DuPont Chemical Solutions Enterprise Barley Mill Plaza 23/1324 Lancaster Pike and Route 141 Wilmington, DE 19880-0023 TABLE OF CONTENTS SECTION_________________________________________PAGE .

C O V /H H > THE DEVELOPMENT SERVICES COMPANY Sponsor: APME Ad-Hoc APFO Toxicology Working Group FINAL REPORT Study Title: 4-Week Capsule Toxicity Study with Ammonium Perfluorooctanoate (APFO) in Cynomolgus Monkeys Author: Peter J.

Ever DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE, USA Abstract The objective of these studies was to evaluate the subchronic, reproductive, and deve toxicity of a fluoroalkylethyl ethoxylate surfactant in rats.

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ITnhiteiealflfyemcetasosufr1e-dDeac..ancooln,ce3n.t3r,a4t.i4o5n.5a.r6e.6s,u7m,7m,a8r,i8z,9e,d9.i1n0T,a1b0l,1e01-hepladocafluoro- based on 000050 R Bm ssM sem-- crepes [] onition of siomass growth mais Cee TTT 000051 DR.U.NOACK-LABORATORIUM FOR ANGEWANOTE BIOLOGIE 1R-eDpoorcatnol, 3.34,4,5,5,6,6.7.7,8,89,9.10,10,10-hepC tadecafivoro- T Papeso v`Ailtgha,thGeroWwattherInAhicbciotimomnoTdesattewidthFrSaccatnioend(eWsAiRmu)s,asucbcs.piOcEatCuDs,27021 h, Limit Test PStruodjyeecNto-.NoS.500280410181C2K 2 Characterisation Data of the Test item TEST ITEM 1-Decanol, 3,3,4.4,5,5.6.6.7.7.8,8.9.9,10,10,10-heptadecafluoro- Batch number PODIOOT CASRN 678-397 `Chemical characterizatio/n 3,3.4.4,5,5,6,6,7.7.8,8,9.9.10,10,10-heptadecafluorodecans-1-of `Active ingredient (EINECS) Purity (sCuBm-peprofrlfuiourooraolaklyklyeltehtahnaonlol999.93.9%%(a(laal)a,) Appearance Yellowish solid wax `Water solubility 134 137 pg gL at at 12 25 degree degree C, C, Std Std 29 53 git, ugiL, n= (DuPont, 2002) n=17 (DuPont, 2002) Stabilty in water Stable at test conditions Density Ca. 17 glem" Expiry date.

(dba Exygen Research) (Exygen) from DuPont Corporation.

Experimental A sample of HFE-7100 (36% n-C4F9OCH3 and 64% i-C4F9OCH3, >99% pure) was obtained from DuPont-Mitsui Fluorochemicals Co.

. ;.j . 3-*'Vii :; U t' CONFIDENTIAL DPT439/984974 ACUTE TOXICITY TO FISH Sponsor DuPont Speciality Chemicals, Jackson Laboratory, Chambers Works, Deepwater, NJ 08023, USA.

DuPont de Nemours and Co., Inc., Wilmington, Delaware.

West, D.V.M., ACLAM DuPont-2032 Supplement No | Company Sanitized.

LeYW:^;:W(;,jf|alx^r,- +44:{0)il4M;8S>2W: E^aa^MdiaA iPatei-yjanumyij^ ACUTE ORAL TOXICITY TO THE RAT (FIXED DOSE METHOD) Sponsor DuPont Specialily Chemicals Jackson Laboratory Chambers Works Dsepwater NJ 08023 USA Page 1 of 17 Research Laboratory Huntingdon Life Sciences Ltd P.O.

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RNA84111 2 Characterisation Data of the Test Item TEST ITEM Batch Number CAS RN Chemical characterization Purity Appearance Water solubility Stability in water Density 1-Decanol, 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro- P00/001 678-39-7 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecane-1-ol (EINECS) C8-perfluoroalkylethanol: 99.8 % (a/a), sum perfluoroalkylethanol 99.9 % (a/a) Yellowish solid wax 134 pg/L at 12 degree C, Std 29 pg/L, n=8 (DuPont, 2002) 137 pg/L at 25 degree C, Std 53 pg/L, n=17 (DuPont, 2002) Stable at test conditions Ca. 1.7 g/cm3 Expiry date Recommended storage Storage at testing facility Retention Identification parameter at testing facility Unlimited if stored under the recommended conditions.

D-- o-- ss ot-- con-- tain TSCA CBI H-25231: OneGeneration Reproduction Study in Rats --~ DuPont.9763 APPENDIX FF INDIVIDUAL ANIMAL PATHOLOGY DATA - P; ADULTS ~~ -- 7 - Company Sanitized.

%t M^i 0 V J' not conta* TSCACBl ' c o m p a s sanM M d- DOeS -riiv CONFIDENTIAL DPT440/992118 ACUTE TOXICITY TO DAPHNIA MAGNA Sponsor DuPont Speciality Chemicals, Jackson Laboratory, Chambers Works, Deepwater, NJ 08023, USA.