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GROUP=A LEAD BIOAVAILABILITY IN RATS MR 9660 Group A MODEL 6 Non-Linear Least Squares Summary Statistics Source DF Sum of Squares Regression Residual Uncorrected Total 4 18090.836865 65 3627.303435 69 21718.140300 (Corrected Total) 68 15983.665794 Parameter Estimate Dependent Variable LEAD Mean Square 4522.709216 55.804668 QBS 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 A 492.1053534 B 2.7779115 C 0.2500000 D 0.0039122 GROUP TIME LEAD A 0.5 39.80 A 0.5 68.90 A 0.5 21.10 A 0.5 54.60 A 0.5 49,20 A 1.0 18.60 A 1.0 24.60 A 1.0 68.50 A 1.0 22.80 A 1.0 34.10 A 2.0 15.00 A 2.0 15.10 A 2.0 19, 10 A 2.0 16.60 A 2.0 4.10 A 4.0 10.80 A 4.0 7.80 A 4.0 6.80 A 4.0 2.60 A 4.0 20.30 A 8.0 3.20 A 8.0 4.50 A 8.0 6,50 L95M 40.8239 40.8239 40.8239 40.8239 40.8239 24.5633 24.5633 24.5633 24.5633 24.5633 13.5944 13.5944 13.5944 13,5944 13.5944 5.1184 5.1184 5.1184 5.1184 5.1184 0.8258 0.8258 0.8258 FITTED 47.4675 47.4675 47.4675 47,4675 47.4675 30.5933 30.5933 30.5933 30.5933 30.5933 18.1359 18,1359 18.1359 18.1359 18.1359 9.7333 9.7333 9,7333 9.7333 9.7333 4,6411 4.6411 4.6411 U95K 54,1111 54.1111 54.1111 54.1111 54.1111 36.6233 36.6233 36.6233 36.6233 36.6233 22.6774 22,6774 22.6774 22.6774 22.6774 14.3483 14.3483 14.3483 14.3483 14.3483 8.4564 8.4564 8.4564 SE_FIT 3.32656 3,32656 3.32656 3.32656 3.32656 3.01933 3.01933 3.01933 3.01933 3.01933 2.27399 2.27399 2.27399 2.27399 2.27399 2.31078 2.31078 2.31078 2.31078 2.31078 1.91039 1.91039 1.91039 DUP040002217 LEAD BIOAVAILABILITY IN RATS MR 9660 Group A MODEL 6 OBS GROUP TIME LEAD L95M 24 A 8\ 0 3.60 0.8258 25 A 8.0 0.30 0.8258 26 A 12,0 6.10 -0.9577 27 A 12.0 8.50 -0.9577 28 A 12.0 0.80 -0.9577 29 A 12.0 1.97 -0.9577 30 A 24.0 6.40 -2.7044 31 A 24.0 3,30 -2.7044 32 A 24.0 6.60 -2.7044 33 A 24.0 5.20 -2,7044 34 A 24.0 2,70 -2.7044 35 A 48.0 0.30 -2.4237 36 A 48. 0 1.99 -2.4237 37 A 48.0 6.79 -2.4237 38 A 48.0 4.10 -2.4237 39 A 48.0 0.40 -2.4237 40 A 72.0 2.60 -1.7886 41 A 72.0 1.80 -1.7886 42 A 72.0 3.10 -1.7886 43 A 72.0 1.60 -1.7886 44 A 72.0 0.50 -1.7886 45 A 96.0 2.40 -1.3211 46 A 96.0 1.40 -1.3211 47 A 96.0 0.10 -1.3211 48 A 96.0 1.60 -1.3211 49 A 96.0 1.40 -1.3211 50 A 120.0 2.50 -0.9962 51 A 120.0 1.00 -0.9962 52 A 120.0 2.30 -0.9962 53 A 120.0 0.90 -0.9962 54 A 120 0.70 -0.99624 55 A 144 0,80 -0.76754 56 A 144 1.00 -0.76754 57 A 144 1.60 -0.76754 58 A 144 3.00 -0.76754 59 A 144 0.50 -0.76754 60 A 192 0.20 -0.48131 61 A 192 0.60 -0.48131 62 A 192 0.90 -0.48131 63 A 192 0.60 -0.48131 64 A 192 0.20 -0.48131 65 A 240 0,46 -0.31975 66 A 240 0.36 -0,31975 67 A 240 0.40 -0.31975 68 A 240 0.32 -0.31975 69 A 240 0.54 -0.31975 PITTED U95M SE_FIT 4,6411 4.6411 2.8240 2.8240 2.8240 2.8240 1.0646 1.0646 1.0646 1.0646 1.0646 0.3335 0.3335 0.3335 0.3335 0,3335 0.1531 0.1531 0.1531 0.1531 0.1531 0.0838 0.0838 0.0838 0.0838 0.0838 0.0510 0.0510 0.0510 0.0510 0.050957 0.033212 0.033212 0.033212 0.033212 0.033212 0.016224 0.016224 0.016224 0.016224 0.016224 0.008972 0.008972 0.008972 0.008972 0,008972 8.4564 8.4564 6.6056 6.6056 6.6056 6.6056 4.8336 4.8336 4.8336 4.8336 4.8336 3.0908 3.0908 3.0908 3.0908 3.0908 2.0949 2.0949 2.0949 2.0949 2.0949 1.4888 1.4888 1.4888 1.4888 1.4888 1.0982 1.0982 1.0982 1.0982 1.09815 0.83396 0.83396 0.83396 0.83396 0.83396 0.51376 0.51376 0.51376 0.51376 0.51376 0.33769 0.33769 0,33769 0.33769 0,33769 1.91039 1.91039 1.89355 1.89355 1.89355 1.89355 1.88720 1.88720 1.88720 1.88720 1.88720 1.38059 1.38059 1.38059 1.38059 1.38059 0.97226 0.97226 0.97226 0.97226 0,97226 0.70350 0.70350 0.70350 0.70350 0.70350 0.52435 0.52435 0.52435 0.52435 0.52435 0.40095 0.40095 0.40095 0.40095 0.40095 0.24912 0,24912 0.24912 0.24912 0.24912 0.16460 0.16460 0.16460 0.16460 0.16460 DUP040002218 GROUP=B WE DUP040002219 LEAD BIOAVAILABILITY IN RATS MR 9660 MODEL 6 Non-Linear Least Squares Iterative Phase Dependent Variable LEAD Method: Marquardt Non-Linear Least Squares Summary Statistics Dependent Variable LEAD Source DF Sum of Squares Mean Square Regression Residual Uncorrected Total 4 0.60580910772 66 0.36364089228 70 0.96945000000 0.15145227693 0.00550971049 (Corrected Total) 69 0.61059080000 Parameter Estimate A 0.108691433 B 0.869496880 G 0.500000000 D 1.426014371 OBS GROUP TIME LEAD L95M FITTED U95M SE_FIT 1B 2B 3B 4B 5B 6B 7B 8B 9B 10 B 11 B 12 B 13 B 14 B 15 B 16 B 17 B 18 B 19 B 20 B 0.5 0.5 0.5 0.5 0.5 1.0 1.0 1.0 1.0 1.0 2.0 2.0 2.0 2.0 2.0 4.0 4.0 4.0 4.0 4.0 0.029 0.031 0.024 0.021 0.005 0.023 0.029 0.018 0.022 0.020 0.059 0.057 0.047 0.031 0.053 0.155 0.071 0.071 0.197 0.068 -0.01529 -0.01529 -0.01529 -0.01529 -0.01529 0.00424 0.Q0424 0.00424 0.00424 0.00424 0.04605 0.04605 0.04605 0.04605 0.04605 0.09435 0.09435 0.09435 0.09435 0.09435 0.02187 0.02187 0.02187 0.02187 0.02187 0.04556 0.04556 0.04556 0.04556 0.04556 0.08540 0.08540 0.08540 0.08540 0.08540 0.13788 0.13788 0.13788 0.13788 0.13788 0.05903 0.05903 0.05903 0.05903 0.05903 0.08688 0.08688 0.08688 0.08688 0.08688 0.12474 0.12474 0.12474 0.12474 0.12474 0.18141 0.18141 0.18141 0.18141 0.18141 0.018611 0.018611 0.018611 0.018611 0.018611 0.020697 0.020697 0.020697 0.020697 0.020697 0.019708 0.019708 0.019708 0.019708 0.019708 0.021801 0.021801 0.021801 0.021801 0.021801 DUP040002220 LEAD BIOAVAILABILITY IN RATS MR 9660 Group B MODEL 6 OBS GROUP TIME LEAD L95M FITTED B95M SE_FIT 21 B 8.0 0.290 0.13749 0.18028 0,22307 0.021431 22 B 8.0 0.320 0.13749 0.18028 0.22307 0.021431 23 B 8.0 0.530 0,13749 0.18028 0.22307 0.021431 24 B 8.0 0,250 0.13749 0.18028 0.22307 0.021431 25 B 8.0 0.230 0.13749 0,18028 0,22307 0.021431 26 B 12.0 0.136 0.14218 0.18493 0.22769 0.021413 27 B 12.0 0.113 0.14218 0.18493 0.22769 0.021413 28 B 12.0 0.154 0.14218 0.18493 0.22769 0.021413 29 B 12.0 0.208 0.14218 0.18493 0.22769 0.021413 30 B 12.0 0,113 0.14218 0.18493 0.22769 0.021413 31 B 24.0 0.125 0.09183 0.14271 0,19359 0.025484 32 B 24.0 0.055 0.09183 0.14271 0.19359 0.025484 33 B 24.0 0.059 0.09183 0.14271 0.19359 0.025484 34 B 24.0 0.030 0.09183 0.14271 0.19359 0.025484 35 B 24.0 0.043 0.09183 0.14271 0.19359 0.025484 36 B 48.0 0.059 0.02413 0.06568 0.10724 0.020812 37 B 48.0 0.054 0.02413 0.06568 0.10724 0.020812 38 B 48-0 0.039 0.02413 0.06568 0.10724 0.020812 39 B 48.0 0.041 0.02413 0.06568 0.10724 0.020812 40 B 48.0 0,039 0.02413 0.06568 0.10724 0.020812 41 B 72.0 0.036 -0.00708 0.03024 0.06756 0.018694 42 B 72.0 0.034 -0.00708 0.03024 0.06756 0.018694 43 B 72.0 0.030 -0.00708 0.03024 0.06756 0.018694 44 B 72.0 0.035 -0.00708 0.03024 0.06756 0.018694 45 B 72.0 0.015 -0.00708 0.03024 0.06756 0.018694 46 B 96.0 0,050 -0.01541 0.01456 0.04452 0.015007 47 B 96.0 0.082 -0.01541 0.01456 0.04452 0.015007 48 B 96.0 0.336 -0.01541 0.01456 0.04452 0.015007 49 B 96.0 0.064 -0.01541 0.01456 0.04452 0.015007 50 B 96.0 0.074 -0.01541 0.01456 0.04452 0.015007 51 B 120.0 0.022 -0.01461 0.00732 0.02926 0.010987 52 B 120.0 0,032 -0.01461 0.00732 0.02926 0.010987 53 B 120.0 0.016 -0.01461 0.00732 0.02926 0.010987 54 B 120 0.021 -0.014615 .0073205 0.029256 0.010987 55 B 120 0.017 -0.014615 .0073205 0.029256 0.010987 56 B 144 0.032 -0.011475 .0038251 0.019125 0.007663 57 B 144 0.016 -0.011475 .0038251 0.019125 0,007663 58 B 144 0,030 -0.011475 .0038251 0.019125 0.007663 59 B 144 0.017 -0.011475 .0038251 0,019125 0.007663 60 B 144 0,018 -0.011475 .0038251 0.019125 0.007663 61 B 192 0,011 -0.005868 .0011476 0.008164 0.003514 62 B 192 0.027 -0.005868 .0011476 0.008164 0.003514 63 B 192 0.023 -0,005868 .0011476 0.008164 0.003514 64 B 192 0,016 -0.005868 .0011476 0.008164 0.003514 65 B 192 0.012 -0.005868 .0011476 0.008164 0.003514 66 B 240 0,009 -0.002777 .0003805 0.003538 0,001582 67 B 240 0.000 -0.002777 .0003805 0.003538 0.001582 68 B 240 0.000 -0,002777 .0003805 0.003538 0,001582 69 B 240 0.000 -0.002777 .0003805 0.003538 0,001582 70 B 240 0.018 -0.002777 .0003805 0.003538 0.001582 DUP040002221 LEAD BIOAVAILABILITY IN RATS MR 9660 Group C MODEL 6 Non-Linear Least Squares Summary Statistics Source DF Sum of Squares Regression Residual Uncorrected Total 4 3948.1014775 61 634.6422225 65 4582.7437000 (Corrected Total) 64 2811.0756615 Parameter Estimate Dependent Variable LEAD Mean Square 987.0253694 10.4039709 OBS 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 A 68.66666398 B 1.51226733 C 0.25208104 D 0.00000000 GROUP TIME LEAD C 0,5 15,1 C 0,5 32.5 C 0.5 19,4 C 0.5 11,9 C 0.5 14.2 C 1.0 18.3 c 1.0 17.5 c 1,0 20.7 c 1.0 13.0 c 2.0 7.5 c 2,0 4.3 c 2.0 12.2 c 2.0 9.7 c 2,0 19.1 c 4.0 12.3 c 4.0 6,6 c 4.0 4.4 c 4.0 4.6 c 4-0 7.2 c 8.0 6.3 c 8.0 3.2 c 8.0 0.8 c 8.0 3,9 c 12.0 4.5 L95M 16.4648 16.4648 16.4648 16.4648 16.4648 12.9123 12.9123 12.9123 12,9123 9.3736 9.3736 9.3736 9.3736 9.3736 6.4034 6.4034 6.4034 6.4034 6.4034 3.6262 3.6262 3.6262 3.6262 2.3911 FITTED 19.2871 19.2871 19.2871 19.2871 19.2871 15.1348 15.1348 15.1348 15.1348 11.3392 11.3392 11.3392 11.3392 11,3392 8.0399 8.0399 8.0399 8.0399 8.0399 5.3383 5.3383 5.3383 5.3383 4.0553 U95M 22.1094 22.1094 22.1094 22.1094 22.1094 17.3573 17.3573 17.3573 17.3573 13,3048 13.3048 13.3048 13.3048 13.3048 9.6764 9,6764 9.6764 9.6764 9.6764 7.0505 7.0505 7.0505 7.0505 5.7195 SEJFIT 1,41140 1.41140 1,41140 1.41140 1.41140 1,11146 1.11146 1.11146 1.11146 0.98299 0.98299 0.98299 0.98299 0.98299 0.81839 0.81839 0.81839 0.81839 0.81839 0.85623 0.85623 0.85623 0.85623 0.83225 DUP040002223 GR0UP=C 20 19 18 17 16 15 14 13 12 11 10 9 8 7 6 5 4 3 2 1 0 LEAD BIOAVAILABILITY IN RATS MR 9660 Group C MODEL 6 25 G 12.0 5.4 2,3911 26 C 12.0 5.9 2.3911 27 C 12.0 4.3 2.3911 28 C 12.0 6,9 2.3911 29 G 24.0 0.4 0.9564 30 C 24.0

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