m W PHS PKLN 045S EST 411379 VC IF D 3394 90.19.73 HEARING CLERK FOOD AND DRUG ADMINISTRATION ROOM S-9S n.oo REi DEPARTMENT OF HEALTH, EDUCATION AND WELFARE FOOD AND DRUG ADMINISTRATION (91 CFR PARTS 191,19(5,133) PROPOSED RULEMAKING ON ASBESTOS PARTICULES IN FOOD AND DRUGS AS PRINTED IN FEDERAL REGISTER, VOL. 39, NO. 199, FRIDAY, SEPTEMBER 99, 1973 DEAR SIR* THE ABOVE-MENTIONED MEMORANDUM ON "ASBESTOS PARTICLES IN FOOD AND D R U G S " COVERS THE PRINCI9AL PUFSTION OF A POSSIBLE HEALTH RISK THROUGH PARENTERAL DRUGS CONTAINING ASBESTOS PARTICLES.

** NORTH AMERICAN FILTRATION COMPANY 7 INDUSTRIAL AVENUE UPPER SADDLE RIVER, N.

IZ\ Johns-Manville Products Corporation Greenwood Plaza Denver, Colorado 8021 7 (303) 770-1000 July 19, 1974 Hearing Clerk Food & Drug Administration Room 6-86 5600 Fischers Lane Rockville, MD 20852 Dear Sir: On September 28, 1973, the Food & Drug Administration published in the Federal Register a Notice of Proposed Rulemaking relating to asbestos particles in food and drugs (38 F.R. 27076) .

Pergamon Fit Ctiem.

Talc Pneumoconiosis by S.H.

MEMORANDUM OF MEETING March 15, 1976 BETWEEN: SUBJECT: FDA Representatives, Division of Cosmetics Technology; Robert M, Schaffner, Ph.D.

\ \ --s !

DEPARTMENT OF HEALTH, EDUCATION, AN FOOD AND DRUG ADMINISTRATION [21 CFR PARTS 121, 128, 133] ASBESTOS PARTICLES IN FOOD AND DRUGS NOTICE OF PROPOSED RULE MAKING L A ^ 7 0 7 Co The Commissioner of Food and Drugs has received a petition from the Center for Science in the Public Interest, 1779 Church Street, NW., Washington, DC 20036, and the Environmental Defense Fund, 1525 18th Street, NW. , Washington, DC 20036, requesting promulgation of regulations under the Federal Food, Drug, and Cosmetic Act to prohibit the adulteration of food and drugs with asbestos.

SECTION II.B

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J MEMORANDUM OF MEETING March 15, 1976 BETWEEN: SUBJECT: FDA Representatives, Division of Cosmetics Technology; Robert M, Schaffner, Ph.D.

(b) (5) DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE PUBLIC HEALTH SERVICE FOOD AND DRUG ADMINISTRATION W A SH IN G T O N , D.C. 20204 March 19, 1976 Dr.

NDTJMr i S A RU / i - V TO : Ar mand R.

The Cosmetic, Toiletry and Fragrance Association, Inc. 1133 15th STREET, N.W., WASHINGTON, D.C. 20005 * 202/331-1770 TELEX 89-2673 James H.

JOURNAL OF PATHOLOGY, VOL. 158: 7 3 - 8 0 (1 9 8 9 ) SILICA-INDUCED PULMONARY FIBROSIS INVOLVES THE REACTION OF PARTICLES WITH INTERSTITIAL RATHER THAN ALVEOLAR MACROPHAGES D.