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234 GNTER OBERDRSTER TABLE 1 M easured and Norm alized Lung Talc Burden of Rats at the End o f the 4 -Week Inhalation Study o f Talc Exposure concentrations, mg/m3 0 Control 2 (target) 2.3 (actual) 6 (target) 4.3 (actual) 18 (target) ' 17 (actual) Male n tig talc/lung (from NTP report) fig talc/lung per mg/m3exposure concn (% increase over low concn) Female n tig talc/lung fig talc/lung per mg/m3exposure concn (% increase over low concn) 5 4.3 1.6 -- 5 0.58 0.24 -- 5 81.6 2.1 35.5 4 56.5 1.6 24.6 5 186.0 9.3 43.3 (+22%) 5 127.2 9.3 29.6 (+20%) 5 846.0 + 5.5 49.8 (+40%) 5 546.0 35.2 32.1 (+30%) clearance m echanisms, and evidence has been accum u lating th a t these effects are toxicological im plications of a condition of lung "particle overload" (M orrow, 1988).

. 1968 American Industrial Hygiene Association Journal 353 The aluminum and silicas were in all prob ability associated either with the talc mole cule, or additives such as kaolin, or the base material from which the talc was derived. 22 ru .

The Detection of Quartz in Talc by Differential Thermal Analysis Principle Differential thermal analysis (DTA) involves the measurement of thermal reactions which are induced in a sample as it is being heated at a constant rate.

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N ovem ber 27, 1973 HFoeoadrinagndCDlerrukg A d m in istra tio n RR56oo0oc0mk vFi6ilsl-e8h,6e rMs aLryanlaen d 20852 Dear Sir: Enclosed are com m ents pertaining to the FDA publication in the F12e1d.e2r0a0l6R, epgairsategrr,a pVhoci.. 33, P#l1e8a8s,e Sneoptteemthbeeor r2ig8i,n a1l97c3o,pyS eisctitohne only one with photographs suitable for reproduction.

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AMP NO. 1 2 3 4 5 6 7 8 9 10 11 12' 13 14 15 16 17 18 19 20 21 22 TABLE I I I .

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ANALYST WORK SH EET 3.

FILE NAME: Talc (TALC) DATE: 1974 DOC#: TALC501 DOCUMENT DESCRIPTION: NIOSH Memo RE Proposed Regulation on Asbestos Particles in Food and Drugs 5* r r *r \ * \* - + \ r W * - A - V.

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