To: BenzConsort-TC@listserve.api.org <BenzConsort-TC@listserve.api.org>; BenzConsort-OC@listserve.api.org <BenzConsort-OC@listserve.api.org> From: Bruce Jarnot <jarnotb@api.org> Cc: Russell White <whiter@api.org>; Howard Feldman <Feldman@api.org>; John Wagner <Wagner@api.org>; Bruce Jarnot <jarnotb@api.org> Bcc: Received Date: 2007-02-1521 :00:20 GMT Subject: BHRC-TC/-OC... 2H06 CC & DP/ME Progress Reports Benzene Health Research Consortium (BHRC) Technical & Oversight Committee members- Attached are pdf copies of Progress Reports for Case Control (CC) and Disease Progression I Molecular Epidemiology (DP/ME) studies for the second half of 2006 (2H06), which I received today from Drs.

DRAFT CINPATHOGEN DELIVERABLES Within five calendar days of the receipt of funds, Cinpathogen will identify progress milestones to be achieved in the second quarter, 2007; 1.

MECHANISTIC INVESTIGATION OF LOW-DOSE METABOLIC INTERACTIONS Issue: Risk Management Department: RASA Program: Risk Management Segment(s): Multi-segment Task Force/Staff: Tox & Benzene TFI Bruce Jarnot Y2008 Budget Amount: $75K Prior Cost: New Future Cost (2009-2013)*: $OK Project Description: Preliminary results from API- and ExxonMobil-funded rodent co-exposures to mixtures of toluene and benzene suggest differences in metabolism I metabolic interaction between these compounds at high doses (e.g., those used in toxicology bioassays) versus interactions observed at low doses (e.g., relevant to current occupational exposures).

This document spells out API's questions with regard to the detailed itemization of how and over what time period the $800,000 advance payment provided to Cinpathogen is to be spent.

Welcoming Remarks 2004 SHS Annual Meeting - Asilomar we can relax and wait for the results to come rolling in, we appreciate that there is much still to be done.

2005 pmt schedule unchange d from current schedule except for BP * 2005 commitme nt paid as of 3/31/05 Benzene Health Research Consortium Budget May 3,2005 Paid through 2004 $16,500, MAP contribution Program Total (J) I m r r sI : () () r C ;a G) Final oI 5/6/05 c..n Page 8 of 19 <D -.....J o o

Benzene Health Research Consortium Budget May 6,2005 UCHSC 2005 - 2007 Increase by Category 2005 2006 2007 TOTALS UCHSC increases EMBSI subcontra ct increases Fudan subcontra ct increases (new) Histology consultant * Cincinnati Children's Hospital** TOTALS (J) I m r r sI : () () r C ;a G) oI c..n <D -.....J o ..j:::o

From: Sent: To: Subject: Stuart, Tsai, Shan SP SHLOIL-SHLOIL-HE Monday, April 14, 2003 10:04 AM Cagen, Stuart Z SCC; Clegg, Patsy M SCC-CHSE-PC; Tholstrup, Susan C SCC; lannarone, Lauren B SCC-CSEA; Owen, David DE SC-CHSE-DO RE: Benzene Shanghai I made some minor changes.

To: Clegg, Patsy M SCC-DCS/22 <patsy.clegg@shell.com> From: Cagen, Stuart Z SHLOIL-SHOIL-SHS </O=SHE LUOU=MSXSCC/CN=RE CI PI ENTS/CN=SC724012> Cc: Bcc: Received Date: 2007-06-22 19:39:49 GMT Subject: FW: REMINDER: Shanghai Health Study conference call - Monday, June 25 at 1 PM EDT Patsy: I have a lunchtime Shell Health - Toxicology meeting on Monday morning and I am bringing the lunch \ Accordingly I might not join the call on Monday or I might be late.

DRAFT CINPATHOGEN CONTRACT MILESTONES This document spells out the expectations of the Study sponsors with regard to the contract for supplemental funding to CinPathogen for completion of the Shanghai Health Study, Consistent with the original scope of work for the Study and grant~ the designj performance and conclusions of the Study are in the sole control of the principal investigators.

To: Benzene OC listserve (E-mail) <BenzConsort-OC@listserve.api.org>; Benzene consort tech (E-mail) <benzconsort-tc@listserve.api.org> From: Lorraine Twerdok <Twerdokl@api.org> Cc: Bcc: Received Date: 2005-08-0818:48:35 GMT Subject: FW: BHRC - August 11 conference call, 2 - 4 PM, EDT To BHRC OC and TC members - > Attached is the draft 2Q05 financial report for your review for the conference call this Thursday, Aug. 11.

Benzene Health Research Consortium 4Q06 Financial Report Overview Fund Balanc e at API 3Q06: Fund Balance in spreadsheet 4Q06: $ 2,532,299 $ 5,030,938 DRAFT Irons Field Expenses: $131,000 disbursed in 4006 UCHSC: $2,298,333 spent in 1st half of 2006 (Actuals per UCHSC official data) AHS: $231,797 spent in 4006 Fudan University: $76,377 paid for 2005 invoice SRP/ERP: $29,771 spent in 4006.

To: From: Cc: Bcc: Received Date: Subject: Tholstrup, Susan C SCC <susan.tholstrup@shell.com> Cagen, Stuart Z SCC <lO=SHELLlOU=MSXSCC/CN=RECI PI ENTS/CN=SC724012> 2003-08-1516:30:14 GMT Tox-Sciences Susan: Some additional and somewhat organized thoughts about a path forward to help facilitate prioritization of Toxicology for growth.

March 5,2007 Via Electronic and U.S.

March 5,2007 Via Electronic and U.S.