Shin-ya4 TRP* Toxicology Program, 'DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware, USA 2Clariant GmbH, Sulzbach, Germany 3Daikin Industries, Inc., Osaka, Japan 4Asahi Glass, Co., Ltd., Tokyo, Japan Abstract Preliminary to a repeated dose toxicity assessment, a range-finder study involving repeated oral doses o f 8-2 Telomer B Alcohol was conducted in rats to determine the time needed to reach steady-state as determined by total organofluorine blood fluoride levels.

f' 7.1 AttscTiriantA:ChainofCustody 72 Attachmenta AnalyticalBeaut f t SQ paeftW pe & essa /OqojhLnM.FIaiiarfy,VloRrosldBrt-- MONOM EID871404 7 3058 Research Drive State College, PA 16801 Phone: 814-272-1039 Fax: 814-231-1580 L o q in Login Group; 10003000 LPorogjinec#t: 3110 P00009S9 Company Name: DuPont da Nemoure & Co, tow.

Does not contain TSCACBS H-23004: Skin Irritation Test in Rabbits DuPont HL-1997-01294 TABLE 2 INDIVIDUAL SKIN IRRITATION SCORES AND SKIN RESPONSES OBSERVED IN RABBITS RABBIT NUMBER 32186 32402 32381 32406 32407 32410 HOURS AFTER TEST SUBSTANCE REMOVAL ERYTHEMA EDEMA 1 24 48 75 1 24 48 75 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 1 1 0 0 0 0 0 1 0 0 0 0 0 0 0 1 1 1 0 0 0 0 0 -10- Compa"lf Sanitized.

Material Flow et 1 Non-Fluoropolymer Products 3M exiting production and marketing Dyneon will not market APFO Dupont and Daikin announced they will only sell APFO to "experienced and responsible users" in the Fluoropolymers industry. 6 tonnes (12,500 Lbs)/yr (3M global sales) ------> ZERO 8 Possible Sources of Exposure FPA Manufacture Nom-FPlruoodruoctpsolymel Fluoropolymer Manufacture Dispersion Fluoropolymers PPooipnutlaStoiuornceExEpmoissusrieons ----Material Flow = T i i i i i i i }i i General PEoxppuolastuiroen 9 Pron impuries in POSF Related Materials [etomer | Based | Materials Trans- formation PFOA_| [SBulafsoenadte Materials Blank Slide CBI Redacted Blank Slide CBI Redacted Possible Sources of Exposure FPA Manufacture Non Fuorapolymer Products Fluoropolymer Manufacture FiluDoirsoppeorsliyomners uoropolys } Exposure I i i i i 3 i i |i i i ry Impurities in POSF Related Materials Trans- formation 10 PFOA Tetomer Based Materials Sulfonate Based [Materials Point Source Emissions.

The internal sMtOandards used were a dual labeled PFOS where two '*0 molecules were included in the sulfonate group intemal standard, >99% purity, synthesized by Research Triangle Institute, Research Triangle Park, NC) and a dual labeled PFOA molecule, where the carboxyl and alpha carbons were labeled with C stable isotope (greater than 97%, provided by DuPont, Wilmington, DE).

I ZI-b RECEIVED OPPTNCIC 2003APR30 PM * 5 2 FLUORINATED SURFACTANTS IN FIRE FIGHTING FOAMS: ANY INPUT FOR WATER MIST TECHNOLOGY Martial PABON, PhD DuPont de Nemours (France) Chantereine, Mantes le Ville F-78202 Mantes la Jolie Cedex ZONYI/ .1 ORAI AC- !

Ladies The DuPont Company, Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware, USA , B M Abstract The objective of this study was to evaluate the subcltronic and reproductive toxicityo f a fluoroalkylethanol mixture which is employed as an intermediate in tlte production ofother fluoroorganic compounds utilized as protectants and surfactants.

EXP000612 I V Landfills On-site Summary Item Landfill Type Site 1 Engg Cap Site Wells 15 Sampling Events Over 20 On-site PFOA Range 0.058-30,500 (PPb) Site 2 Active 13 10 NQ-22.8 On-site PFOA Mean (PPb) GW-SW Flow (gpy) PFOA Flux (lbs/yr) 2763 525,600 4.03 2.87 6,664,900 8.65 Site 3 Soil Cover 9 8 NQ-65.9 17.7 2,482,000 1.01 EXP000613 V Flux Calculation EXP000614 Groundwater Investigation Steering Team (GIST) EXP000615 i GIST Offsite Summary-3 Landfills Item GIST Offsite Sample # Off-site Samples Offsite PFOA Range (ppb) Offsite PFOA Mean (PPb) Sitel l-mile 30 ND-0.636 0.04 Site 2 l-mile 53 ND-0.974 0.185 Site 3 2-mile 109 ND-14.3 1.46 EXP000616 Landfills-Overall Impressions Landfills are regulated by state permits Permits require: - Engineering controls - Monitoring plans Our experience demonstrates: - Engineering controls are effective for PFOA - The monitoring conducted indicates minimal PFOA contribution to the environment Actions The other Fluoropolymer LOI signatories w ill compare the DuPont data with their industrial landfill data in order to develop an understanding o f the contribution o f other landfills to PFOA environmental loadings 8V9000dX3 }. ....

Shin-ya4 TRP* Toxicology Program, 'DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware, USA ^lariant GmbH, Sulzbach, Germany ^aikm Industries, Inc., Osaka, Japan ^sahi Glass, Co., Ltd., Tokyo, Japan Preliminary to a repeated dose toxicity assessment, a range-finder study involving repeated oral doses of 8-2 Telomer B Alcohol was conducted in rats to determine the time needed to reach steady-state as determined by total organofluorine blood fluoride levels.

IH3 by LCZMS/MS- Revision 2 AUTHOR Emily Decker DAm T O i t January 8,2004 SPONSOR DuPont Nyaric, DP.EO.1B9o7x145-00050USA in Serum Sciences g LABORATORY St3a0tEe5xC8yogRleleefscgeReaVrecsPheAaDr1cr6hiv8e01 ^1M >JW M BER ExM-008-276Revision 2 TOTAL NUMBER OFPAGES 20 CompanySanitized.

i PARTITION COEFFICIENT AND ADSORPTION/DESORPTION Sponsor DuPont Specialty Chemicals Jackson Laboratory Chambers Works Deepwater NJ 08023 USA Research Laboratory Huntingdon Life Sciences Ltd.

Please send me all documents related to physical, telephone or video communications and meetings (including diary entries, notes, minutes, correspondence produced before and after the communications and meetings) between DEFRA and the Environment Agency (including the secretary of state, ministers, under secretaries, and senior officials, chair, ceo) and the organisations listed below: AGC F2 Koura Dupont 3M Chemours Honeywell Solvay National trade associations and groups: Chemical Industries Association, British Coatings Federation, European Fluorocarbons Technical Committee / Cefic Sector Group, Plastics Europe Reduce the timeframe the last 6 months of 2023.

(cass on XW/T) STTI Z0/20E0 AR 286 -- 1172 ENVIRONMENUTNIATLEPDRSOTTAETCETSION AGENCY 1650RAERGCIHONSTlitREET PHILADELPHIA, PA 19103 77 WEST REGION JACKSON V BOULEVARD CHICAGO, IL 60604.

Chemical & Material Risk Management Directorate Office of the Under Secretary of Defense for Acquisition, Technology & Chemical & Material Emergir.^, ...

Victrex materials should only be considered for applications with exposure to these chemicals under exceptional circumstances. 1 Genklene is a registered trademark of ICI 2 Freon is a registered trademark of DuPont 3 Dowtherm is a registered trademark of Dow Chemical 4 Skydrol is a registered trademark of Monsanto 5 Vaseline is a registered trademark of Chesebrough-Pond's, Inc.