in thestehrcoouugnhti1e9s8i8de6nt4if.ie3d by random digit dialing served as controls The overall response among control women was 68.0 Information on powder application and other potential risk factors was ascertained during the person interview Overall ovarian cancer cases n = 313 were more likely than controls n = 422 to ever have used powder adjusted relative risk RR = 1.5 95 confidence interval CI 1.1-2.0 After adjustment for and other methods of genital powder application none vs. any an elevated relative risk of age ovarian cancer was noted only for women with a history of perineal dusting RR = 1.6 95 CI 1.1-2.3 or use of genital deodorant spray RR = 1.9 95 CI 1.1-3.1 These results offer support for the hypothesis raised by prior epidemiologic studies that powder exposure from perineal dusting contributes to the development of ovarian cancer and they suggest that use of genital deodorant sprays may do so as well Limitations of the present study include the fairly low proportion of eligible women who participated and the potential differential recall of powder usage Am J Epidemiol 459 65 ovarian neoplasms powders talc asoline a 111-14 ernational 1995 .

That assertion, backed by decades of solid science showing that asbestos causes mesothelioma and is associated with ovarian and other cancers, has had mixed success in court.