Blood First Edition Paper, prepublished online January 25, 2010; DOI 10.1182/blood-2009-10-249722 Genetic variation in the folate metabolic pathway and risk of childhood leukemia Tracy J Lightfoot1*, W Thomas Johnston1, Dan Painter1, Jill Simpson1, Eve Roman1, Chris F Skibola2, Martyn T Smith2, James M Allan3, G Malcolm Taylor4 on behalf of the United Kingdom Childhood Cancer Study 1 Epidemiology & Genetics Unit, Department of Health Sciences, University of York, York, Y010 5DD 2 Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA. 3 Department of Biology, University of York, York, YO10 5DD 4Cancer Immunogenetics Group, School of Cancer and Imaging Sciences, University of Manchester, St Mary's Hospital, Manchester, M13 0JH * Corresponding author Dr Tracy Lightfoot Epidemiology & Genetics Unit Area 3, Seebohm Rowntree Building Department of Health Sciences University of York YO10 5DD United Kingdom Email: tracy.lightfoot@egu.york.ac.uk Tel: +44 (0) 1904 321881 Fax: +44 (0) 1904 321899 1 Copyright 2010 American Society of Hematology Abstract Studies of childhood leukemia and the potential etiological role of genetic variation in folate metabolism have produced conflicting findings and have often been based on small numbers.

HEMATOPOIESIS AND STEM CELLS Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation Tiago C.

Health Effects of Asbestos and IMonasbestos Fibers Omowunmi Y.O, Osinubi, Michael Gochfeld, and Howard M, Kipen UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey, USA Exposures to asbestos and synthetic fibers remain areas of great concern in the field of occupational elsewhere in this monograph.

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D A N A C O R P O R A T IO N / Annual Report 2001 Financial Summary dollars in millions, except per share data Year Ended Sales Income before non-recurring items Net income (loss) Return on sales before non-recurring items Net return on sales Earnings per share before non-recurring items (diluted) Earnings per share (diluted) Average common shares outstanding (diluted) Dividends paid per share Dividend yield Total assets Return on beginning equity Return on average shareholders' equity People at year end Principal facilities Countries 12/31/00 $12,317 $377 $334 3.1% 2.7% $2.46 $2.18 153 million $1.24 8.1% $11,236 11.3% 12.0% 79,288 313 35 12/31/01 $10,271 $5 $(298) 0.0% (2.9)% $0.04 $(2.01) 148 million $0.94 6.8% $10,207 (11.3)% (13.0)% 69,758 300 34 f Sales by Foundation Business-2001 dollars in millions B Axles Brake & Chassis Products B Driveshafts B Fluid Systems fl Bearings & Sealing Products B Structures B Filtration Products Other $ 3,188 1,344 982 831 743 667 573 1,943 Total $ 10,271 1

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